Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP42 OTUD5 SENP2 USP54 OTUD7B	1.38e-05	137	45	5	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP42 OTUD5 SENP2 USP54 OTUD7B	6.98e-05	192	45	5	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	HGFAC USP42 OTUD5 UNC5CL SENP2 USP54 LACTB OTUD7B	9.36e-05	654	45	8	GO:0008233
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP42 OTUD5 USP54 OTUD7B	1.25e-04	114	45	4	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP42 OTUD5 USP54 OTUD7B	1.73e-04	124	45	4	GO:0101005
GeneOntologyMolecularFunction	STAT family protein binding	FAM220BP FAM220A	3.81e-04	13	45	2	GO:0097677
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	OTUD5 OTUD7B	1.01e-03	21	45	2	GO:1990380
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP42 OTUD5 SENP2 USP54 OTUD7B	1.07e-05	144	42	5	GO:0070646
Domain	OTU	OTUD5 OTUD7B	3.44e-04	13	40	2	PF02338
Domain	OTU	OTUD5 OTUD7B	4.61e-04	15	40	2	PS50802
Domain	OTU_dom	OTUD5 OTUD7B	4.61e-04	15	40	2	IPR003323
Domain	Kringle	HGFAC KREMEN2	5.96e-04	17	40	2	IPR000001
Domain	Kringle	HGFAC KREMEN2	5.96e-04	17	40	2	PF00051
Domain	KRINGLE_1	HGFAC KREMEN2	5.96e-04	17	40	2	PS00021
Domain	Kringle_CS	HGFAC KREMEN2	5.96e-04	17	40	2	IPR018056
Domain	KR	HGFAC KREMEN2	5.96e-04	17	40	2	SM00130
Domain	KRINGLE_2	HGFAC KREMEN2	5.96e-04	17	40	2	PS50070
Domain	Kringle-like	HGFAC KREMEN2	2.13e-03	32	40	2	IPR013806
Pubmed	Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	4.19e-21	12	49	8	10433963
Pubmed	Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.09e-20	13	49	8	17668377
Pubmed	The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	5.62e-20	8	49	7	17588759
Pubmed	DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	8.42e-19	10	49	7	17984056
Pubmed	Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.20e-17	13	49	7	7739628
Pubmed	Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.	DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	1.35e-16	17	49	7	11245978
Pubmed	The homeobox transcription factor DUXBL controls exit from totipotency.	DUX4L9 DUX4L2 DUX4L4	1.05e-08	4	49	3	38509386
Pubmed	Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.	DUX4L9 DUX4L2 DUX4L4	1.05e-08	4	49	3	17911620
Pubmed	Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.	DUX4L9 DUX4L2 DUX4L4	2.62e-08	5	49	3	20063414
Pubmed	The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.	DUX4L9 DUX4L2 DUX4L4	9.16e-08	7	49	3	30765463
Pubmed	Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.	DUX4L9 DUX4L2 DUX4L4	1.18e-06	15	49	3	30071041
Pubmed	Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.	DUX4L9 DUX4L2 DUX4L4	1.18e-06	15	49	3	35727972
Pubmed	Association of the human SUMO-1 protease SENP2 with the nuclear pore.	SENP2 NUP153	1.94e-06	2	49	2	11896061
Pubmed	Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.	DUX4L9 DUX4	1.94e-06	2	49	2	24145033
Pubmed	Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2.	SENP2 NUP153	5.83e-06	3	49	2	22688647
Pubmed	SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.	FAM220BP FAM220A	5.83e-06	3	49	2	23917203
Pubmed	Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein.	FAM220BP FAM220A	5.83e-06	3	49	2	19659802
Pubmed	DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.	DUX4L9 DUX4	1.16e-05	4	49	2	19829708
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP42 OTUD5 OTUD7B	1.27e-05	32	49	3	33669244
Pubmed	RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.	DUX4L2 DUX4	1.94e-05	5	49	2	19359275
Pubmed	Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.	FAM220BP FAM220A	1.94e-05	5	49	2	30731284
Pubmed	Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.	FAM220BP FAM220A	1.94e-05	5	49	2	26026268
Pubmed	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.	SENP2 NUP153	4.07e-05	7	49	2	12192048
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	DUX4L9 DUX4L2 DUX4L4	4.92e-05	50	49	3	31806660
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP42 OTUD5 USP54 OTUD7B	5.60e-05	147	49	4	29576527
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZC3H10 DUX4L9 DUX4L2 PLCG1 DUX4L4 DCUN1D3 RXRB	1.31e-04	808	49	7	20412781
Pubmed	USP51 promotes deubiquitination and stabilization of ZEB1.	USP42 USP54	1.50e-04	13	49	2	29119051
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUD5 OTUD7B	3.27e-04	19	49	2	23827681
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SEMA4F FAM220A DUX4 MAP2K5	3.28e-04	233	49	4	37704626
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP42 USP54	4.83e-04	23	49	2	14715245
Cytoband	4q35.2	DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	3.13e-13	27	49	6	4q35.2
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	5.77e-13	117	49	8	chr4q35
Cytoband	7p22.1	USP42 FAM220A	1.17e-03	47	49	2	7p22.1
Cytoband	9q34.11	SPOUT1 LINC02913	1.49e-03	53	49	2	9q34.11
Cytoband	19q13.12	ZNF793 ZNF585B	2.72e-03	72	49	2	19q13.12
GeneFamily	PRD class homeoboxes and pseudogenes	DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7	5.18e-10	92	36	7	521
GeneFamily	OTU domain containing	OTUD5 OTUD7B	5.14e-04	17	36	2	669
GeneFamily	Ubiquitin specific peptidases	USP42 USP54	5.55e-03	56	36	2	366
GeneFamily	EF-hand domain containing	RASGRP4 CRNN PLCG1	9.33e-03	219	36	3	863

Protein segments in the cluster

Peptide	Gene	Start	Entry
RARHPGQGGRAPAQA	DUX4L4	146	P0CJ87
RATDGHRGQCPKGEP	FAM220A	136	Q7Z4H9
HRGQCPKGEPRVSRL	FAM220A	141	Q7Z4H9
ATHGHRGQCPKGEPR	FAM220BP	131	B1ANY3
RARHPGQGGRAPAQA	DUX4L6	146	P0CJ89
RRGAGHREEQVPPCG	DCUN1D3	31	Q8IWE4
HGGRLRFQLPPGGRC	ABCA7	2051	Q8IZY2
RPGHRKPGKNCTNPR	RTN4RL1	346	Q86UN2
PSGGGVHCQEPRRQL	OTUD7B	701	Q6GQQ9
RGPGKGPRPFHCRQI	HRG	441	P04196
RARHPGQGGRAPAQA	DUX4	146	Q9UBX2
SCGRRGVHQRAGLPP	LACTB	21	P83111
RARHPGQGGRAPAQA	DUX4L3	146	P0CJ86
PRACKPPGERNIHGL	MAP2K5	106	Q13163
HQECTGKIGGRGRPR	RASGRP4	11	Q8TDF6
GHQNRTGPRGAGRPC	KREMEN2	46	Q8NCW0
RARNGDHCPLGPGRC	GDF15	196	Q99988
RGQGCGRAQPRHPGT	LCN10	86	Q6JVE6
PASPGRQACGRRHKK	HGFAC	386	Q04756
HPRRCVTEGQGDRQP	CRNN	421	Q9UBG3
QCQRPHGSGRDDKRP	ARHGAP6	866	O43182
RARHPGQGGRAPAQA	DUX4L9	146	Q6RFH8
KRQAQHGRRPGNPRG	GARRE1	861	O15063
LQHRRRLPGAQGPEG	FAM131C	241	Q96AQ9
RARHPGQGGRAPAQA	DUX4L7	146	P0CJ90
KRGCNLRGGRGKHGP	LINC02913	186	Q8NAJ2
RARHPGQGGRAPAQA	DUX4L5	146	P0CJ88
RKRPCGPGEHGQRIE	SPOUT1	6	Q5T280
PGHSKRRRQAPGVGA	OTUD5	146	Q96G74
EGCNRRPGGRRHSKG	SENP2	156	Q9HC62
GPFRELKHDCNRGLP	SEMA4F	356	O95754
GRRPGLKQEDGPHIR	SAMD11	66	Q96NU1
PQRHAAGQCGPVGVR	RXRB	11	P28702
NQPHKCRGDGAPGGR	B3GNT9	101	Q6UX72
VQGLCPHGKPRDKGR	TTLL11	186	Q8NHH1
RPHKDHNRGRRGCEP	USP42	1091	Q9H9J4
INHGRRPNGEKPRGC	ZNF793	176	Q6ZN11
DRRPHHGGVQRVCPQ	SPDYC	186	Q5MJ68
LTNEQPHGGRLRGPC	UNC5CL	281	Q8IV45
ALQGERPRHSCPGEK	ZNF585B	86	Q52M93
GARHLPKNGRGIVCP	PLCG1	1096	P19174
GGGGKIRTRRCHQGP	NUP153	11	P49790
RACKGHQGLQARLGP	THAP3	221	Q8WTV1
EDHEPGPKRRRGGCC	ZC3H10	201	Q96K80
QQVKHCRQSRGPGGP	TRIM65	351	Q6PJ69
RCRLGPHTDNIGRGP	TRIM65	406	Q6PJ69
GRPGRCRKQHDLGNC	TMEM239	11	Q8WW34
VHPGGLQGPRRREAQ	SNAPC2	81	Q13487
HCRGRGGDQPDKKPP	USP54	531	Q70EL1
RARHPGQGGRAPAQA	DUX4L2	146	P0CJ85
GSGQRPPRCHQVFRG	ART1	166	P52961