Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	1.12e-09	431	78	14	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	1.40e-06	884	78	15	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2L2 OR1M1 OR7G1 PTPRC OR2B2 OR1I1 OR1J1 OR8K5 CD74 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 CHRNA2 OR1J2	3.47e-06	1353	78	18	GO:0004888
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	PHKA2 PRKAA1 PRKAB1 LRRK2 SIK1 ATM ULK1 MAP3K7 BCR	5.95e-05	446	78	9	GO:0004674
GeneOntologyMolecularFunction	histone kinase activity	PRKAA1 ATM MAP3K7	1.75e-04	28	78	3	GO:0035173
GeneOntologyMolecularFunction	protein serine kinase activity	PRKAA1 LRRK2 SIK1 ATM ULK1 MAP3K7 BCR	5.41e-04	363	78	7	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	PHKA2 PRKAA1 PRKAB1 LRRK2 SIK1 ATM ULK1 MAP3K7 BCR	5.42e-04	600	78	9	GO:0004672
GeneOntologyMolecularFunction	AMP-activated protein kinase activity	PRKAA1 PRKAB1	6.64e-04	10	78	2	GO:0004679
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2 RYR2 NOD2	6.38e-11	524	76	16	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of smell	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 BBS4 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	1.27e-10	465	76	15	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	5.34e-10	432	76	14	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 BBS4 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	1.19e-09	547	76	15	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	2.38e-09	485	76	14	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2 RYR2 NOD2	6.58e-09	722	76	16	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	2.39e-08	582	76	14	GO:0050906
GeneOntologyBiologicalProcess	sensory perception	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 CLN6 BBS4 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	1.44e-06	1072	76	16	GO:0007600
GeneOntologyBiologicalProcess	positive regulation of dendritic cell antigen processing and presentation	SLC11A1 CD74 NOD2	1.66e-06	7	76	3	GO:0002606
GeneOntologyBiologicalProcess	regulation of dendritic cell antigen processing and presentation	SLC11A1 CD74 NOD2	7.77e-06	11	76	3	GO:0002604
GeneOntologyBiologicalProcess	positive regulation of antigen processing and presentation	SLC11A1 CD74 NOD2	7.77e-06	11	76	3	GO:0002579
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 LRRK2 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	3.97e-05	1395	76	16	GO:0007186
GeneOntologyBiologicalProcess	dendritic cell antigen processing and presentation	SLC11A1 CD74 NOD2	6.10e-05	21	76	3	GO:0002468
GeneOntologyBiologicalProcess	regulation of antigen processing and presentation	SLC11A1 CD74 NOD2	8.07e-05	23	76	3	GO:0002577
GeneOntologyBiologicalProcess	regulation of microglial cell activation	PTPRC LRRK2 ATM	8.07e-05	23	76	3	GO:1903978
GeneOntologyBiologicalProcess	macrophage activation	SLC11A1 PTPRC LRRK2 CD74 ATM	1.68e-04	140	76	5	GO:0042116
GeneOntologyBiologicalProcess	regulation of macrophage activation	PTPRC LRRK2 CD74 ATM	2.28e-04	81	76	4	GO:0043030
GeneOntologyBiologicalProcess	interleukin-2 production	SLC11A1 PTPRC MAP3K7 NOD2	2.39e-04	82	76	4	GO:0032623
GeneOntologyBiologicalProcess	positive regulation of adaptive immune response	SLC11A1 PTPRC CD74 MAP3K7 NOD2	3.04e-04	159	76	5	GO:0002821
GeneOntologyBiologicalProcess	vacuole organization	ATG9B FIG4 LRRK2 CLN6 ATM ULK1	3.15e-04	249	76	6	GO:0007033
GeneOntologyBiologicalProcess	regulation of B cell activation	PTPRC CD74 ATM PCID2 NOD2	3.41e-04	163	76	5	GO:0050864
GeneOntologyBiologicalProcess	regulation of intracellular pH	RAB38 SLC11A1 LRRK2 CLN6	4.04e-04	94	76	4	GO:0051453
GeneOntologyCellularComponent	trans-Golgi network	RAB38 ATG9B LRRK2 SMPD4 CD74 ECPAS LGR5	1.46e-04	306	78	7	GO:0005802
GeneOntologyCellularComponent	nuclear envelope	IPO5 ATP1B4 PARP8 UGT2B4 PHLPP1 SMPD4 PCID2 RYR2 NUP205	2.35e-04	560	78	9	GO:0005635
GeneOntologyCellularComponent	protein kinase complex	PHKA2 PRKAA1 PRKAB1 ULK1 CCNA2	4.38e-04	170	78	5	GO:1902911
Domain	Olfact_rcpt	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	6.68e-10	393	77	14	IPR000725
Domain	7tm_1	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	9.19e-08	677	77	15	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	1.07e-07	685	77	15	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	1.20e-07	691	77	15	PS50262
Domain	GPCR_Rhodpsn	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	1.22e-07	692	77	15	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J2 OR2T10 LGR5 OR7G2 OR10R2 OR1J2	5.30e-07	670	77	14	IPR017452
Domain	ARM-type_fold	IPO5 NBEAL1 MROH2A LRRK2 EFR3B DAAM2 ATM ECPAS	7.68e-05	339	77	8	IPR016024
Domain	6hp_glycosidase	PHKA2 LANCL3	4.62e-04	8	77	2	IPR012341
Domain	-	PHKA2 LANCL3	4.62e-04	8	77	2	1.50.10.10
Domain	ARM-like	IPO5 MROH2A LRRK2 EFR3B DAAM2 ECPAS	8.68e-04	270	77	6	IPR011989
Domain	6-hairpin_glycosidase-like	PHKA2 LANCL3	1.27e-03	13	77	2	IPR008928
Domain	-	IPO5 LRRK2 EFR3B DAAM2 ECPAS	2.24e-03	222	77	5	1.25.10.10
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	PRKAA1 SIK1 ULK1	2.90e-03	69	77	3	IPR020636
Domain	HEAT_REPEAT	IPO5 MROH2A ECPAS	3.02e-03	70	77	3	PS50077
Domain	Rho_GTPase_activation_prot	RASA3 SYDE2 BCR	5.75e-03	88	77	3	IPR008936
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	2.52e-09	417	62	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	1.07e-08	389	62	13	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	4.90e-07	636	62	14	M41834
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	ATRIP PRKAA1 PRKAB1 ATM CCNA2	5.12e-05	92	62	5	MM15338
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	ATRIP PRKAA1 PRKAB1 ATM CCNA2	5.12e-05	92	62	5	M27636
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR7G1 OR2J1 OR2J2 OR7G2	2.50e-04	70	62	4	MM14984
Pathway	REACTOME_MACROAUTOPHAGY	ATG9B PRKAA1 PRKAB1 ATM ULK1	2.62e-04	130	62	5	MM14627
Pathway	WP_AUTOPHAGY	PRKAA1 PRKAB1 ULK1	3.02e-04	30	62	3	M39904
Pubmed	The human olfactory receptor gene family.	OR2L2 OR1M1 OR7G1 OR2B2 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR2T10 OR7G2 OR10R2 OR1J2	2.37e-10	541	78	13	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR7G2	2.88e-10	340	78	11	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR7G2	2.88e-10	340	78	11	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR7G2	3.16e-10	343	78	11	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2L2 OR1M1 OR7G1 OR2B2 OR1I1 OR1J1 OR8K5 OR6Y1 OR2J1 OR2J2 OR7G2	3.46e-10	346	78	11	14611657
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR7G1 OR2B2 OR1I1 OR8K5 OR6Y1 OR7G2	1.72e-08	74	78	6	15081110
Pubmed	Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process.	PRKAA1 PRKAB1 MAP3K7	1.08e-07	5	78	3	20538596
Pubmed	The association of AMPK with ULK1 regulates autophagy.	PRKAA1 PRKAB1 ULK1	1.08e-07	5	78	3	21072212
Pubmed	Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.	PRKAA1 PRKAB1 ULK1	3.77e-07	7	78	3	21460634
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR1M1 OR7G1 OR1I1 OR1J1 OR7G2 OR10R2 OR1J2	6.45e-07	219	78	7	12213199
Pubmed	Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.	IPO5 ATRIP ATM	1.77e-06	11	78	3	15758953
Pubmed	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.	PRKAA1 PRKAB1 ULK1	3.05e-06	13	78	3	28561066
Pubmed	IRGM governs the core autophagy machinery to conduct antimicrobial defense.	PRKAA1 ULK1 NOD2	3.05e-06	13	78	3	25891078
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	PRKAA1 PRKAB1 ULK1	4.84e-06	15	78	3	25686248
Pubmed	Regulation of erythrocyte survival by AMP-activated protein kinase.	PRKAA1 PRKAB1	4.97e-06	2	78	2	19050047
Pubmed	Enhanced technique to measure proteins in single segments of human skeletal muscle fibers: fiber-type dependence of AMPK-alpha1 and -beta1.	PRKAA1 PRKAB1	4.97e-06	2	78	2	21088205
Pubmed	AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression.	PRKAA1 CCNA2	4.97e-06	2	78	2	24012615
Pubmed	Restriction of intracellular Salmonella typhimurium growth by the small-molecule autophagy inducer A77 1726 through the activation of the AMPK-ULK1 axis.	PRKAA1 ULK1	4.97e-06	2	78	2	33461007
Pubmed	Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.	PRKAA1 ATM	4.97e-06	2	78	2	29284117
Pubmed	Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species.	PRKAA1 ATM	4.97e-06	2	78	2	22260947
Pubmed	Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes.	RAB38 LRRK2	4.97e-06	2	78	2	37625589
Pubmed	Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response.	PRKAA1 ATM	4.97e-06	2	78	2	38166485
Pubmed	Allele-dependent interaction of LRRK2 and NOD2 in leprosy.	LRRK2 NOD2	4.97e-06	2	78	2	36972292
Pubmed	Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.	PRKAA1 PRKAB1	4.97e-06	2	78	2	16405649
Pubmed	Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965.	PRKAA1 ULK1	4.97e-06	2	78	2	34259310
Pubmed	Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy.	PRKAA1 ULK1	4.97e-06	2	78	2	36240643
Pubmed	Is TAK1 a Direct Upstream Kinase of AMPK?	PRKAA1 MAP3K7	4.97e-06	2	78	2	30111748
Pubmed	Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.	PRKAA1 ULK1	4.97e-06	2	78	2	21205641
Pubmed	Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.	MAP3K7 NOD2	4.97e-06	2	78	2	15075345
Pubmed	AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.	PRKAA1 ULK1	4.97e-06	2	78	2	27864418
Pubmed	ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.	LRRK2 ULK1	4.97e-06	2	78	2	27023913
Pubmed	A Systemic Review and Meta-analysis on Natural Resistance-associated Macrophage Protein 1 (3'-Untranslated Region) and Nucleotide-binding Oligomerization Domain-2 (rs8057341) Polymorphisms and Leprosy Susceptibility in Asian and Caucasian Populations.	SLC11A1 NOD2	4.97e-06	2	78	2	38916380
Pubmed	Role of AMP-activated protein kinase α1 in angiotensin-II-induced renal Tgfß-activated kinase 1 activation.	PRKAA1 MAP3K7	4.97e-06	2	78	2	27230958
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PHKA2 CTTNBP2 PRKAA1 PRKAB1 CLN6 BCR CCNA2 DHX30	5.83e-06	432	78	8	23455922
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PHKA2 MYH8 PRKAA1 PRKAB1 SIK1 ULK1 ADNP MAP3K7 BCR PTER CCNA2	5.83e-06	910	78	11	36736316
Pubmed	Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.	ATRIP ATM	1.49e-05	3	78	2	18344416
Pubmed	AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1.	PRKAA1 PRKAB1	1.49e-05	3	78	2	23785098
Pubmed	Genomic Characterization of Metformin Hepatic Response.	PRKAA1 ATM	1.49e-05	3	78	2	27902686
Pubmed	Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.	PRKAA1 ULK1	1.49e-05	3	78	2	24955726
Pubmed	TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.	PRKAA1 MAP3K7	1.49e-05	3	78	2	19197243
Pubmed	AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.	PRKAA1 PRKAB1	1.49e-05	3	78	2	19211918
Pubmed	Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.	PRKAA1 PRKAB1	1.49e-05	3	78	2	30478170
Pubmed	MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma.	PRKAA1 ULK1	1.49e-05	3	78	2	28791376
Pubmed	AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.	PRKAA1 MAP3K7	1.49e-05	3	78	2	20696287
Pubmed	Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells.	LRRK2 NOD2	1.49e-05	3	78	2	28330897
Pubmed	The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.	LGR5 NOD2	1.49e-05	3	78	2	24882705
Pubmed	AMP-activated protein kinase positively regulates FGF-2-stimulated VEGF synthesis in osteoblasts.	PRKAA1 PRKAB1	1.49e-05	3	78	2	20708602
Pubmed	SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.	PRKAA1 ULK1	1.49e-05	3	78	2	39107544
Pubmed	Tumor resistance to radiotherapy is triggered by an ATM/TAK1-dependent-increased expression of the cellular prion protein.	ATM MAP3K7	1.49e-05	3	78	2	33767435
Pubmed	Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.	PRKAA1 PRKAB1	1.49e-05	3	78	2	38266576
Pubmed	LRRK2 and RIPK2 variants in the NOD 2-mediated signaling pathway are associated with susceptibility to Mycobacterium leprae in Indian populations.	LRRK2 NOD2	1.49e-05	3	78	2	24015287
Pubmed	DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia.	PRKAA1 MAP3K7	1.49e-05	3	78	2	32224048
Pubmed	Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.	MAP3K7 NOD2	1.49e-05	3	78	2	17348859
Pubmed	Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.	PRKAA1 PRKAB1	1.49e-05	3	78	2	20421294
Pubmed	Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α.	PRKAA1 ULK1	1.49e-05	3	78	2	27687210
Pubmed	Red Pepper Seed Inhibits Differentiation of 3T3-L1 Cells during the Early Phase of Adipogenesis via the Activation of AMPK.	PRKAA1 PRKAB1	1.49e-05	3	78	2	29316805
Pubmed	AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines.	PRKAA1 ATM	1.49e-05	3	78	2	34973534
Pubmed	Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression.	PRKAA1 PRKAB1	1.49e-05	3	78	2	10760274
Pubmed	Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits.	PRKAA1 PRKAB1	1.49e-05	3	78	2	8663446
Pubmed	The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.	PRKAA1 PRKAB1	1.49e-05	3	78	2	21892142
Pubmed	Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.	PRKAA1 PRKAB1	1.49e-05	3	78	2	27411013
Pubmed	The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice.	PRKAA1 PRKAB1	1.49e-05	3	78	2	22253816
Pubmed	Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.	PRKAA1 PRKAB1	1.49e-05	3	78	2	23515442
Pubmed	AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway.	PRKAA1 MAP3K7	1.49e-05	3	78	2	20615388
Pubmed	Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.	PRKAA1 PRKAB1	1.49e-05	3	78	2	30232152
Pubmed	TAK1 is a central mediator of NOD2 signaling in epidermal cells.	MAP3K7 NOD2	1.49e-05	3	78	2	17965022
Pubmed	Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway.	PRKAA1 ULK1	1.49e-05	3	78	2	30053525
Pubmed	Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling.	PRKAA1 ULK1	1.49e-05	3	78	2	33531625
Pubmed	Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.	PRKAA1 ULK1	1.49e-05	3	78	2	26103054
Pubmed	Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells.	PRKAA1 MAP3K7	1.49e-05	3	78	2	24072697
Pubmed	Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.	PRKAA1 ULK1	1.49e-05	3	78	2	34107300
Pubmed	Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs.	PRKAA1 PRKAB1	1.49e-05	3	78	2	14985344
Pubmed	Production and Crystallization of Full-Length Human AMP-Activated Protein Kinase (α1β1γ1).	PRKAA1 PRKAB1	1.49e-05	3	78	2	29480465
Pubmed	Role of AMP-activated protein kinase in autophagy and proteasome function.	PRKAA1 PRKAB1	1.49e-05	3	78	2	18328803
Pubmed	Comprehensive analysis of differential gene expression profiles on D-galactosamine-induced acute mouse liver injury and regeneration.	ATM CCNA2	2.97e-05	4	78	2	16962228
Pubmed	Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.	PRKAA1 ULK1	2.97e-05	4	78	2	25980607
Pubmed	IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.	PRKAB1 ATM	2.97e-05	4	78	2	21573174
Pubmed	LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.	LRRK2 NOD2	2.97e-05	4	78	2	27830463
Pubmed	LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.	RAB38 LRRK2	2.97e-05	4	78	2	31552791
Pubmed	LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.	LRRK2 ATM	2.97e-05	4	78	2	28973420
Pubmed	Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.	PRKAA1 PRKAB1	2.97e-05	4	78	2	27941154
Pubmed	Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.	PRKAA1 PRKAB1	2.97e-05	4	78	2	17525164
Pubmed	Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.	MAP3K7 NOD2	2.97e-05	4	78	2	22520462
Pubmed	BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK.	PRKAA1 ULK1	2.97e-05	4	78	2	23291726
Pubmed	Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.	LGR5 NOD2	2.97e-05	4	78	2	31919280
Pubmed	Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.	PRKAA1 ULK1	2.97e-05	4	78	2	28639909
Pubmed	Functional modulation of AMP-activated protein kinase by cereblon.	PRKAA1 PRKAB1	2.97e-05	4	78	2	21232561
Pubmed	Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4CRBN Protein Degradation Axis.	PRKAA1 PRKAB1	2.97e-05	4	78	2	34073624
Pubmed	Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.	PRKAA1 LRRK2	2.97e-05	4	78	2	22012985
Pubmed	AMP kinase promotes glioblastoma bioenergetics and tumour growth.	PRKAA1 PRKAB1	2.97e-05	4	78	2	29915361
Pubmed	V600EBRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells.	PRKAA1 ULK1	2.97e-05	4	78	2	34204950
Pubmed	CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.	ATRIP ATM	2.97e-05	4	78	2	20048340
Pubmed	Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.	PRKAA1 PRKAB1	2.97e-05	4	78	2	21873433
Pubmed	Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.	PRKAA1 MAP3K7	2.97e-05	4	78	2	17855357
Pubmed	AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.	PRKAA1 ULK1	2.97e-05	4	78	2	22932492
Pubmed	Commensal bacteria direct selective cargo sorting to promote symbiosis.	LRRK2 NOD2	2.97e-05	4	78	2	26237551
Pubmed	IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.	PRKAA1 ATM	2.97e-05	4	78	2	15485651
Pubmed	AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.	PRKAA1 PRKAB1	2.97e-05	4	78	2	18390901
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	PRKAA1 PRKAB1 SIK1	4.22e-05	30	78	3	16306228
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	ATRIP FIG4 NBEAL1 CLN6 SMPD4 ULK1	4.50e-05	285	78	6	34369648
GeneFamily	Olfactory receptors, family 1	OR1M1 OR1I1 OR1J1 OR1J2	7.45e-06	40	57	4	147
GeneFamily	Olfactory receptors, family 2	OR2L2 OR2B2 OR2J1 OR2J2 OR2T10	2.82e-05	113	57	5	149
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE MYH8 CTTNBP2 ABCA12 MROH2A RYR2	3.83e-07	160	78	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE MYH8 CTTNBP2 ABCA12 MROH2A RYR2	3.83e-07	160	78	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC11A1 PTPRC RASA3 SIK1 ZNF710	1.06e-05	165	78	5	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC11A1 PTPRC RASA3 SIK1 ZNF710	1.06e-05	165	78	5	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE STAB2 ABCA12 MROH2A RYR2	1.80e-05	184	78	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE STAB2 ABCA12 MROH2A RYR2	1.80e-05	184	78	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE STAB2 ABCA12 MROH2A RYR2	1.80e-05	184	78	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	SLC11A1 PTPRC PARP8 DAAM2 ZNF710	2.15e-05	191	78	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A1 PTPRC LRRK2 ZNF710 NOD2	2.15e-05	191	78	5	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	SLC11A1 PTPRC PARP8 DAAM2 ZNF710	2.20e-05	192	78	5	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	SLC11A1 PTPRC PARP8 DAAM2 ZNF710	2.20e-05	192	78	5	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	CTRL-Myeloid-Alveolar_Macrophage\|Myeloid / Disease state, Lineage and Cell class	TRHDE SLC11A1 FIG4 CD74 SAMD4A	2.26e-05	193	78	5	80871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	SLC11A1 PTPRC PARP8 DAAM2 ZNF710	2.26e-05	193	78	5	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A1 PTPRC CD74 ZNF710 NOD2	2.49e-05	197	78	5	8af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A1 PTPRC PARP8 CD74 ZNF710	2.49e-05	197	78	5	c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A1 PTPRC CD74 ZNF710 NOD2	2.49e-05	197	78	5	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A1 PTPRC CD74 ZNF710 NOD2	2.55e-05	198	78	5	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC11A1 PTPRC PARP8 CD74 ZNF710	2.61e-05	199	78	5	155b03b859157013e9142e9248551369127d9204
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE SEMA3C SLC11A1 FIG4 CD74	2.68e-05	200	78	5	a443e475e7a10c26a6173d1af961de6219e0e567
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRHDE SEMA3C SLC11A1 FIG4 CD74	2.68e-05	200	78	5	ed785a6d08ca2b350dc3307b587eadfb2886d1f9
Computational	Neighborhood of CASP8	PTPRC PARP8 ATM	1.04e-04	27	37	3	GNF2_CASP8
Drug	ICI 182,780; Up 200; 1uM; PC3; HT_HG-U133A	SLC11A1 OR2B2 TCP11L1 CD74 LGR5 CHRNA2 SAMD4A	4.33e-06	192	78	7	4429_UP
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	STAB2 OR2B2 CD74 ECPAS CYP39A1 TIGD6 NOD2	5.48e-06	199	78	7	4990_UP
Disease	Crohn's disease (is_implicated_in)	SLC11A1 LRRK2 NOD2	5.85e-05	30	74	3	DOID:8778 (is_implicated_in)
Disease	leprosy (is_implicated_in)	SLC11A1 NOD2	1.72e-04	8	74	2	DOID:1024 (is_implicated_in)
Disease	Crohn Disease	SLC11A1 LRRK2 NOD2	2.73e-04	50	74	3	C0010346
Disease	cesarean section, intelligence	C6orf89 TAF1A	4.03e-04	12	74	2	EFO_0004337, EFO_0009636
Disease	unipolar depression, alcohol dependence	TRHDE BBS4 MAP3K7	1.01e-03	78	74	3	EFO_0003761, MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSGHLKPLHYNLMLT	TRHDE	141	Q9UKU6
YETIHLTEEPTKLMH	ADNP	936	Q9H2P0
RHDLTYIMLGKIHLL	BBS4	166	Q96RK4
ETYLSHLEALLLPMK	BCR	511	P11274
LHFPKTYLKDQHLSM	ABCA12	2506	Q86UK0
LLSPHMQKALEGVHY	CHRNA2	461	Q15822
ALGMHESKYLILPVH	DHX30	691	Q7L2E3
KLTHVNYTSPLVAMH	ATP1B4	301	Q9UN42
LPEEKTQMYHALLKH	AOX1	326	Q06278
TQMYHALLKHLGTLA	AOX1	331	Q06278
DIHLHTPMYFLLSQL	OR2L2	51	Q8NH16
KIYELLFMNLHLPSL	NBEAL1	1646	Q6ZS30
MQAPHKEHLYKLLVI	RAB38	1	P57729
LAGMHYLHVTLKPAI	RASA3	386	Q14644
SLMLYHEHLRKDLPS	NUP205	561	Q92621
LSLEVKLHLLHSYMN	OTUD7B	416	Q6GQQ9
LLSVLHHCLQMPYKR	DAAM2	376	Q86T65
LLHYLIMILEKHFPD	DAAM2	841	Q86T65
IILTKLDSHLHTPMY	OR8K5	46	Q8NH50
MLLIQLDSHLHTPMY	OR1J2	46	Q8NGS2
IIILSYLDSHLHTPM	OR2J1	46	Q9GZK6
LKFMHTPHQFLLLSS	PARP8	661	Q8N3A8
SLMHLLIPTLFHMKY	ECPAS	136	Q5VYK3
MTHLHEPGVLYNLKE	MYH8	96	P13535
KIIMYSIQPQHSHLV	EFR3B	276	Q9Y2G0
LLLDQHMLKVHYPKF	CES5A	101	Q6NT32
VAYLHSMQPKALIHR	MAP3K7	141	O43318
ILQMLLSYHEHLKPS	LANCL3	241	Q6ZV70
HSAMIIYRDLKPHNV	LRRK2	1986	Q5S007
IIMPHNIYLHSALVK	SLC11A1	251	P49279
ILAIITDSHLHTPMY	OR1I1	46	O60431
MLLIQLDSHLHTPMY	OR1J1	46	Q8NGS3
IIILSYVDSHLHTPM	OR2J2	46	O76002
YLDNLVKHLHSIMVL	IPO5	481	O00410
ISHLHLLVVKEYEMP	GREB1L	1541	Q9C091
MQSPHAKLEVLHYRL	SMPD4	321	Q9NXE4
HGYSHILTNVVPKML	PTER	311	Q96BW5
ILLIHIDSSLHTPMY	OR2T10	46	Q8NGZ9
NLPAHLVVIKSTMHY	HFM1	621	A2PYH4
LLAVISDSHLHTPMY	OR7G1	46	Q8NGA0
LLGHMPTVELLKKYH	PCID2	261	Q5JVF3
KIPMVLHLFDTLHAL	EXOC5	646	O00471
LEPTKSLHLHMYLML	ATM	936	Q13315
SLHLHMYLMLLKELP	ATM	941	Q13315
VDSLKLLMYHRIPAH	CTTNBP2	856	Q8WZ74
PTDFYLHHKNTMRLL	FIG4	611	Q92562
PQLLLQTALAHMHYL	ATG9B	586	Q674R7
LAYVLSHPDIHKAIM	CYP39A1	286	Q9NYL5
HVMHLLQNADPLKVY	CD74	141	P04233
HPLLKMLLHLLAFSS	ATRIP	536	Q8WXE1
LMDLHQTYLKAPQHA	CCNA2	391	P20248
IHHIRLMSLPIAKKY	C6orf89	101	Q6UWU4
EHAKMPLKLLTNHYE	RYR2	2601	Q92736
IATSKRYHLQPMHLL	MFSD5	301	Q6N075
LAENLKVLYPHHMAQ	CDH16	246	O75309
LSPFDMKNLLHHILS	PHKA2	946	P46019
MTLALNKIHHIPDYA	LGR5	191	O75473
ILVSHVDFKLHTPMY	OR2B2	46	Q9GZK3
ILAISIDSHLHTPMY	OR1M1	46	Q8NGA1
ICHPLHYAKIMSLRL	OR1M1	126	Q8NGA1
ISVIHLDKSLHTPMY	OR10R2	66	Q8NGX6
VMYELQHHLKPLNLT	MROH2A	161	A6NES4
MLLDHLKLVASYHEV	SYDE2	956	Q5VT97
KILLTDMHLPSFHLK	TCP11L1	376	Q9NUJ3
LGIIHTMKVLYQSHL	TIGD6	316	Q17RP2
SLSHHPLDYRILLMD	SEMA3C	46	Q99985
YQIVPSHKLMLEFHT	TAF1A	301	Q15573
LLAVISDSHLHTPMY	OR7G2	46	Q8NG99
QLMKLLNHPHIIKLY	SIK1B	76	A0A0B4J2F2
LNHPHIIKLYQVMET	SIK1B	81	A0A0B4J2F2
QLMKLLNHPHIIKLY	SIK1	76	P57059
LNHPHIIKLYQVMET	SIK1	81	P57059
ILAIHSDGQLHKPMY	OR6Y1	51	Q8NGX8
QYLNPSVISLLKHML	PRKAA1	246	Q13131
PNHVMLNHLYALSIK	PRKAB1	231	Q9Y478
HMAYNVITPFLLLKL	CLN6	86	Q9NWW5
TDMYLLILQHFLLHA	NOD2	511	Q9HC29
PLYKENAMKLSRIHH	UGT2B4	436	P06133
LKRHMLLHSEVKPYS	ZNF710	366	Q8N1W2
LSQSNIPALIKYHML	STAB2	1051	Q8WWQ8
LLSMHLRVHTGEKPY	ZNF74	346	Q16587
LLTGHPHLKILHMAY	PHLPP1	1031	O60346
PHLKILHMAYNRLQS	PHLPP1	1036	O60346
NLSELHPYLHNMKKR	PTPRC	921	P08575
YMKLLPKILAHSIEH	SAMD4A	101	Q9UPU9
RYHKALLLLEGLQHM	ULK1	1006	O75385