Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	GDS_CDC24_CS	MCF2 ARHGEF3 ARHGEF6	1.36e-04	39	48	3	IPR001331
Domain	DH_1	MCF2 ARHGEF3 ARHGEF6	5.68e-04	63	48	3	PS00741
Domain	RhoGEF	MCF2 ARHGEF3 ARHGEF6	7.10e-04	68	48	3	SM00325
Domain	RhoGEF	MCF2 ARHGEF3 ARHGEF6	7.73e-04	70	48	3	PF00621
Domain	DH_2	MCF2 ARHGEF3 ARHGEF6	7.73e-04	70	48	3	PS50010
Domain	DH-domain	MCF2 ARHGEF3 ARHGEF6	8.05e-04	71	48	3	IPR000219
Domain	-	MCF2 ARHGEF3 ARHGEF6	8.05e-04	71	48	3	1.20.900.10
Domain	SPRY	MID2 TRIM34 RYR2	1.45e-03	87	48	3	SM00449
Domain	SPRY	MID2 TRIM34 RYR2	1.81e-03	94	48	3	PF00622
Domain	SPRY_dom	MID2 TRIM34 RYR2	1.81e-03	94	48	3	IPR003877
Domain	B30.2/SPRY	MID2 TRIM34 RYR2	1.87e-03	95	48	3	IPR001870
Domain	B302_SPRY	MID2 TRIM34 RYR2	1.87e-03	95	48	3	PS50188
Domain	Spectrin_repeat	MCF2 MACF1	2.51e-03	29	48	2	IPR002017
Domain	Spectrin/alpha-actinin	MCF2 MACF1	3.05e-03	32	48	2	IPR018159
Domain	SPEC	MCF2 MACF1	3.05e-03	32	48	2	SM00150
Domain	Q_MOTIF	DDX50 DDX18	4.07e-03	37	48	2	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX50 DDX18	4.07e-03	37	48	2	IPR014014
Domain	EFh	SLC25A24 MACF1 RYR2	7.78e-03	158	48	3	SM00054
Pathway	PID_CDC42_REG_PATHWAY	RALBP1 MCF2 ARHGEF6	5.92e-05	30	36	3	M83
Pathway	PID_RAC1_REG_PATHWAY	RALBP1 MCF2 ARHGEF6	1.21e-04	38	36	3	M241
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	MCF2 ARHGEF3 ARHGEF6	3.10e-04	52	36	3	MM14743
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	MCF2 ARHGEF3 ARHGEF6	4.51e-04	59	36	3	M11215
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	MCF2 ARHGEF3 ARHGEF6	7.44e-04	70	36	3	MM14824
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	MCF2 ARHGEF3 ARHGEF6	9.46e-04	76	36	3	M19832
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	MCF2 ARHGEF3 ARHGEF6	9.83e-04	77	36	3	MM15044
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	MCF2 ARHGEF3 ARHGEF6	1.10e-03	80	36	3	M800
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	NELFB MLLT3 TAF1L	1.14e-03	81	36	3	M865
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	NELFB MLLT3 TAF1L	1.22e-03	83	36	3	MM15314
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	MCF2 ARHGEF3 ARHGEF6	1.31e-03	85	36	3	MM14746
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	RALBP1 POLK ARHGEF6	1.49e-03	89	36	3	M39732
Pathway	REACTOME_CDC42_GTPASE_CYCLE	RALBP1 MCF2 ARHGEF6	1.75e-03	94	36	3	MM15598
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	MCF2 ARHGEF3 ARHGEF6	1.91e-03	97	36	3	M9400
Pathway	KEGG_MEDICUS_VARIANT_MLL_AF4_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	AFF1 MLLT3	1.98e-03	26	36	2	M47439
Pubmed	Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.	AFF1 MLLT3	1.94e-06	2	49	2	8506309
Pubmed	MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.	AFF1 MLLT3	1.94e-06	2	49	2	28114278
Pubmed	MLL fusion partners AF4 and AF9 interact at subnuclear foci.	AFF1 MLLT3	1.94e-06	2	49	2	14603337
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NPHP3 DDX50 SYT1 AFF1 MACF1 ATP11A ARHGEF3 POLK MGA ARHGEF6	2.26e-06	1084	49	10	11544199
Pubmed	Lost in transcription: molecular mechanisms that control HIV latency.	NELFB AFF1 MLLT3	2.51e-06	19	49	3	23518577
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SLC25A24 DNAJB1 DDX50 RALBP1 AHNAK MCF2 ARHGEF3 MGA ARHGEF6	4.68e-06	916	49	9	32203420
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NPHP3 NELFB ZNF286B MACF1 ATP11A MGA DENND3	5.66e-06	493	49	7	15368895
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	IFRD1 DDX50 SLF2 AHNAK DDX18 ANKRD11 SYT1 MGA TAF1L	6.50e-06	954	49	9	36373674
Pubmed	Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.	AFF1 MLLT3	1.16e-05	4	49	2	25282333
Pubmed	Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.	AFF1 MLLT3	1.16e-05	4	49	2	17581865
Pubmed	Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.	AFF1 MLLT3	1.94e-05	5	49	2	23260655
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	MCF2 ARHGEF3 ARHGEF6	2.14e-05	38	49	3	11756498
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DNAJB1 IFRD1 SLF2 AHNAK NELFB ZNF286B ANKRD11 MACF1	2.51e-05	861	49	8	36931259
Pubmed	Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.	AFF1 MLLT3	2.91e-05	6	49	2	21896721
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	MCF2 ARHGEF3 ARHGEF6	3.12e-05	43	49	3	12376548
Pubmed	Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.	AFF1 MLLT3	5.42e-05	8	49	2	32479599
Pubmed	Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions.	AFF1 MLLT3	6.96e-05	9	49	2	36036574
Pubmed	Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.	AFF1 MLLT3	6.96e-05	9	49	2	24565118
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	MCF2 ARHGEF3 ARHGEF6	8.50e-05	60	49	3	12787561
Pubmed	A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.	AFF1 MLLT3	8.69e-05	10	49	2	20153263
Pubmed	Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.	AFF1 MLLT3	8.69e-05	10	49	2	19000783
Pubmed	[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia].	AFF1 MLLT3	8.69e-05	10	49	2	16215946
Pubmed	HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.	AFF1 MLLT3	1.06e-04	11	49	2	20471949
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	DNAJB1 DDX50 AHNAK DDX18 LTV1 MGA	1.16e-04	547	49	6	37267103
Pubmed	The little elongation complex regulates small nuclear RNA transcription.	AFF1 MLLT3	1.27e-04	12	49	2	22195968
Pubmed	Transcriptional and posttranscriptional regulation of HIV-1 gene expression.	AFF1 MLLT3	1.50e-04	13	49	2	22355797
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	SLF2 NELFB SYT1 RYR2	1.54e-04	191	49	4	20195357
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	MACF1 BCKDHA MGA	1.72e-04	76	49	3	27542412
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	AFF1 MLLT3	1.75e-04	14	49	2	20854876
Pubmed	Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel.	DNAJB1 TRIM34	2.02e-04	15	49	2	25472883
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PTPDC1 IFRD1 MID2 LPCAT3 ANKRD11 AFF1 MACF1 ATP11A POLK	2.06e-04	1489	49	9	28611215
Pubmed	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.	ANKRD11 AFF1	2.30e-04	16	49	2	10932191
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	SLF2 DDX18 POLK MGA	2.73e-04	222	49	4	37071664
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF3 ARHGEF6	2.93e-04	18	49	2	12799088
Pubmed	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	AFF1 MLLT3	2.93e-04	18	49	2	21030982
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	MID2 TRIM34	2.93e-04	18	49	2	23077300
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DDX50 AHNAK MACF1 LTV1	3.34e-04	234	49	4	36243803
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	DDX50 AHNAK DDX18 LTV1	3.97e-04	245	49	4	35652658
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	DDX50 AHNAK DDX18 DNAH2	3.97e-04	245	49	4	21182205
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	DDX50 SLF2 AHNAK POLK MGA	3.98e-04	444	49	5	34795231
Pubmed	The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.	AFF1 MLLT3	4.41e-04	22	49	2	22567366
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DNAJB1 PTPDC1 NPHP3 LPCAT3 AHNAK BCKDHA LTV1 ARHGEF6	4.78e-04	1321	49	8	27173435
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	DNAJB1 MID2 AHNAK DDX18 MACF1 MGA	5.21e-04	724	49	6	36232890
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	AHNAK DDX18 ANKRD11 TAF1L	5.64e-04	269	49	4	29511261
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DNAJB1 DDX50 MGA TAF1L	6.82e-04	283	49	4	30585729
Pubmed	The protein kinase complement of the human genome.	STK32A STK32B	7.18e-04	28	49	2	12471243
Pubmed	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.	DDX18 MLLT3	7.18e-04	28	49	2	20689807
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DDX50 AHNAK DDX18 NELFB MGA RYR2	7.53e-04	777	49	6	35844135
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SLC25A24 NWD2 DDX50 DDX18 USP12 MACF1 ARHGEF6	7.60e-04	1082	49	7	38697112
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	DDX50 ZNF789 AHNAK DNAH2 HKDC1 MACF1 ATP11A RYR2	8.49e-04	1442	49	8	35575683
Pubmed	Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).	DDX50 DDX18	8.81e-04	31	49	2	26678539
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	RALBP1 ANKRD11 USP12 BCKDHA ATP11A	9.31e-04	536	49	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	RALBP1 ANKRD11 USP12 BCKDHA ATP11A	9.46e-04	538	49	5	10512203
Pubmed	DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.	AFF1 MLLT3	1.06e-03	34	49	2	32152128
Pubmed	Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.	IFRD1 PRSS23	1.06e-03	34	49	2	12878157
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	AFF1 PRSS23 RYR2	1.07e-03	142	49	3	11812828
Pubmed	Defining the membrane proteome of NK cells.	DDX50 PLXNC1 LPCAT3 AHNAK DDX18 CHSY1 ATP11A	1.19e-03	1168	49	7	19946888
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	ARHGEF3 ARHGEF6	1.32e-03	38	49	2	19911011
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF1 MLLT3	1.15e-04	9	33	2	1280
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	MCF2 ARHGEF3 ARHGEF6	2.34e-04	66	33	3	722
GeneFamily	DEAD-box helicases	DDX50 DDX18	2.66e-03	42	33	2	499
GeneFamily	X-linked mental retardation\|Angiotensin receptors	MID2 ARHGEF6	4.20e-03	53	33	2	103
GeneFamily	EF-hand domain containing	SLC25A24 MACF1 RYR2	7.32e-03	219	33	3	863
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	MID2 TRIM34	1.30e-02	95	33	2	59
Coexpression	GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_DN	CROT SLF2 AFF1 ATE1 ARHGEF6	3.32e-05	197	49	5	M8271
Coexpression	GSE8515_CTRL_VS_IL1_4H_STIM_MAC_UP	CROT RALBP1 MLLT3 ARHGEF3 ARHGEF6	3.49e-05	199	49	5	M5759
Coexpression	GSE10239_KLRG1INT_VS_KLRG1HIGH_EFF_CD8_TCELL_DN	SLC25A24 CROT PLXNC1 ARHGEF3 ARHGEF6	3.49e-05	199	49	5	M3070
Coexpression	GSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_DN	IFRD1 LPCAT3 AHNAK DDX18 ATP11A	3.57e-05	200	49	5	M9628
Coexpression	GSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4HIGH_BCELL_DN	PLXNC1 USP12 MLLT3 TRIM34 ARHGEF3	3.57e-05	200	49	5	M9839
Coexpression	GSE40273_GATA1_KO_VS_WT_TREG_DN	PLXNC1 ANKRD11 CHSY1 ATE1 MGA	3.57e-05	200	49	5	M9133
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d8.LisOva, CD8+ CD45.1+, Spleen, avg-3	SLC25A24 CROT AHNAK CHSY1 MACF1 MLLT3 ARHGEF3	2.50e-05	380	49	7	GSM605901_500
ToppCell	COVID-19-kidney-CNT\|kidney / Disease (COVID-19 only), tissue and cell type	KCNC4 RALBP1 CHSY1 MLLT3 ARHGEF3	2.20e-06	192	49	5	d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJB1 MID2 AHNAK HKDC1	3.17e-05	164	49	4	8f3255d7f67890389a768453492243ea982eb38a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINB10 CFAP221 HKDC1 FAM47E	4.27e-05	177	49	4	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	SLF2 AHNAK MACF1 PRSS23	4.27e-05	177	49	4	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINB10 CFAP221 HKDC1 FAM47E	4.37e-05	178	49	4	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINB10 CFAP221 HKDC1 FAM47E	4.37e-05	178	49	4	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNC1 AHNAK MACF1 DENND3	4.56e-05	180	49	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNC1 AHNAK MACF1 DENND3	4.56e-05	180	49	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLF2 AHNAK ANKRD11 MACF1	4.97e-05	184	49	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NWD2 ARHGEF3 DENND3 RYR2	5.18e-05	186	49	4	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	(02)_Cycling_Basal_(regeneration)-(1)_24hpi\|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint	IFRD1 SERPINB10 AHNAK LTV1	5.51e-05	189	49	4	311f3aed469be3c8ff913dcc5a2442daa8446d55
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KCNC4 CFAP221 STK32B HKDC1	5.74e-05	191	49	4	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP221 HKDC1 ARHGEF3 PRSS23	5.74e-05	191	49	4	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP221 HKDC1 ARHGEF3 PRSS23	5.74e-05	191	49	4	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNC4 CFAP221 HKDC1 ATP11A	6.22e-05	195	49	4	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNC4 CFAP221 HKDC1 ATP11A	6.22e-05	195	49	4	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	DNAJB1 AHNAK MACF1 PRSS23	6.35e-05	196	49	4	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	severe-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DNAJB1 AHNAK MACF1 PRSS23	6.35e-05	196	49	4	d83acd9abd7b296989b8ae09da63799e6877a149
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	AHNAK MACF1 ARHGEF3 PRSS23	6.47e-05	197	49	4	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	AHNAK MACF1 ARHGEF3 PRSS23	6.60e-05	198	49	4	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	control-Lymphocytic-NK_cells\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	AHNAK MACF1 ARHGEF3 PRSS23	6.60e-05	198	49	4	1c779101d0c5f29de5cc7170d784931d6e34bdcd
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	AHNAK MACF1 ARHGEF3 PRSS23	6.60e-05	198	49	4	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IFRD1 PLXNC1 ATP11A DENND3	6.73e-05	199	49	4	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	AHNAK MACF1 ARHGEF3 PRSS23	6.86e-05	200	49	4	2281debd86e5d92e8fe0397aec9ef670800f7471
Disease	twisted gastrulation protein homolog 1 measurement	RALBP1 ARHGEF3	6.91e-05	8	47	2	EFO_0803205
Disease	susceptibility to mononucleosis measurement	DNAH2 USP12 RYR2	1.84e-04	69	47	3	EFO_0008403
Disease	free cholesterol to total lipids in large LDL percentage	AFF1 MACF1 POLK	2.27e-04	74	47	3	EFO_0022280
Disease	Prostatic Neoplasms	SERPINB10 RNASEL RALBP1 POLK MGA TAF1L	4.19e-04	616	47	6	C0033578
Disease	Malignant neoplasm of prostate	SERPINB10 RNASEL RALBP1 POLK MGA TAF1L	4.19e-04	616	47	6	C0376358
Disease	facial hair thickness measurement	AFF1 MACF1	1.19e-03	32	47	2	EFO_0007823
Disease	Mental Retardation, X-Linked 1	MID2 ARHGEF6	1.19e-03	32	47	2	C2931498
Disease	skin pigmentation measurement	ANKRD11 MLLT3 ATP11A	1.37e-03	137	47	3	EFO_0007009
Disease	Liver Cirrhosis, Experimental	SLC25A24 IFRD1 CROT RNASEL AHNAK CHSY1	1.37e-03	774	47	6	C0023893
Disease	Borderline personality disorder	SYT1 CCDC168	1.43e-03	35	47	2	HP_0012076
Disease	forced expiratory volume	PTPDC1 AHNAK AFF1 PRSS23 ATE1 RYR2	1.51e-03	789	47	6	EFO_0004314

Protein segments in the cluster

Peptide	Gene	Start	Entry
LKLAKKAYHDPMLKL	ARHGEF3	141	Q9NR81
KSPKTMKKFLHKRKT	ARHGEF6	621	Q15052
MKKFLHKRKTERKPS	ARHGEF6	626	Q15052
RDHFKKEEKLSKMKL	ANKRD11	691	Q6UB99
PHKLMKEHKEKPSKD	MLLT3	196	P42568
KLKGPKFKMPDLHLK	AHNAK	4111	Q09666
KFKMPDLHLKAPKIS	AHNAK	4116	Q09666
DHVKKFKLPKKHMQL	DENND3	636	A2RUS2
KKMKISHKRLNPDGK	DNAJB1	181	P25685
FKAAVKLLHEKGKMK	NWD2	211	Q9ULI1
SKMKRSKGIHVFKKP	RALBP1	101	Q15311
MPHRKKKPFIEKKKA	LTV1	1	Q96GA3
KDSSFHKLKMKDLKD	MGA	2771	Q8IWI9
KHKFKVKEMYLTKLL	PLXNC1	1341	O60486
VMKHLPKVPEKKLKL	NELFB	116	Q8WX92
YIHKAMVPRKEKLKK	LPCAT3	471	Q6P1A2
LKKIFKHTLEEKRKM	PTPDC1	731	A2A3K4
MSHLPMKLLRKKIEK	DDX18	1	Q9NVP1
VHPLDKKEMLKKTFL	MACF1	2226	Q9UPN3
KKEMLKKTFLAKDDH	MACF1	2231	Q9UPN3
LDAPKAKKSKMKEKL	DDX50	56	Q9BQ39
KKKLEMHFHKLPSLL	IFRD1	261	O00458
HKKGATKMKDLARFK	MCF2	706	P10911
PSKSHKKVLKKMLKF	ATE1	86	O95260
KDIMHPEDKGLKAKK	CCDC168	4166	Q8NDH2
LLDSKQMLKKHKEKF	DNAH2	1131	Q9P225
KTHFLPLMEKLKKKA	RYR2	3316	Q92736
KKLTKNKMLHPDTFI	CROT	406	Q9UKG9
HLPKEKVLKLYKSMT	BCKDHA	96	P12694
HLGKDPMSFKLKKEL	CFAP221	381	Q4G0U5
SKLKEKFMNELHKIP	SYT1	41	P21579
RKGMKEPTKLLKKHS	FAM47E	166	Q6ZV65
KPKMVSKKLKTVFHA	TRIM34	266	Q9BYJ4
DFMKTKDLKHKKLPL	HKDC1	136	Q2TB90
KHLAILYKKMGKLDK	NPHP3	1181	Q7Z494
QPLLKHIKKKAKMRE	TAF1L	656	Q8IZX4
ELKKPHKRKFMKIGV	PRSS23	251	O95084
EKHKKMKLKIGDPSL	RNASEL	676	Q05823
HLPKEMKSLKKKHRS	SLF2	156	Q8IX21
MILESKPLHKKKKRL	STK32A	316	Q8WU08
DLKVPAKAKLTKLKM	AFF1	326	P51825
LLLLYKKHKGKKMTV	CHSY1	451	Q86X52
YAIPKFKHLKKMLLV	ATP11A	856	P98196
DKDKFVKPLEMSHKK	POLK	551	Q9UBT6
MKVKKLPMILALHLK	USP12	246	O75317
MKPSKLKRHLYSKHK	ZBED9	771	Q6R2W3
EEMILESKPLHKKKK	STK32B	316	Q9NY57
LMKKQRTYKEKKPHK	ZNF286B	231	P0CG31
FKLDPKMTHKKLKIS	MID2	536	Q9UJV3
DHEKKMKLAFKSLDK	SLC25A24	86	Q6NUK1
FMKKKLHIFHIEKPK	SERPINB10	221	P48595
EARHKMKKLTPKQKF	ZNF789	91	Q5FWF6
LAMAKQKLPKKRKKH	KCNC4	481	Q03721