Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	AAA+_ATPase	MMAA SPG7 SRP54 DNAH6 DNAH9	2.20e-04	144	71	5	IPR003593
Domain	AAA	MMAA SPG7 SRP54 DNAH6 DNAH9	2.20e-04	144	71	5	SM00382
Domain	Cl-channel_core	CLCN4 CLCN5	5.04e-04	9	71	2	IPR014743
Domain	-	CLCN4 CLCN5	5.04e-04	9	71	2	1.10.3080.10
Domain	Voltage_CLC	CLCN4 CLCN5	5.04e-04	9	71	2	PF00654
Domain	Cl-channel_volt-gated	CLCN4 CLCN5	5.04e-04	9	71	2	IPR001807
Domain	Acyl-CoA_dh_1	ACADS ACOX3	1.08e-03	13	71	2	PF00441
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH9	1.26e-03	14	71	2	IPR024317
Domain	Dynein_HC_stalk	DNAH6 DNAH9	1.26e-03	14	71	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH6 DNAH9	1.26e-03	14	71	2	IPR013602
Domain	DHC_N2	DNAH6 DNAH9	1.26e-03	14	71	2	PF08393
Domain	MT	DNAH6 DNAH9	1.26e-03	14	71	2	PF12777
Domain	AAA_8	DNAH6 DNAH9	1.26e-03	14	71	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH6 DNAH9	1.26e-03	14	71	2	IPR011704
Domain	AAA_5	DNAH6 DNAH9	1.26e-03	14	71	2	PF07728
Domain	DHC_fam	DNAH6 DNAH9	1.45e-03	15	71	2	IPR026983
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACADS ACOX3	1.45e-03	15	71	2	IPR006091
Domain	Acyl-CoA_dh_M	ACADS ACOX3	1.45e-03	15	71	2	PF02770
Domain	AcylCoA_DH/oxidase_NM_dom	ACADS ACOX3	1.45e-03	15	71	2	IPR009100
Domain	Dynein_heavy_dom	DNAH6 DNAH9	1.45e-03	15	71	2	IPR004273
Domain	Dynein_heavy	DNAH6 DNAH9	1.45e-03	15	71	2	PF03028
Domain	CBS	CLCN4 CLCN5	1.65e-03	16	71	2	SM00116
Domain	AcylCo_DH/oxidase_C	ACADS ACOX3	1.65e-03	16	71	2	IPR009075
Domain	CBS_dom	CLCN4 CLCN5	2.59e-03	20	71	2	IPR000644
Domain	CBS	CLCN4 CLCN5	2.59e-03	20	71	2	PF00571
Domain	CBS	CLCN4 CLCN5	2.59e-03	20	71	2	PS51371
Domain	AMP_BINDING	ACSS1 DIP2C	5.05e-03	28	71	2	PS00455
Domain	AMP-binding	ACSS1 DIP2C	5.79e-03	30	71	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSS1 DIP2C	5.79e-03	30	71	2	IPR000873
Pubmed	Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain.	DOCK2 SIAE	4.23e-06	2	72	2	27210752
Pubmed	Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.	CLCN4 CLCN5	4.23e-06	2	72	2	16129671
Pubmed	Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.	CLCN4 CLCN5	4.23e-06	2	72	2	16034421
Pubmed	Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus.	CLCN4 CLCN5	1.27e-05	3	72	2	9256467
Pubmed	B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.	DOCK2 SIAE	1.27e-05	3	72	2	19103880
Pubmed	A contravention of Ohno's law in mice.	CLCN4 CLCN5	2.53e-05	4	72	2	7670497
Pubmed	Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.	CLCN4 CLCN5	2.53e-05	4	72	2	7670496
Pubmed	Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.	CLCN4 CLCN5	2.53e-05	4	72	2	20351103
Pubmed	Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.	CLCN4 CLCN5	2.53e-05	4	72	2	19546591
Pubmed	Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.	DNAH6 DNAH9	2.53e-05	4	72	2	11175280
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	CLCN4 CLCN5	4.21e-05	5	72	2	19339555
Pubmed	An atlas of genetic influences on human blood metabolites.	SLC5A11 SLC6A12 ACADS UGT1A6 DIP2C	4.80e-05	190	72	5	24816252
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RIOK1 NOA1 MTR MPDZ PFAS HNRNPF LRRC41 GNPAT	5.96e-05	650	72	8	38777146
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ASXL1 CORO2B ATG4B DIP2C	6.15e-05	102	72	4	10231032
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN4 CLCN5	6.31e-05	6	72	2	10198195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK2 ACSS1 DIP2C PFAS UBN2 NPHP4 TMEM200A	7.33e-05	493	72	7	15368895
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	KIAA1671 AFTPH MPDZ SRP54 PFAS	7.54e-05	209	72	5	36779422
Pubmed	Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9.	FOXB1 CYP19A1	8.82e-05	7	72	2	19640321
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN4 CLCN5	1.51e-04	9	72	2	23115349
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NAA35 AFTPH DPP9 MTR UBA6 MPDZ SRP54 PFAS RCC1 COA7 LRRC41	2.31e-04	1487	72	11	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KIAA1671 URI1 DPP9 TM9SF4 UBA6 DIP2C SRP54 COG3 UBN2 HNRNPF LRRC41	2.34e-04	1489	72	11	28611215
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	DOCK2 NAA35 AHNAK RCC1 COG3 TMEM200A HNRNPF GSN	2.62e-04	807	72	8	30575818
Pubmed	Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.	DNAH6 DNAH9	3.25e-04	13	72	2	35942101
Pubmed	Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.	AHNAK HNRNPF GSN	3.39e-04	65	72	3	34645483
Pubmed	Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.	NEMP1 CUX2	3.78e-04	14	72	2	9179496
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPG7 SPEG AHNAK ZMIZ2 DIP2C PFAS BCL9 NPHP4 ACOX3	4.51e-04	1105	72	9	35748872
Pubmed	p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration.	CUX2 GSN	6.33e-04	18	72	2	23022035
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	KIAA1671 RIOK1 AFTPH SMCHD1 AHNAK SRP54 PFAS HNRNPF	6.89e-04	934	72	8	33916271
Pubmed	Biochemistry of mammalian peroxisomes revisited.	ACOX3 GNPAT	7.84e-04	20	72	2	16756494
Pubmed	Interaction network of human early embryonic transcription factors.	KIAA1671 NEMP1 ZMIZ2 BCL9 UBN2	8.19e-04	351	72	5	38297188
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TM9SF4 SMCHD1 AHNAK HNRNPF	8.35e-04	202	72	4	33005030
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	ASXL1 CLCN4 BCL9	8.78e-04	90	72	3	15033168
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	URI1 RIOK1 NOA1 AHNAK COA7 HNRNPF	9.56e-04	547	72	6	37267103
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KIAA1671 SMCHD1 AHNAK MPDZ RCC1 UBN2	9.75e-04	549	72	6	38280479
Pubmed	Proteome analysis of the circadian clock protein PERIOD2.	SMCHD1 AHNAK GSN	9.96e-04	94	72	3	35122331
Pubmed	MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.	MTX1 COA7	1.04e-03	23	72	2	22114354
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	SIAE UGT1A6	1.13e-03	24	72	2	24625756
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	PFAS MTX1 COA7	1.16e-03	99	72	3	31723608
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	SPG7 ACADS ACSS1 MTX1 COA7	1.19e-03	382	72	5	29222160
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	NEMP1 ASXL1 CUX2 DIP2C	1.24e-03	225	72	4	12168954
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK2 RIOK1 SMCHD1 AHNAK SRP54 HNRNPF	1.31e-03	582	72	6	20467437
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	SMCHD1 AHNAK HNRNPF	1.41e-03	106	72	3	19394292
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	MTR MPDZ	1.43e-03	27	72	2	33417976
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	KIAA1671 URI1 RIOK1 FAM117A AHNAK NPHP4 COA7 GAB2 GSN	1.59e-03	1321	72	9	27173435
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	KIAA1671 DPP9 SPG7 MTR PFAS LRRC41	1.61e-03	606	72	6	36538041
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	UGT1A6 UBA6 SRP54 PFAS RCC1 GSN	1.63e-03	607	72	6	39147351
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	DOCK2 URI1 RIOK1 MTR ETNPPL	1.79e-03	419	72	5	33001583
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC6A12 SLC43A1	1.89e-03	31	72	2	18195088
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DOCK2 SMCHD1 ZMIZ2 SRP54 RCC1 BCL9 UBN2 GSN	1.98e-03	1103	72	8	34189442
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	KIAA1671 CUX2 AFTPH ZMIZ2 BCL9	2.00e-03	430	72	5	35044719
GeneFamily	Chloride voltage-gated channels	CLCN4 CLCN5	2.23e-04	10	41	2	302
GeneFamily	Dyneins, axonemal	DNAH6 DNAH9	6.68e-04	17	41	2	536
GeneFamily	Solute carriers	SLC5A11 SLC6A12 SLC43A1 SLC38A11	1.20e-02	395	41	4	752
ToppCell	Transverse-(2)_B_cell-(23)_Follicular_B_cell\|Transverse / shred on region, Cell_type, and subtype	CORO2B CLCN4 C12orf42 SLC38A11 CHI3L2 PXK	8.51e-07	199	72	6	9c49e114e17cdefc2651050fc3251e59ea251289
ToppCell	Transverse-B_cell-Follicular_B_cell\|Transverse / Region, Cell class and subclass	CORO2B CLCN4 C12orf42 SLC38A11 CHI3L2 PXK	8.51e-07	199	72	6	1fa6e464fc929e721738e175389b85018c5e975f
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CORO2B CLCN4 C12orf42 SLC38A11 CHI3L2	1.31e-05	187	72	5	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CORO2B CLCN4 C12orf42 SLC38A11 CHI3L2	1.42e-05	190	72	5	112706d64ee73b55dcf76f33ca064ab1fc6ce87f
Drug	daunorubicin HCl; Down 200; 1uM; MCF7; HT_HG-U133A	ASXL1 SMCHD1 DIP2C MPDZ PFAS RCC1 BCL9	2.43e-06	191	72	7	7507_DN
Drug	perfluorooctanoic acid	SIAE CYP19A1 PFAS ACOX3	1.75e-05	49	72	4	CID000009554
Drug	perfluorododecanoic acid	CYP19A1 PFAS ACOX3	3.33e-05	20	72	3	CID000067545
Drug	AC1L1ESQ	DOCK2 SPG7 CYP19A1 DNAH9 HNRNPF	3.50e-05	117	72	5	CID000002931
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	SPG7 HIKESHI ZMIZ2 SLC43A1 RCC1 BCL9	3.57e-05	195	72	6	6338_DN
Drug	nocodazole; Up 200; 1uM; MCF7; HG-U133A	ASXL1 URI1 HIKESHI MTR DIP2C GAB2	3.57e-05	195	72	6	621_UP
Drug	Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; PC3; HT_HG-U133A	ASXL1 HIKESHI TM9SF4 MTR RCC1 BCL9	3.78e-05	197	72	6	6296_DN
Drug	Chloroquine diphosphate [50-63-5]; Down 200; 7.8uM; PC3; HT_HG-U133A	NEMP1 CLCN4 SPG7 MPDZ RCC1 GAB2	3.89e-05	198	72	6	7251_DN
Drug	Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; PC3; HT_HG-U133A	NAA35 HIKESHI SPEG DIP2C MPDZ RCC1	4.00e-05	199	72	6	7254_DN
Disease	Dent disease (implicated_via_orthology)	CLCN4 CLCN5	1.71e-05	3	71	2	DOID:0050699 (implicated_via_orthology)
Disease	Hypopituitarism	LHX4 CYP19A1	5.68e-05	5	71	2	C0020635
Disease	BMI-adjusted waist-hip ratio, forced expiratory volume	CUX2 CYP19A1	8.51e-05	6	71	2	EFO_0004314, EFO_0007788
Disease	osteopetrosis (implicated_via_orthology)	CLCN4 CLCN5	1.19e-04	7	71	2	DOID:13533 (implicated_via_orthology)
Disease	Alcohol withdrawal syndrome	CYP19A1 MPDZ	1.58e-04	8	71	2	C0236663

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAEILPAMAMRPFFG	ACSS1	461	Q9NUB1
LLPMPGVMVGDIGKK	ACOX3	236	O15254
DSILGEPGMGFKIAM	ACADS	251	P16219
PMYAAGLGMLEPTKE	AFTPH	751	Q6ULP2
FCPVNLMKPLFPGMG	FAM117A	381	Q9C073
FSMPKIGIPGVKMEG	AHNAK	5236	Q09666
GMPSEKVVMGIPTYG	CHI3L2	256	Q15782
GMKIPSGLFIPSMAV	CLCN4	461	P51793
SGERLMMPPAAFKGE	CUX2	486	O14529
MMPPAAFKGEAGGLL	CUX2	491	O14529
GEDFVPDIVTMGKPM	ETNPPL	266	Q8TBG4
VGHLEGMPFVMDLPF	ASXL1	1396	Q8IXJ9
CFMMPQSLGVIGGKP	ATG4B	246	Q9Y4P1
GVIGLLEPMKKSMVP	RCC1	151	P18754
GMCKGMPSPEIQLGF	ANKRD31	56	Q8N7Z5
PQALGMEVTMVPGKG	UROD	91	P06132
MPAFPGMDPAVLKAQ	KIAA1671	1721	Q9BY89
PLFMAMVGPLKGEPF	SLC43A1	496	O75387
MQFPMGPACIFLRKG	CABP5	1	Q9NP86
MAGGMKVAVSPAVGP	NEMP1	1	O14524
GAVKGLPEMLGVPMQ	LHX4	11	Q969G2
MVDMFVLLLPPAGGD	MMAA	256	Q8IVH4
PGMVGPAVIVDKKMQ	PRR13	96	Q9NZ81
MVVSGDMLGFGRVKP	NPHP4	796	O75161
KMPGGLAFSAMQPVP	FOXB1	181	Q99853
LVTEMFMGEPLFPGD	CDKL2	191	Q92772
LPSPEDGVLVHGMFM	DNAH6	4051	Q9C0G6
VVVFMLGTIPFPEGM	HIKESHI	36	Q53FT3
MEFRSPAPQKGLGVM	CORO2B	311	Q9UQ03
KICFIPGMVGPILEM	DOCK2	1081	Q92608
VFTNQMPLGPMGFLK	CYP3A43	101	Q9HB55
PVPVIAAGMDFLGMK	GNPAT	181	O15228
PFFMKALSGPGLVRM	CYP19A1	146	P11511
GKNGFMVSPMKPLEI	DPP9	166	Q86TI2
PAPGDLAYPDKLVMM	COG3	481	Q96JB2
ELEFGMVPSGMKGDV	BCL9	706	O00512
FGMKIPSGLFIPSMA	CLCN5	516	P51795
LVMPGAIMCSVKPDG	DIP2C	706	Q9Y2E4
AEDLAPMLKVMAGPG	FAAH2	276	Q6GMR7
EPAHLMSLFGGKPMI	GSN	531	P06396
DMPIFMGLIGDLFPA	DNAH9	2086	Q9NYC9
EVKPAPMMEAKGGLD	ETV3L	311	Q6ZN32
PMMEAKGGLDPREVF	ETV3L	316	Q6ZN32
LPIGAVVMVFGFVMA	SLC38A11	346	Q08AI6
LLQIPMGGKERMAGF	NOA1	586	Q8NC60
MGGKERMAGFPPLVA	NOA1	591	Q8NC60
VFPGQRVGKMAAPME	MTX1	141	Q13505
MMLGPEGGEGFVVKL	HNRNPF	1	P52597
MSDGVGSFLPGKMIV	GAB2	426	Q9UQC2
VMSFIGKDDMPAPLL	RIOK1	276	Q9BRS2
IMVPFGPFAFMPGKL	URI1	76	O94763
PPMDKLRGMVFGAPV	SMCHD1	1881	A6NHR9
KMGPFSQILGMIPGF	SRP54	341	P61011
KMLGPFTMGIGIFIF	TMEM200A	126	Q86VY9
RPAQFLPEMVAAMKG	LRRC41	686	Q15345
PLMNGMKIVGDLFGA	MTR	711	Q99707
GLAFIAFPKAVTMMP	SLC6A12	361	P48065
LDPMKPGGPFEVMAQ	SIAE	86	Q9HAT2
KVLPLFIMVFPGMVS	SLC5A11	316	Q8WWX8
MVKQFGMAPGIGPIS	SPG7	661	Q9UQ90
NPVGKGAVAMAPEML	C12orf42	271	Q96LP6
MFLQGAPGFPKDMDL	COA7	156	Q96BR5
VVQGVKMLYVPVMPG	UBA6	986	A0AVT1
NFKRGSFPGVMPMIQ	SIRPB2	86	Q5JXA9
VTPFGMLGGLVPVTM	UBN2	1251	Q6ZU65
VGILMAGILPFGAMF	TM9SF4	501	Q92544
VGSPLGDVPIFIAMM	MPDZ	1881	O75970
GDVPIFIAMMHPTGV	MPDZ	1886	O75970
KGDHPIMMGFEPLVN	NAA35	291	Q5VZE5
EFMAPEMVKGEPIGS	SPEG	3126	Q15772
VPPMGVDGVSAYLMK	SPIN4	6	Q56A73
IKPIMFSGGIGSMEA	PFAS	421	O15067
MAFMEKPPAGKVLLD	PXK	1	Q7Z7A4
VMEMIAALGPGAAPF	ZMIZ2	716	Q8NF64
MLTPMVAGGVVFPGL	TLCD3B	1	Q71RH2
PVMPNMVFIGGINCK	UGT1A6	266	P19224
ICNGVPMVMMPLFGD	UGT1A6	381	P19224