Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF765 SP100 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 GMEB2 RREB1 ZNF467

1.78e-0414125112GO:0000981
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

TIAM1 FRMD7 MCF2 RIC8A FARP2

3.02e-04231515GO:0005085
GeneOntologyCellularComponentextrinsic component of postsynaptic density membrane

TIAM1 CNKSR2

2.59e-0410512GO:0099147
GeneOntologyCellularComponentextrinsic component of postsynaptic specialization membrane

TIAM1 CNKSR2

3.79e-0412512GO:0098892
Domain-

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

1.12e-0667949113.30.160.60
Domainzf-C2H2

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

1.36e-066934911PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

1.38e-066944911IPR013087
Domainzf-C2H2_6

ZNF765 ZNF600 ZNF425 ZNF805 PLAGL2 ZNF468 RREB1 ZNF467

1.45e-06314498PF13912
DomainZINC_FINGER_C2H2_2

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

4.02e-067754911PS50157
DomainZINC_FINGER_C2H2_1

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

4.12e-067774911PS00028
DomainZnf_C2H2-like

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

5.19e-067964911IPR015880
DomainZnf_C2H2

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

5.78e-068054911IPR007087
DomainZnF_C2H2

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

5.99e-068084911SM00355
DomainGDS_CDC24_CS

TIAM1 MCF2 FARP2

1.45e-0439493IPR001331
DomainSAND

SP100 GMEB2

1.87e-048492PF01342
DomainSAND_dom

SP100 GMEB2

1.87e-048492IPR000770
DomainSAND

SP100 GMEB2

1.87e-048492PS50864
DomainSAND

SP100 GMEB2

1.87e-048492SM00258
DomainSAND_dom-like

SP100 GMEB2

4.38e-0412492IPR010919
Domain-

SP100 GMEB2

4.38e-04124923.10.390.10
DomainFA

FRMD7 FARP2

5.16e-0413492SM01195
DomainFERM-adjacent

FRMD7 FARP2

5.16e-0413492IPR014847
DomainFA

FRMD7 FARP2

5.16e-0413492PF08736
DomainDH_1

TIAM1 MCF2 FARP2

6.03e-0463493PS00741
DomainRhoGEF

TIAM1 MCF2 FARP2

7.54e-0468493SM00325
DomainDH_2

TIAM1 MCF2 FARP2

8.21e-0470493PS50010
DomainRhoGEF

TIAM1 MCF2 FARP2

8.21e-0470493PF00621
DomainDH-domain

TIAM1 MCF2 FARP2

8.56e-0471493IPR000219
Domain-

TIAM1 MCF2 FARP2

8.56e-04714931.20.900.10
DomainMMR_HSR1

GNL3 DRG1

8.94e-0417492PF01926
DomainGTP_binding_domain

GNL3 DRG1

1.12e-0319492IPR006073
DomainEz/rad/moesin-like

FRMD7 FARP2

1.37e-0321492IPR000798
DomainFERM_CS

FRMD7 FARP2

1.79e-0324492IPR019747
DomainC2H2_Znf_fam

ZSCAN5A PLAGL2

1.79e-0324492IPR027775
DomainFERM_C

FRMD7 FARP2

2.11e-0326492PF09380
DomainFERM_C

FRMD7 FARP2

2.27e-0327492SM01196
DomainFERM_PH-like_C

FRMD7 FARP2

2.27e-0327492IPR018980
DomainPH

TIAM1 MCF2 CNKSR2 FARP2

3.03e-03229494PF00169
DomainFERM_N

FRMD7 FARP2

3.38e-0333492IPR018979
DomainFERM_N

FRMD7 FARP2

3.38e-0333492PF09379
Domain-

TIAM1 FRMD7 MCF2 CNKSR2 FARP2

3.51e-033914952.30.29.30
DomainPH_dom-like

TIAM1 FRMD7 MCF2 CNKSR2 FARP2

5.04e-03426495IPR011993
DomainABC_transporter_CS

ABCA12 ABCD3

5.43e-0342492IPR017871
DomainPH

TIAM1 MCF2 CNKSR2 FARP2

6.02e-03278494SM00233
DomainPH_DOMAIN

TIAM1 MCF2 CNKSR2 FARP2

6.09e-03279494PS50003
DomainPH_domain

TIAM1 MCF2 CNKSR2 FARP2

6.17e-03280494IPR001849
DomainFERM_M

FRMD7 FARP2

6.48e-0346492PF00373
DomainABC_TRANSPORTER_2

ABCA12 ABCD3

7.04e-0348492PS50893
DomainABC_tran

ABCA12 ABCD3

7.04e-0348492PF00005
DomainFERM_central

FRMD7 FARP2

7.33e-0349492IPR019748
DomainABC_TRANSPORTER_1

ABCA12 ABCD3

7.33e-0349492PS00211
DomainFERM_domain

FRMD7 FARP2

7.33e-0349492IPR000299
Domain-

FRMD7 FARP2

7.33e-03494921.20.80.10
DomainFERM_1

FRMD7 FARP2

7.62e-0350492PS00660
DomainFERM_2

FRMD7 FARP2

7.62e-0350492PS00661
DomainBand_41_domain

FRMD7 FARP2

7.62e-0350492IPR019749
DomainB41

FRMD7 FARP2

7.62e-0350492SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD7 FARP2

7.62e-0350492IPR014352
PathwayREACTOME_RHOA_GTPASE_CYCLE

STARD8 TIAM1 ABCD3 MCF2

2.01e-04149284M41805
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA12 ABCD3

5.08e-0417282MM14552
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCA12 ABCD3

5.71e-0418282M524
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

NOP14 ABCD3 SRP68 NKTR GMEB2 GNL3

8.77e-0633051633301849
Pubmed

Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

CLCN1 ABCA12

1.26e-05451226552429
Pubmed

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.

FLII TIAM1

1.26e-05451226887924
Pubmed

The DNA sequence of the human X chromosome.

STARD8 EFNB1 FRMD7 MCF2 CNKSR2 ZXDA

2.86e-0540751615772651
Pubmed

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.

EFNB1 TIAM1

5.87e-05851214988728
Pubmed

The LMO2 oncogene regulates DNA replication in hematopoietic cells.

FLII APPBP2 DRG1

8.66e-055851326764384
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

NOP14 ACACB ABCD3 SRP68 NKTR GMEB2 RREB1 GNL3 DRG1

1.14e-04131851930463901
Pubmed

RhoG signals in parallel with Rac1 and Cdc42.

TIAM1 MCF2

1.63e-041351212376551
Pubmed

In vivo dual-tagging proteomic approach in studying signaling pathways in immune response.

FLII OBI1

2.83e-041751215952741
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF765 SP100 NOP14 EFNB1 ABCD3 SLC35E1 ZNF468 ZNF467

3.40e-04120351829180619
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

STARD8 TIAM1 ABCD3 MCF2 CNKSR2 NKTR FARP2

3.63e-0491651732203420
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

ABCD3 SRP68 GNL3 DRG1

3.71e-0423151436597993
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

FLII NOP14 SRP68 RIC8A GNL3 DRG1

3.76e-0465351633742100
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

EFNB1 TIAM1 ABCD3 SLC35E1 DRG1

6.04e-0446751530194290
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TIAM1 IFT172 ABCD3 SLC35E1 SRP68 NKTR RREB1 DRG1

6.31e-04132151827173435
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SLC35E1 SRP68 RREB1 GNL3 ELP4 FARP2

6.90e-0473351634672954
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

SLF2 ZSCAN5A RREB1

8.32e-0412551332891193
Pubmed

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

TIAM1 ABCA12 SMIM29

1.02e-0313451324324551
Pubmed

Human transcription factor protein interaction networks.

KANSL2 NOP14 ACACB ABCD3 SRP68 GMEB2 RREB1 GNL3

1.05e-03142951835140242
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

SRP68 OBI1 GNL3 DRG1

1.19e-0331651431665637
Pubmed

Next-generation sequencing to generate interactome datasets.

SP100 APPBP2 ZBTB8A NIF3L1 RIC8A OBI1 DRG1

1.36e-03114751721516116
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

SLF2 FRMD7 GNL3

1.38e-0314951322664934
Pubmed

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

NOP14 ABCD3 ELP4

1.41e-0315051322678362
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

FLII SP100 SRP68 GNL3

1.43e-0333251425693804
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

TIAM1 MCF2

1.43e-033851211756498
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF765 ZNF600 ZNF425 ZSCAN5A ZNF805 ZBTB8A PLAGL2 ZNF468 RREB1 ZNF467 ZXDA

2.16e-08718321128
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 MCF2 FARP2

2.14e-0466323722
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD7 FARP2

3.53e-03503221293
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 CNKSR2 FARP2

5.67e-03206323682
DiseasePancreatic Ductal Adenocarcinoma

ACACB ABCA12

1.35e-0411472C1335302
DiseaseColorectal Carcinoma

STARD8 TIAM1 ABCA12 ZSCAN5A ABCD3 CNKSR2

8.31e-04702476C0009402
Diseaseemphysema imaging measurement

ZNF600 TIAM1 CNKSR2

1.64e-03146473EFO_0007626
DiseaseGastrointestinal Stromal Sarcoma

IFT172 ELP4

2.56e-0347472C3179349
DiseaseGastrointestinal Stromal Tumors

IFT172 ELP4

2.90e-0350472C0238198
Diseaseattention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder

EFNB1 CNKSR2

3.01e-0351472EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090
Diseaserheumatoid arthritis, COVID-19

SMIM29 MIGA1

4.70e-0364472EFO_0000685, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
HKLLRRLHLMPFKDR

ABCA12

2371

Q86UK0
HRAASHRLKLVKVLS

ABHD12B

151

Q7Z5M8
FAKVLRALDKRHLLH

APPBP2

66

Q92624
HRRRAKELKHKSQHL

GMEB2

326

Q9UKD1
FKSVKLALEHLLRKR

ODF2L

106

Q9ULJ1
LVKRGREHKKLDLHR

ACACB

226

O00763
LSHFKRKFIIHRGKR

FLII

1031

Q13045
HHLGLLKARLAKLRR

DRG1

26

Q9Y295
AKIRKLSFKRKHFLI

FRMD7

226

Q6ZUT3
ALHHNLKRRVIERFK

NEK10

1051

Q6ZWH5
HTVRKHLRKTRLELL

OBI1

81

Q5W0B1
FTRKKNLHRKVLKLH

POLG2

361

Q9UHN1
RLIHKHKREFKGAVR

NOP14

791

P78316
KAFLRLVRKLHKCVS

MAB21L3

306

Q8N8X9
TGHKLLFRDRKLRLH

IFT172

496

Q9UG01
LLLKLRKRHRKHTQQ

EFNB1

261

P98172
RKLKHRLRLDSYLLK

MCF2

616

P10911
REHHRKLRKEAKKRG

GNL3

26

Q9BVP2
HLLKEKKRRYLHNRK

KANSL2

216

Q9H9L4
FKLKRKLFTIERLHL

ELP4

371

Q96EB1
RKLSFKRKRFLIKLH

FARP2

271

O94887
VIFLAHHFKRKRGKK

MIGA1

86

Q8NAN2
KRRRKLRKAAHLEVH

PHTF2

201

Q8N3S3
KHCRRHKQTKKRRIL

NKTR

446

P30414
VQKKKRVDRLRHHLL

SMIM29

41

Q86T20
KKHRSPERRKSLFIH

SLF2

166

Q8IX21
IFSKKVLRDSRIHHL

SLC35E1

206

Q96K37
IDRIKRHLKLSHIRL

NIF3L1

266

Q9GZT8
RALLIFLEKRLHKTH

RIC8A

311

Q9NPQ8
KRFHLLSRLRKAVKH

SRP68

151

Q9UHB9
KKRHRNRSFLKHLES

STARD8

121

Q92502
QRFGRKDHLTRHVKK

PLAGL2

226

Q9UPG8
LHKRRRALGLHGKKS

ABCD3

26

P28288
KRHRERVALAKDHLK

CFAP210

206

Q0VFZ6
VRKHKALSQFLAKHR

CLCN1

376

P35523
KLHRLRILKSTLKAR

CNKSR2

951

Q8WXI2
VKRKADLKRHLRCHT

ZBTB8A

291

Q96BR9
FLKAVHSILRDKHRR

TIAM1

1386

Q13009
HSILRDKHRRQLLKT

TIAM1

1391

Q13009
RHLRKKHLKATRKDI

RREB1

716

Q92766
KRHTHRKQRRKPTFL

SPIN4

21

Q56A73
LEKHSGKRRKKRRHR

SP100

526

P23497
KHKRRRSFSKKRRHS

SRRM4

141

A7MD48
AFSRLKLLRRHQKTH

ZSCAN5A

476

Q9BUG6
KLLRHKRKHDDDRRF

ZXDA

466

P98168
KAFHFKSKLQIHRRI

ZNF765

306

Q7L2R6
SKKIDFHLHVLRRKG

ZFAND4

171

Q86XD8
VFSRKSHLKRHRRIH

ZNF600

646

Q6ZNG1
VRRDLLKHKRSHSKS

ZNF425

201

Q6IV72
KVFSRKSHLERHKRI

ZNF468

306

Q5VIY5
VFNKKRLLARHERIH

ZNF805

211

Q5CZA5
ECEKRFRKKTHLIRH

ZNF467

276

Q7Z7K2