Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	CACNA1A HSPG2 ABI3BP MINK1 SPG11 USH1C NEFM PPP3CA PPP3CB FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	1.43e-05	748	113	15	GO:0048667
GeneOntologyBiologicalProcess	cell morphogenesis	CACNA1A VIL1 HSPG2 ABI3BP MINK1 SPG11 USH1C NEFM PPP3CA LATS2 PPP3CB FEZF1 HPN NR2E1 SLITRK5 KNDC1 PAK2 CDH15 DNM2	2.50e-05	1194	113	19	GO:0000902
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	CACNA1A VIL1 HSPG2 ABI3BP MINK1 SPG11 NEFM PPP3CA PPP3CB FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	4.08e-05	819	113	15	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	CACNA1A VIL1 HSPG2 ABI3BP MINK1 SPG11 NEFM PPP3CA PPP3CB FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	4.50e-05	826	113	15	GO:0048858
GeneOntologyBiologicalProcess	regulation of cell projection size	VIL1 USH1C NEFM	5.58e-05	14	113	3	GO:0032536
GeneOntologyBiologicalProcess	neuron projection development	CACNA1A HSPG2 ABI3BP MYOC MINK1 TSC1 SPG11 USH1C NEFM PBRM1 PPP3CA PPP3CB ALMS1 FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	6.75e-05	1285	113	19	GO:0031175
GeneOntologyBiologicalProcess	negative regulation of G protein-coupled receptor signaling pathway	PPP3CA DNM1 ATP2B4 DNM2 MGRN1	8.30e-05	81	113	5	GO:0045744
GeneOntologyBiologicalProcess	actin filament bundle assembly	VIL1 MYOC TSC1 USH1C ALMS1 PAK2 DNM2	8.83e-05	191	113	7	GO:0051017
GeneOntologyBiologicalProcess	vesicle scission	DNM1 DNM2	8.89e-05	3	113	2	GO:0099050
GeneOntologyBiologicalProcess	dendrite development	CACNA1A ABI3BP MINK1 PBRM1 PPP3CA NR2E1 SLITRK5 KNDC1 PAK2	9.59e-05	335	113	9	GO:0016358
GeneOntologyBiologicalProcess	regulation of calcineurin-NFAT signaling cascade	RCAN1 PPP3CA PPP3CB ATP2B4	9.79e-05	44	113	4	GO:0070884
GeneOntologyBiologicalProcess	actin filament bundle organization	VIL1 MYOC TSC1 USH1C ALMS1 PAK2 DNM2	1.01e-04	195	113	7	GO:0061572
GeneOntologyBiologicalProcess	regulation of calcineurin-mediated signaling	RCAN1 PPP3CA PPP3CB ATP2B4	1.07e-04	45	113	4	GO:0106056
GeneOntologyBiologicalProcess	dendrite morphogenesis	CACNA1A ABI3BP MINK1 PPP3CA NR2E1 SLITRK5 KNDC1	1.11e-04	198	113	7	GO:0048813
GeneOntologyBiologicalProcess	neuron development	CACNA1A HSPG2 ABI3BP MYOC MINK1 TSC1 SPG11 USH1C NEFM PBRM1 PPP3CA TENM4 PPP3CB ALMS1 FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	1.25e-04	1463	113	20	GO:0048666
GeneOntologyBiologicalProcess	neuron projection morphogenesis	CACNA1A HSPG2 ABI3BP MINK1 SPG11 NEFM PPP3CA PPP3CB FEZF1 NR2E1 SLITRK5 KNDC1 PAK2 DNM2	1.25e-04	802	113	14	GO:0048812
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1A PPP3CA PPP3CB ATP2B4	1.38e-04	48	113	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1A PPP3CA PPP3CB ATP2B4	1.38e-04	48	113	4	GO:1902656
GeneOntologyBiologicalProcess	skeletal muscle fiber development	RCAN1 SPG11 PPP3CA PPP3CB	1.50e-04	49	113	4	GO:0048741
GeneOntologyBiologicalProcess	late viral transcription	USF1 USF2	1.77e-04	4	113	2	GO:0019086
GeneOntologyBiologicalProcess	calcineurin-NFAT signaling cascade	RCAN1 PPP3CA PPP3CB ATP2B4	2.19e-04	54	113	4	GO:0033173
GeneOntologyBiologicalProcess	myotube cell development	RCAN1 SPG11 PPP3CA PPP3CB	2.19e-04	54	113	4	GO:0014904
GeneOntologyBiologicalProcess	calcineurin-mediated signaling	RCAN1 PPP3CA PPP3CB ATP2B4	2.88e-04	58	113	4	GO:0097720
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	CACNA1A VIL1 HSPG2 ABI3BP TFRC NEFM PPP3CA TENM4 HPN DDHD1 NR2E1 KNDC1 PAK2 ATP2B4 GAB1 SMAD1	2.93e-04	1090	113	16	GO:0022603
MousePheno	pericardial effusion	HSPG2 KMT2B ADAMTS3 TSC1 TFRC LATS2 GAB1 MGRN1	1.24e-06	111	100	8	MP:0005312
MousePheno	effusion	HSPG2 KMT2B ADAMTS3 TSC1 TFRC LATS2 GAB1 MGRN1	1.30e-05	152	100	8	MP:0021205
MousePheno	abnormal pericardium morphology	HSPG2 KMT2B ADAMTS3 TSC1 TFRC LATS2 GAB1 SMAD1 MGRN1	3.30e-05	225	100	9	MP:0000288
Domain	BTP	TAF8 TAF3	1.14e-04	3	116	2	SM00576
Domain	BTP	TAF8 TAF3	1.14e-04	3	116	2	IPR006565
Domain	Bromo_TP	TAF8 TAF3	1.14e-04	3	116	2	PF07524
Domain	NUT	NUTM2G NUTM2F	3.78e-04	5	116	2	IPR024310
Domain	NUT_N	NUTM2G NUTM2F	3.78e-04	5	116	2	IPR024309
Domain	NUT	NUTM2G NUTM2F	3.78e-04	5	116	2	PF12881
Domain	Dynamin_central	DNM1 DNM2	5.64e-04	6	116	2	IPR000375
Domain	GED	DNM1 DNM2	5.64e-04	6	116	2	SM00302
Domain	DDHD	DDHD1 PITPNM3	5.64e-04	6	116	2	PF02862
Domain	DDHD	DDHD1 PITPNM3	5.64e-04	6	116	2	PS51043
Domain	DDHD_dom	DDHD1 PITPNM3	5.64e-04	6	116	2	IPR004177
Domain	Dynamin_M	DNM1 DNM2	5.64e-04	6	116	2	PF01031
Domain	GED_dom	DNM1 DNM2	5.64e-04	6	116	2	IPR020850
Domain	GED	DNM1 DNM2	5.64e-04	6	116	2	PS51388
Domain	Dynamin_GTPase_CS	DNM1 DNM2	5.64e-04	6	116	2	IPR019762
Domain	GED	DNM1 DNM2	5.64e-04	6	116	2	PF02212
Domain	GED	DNM1 DNM2	5.64e-04	6	116	2	IPR003130
Domain	DDHD	DDHD1 PITPNM3	5.64e-04	6	116	2	SM01127
Domain	G_DYNAMIN_1	DNM1 DNM2	7.87e-04	7	116	2	PS00410
Domain	DYNc	DNM1 DNM2	7.87e-04	7	116	2	SM00053
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1A MINK1 KSR2 TSC1 NOL9 NEFM PBRM1 PPP3CA PPP3CB FAM120A RAB3IP PAK2 CEP131 HERC2 DNM1 ATP2B4 CEP170B DNM2	5.23e-09	963	119	18	28671696
Pubmed	Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.	RCAN1 PPP3CA PPP3CB	1.56e-07	4	119	3	12809556
Pubmed	Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.	PPP3CA PPP3CB ATP2B4	1.56e-07	4	119	3	19287093
Pubmed	TTP specifically regulates the internalization of the transferrin receptor.	TFRC DNM1 DNM2	7.75e-07	6	119	3	16325581
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MTMR12 RCAN1 MINK1 NUP98 PPP1R13B RNF213 TSC1 PPP3CA PPP3CB CEP131 POC5 HERC2 PLEKHA7 ATP2B4 GAB1	3.13e-06	1049	119	15	27880917
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1A PCLO MINK1 GPR37L1 NEFM PPP3CA RAB3IP PITPNM3 CEP170B	3.26e-06	347	119	9	17114649
Pubmed	A human MAP kinase interactome.	INTS6L ABI3BP NUP98 PPP1R13B HIPK3 CEP95 PAK2 HERC2 USF2 GAB1	7.08e-06	486	119	10	20936779
Pubmed	Multiple roles of integrin-α3 at the neuromuscular junction.	CACNA1A PCLO NEFM	8.40e-06	12	119	3	28386022
Pubmed	Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation.	USF1 USF2	1.16e-05	2	119	2	12663044
Pubmed	H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression.	USF1 USF2	1.16e-05	2	119	2	20180799
Pubmed	The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo.	USF1 USF2	1.16e-05	2	119	2	9053857
Pubmed	Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.	DNM1 DNM2	1.16e-05	2	119	2	21670293
Pubmed	Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study.	DNM1 DNM2	1.16e-05	2	119	2	16028072
Pubmed	Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.	PPP3CA PPP3CB	1.16e-05	2	119	2	19861587
Pubmed	Loss of Dynamin 2 GTPase function results in microcytic anaemia.	TFRC DNM2	1.16e-05	2	119	2	28466468
Pubmed	Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells.	USF1 USF2	1.16e-05	2	119	2	8127680
Pubmed	Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.	USF1 USF2	1.16e-05	2	119	2	7852331
Pubmed	Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.	PPP3CA PPP3CB	1.16e-05	2	119	2	19907416
Pubmed	Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.	PPP3CA PPP3CB	1.16e-05	2	119	2	8187553
Pubmed	Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.	PPP3CA PPP3CB	1.16e-05	2	119	2	1328240
Pubmed	Enzymatic and thermodynamic analysis of calcineurin inhibition by RCAN1.	RCAN1 PPP3CA	1.16e-05	2	119	2	25193101
Pubmed	Dynamin regulates L cell secretion in human gut.	DNM1 DNM2	1.16e-05	2	119	2	34274446
Pubmed	Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.	PPP3CA PPP3CB	1.16e-05	2	119	2	11005320
Pubmed	Exome sequencing identified rare variants in genes HSPG2 and ATP2B4 in a family segregating developmental dysplasia of the hip.	HSPG2 ATP2B4	1.16e-05	2	119	2	28327142
Pubmed	Undetectable histone O-GlcNAcylation in mammalian cells.	TET2 HCFC1	1.16e-05	2	119	2	26075789
Pubmed	Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.	PPP3CA PPP3CB	1.16e-05	2	119	2	2556704
Pubmed	Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice.	USF1 USF2	1.16e-05	2	119	2	9520440
Pubmed	An intramolecular signaling element that modulates dynamin function in vitro and in vivo.	DNM1 DNM2	1.16e-05	2	119	2	19515832
Pubmed	Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse.	USF1 USF2	1.16e-05	2	119	2	7774954
Pubmed	Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.	PPP3CA PPP3CB	1.16e-05	2	119	2	35247520
Pubmed	The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.	PPP3CA PPP3CB	1.16e-05	2	119	2	20810903
Pubmed	Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.	DNM1 DNM2	1.16e-05	2	119	2	22977254
Pubmed	Calcineurin A-alpha but not A-beta is required for normal kidney development and function.	PPP3CA PPP3CB	1.16e-05	2	119	2	15509543
Pubmed	Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.	RCAN1 PPP3CA	1.16e-05	2	119	2	24838101
Pubmed	TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.	TET2 LILRB1	1.16e-05	2	119	2	36812290
Pubmed	Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1).	USF1 USF2	1.16e-05	2	119	2	18845576
Pubmed	Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.	DNM1 DNM2	1.16e-05	2	119	2	25116793
Pubmed	Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.	USF1 USF2	1.16e-05	2	119	2	8576131
Pubmed	Dynamin at actin tails.	DNM1 DNM2	1.16e-05	2	119	2	11782545
Pubmed	Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.	USF1 USF2	1.16e-05	2	119	2	16870626
Pubmed	Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.	PPP3CA PPP3CB	1.16e-05	2	119	2	22739212
Pubmed	Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome.	VIL1 USH1C	1.16e-05	2	119	2	24250806
Pubmed	Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose.	USF1 USF2	1.16e-05	2	119	2	9685363
Pubmed	Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration.	SPG11 DNM1	1.16e-05	2	119	2	29949766
Pubmed	The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.	PPP3CA ATP2B4	1.16e-05	2	119	2	15955804
Pubmed	Are calcineurin genes associated with athletic status? A function, replication study.	PPP3CA PPP3CB	1.16e-05	2	119	2	21233773
Pubmed	Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.	USF1 USF2	1.16e-05	2	119	2	15242350
Pubmed	Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.	DNM1 DNM2	1.16e-05	2	119	2	32065700
Pubmed	Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.	PPP3CA PPP3CB	1.16e-05	2	119	2	25286016
Pubmed	[USF as a key regulatory element of gene expression].	USF1 USF2	1.16e-05	2	119	2	16386222
Pubmed	USF inhibits cell proliferation through delay in G2/M phase in FRTL-5 cells.	USF1 USF2	1.16e-05	2	119	2	17379962
Pubmed	Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.	PPP3CA PPP3CB	1.16e-05	2	119	2	25287476
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PMS2P2 MINK1 KSR2 RNF213 HIPK3 PPP3CA LATS2 FAM120A HPN RAB3IP KNDC1 USP15 SLC4A5 CEP170B FAM162A CDH15 MGRN1	1.30e-05	1489	119	17	28611215
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	PCLO NEFM HCFC1	1.38e-05	14	119	3	16452088
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	MTMR12 MINK1 NOL9 FAM120A DDHD1 TCF25 DNM1 DHX34 HCFC1 DNM2 MGRN1	1.52e-05	650	119	11	38777146
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	USF1 USF2 HCFC1	2.56e-05	17	119	3	21653943
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	USF1 USF2 HCFC1	3.07e-05	18	119	3	17846119
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CACNA1A PCLO MINK1 TSC1 NEFM PPP3CA TENM4 FAM120A KNDC1 DDX3Y CORO6 DNM1 PLEKHA7 ATP2B4 CEP170B DNM2	3.08e-05	1431	119	16	37142655
Pubmed	Upstream stimulatory factors are involved in the P1 promoter directed transcription of the A beta H-J-J locus.	USF1 USF2	3.47e-05	3	119	2	19087304
Pubmed	Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.	RCAN1 PPP3CB	3.47e-05	3	119	2	16648267
Pubmed	Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.	USF1 USF2	3.47e-05	3	119	2	21813151
Pubmed	Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.	PPP3CA PPP3CB	3.47e-05	3	119	2	12773574
Pubmed	Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.	USF1 USF2	3.47e-05	3	119	2	23653383
Pubmed	Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2.	USF1 USF2	3.47e-05	3	119	2	11945176
Pubmed	DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.	RCAN1 PPP3CA	3.47e-05	3	119	2	10861295
Pubmed	Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.	PPP3CA PPP3CB	3.47e-05	3	119	2	2162844
Pubmed	Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).	PPP3CA PPP3CB	3.47e-05	3	119	2	8392375
Pubmed	KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.	KSR2 PPP3CA	3.47e-05	3	119	2	19560418
Pubmed	Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.	TFRC PAK2	3.47e-05	3	119	2	15047825
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM1 DNM2	3.47e-05	3	119	2	12511974
Pubmed	Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.	PPP3CA PPP3CB	3.47e-05	3	119	2	21427212
Pubmed	PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex.	TSC1 PAK2	3.47e-05	3	119	2	26412398
Pubmed	Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo).	INPP5D GAB1	3.47e-05	3	119	2	11402314
Pubmed	USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells.	USF1 USF2	3.47e-05	3	119	2	12225970
Pubmed	SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.	DNM1 DNM2	3.47e-05	3	119	2	15703209
Pubmed	Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.	PPP3CA PPP3CB	3.47e-05	3	119	2	7593193
Pubmed	Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.	PPP3CA PPP3CB	3.47e-05	3	119	2	9655484
Pubmed	The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.	PPP3CA PPP3CB	3.47e-05	3	119	2	19154138
Pubmed	Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor.	USF1 USF2	3.47e-05	3	119	2	12970752
Pubmed	Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.	DNM1 DNM2	3.47e-05	3	119	2	24145164
Pubmed	Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes.	USF1 USF2	3.47e-05	3	119	2	15187018
Pubmed	Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin.	USF1 USF2	3.47e-05	3	119	2	17823260
Pubmed	Archaic structure of the gene encoding transcription factor USF.	USF1 USF2	3.47e-05	3	119	2	7523363
Pubmed	Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells.	USF1 USF2	3.47e-05	3	119	2	23749757
Pubmed	Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes.	PPP3CA PPP3CB	3.47e-05	3	119	2	20359506
Pubmed	Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis.	USF1 USF2	3.47e-05	3	119	2	18165439
Pubmed	Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.	USF1 USF2	3.47e-05	3	119	2	15983197
Pubmed	TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.	USF1 USF2	3.47e-05	3	119	2	15767439
Pubmed	Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1.	USF1 USF2	3.47e-05	3	119	2	12611894
Pubmed	Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency.	TET2 KMT2B	3.47e-05	3	119	2	31844322
Pubmed	Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2.	USF1 USF2	3.47e-05	3	119	2	18758746
Pubmed	O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2.	USF1 USF2	3.47e-05	3	119	2	16199862
Pubmed	Dynamin and endocytosis.	DNM1 DNM2	3.47e-05	3	119	2	12383797
Pubmed	Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.	RCAN1 PPP3CA	3.47e-05	3	119	2	12515860
Pubmed	Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.	DNM1 DNM2	3.47e-05	3	119	2	22371560
Pubmed	Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.	PPP3CA PPP3CB	3.47e-05	3	119	2	20700529
Pubmed	Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.	NUP98 TFRC	3.47e-05	3	119	2	23958061
Pubmed	Calcineurin protects the heart in a murine model of dilated cardiomyopathy.	PPP3CA PPP3CB	3.47e-05	3	119	2	19854199
Pubmed	Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.	PPP3CA PPP3CB	3.47e-05	3	119	2	8978785
Pubmed	Upstream stimulating factors regulate the expression of RORγT in human lymphocytes.	USF1 USF2	3.47e-05	3	119	2	22891280
Interaction	PLK2 interactions	TSC1 RABL6 TAF8 PAK2 DNM1 DNM2	3.26e-06	70	117	6	int:PLK2
Interaction	PSG1 interactions	PPT2 SLITRK5 USF1 USF2 MGRN1	1.15e-05	51	117	5	int:PSG1
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	ADAMTS3 CD248 ADTRP NEFM TENM4 NYNRIN DNM1	1.53e-05	148	114	7	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k4_500
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 PCLO SAMD5 ADTRP TENM4 LATS2 IL1RAPL2	1.07e-06	200	118	7	1a3d29a580d1b405a74869a1da3e818c581fc559
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E---L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 PCLO SAMD5 ADTRP TENM4 LATS2 IL1RAPL2	1.07e-06	200	118	7	6f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 PCLO SAMD5 ADTRP TENM4 LATS2 IL1RAPL2	1.07e-06	200	118	7	86705dfc05b3e1576543b93883c88fb55b742855
ToppCell	Neuronal-Excitatory-eB(RORB)-SEMA3E\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC9A9 PCLO SAMD5 ADTRP TENM4 LATS2 IL1RAPL2	1.07e-06	200	118	7	db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1A VIL1 PCLO USH1C NUTM2G HPN	1.00e-05	185	118	6	d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A PCLO PPP3CA PITPNM3 DNM1 CDH15	1.03e-05	186	118	6	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PCLO SAMD5 CSF3R HPN KNDC1 ROS1	1.24e-05	192	118	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A PCLO NEFM TENM4 DNM1 ATP2B4	1.27e-05	193	118	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A PCLO NEFM TENM4 DNM1 ATP2B4	1.27e-05	193	118	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A PCLO NEFM TENM4 DNM1 ATP2B4	1.27e-05	193	118	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KSR2 NEU2 TENM4 SLITRK5 DDX3Y CDH15	1.27e-05	193	118	6	1aa3ab528605dc7b2fec46e759c9d1ee93d59b11
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCLO KSR2 TCF25 HERC2 DNM1 CEP170B	1.31e-05	194	118	6	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	10x5'v1-week_12-13-Hematopoietic-erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MFSD2B RNF11 TFRC PPT2 GUK1 USP15	1.39e-05	196	118	6	0aae78e73d53416d857bdf21f595a0a0a0ba7944
ToppCell	5'-Adult-Distal_Rectal-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RABL6 FAM120A B4GALNT3 CEP170B FAM162A DNM2	1.47e-05	198	118	6	9c0535099750698daac5d6b4d39fb19fecf4ffde
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PCLO RNF11 PPP3CB TCF25 DNM1 CEP170B	1.52e-05	199	118	6	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MINK1 DARS2 PPT2 NYNRIN RECQL5 PITPNM3	1.56e-05	200	118	6	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM1 DNM2	1.47e-04	5	114	2	DOID:0111223 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM1 DNM2	1.47e-04	5	114	2	DOID:11252 (implicated_via_orthology)
Disease	chronic myelomonocytic leukemia (is_implicated_in)	TET2 CSF3R	1.47e-04	5	114	2	DOID:0080188 (is_implicated_in)
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM1 DNM2	1.47e-04	5	114	2	DOID:0110197 (implicated_via_orthology)
Disease	serum IgG glycosylation measurement	SLC9A9 MEF2B SAMD5 RALGAPA2 TAF3 CEP131 USP15 DHX34 CEP170B	2.01e-04	523	114	9	EFO_0005193
Disease	focal segmental glomerulosclerosis (is_marker_for)	PPP3CA PPP3CB	4.08e-04	8	114	2	DOID:1312 (is_marker_for)
Disease	obsolete_red blood cell distribution width	KMT2B MFSD2B APEH NOL9 TFRC PBRM1 C1orf105 PAK2 USF2 NUTM2F ATP2B4 CDH15 SMAD1 DNM2	7.02e-04	1347	114	14	EFO_0005192
Disease	Liver carcinoma	TICRR DCAF4L2 KMT2B RCAN1 TSC1 RTP3 PITPNM3 CEP131	8.07e-04	507	114	8	C2239176
Disease	collagen disease (implicated_via_orthology)	DNM1 DNM2	9.52e-04	12	114	2	DOID:854 (implicated_via_orthology)
Disease	pulse pressure measurement	TET2 LYPLAL1 RNF213 ACAD10 ZNF831 PBRM1 PPP3CA TENM4 LATS2 PITPNM3 POC5 PLEKHA7 DHX34 HCFC1	9.64e-04	1392	114	14	EFO_0005763
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM1 DNM2	1.12e-03	13	114	2	DOID:0112202 (implicated_via_orthology)
Disease	lymphocyte count	TET2 MINK1 MFSD2B ACAD10 ADTRP ZNF831 ITGB7 TAF8 PBRM1 TENM4 PPT2 ALMS1 PAK2 ATP2B4	1.55e-03	1464	114	14	EFO_0004587
Disease	fish consumption measurement	ACAD10 TENM4 FEZF1	1.97e-03	64	114	3	EFO_0010139
Disease	response to ziprasidone	PPP3CA TENM4	2.69e-03	20	114	2	GO_0097337
Disease	autism spectrum disorder (implicated_via_orthology)	SLC9A9 MEF2B TSC1 PAK2	2.91e-03	152	114	4	DOID:0060041 (implicated_via_orthology)
Disease	platelet-to-lymphocyte ratio	VIL1 MINK1 MFSD2B ACAD10 ZNF831 PPT2	2.91e-03	363	114	6	EFO_0008446
Disease	Hepatolenticular Degeneration	PPP3CA PPP3CB	3.86e-03	24	114	2	C0019202
Disease	Hepatic Form of Wilson Disease	PPP3CA PPP3CB	3.86e-03	24	114	2	C1527352

Protein segments in the cluster

Peptide	Gene	Start	Entry
TAEVHPVPLRKPKYD	USH1C	391	Q9Y6N9
STPRPHVSYSPVIRK	CACNA1A	2291	O00555
YLHIAKPAIPTPLEV	CFAP61	1051	Q8NHU2
PSKPVAEYLTRPHLG	TFAP2C	326	Q92754
SDIPRPKHTPISYVL	ANO5	156	Q75V66
PKHTPISYVLGPVRL	ANO5	161	Q75V66
PRDTLYRVPLIPKSH	B4GALNT3	326	Q6L9W6
PRVPYHSSVLSVTRP	CD248	436	Q9HCU0
IPILPSTFYSHTEKP	ALMS1	1326	Q8TCU4
PITLAEVVLRPHSYP	ADTRP	136	Q96IZ2
YKDPSLPGLEPSHRR	ACAD10	371	Q6JQN1
LAPKRSEALPEHTPY	CEP170B	126	Q9Y4F5
SPTKLTPIVHSPLRY	PPP1R13B	671	Q96KQ4
HYRQIPSPDVFLPKV	ATP2B4	486	P23634
PKIIQTRRPEYTPIH	RCAN1	236	P53805
IILHVESPPYATTVP	HSPG2	3291	P98160
IYRPHPSALSSVPIQ	RAB3IP	56	Q96QF0
NYILRELPKVPTHVP	RABL6	156	Q3YEC7
PSYPNLIKPTLVHTD	INTS6L	656	Q5JSJ4
LPPPRESHTAVVYTE	HCFC1	196	P51610
YHILTPVPPEELRTV	NOL9	621	Q5SY16
IPQATAAKYPRTIHP	POC5	531	Q8NA72
TPTHYKLTPRPATRV	NUP98	546	P52948
APPPKTQRLLHSEAY	PBRM1	1596	Q86U86
DIRKQPAPYVPTISH	LATS2	981	Q9NRM7
PKPSFVSYVRPEEIH	MTMR12	16	Q9C0I1
ELIGYPPPSSSSHIK	HERC2	2626	O95714
SPVPINLRVYSPHVL	DNM1	116	Q05193
LPRSYSHDVLPKVSP	GAB1	261	Q13480
PSTPVNPLRLDVTYH	MGAM	1031	O43451
PYVTPAPHEPVKTLR	MGRN1	71	O60291
PPRYSDLHISQTLPK	KSR2	486	Q6VAB6
GLTTPELRVYPHKTL	DCAF4L2	106	Q8NA75
LTTSKHAEPPYRIPS	PCLO	2826	Q9Y6V0
VPEKHLTLPPQSRDY	FAM221B	101	A6H8Z2
YPSKVHILPRPLEST	MYOC	311	Q99972
LTTRHPPYLKLVISF	MFSD2B	276	A6NFX1
EAHLKIYESVLTPPP	KMT2B	656	Q9UMN6
KHTPLYERSSPINPA	FAM120A	426	Q9NZB2
TNIYKPVLDIPHLRP	RALGAPA2	261	Q2PPJ7
PHLRPKPVYITTTRD	RALGAPA2	271	Q2PPJ7
SPVPINLRVYSPHVL	DNM2	116	P50570
RLLPSPTIHQTQYKP	HIPK3	1171	Q9H422
HLTSKTPPPLYLPTE	MEF2B	191	Q02080
VHLSSPLPLTEYIQP	HPN	261	P05981
VLPFVSTVPSKLRHP	ITGB7	201	P26010
YAKPRLPLPVFTVRH	MYO15B	136	Q96JP2
YRKLHPIQRPIPSAF	NEU2	181	Q9Y3R4
LAAPAPHRASYKPVI	PPT2	26	Q9UMR5
PVIAPRPDHTKSIYT	PAK2	181	Q13177
PTSLVPYHSETPAKK	ADAMTS3	1086	O15072
RPIYISVQPPSLHVL	GUK1	116	Q16774
LTLVPYTLVRPHRPA	CARD14	811	Q9BXL6
YPEPSKLPHTVSLET	GFY	66	I3L273
SSIYFHKPRESPPLL	GPR37L1	461	O60883
RPLIDLTIPPKTKYH	C1orf100	51	Q5SVJ3
RKPPYRSHSLSPSPV	CEP95	441	Q96GE4
PVLISLRDGYVPPKH	CORO6	386	Q6QEF8
PPELGKSPLTHYTIF	CSF3R	551	Q99062
FQHIKIIYPTAPPRS	LYPLAL1	51	Q5VWZ2
LPPHKERPYTIAAAL	KNDC1	1426	Q76NI1
IPSPVTSPVLSRRHY	DDHD1	721	Q8NEL9
TRYTRPTPVQKHAIP	DDX3Y	196	O15523
RPRSLYIPPVHKDVE	C4orf54	1366	D6RIA3
YIPPVHKDVERTQPL	C4orf54	1371	D6RIA3
PKHSIPALADLPRTY	DHX34	86	Q14147
PFLRVLESIDHKYPP	DHX34	361	Q14147
VVKAVPFPPTHRLTS	PPP3CB	26	P16298
PISVSENHKRLPYPL	CDH15	51	P55291
VHNRYTPSERAPPLK	CEP131	186	Q9UPN4
RVVKAVPFPPSHRLT	PPP3CA	16	Q08209
LTEPYIPHYTSLKPS	FAM166A	81	Q6J272
LVSLAQPTPKYPHEV	NR2E1	156	Q9Y466
GRKHPIAYTSKPLLP	NYNRIN	1181	Q9P2P1
SLVAHRVPLKPYAAP	MINK1	581	Q8N4C8
YKPLARRHLPQSPDT	NUTM2F	216	A1L443
YKPLARRHLPQSPDT	NUTM2G	216	Q5VZR2
VPVYHPTPSQTRLAT	RNF11	46	Q9Y3C5
LPPSQTPRVHSIYKV	RTP3	171	Q9BQQ7
SVSPPTPEPLHKVYE	TAF3	496	Q5VWG9
PHTYIKTPTYREPVS	TAF8	156	Q7Z7C8
VPPEELKPYHIRVSK	DARS2	621	Q6PI48
LTTSPVFPHYIEKPL	TRIM43	386	Q96BQ3
YLKPILTHSGPPLTT	SLC9A9	536	Q8IVB4
RLATKYHTVPLPPKG	TMEM126B	166	Q8IUX1
DGIHLSKPPYSRKVP	SAMD5	141	Q5TGI4
QSSKPYLLTHPSDPL	LILRB1	401	Q8NHL6
GTPKPKRPAILTYHD	NDRG2	56	Q9UN36
YKHEIPATTLPVPSL	IL1RAPL2	621	Q9NP60
KTPYPHPRGTTVSVK	PMS2P2	211	O95744
LSSPLHPQPKTYLAE	FEZF1	186	A0PJY2
YRPHPPQLRKVTSPL	PLEKHA7	891	Q6IQ23
HRPSLIPPVTFEVKA	INPP5D	291	Q92835
PRKLTPYTVVLHGPA	NLRP7	166	Q8WX94
LSPYVSPKESPFRHV	TFRC	686	P02786
PSRTYNRVPLHKPTD	FAM162A	51	Q96A26
HYKRVESPVLPPVLV	SMAD1	126	Q15797
PVRLLLYPKSTHALS	APEH	696	P13798
NKPLVLSLPRRYPHT	C1orf105	26	O95561
IPPASHVYSLKPKRV	RECQL5	641	O94762
PPSVLPSDITIYHLI	SPG11	1136	Q96JI7
DPVTFLPHLPRKSVV	RNF213	4721	Q63HN8
YLKTHPSGRDPETPI	VIL1	681	P09327
YVHISLPQATVTPPR	TSC1	406	Q92574
HTPQTPLYTPERLQK	TICRR	1126	Q7Z2Z1
ISLSEISPPRFPIYH	SLITRK5	71	O94991
KEVHIRVASPPIKYP	PPAT	411	Q06203
SLPPVLVVHLKRFSY	USP15	826	Q9Y4E8
YKSVLRISLTHPTIP	TENM4	1071	Q6N022
IHIGLPVPTYPQRKT	SLC4A5	31	Q9BY07
KTVSRPSYVVKPLHP	ROS1	146	P08922
QRTIAPRTHPYSPKI	USF2	211	Q15853
PRTHPYSPKIDGTRT	USF2	216	Q15853
KASPPSLEQPYLTHR	WDR46	431	O15213
KFHLVPPVSVPRYQR	PITPNM3	451	Q9BZ71
HRKVTTELLVYYPPP	VSIG10	211	Q8N0Z9
LTTSPVFPHYIEKPL	TRIM43B	386	A6NCK2
SVDIQPPITPRYSHT	LCMT2	576	O60294
PTVFLKALPIPLYHT	ZNF831	51	Q5JPB2
SYTTPAPKDVLLPHK	ABI3BP	571	Q7Z7G0
PLSKLSLPPIHTLYQ	TET2	1666	Q6N021
HLLSPVATELVPYTP	UPK3B	76	Q9BT76
PGPAPLSSRKHVLYV	TCF25	166	Q9BQ70
PSRNPKEHLSSPVYI	TMEM14EP	56	Q6UXP3
RSIAPRTHPYSPKSE	USF1	176	P22415
RTHPYSPKSEAPRTT	USF1	181	P22415
YLSKLIPHAVLPPTV	KIAA1522	291	Q9P206
GPLYTHRPPITISSK	NEFM	421	P07197