Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC4A3 SLC4A2	2.71e-04	13	38	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC4A3 SLC4A2	2.71e-04	13	38	2	GO:0140829
GeneOntologyBiologicalProcess	amelogenesis	AMELX RELT SLC4A2	2.54e-05	32	37	3	GO:0097186
Domain	DUF3697	UBAP2 UBAP2L	3.82e-06	2	37	2	PF12478
Domain	DUF3697_Uba2	UBAP2 UBAP2L	3.82e-06	2	37	2	IPR022166
Domain	Anion_exchange_CS	SLC4A3 SLC4A2	1.14e-05	3	37	2	IPR018241
Domain	Anion_exchange	SLC4A3 SLC4A2	3.80e-05	5	37	2	IPR001717
Domain	ANION_EXCHANGER_2	SLC4A3 SLC4A2	7.97e-05	7	37	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A3 SLC4A2	7.97e-05	7	37	2	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A3 SLC4A2	1.36e-04	9	37	2	IPR013769
Domain	Band_3_cyto	SLC4A3 SLC4A2	1.36e-04	9	37	2	PF07565
Domain	-	SLC4A3 SLC4A2	1.36e-04	9	37	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A3 SLC4A2	1.70e-04	10	37	2	IPR016152
Domain	HCO3_cotransp	SLC4A3 SLC4A2	1.70e-04	10	37	2	PF00955
Domain	HCO3_transpt_euk	SLC4A3 SLC4A2	1.70e-04	10	37	2	IPR003020
Domain	HCO3_transpt_C	SLC4A3 SLC4A2	1.70e-04	10	37	2	IPR011531
Domain	UBA	UBAP2 UBAP2L	1.60e-03	30	37	2	SM00165
Domain	UBA	UBAP2 UBAP2L	2.31e-03	36	37	2	PF00627
Domain	UBA	UBAP2 UBAP2L	3.43e-03	44	37	2	IPR015940
Domain	UBA	UBAP2 UBAP2L	3.90e-03	47	37	2	PS50030
Domain	Homeodomain-like	PDX1 RERE MEIS2 BARHL2	4.08e-03	332	37	4	IPR009057
Domain	Znf_CCCH	ZC3H12B RBM27	5.89e-03	58	37	2	IPR000571
Domain	ZF_C3H1	ZC3H12B RBM27	5.89e-03	58	37	2	PS50103
Domain	Ig_I-set	OBSCN NEO1 LRRC4C	6.24e-03	190	37	3	IPR013098
Domain	I-set	OBSCN NEO1 LRRC4C	6.24e-03	190	37	3	PF07679
Domain	UBA-like	UBAP2 UBAP2L	7.13e-03	64	37	2	IPR009060
Domain	IGv	OBSCN LRRC4C	9.68e-03	75	37	2	SM00406
Domain	Homeobox	PDX1 MEIS2 BARHL2	1.10e-02	234	37	3	PF00046
Domain	IGc2	OBSCN NEO1 LRRC4C	1.12e-02	235	37	3	SM00408
Domain	Ig_sub2	OBSCN NEO1 LRRC4C	1.12e-02	235	37	3	IPR003598
Domain	HOMEOBOX_1	PDX1 MEIS2 BARHL2	1.13e-02	236	37	3	PS00027
Domain	HOX	PDX1 MEIS2 BARHL2	1.14e-02	237	37	3	SM00389
Domain	Homeobox_dom	PDX1 MEIS2 BARHL2	1.17e-02	239	37	3	IPR001356
Domain	HOMEOBOX_2	PDX1 MEIS2 BARHL2	1.17e-02	239	37	3	PS50071
Domain	Ig-like_fold	OBSCN NEO1 LRRC4C NFATC3 SLC4A2	1.22e-02	706	37	5	IPR013783
Domain	Homeobox_metazoa	PDX1 BARHL2	1.37e-02	90	37	2	IPR020479
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A3 SLC4A2	1.14e-04	10	23	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A3 SLC4A2	1.14e-04	10	23	2	MM15073
Pubmed	Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.	SLC4A3 SLC4A2	1.16e-06	2	38	2	11248201
Pubmed	UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.	UBAP2 UBAP2L	1.16e-06	2	38	2	35633597
Pubmed	lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins.	UBAP2 UBAP2L	1.16e-06	2	38	2	12524348
Pubmed	cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.	SLC4A3 SLC4A2	1.16e-06	2	38	2	2294114
Pubmed	Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.	PDX1 MEIS2	3.48e-06	3	38	2	11834421
Pubmed	Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo.	SLC4A3 SLC4A2	3.48e-06	3	38	2	7592657
Pubmed	Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.	SLC4A3 SLC4A2	3.48e-06	3	38	2	11208611
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	HIVEP1 KMT2E UBAP2L STARD9 SLC39A7	5.42e-06	233	38	5	37704626
Pubmed	Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.	SLC4A3 SLC4A2	6.96e-06	4	38	2	11842009
Pubmed	DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex.	PDX1 MEIS2	6.96e-06	4	38	2	11279116
Pubmed	Magnesium, pH regulation and modulation by mouse ameloblasts exposed to fluoride.	AMELX SLC4A2	6.96e-06	4	38	2	27744011
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	OBSCN UBAP2 RELT RBM27 MAP4K4 UBAP2L SLC39A7 MEIS2	1.20e-05	1021	38	8	26760575
Pubmed	Ameloblast Modulation and Transport of Cl⁻, Na⁺, and K⁺ during Amelogenesis.	AMELX SLC4A2	1.74e-05	6	38	2	26403673
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CACNA1B RICTOR NEO1 LRRC4C UBAP2 MAP4K4 UBAP2L SLC39A7	2.63e-05	1139	38	8	36417873
Pubmed	Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.	SLC4A3 SLC4A2	3.24e-05	8	38	2	26110920
Pubmed	Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3.	SLC4A3 SLC4A2	3.24e-05	8	38	2	7894173
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RICTOR HIVEP1 UBAP2 NFATC3 MAP4K4 STARD9 BRD4	3.59e-05	861	38	7	36931259
Pubmed	A census of human transcription factors: function, expression and evolution.	PDX1 HIVEP1 RERE FOXJ3 NFATC3 MEIS2 BARHL2	5.03e-05	908	38	7	19274049
Pubmed	Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.	PDX1 MEIS2	9.00e-05	13	38	2	17049510
Pubmed	NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.	NEO1 BARHL2	1.38e-04	16	38	2	27223328
Pubmed	Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.	CACNA1B MEIS2	1.38e-04	16	38	2	17444492
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	NEO1 RERE UBAP2 MAP4K4 UBAP2L SLC39A7 BRD4 SLC4A2	1.44e-04	1451	38	8	30550785
Pubmed	Analysis of the mTOR Interactome using SILAC technology revealed NICE-4 as a novel regulator of mTORC1 activity.	RICTOR UBAP2L	1.76e-04	18	38	2	34171383
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RICTOR HIVEP1 RERE MAP4K4 UBAP2L BRD4	1.79e-04	774	38	6	15302935
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	HIVEP1 RERE RBM27 BRD4	2.07e-04	268	38	4	33640491
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	NEO1 MEIS2	2.65e-04	22	38	2	37823339
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCNX1 UBAP2 RBM27 FOXJ3 MAP4K4	2.65e-04	529	38	5	14621295
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	PDX1 FOXJ3 NFATC3 MEIS2 BARHL2	3.01e-04	544	38	5	28473536
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	UBAP2 RBM27 MAP4K4 UBAP2L BRD4	3.14e-04	549	38	5	38280479
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ARFGEF1 RICTOR NEO1 MAP4K4 SLC4A2	3.70e-04	569	38	5	30639242
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ZSWIM8 HIVEP1 FOXJ3 NFATC3 SLC39A7 SLC4A2	4.65e-04	925	38	6	28986522
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	MEIS2 BARHL2	4.96e-04	30	38	2	25804738
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	CACNA1B AMELX	5.65e-04	32	38	2	19320717
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	PCNX1 BRD4	6.01e-04	33	38	2	19336002
Pubmed	mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.	AMELX RICTOR	6.38e-04	34	38	2	32866472
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	UBAP2 UBAP2L BRD4	6.41e-04	154	38	3	16055720
Pubmed	Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.	JARID2 BARHL2	7.15e-04	36	38	2	29891551
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	PDX1 BARHL2	7.56e-04	37	38	2	21362171
Pubmed	Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.	PDX1 RICTOR	8.40e-04	39	38	2	28576773
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	UBAP2 UBAP2L MEIS2 BRD4	9.25e-04	399	38	4	35987950
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RERE LRRC4C UBAP2L STARD9	9.96e-04	407	38	4	12693553
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	RICTOR RERE	1.02e-03	43	38	2	33472061
Pubmed	A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.	PCNX1 ZNF804B	1.02e-03	43	38	2	25130324
GeneFamily	Zinc fingers CCCH-type	ZC3H12B RBM27	1.43e-03	35	29	2	73
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN NEO1 LRRC4C	2.14e-03	161	29	3	593
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	JARID2 RICTOR HIVEP1 RERE KMT2E MAP4K4	1.20e-08	193	37	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	OBSCN KMT2E FOXJ3 NFATC3 UBAP2L	2.55e-07	166	37	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	JARID2 RICTOR HIVEP1 RERE KMT2E	5.24e-07	192	37	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	JARID2 RERE NFATC3 MAP4K4	1.68e-05	186	37	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	JARID2 RERE NFATC3 MAP4K4	1.68e-05	186	37	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	OBSCN CACNA1B LRRC4C SLC4A3	2.23e-05	200	37	4	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	lymphoid-T_cell-pro-T_cell\|World / Lineage, cell class and subclass	OBSCN ZSWIM8 INSL3	4.03e-05	80	37	3	9bd3ad5029eb84efcdbf08fe268c29fa9b0b302b
Disease	anemia (implicated_via_orthology)	SLC4A3 SLC4A2	1.68e-04	15	38	2	DOID:2355 (implicated_via_orthology)
Disease	Amelogenesis imperfecta	AMELX RELT	2.17e-04	17	38	2	cv:C0002452
Disease	Parkinson disease	CACNA1B RERE UBAP2 MAP4K4	7.58e-04	321	38	4	MONDO_0005180
Disease	stomach cancer (is_marker_for)	RICTOR MAP4K4 BARHL2	8.14e-04	142	38	3	DOID:10534 (is_marker_for)
Disease	colon cancer (is_implicated_in)	RICTOR BRD4	9.90e-04	36	38	2	DOID:219 (is_implicated_in)
Disease	schizophrenia, intelligence, self reported educational attainment	PCNX1 RERE KMT2E BARHL2	1.00e-03	346	38	4	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	colorectal cancer (is_marker_for)	RICTOR MAP4K4 BARHL2	1.09e-03	157	38	3	DOID:9256 (is_marker_for)
Disease	autistic disorder (is_implicated_in)	JARID2 KMT2E	1.35e-03	42	38	2	DOID:12849 (is_implicated_in)
Disease	Congenital Heart Defects	MEIS2 BRD4	1.48e-03	44	38	2	C0018798
Disease	esophagus squamous cell carcinoma (is_implicated_in)	FES RICTOR	1.54e-03	45	38	2	DOID:3748 (is_implicated_in)
Disease	lung adenocarcinoma (is_implicated_in)	FES MAP4K4	1.83e-03	49	38	2	DOID:3910 (is_implicated_in)
Disease	Heschl's gyrus morphology measurement	PCNX1 ZNF804B	2.14e-03	53	38	2	EFO_0005852
Disease	forced expiratory volume, response to bronchodilator	RICTOR LRRC4C MEIS2 INSL3	2.51e-03	445	38	4	EFO_0004314, GO_0097366
Disease	Intellectual Disability	CACNA1B KMT2E MEIS2 BRD4	2.55e-03	447	38	4	C3714756
Disease	risk-taking behaviour	NEO1 HIVEP1 LRRC4C KMT2E BARHL2	2.84e-03	764	38	5	EFO_0008579
Disease	pulse pressure measurement, alcohol drinking	FES LRRC4C	3.69e-03	70	38	2	EFO_0004329, EFO_0005763
Disease	osteoporosis	LRRC4C UBAP2	4.01e-03	73	38	2	EFO_0003882
Disease	C-reactive protein measurement	OR2W5P ZSWIM8 RICTOR NEO1 RERE MAP4K4	4.14e-03	1206	38	6	EFO_0004458
Disease	age of onset of asthma	RERE UBAP2L	4.67e-03	79	38	2	OBA_2001001
Disease	electrocardiography	OBSCN PCNX1 HIVEP1 SLC4A3	4.68e-03	530	38	4	EFO_0004327
Disease	chronotype measurement	HIVEP1 RERE NFATC3 MEIS2 BARHL2	5.23e-03	882	38	5	EFO_0008328

Protein segments in the cluster

Peptide	Gene	Start	Entry
QQHPPTHTLQPHHHI	AMELX	71	Q99217
QSSHHIHHPLSTHLP	SLC4A2	76	P04920
HTSHHTHHPLSARLP	SLC4A3	76	P48751
PQQVIQHHHSPRHHK	BRD4	1036	O60885
RQHHHLLQSPVSHHE	ARFGEF1	226	Q9Y6D6
RPPPSQASSHHHHHR	CACNA1B	2041	Q00975
HQQDPHHVHRNTPLH	DMXL1	336	Q9Y485
SHLSQQHHHLPQHLH	RBM27	696	Q9P2N5
LLSLQHDHRRPHPQH	MAP4K4	521	O95819
HRHVLHLPTVFHHLP	MGAT4B	106	Q9UQ53
VHHLNHGPPLHATQH	MEIS2	36	O14770
NLPSHNHHHHVDQSL	PCNX1	241	Q96RV3
HLHHHLPAQLALPHP	PDX1	81	P52945
SLLHHRHSQHQPPHL	OR2W5P	276	A6NFC9
HHTTSAQALHHPPHQ	KMT2E	1731	Q8IZD2
ESPSRHHHHLLHQLV	LRATD1	66	Q96KN4
LFTPLHHLERIHLHH	LRRC4C	286	Q9HCJ2
TILPHSHSHHLHCLP	RICTOR	436	Q6R327
QSHHLQHLERCPHVP	OBSCN	5716	Q5VST9
QHPSPHQHIQHHPNH	FOXJ3	416	Q9UPW0
HHPNHQHQTLTHQAP	FOXJ3	426	Q9UPW0
ATQHHHHLHHSQQPP	BARHL2	81	Q9NY43
LQPLPQTSHHHRHHR	INSL3	91	P51460
THHHPPLHRSAQDLR	JARID2	286	Q92833
HHQHHHQLLLPGLLR	FES	196	P07332
SAHPIHSLDNPHHHF	NEO1	1251	Q92859
HHPHPQHVTHIQDLT	TBATA	81	Q96M53
HIHSHLHLHQQDPLH	RERE	1431	Q9P2R6
PEHQHHSLRDLPVHN	STARD9	4126	Q9P2P6
HILPAHQQPHSQLLH	UBAP2	1066	Q5T6F2
HQQPHSQLLHHHLPQ	UBAP2	1071	Q5T6F2
HSSHLPIAHLHPLSQ	ZNF804B	1226	A4D1E1
LTPHQQPHSQILHHH	UBAP2L	1036	Q14157
LHLIPHALEPHSHHT	SLC39A7	186	Q92504
LAHTPHSVHTLPHLQ	NFATC3	866	Q12968
PHKQSVPHLALHAQH	ZC3H12B	651	Q5HYM0
THSQPVNPHSLHHLH	ZSWIM8	1651	A7E2V4
VPHICPHRHHLHTVQ	RELT	271	Q969Z4
PHTHLFSHLPLHSQQ	HIVEP1	2376	P15822
TQHIHLKLHHRLHAP	ZNF683	436	Q8IZ20