Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	dense core granule	FZD8 DMXL2 VPS13C SLC6A5	7.25e-05	56	83	4	GO:0031045
GeneOntologyCellularComponent	katanin complex	KATNAL1 KATNA1	1.55e-04	5	83	2	GO:0008352
GeneOntologyCellularComponent	somatodendritic compartment	GDPD5 RELN ANK3 KCNB1 DSCAM FZD5 PCLO FRMD7 NUMB APOB KATNA1 KCNB2 ADCY9 SYNGAP1	3.17e-04	1228	83	14	GO:0036477
Domain	K_chnl_volt-dep_Kv2	KCNB1 KCNB2	1.95e-05	2	83	2	IPR003973
Domain	KATNA1	KATNAL1 KATNA1	1.95e-05	2	83	2	IPR028596
Domain	Kv2channel	KCNB1 KCNB2	1.95e-05	2	83	2	PF03521
Domain	SYCP1/2	SYCP2 SYCP1	5.84e-05	3	83	2	IPR024835
Domain	Vps4_C	KATNAL1 KATNA1	5.37e-04	8	83	2	PF09336
Domain	Vps4_C	KATNAL1 KATNA1	5.37e-04	8	83	2	IPR015415
Domain	Frizzled	FZD8 FZD5	1.05e-03	11	83	2	IPR000539
Domain	Frizzled	FZD8 FZD5	1.05e-03	11	83	2	PF01534
Domain	Frizzled	FZD8 FZD5	1.05e-03	11	83	2	SM01330
Domain	Frizzled/SFRP	FZD8 FZD5	2.25e-03	16	83	2	IPR015526
Domain	Integrin_alpha-2	ITGA11 ITGAE	2.85e-03	18	83	2	IPR013649
Domain	Integrin_alpha2	ITGA11 ITGAE	2.85e-03	18	83	2	PF08441
Domain	Integrin_alpha	ITGA11 ITGAE	2.85e-03	18	83	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA11 ITGAE	2.85e-03	18	83	2	PS00242
Domain	Int_alpha_beta-p	ITGA11 ITGAE	3.18e-03	19	83	2	IPR013519
Domain	GUANYLATE_CYCLASE_1	GUCY1B2 ADCY9	3.18e-03	19	83	2	PS00452
Domain	Guanylate_cyc	GUCY1B2 ADCY9	3.18e-03	19	83	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY1B2 ADCY9	3.18e-03	19	83	2	PS50125
Domain	A/G_cyclase	GUCY1B2 ADCY9	3.18e-03	19	83	2	IPR001054
Domain	Int_alpha	ITGA11 ITGAE	3.18e-03	19	83	2	SM00191
Domain	CYCc	GUCY1B2 ADCY9	3.18e-03	19	83	2	SM00044
Domain	FRI	FZD8 FZD5	3.52e-03	20	83	2	SM00063
Domain	-	FZD8 FZD5	3.88e-03	21	83	2	1.10.2000.10
Domain	FG_GAP	ITGA11 ITGAE	4.25e-03	22	83	2	PS51470
Domain	FG-GAP	ITGA11 ITGAE	5.05e-03	24	83	2	PF01839
Domain	Frizzled_dom	FZD8 FZD5	5.05e-03	24	83	2	IPR020067
Domain	FG-GAP	ITGA11 ITGAE	5.05e-03	24	83	2	IPR013517
Domain	FZ	FZD8 FZD5	5.05e-03	24	83	2	PS50038
Domain	Fz	FZD8 FZD5	5.05e-03	24	83	2	PF01392
Domain	Integrin_dom	ITGA11 ITGAE	5.48e-03	25	83	2	IPR032695
Domain	K_chnl_volt-dep_Kv	KCNB1 KCNB2	6.37e-03	27	83	2	IPR003968
Domain	WD40_repeat	DMXL2 WDR87 LRBA HERC2 MAPKBP1	7.28e-03	272	83	5	IPR001680
Domain	ATPase_AAA_CS	KATNAL1 KATNA1	7.33e-03	29	83	2	IPR003960
Domain	WD_REPEATS_1	DMXL2 WDR87 LRBA HERC2 MAPKBP1	7.97e-03	278	83	5	PS00678
Domain	WD_REPEATS_2	DMXL2 WDR87 LRBA HERC2 MAPKBP1	8.08e-03	279	83	5	PS50082
Domain	WD_REPEATS_REGION	DMXL2 WDR87 LRBA HERC2 MAPKBP1	8.08e-03	279	83	5	PS50294
Domain	BTB	ZBTB49 KCNB1 BACH2 KCNB2	8.49e-03	180	83	4	SM00225
Pubmed	Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.	KCNB1 KCNB2	6.04e-06	2	86	2	28607108
Pubmed	PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer.	PDCD1 ITGAE	6.04e-06	2	86	2	25957117
Pubmed	Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.	KCNB1 KCNB2	6.04e-06	2	86	2	29403353
Pubmed	KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons.	KATNAL1 KATNA1	6.04e-06	2	86	2	30448058
Pubmed	Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.	KCNB1 KCNB2	6.04e-06	2	86	2	30091655
Pubmed	The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.	KATNAL1 KATNA1	6.04e-06	2	86	2	37882691
Pubmed	Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.	KCNB1 KCNB2	6.04e-06	2	86	2	26538660
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 ANK3 GNA13 AHNAK PCLO KCNB2 SYNGAP1	6.50e-06	281	86	7	28706196
Pubmed	Genetically distinct subsets within ANCA-associated vasculitis.	FZD8 MXRA5 KATNAL1	1.16e-05	18	86	3	22808956
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	BACH2 HERC2 TG	1.37e-05	19	86	3	22561518
Pubmed	The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.	KCNB1 KCNB2	1.81e-05	3	86	2	23161216
Pubmed	Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.	KCNB1 KCNB2	1.81e-05	3	86	2	8670833
Pubmed	Age-related accumulation of Reelin in amyloid-like deposits.	RELN SYNGAP1	1.81e-05	3	86	2	17904250
Pubmed	Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.	FZD8 FZD5	1.81e-05	3	86	2	11520064
Pubmed	Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle.	KCNB1 KCNB2	1.81e-05	3	86	2	22422395
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EPS15 ANK3 DSCAM VPS13C AHNAK APOB LRBA NCAPH ADCY9 TASOR2	2.24e-05	777	86	10	35844135
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	ANK3 PCLO SV2C APOB TG SYNGAP1	2.55e-05	233	86	6	29518331
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	LINS1 SYCP2 ANK3 ZFHX4 PKD1L2 KATNA1 SLC13A2	3.26e-05	361	86	7	26167880
Pubmed	A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal.	RELN SBNO2	3.61e-05	4	86	2	17045962
Pubmed	Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.	SYCP2 SYCP1	3.61e-05	4	86	2	22011390
Pubmed	Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.	KCNB1 KCNB2	3.61e-05	4	86	2	30012696
Pubmed	Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis.	EPS15 NUMB	3.61e-05	4	86	2	10953014
Pubmed	Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans.	KCNB1 KCNB2	3.61e-05	4	86	2	38335058
Pubmed	Kv2 channel-AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking.	KCNB1 KCNB2	6.01e-05	5	86	2	34137443
Pubmed	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	KCNB1 KCNB2	6.01e-05	5	86	2	19074135
Pubmed	A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.	FZD8 FZD5	6.01e-05	5	86	2	26908622
Pubmed	Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.	ANK3 TET1	6.01e-05	5	86	2	18163421
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNB1 KCNB2	6.01e-05	5	86	2	2333511
Pubmed	Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution.	SYCP2 SYCP1	6.01e-05	5	86	2	25646409
Pubmed	Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity.	APOB CUBN	6.01e-05	5	86	2	36936697
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	KCNB1 KCNB2	6.01e-05	5	86	2	31663850
Pubmed	Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.	KATNAL1 KATNA1	6.01e-05	5	86	2	26929214
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	FZD8 FZD5	6.01e-05	5	86	2	11029007
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	SYCP2 TET1 SYCP1	6.87e-05	32	86	3	27739607
Pubmed	Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.	KATNAL1 KATNA1	9.01e-05	6	86	2	28436967
Pubmed	DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.	RELN TET1	9.01e-05	6	86	2	25476119
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	EPS15 GUCY1B2 ANK3 CYP26C1 NUMB TASOR2 SYNGAP1	9.76e-05	430	86	7	35044719
Pubmed	Personal receptor repertoires: olfaction as a model.	OR5H6 OR1P1 OR5D13	1.16e-04	38	86	3	22908908
Pubmed	Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.	EPS15 NUMB	1.26e-04	7	86	2	27940916
Pubmed	SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division.	SYCP2 SYCP1	1.26e-04	7	86	2	15870106
Pubmed	Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.	KCNB1 KCNB2	1.26e-04	7	86	2	34312846
Pubmed	Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.	FZD8 FZD5	1.26e-04	7	86	2	9192640
Pubmed	MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.	FZD8 FZD5	1.26e-04	7	86	2	15195140
Pubmed	Disruption of CHTF18 causes defective meiotic recombination in male mice.	SYCP2 SYCP1	1.26e-04	7	86	2	23133398
Pubmed	Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.	FZD8 FZD5	1.26e-04	7	86	2	11335128
Pubmed	Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.	FZD8 FZD5	1.26e-04	7	86	2	11265645
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD8 FZD5	1.26e-04	7	86	2	15370539
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	LTN1 HERC2	1.26e-04	7	86	2	36700049
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD8 FZD5	1.68e-04	8	86	2	10559494
Pubmed	Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.	SYCP2 SYCP1	1.68e-04	8	86	2	25634095
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	RSBN1 DCHS2 ACAD8 FMOD KCNB1 DSCAM BACH2 SLC6A5 SCRN1	1.86e-04	814	86	9	23251661
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	RELN KCNB1 ADCY9	1.92e-04	45	86	3	25979088
Pubmed	BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.	SYCP2 SYCP1	2.15e-04	9	86	2	19531582
Pubmed	Galpha12/Galpha13 deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices.	RELN GNA13	2.15e-04	9	86	2	18086886
Pubmed	Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.	EPS15 NUMB	2.15e-04	9	86	2	9303539
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	FZD8 FZD5 APOB	2.48e-04	49	86	3	19562671
Pubmed	Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.	FZD8 FZD5 NUMB	2.63e-04	50	86	3	27510977
Pubmed	Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.	SYCP2 SYCP1	2.68e-04	10	86	2	18283110
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD8 FZD5	2.68e-04	10	86	2	15245425
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	RELN ADCY9	2.68e-04	10	86	2	16615126
Pubmed	Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.	RELN MLLT3	2.68e-04	10	86	2	19000783
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD8 FZD5	2.68e-04	10	86	2	17532316
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD8 FZD5	3.28e-04	11	86	2	24860427
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	ANK3 PCLO	3.28e-04	11	86	2	20351715
Pubmed	ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.	FZD8 FZD5	3.28e-04	11	86	2	22575959
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD8 FZD5	3.28e-04	11	86	2	30978219
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD8 FZD5	3.28e-04	11	86	2	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD8 FZD5	3.28e-04	11	86	2	17576136
Pubmed	FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.	KCNB1 KCNB2	3.28e-04	11	86	2	33124732
Pubmed	Multiple roles of integrin-α3 at the neuromuscular junction.	PCLO SV2C	3.93e-04	12	86	2	28386022
Pubmed	Meiotic cohesin complexes are essential for the formation of the axial element in mice.	SYCP2 SYCP1	3.93e-04	12	86	2	22711701
Pubmed	A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.	SYCP2 SYCP1	3.93e-04	12	86	2	21274006
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ANK3 AHNAK TET1 NUMB LRBA CHORDC1 NCAPH	4.31e-04	549	86	7	38280479
Pubmed	Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.	RELN TG	4.63e-04	13	86	2	22724066
Pubmed	Meiotic failure in male mice lacking an X-linked factor.	SYCP2 SYCP1	4.63e-04	13	86	2	18316482
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	FZD8 FZD5	4.63e-04	13	86	2	22266179
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	PCLO SV2C	5.39e-04	14	86	2	21228161
Pubmed	Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.	RELN NUMB	5.39e-04	14	86	2	14687546
Pubmed	Tet1 controls meiosis by regulating meiotic gene expression.	TET1 SYCP1	5.39e-04	14	86	2	23151479
Pubmed	Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.	SYCP2 SYCP1	5.39e-04	14	86	2	22346761
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	RELN NUMB	5.39e-04	14	86	2	15273690
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EPS15 ZFHX4 AHNAK TET1 BCORL1 LRBA	6.08e-04	418	86	6	34709266
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	HERC2 SBNO2	7.09e-04	16	86	2	19068216
Pubmed	Sex-specific chromatin remodelling safeguards transcription in germ cells.	TET1 SYCP1	7.09e-04	16	86	2	34880491
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD8 FZD5	8.02e-04	17	86	2	28733458
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TCHHL1 GNA13 AHNAK PCLO SYCP1 ATP10B APOB ALAS2 NCAPH TASOR2 AAR2	8.46e-04	1442	86	11	35575683
Pubmed	Genome-wide association of mood-incongruent psychotic bipolar disorder.	NUMB LRBA	9.01e-04	18	86	2	23092984
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	ANK3 KCNB1	9.01e-04	18	86	2	37321992
Pubmed	Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.	RELN NUMB	9.01e-04	18	86	2	23817546
Pubmed	MORC2B is essential for meiotic progression and fertility.	SYCP2 SYCP1	9.01e-04	18	86	2	29329290
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	EPS15 NUMB	9.01e-04	18	86	2	23211419
Pubmed	Gestational folate deficiency alters embryonic gene expression and cell function.	APOB CUBN	9.01e-04	18	86	2	33302058
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	ACAD8 ANK3 SYCP1 HRG LRBA	9.65e-04	304	86	5	32235678
Pubmed	SKP1 drives the prophase I to metaphase I transition during male meiosis.	SYCP2 SYCP1	1.01e-03	19	86	2	32232159
Pubmed	Gli3 is required for the specification and differentiation of preplate neurons.	RELN NUMB	1.01e-03	19	86	2	16168404
Pubmed	Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.	FZD8 FZD5	1.01e-03	19	86	2	20890044
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD8 FZD5	1.01e-03	19	86	2	21623369
Pubmed	STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.	SYCP2 SYCP1	1.12e-03	20	86	2	24797475
Pubmed	Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing.	FOSB FRMD7	1.12e-03	20	86	2	31291246
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 DMXL2 RELN ACAD8 ANK3 DSCAM MLLT3 LRBA HERC2 SYNGAP1	1.27e-03	1285	86	10	35914814
Cytoband	10q21	ANK3 TET1	4.09e-04	16	86	2	10q21
Cytoband	10p15.1	TUBAL3 TASOR2	1.27e-03	28	86	2	10p15.1
Cytoband	2q33.3	CCNYL1 FZD5	1.46e-03	30	86	2	2q33.3
Cytoband	4q31.3	DCHS2 LRBA	1.56e-03	31	86	2	4q31.3
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD8 FZD5	6.44e-04	11	63	2	286
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA11 ITGAE	1.76e-03	18	63	2	1160
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SYCP2 ZFHX4 SLC24A2 PCLO APOB PKD1L2	6.98e-08	184	86	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SYCP2 ZFHX4 SLC24A2 PCLO APOB PKD1L2	6.98e-08	184	86	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SYCP2 ZFHX4 SLC24A2 PCLO APOB PKD1L2	6.98e-08	184	86	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 GPR22 SYCP1 ATP10B CUBN KCNB2	6.84e-07	160	86	6	f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ITGA11 MXRA5 FMOD AHNAK ATL3 SCRN1	2.23e-06	196	86	6	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Scn4b_(Globus_Pallidus_Externus_(GP),_"Prototypical")--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCHHL1 SLC6A5 PKD1L2 ITGAE	2.90e-06	51	86	4	74d7932d0e7363c00117890747980b4b04ff4524
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Scn4b_(Globus_Pallidus_Externus_(GP),_"Prototypical")-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCHHL1 SLC6A5 PKD1L2 ITGAE	2.90e-06	51	86	4	88597bef58fe807b65da34925e863e7fbe3a7e3e
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Scn4b_(Globus_Pallidus_Externus_(GP),_"Prototypical")\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCHHL1 SLC6A5 PKD1L2 ITGAE	2.90e-06	51	86	4	91e17b1a85e2b5c507c64f39f322a5a9b7bf30bd
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSCAM SV2C ALAS2 KCNB2 SLC52A3	1.57e-05	162	86	5	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA11 DSCAM OPN3 NCAPH TG	2.09e-05	172	86	5	b043d4f81dced7fb3326043f68474123be47cc5d
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KCNB1 SLC24A2 FOSB PCLO	3.20e-05	188	86	5	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CFuPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	GDPD5 GPR22 ANK3 SLC24A2 BACH2	3.81e-05	195	86	5	574354ef4bcefeb9856b65d19bb92e2cffe5dc7a
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KCNB1 SLC24A2 VPS13C PCLO	3.81e-05	195	86	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KCNB1 SLC24A2 VPS13C PCLO	3.81e-05	195	86	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	FZD8 ZFHX4 FOSB AHNAK SCRN1	4.00e-05	197	86	5	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	FZD8 ZFHX4 FOSB AHNAK SCRN1	4.00e-05	197	86	5	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	moderate-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLF1 VPS13C FOSB AHNAK ITGAE	4.09e-05	198	86	5	0a868098b1ee4b28b2149ed766acb09e9c0ce14c
ToppCell	Neuron\|World / Primary Cells by Cluster	GPR22 ANK3 BACH2 PCLO MLLT3	4.19e-05	199	86	5	1f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCell	Neuron-Postmitotic\|World / Primary Cells by Cluster	GPR22 ANK3 BACH2 PCLO MLLT3	4.19e-05	199	86	5	1973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	GPR22 ANK3 BACH2 PCLO MLLT3	4.19e-05	199	86	5	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FZD8 ITGA11 FMOD ZFHX4 FOSB	4.29e-05	200	86	5	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SLF1 ANK3 KCNB1 PCLO KCNB2	4.29e-05	200	86	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	RSBN1 ANK3 ZFHX4 KCNB1 SCRN1	4.29e-05	200	86	5	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Biopsy_Control_(H.)-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	MXRA5 FMOD ZFHX4 INSYN1 TET1	4.29e-05	200	86	5	cdaf462b1db29dab61038eeab5ddd3eef3386763
Disease	interleukin-2 receptor subunit alpha measurement	SLC6A5 TUBAL3 TASOR2	2.96e-05	21	85	3	EFO_0010587
Disease	mastiha supplement exposure measurement, blood glutathione peroxidase measurement	SLC24A2 MLLT3	8.15e-05	5	85	2	EFO_0600067, EFO_0600071
Disease	non-melanoma skin carcinoma	RSBN1 ZFHX4 BACH2 HERC2 SBNO2 AAR2	1.20e-04	265	85	6	EFO_0009260
Disease	verbal memory measurement	SLC24A2 MLLT3	1.71e-04	7	85	2	EFO_0009591
Disease	C-reactive protein measurement	DCHS2 DMXL2 ANK3 VPS13C AHNAK CYP26C1 NUMB APOB KATNA1 KCNB2 ADCY9 OR5D13	1.72e-04	1206	85	12	EFO_0004458
Disease	attempted suicide, mood disorder	SLC24A2 MLLT3	2.27e-04	8	85	2	EFO_0004247, EFO_0004321
Disease	age at onset, multiple sclerosis	RELN KCNB2	3.64e-04	10	85	2	EFO_0004847, MONDO_0005301
Disease	keratinocyte carcinoma	RSBN1 BACH2 HERC2 SBNO2	3.83e-04	118	85	4	EFO_0010176
Disease	pro‐interleukin‐16 measurement	SLC24A2 MLLT3	4.44e-04	11	85	2	EFO_0010629
Disease	mood disorder	RELN SV2C	6.27e-04	13	85	2	EFO_0004247
Disease	S-6-hydroxywarfarin measurement	VPS13C PCLO MLLT3 KATNAL1 KCNB2 ITGAE	6.90e-04	368	85	6	EFO_0803326
Disease	bipolar I disorder	ANK3 KCNB1 RBPJL CUBN	7.49e-04	141	85	4	EFO_0009963
Disease	skin sensitivity to sun	KATNAL1 HERC2	1.36e-03	19	85	2	EFO_0004795
Disease	late-onset Alzheimers disease	ANK3 SLC24A2 AHNAK MLLT3 SYNGAP1	1.58e-03	292	85	5	EFO_1001870
Disease	coronary artery calcification	ZBTB49 DMXL2 RBM44 ANK3 NUMB APOB	1.93e-03	450	85	6	EFO_0004723
Disease	basal cell carcinoma	RSBN1 BACH2 HERC2 SBNO2	2.20e-03	189	85	4	EFO_0004193
Disease	nose morphology measurement	DCHS2 SLC24A2 MLLT3 NCAPH TASOR2	2.65e-03	329	85	5	EFO_0007843

Protein segments in the cluster

Peptide	Gene	Start	Entry
IESHTFATSTLTQFC	ABCG4	361	Q9H172
VIFSSSACDQVSTSV	BACH2	431	Q9BYV9
SVIFEALATGCTSTT	ACAD8	106	Q9UKU7
TTFDFDLCSLDKTTV	MLLT3	541	P42568
STLQVFFSSACSIAV	AAR2	326	Q9Y312
FCVSSSFSKVELTAV	BCORL1	51	Q5H9F3
TREVFSSCSSEVVLS	AHNAK	101	Q09666
SDFAFITSSSLVATS	DMXL2	2856	Q8TDJ6
SSCSTIFLDDSTVSQ	CCNYL1	121	Q8N7R7
TTSSIADFFLALTIC	ATP10B	576	O94823
ISTTFGCTSSSDTEI	IL13RA2	16	Q14627
SVEFSFSTSLACTLE	RBPJL	366	Q9UBG7
QTVDVSTDFRACFTT	RBM44	466	Q6ZP01
EFCSFLDVSTPSDSV	INSYN1	111	Q2T9L4
SSLESSAVISAFFEC	LTN1	401	O94822
ACDLSAFFDSTTLDT	LTN1	1281	O94822
SISVASFQELSACVF	MLX	256	Q9UH92
VSAFTLSFCGTSEID	OR9Q1	161	Q8NGQ5
NEFSISSFCTVVDVV	FMOD	326	Q06828
VIDFNCTTSSVSSAL	HRG	121	P04196
STVLLDFLISSETCF	LINS1	506	Q8NG48
FETVCFASILSITTV	NMUR2	126	Q9GZQ4
FDFLGSLLTTCSSDV	HERC2	2101	O95714
IFSERSSLSSFQTSC	FRMD7	436	Q6ZUT3
CFEISSVTTASESGL	ITGAE	706	P38570
ATETVTFVTCTASAS	PCLO	2791	Q9Y6V0
TFTCSFSNTSESFVL	PDCD1	51	Q15116
LALSCSDTFTSEVVT	OR5A2	186	Q8NGI9
TSDTFDKCFLGSSET	LRBA	336	P50851
AERTSSQVTILCTFF	GDPD5	186	Q8WTR4
DCSAYTLSFDTTVFI	ITGA11	816	Q9UKX5
CFDSVTSILFLVSSS	GNA13	236	Q14344
SSCFVANDSTLFTLA	ALAS2	256	P22557
SFLQIDFAASCSVTD	RELN	2376	P78509
TVLTSFAIFCNASTA	PKD1L2	786	Q7Z442
SCTVFVNVSFSSEGT	DCHS2	2971	Q6V1P9
QFFSLVTTVTTECFL	OR5H6	116	Q8NGV6
TSSFVLTCPEVSAFA	FOSB	301	P53539
FNSSSIIFIITSDES	OPN3	366	Q9H1Y3
TLSFTHFELERSTTC	CUBN	1661	O60494
CFISTSTTVATFLID	FZD5	246	Q13467
VLCFVSTFATVSTFL	FZD8	286	Q9H461
TVLDSTCSSTVQFLE	APOB	3911	P04114
SSIDSFISCATDFPE	KCNB1	586	Q14721
SSIDSFTSCATDFTE	KCNB2	601	Q92953
FTSCATDFTETERSP	KCNB2	606	Q92953
DAVFAACTSTILSFT	GPR148	126	Q8TDV2
VFLSTTVFLTLSTTC	ADCY9	791	O60503
SITECSIATTAEFSH	ANK3	3391	Q12955
AAFFTTASASTSLVL	CYP26C1	296	Q6V0L0
AFDSQSTVKDCATIF	ATL3	146	Q6DD88
VSSRVTAVSFSEDCS	MAPKBP1	176	O60336
AVATECKTTFFNVSS	KATNA1	261	O75449
FTLTISCLQSEDFAT	IGKV1-8	91	A0A0C4DH67
EIFCDPFTSATTTTN	EPS15	821	P42566
CVSFASVSTAINVFA	GPR22	121	Q99680
LVATFTECTSNVATT	SLC13A2	466	Q13183
SHLSLTDFCFSTVVT	OR5D13	66	Q8NGL4
FLASLSCADIFSTST	OR1P1	76	Q8NH06
CGVTATFDASRTTFT	NUMB	176	P49757
KFTITECFISDTSSE	DSCAM	1831	O60469
ACTEIQLLTTASSSF	RSBN1	746	Q5VWQ0
VATECGTTFFNVSSS	KATNAL1	261	Q9BW62
LTFFLALVDCTSSVT	SLC52A3	111	Q9NQ40
VFKSCTFEDVTSVNT	SV2C	516	Q496J9
DTLIVTCTNSATSIF	SLC6A5	501	Q9Y345
TVSFSISAFSETDTQ	SLC24A2	51	Q9UI40
TILFSDVVTFTNICT	GUCY1B2	391	O75343
FSNISIFSSSVDSLS	SBNO2	101	Q9Y2G9
EQFSVSDITTACFES	TUBAL3	291	A6NHL2
CIDSEFFLTTASGVS	SCRN1	266	Q12765
VVSTKSEEEVCSSSF	TET1	1366	Q8NFU7
SFDECSTAGVFLSTL	NCAPH	251	Q15003
RTTDFSDFLSIVGCT	CHORDC1	46	Q9UHD1
TTEVCDDKFLFSLTS	ZFHX4	2811	Q86UP3
SSILGQEFCFEVTTS	SYNGAP1	211	Q96PV0
AAHSFVVTEFETTVC	SYCP1	371	Q15431
SVFCNTDSEETVFTS	SYCP2	1471	Q9BX26
FFPVCFSSDSTEVTT	VPS13C	2736	Q709C8
SSQELEIFICSFSSS	SLF1	661	Q9BQI6
TDTRTIFVAIFSCIS	VSTM1	131	Q6UX27
FAFSTSTDLTTVESQ	ZBTB49	241	Q6ZSB9
PLASFVSESFDTSVC	TASOR2	1771	Q5VWN6
SVSLTSEISDCSVFF	TCHHL1	836	Q5QJ38
EACSFFTVSTTEPEI	TG	1611	P01266
TSFDVCLSLSLFVTG	WDR87	571	Q6ZQQ6
CTLSRITTFDFSGVT	LRRC51	151	Q96E66
VDFTSEFLSSLTVST	MXRA5	1416	Q9NR99