Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coactivator activity	NCOA3 TSC22D1 KMT2D ATN1 ZMIZ2 SRCAP TRIM24 CREBBP	2.18e-05	303	77	8	GO:0003713
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SRRT NCOA3 NLRP12 TSC22D1 KMT2D ATN1 RBM33 ZNF366 ZMIZ2 SRCAP KLF4 WNK1 TRIM24 CREBBP SHANK3	3.11e-05	1160	77	15	GO:0030674
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXO3 FOXO3B NCOA3 POU6F2 GSX1 USF3 ZNF366 SKOR2 SREBF1 DMRTB1 ZFHX3 ZNF362 KLF4 TRIM24 CREBBP GLIS1 NPAS2	3.21e-05	1459	77	17	GO:0000977
GeneOntologyMolecularFunction	molecular adaptor activity	SRRT NCOA3 NLRP12 TSC22D1 KMT2D ATN1 RBM33 ZNF366 ZMIZ2 SRCAP KLF4 WNK1 TRIM24 CREBBP SHANK3	1.81e-04	1356	77	15	GO:0060090
GeneOntologyMolecularFunction	transcription coregulator binding	FOXO3 SREBF1 MED25 KLF4 CREBBP	2.08e-04	140	77	5	GO:0001221
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXO3 FOXO3B POU6F2 GSX1 ZNF366 SKOR2 SREBF1 DMRTB1 ZFHX3 ZNF362 KLF4 TRIM24 GLIS1 NPAS2	2.57e-04	1244	77	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXO3 FOXO3B FOXN1 NCOA3 POU6F2 GSX1 KMT2D USF3 SKOR2 SREBF1 DMRTB1 ZFHX3 KLF4 GLIS1 NPAS2	2.80e-04	1412	77	15	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXO3 FOXN1 NCOA3 GSX1 KMT2D USF3 SREBF1 KLF4 GLIS1	2.98e-04	560	77	9	GO:0001228
GeneOntologyMolecularFunction	transcription coregulator activity	NCOA3 TSC22D1 KMT2D ATN1 ZNF366 ZMIZ2 SRCAP TRIM24 CREBBP	3.06e-04	562	77	9	GO:0003712
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXO3 FOXO3B POU6F2 GSX1 ZNF366 SKOR2 SREBF1 DMRTB1 ZFHX3 ZNF362 KLF4 TRIM24 GLIS1 NPAS2	3.20e-04	1271	77	14	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXO3 FOXN1 NCOA3 GSX1 KMT2D USF3 SREBF1 KLF4 GLIS1	3.22e-04	566	77	9	GO:0001216
GeneOntologyMolecularFunction	transcription factor binding	FOXO3 NCOA3 ZNF366 ARID2 SREBF1 MED25 GRM1 KLF4 TRIM24 CREBBP	6.13e-04	753	77	10	GO:0008134
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA3 ZNF366 MED25 GRM1 TRIM24	7.82e-04	187	77	5	GO:0016922
GeneOntologyMolecularFunction	histone acetyltransferase activity	NCOA3 SRCAP CREBBP	1.01e-03	51	77	3	GO:0004402
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	NCOA3 ZNF366 GRM1	1.12e-03	53	77	3	GO:0030331
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NCOA3 ZNF366 MED25 GRM1 KLF4 TRIM24 CREBBP	1.13e-03	417	77	7	GO:0061629
GeneOntologyMolecularFunction	Hsp90 protein binding	CYP2B6 CYP2E1 NPAS2	1.25e-03	55	77	3	GO:0051879
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	NCOA3 SRCAP CREBBP	1.25e-03	55	77	3	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	NCOA3 SRCAP CREBBP	1.61e-03	60	77	3	GO:0034212
GeneOntologyMolecularFunction	chromatin binding	FOXO3 NCOA3 PYGO2 SKOR2 SREBF1 MLLT6 KLF4 TRIM24 CREBBP	2.11e-03	739	77	9	GO:0003682
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	NCOA3 SCAF8 CREBBP	2.12e-03	66	77	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	NCOA3 SCAF8 CREBBP	2.12e-03	66	77	3	GO:0001098
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOA3 CREBBP	2.94e-03	21	77	2	GO:0042975
GeneOntologyMolecularFunction	N-acetyltransferase activity	NCOA3 SRCAP CREBBP	3.41e-03	78	77	3	GO:0008080
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2B6 CYP2E1	3.83e-03	24	77	2	GO:0008392
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXO3 FOXN1 NCOA3 TSC22D1 GSX1 KMT2D USF3 ARID2 MED28 ZMIZ2 SREBF1 MED25 MLLT6 ZFHX3 SSBP2 KLF4 CREBBP GLIS1 NPAS2	5.77e-07	1390	77	19	GO:0045944
GeneOntologyCellularComponent	transcription regulator complex	FOXO3 NCOA3 PYGO2 ARID2 MED28 SKOR2 MED25 ZFHX3 KLF4 CREBBP NPAS2	1.12e-05	596	77	11	GO:0005667
GeneOntologyCellularComponent	chromatin	FOXO3 FOXN1 NCOA3 POU6F2 GSX1 ARID2 ZMIZ2 SREBF1 DMRTB1 ZFHX3 SRCAP KLF4 TRIM24 CREBBP NPAS2	2.85e-04	1480	77	15	GO:0000785
GeneOntologyCellularComponent	RNA polymerase II transcription regulator complex	NCOA3 PYGO2 MED28 MED25 CREBBP NPAS2	5.03e-04	272	77	6	GO:0090575
GeneOntologyCellularComponent	ribonucleoprotein granule	ATXN2L UBAP2 INA FASTK NYNRIN ANKRD34C	6.66e-04	287	77	6	GO:0035770
GeneOntologyCellularComponent	ESCRT I complex	UBAP1L VPS37B	8.63e-04	12	77	2	GO:0000813
HumanPheno	Short 5th finger	KMT2D ARID2 GNAS SRCAP RAI1	1.17e-05	64	25	5	HP:0009237
HumanPheno	Aplasia/Hypoplasia of the 5th finger	KMT2D ARID2 GNAS SRCAP RAI1	1.36e-05	66	25	5	HP:0006262
HumanPheno	Persistent left superior vena cava	ATN1 MED25 SRCAP CREBBP RAI1	4.18e-05	83	25	5	HP:0005301
HumanPheno	Abnormal superior vena cava morphology	ATN1 MED25 SRCAP CREBBP RAI1	4.70e-05	85	25	5	HP:0025575
HumanPheno	Abnormal vena cava morphology	ATN1 MED25 SRCAP CREBBP RAI1	5.55e-05	88	25	5	HP:0030971
HumanPheno	Abnormal vena cava morphology	ATN1 MED25 SRCAP CREBBP RAI1	5.86e-05	89	25	5	HP:0005345
HumanPheno	Gastroesophageal reflux	KMT2D ATN1 ARID2 MED25 GNAS SRCAP WNK1 CREBBP SHANK3 RAI1	8.48e-05	517	25	10	HP:0002020
HumanPheno	Abnormality of dental eruption	SH3PXD2B KMT2D ARID2 GNAS SRCAP CREBBP RAI1	1.09e-04	240	25	7	HP:0006292
HumanPheno	Low hanging columella	KMT2D ATN1 SRCAP CREBBP	1.40e-04	56	25	4	HP:0009765
Domain	PHD	KMT2D PYGO2 MLLT6 TRIM24 RAI1	3.31e-05	89	77	5	SM00249
Domain	Znf_PHD	KMT2D PYGO2 MLLT6 TRIM24 RAI1	3.68e-05	91	77	5	IPR001965
Domain	ZF_PHD_2	KMT2D PYGO2 MLLT6 TRIM24 RAI1	4.53e-05	95	77	5	PS50016
Domain	ZF_PHD_1	KMT2D PYGO2 MLLT6 TRIM24 RAI1	4.76e-05	96	77	5	PS01359
Domain	EPHD	KMT2D MLLT6 RAI1	9.81e-05	22	77	3	PS51805
Domain	Nuc_rcpt_coact	NCOA3 CREBBP	2.49e-04	6	77	2	IPR009110
Domain	PHD	KMT2D PYGO2 MLLT6 TRIM24	2.60e-04	75	77	4	PF00628
Domain	PAS	NCOA3 KCNH4 NPAS2	3.07e-04	32	77	3	SM00091
Domain	Znf_PHD-finger	KMT2D PYGO2 MLLT6 TRIM24	3.17e-04	79	77	4	IPR019787
Domain	PAS	NCOA3 KCNH4 NPAS2	3.68e-04	34	77	3	IPR000014
Domain	PAS	NCOA3 KCNH4 NPAS2	3.68e-04	34	77	3	PS50112
Domain	-	RNF32 KMT2D PYGO2 ZMIZ2 MLLT6 TRIM65 SYVN1 TRIM24	5.17e-04	449	77	8	3.30.40.10
Domain	PAM2	ATXN2L PAIP1	5.93e-04	9	77	2	PF07145
Domain	Ataxin-2_C	ATXN2L PAIP1	5.93e-04	9	77	2	IPR009818
Domain	Znf_RING/FYVE/PHD	RNF32 KMT2D PYGO2 ZMIZ2 MLLT6 TRIM65 SYVN1 TRIM24	5.97e-04	459	77	8	IPR013083
Domain	HLH	NCOA3 USF3 SREBF1 NPAS2	1.15e-03	111	77	4	PF00010
Domain	HLH	NCOA3 USF3 SREBF1 NPAS2	1.35e-03	116	77	4	SM00353
Domain	BHLH	NCOA3 USF3 SREBF1 NPAS2	1.39e-03	117	77	4	PS50888
Domain	bHLH_dom	NCOA3 USF3 SREBF1 NPAS2	1.44e-03	118	77	4	IPR011598
Domain	Zinc_finger_PHD-type_CS	PYGO2 MLLT6 TRIM24	2.45e-03	65	77	3	IPR019786
Domain	Znf_FYVE_PHD	KMT2D PYGO2 MLLT6 TRIM24	3.19e-03	147	77	4	IPR011011
Domain	PAS_fold_3	KCNH4 NPAS2	4.01e-03	23	77	2	IPR013655
Domain	PAS_3	KCNH4 NPAS2	4.01e-03	23	77	2	PF08447
Domain	PAS-assoc_C	KCNH4 NPAS2	4.37e-03	24	77	2	IPR000700
Domain	PAS	NCOA3 NPAS2	4.73e-03	25	77	2	PF00989
Domain	PAS_fold	NCOA3 NPAS2	4.73e-03	25	77	2	IPR013767
Domain	PAC	KCNH4 NPAS2	5.11e-03	26	77	2	IPR001610
Domain	Bromodomain_CS	TRIM24 CREBBP	5.11e-03	26	77	2	IPR018359
Domain	PAC	KCNH4 NPAS2	5.11e-03	26	77	2	SM00086
Domain	PAC	KCNH4 NPAS2	5.11e-03	26	77	2	PS50113
Domain	ZF_RING_1	RNF32 KMT2D TRIM65 SYVN1 TRIM24	7.03e-03	291	77	5	PS00518
Domain	ZF_RING_2	RNF32 KMT2D TRIM65 SYVN1 TRIM24	7.75e-03	298	77	5	PS50089
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	NCOA3 MED28 SREBF1 MED25 KLF4 CREBBP	6.86e-07	84	53	6	M1008
Pathway	REACTOME_ADIPOGENESIS	NCOA3 MED28 SREBF1 MED25 KLF4 CREBBP	3.35e-06	110	53	6	M48259
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	NCOA3 MED28 SREBF1 MED25 CREBBP NPAS2	5.04e-06	118	53	6	M27316
Pathway	WP_RUBINSTEINTAYBI_SYNDROME_1	NCOA3 CREBBP NPAS2	2.21e-05	15	53	3	M48323
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO3 SREBF1 KLF4 CREBBP	1.08e-04	66	53	4	M27938
Pathway	REACTOME_CIRCADIAN_CLOCK	SREBF1 CREBBP RAI1 NPAS2	1.36e-04	70	53	4	M938
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NRXN2 GRM1 SHANK3	2.30e-04	32	53	3	MM15326
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NCOA3 KMT2D PYGO2 ATN1 RBM33 SSBP2 ZNF362 KLF4 TRIM24 CREBBP RAI1	2.63e-11	268	79	11	33640491
Pubmed	Interaction network of human early embryonic transcription factors.	NCOA3 KMT2D PYGO2 ATN1 ARID2 ZMIZ2 ZFHX3 SSBP2 TRIM24 CREBBP RAI1	4.64e-10	351	79	11	38297188
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXO3 FOXN1 NCOA3 TSC22D1 POU6F2 GSX1 KMT2D USF3 SKOR2 SREBF1 DMRTB1 ZFHX3 KLF4 GLIS1 NPAS2	1.81e-09	908	79	15	19274049
Pubmed	Human transcription factor protein interaction networks.	SRRT NCOA3 KMT2D UBAP2 PYGO2 ATN1 RBM33 SCAF8 ARID2 ZMIZ2 MLLT6 ZFHX3 SSBP2 SRCAP KLF4 TRIM24 CREBBP	1.76e-08	1429	79	17	35140242
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	FOXO3 NCOA3 TSC22D1 ARID2 ZMIZ2 SREBF1 MLLT6 ZFHX3 SRCAP KLF4 TRIM24 GLIS1 NPAS2	3.36e-08	808	79	13	20412781
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	USF3 UBAP2 ATN1 ARID2 ZMIZ2 MLLT6 GRM1 WNK1 VPS37B PAIP1	5.07e-08	430	79	10	35044719
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATXN2L NCOA3 ATN1 RBM33 ZMIZ2 VPS37B CREBBP	5.90e-08	152	79	7	38360978
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOA3 KMT2D PYGO2 ATN1 RBM33 SCAF8 TRIM24 CREBBP PAIP1 RAI1	8.93e-08	457	79	10	32344865
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOXO3 SH3PXD2B KMT2D SARS2 IER5L ZMIZ2 ARHGAP44 SREBF1 MLLT6 SYVN1 SRCAP KLF4 WNK1 RAI1	1.79e-07	1105	79	14	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FOXO3 TSC22D1 POU6F2 USF3 SCAF8 ARHGAP44 ENAH IGSF9 ZFHX3 ZNF362 GNAS CREBBP GLIS1 RAI1 NPAS2	1.13e-06	1489	79	15	28611215
Pubmed	Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.	NCOA3 CREBBP NPAS2	2.45e-06	12	79	3	14645221
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L SH3PXD2B KMT2D UBAP2 ARID2 ENAH PTPN23 SRCAP CREBBP	4.40e-06	549	79	9	38280479
Pubmed	CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription.	SREBF1 CREBBP	5.09e-06	2	79	2	9651391
Pubmed	Quantifying Protection in Disordered Proteins Using Millisecond Hydrogen Exchange-Mass Spectrometry and Peptic Reference Peptides.	NCOA3 CREBBP	5.09e-06	2	79	2	28675294
Pubmed	Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.	FOXO3 FOXO3B	5.09e-06	2	79	2	22588664
Pubmed	Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.	SREBF1 CREBBP	5.09e-06	2	79	2	9765204
Pubmed	Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.	FOXO3 FOXO3B	5.09e-06	2	79	2	9852958
Pubmed	Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1.	SREBF1 KLF4	5.09e-06	2	79	2	37229823
Pubmed	Exogenous H2 S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.	SREBF1 SYVN1	5.09e-06	2	79	2	37899701
Pubmed	Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.	NCOA3 CREBBP	5.09e-06	2	79	2	21632823
Pubmed	Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction.	KLF4 CREBBP	5.09e-06	2	79	2	10666450
Pubmed	The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein.	PYGO2 CREBBP	5.09e-06	2	79	2	19555349
Pubmed	Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome.	SRCAP CREBBP	5.09e-06	2	79	2	22265015
Pubmed	Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.	CYP2B6 CYP2E1	5.09e-06	2	79	2	12490624
Pubmed	SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression.	NCOA3 KLF4	5.09e-06	2	79	2	30585268
Pubmed	A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.	KMT2D CREBBP	5.09e-06	2	79	2	27999180
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	NCOA3 RBM33 KLF4 TRIM24 CREBBP	6.16e-06	113	79	5	23403292
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ATXN2L NCOA3 KMT2D RBM33 ARID2 MED28 ZMIZ2 MLLT6 ZNF362 TRIM24 CREBBP RAI1	7.06e-06	1103	79	12	34189442
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATXN2L ATN1 NYNRIN SREBF1 TNS2 DMRTB1 MLLT6 SYVN1 WNK1	9.97e-06	608	79	9	16713569
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	SREBF1 MED25 CREBBP	1.06e-05	19	79	3	16799563
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SRRT NCOA3 KMT2D ARID2 ZFHX3 TRIM24	1.13e-05	220	79	6	35785414
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NCOA3 TRIM24 CREBBP	1.25e-05	20	79	3	11877444
Pubmed	A human MAP kinase interactome.	TSC22D1 USF3 RBM33 ARID2 PTPN23 COG5 WNK1 CREBBP	1.50e-05	486	79	8	20936779
Pubmed	A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.	FOXO3 FOXO3B	1.53e-05	3	79	2	29925039
Pubmed	Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.	KMT2D CREBBP	1.53e-05	3	79	2	34463256
Pubmed	Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.	ARHGAP44 SHANK3	1.53e-05	3	79	2	23739967
Pubmed	TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation.	FOXO3 CREBBP	1.53e-05	3	79	2	34101965
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D PYGO2	1.53e-05	3	79	2	26902498
Pubmed	Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.	FOXO3 CREBBP	1.53e-05	3	79	2	22474372
Pubmed	Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells.	FOXO3 NCOA3	1.53e-05	3	79	2	29301589
Pubmed	Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.	NCOA3 CREBBP	1.53e-05	3	79	2	11823864
Pubmed	Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.	SRCAP CREBBP	1.53e-05	3	79	2	10347196
Pubmed	KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.	KMT2D CREBBP	1.53e-05	3	79	2	36893259
Pubmed	Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells.	KLF4 CREBBP	1.53e-05	3	79	2	21539536
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	SREBF1 MED25 CREBBP	1.93e-05	23	79	3	10235267
Pubmed	Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.	NCOA3 CREBBP	3.05e-05	4	79	2	10551785
Pubmed	Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).	NCOA3 CREBBP	3.05e-05	4	79	2	16227615
Pubmed	Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.	NCOA3 CREBBP	3.05e-05	4	79	2	33589584
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2D CREBBP	3.05e-05	4	79	2	28398509
Pubmed	Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.	SRCAP CREBBP	3.05e-05	4	79	2	11581372
Pubmed	KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.	FOXN1 KMT2D	3.05e-05	4	79	2	36525973
Pubmed	Cytochrome p450 and glutathione transferase expression in human breast cancer.	CYP2B6 CYP2E1	3.05e-05	4	79	2	12738724
Pubmed	Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.	FOXN1 KMT2D	3.05e-05	4	79	2	16972005
Pubmed	Regulation of the BRCA1 gene by an SRC3/53BP1 complex.	NCOA3 CREBBP	3.05e-05	4	79	2	21914189
Pubmed	CBP/p300 interact with and function as transcriptional coactivators of BRCA1.	NCOA3 CREBBP	3.05e-05	4	79	2	10655477
Pubmed	Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.	KLF4 CREBBP	3.05e-05	4	79	2	21482710
Pubmed	SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.	SREBF1 CREBBP	3.05e-05	4	79	2	8918891
Pubmed	The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes.	AGXT CREBBP	3.05e-05	4	79	2	12169688
Pubmed	Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain.	NCOA3 TRIM24	3.05e-05	4	79	2	11851396
Pubmed	Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.	FOXO3 GJA4	3.05e-05	4	79	2	37197981
Pubmed	A transcriptional switch mediated by cofactor methylation.	NCOA3 CREBBP	3.05e-05	4	79	2	11701890
Pubmed	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.	TRIM24 CREBBP	3.05e-05	4	79	2	31554795
Pubmed	Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.	NRXN2 SHANK3	3.05e-05	4	79	2	33262327
Pubmed	Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1.	NCOA3 CREBBP	3.05e-05	4	79	2	15449938
Pubmed	Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.	FOXO3 FOXO3B	3.05e-05	4	79	2	9479491
Pubmed	Direct sequencing and comprehensive screening of genetic polymorphisms on CYP2 family genes (CYP2A6, CYP2B6, CYP2C8, and CYP2E1) in five ethnic populations.	CYP2B6 CYP2E1	3.05e-05	4	79	2	24988984
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA3 KMT2D ZNF362 TRIM24	3.95e-05	83	79	4	28794006
Pubmed	FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).	FOXO3 CREBBP	5.07e-05	5	79	2	15126506
Pubmed	Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment.	NCOA3 CREBBP	5.07e-05	5	79	2	14766010
Pubmed	Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance.	NCOA3 CREBBP	5.07e-05	5	79	2	22977234
Pubmed	CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1.	ATN1 CREBBP	5.07e-05	5	79	2	36209140
Pubmed	Transcription factor-specific requirements for coactivators and their acetyltransferase functions.	NCOA3 CREBBP	5.07e-05	5	79	2	9445475
Pubmed	FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c.	FOXO3 SREBF1	5.07e-05	5	79	2	22511764
Pubmed	Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone.	CYP2B6 CYP2E1	5.07e-05	5	79	2	8006463
Pubmed	Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.	NCOA3 CREBBP	5.07e-05	5	79	2	10224118
Pubmed	MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function.	FOXO3 CREBBP	5.07e-05	5	79	2	12192052
Pubmed	The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.	RNF32 RBM33	5.07e-05	5	79	2	27867070
Pubmed	Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.	KLF4 CREBBP	5.07e-05	5	79	2	17908689
Pubmed	Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.	TRIM24 CREBBP	5.07e-05	5	79	2	11931765
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ATXN2L RBM33 ARID2 MED25 GNAS SRCAP WNK1 CREBBP	5.79e-05	588	79	8	38580884
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	ATXN2L ARID2 SKOR2 NPAS2	6.44e-05	94	79	4	25201988
Pubmed	Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.	NCOA3 CREBBP	7.60e-05	6	79	2	11076796
Pubmed	Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins.	NCOA3 CREBBP	7.60e-05	6	79	2	10777539
Pubmed	Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene.	CYP2B6 CYP2E1	7.60e-05	6	79	2	16125881
Pubmed	Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.	KMT2D CREBBP	7.60e-05	6	79	2	38570506
Pubmed	A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.	TRIM24 CREBBP	7.60e-05	6	79	2	10610177
Pubmed	Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.	FOXO3 NCOA3	7.60e-05	6	79	2	20733005
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	FOXO3 UBAP2 PYGO2 ATN1 ARHGAP44 ENAH TNS2 MLLT6 TRIM65 WNK1	1.05e-04	1021	79	10	26760575
Pubmed	HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1.	CYP2B6 CYP2E1	1.06e-04	7	79	2	24113184
Pubmed	BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.	NCOA3 CREBBP	1.06e-04	7	79	2	16860316
Pubmed	The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.	NCOA3 CREBBP	1.06e-04	7	79	2	9192892
Pubmed	The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation.	NCOA3 CREBBP	1.06e-04	7	79	2	17043108
Pubmed	Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype.	ATN1 CREBBP	1.06e-04	7	79	2	16858508
Pubmed	Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps.	ASGR2 SYVN1	1.06e-04	7	79	2	21062743
Pubmed	Mapping the Shh long-range regulatory domain.	RNF32 RBM33	1.06e-04	7	79	2	25252942
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TSC22D1 USF3 TTBK1 ARID2 PTPN23 WNK1 SHANK3	1.33e-04	493	79	7	15368895
Pubmed	Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.	NCOA3 CREBBP	1.41e-04	8	79	2	11971985
Pubmed	A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.	NCOA3 CREBBP	1.41e-04	8	79	2	8616895
Pubmed	Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.	NCOA3 CREBBP	1.41e-04	8	79	2	17475621
Pubmed	Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.	CYP2B6 CYP2E1	1.41e-04	8	79	2	18356043
Interaction	CRX interactions	NCOA3 KMT2D PYGO2 ATN1 ARID2 ZMIZ2 TNS2 MLLT6 ZFHX3 TRIM24 CREBBP RAI1 NPAS2	1.59e-11	254	78	13	int:CRX
Interaction	EGR2 interactions	NCOA3 KMT2D PYGO2 ATN1 ARID2 ZMIZ2 ZFHX3 SSBP2 TRIM24 CREBBP	1.14e-09	171	78	10	int:EGR2
Interaction	TLE3 interactions	SRRT NCOA3 KMT2D PYGO2 ATN1 SCAF8 ARID2 ZMIZ2 MLLT6 ZFHX3 ZNF362 CREBBP	2.14e-08	376	78	12	int:TLE3
Interaction	SP7 interactions	SRRT NCOA3 KMT2D PYGO2 ATN1 RBM33 SCAF8 ARID2 ZMIZ2 TRIM24 CREBBP	2.44e-08	304	78	11	int:SP7
Interaction	AR interactions	SRRT NCOA3 KMT2D PYGO2 ATN1 RBM33 ARID2 ZMIZ2 SREBF1 ZFHX3 SSBP2 ZNF362 GNAS SRCAP KLF4 TRIM24 CREBBP RAI1	3.19e-08	992	78	18	int:AR
Interaction	ETV4 interactions	NCOA3 KMT2D PYGO2 ZMIZ2 TRIM24 CREBBP	2.73e-07	69	78	6	int:ETV4
Interaction	NUP35 interactions	NCOA3 GSX1 KMT2D PYGO2 ATN1 RBM33 SCAF8 TRIM24 CREBBP PAIP1 RAI1	6.89e-07	424	78	11	int:NUP35
Interaction	PAX9 interactions	NCOA3 KMT2D PYGO2 ATN1 ZMIZ2 ZFHX3 KLF4	7.13e-07	130	78	7	int:PAX9
Interaction	HNF1B interactions	NCOA3 POU6F2 KMT2D ARID2 MLLT6 ZFHX3 TRIM24 CREBBP	7.19e-07	190	78	8	int:HNF1B
Interaction	SOX7 interactions	NCOA3 KMT2D ARID2 ZMIZ2 TRIM24 CREBBP	7.66e-07	82	78	6	int:SOX7
Interaction	TLE5 interactions	FOXN1 UBAP2 ATN1 MED25 TNS2 DMRTB1 MLLT6 ZFHX3 KLF4 VPS37B GPANK1	1.06e-06	443	78	11	int:TLE5
Interaction	PAX6 interactions	NCOA3 KMT2D ARID2 MLLT6 ZFHX3 SRCAP TRIM24 CREBBP GPANK1 SHANK3	1.45e-06	366	78	10	int:PAX6
Interaction	LHX8 interactions	FOXN1 KMT2D PYGO2 ARID2 SSBP2	1.89e-06	53	78	5	int:LHX8
Interaction	TOP3B interactions	FOXO3 SH3PXD2B KMT2D UBAP2 SARS2 IER5L RBM33 FASTK ZMIZ2 ARHGAP44 SREBF1 MLLT6 GNAS SYVN1 SRCAP KLF4 WNK1 PAIP1 RAI1	2.33e-06	1470	78	19	int:TOP3B
Interaction	WWTR1 interactions	ATXN2L SH3PXD2B KMT2D UBAP2 ARID2 MED28 ENAH PTPN23 SRCAP CREBBP	5.15e-06	422	78	10	int:WWTR1
Interaction	TLX1 interactions	NCOA3 KMT2D PYGO2 ATN1 ZFHX3 SSBP2 CREBBP	5.19e-06	175	78	7	int:TLX1
Interaction	CERS2 interactions	NCOA3 INA ASGR2 ENAH SSBP2 GNAS SYVN1 CREBBP	5.40e-06	249	78	8	int:CERS2
Interaction	TBXT interactions	NCOA3 KMT2D ATN1 SSBP2 TRIM24 CREBBP	5.85e-06	116	78	6	int:TBXT
Interaction	ETS1 interactions	NCOA3 KMT2D ARID2 SRCAP TRIM24 CREBBP	7.46e-06	121	78	6	int:ETS1
Interaction	HOXB2 interactions	KMT2D ZMIZ2 TRIM24 CREBBP	1.11e-05	36	78	4	int:HOXB2
Interaction	GATA2 interactions	NCOA3 KMT2D ARID2 ZFHX3 SSBP2 TRIM24 CREBBP	1.20e-05	199	78	7	int:GATA2
Interaction	TLX3 interactions	NCOA3 POU6F2 KMT2D PYGO2 ARID2 ZMIZ2 ZFHX3 TRIM24	1.68e-05	291	78	8	int:TLX3
Interaction	CREBBP interactions	FOXO3 NCOA3 KMT2D PYGO2 SREBF1 MED25 SRCAP KLF4 TRIM24 CREBBP NPAS2	1.87e-05	599	78	11	int:CREBBP
Interaction	IRF4 interactions	NCOA3 KMT2D PYGO2 ARID2 ZMIZ2	1.96e-05	85	78	5	int:IRF4
Interaction	NPAS2 interactions	NCOA3 UBAP2 CREBBP NPAS2	2.08e-05	42	78	4	int:NPAS2
Interaction	GSC interactions	NCOA3 KMT2D ATN1 ZFHX3 CREBBP	2.20e-05	87	78	5	int:GSC
Interaction	BCL9L interactions	SH3PXD2B PYGO2 SSBP2 SHANK3	3.55e-05	48	78	4	int:BCL9L
Interaction	EYA4 interactions	ATXN2L NCOA3 ATN1 RBM33 ZMIZ2 VPS37B CREBBP	4.34e-05	243	78	7	int:EYA4
Interaction	MAPK1 interactions	FOXO3 NCOA3 SARS2 ENAH SREBF1 PTPN23 TNS2 CREBBP SHANK3 RAI1	4.51e-05	543	78	10	int:MAPK1
Interaction	LHX1 interactions	KMT2D PYGO2 ARID2 SSBP2 TRIM24	4.97e-05	103	78	5	int:LHX1
Interaction	ASF1A interactions	KMT2D ARID2 MLLT6 ZNF362 SRCAP TRIM24 RAI1	5.06e-05	249	78	7	int:ASF1A
Interaction	ALG13 interactions	NCOA3 KMT2D ATN1 RBM33 SCAF8 DMRTB1	7.72e-05	183	78	6	int:ALG13
Interaction	LHX3 interactions	KMT2D PYGO2 ARID2 SSBP2 TRIM24 CREBBP	8.19e-05	185	78	6	int:LHX3
Interaction	CTBP2 interactions	FOXO3 UBAP2 ARHGAP44 GDF6 PTPN23 DMRTB1 KLF4 CREBBP	9.16e-05	370	78	8	int:CTBP2
Interaction	HNF4A interactions	NCOA3 KMT2D ARID2 SREBF1 SRCAP TRIM24 CREBBP	9.44e-05	275	78	7	int:HNF4A
Interaction	KLF5 interactions	NCOA3 KMT2D ARID2 SREBF1 TRIM24 CREBBP	1.09e-04	195	78	6	int:KLF5
Interaction	PIN1 interactions	FOXN1 NCOA3 ATN1 ZMIZ2 TNS2 MLLT6 SSBP2 RAI1	1.16e-04	383	78	8	int:PIN1
Interaction	PAX7 interactions	NCOA3 KMT2D PYGO2 ZFHX3 CREBBP	1.20e-04	124	78	5	int:PAX7
Interaction	FEV interactions	NCOA3 KMT2D ARID2 ZFHX3 TRIM24 CREBBP	1.36e-04	203	78	6	int:FEV
Interaction	MED15 interactions	MED28 SREBF1 MED25 MLLT6 SRCAP	1.55e-04	131	78	5	int:MED15
Interaction	MYB interactions	KMT2D MLLT6 ZFHX3 CREBBP PAIP1	1.67e-04	133	78	5	int:MYB
Interaction	HGS interactions	POU6F2 UBAP2 ATN1 MED25 PTPN23 KLF4 VPS37B SHANK3 NPAS2	1.85e-04	523	78	9	int:HGS
Interaction	PPARG interactions	NCOA3 KMT2D ARID2 MLLT6 KLF4 TRIM24 CREBBP	1.86e-04	307	78	7	int:PPARG
Interaction	FOXO3B interactions	FOXO3 FOXO3B	2.20e-04	6	78	2	int:FOXO3B
Interaction	MEGF11 interactions	ATN1 SHANK3	2.20e-04	6	78	2	int:MEGF11
Interaction	SMG7 interactions	NCOA3 KMT2D RBM33 SCAF8 MLLT6 TRIM24 CREBBP	2.35e-04	319	78	7	int:SMG7
Interaction	NFIX interactions	FOXN1 KMT2D ARID2 ZFHX3 SRCAP TRIM24	2.50e-04	227	78	6	int:NFIX
Interaction	ASB13 interactions	POU6F2 UBAP2 ZMIZ2	2.80e-04	33	78	3	int:ASB13
Interaction	RBPMS interactions	POU6F2 UBAP2 ATN1 FASTK NYNRIN TNS2 DMRTB1	3.46e-04	340	78	7	int:RBPMS
Interaction	SOX6 interactions	NCOA3 PYGO2 RBM33 ZMIZ2 ZFHX3	3.59e-04	157	78	5	int:SOX6
Interaction	EFS interactions	AGXT GPANK1 NPAS2	3.94e-04	37	78	3	int:EFS
Interaction	SOX5 interactions	KMT2D PYGO2 RBM33 ZFHX3 TRIM24	4.15e-04	162	78	5	int:SOX5
Interaction	SOX10 interactions	NCOA3 POU6F2 KMT2D ARID2	4.48e-04	92	78	4	int:SOX10
Interaction	FOXI1 interactions	NCOA3 KMT2D TRIM24 CREBBP	4.48e-04	92	78	4	int:FOXI1
Interaction	LHX4 interactions	KMT2D PYGO2 ARID2 SSBP2 TRIM24	4.64e-04	166	78	5	int:LHX4
Interaction	MED25 interactions	MED28 SREBF1 MED25 CREBBP	4.67e-04	93	78	4	int:MED25
Interaction	RXRA interactions	NCOA3 MED25 TRIM24 CREBBP NPAS2	5.03e-04	169	78	5	int:RXRA
Interaction	SOX17 interactions	NCOA3 KMT2D ARID2 TRIM24	5.06e-04	95	78	4	int:SOX17
Interaction	LY6G6D interactions	LY6G6D SYVN1	5.23e-04	9	78	2	int:LY6G6D
Interaction	TFF1 interactions	NCOA3 MED25 CREBBP	5.35e-04	41	78	3	int:TFF1
Interaction	TSC1 interactions	FOXO3 POU6F2 ATN1 SREBF1 TNS2 GPANK1 SHANK3	5.38e-04	366	78	7	int:TSC1
Interaction	SOX9 interactions	NCOA3 KMT2D ARID2 CREBBP	5.48e-04	97	78	4	int:SOX9
Interaction	SS18L1 interactions	ATN1 ARID2 ZMIZ2 CREBBP	5.69e-04	98	78	4	int:SS18L1
Interaction	RELA interactions	NCOA3 POU6F2 KMT2D SREBF1 ZFHX3 KLF4 CREBBP GLIS1	5.70e-04	485	78	8	int:RELA
Interaction	TEAD1 interactions	KMT2D ARID2 ZFHX3 SSBP2 CREBBP	6.05e-04	176	78	5	int:TEAD1
Interaction	IGSF9 interactions	IGSF9 SHANK3	6.52e-04	10	78	2	int:IGSF9
Interaction	LHX2 interactions	KMT2D ARID2 ZFHX3 SSBP2 TRIM24	7.22e-04	183	78	5	int:LHX2
GeneFamily	PHD finger proteins	KMT2D PYGO2 MLLT6 TRIM24	1.50e-04	90	54	4	88
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA3 CREBBP	1.16e-03	17	54	2	486
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOA3 KMT2D	2.51e-03	25	54	2	775
GeneFamily	Basic helix-loop-helix proteins	NCOA3 SREBF1 NPAS2	4.34e-03	110	54	3	420
GeneFamily	Cyclins\|Mediator complex	MED28 MED25	4.36e-03	33	54	2	1061
GeneFamily	Cytochrome P450 family 2	CYP2B6 CYP2E1	4.89e-03	35	54	2	1001
Coexpression	AIZARANI_LIVER_C33_STELLATE_CELLS_2	GJA4 TSC22D1 ATN1 ENAH ZFHX3 GNAS	2.28e-06	126	79	6	M39132
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	ATXN2L SRRT KMT2D ATN1 RBM33 ZMIZ2 SRCAP SEC31B	8.29e-06	338	79	8	M17094
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	KMT2D PYGO2 ASGR2 ARID2 MLLT6 RAI1	3.20e-05	200	79	6	M9439
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 TSC22D1 CADPS ZFHX3 GNAS	1.03e-05	162	79	5	c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 TSC22D1 CADPS ZFHX3 GNAS	1.03e-05	162	79	5	f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 TSC22D1 CADPS ZFHX3 GNAS	1.03e-05	162	79	5	5d902bb31e691aea9749617cc88303c2448f24b8
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA4 NRXN2 GNAS SHANK3 GLIS1	1.13e-05	165	79	5	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA4 NRXN2 GNAS SHANK3 GLIS1	1.13e-05	165	79	5	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA4 NRXN2 GNAS SHANK3 GLIS1	1.13e-05	165	79	5	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GJA4 NRXN2 GNAS SHANK3 GLIS1	1.13e-05	165	79	5	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	control-Others-CD34+_GATA2+_cells\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GJA4 TSC22D1 NYNRIN IGSF9 SHANK3	1.63e-05	178	79	5	2120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 CADPS ARHGAP44 TNS2 ZFHX3	1.96e-05	185	79	5	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 CADPS ARHGAP44 TNS2 ZFHX3	1.96e-05	185	79	5	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	B4GALNT1 CYP2E1 SSBP2 CHKA KLF4	2.34e-05	192	79	5	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GJA4 TSC22D1 TNS2 KLF4 SHANK3	2.78e-05	199	79	5	a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	POU6F2 INA ATN1 NRXN2 ZFHX3	2.85e-05	200	79	5	c92e4fc0442404481fcac623d691dae6215b852d
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	ATXN2L SRRT GJA4 ATN1 CYP2E1 NYNRIN ZNF362 GRM1 SRCAP	3.15e-08	200	79	9	6470_UP
Drug	4-vinylcyclohexene	FOXO3 CYP2B6 CYP2E1	1.39e-06	7	79	3	CID000007499
Drug	SBFI	SARS2 AGXT GRM1 CREBBP	3.43e-06	30	79	4	CID000123881
Drug	Methotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; PC3; HT_HG-U133A	THEMIS2 NCOA3 ATN1 ZMIZ2 CHKA SRCAP KLF4	4.11e-06	188	79	7	3701_UP
Drug	7-butoxycoumarin	CYP2B6 CYP2E1	1.19e-05	2	79	2	CID000156219
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	SH3PXD2B ATN1 PTPN23 ZFHX3 SRCAP	3.11e-05	104	79	5	ctd:C000595015
Drug	2,2-dichloro-1,1,1-trifluoroethane	CYP2B6 CYP2E1	3.56e-05	3	79	2	ctd:C067411
Drug	AC1ND2OB	FOXO3 FOXN1 NCOA3 CYP2B6 CYP2E1 TRIM24 CREBBP	3.79e-05	265	79	7	CID004568637
Drug	methyleugenol	TSC22D1 CYP2B6 CYP2E1	5.11e-05	21	79	3	CID000007127
Drug	Carbarsone [121-59-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A	ATXN2L ATN1 CYP2E1 NYNRIN MED25 ZNF362	5.71e-05	193	79	6	3250_UP
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ATXN2L SRRT ZMIZ2 GNAS GRM1 SRCAP	6.22e-05	196	79	6	4416_DN
Drug	novobiocin sodium, USP; Down 200; 100uM; PC3; HG-U133A	NCOA3 CYP2B6 B4GALNT1 ZMIZ2 CHKA NPAS2	6.40e-05	197	79	6	435_DN
Drug	Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	THEMIS2 ATN1 MED25 GNAS GRM1 CREBBP	6.40e-05	197	79	6	3357_UP
Drug	Dichlorphenamide [120-97-8]; Up 200; 13.2uM; HL60; HT_HG-U133A	GJA4 CYP2E1 MED25 ZFHX3 GNAS GRM1	6.58e-05	198	79	6	3027_UP
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A	SRRT ATN1 ZMIZ2 MED25 TNS2 SRCAP	6.76e-05	199	79	6	4297_DN
Drug	Trichlorfon [52-68-6]; Up 200; 15.6uM; PC3; HT_HG-U133A	THEMIS2 ATXN2L CYP2E1 MED25 TNS2 SRCAP	6.76e-05	199	79	6	7287_UP
Drug	Methantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SRRT ZMIZ2 ZNF362 SRCAP WNK1 CREBBP	6.76e-05	199	79	6	3560_UP
Drug	Carcinine [56897-53-1]; Up 200; 22uM; MCF7; HT_HG-U133A	ATXN2L CYP2B6 CYP2E1 MED25 GRM1 WNK1	6.95e-05	200	79	6	4809_UP
Drug	Tropicamide [1508-75-4]; Up 200; 14uM; MCF7; HT_HG-U133A	GJA4 INA ATN1 ZMIZ2 GRM1 SRCAP	6.95e-05	200	79	6	3619_UP
Drug	chlorfluazuron	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:C057223
Drug	7-ethoxy-4-trifluoromethylcoumarin	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:C056033
Drug	2-nitrophenol	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:C045573
Drug	N,N-diethyl-3-hydroxymethylbenzamide	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:C454677
Drug	5-methoxy-N,N-diisopropyltryptamine	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:C033696
Drug	Benzphetamine	CYP2B6 CYP2E1	7.10e-05	4	79	2	ctd:D001589
Drug	NSC-60	INA MED28	7.10e-05	4	79	2	CID000094713
Disease	neuroticism measurement, cognitive function measurement	FOXO3 ATXN2L POU6F2 TTBK1 ZMIZ2 ENAH ZFHX3 SSBP2 RAI1 NPAS2	2.43e-06	566	78	10	EFO_0007660, EFO_0008354
Disease	dermoid cyst of ovary (implicated_via_orthology)	FOXO3 FOXO3B	6.90e-06	2	78	2	DOID:5117 (implicated_via_orthology)
Disease	Obesity	FOXO3 CYP2E1 SREBF1 ZFHX3 GNAS RAI1	1.77e-05	205	78	6	C0028754
Disease	haloacid dehalogenase-like hydrolase domain-containing protein 2 measurement	NLRP12 SKOR2	2.07e-05	3	78	2	EFO_0801664
Disease	transmembrane protein 230 measurement	NLRP12 SH3PXD2B	4.12e-05	4	78	2	EFO_0802156
Disease	nicotine use	DMRTB1 GLIS1	2.45e-04	9	78	2	EFO_0005430
Disease	Pseudohypoaldosteronism, Type I	GNAS WNK1	3.06e-04	10	78	2	C0268436
Disease	Pseudohypoaldosteronism	GNAS WNK1	3.06e-04	10	78	2	C0033805
Disease	Hyperpotassemia and Hypertension, Familial	GNAS WNK1	3.06e-04	10	78	2	C2713447
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	GNAS WNK1	3.06e-04	10	78	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	GNAS WNK1	3.06e-04	10	78	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	GNAS WNK1	3.06e-04	10	78	2	C1449842
Disease	obesity (biomarker_via_orthology)	FOXO3 FOXO3B CYP2B6 CYP2E1	6.34e-04	147	78	4	DOID:9970 (biomarker_via_orthology)
Disease	Lymphoma, Follicular, Grade 2	KMT2D CREBBP	7.08e-04	15	78	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	KMT2D CREBBP	7.08e-04	15	78	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	KMT2D CREBBP	7.08e-04	15	78	2	C1956130
Disease	Lymphoma, Large-Cell, Follicular	KMT2D CREBBP	7.08e-04	15	78	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	KMT2D CREBBP	7.08e-04	15	78	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	KMT2D CREBBP	7.08e-04	15	78	2	C0079758
Disease	breast carcinoma (is_marker_for)	NCOA3 KMT2D ZFHX3	7.21e-04	66	78	3	DOID:3459 (is_marker_for)
Disease	dyslexia	FOXO3 POU6F2 IER5L COG5	9.11e-04	162	78	4	EFO_0005424
Disease	DiGeorge syndrome (implicated_via_orthology)	FOXN1 ZNF366	1.15e-03	19	78	2	DOID:11198 (implicated_via_orthology)
Disease	Intellectual Disability	ATN1 NRXN2 PTPN23 GNAS SHANK3 RAI1	1.20e-03	447	78	6	C3714756
Disease	Prostatic Neoplasms	NCOA3 KMT2D CYP2E1 ARID2 ZFHX3 SSBP2 CREBBP	1.23e-03	616	78	7	C0033578
Disease	Malignant neoplasm of prostate	NCOA3 KMT2D CYP2E1 ARID2 ZFHX3 SSBP2 CREBBP	1.23e-03	616	78	7	C0376358
Disease	Lymphoma, Follicular	KMT2D CREBBP	1.27e-03	20	78	2	C0024301
Disease	hepatocellular carcinoma (is_implicated_in)	CYP2E1 ARID2 ZFHX3 KLF4	1.37e-03	181	78	4	DOID:684 (is_implicated_in)
Disease	Autism Spectrum Disorders	NRXN2 SHANK3 RAI1	1.50e-03	85	78	3	C1510586
Disease	body weight	FOXO3 ATXN2L SH3PXD2B USF3 CADPS ZMIZ2 ZFHX3 SSBP2 GNAS TRIM24	1.76e-03	1261	78	10	EFO_0004338
Disease	Adenocarcinoma of lung (disorder)	FOXO3 FASTK WNK1 CREBBP	2.20e-03	206	78	4	C0152013
Disease	Schizophrenia	NRXN2 CYP2E1 SREBF1 GNAS GRM1 SHANK3 RAI1 NPAS2	2.30e-03	883	78	8	C0036341
Disease	Sezary Syndrome	KMT2D CREBBP	2.32e-03	27	78	2	C0036920
Disease	Adenoid Cystic Carcinoma	FOXO3 SRCAP CREBBP	2.39e-03	100	78	3	C0010606
Disease	anterior thigh muscle fat infiltration measurement	ATXN2L NPAS2	2.49e-03	28	78	2	EFO_0020936

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGQPQRIPLPGQPLQ	GNAS	321	P84996
GQPLQPQPILTPGQP	GNAS	331	P84996
TQGLPLPQPLLPPGQ	GNAS	431	P84996
LPQPLLPPGQPKSAG	GNAS	436	P84996
LPPGQPKSAGRPLQP	GNAS	441	P84996
APLPPQPQNGLGRAP	MLLT6	856	P55198
PPGPRPLPLLGNLLQ	CYP2B6	31	P20813
GFLPPLNVNLNPPIP	ANKRD34C	461	P0C6C1
PPNPRLYPPGSLPQG	B4GALNT1	256	Q00973
LNPRRGNPFLKGPPP	ASGR2	31	P07307
GNPFLKGPPPAQPLA	ASGR2	36	P07307
GLNPLPNPSYLLPPR	INA	416	Q16352
RIPYPAGTLPNPLLP	ATN1	1091	P54259
DEVPPGNPKPQLPIG	ARID2	111	Q68CP9
PQAQPVRPPNGPLSL	CREBBP	696	Q92793
RGAEGILAPQPPPPQ	ATXN2L	71	Q8WWM7
PPPPQQPLAYPKLQR	RAI1	176	Q7Z5J4
PPRQPFLPGPGQPFL	RBM33	556	Q96EV2
NLPPGPFPLPIIGNL	CYP2E1	31	P05181
VLGQPPPPLHTQLYP	PTPN23	1006	Q9H3S7
LGYPQPPPAQPQPLR	NPAS2	791	Q99743
PKVPNLPVNIPLGIP	CADPS	1026	Q9ULU8
KPPPPLQPLLRGGQG	FASTK	191	Q14296
VYIPPQQPQPPGGGL	KLF4	211	O43474
SQGPQPPNLPLGVPI	GPANK1	241	O95872
HPQLKLPQLPPRVPG	FAM205A	1116	Q6ZU69
QLHGPPGPPALPLLK	GSX1	66	Q9H4S2
LQPLLENPPLGPGAP	NRXN2	1571	Q9P2S2
KPPQLLIPPLGTFGP	KCNH4	806	Q9UQ05
PALLPPPHQGLGQPQ	MED25	676	Q71SY5
PPHQGLGQPQLGPPL	MED25	681	Q71SY5
PPQAPPGLPGQASLL	MED28	16	Q9H204
PQPKAPGFLQPPPLR	PAIP1	46	Q9H074
PSLNIPYGIRNLPPP	PRR27	36	Q6MZM9
PLQRPGQGLPSLPPN	PYGO2	226	Q9BRQ0
PINLVFPPGGRNPPS	COG5	496	Q9UP83
LLQPQQPLPPPQPGA	FOXO3B	211	A0A2Z4LIS9
PLPPQPQFLPPGYLS	DMRTB1	276	Q96MA1
KQLGGQQPPLALPPP	CHKA	46	P35790
PSQQGIVLGPLAPPP	ENAH	301	Q8N8S7
PLFLDPPPQNGQKPP	GJA4	306	P35212
QQGLPPPYPLSQLPP	GLIS1	161	Q8NBF1
EPALPKGLPPPLQQQ	GRM1	1006	Q13255
LLGTQPPAGPQNLPP	SCAF8	896	Q9UPN6
IPQAPGPRFPLIQPG	SCAF8	931	Q9UPN6
RGQPLEPLQPGPAPL	IER5L	171	Q5T953
PLGPIQLKLPGQNPL	NYNRIN	396	Q9P2P1
RPQPGLEQIKLPGNP	LY6G6D	46	O95868
LLQPQQPLPPPQPGA	FOXO3	126	O43524
GPQQPPPPDLRSLGF	GDF6	251	Q6KF10
IGPNQPRKPGLPGQP	SARS2	501	Q9NP81
PLLPQPPNFPQGLLP	SYVN1	361	Q86TM6
YPGGPRPPLRIPNQA	SSBP2	131	P81877
PNQLLLGPGPSNLPP	AGXT	21	P21549
PGGPPALNQPILIPF	POU6F2	111	P78424
LHPAPGPIPGKNPLQ	FOXN1	426	O15353
YRPNPNPVGQGIRPP	NCOA3	376	Q9Y6Q9
LAQKLGLIGPPPPPL	RNF32	91	Q9H0A6
TPLPGAPPPQQLQYG	TSC22D1	616	Q15714
APGPQAIQPLPLSPG	SEC31B	866	Q9NQW1
PVLEPQLIPGPQPLG	SRCAP	2906	Q6ZRS2
QLIPGPQPLGPQPVH	SRCAP	2911	Q6ZRS2
LAPIPPKVPFGQPGA	ARHGAP44	651	Q17R89
SPPGNTQQPLPGLPL	SREBF1	176	P36956
KPAQPPGPAQILPPG	SRRT	766	Q9BXP5
PGQPLQPQPLGPYLR	LINC00173	71	Q6ZV60
PNGPVLPPHPQQLRY	TRIM24	526	O15164
GKAPPNLPQGVPPLL	UBAP2	791	Q5T6F2
GEERPPGPQPQLQLP	USP43	76	Q70EL4
LPPQPLPPQLSQGDG	TTBK1	611	Q5TCY1
PGAPGPRRPFQQKPL	SHANK3	1651	Q9BYB0
RGLNLPKPPIPPQVE	SH3PXD2B	356	A1X283
EIQAPPPRPPKNQGL	THEMIS2	546	Q5TEJ8
LQQPQPLPPPSGIHL	PSORS1C1	111	Q9UIG5
ANQNPLPLLPAPPPG	USF3	586	Q68DE3
PLPGPGPLLQYLSLP	IGSF9	916	Q9P2J2
PGGLPVPTYLQPPPQ	SKOR2	476	Q2VWA4
YPGPPQAQPLPRQGV	ZMIZ2	251	Q8NF64
LPPLGGAPQPLNPHK	UBAP1L	241	F5GYI3
PLEGSFQPGRQIPPP	nan	91	Q5W150
NHGLPNLPLLFPQPP	ZNF366	106	Q8N895
NPGGPPVLVVPYPIL	ZNF362	201	Q5T0B9
PVGQPLPTPLLPQYP	WNK1	826	Q9H4A3
QLLQPPGPLGPLTPL	TRIM65	251	Q6PJ69
QAVPYPGLQCPPLPP	VPS37B	231	Q9H9H4
PPLPPRVGLPTQQGF	VPS37B	241	Q9H9H4
PPLPEKRHLPGPGQQ	TNS2	1071	Q63HR2
PLQTLPAQLPPQLGP	ZFHX3	2106	Q15911
LPGQLLPGHGLQPPQ	KMT2D	3631	O14686
KPGAPRLQPPPNQRG	NLRP12	446	P59046