Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal inhibitory synapse morphology

INSYN1 SUSD4

5.99e-058212MP:0020358
DomainSAM_DOMAIN

GAREM2 L3MBTL3

5.53e-0395222PS50105
DomainSAM/pointed

GAREM2 L3MBTL3

8.28e-03117222IPR013761
Pubmed

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.

BMP5 CHRDL2

1.64e-05924214660436
Pubmed

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

JPH1 DYSF

3.00e-051224223715556
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

TMEM209 LARP1 WEE1 RPRD2

2.20e-0444024434244565
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

MAP1S LARP1 CDK17 DOCK8

2.31e-0444624424255178
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

TMEM209 L3MBTL3 RPRD2

2.55e-0418024335198878
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

LARP1 CDK17 WEE1

2.98e-0419024315161933
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

JPH1 TMEM209 LARP1

3.03e-0419124331177093
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MAP1S LARP1 CDK17 DOCK8 CRACD DENND2A

3.41e-04143124637142655
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

LARP1 L3MBTL3 DENND2A RPRD2

4.42e-0452924414621295
ToppCellParenchymal-10x3prime_v2-Hematologic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GAREM2 L3MBTL3

8.12e-05252427b267cdcb6afcf603d566c4d5268eb44eacf47b6
ToppCellParenchymal-10x3prime_v2-Hematologic-Erythrocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GAREM2 L3MBTL3

8.12e-0525242096ca30d9277cfd9cb2501c40b085cc358cb628b
ToppCellParenchymal-10x3prime_v2-Hematologic-Erythrocyte-Erythrocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GAREM2 L3MBTL3

8.12e-05252423d7b43ecf6ae64996d91765c50f614742e18bd25
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAREM2 CRACD DENND2A

8.30e-05159243cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAREM2 CRACD DENND2A

8.30e-05159243330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

8.77e-05162243373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JPH1 CRACD DENND2A

1.12e-04176243792f414f5092aba14260b8e16378e793a822498e
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAOB DENND2A BMP5

1.16e-0417824309475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAOB DENND2A BMP5

1.16e-0417824335de8f791b0e78a6caf52ff095f05e204a59e828
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAOB DENND2A BMP5

1.16e-04178243000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK8 CRACD DENND2A

1.18e-041792430b6731d9554f8bed1899c165a50e6b329ea19a6d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.24e-04182243a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellGlobus_pallidus-Neuronal-Inhibitory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LARP1 CRACD PANX2

1.24e-0418224304ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCellCOVID-19-Heart-Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

DENND2A BMP5 SUSD4

1.28e-0418424321790cdfa3b4036ad413fd44b94e31563116f25f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.28e-04184243d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.34e-0418724387b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.34e-0418724377886f99c229610abd28c4c370d2c7d1536c9782
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

CRACD DENND2A BMP5

1.34e-04187243bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.34e-0418724342a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.34e-0418724364afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

MAOB DENND2A BMP5

1.34e-0418724392d468dde81125d51daf7abd4703741abe1ab91c
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)-|390C / Donor, Lineage, Cell class and subclass (all cells)

DYSF DENND2A CHRDL2

1.36e-041882431f40b959777d18ad88d239df8cca304f062ba04c
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)|390C / Donor, Lineage, Cell class and subclass (all cells)

DYSF DENND2A CHRDL2

1.36e-04188243aa69e3f44d506f5ef358a3374ac5160d847c858f
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.38e-04189243a153b83314cf52808f685296cff8c95af3f4983d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.38e-04189243e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WEE1 DENND2A SUSD4

1.38e-04189243e059be2965cca70ff5576df055d0af1775b76e00
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.38e-041892432a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

MAOB DENND2A BMP5

1.41e-041902433a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MAOB DENND2A BMP5

1.43e-041912436688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MAOB DENND2A BMP5

1.45e-0419224399ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.45e-04192243dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.45e-041922436f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.45e-04192243f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.45e-04192243deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.47e-04193243fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.47e-04193243acad568621ed677031797b8c2e34dafea798d681
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.47e-04193243b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

CRACD DENND2A BMP5

1.47e-04193243e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.47e-04193243ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAOB DENND2A BMP5

1.49e-0419424360622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.49e-04194243011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

CRACD DENND2A BMP5

1.49e-0419424303a269f75a481ea54aea8e6444605db8d6df493d
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.52e-0419524361c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

MAOB DENND2A BMP5

1.52e-04195243603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.52e-04195243aa0add081881d349099d12efca5cdee098038d4e
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MAOB DENND2A BMP5

1.54e-041962437d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MAOB CRACD BMP5

1.56e-04197243f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

MAOB DENND2A BMP5

1.59e-04198243df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DYSF DENND2A CHRDL2

1.59e-04198243306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Proliferative_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MAOB DENND2A CHRDL2

1.59e-0419824377c81ec602ab553a544c3d9b1e66181b6f000d12
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MAOB DENND2A BMP5

1.59e-041982438f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

MAOB DENND2A BMP5

1.59e-0419824326e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DYSF DENND2A CHRDL2

1.59e-0419824305429f18e1d74880c1835568c86177f661b3477a
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

CRACD DENND2A BMP5

1.61e-041992435b9d355795dd03a22f0961dfd143425c367a4654
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAOB DENND2A BMP5

1.63e-04200243cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAOB DENND2A BMP5

1.63e-04200243e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAOB DENND2A BMP5

1.63e-04200243311fab076f2ceb258e3970eb21e39344b894042a
ToppCellBronchial-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DYSF DENND2A CHRDL2

1.63e-04200243c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCellBronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DYSF DENND2A CHRDL2

1.63e-04200243e50ef394e3284a8323bfd60575b262b2be422aea
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAOB DENND2A BMP5

1.63e-0420024334f52003988ce6329d8deeee1ab875fa77e01e9d
Diseasesusceptibility to cold sores measurement

DYSF BMP5

1.17e-0365232EFO_0008402
Diseasevital capacity

L3MBTL3 C3orf49 DENND2A BMP5 RPRD2

2.29e-031236235EFO_0004312
Diseaseosteoarthritis, hip

BMP5 RPRD2

2.33e-0392232EFO_1000786
DiseaseS-warfarin to R-warfarin ratio measurement

CRACD CHRDL2

2.48e-0395232EFO_0803331
Diseaseforced expiratory volume

LARP1 L3MBTL3 C3orf49 RPRD2

3.00e-03789234EFO_0004314
Diseasefacial morphology measurement

DYSF L3MBTL3 BMP5

5.48e-03466233EFO_0007841
Diseasemyeloid white cell count

CCDC125 DOCK8 L3MBTL3 C3orf49

5.53e-03937234EFO_0007988
Diseasecolorectal cancer, colorectal adenoma

BMP5 CHRDL2

6.21e-03152232EFO_0005406, MONDO_0005575
Diseasedyslexia

INSYN1 PANX2

7.03e-03162232EFO_0005424

Protein segments in the cluster

PeptideGeneStartEntry
HKPSPAPYKSRRSPL

INSYN1

231

Q2T9L4
PAPARAFKVKPPHGF

L3MBTL3

461

Q96JM7
HVKGKSYPFRGPFPP

MAOB

91

P27338
GSARRPRPPCAKPHK

LARP1

51

Q6PKG0
KPRKAPSTSHSGFPP

MAP1S

561

Q66K74
PPTPKESPHFYRKGT

JPH1

446

Q9HDC5
GPHGPSPKKFYPRFT

GALNT11

46

Q8NCW6
YTGSFKKPPLRRPHS

CDK17

61

Q00537
APLSFIPRHFRPKGA

CHRDL2

221

Q6WN34
GPYSPKKRPHFPALK

C3orf49

191

Q96BT1
RSDGKNFSPPPFPRK

CCDC125

51

Q86Z20
PSSPAAPRPASKKHF

DOCK8

946

Q8NF50
PFINPLPKPRRTFKH

DENND2A

261

Q9ULE3
PVKPSRPKRHFSSAG

CRACD

121

Q6ZU35
KRFTRKPSPKPTFGP

CCDC191

21

Q8NCU4
LPHRPRPFSPGKQAS

BMP5

61

P22003
DPFHSLKRPRPPFAR

RPRD2

1431

Q5VT52
SRPPPHYPGIKRKRS

DYSF

191

O75923
PPPAPDKKHARHFSL

PANX2

501

Q96RD6
KKHRPPGPLFSSSDP

nan

276

A6NNC1
REPQSRKEPHKPPFF

MINAR1

286

Q9UPX6
CPPLFKPSHPQKRFA

GAREM2

611

Q75VX8
PGTPPHKTFRKLRLF

WEE1

171

P30291
KFKAHFPPRGPPRSS

SUSD4

346

Q5VX71
RLPPHPKYPDGKTFT

TMEM209

461

Q96SK2