Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retinoic acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.33e-06	28	59	4	GO:0001972
GeneOntologyMolecularFunction	protein kinase C binding	NELL1 UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.47e-06	66	59	5	GO:0005080
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.36e-06	35	59	4	GO:0015020
GeneOntologyMolecularFunction	retinoid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.21e-05	48	59	4	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.32e-05	49	59	4	GO:0019840
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9 ALG11 ST6GALNAC6 MGAT5B	2.17e-05	288	59	7	GO:0016757
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9 ALG11 MGAT5B	3.66e-05	211	59	6	GO:0016758
GeneOntologyMolecularFunction	fatty acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.15e-05	69	59	4	GO:0005504
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9 MGAT5B	8.87e-05	153	59	5	GO:0008194
GeneOntologyMolecularFunction	monocarboxylic acid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.83e-04	107	59	4	GO:0033293
GeneOntologyMolecularFunction	protein homodimerization activity	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 XPA NFS1 CEP57 STAT5B	6.05e-04	815	59	9	GO:0042803
GeneOntologyMolecularFunction	steroid binding	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.45e-04	133	59	4	GO:0005496
GeneOntologyMolecularFunction	Wnt receptor activity	FZD5 RYK	1.13e-03	17	59	2	GO:0042813
GeneOntologyMolecularFunction	enzyme inhibitor activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9 ADGRV1 SSPOP	1.75e-03	435	59	6	GO:0004857
GeneOntologyMolecularFunction	molecular function inhibitor activity	UGT1A10 UGT1A8 UGT1A7 UGT1A9 KCNAB1 ADGRV1 SSPOP	1.81e-03	596	59	7	GO:0140678
GeneOntologyMolecularFunction	protein dimerization activity	PPP3CB UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 XPA NFS1 CEP57 STAT5B	2.59e-03	1205	59	10	GO:0046983
GeneOntologyBiologicalProcess	estrogen catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.23e-10	5	60	4	GO:0006711
GeneOntologyBiologicalProcess	phenylpropanoid catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.66e-10	6	60	4	GO:0046271
GeneOntologyBiologicalProcess	coumarin catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.66e-10	6	60	4	GO:0046226
GeneOntologyBiologicalProcess	flavone metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.66e-10	6	60	4	GO:0051552
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.34e-08	10	60	4	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.34e-08	10	60	4	GO:0009804
GeneOntologyBiologicalProcess	flavonoid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.54e-08	13	60	4	GO:0009812
GeneOntologyBiologicalProcess	flavonoid glucuronidation	UGT1A8 UGT1A7 UGT1A9	2.33e-07	5	60	3	GO:0052696
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.73e-07	21	60	4	GO:0052695
GeneOntologyBiologicalProcess	hormone catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.73e-07	21	60	4	GO:0042447
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.22e-07	26	60	4	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.22e-07	26	60	4	GO:0006063
GeneOntologyBiologicalProcess	steroid catabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.81e-06	34	60	4	GO:0006706
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT1A8 UGT1A7 UGT1A9	5.05e-06	12	60	3	GO:0052697
GeneOntologyBiologicalProcess	estrogen metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.58e-05	52	60	4	GO:0008210
GeneOntologyBiologicalProcess	liver development	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 STAT5B	2.64e-05	202	60	6	GO:0001889
GeneOntologyBiologicalProcess	hepaticobiliary system development	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 STAT5B	2.87e-05	205	60	6	GO:0061008
GeneOntologyBiologicalProcess	secondary metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.32e-05	67	60	4	GO:0019748
GeneOntologyBiologicalProcess	xenobiotic metabolic process	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.61e-05	141	60	5	GO:0006805
GeneOntologyBiologicalProcess	pigment metabolic process	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.62e-04	94	60	4	GO:0042440
GeneOntologyBiologicalProcess	hormone metabolic process	DUOX1 UGT1A10 UGT1A8 UGT1A7 UGT1A9 STAT5B	1.80e-04	286	60	6	GO:0042445
GeneOntologyBiologicalProcess	retinoic acid metabolic process	UGT1A8 UGT1A7 UGT1A9	2.14e-04	40	60	3	GO:0042573
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	4.66e-04	222	60	5	GO:0071466
GeneOntologyBiologicalProcess	positive regulation of myoblast differentiation	NEU2 DPF3 ACTL6A	5.22e-04	54	60	3	GO:0045663
GeneOntologyBiologicalProcess	T cell homeostasis	PPP3CB AHR STAT5B	6.78e-04	59	60	3	GO:0043029
MousePheno	absent cochlear hair bundle ankle links	MYO7A ADGRV1	8.81e-06	2	42	2	MP:0004582
MousePheno	abnormal cochlear hair bundle ankle links morphology	MYO7A ADGRV1	8.81e-06	2	42	2	MP:0004581
Domain	UDPGT	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.53e-07	21	60	4	PF00201
Domain	UDPGT	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.53e-07	21	60	4	PS00375
Domain	UDP_glucos_trans	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.53e-07	21	60	4	IPR002213
Domain	EPTP	LGI3 ADGRV1	1.51e-04	6	60	2	PF03736
Domain	EPTP	LGI3 ADGRV1	1.51e-04	6	60	2	IPR005492
Domain	EAR	LGI3 ADGRV1	2.11e-04	7	60	2	IPR009039
Domain	EAR	LGI3 ADGRV1	2.11e-04	7	60	2	PS50912
Domain	MYTH4	MYO7A MYO7B	3.60e-04	9	60	2	PS51016
Domain	MyTH4_dom	MYO7A MYO7B	3.60e-04	9	60	2	IPR000857
Domain	MyTH4	MYO7A MYO7B	3.60e-04	9	60	2	PF00784
Domain	MyTH4	MYO7A MYO7B	3.60e-04	9	60	2	SM00139
Domain	VWC_out	NELL1 SSPOP	1.68e-03	19	60	2	SM00215
Domain	TSPN	NELL1 COL14A1	2.46e-03	23	60	2	SM00210
Domain	Ig_E-set	NFATC2 NXPE4 ASCC3	4.56e-03	104	60	3	IPR014756
Domain	ConA-like_dom	NELL1 TRIM62 COL14A1 ADGRV1	5.37e-03	219	60	4	IPR013320
Domain	-	NFS1 GPT2	5.64e-03	35	60	2	3.90.1150.10
Domain	VWFC_1	NELL1 SSPOP	5.96e-03	36	60	2	PS01208
Domain	PyrdxlP-dep_Trfase_major_sub2	NFS1 GPT2	5.96e-03	36	60	2	IPR015422
Domain	VWC	NELL1 SSPOP	6.62e-03	38	60	2	SM00214
Domain	Myosin_head_motor_dom	MYO7A MYO7B	6.62e-03	38	60	2	IPR001609
Domain	VWFC_2	NELL1 SSPOP	6.62e-03	38	60	2	PS50184
Domain	MYOSIN_MOTOR	MYO7A MYO7B	6.62e-03	38	60	2	PS51456
Domain	Myosin_head	MYO7A MYO7B	6.62e-03	38	60	2	PF00063
Domain	MYSc	MYO7A MYO7B	6.62e-03	38	60	2	SM00242
Domain	-	NFS1 GPT2	6.97e-03	39	60	2	3.40.640.10
Pathway	WP_ESTROGEN_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.27e-07	22	48	4	MM15888
Pathway	REACTOME_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.20e-06	24	48	4	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.42e-06	25	48	4	M17787
Pathway	WP_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.42e-06	25	48	4	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.42e-06	25	48	4	M605
Pathway	WP_GLUCURONIDATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.67e-06	26	48	4	M39404
Pathway	KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.28e-06	28	48	4	M19580
Pathway	REACTOME_PARACETAMOL_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.92e-06	39	48	4	MM15695
Pathway	KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.09e-05	41	48	4	M7399
Pathway	WP_CODEINE_AND_MORPHINE_METABOLISM	UGT1A10 UGT1A8 UGT1A9	1.31e-05	14	48	3	M39328
Pathway	REACTOME_ASPIRIN_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.59e-05	45	48	4	MM15694
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.63e-05	51	48	4	M17726
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.84e-05	52	48	4	M14171
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.55e-05	55	48	4	M14933
Pathway	KEGG_RETINOL_METABOLISM	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.47e-05	64	48	4	M9488
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.20e-05	70	48	4	M16794
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.03e-04	72	48	4	M9257
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION	UGT1A10 UGT1A8 UGT1A7 UGT1A9 KCNAB1	1.66e-04	153	48	5	MM15844
Pathway	REACTOME_CALCINEURIN_ACTIVATES_NFAT	PPP3CB NFATC2	4.03e-04	9	48	2	M27106
Pathway	REACTOME_ASPIRIN_ADME	UGT1A8 UGT1A7 UGT1A9	4.45e-04	44	48	3	M45014
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.72e-04	107	48	4	MM14595
Pathway	WP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873	UGT1A7 AHR UGT1A9	4.76e-04	45	48	3	M39615
Pathway	REACTOME_DRUG_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.06e-04	109	48	4	M45012
Pathway	REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.06e-04	109	48	4	M18788
Pathway	WP_WNT_SIGNALING_WP428	PPP3CB NFATC2 FZD5 RYK	5.80e-04	113	48	4	M39669
Pathway	REACTOME_CALCINEURIN_ACTIVATES_NFAT	PPP3CB NFATC2	6.12e-04	11	48	2	MM14810
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	PPP3CB NFATC2	6.12e-04	11	48	2	M27466
Pathway	REACTOME_DRUG_ADME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.05e-04	119	48	4	MM15692
Pathway	WP_IRINOTECAN_PATHWAY	UGT1A10 UGT1A9	7.33e-04	12	48	2	M39611
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY	PPP3CB NFATC2	7.33e-04	12	48	2	M47956
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	8.60e-04	219	48	5	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	8.77e-04	220	48	5	M10320
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CB NFATC2	1.32e-03	16	48	2	MM1483
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	PPP3CB NFATC2	1.32e-03	16	48	2	M47449
Pathway	WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.47e-03	145	48	4	M45512
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN	PPP3CB NFATC2	1.49e-03	17	48	2	M47560
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PPP3CB NFATC2	1.68e-03	18	48	2	M3430
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	FZD5 SSPOP	1.68e-03	18	48	2	M31
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY	PPP3CB NFATC2	1.68e-03	18	48	2	M47580
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CB NFATC2	1.68e-03	18	48	2	M5290
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PPP3CB NFATC2	1.68e-03	18	48	2	MM1385
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PPP3CB NFATC2	1.87e-03	19	48	2	M47543
Pathway	WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS	PPP3CB NFATC2	2.07e-03	20	48	2	M48330
Pathway	WP_TAMOXIFEN_METABOLISM	UGT1A10 UGT1A8	2.29e-03	21	48	2	M39631
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY	PPP3CB NFATC2	2.29e-03	21	48	2	M47542
Pathway	REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN	NEU2 ALG11 ST6GALNAC6	2.44e-03	79	48	3	M897
Pathway	WP_ESTROGEN_METABOLISM_WP5276	UGT1A10 UGT1A8	2.99e-03	24	48	2	M46445
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CB NFATC2	3.24e-03	25	48	2	MM1441
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CB NFATC2	3.24e-03	25	48	2	M1547
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	UGT1A10 UGT1A7 UGT1A9 KCNAB1	3.43e-03	183	48	4	M39588
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CB NFATC2	3.50e-03	26	48	2	M17941
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CB NFATC2	3.50e-03	26	48	2	MM1371
Pubmed	Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.20e-10	6	60	4	32527940
Pubmed	Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.20e-10	6	60	4	20297805
Pubmed	Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.79e-10	7	60	4	8467709
Pubmed	Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.79e-10	7	60	4	8464825
Pubmed	Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.79e-10	7	60	4	27514509
Pubmed	Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.57e-10	8	60	4	17179145
Pubmed	Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.57e-10	8	60	4	20610558
Pubmed	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.57e-10	8	60	4	18052087
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	9	60	4	22511988
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.67e-09	10	60	4	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.67e-09	10	60	4	11465080
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.67e-09	10	60	4	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.67e-09	10	60	4	22558097
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.92e-09	12	60	4	20308471
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.92e-09	12	60	4	19419973
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.92e-09	12	60	4	11434514
Pubmed	Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.	UGT1A10 UGT1A8 UGT1A9	4.88e-09	3	60	3	29519853
Pubmed	Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.	UGT1A10 UGT1A8 UGT1A9	4.88e-09	3	60	3	12847094
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.65e-09	13	60	4	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.65e-09	13	60	4	25246029
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.91e-09	14	60	4	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.91e-09	14	60	4	10836148
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.91e-09	14	60	4	14672974
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.91e-09	14	60	4	9295054
Pubmed	Genome-wide association meta-analysis for total serum bilirubin levels.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.43e-08	16	60	4	19414484
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.87e-08	17	60	4	20639394
Pubmed	Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A16 and 28.	UGT1A10 UGT1A7 UGT1A9	1.95e-08	4	60	3	17558305
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.40e-08	18	60	4	20056724
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.04e-08	19	60	4	23281178
Pubmed	Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.	UGT1A8 UGT1A7 UGT1A9	4.87e-08	5	60	3	20565459
Pubmed	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	UGT1A10 UGT1A8 UGT1A9	4.87e-08	5	60	3	15057901
Pubmed	Human metabolic individuality in biomedical and pharmaceutical research.	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.04e-08	57	60	5	21886157
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.28e-08	24	60	4	24625756
Pubmed	Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.	UGT1A10 UGT1A8 UGT1A9	4.07e-07	9	60	3	20732626
Pubmed	An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.	MYO7A MGAT5B RASD2	7.97e-07	11	60	3	28729444
Pubmed	Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.	UGT1A8 UGT1A7 UGT1A9	7.97e-07	11	60	3	18695635
Pubmed	An atlas of genetic influences on human blood metabolites.	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 CRAT	9.62e-07	190	60	6	24816252
Pubmed	Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells.	NELL1 NFATC2	2.93e-06	2	60	2	21611965
Pubmed	Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.	UGT1A10 UGT1A9	2.93e-06	2	60	2	25547628
Pubmed	Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues.	UGT1A10 UGT1A8	2.93e-06	2	60	2	11901093
Pubmed	Negative cross talk between NFAT1 and Stat5 signaling in breast cancer.	NFATC2 STAT5B	2.93e-06	2	60	2	21964595
Pubmed	Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene.	UGT1A7 UGT1A9	2.93e-06	2	60	2	11677206
Pubmed	Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.	UGT1A10 UGT1A9	2.93e-06	2	60	2	22031623
Pubmed	Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.	PPP3CB NFATC2	2.93e-06	2	60	2	11030334
Pubmed	Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10.	UGT1A10 UGT1A8	2.93e-06	2	60	2	10497143
Pubmed	Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.	UGT1A8 UGT1A9	2.93e-06	2	60	2	18568343
Pubmed	Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.	UGT1A10 UGT1A8	2.93e-06	2	60	2	17603215
Pubmed	UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.	UGT1A7 UGT1A9	2.93e-06	2	60	2	15709193
Pubmed	Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.	UGT1A7 UGT1A9	2.93e-06	2	60	2	12944498
Pubmed	Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon.	UGT1A10 UGT1A8	2.93e-06	2	60	2	9647757
Pubmed	Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	UGT1A7 UGT1A9	2.93e-06	2	60	2	17529886
Pubmed	How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?	UGT1A10 UGT1A9	2.93e-06	2	60	2	20089735
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.32e-06	66	60	4	19898482
Pubmed	Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.	UGT1A7 UGT1A9	8.77e-06	3	60	2	19364970
Pubmed	Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.	UGT1A7 UGT1A9	8.77e-06	3	60	2	16636344
Pubmed	Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.	UGT1A10 UGT1A9	8.77e-06	3	60	2	20007669
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid.	UGT1A8 UGT1A9	8.77e-06	3	60	2	23721685
Pubmed	Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.	UGT1A10 UGT1A8	8.77e-06	3	60	2	19244109
Pubmed	Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.	UGT1A8 UGT1A9	8.77e-06	3	60	2	26247833
Pubmed	The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers.	UGT1A8 UGT1A9	8.77e-06	3	60	2	17339869
Pubmed	Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.	UGT1A7 UGT1A9	8.77e-06	3	60	2	24453052
Pubmed	Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia.	DPF3 STAT5B	8.77e-06	3	60	2	24155890
Pubmed	UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients.	UGT1A8 UGT1A9	8.77e-06	3	60	2	19225446
Pubmed	[Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G].	UGT1A7 UGT1A9	8.77e-06	3	60	2	23789755
Pubmed	Targeted next generation sequencing in Italian patients with Usher syndrome: phenotype-genotype correlations.	MYO7A ADGRV1	8.77e-06	3	60	2	29142287
Pubmed	Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer.	UGT1A7 UGT1A9	8.77e-06	3	60	2	17406868
Pubmed	Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.	UGT1A8 UGT1A7	8.77e-06	3	60	2	19996319
Pubmed	Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.	UGT1A8 UGT1A9	8.77e-06	3	60	2	16397224
Pubmed	Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients.	UGT1A8 UGT1A9	1.75e-05	4	60	2	18946804
Pubmed	Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.	AHR RYK	1.75e-05	4	60	2	7613029
Pubmed	Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients.	UGT1A8 UGT1A9	1.75e-05	4	60	2	20147615
Pubmed	Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.	PPP3CB NFATC2	1.75e-05	4	60	2	9660947
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	MYO7A ADGRV1	1.75e-05	4	60	2	18463160
Pubmed	UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.	UGT1A7 UGT1A9	1.75e-05	4	60	2	20628391
Pubmed	Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.	PPP3CB NFATC2	1.75e-05	4	60	2	23962643
Pubmed	Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.	UGT1A10 UGT1A7	1.75e-05	4	60	2	9271343
Pubmed	Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp.	PPP3CB NFATC2	1.75e-05	4	60	2	11970967
Pubmed	Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.	UGT1A8 UGT1A9	1.75e-05	4	60	2	23700788
Pubmed	Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.	UGT1A10 UGT1A9	1.75e-05	4	60	2	2108603
Pubmed	Defective T cell development and function in calcineurin A beta -deficient mice.	PPP3CB NFATC2	1.75e-05	4	60	2	12091710
Pubmed	Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.	UGT1A7 UGT1A9	2.92e-05	5	60	2	18597651
Pubmed	The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.	NELL1 MGAT5B	2.92e-05	5	60	2	22823124
Pubmed	The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C.	UGT1A10 UGT1A7	2.92e-05	5	60	2	18556656
Pubmed	Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.	UGT1A7 UGT1A9	2.92e-05	5	60	2	17072959
Pubmed	Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.	UGT1A7 UGT1A9	4.37e-05	6	60	2	19204906
Pubmed	A common protein interaction domain links two recently identified epilepsy genes.	LGI3 ADGRV1	4.37e-05	6	60	2	12095917
Pubmed	The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.	LGI3 ADGRV1	4.37e-05	6	60	2	12217514
Pubmed	Tails of unconventional myosins.	MYO7A MYO7B	6.11e-05	7	60	2	11212352
Pubmed	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.	UGT1A8 UGT1A9	8.14e-05	8	60	2	12695355
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	MYO7A ADGRV1	8.14e-05	8	60	2	19683999
Pubmed	Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.	UGT1A8 UGT1A7	8.14e-05	8	60	2	15319294
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A8 UGT1A9	1.05e-04	9	60	2	1339448
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	MYO7A ADGRV1	1.31e-04	10	60	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	MYO7A ADGRV1	1.31e-04	10	60	2	24239741
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	MYO7A ADGRV1	1.31e-04	10	60	2	17329413
Pubmed	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	UGT1A7 UGT1A9	1.91e-04	12	60	2	19349540
Pubmed	Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.	MYO7A STAT5B	1.91e-04	12	60	2	17331196
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	MYO7A ADGRV1	2.63e-04	14	60	2	26754646
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYO7A MYO7B	2.63e-04	14	60	2	8022818
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	ZNF555 ZNF280D FBXO3 FZD5 ACTL6A ADGRV1 ASCC3	3.02e-04	750	60	7	11230166
Interaction	UGT1A9 interactions	UGT1A10 UGT1A7 UGT1A9	6.34e-06	13	58	3	int:UGT1A9
Interaction	UGT1A7 interactions	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.18e-05	57	58	4	int:UGT1A7
Interaction	UGT1A8 interactions	UGT1A8 UGT1A7	2.44e-05	3	58	2	int:UGT1A8
Cytoband	2q37	NEU2 UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.32e-10	31	60	5	2q37
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	NEU2 UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.21e-05	226	60	5	chr2q37
GeneFamily	UDP glucuronosyltransferases	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.63e-07	32	42	4	363
GeneFamily	A-kinase anchoring proteins\|Myosins, class VII\|Deafness associated genes\|FERM domain containing	MYO7A MYO7B	5.27e-06	2	42	2	1102
Drug	1,4-dihydroxyanthraquinone	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.97e-12	8	60	5	ctd:C034890
Drug	2,6-dihydroxyanthraquinone	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	2.67e-11	10	60	5	ctd:C034889
Drug	2,4,6-TCB	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	8.37e-11	12	60	5	CID000037247
Drug	alizarin	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	1.36e-10	13	60	5	ctd:C010078
Drug	PCB-61	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	2.11e-10	14	60	5	CID000036401
Drug	naringenin chalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.17e-10	5	60	4	ctd:C027329
Drug	anthrarobin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.17e-10	5	60	4	ctd:C032186
Drug	2,2',3,5,5'-pentachlorobiphenyl	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	3.15e-10	15	60	5	CID000040469
Drug	bergamottin	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	3.15e-10	15	60	5	ctd:C068337
Drug	1,2,5,8-tetrahydroxy anthraquinone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.51e-10	6	60	4	ctd:C543211
Drug	alloin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.51e-10	6	60	4	ctd:C006457
Drug	2',5'-dihydroxychalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.51e-10	6	60	4	ctd:C107497
Drug	2,3,7-trichlorodibenzo-p-dioxin	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	8.94e-10	18	60	5	CID000036614
Drug	2',4'-dihydroxychalcone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.52e-09	7	60	4	ctd:C059354
Drug	phenanthroline	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 ADGRV1	3.76e-09	50	60	6	CID000067473
Drug	AC1MRQNQ	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.44e-09	9	60	4	CID003522271
Drug	DHPASiU	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.44e-09	9	60	4	CID000197602
Drug	Chebi:32663	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.44e-09	9	60	4	CID005460873
Drug	3-iodophenol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.44e-09	9	60	4	CID000012272
Drug	AC1L4J7U	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.44e-09	9	60	4	CID000186631
Drug	5,6-benzoquinoline	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.47e-09	25	60	5	CID000006796
Drug	1-naphthol	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 ADGRV1 GPT2	7.06e-09	98	60	7	CID000007005
Drug	licochalcone A	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	8.28e-09	27	60	5	ctd:C070840
Drug	4-nitrophenyl)imidazole	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.42e-08	11	60	4	CID000123155
Drug	AC1O5XMV	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.42e-08	11	60	4	CID006442661
Drug	PCB 156	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	1.73e-08	31	60	5	CID000038019
Drug	N-OH-DABZ	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.12e-08	12	60	4	CID000051366
Drug	1-O-beta-D-glucopyranosyl-D-mannitol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.12e-08	12	60	4	CID000088735
Drug	4-hydroxyestrone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.12e-08	12	60	4	ctd:C026418
Drug	7,7,7-triphenylheptanoic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.12e-08	12	60	4	CID000276709
Drug	nonanoyl-N-methylglucamide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.12e-08	12	60	4	CID000160090
Drug	2-hydroxyestrone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.06e-08	13	60	4	ctd:C024980
Drug	tritanol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.06e-08	13	60	4	CID000006457
Drug	5-azido-UDP-glucuronic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.06e-08	13	60	4	CID003081279
Drug	cotinine-N-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.06e-08	13	60	4	CID000000411
Drug	AC1L9DGV	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	3.80e-08	36	60	5	CID000417381
Drug	propranolol glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.28e-08	14	60	4	CID000119515
Drug	6beta-hydroxytestosterone	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	4.38e-08	37	60	5	CID000065543
Drug	N-benzylformamide	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 GPT2	4.91e-08	76	60	6	CID000080654
Drug	x Me	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.03e-08	38	60	5	CID009600424
Drug	4-methylumbelliferyl glucuronide	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.03e-08	38	60	5	CID000091553
Drug	1-phenylimidazole	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	5.76e-08	39	60	5	CID000081595
Drug	coumarin-3-carboxylic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.82e-08	15	60	4	CID000010752
Drug	sulforaphane nitrile	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.82e-08	15	60	4	CID000543743
Drug	afloqualone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.82e-08	15	60	4	CID000002040
Drug	naphthyl sulphate	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.82e-08	15	60	4	CID000114775
Drug	4-hydroxyestradiol	EIF2S1 UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	6.20e-08	79	60	6	CID000001743
Drug	thymoquinone	UGT1A10 UGT1A8 UGT1A7 UGT1A9 GPT2	6.57e-08	40	60	5	CID000010281
Drug	2-vanillin	UGT1A10 UGT1A8 UGT1A7	6.95e-08	4	60	3	ctd:C060843
Drug	hydratropic acid	UGT1A10 UGT1A8 UGT1A7	6.95e-08	4	60	3	ctd:C013025
Drug	diphenylacetic acid	UGT1A10 UGT1A8 UGT1A7	6.95e-08	4	60	3	ctd:C037760
Drug	quercetin-3,4'-diglucoside	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.74e-08	16	60	4	CID005320835
Drug	1'-hydroxyestragole	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.74e-08	16	60	4	CID000040003
Drug	bilirubin-phosphate	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.74e-08	16	60	4	CID005497144
Drug	7,8-benzoquinoline	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	9.56e-08	43	60	5	CID000009191
Drug	3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	17	60	4	CID000003573
Drug	6-hydroxychrysene	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.01e-07	17	60	4	CID000037766
Drug	anthraflavic acid	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	1.08e-07	44	60	5	CID000006776
Drug	pentoxyresorufin	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 GPT2	1.11e-07	87	60	6	CID000107683
Drug	ethyl-beta-D-6-glucosiduronic acid	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID000152226
Drug	Br 2	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID003060900
Drug	SureCN12722713	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID005488034
Drug	ApApG	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID003081975
Drug	C1 11-32	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID000443077
Drug	C11131	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.30e-07	18	60	4	CID000443076
Drug	almokalant	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.64e-07	19	60	4	CID003033962
Drug	9-OH-risperidone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.64e-07	19	60	4	CID000475100
Drug	5alpha-spirostan-3beta-ol	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.64e-07	19	60	4	CID000091433
Drug	1-hydroxypyrene	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	1.68e-07	48	60	5	CID000021387
Drug	isovaleric acid	UGT1A10 UGT1A8 UGT1A7	1.73e-07	5	60	3	ctd:C008216
Drug	biphenylylacetic acid	UGT1A10 UGT1A8 UGT1A7	1.73e-07	5	60	3	ctd:C012776
Drug	EM-652	UGT1A10 UGT1A8 UGT1A7 UGT1A9 RYK	1.87e-07	49	60	5	CID000155435
Drug	TCPOBOP	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 GPT2	1.88e-07	95	60	6	CID000005382
Drug	tectochrysin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.05e-07	20	60	4	CID005281954
Drug	AC1L1OBF	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.05e-07	20	60	4	CID000032736
Drug	4'-hydroxydiclofenac	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.05e-07	20	60	4	CID000116545
Drug	entacapone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.05e-07	20	60	4	ctd:C071192
Drug	p,p'-hydroxy-DDT	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	2.07e-07	50	60	5	CID000076302
Drug	estriol-16-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.52e-07	21	60	4	CID000122281
Drug	dulcin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.52e-07	21	60	4	CID000009013
Drug	Benzamidoxime hydrochloride	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.52e-07	21	60	4	CID000069186
Drug	HCG 004	UGT1A10 UGT1A8 UGT1A7 UGT1A9 CRAT	3.07e-07	54	60	5	CID000064928
Drug	amonafide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.08e-07	22	60	4	CID000050515
Drug	plumbagin	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.08e-07	22	60	4	ctd:C014758
Drug	N-methylpiperazine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.08e-07	22	60	4	CID000053167
Drug	3-phenylpropionic acid	UGT1A10 UGT1A8 UGT1A7	3.46e-07	6	60	3	ctd:C035253
Drug	Indoprofen	UGT1A10 UGT1A8 UGT1A7	3.46e-07	6	60	3	ctd:D007216
Drug	amidoxime	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.72e-07	23	60	4	CID000465967
Drug	estradiol-3-glucuronide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.72e-07	23	60	4	CID000066651
Drug	phenanthridine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.72e-07	23	60	4	CID000009189
Drug	morin	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	4.41e-07	58	60	5	ctd:C008548
Drug	AS-3201	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.45e-07	24	60	4	CID000153948
Drug	4-hydroxyestrone	UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9	4.81e-07	59	60	5	CID000018418
Drug	fisetin	NFATC2 UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.24e-07	60	60	5	ctd:C017875
Drug	5-MOP	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-07	25	60	4	CID000002355
Drug	Hymecromone	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-07	25	60	4	ctd:D006923
Drug	AzMC	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-07	25	60	4	CID000064986
Drug	N-acetylbenzidine	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-07	25	60	4	CID000018787
Drug	N-phenylmaleimide	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.29e-07	25	60	4	CID000013662
Drug	3-OH	ARAP3 UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.70e-07	61	60	5	CID000068152
Disease	N-acetyl-4-chlorophenylalanine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.20e-11	5	59	4	EFO_0801060
Disease	5-hydroxyindole sulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.20e-11	5	59	4	EFO_0800085
Disease	nuclear receptor subfamily 1 group D member 2 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.20e-11	5	59	4	EFO_0801853
Disease	X-21339 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.02e-10	7	59	4	EFO_0800808
Disease	X-11793--oxidized bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0021260
Disease	Succinimide measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0022118
Disease	X-11530 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0800696
Disease	X-10458 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0800692
Disease	X-24849 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0800909
Disease	serum N-desmethylclozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0600043
Disease	plasma clozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0600038
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0802740
Disease	X-16946 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.00e-09	8	59	4	EFO_0800766
Disease	X-11442 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0021236
Disease	X-11441 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0801037
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0802127
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0801036
Disease	X-11880 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0800698
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0004570, GO_0009410
Disease	protein-tyrosine kinase 6 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.80e-09	9	59	4	EFO_0020691
Disease	X-21448 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.00e-09	10	59	4	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.00e-09	10	59	4	EFO_0802185
Disease	X-23974 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.00e-09	10	59	4	EFO_0800867
Disease	bilirubin measurement, response to tenofovir	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.00e-09	10	59	4	EFO_0004570, EFO_0009279
Disease	X-21796 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0800825
Disease	pregnenetriol sulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0800586
Disease	plasma N-desmethylclozapine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0600039
Disease	insomnia, bilirubin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0800972
Disease	aldosterone measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.71e-09	11	59	4	EFO_0010219
Disease	biliverdin measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.05e-09	12	59	4	EFO_0021033
Disease	p-cresol glucuronide measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	7.05e-09	12	59	4	EFO_0800079
Disease	blood 4-oxo-retinoic acid measurement	UGT1A10 UGT1A8 UGT1A9	7.59e-09	3	59	3	EFO_0022216
Disease	indole-3-carboxylate measurement	UGT1A10 UGT1A8 UGT1A9	7.59e-09	3	59	3	EFO_0800043
Disease	retinol dehydrogenase 16 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.02e-08	13	59	4	EFO_0802007
Disease	pregnenetriol disulfate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	1.02e-08	13	59	4	EFO_0800587
Disease	X-21441 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.36e-08	17	59	4	EFO_0800814
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.36e-08	17	59	4	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	4.32e-08	18	59	4	EFO_0801382
Disease	tissue factor measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	8.41e-08	21	59	4	EFO_0010623
Disease	3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) measurement	UGT1A10 UGT1A8 UGT1A9	1.51e-07	6	59	3	EFO_0800566
Disease	neuroblastoma, cutaneous melanoma	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.85e-07	28	59	4	EFO_0000389, EFO_0000621
Disease	xanthurenate measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.30e-07	29	59	4	EFO_0010551
Disease	response to dolutegravir	UGT1A10 UGT1A8 UGT1A7 UGT1A9	3.80e-07	30	59	4	EFO_0600017
Disease	indoleacetate measurement	UGT1A10 UGT1A8 UGT1A9	9.02e-07	10	59	3	EFO_0021015
Disease	vitamin D deficiency	UGT1A10 UGT1A8 UGT1A7 UGT1A9	9.06e-07	37	59	4	EFO_0003762
Disease	cholelithiasis	UGT1A10 UGT1A8 UGT1A7 NSD1 UGT1A9	9.27e-07	88	59	5	EFO_0004799
Disease	X-24588 measurement	UGT1A10 UGT1A8 UGT1A9	2.14e-06	13	59	3	EFO_0800898
Disease	vitamin D measurement, COVID-19	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.86e-06	49	59	4	EFO_0004631, MONDO_0100096
Disease	urate measurement, spine bone mineral density	UGT1A10 UGT1A8 UGT1A7 UGT1A9	5.64e-06	58	59	4	EFO_0004531, EFO_0007701
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	UGT1A10 UGT1A8 UGT1A7 UGT1A9 GPT2	1.16e-05	147	59	5	DOID:9352 (biomarker_via_orthology)
Disease	thyroxine measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.35e-05	83	59	4	EFO_0005130
Disease	hormone measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9	2.47e-05	84	59	4	EFO_0004730
Disease	bilirubin measurement	NEU2 UGT1A10 UGT1A8 UGT1A7 AHR UGT1A9 CRAT	2.81e-05	442	59	7	EFO_0004570
Disease	Intellectual Disability	HIVEP2 PITRM1 NSD1 XPA ACTL6A ASCC3 GPT2	3.02e-05	447	59	7	C3714756
Disease	gallstones	UGT1A10 UGT1A8 UGT1A7 UGT1A9	6.62e-05	108	59	4	EFO_0004210
Disease	Basal cell carcinoma	XPA STAT5B	2.14e-04	11	59	2	C0007117
Disease	dodecanedioate measurement	UGT1A10 UGT1A8	2.56e-04	12	59	2	EFO_0021054
Disease	temporal horn of lateral ventricle volume measurement	UGT1A10 UGT1A8 C1orf94	4.11e-04	72	59	3	EFO_0010333
Disease	intellectual disability (implicated_via_orthology)	HIVEP2 ZNF280D RYK	4.63e-04	75	59	3	DOID:1059 (implicated_via_orthology)
Disease	response to antineoplastic agent, response to antimicrotubule agent	AHR ADAMTS18	4.63e-04	16	59	2	EFO_0005260, GO_0097327
Disease	non-high density lipoprotein cholesterol measurement	UGT1A10 UGT1A8 UGT1A7 AHR NSD1 UGT1A9 ASCC3	5.35e-04	713	59	7	EFO_0005689
Disease	vitamin D measurement	UGT1A10 UGT1A8 UGT1A7 UGT1A9 C1orf94	5.62e-04	336	59	5	EFO_0004631
Disease	lobe attachment	NELL1 HIVEP2 NFATC2 ADAMTS18	7.92e-04	207	59	4	EFO_0007667
Disease	Splenomegaly	AHR STAT5B	8.85e-04	22	59	2	C0038002

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDRYVMPECFIQPGH	TDRD5	516	Q8NAT2
HKPGEMPYVCQVCNY	ZNF280D	411	Q6N043
AGAVSMYQCQPEPQH	AHR	766	P35869
NQMVIAFFHPYCNAG	ALG11	61	Q2TAA5
HCNPLQGAMYAFPRI	GPT2	431	Q8TD30
VHIMDPGCLYYGVQP	ARAP3	196	Q8WWN8
QMPTVHYEFPNGYNC	ACTL6A	281	O96019
CAQMEPNALPFRGIY	ADGRV1	5266	Q8WXG9
FGAQPHYRLCLGDMP	CEP57	276	Q86XR8
PDGYGVCYNPMEAHI	CRAT	571	P43155
RMPYQQALHPQLGCY	C1orf94	491	Q6P1W5
NRRACPAHPVYNMVA	ADAMTS18	1111	Q8TE60
PHLGVCPQYNVLFDM	ABCA7	881	Q8IZY2
PKGNYARFMNHCCQP	NSD1	2011	Q96L73
AAANPGYAFHPLMAA	OPN1LW	291	P04000
PGVYMRNASCHFQGV	DUOX1	336	Q9NRD9
QEFQHIMYCENFAPG	NFATC2	826	Q13469
VMNGDPKHHYPGCIN	NFS1	341	Q9Y697
DCDRGYHMYCLNPPV	DPF3	336	Q92784
MPGLSCRFYQHKFPE	EIF2S1	1	P05198
QFNMIPPVCEQAEYH	KCNAB1	256	Q14722
ESEMNHLYPAFAQPG	MGAT5B	736	Q3V5L5
VFYQCPDQMARNPAA	FBXO3	221	Q9UK99
YMGFPAVCAALEHPQ	RCE1	266	Q9Y256
IFQLPFCGPNIMDHY	OR4X1	161	Q8NH49
FMPNGYITQCPNLNH	NELL1	211	Q92832
GPNRVNHYFCDMAPV	OR10T2	171	Q8NGX3
GHRSMNPCPLYDAQT	NEU2	81	Q9Y3R4
CRGIGYNLTHMPNQF	FZD5	41	Q13467
MQYPKQGIFSVTCPH	DOCK9	456	Q9BZ29
ADHMPLNCFIPSGYN	CEP126	706	Q9P2H0
MEPGTFNVFPCYQLH	COL14A1	1251	Q05707
QQQMGRYPVHFHLCG	CEMIP2	541	Q9UHN6
NVMNIRQFNCSPHPY	PPP3CB	336	P16298
FPMDYHCLGDNENRP	RYK	491	P34925
MYQIPFCGPNIIDHF	OR4C6	161	Q8NH72
VPPAHCRCQYQPGAM	SSPOP	3581	A2VEC9
RDQEGFYCVRPQHMP	NXPE4	236	Q6UWF7
HFLMPFPVNYVGECI	PITRM1	856	Q5JRX3
CDHVHVYGMVPPNYC	ST6GALNAC6	256	Q969X2
MDQAPSPAVCPQAHY	STAT5B	726	P51692
PYGHFRIGQMKNCSP	POMK	56	Q9H5K3
IQGFPGQHYCPRMAS	ASCC3	1526	Q8N3C0
QYKCNVGHPPANEFM	ZNF555	591	Q8NEP9
NCHQGKPLPMEFEAY	UGT1A10	276	Q9HAW8
VQYGDAFHPRPFCMR	RASD2	206	Q96D21
NCHQGKPLPMEFEAY	UGT1A9	276	O60656
RCFPGYGMNVQQHPK	ZPBP	301	Q9BS86
YMDFRVFLGNPHVCN	ZSWIM2	51	Q8NEG5
VHQPGPVMEFDYVIC	XPA	91	P23025
DVYIGNHMPCPENLN	TMEFF1	266	Q8IYR6
FQFQYPTVCMVHLPA	HIVEP2	1206	P31629
QPSRGFYCIVMHDGN	TRIM62	381	Q9BVG3
NCHQGKPVPMEFEAY	UGT1A7	276	Q9HAW7
NYQRINHFPGMGEIC	TTLL7	91	Q6ZT98
EMFHPNIYPDGRVCI	UBE2G2	76	P60604
NCHQGKPLPMEFEAY	UGT1A8	276	Q9HAW9
QAPRAFCYMPAGDAQ	LGI3	511	Q8N145
PPHIFAIADNCYFNM	MYO7A	131	Q13402
PPHVFAIANNCYFSM	MYO7B	131	Q6PIF6