Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat kinase activity	CCNK BRD4	2.02e-04	10	43	2	GO:0008353
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN2 NLGN1	5.33e-04	16	43	2	GO:0042043
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXD3 DLX2 AHRR DLX3 ATOH1 EN2 FOXJ3 HELT HES7 NFX1	6.73e-04	1412	43	10	GO:0000981
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase adaptor activity	FRS3 IRS1	6.78e-04	18	43	2	GO:0005068
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXD3 DLX2 DLX3 ATOH1 EN2 FOXJ3 HELT EP300 HES7 NFX1	8.68e-04	1459	43	10	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat modifying activity	CCNK BRD4	1.11e-03	23	43	2	GO:0140994
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXD3 DLX2 DLX3 ATOH1 EN2 FOXJ3 HELT EP300 HES7	1.13e-03	1244	43	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXD3 DLX2 DLX3 ATOH1 EN2 FOXJ3 HELT EP300 HES7	1.31e-03	1271	43	9	GO:0000987
GeneOntologyMolecularFunction	acetylation-dependent protein binding	EP300 BRD4	2.02e-03	31	43	2	GO:0140033
GeneOntologyMolecularFunction	transcription coactivator activity	RERE KMT2E EP300 BRD4	4.03e-03	303	43	4	GO:0003713
GeneOntologyMolecularFunction	chromatin binding	DLX2 DLX3 RERE ATOH1 EP300 BRD4	4.78e-03	739	43	6	GO:0003682
GeneOntologyBiologicalProcess	thigmotaxis	NLGN2 EP300	2.54e-05	4	43	2	GO:0001966
GeneOntologyBiologicalProcess	positive regulation of protein localization to synapse	NLGN2 NLGN1	1.18e-04	8	43	2	GO:1902474
GeneOntologyBiologicalProcess	positive regulation of synaptic vesicle clustering	NLGN2 NLGN1	1.18e-04	8	43	2	GO:2000809
GeneOntologyBiologicalProcess	positive regulation of T-helper 17 cell lineage commitment	EP300 BRD4	1.18e-04	8	43	2	GO:2000330
GeneOntologyBiologicalProcess	embryo development	FOXD3 DLX2 DLX3 ATOH1 PTCH1 EN2 CCNK EP300 BRD4 HES7 SEC24B	1.30e-04	1437	43	11	GO:0009790
GeneOntologyBiologicalProcess	terminal button organization	NLGN2 NLGN1	1.51e-04	9	43	2	GO:0072553
GeneOntologyBiologicalProcess	neuron development	NLGN2 NLGN1 RERE ATOH1 PTCH1 EN2 NYAP1 ATXN2 MAP4K4 EP300 SEC24B	1.53e-04	1463	43	11	GO:0048666
GeneOntologyBiologicalProcess	multicellular organism growth	SIK3 PTCH1 ATXN2 HELT EP300	1.63e-04	249	43	5	GO:0035264
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN2 NLGN1	1.89e-04	10	43	2	GO:0097105
GeneOntologyBiologicalProcess	neuron projection morphogenesis	NLGN1 RERE ATOH1 PTCH1 NYAP1 ATXN2 MAP4K4 EP300	2.18e-04	802	43	8	GO:0048812
GeneOntologyBiologicalProcess	postsynaptic density protein 95 clustering	NLGN2 NLGN1	2.31e-04	11	43	2	GO:0097119
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN2 NLGN1	2.31e-04	11	43	2	GO:0097104
GeneOntologyBiologicalProcess	regulation of T-helper 17 cell lineage commitment	EP300 BRD4	2.31e-04	11	43	2	GO:2000328
GeneOntologyBiologicalProcess	neuron projection development	NLGN2 NLGN1 RERE ATOH1 PTCH1 NYAP1 ATXN2 MAP4K4 EP300 SEC24B	2.46e-04	1285	43	10	GO:0031175
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	NLGN1 RERE ATOH1 PTCH1 NYAP1 ATXN2 MAP4K4 EP300	2.52e-04	819	43	8	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	NLGN1 RERE ATOH1 PTCH1 NYAP1 ATXN2 MAP4K4 EP300	2.67e-04	826	43	8	GO:0048858
GeneOntologyBiologicalProcess	regulation of synaptic vesicle clustering	NLGN2 NLGN1	2.77e-04	12	43	2	GO:2000807
GeneOntologyBiologicalProcess	regulation of nervous system development	DLX2 NLGN2 NLGN1 ATOH1 HELT EP300 HES7	2.83e-04	625	43	7	GO:0051960
GeneOntologyBiologicalProcess	T-helper 17 type immune response	TRAF3IP2 EP300 BRD4	3.22e-04	64	43	3	GO:0072538
GeneOntologyBiologicalProcess	presynaptic membrane organization	NLGN2 NLGN1	3.26e-04	13	43	2	GO:0097090
GeneOntologyBiologicalProcess	regulation of respiratory gaseous exchange by nervous system process	NLGN2 NLGN1	3.80e-04	14	43	2	GO:0002087
GeneOntologyBiologicalProcess	positive regulation of T-helper 17 cell differentiation	EP300 BRD4	3.80e-04	14	43	2	GO:2000321
GeneOntologyBiologicalProcess	branching morphogenesis of a nerve	DLX2 RERE	4.38e-04	15	43	2	GO:0048755
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXD3 DLX2 DLX3 ATOH1 EN2 FOXJ3 CCNK HELT EP300 BRD4	4.61e-04	1390	43	10	GO:0045944
GeneOntologyBiologicalProcess	chordate embryonic development	FOXD3 DLX2 PTCH1 CCNK EP300 BRD4 HES7 SEC24B	4.96e-04	906	43	8	GO:0043009
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NLGN2 NLGN1	5.00e-04	16	43	2	GO:0007158
GeneOntologyBiologicalProcess	head development	DLX2 RERE ATOH1 PTCH1 EN2 ATXN2 EP300 SEC24B	5.45e-04	919	43	8	GO:0060322
GeneOntologyBiologicalProcess	regulation of respiratory system process	NLGN2 NLGN1	5.66e-04	17	43	2	GO:0044065
GeneOntologyBiologicalProcess	negative regulation of multicellular organism growth	PTCH1 ATXN2	5.66e-04	17	43	2	GO:0040015
GeneOntologyBiologicalProcess	hair cell differentiation	DLX3 ATOH1 SEC24B	5.76e-04	78	43	3	GO:0035315
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	FOXD3 DLX2 PTCH1 CCNK EP300 BRD4 HES7 SEC24B	5.85e-04	929	43	8	GO:0009792
GeneOntologyBiologicalProcess	positive regulation of cell fate commitment	EP300 BRD4	6.36e-04	18	43	2	GO:0010455
GeneOntologyBiologicalProcess	cell fate commitment	DLX2 ATOH1 PTCH1 EP300 BRD4	6.62e-04	338	43	5	GO:0045165
GeneOntologyBiologicalProcess	cell morphogenesis	NLGN1 RERE ATOH1 PTCH1 NYAP1 ATXN2 MAP4K4 EP300 SEC24B	6.69e-04	1194	43	9	GO:0000902
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission, GABAergic	NLGN2 NLGN1	7.88e-04	20	43	2	GO:0032230
GeneOntologyBiologicalProcess	modulation by host of symbiont process	CCNK EP300 BRD4	9.02e-04	91	43	3	GO:0051851
GeneOntologyBiologicalProcess	hindbrain development	RERE EN2 ATXN2 SEC24B	9.11e-04	208	43	4	GO:0030902
GeneOntologyBiologicalProcess	neurotransmitter-gated ion channel clustering	NLGN2 NLGN1	9.55e-04	22	43	2	GO:0072578
GeneOntologyBiologicalProcess	T-helper 17 cell lineage commitment	EP300 BRD4	9.55e-04	22	43	2	GO:0072540
GeneOntologyBiologicalProcess	synaptic vesicle clustering	NLGN2 NLGN1	9.55e-04	22	43	2	GO:0097091
GeneOntologyBiologicalProcess	somite development	PTCH1 EP300 HES7	9.91e-04	94	43	3	GO:0061053
GeneOntologyBiologicalProcess	embryonic organ development	FOXD3 DLX2 ATOH1 PTCH1 EN2 SEC24B	1.02e-03	561	43	6	GO:0048568
GeneOntologyBiologicalProcess	positive regulation of T-helper 17 type immune response	EP300 BRD4	1.04e-03	23	43	2	GO:2000318
GeneOntologyBiologicalProcess	GABAergic neuron differentiation	DLX2 HELT	1.14e-03	24	43	2	GO:0097154
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	TRAF3IP2 IRS1 NLGN1 SIK3 CHERP MAP4K4 EP300 BRD4 RAD9A	1.22e-03	1299	43	9	GO:1902533
GeneOntologyBiologicalProcess	regulation of AMPA receptor activity	NLGN2 NLGN1	1.24e-03	25	43	2	GO:2000311
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	FOXD3 DLX2 AHRR PTCH1 HELT EP300 HES7 NFX1	1.32e-03	1053	43	8	GO:0000122
GeneOntologyBiologicalProcess	T-helper cell lineage commitment	EP300 BRD4	1.44e-03	27	43	2	GO:0002295
GeneOntologyBiologicalProcess	regulation of respiratory gaseous exchange	NLGN2 NLGN1	1.44e-03	27	43	2	GO:0043576
GeneOntologyBiologicalProcess	inhibitory postsynaptic potential	NLGN2 NLGN1	1.44e-03	27	43	2	GO:0060080
GeneOntologyBiologicalProcess	viral gene expression	SHFL EP300 BRD4	1.52e-03	109	43	3	GO:0019080
GeneOntologyBiologicalProcess	positive regulation of epidermal cell differentiation	ATOH1 PTCH1	1.55e-03	28	43	2	GO:0045606
GeneOntologyBiologicalProcess	positive regulation of G2/M transition of mitotic cell cycle	DBF4B BRD4	1.78e-03	30	43	2	GO:0010971
GeneOntologyBiologicalProcess	brain development	DLX2 RERE ATOH1 PTCH1 EN2 ATXN2 SEC24B	1.84e-03	859	43	7	GO:0007420
GeneOntologyBiologicalProcess	positive regulation of mitotic cell cycle phase transition	KMT2E DBF4B BRD4	1.86e-03	117	43	3	GO:1901992
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell lineage commitment	EP300 BRD4	1.90e-03	31	43	2	GO:0043373
GeneOntologyBiologicalProcess	positive regulation of T-helper cell differentiation	EP300 BRD4	1.90e-03	31	43	2	GO:0045624
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	FOXD3 DLX2 AHRR RERE PTCH1 HELT EP300 HES7 NFX1	2.04e-03	1399	43	9	GO:0045892
GeneOntologyBiologicalProcess	alpha-beta T cell lineage commitment	EP300 BRD4	2.15e-03	33	43	2	GO:0002363
GeneOntologyBiologicalProcess	positive regulation of cell cycle G2/M phase transition	DBF4B BRD4	2.15e-03	33	43	2	GO:1902751
GeneOntologyBiologicalProcess	positive regulation of epidermis development	ATOH1 PTCH1	2.15e-03	33	43	2	GO:0045684
GeneOntologyBiologicalProcess	regulation of T-helper 17 cell differentiation	EP300 BRD4	2.15e-03	33	43	2	GO:2000319
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	FOXD3 DLX2 AHRR RERE PTCH1 HELT EP300 HES7 NFX1	2.19e-03	1413	43	9	GO:1902679
GeneOntologyBiologicalProcess	postsynaptic density assembly	NLGN2 NLGN1	2.28e-03	34	43	2	GO:0097107
GeneOntologyCellularComponent	chromatin	FOXD3 DLX2 AHRR DLX3 ATOH1 KMT2E EN2 FOXJ3 HELT DBF4B EP300 BRD4 HES7 NFX1	6.00e-07	1480	42	14	GO:0000785
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CCNK BRD4	1.41e-04	9	42	2	GO:0008024
GeneOntologyCellularComponent	protein kinase complex	IRS1 CCNK DBF4B BRD4	3.71e-04	170	42	4	GO:1902911
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CCNK BRD4	5.91e-04	18	42	2	GO:0019908
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	CCNK BRD4	1.06e-03	24	42	2	GO:0032806
GeneOntologyCellularComponent	inhibitory synapse	NLGN2 NLGN1	1.77e-03	31	42	2	GO:0060077
GeneOntologyCellularComponent	transferase complex	IRS1 WDFY3 CCNK DBF4B DCAF5 EP300 BRD4	2.83e-03	963	42	7	GO:1990234
GeneOntologyCellularComponent	serine/threonine protein kinase complex	CCNK DBF4B BRD4	3.85e-03	157	42	3	GO:1902554
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	IRS1 CCNK DBF4B BRD4	4.49e-03	335	42	4	GO:0061695
HumanPheno	Rib fusion	RERE PTCH1 BRD4 HES7	1.16e-05	48	16	4	HP:0000902
MousePheno	abnormal craniofacial morphology	TRAF3IP2 TMEM131 DLX2 WDFY3 RERE SIK3 PTCH1 DCAF5 EP300 BRD4 RAD9A SEC24B	5.35e-05	1372	34	12	MP:0000428
MousePheno	craniofacial phenotype	TRAF3IP2 TMEM131 DLX2 WDFY3 RERE SIK3 PTCH1 DCAF5 EP300 BRD4 RAD9A SEC24B	5.35e-05	1372	34	12	MP:0005382
MousePheno	intrahepatic cholestasis	SIK3 ATXN2	5.72e-05	5	34	2	MP:0005415
MousePheno	absent palatal shelf	DLX2 PTCH1	5.72e-05	5	34	2	MP:0009882
Domain	Distal-less_N	DLX2 DLX3	1.55e-05	3	43	2	IPR022135
Domain	DLL_N	DLX2 DLX3	1.55e-05	3	43	2	PF12413
Domain	Nlgn	NLGN2 NLGN1	5.15e-05	5	43	2	IPR000460
Domain	-	AHRR ATOH1 HELT HES7	1.14e-04	109	43	4	4.10.280.10
Domain	HLH	AHRR ATOH1 HELT HES7	1.22e-04	111	43	4	PF00010
Domain	HLH	AHRR ATOH1 HELT HES7	1.45e-04	116	43	4	SM00353
Domain	BHLH	AHRR ATOH1 HELT HES7	1.49e-04	117	43	4	PS50888
Domain	bHLH_dom	AHRR ATOH1 HELT HES7	1.54e-04	118	43	4	IPR011598
Domain	PTBI	FRS3 IRS1	2.81e-04	11	43	2	SM00310
Domain	IRS_PTB	FRS3 IRS1	3.37e-04	12	43	2	PS51064
Domain	Hairy_orange	HELT HES7	3.37e-04	12	43	2	PF07527
Domain	Orange_dom	HELT HES7	3.37e-04	12	43	2	IPR003650
Domain	Carboxylesterase_B_CS	NLGN2 NLGN1	3.97e-04	13	43	2	IPR019819
Domain	ORANGE	HELT HES7	3.97e-04	13	43	2	PS51054
Domain	IRS_PTB	FRS3 IRS1	4.63e-04	14	43	2	IPR002404
Domain	COesterase	NLGN2 NLGN1	4.63e-04	14	43	2	PF00135
Domain	CARBOXYLESTERASE_B_2	NLGN2 NLGN1	4.63e-04	14	43	2	PS00941
Domain	CarbesteraseB	NLGN2 NLGN1	4.63e-04	14	43	2	IPR002018
Domain	IRS	FRS3 IRS1	4.63e-04	14	43	2	PF02174
Domain	HTH_motif	DLX2 DLX3 EN2	5.36e-04	69	43	3	IPR000047
Domain	Homeobox_metazoa	DLX2 DLX3 EN2	1.16e-03	90	43	3	IPR020479
Domain	G_patch	GPATCH8 CHERP	1.27e-03	23	43	2	SM00443
Domain	G_patch_dom	GPATCH8 CHERP	1.27e-03	23	43	2	IPR000467
Domain	G-patch	GPATCH8 CHERP	1.27e-03	23	43	2	PF01585
Domain	G_PATCH	GPATCH8 CHERP	1.27e-03	23	43	2	PS50174
Domain	Bromodomain_CS	EP300 BRD4	1.62e-03	26	43	2	IPR018359
Domain	PH_dom-like	FRS3 IRS1 WDFY3 PLEKHA6 PHLDA1	2.84e-03	426	43	5	IPR011993
Domain	BROMODOMAIN_1	EP300 BRD4	3.28e-03	37	43	2	PS00633
Domain	Bromodomain	EP300 BRD4	3.45e-03	38	43	2	PF00439
Domain	BROMODOMAIN_2	EP300 BRD4	4.01e-03	41	43	2	PS50014
Domain	BROMO	EP300 BRD4	4.20e-03	42	43	2	SM00297
Domain	Bromodomain	EP300 BRD4	4.20e-03	42	43	2	IPR001487
Domain	-	EP300 BRD4	4.20e-03	42	43	2	1.20.920.10
Domain	TF_fork_head_CS_2	FOXD3 FOXJ3	5.03e-03	46	43	2	IPR030456
Domain	TF_fork_head_CS_1	FOXD3 FOXJ3	5.24e-03	47	43	2	IPR018122
Domain	FORK_HEAD_3	FOXD3 FOXJ3	5.69e-03	49	43	2	PS50039
Domain	FH	FOXD3 FOXJ3	5.69e-03	49	43	2	SM00339
Domain	FORK_HEAD_1	FOXD3 FOXJ3	5.69e-03	49	43	2	PS00657
Domain	FORK_HEAD_2	FOXD3 FOXJ3	5.69e-03	49	43	2	PS00658
Domain	Forkhead	FOXD3 FOXJ3	5.69e-03	49	43	2	PF00250
Domain	Fork_head_dom	FOXD3 FOXJ3	5.69e-03	49	43	2	IPR001766
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	IRS1 STIM2 RERE SIK3 CHERP PHLDA1 ATXN2 MAP4K4 DCAF5 EP300 BRD4 CPEB4 SEC24B	1.25e-08	1451	43	13	30550785
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	TMEM131 STIM2 ATXN2 MAP4K4 CPEB4 SEC24B NFX1	3.33e-08	263	43	7	34702444
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD3 DLX2 DLX3 RERE ATOH1 EN2 FOXJ3 HELT HES7 NFX1	1.23e-07	908	43	10	19274049
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN2 NLGN1 EN2	6.35e-07	14	43	3	23226954
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	FOXD3 DLX2 DLX3 ATOH1 PTCH1 FOXJ3	6.49e-07	251	43	6	29031500
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	WDFY3 RERE SIK3 PHLDA1 DIS3L DCAF5 EP300 BRD4 GRAP2 CPEB4	8.13e-07	1116	43	10	31753913
Pubmed	Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.	NLGN2 NLGN1	1.49e-06	2	43	2	10892652
Pubmed	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.	ATOH1 BRD4	1.49e-06	2	43	2	31292434
Pubmed	NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.	NLGN2 NLGN1	1.49e-06	2	43	2	29278843
Pubmed	Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression.	ATOH1 PTCH1	1.49e-06	2	43	2	38834071
Pubmed	A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.	ATOH1 PTCH1	1.49e-06	2	43	2	24141309
Pubmed	Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.	ATOH1 PTCH1	1.49e-06	2	43	2	30695697
Pubmed	Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.	NLGN2 NLGN1	1.49e-06	2	43	2	19889999
Pubmed	Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.	ATOH1 PTCH1 EN2	3.50e-06	24	43	3	24946904
Pubmed	β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus.	DLX2 PTCH1 HELT	3.97e-06	25	43	3	22745311
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXD3 DLX2 DLX3 ATOH1 EN2 FOXJ3 HES7	4.36e-06	544	43	7	28473536
Pubmed	Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.	NLGN2 NLGN1	4.48e-06	3	43	2	22960622
Pubmed	Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.	NLGN2 NLGN1	4.48e-06	3	43	2	28607166
Pubmed	Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.	EP300 BRD4	4.48e-06	3	43	2	32544088
Pubmed	Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.	NLGN2 NLGN1	4.48e-06	3	43	2	27217145
Pubmed	Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.	EP300 BRD4	4.48e-06	3	43	2	20676058
Pubmed	Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.	EP300 BRD4	4.48e-06	3	43	2	28262505
Pubmed	Conditional loss of Engrailed1/2 in Atoh1-derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice.	ATOH1 EN2	4.48e-06	3	43	2	35044072
Pubmed	Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.	NLGN2 NLGN1	4.48e-06	3	43	2	29100073
Pubmed	Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain.	DLX2 DLX3	4.48e-06	3	43	2	1687503
Pubmed	Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.	NLGN2 NLGN1	4.48e-06	3	43	2	27473321
Pubmed	Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.	NLGN2 NLGN1	4.48e-06	3	43	2	26291161
Pubmed	Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development.	DLX2 DLX3	4.48e-06	3	43	2	7893603
Pubmed	Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses.	NLGN2 NLGN1	4.48e-06	3	43	2	17897391
Pubmed	Neuroligins determine synapse maturation and function.	NLGN2 NLGN1	4.48e-06	3	43	2	16982420
Pubmed	Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.	EP300 BRD4	4.48e-06	3	43	2	24945803
Pubmed	Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.	NLGN2 NLGN1	4.48e-06	3	43	2	17582332
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	DLX2 PTCH1 EN2 ATXN2 EP300 NFX1	5.04e-06	358	43	6	32460013
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DLX2 NLGN2 IRS1 WDFY3 PTCH1 EP300 BRD4 RAD9A NFX1	6.81e-06	1105	43	9	35748872
Pubmed	Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1.	EP300 BRD4	8.94e-06	4	43	2	30428346
Pubmed	Autism-related deficits via dysregulated eIF4E-dependent translational control.	NLGN2 NLGN1	8.94e-06	4	43	2	23172145
Pubmed	Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern.	ATOH1 EN2	8.94e-06	4	43	2	27609139
Pubmed	Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.	PTCH1 BRD4	8.94e-06	4	43	2	24973920
Pubmed	NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.	EP300 BRD4	8.94e-06	4	43	2	24875858
Pubmed	Functional architecture of atrophins.	RERE EP300	8.94e-06	4	43	2	17150957
Pubmed	Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.	EP300 BRD4	8.94e-06	4	43	2	35716662
Pubmed	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry.	NLGN2 NLGN1	8.94e-06	4	43	2	32719346
Pubmed	Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.	NLGN2 NLGN1	8.94e-06	4	43	2	30056576
Pubmed	Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.	ATOH1 PTCH1	8.94e-06	4	43	2	19185848
Pubmed	Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.	ATOH1 PTCH1	8.94e-06	4	43	2	33082319
Pubmed	ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.	DLX2 DLX3 PTCH1	1.12e-05	35	43	3	28069742
Pubmed	The evolution of the vertebrate Dlx gene family.	DLX2 DLX3	1.49e-05	5	43	2	8855272
Pubmed	Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.	NLGN2 NLGN1	1.49e-05	5	43	2	23358245
Pubmed	5-HT modulation of a medial septal circuit tunes social memory stability.	NLGN2 NLGN1	1.49e-05	5	43	2	34616037
Pubmed	Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.	NLGN2 NLGN1	1.49e-05	5	43	2	27581450
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN2 NLGN1	1.49e-05	5	43	2	15620359
Pubmed	Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures.	NLGN2 NLGN1	1.49e-05	5	43	2	28939043
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN2 NLGN1	1.49e-05	5	43	2	10996085
Pubmed	Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.	DLX2 DLX3	1.49e-05	5	43	2	9187081
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN2 NLGN1	1.49e-05	5	43	2	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN2 NLGN1	2.23e-05	6	43	2	21838267
Pubmed	Expression of Dlx genes during the development of the murine dentition.	DLX2 DLX3	2.23e-05	6	43	2	11180832
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN2 NLGN1	2.23e-05	6	43	2	29724786
Pubmed	Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.	DLX2 DLX3	2.23e-05	6	43	2	11069141
Pubmed	Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.	NLGN2 NLGN1	2.23e-05	6	43	2	29742426
Pubmed	Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.	NLGN2 NLGN1	2.23e-05	6	43	2	19816407
Pubmed	Structures, alternative splicing, and neurexin binding of multiple neuroligins.	NLGN2 NLGN1	2.23e-05	6	43	2	8576240
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	CHERP ATXN2	2.23e-05	6	43	2	8896557
Pubmed	FoxJ3, a novel mammalian forkhead gene expressed in neuroectoderm, neural crest, and myotome.	FOXD3 FOXJ3	2.23e-05	6	43	2	15366017
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AHRR NLGN2 STIM2 PLEKHA6 DIS3L CPEB4	3.08e-05	493	43	6	15368895
Pubmed	Expression pattern of Dlx3 during cell differentiation in mineralized tissues.	DLX2 DLX3	3.12e-05	7	43	2	16172034
Pubmed	Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.	PTCH1 BRD4	3.12e-05	7	43	2	31594641
Pubmed	Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.	DLX2 DLX3	3.12e-05	7	43	2	17164413
Pubmed	Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit.	ATOH1 PTCH1	3.12e-05	7	43	2	32183943
Pubmed	A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse.	HELT HES7	3.12e-05	7	43	2	19306043
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	FOXJ3 CCNK EP300 FAM222B	3.79e-05	152	43	4	38360978
Pubmed	Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.	DLX2 DLX3	4.16e-05	8	43	2	11358480
Pubmed	Roles for Msx and Dlx homeoproteins in vertebrate development.	DLX2 DLX3	4.16e-05	8	43	2	10773441
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN2 NLGN1	4.16e-05	8	43	2	30871858
Pubmed	Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma.	ATOH1 PTCH1	4.16e-05	8	43	2	20418906
Pubmed	The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.	EP300 BRD4	4.16e-05	8	43	2	23752591
Pubmed	Control of excitatory and inhibitory synapse formation by neuroligins.	NLGN2 NLGN1	4.16e-05	8	43	2	15681343
Pubmed	Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.	EP300 SEC24B	4.16e-05	8	43	2	27018634
Pubmed	Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum.	ATOH1 PTCH1	4.16e-05	8	43	2	15183722
Pubmed	Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.	ATOH1 PTCH1	4.16e-05	8	43	2	31983537
Pubmed	Some distal limb structures develop in mice lacking Sonic hedgehog signaling.	DLX2 PTCH1	5.35e-05	9	43	2	11118883
Pubmed	Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.	DLX2 PTCH1	5.35e-05	9	43	2	9428417
Pubmed	Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.	SHFL DBF4B	5.35e-05	9	43	2	32290274
Pubmed	Molecular self-avoidance in synaptic neurexin complexes.	NLGN2 NLGN1	5.35e-05	9	43	2	34919427
Pubmed	Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.	ATOH1 PTCH1	5.35e-05	9	43	2	31851932
Pubmed	Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling.	DLX2 PTCH1	5.35e-05	9	43	2	12397105
Pubmed	Patched2 modulates tumorigenesis in patched1 heterozygous mice.	ATOH1 PTCH1	5.35e-05	9	43	2	16849540
Pubmed	Binding of neuroligins to PSD-95.	NLGN2 NLGN1	5.35e-05	9	43	2	9278515
Pubmed	Dlx and other homeobox genes in the morphological development of the dentition.	DLX2 DLX3	6.68e-05	10	43	2	7554933
Pubmed	An endothelin-1 switch specifies maxillomandibular identity.	DLX2 DLX3	6.68e-05	10	43	2	19017795
Pubmed	Distal-less and other homeobox genes in the development of the dentition.	DLX2 DLX3	6.68e-05	10	43	2	7964557
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	ATXN2 MAP4K4 SEC24B NFX1	7.63e-05	182	43	4	32239614
Pubmed	Pleiotropic role for MYCN in medulloblastoma.	ATOH1 PTCH1	8.15e-05	11	43	2	20478998
Pubmed	Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation.	ATOH1 PTCH1	8.15e-05	11	43	2	36252002
Pubmed	Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.	FOXD3 ATOH1	8.15e-05	11	43	2	15788454
Pubmed	Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.	DLX2 PTCH1	8.15e-05	11	43	2	24949938
Pubmed	Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw.	DLX2 DLX3	8.15e-05	11	43	2	20333701
Pubmed	Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.	ATOH1 PTCH1	8.15e-05	11	43	2	29139542
Pubmed	Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice.	DLX2 DLX3	8.15e-05	11	43	2	10625532
Pubmed	Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.	DLX2 DLX3	8.15e-05	11	43	2	22902530
Interaction	ALG13 interactions	WDFY3 RERE GPATCH8 ATXN2 CCNK EP300 CPEB4	9.36e-08	183	42	7	int:ALG13
Interaction	KRTAP4-12 interactions	RERE PHLDA1 SHFL CCNK DBF4B GRAP2	9.79e-07	161	42	6	int:KRTAP4-12
Interaction	CFD interactions	IRS1 STIM2 RERE SIK3 CHERP PHLDA1 ATXN2 MAP4K4 DCAF5 EP300 BRD4 CPEB4 SEC24B	2.29e-06	1360	42	13	int:CFD
Interaction	FNDC5 interactions	IRS1 STIM2 RERE SIK3 CHERP PHLDA1 ATXN2 MAP4K4 DCAF5 EP300 BRD4 CPEB4 SEC24B	5.41e-06	1470	42	13	int:FNDC5
Interaction	RACK1 interactions	TMEM131 IRS1 SIK3 CHERP ATXN2 EP300 BRD4 GRAP2 NFX1	1.17e-05	704	42	9	int:RACK1
Interaction	MKRN2 interactions	DLX2 PTCH1 EN2 ATXN2 EP300 CPEB4 NFX1	1.33e-05	385	42	7	int:MKRN2
Interaction	RNF43 interactions	TMEM131 STIM2 ATXN2 MAP4K4 CPEB4 SEC24B NFX1	2.59e-05	427	42	7	int:RNF43
Interaction	TOP3B interactions	DLX2 NLGN2 IRS1 WDFY3 PTCH1 ATXN2 EP300 BRD4 CPEB4 RAD9A SEC24B NFX1	3.06e-05	1470	42	12	int:TOP3B
Interaction	KRTAP6-2 interactions	FRS3 RERE PHLDA1 CCNK HELT	4.20e-05	187	42	5	int:KRTAP6-2
Interaction	BMI1 interactions	GPATCH8 CHERP ATXN2 EP300 BRD4 CPEB4 SEC24B NFX1	5.53e-05	659	42	8	int:BMI1
Interaction	ZRANB2 interactions	PTCH1 MAP4K4 EP300 BRD4 NFX1	5.64e-05	199	42	5	int:ZRANB2
Interaction	TRIP6 interactions	FRS3 TRAF3IP2 RERE SIK3 SHFL FAM222B	9.21e-05	358	42	6	int:TRIP6
Interaction	RTRAF interactions	ATXN2 EP300 BRD4 CPEB4 NFX1	9.46e-05	222	42	5	int:RTRAF
Interaction	CNOT9 interactions	TMEM131 ATXN2 MAP4K4 DIS3L CPEB4	1.14e-04	231	42	5	int:CNOT9
Interaction	KHDRBS1 interactions	IRS1 PTCH1 ATXN2 EP300 BRD4 GRAP2	1.15e-04	373	42	6	int:KHDRBS1
Interaction	TLE3 interactions	TRAF3IP2 RERE GPATCH8 CHERP EP300 BRD4	1.21e-04	376	42	6	int:TLE3
Interaction	EYA4 interactions	FOXJ3 CCNK EP300 FAM222B SEC24B	1.45e-04	243	42	5	int:EYA4
Interaction	PRRC2A interactions	RERE PTCH1 ATXN2 BRD4 CPEB4 NFX1	1.45e-04	389	42	6	int:PRRC2A
Interaction	SEMA4B interactions	NLGN2 NLGN1 PTCH1	1.45e-04	49	42	3	int:SEMA4B
Interaction	DNMT1 interactions	DCAF5 EP300 BRD4 RAD9A NFX1	1.78e-04	254	42	5	int:DNMT1
Cytoband	19p13.1	CHERP BRD4	9.40e-04	48	43	2	19p13.1
Cytoband	22q13.2	EP300 GRAP2	1.47e-03	60	43	2	22q13.2
Cytoband	17q21	DLX3 DBF4B	1.61e-03	63	43	2	17q21
Cytoband	17q21.31	GPATCH8 DBF4B	2.71e-03	82	43	2	17q21.31
Cytoband	7q22.1	KMT2E NYAP1	5.08e-03	113	43	2	7q22.1
Cytoband	17p13.1	NLGN2 HES7	5.52e-03	118	43	2	17p13.1
GeneFamily	Basic helix-loop-helix proteins	AHRR ATOH1 HELT HES7	2.74e-05	110	29	4	420
GeneFamily	NKL subclass homeoboxes and pseudogenes	DLX2 DLX3 EN2	1.66e-04	67	29	3	519
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	GPATCH8 CHERP	5.63e-04	22	29	2	579
GeneFamily	Forkhead boxes	FOXD3 FOXJ3	2.15e-03	43	29	2	508
GeneFamily	PHD finger proteins	KMT2E NFX1	9.12e-03	90	29	2	88
Coexpression	GSE17721_PAM3CSK4_VS_CPG_0.5H_BMDC_UP	TMEM131 CHERP ATXN2 MAP4K4 SHFL CCNK	8.82e-07	200	43	6	M3850
Coexpression	GSE17721_LPS_VS_CPG_12H_BMDC_UP	GPATCH8 FOXJ3 DCAF5 BRD4 SEC24B	1.83e-05	199	43	5	M4005
Coexpression	GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_20H_UP	TMEM131 IRS1 KMT2E ATXN2 RAD9A	1.87e-05	200	43	5	M9646
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TMEM131 IRS1 WDFY3 SIK3 GPATCH8 ATXN2 FOXJ3 SEC24B	6.59e-05	856	43	8	M4500
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	STIM2 SIK3 GPATCH8 KMT2E PHLDA1 FOXJ3 SHFL DCAF5 EP300 GRAP2	1.18e-04	1492	43	10	M40023
Coexpression	GSE21033_1H_VS_24H_POLYIC_STIM_DC_UP	TMEM131 KMT2E BRD4 SEC24B	1.40e-04	161	43	4	M7728
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	IRS1 STIM2 NLGN1 WDFY3 RERE MAP4K4 DIS3L DCAF5	2.05e-04	1009	43	8	M157
Coexpression	JOHNSTONE_PARVB_TARGETS_2_DN	AHRR IRS1 FOXJ3 SEC24B NFX1	2.42e-04	344	43	5	M2239
Coexpression	GSE3982_MAC_VS_BCELL_DN	TMEM131 RERE GPATCH8 NFX1	3.04e-04	197	43	4	M5495
Coexpression	GSE21360_PRIMARY_VS_SECONDARY_MEMORY_CD8_TCELL_DN	FOXD3 ADGRD2 SHFL BRD4	3.10e-04	198	43	4	M7620
Coexpression	GSE41867_DAY15_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_UP	UBALD2 RERE SIK3 SHFL	3.16e-04	199	43	4	M9452
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_DN	TMEM131 PHLDA1 GRAP2 CPEB4	3.16e-04	199	43	4	M4558
Coexpression	GSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_MAC_DN	RERE PTCH1 ATXN2 FOXJ3	3.16e-04	199	43	4	M5240
Coexpression	GSE31082_DN_VS_DP_THYMOCYTE_DN	UBALD2 STIM2 KMT2E EP300	3.22e-04	200	43	4	M5055
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_UP	RERE DCAF5 EP300 BRD4	3.22e-04	200	43	4	M9458
Coexpression	GSE17721_LPS_VS_CPG_24H_BMDC_DN	TMEM131 DLX3 WDFY3 BRD4	3.22e-04	200	43	4	M4011
Coexpression	GSE17721_CPG_VS_GARDIQUIMOD_0.5H_BMDC_DN	TMEM131 EN2 MAP4K4 CCNK	3.22e-04	200	43	4	M3877
Coexpression	GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_DN	STIM2 NLGN1 PLEKHA6 CPEB4	3.22e-04	200	43	4	M7353
Coexpression	GSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN	FRS3 DLX2 SHFL CCNK	3.22e-04	200	43	4	M9588
Coexpression	GSE23505_IL6_IL1_VS_IL6_IL1_IL23_TREATED_CD4_TCELL_DN	RERE ATXN2 FOXJ3 DCAF5	3.22e-04	200	43	4	M7859
Coexpression	GSE21670_TGFB_VS_IL6_TREATED_CD4_TCELL_UP	FRS3 DLX2 ATOH1 MAP4K4	3.22e-04	200	43	4	M7437
Coexpression	GSE27786_LSK_VS_CD8_TCELL_DN	UBALD2 DLX3 PTCH1 CPEB4	3.22e-04	200	43	4	M4750
Coexpression	GSE24210_RESTING_TREG_VS_TCONV_UP	TRAF3IP2 STIM2 EP300 CPEB4	3.22e-04	200	43	4	M7839
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	WDFY3 SIK3 GPATCH8 FOXJ3 EP300 BRD4 SEC24B	3.50e-04	822	43	7	M6782
Coexpression	CHANDRAN_METASTASIS_UP	KMT2E ATXN2 MAP4K4 CPEB4	3.80e-04	209	43	4	M16036
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	FRS3 STIM2 NLGN1 PLEKHA6 SIK3 KMT2E EN2 CPEB4	3.81e-04	1106	43	8	M39071
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	NLGN2 IRS1 NLGN1 PTCH1	2.89e-05	183	43	4	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UBALD2 SIK3 KMT2E MAP4K4	3.01e-05	185	43	4	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	RERE GPATCH8 ATXN2 MAP4K4	3.08e-05	186	43	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RERE GPATCH8 ATXN2 MAP4K4	3.08e-05	186	43	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AHRR IRS1 NLGN1 PTCH1	3.34e-05	190	43	4	591310e615700321a010a4b90405cbbbbdb3aade
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	RERE KMT2E ATXN2 MAP4K4	3.55e-05	193	43	4	e6a688bc834f845ff64dae1be64f073eec5091a1
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	TRAF3IP2 IRS1 WDFY3 PHLDA1 EP300	1.87e-05	174	43	5	1659_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA	TRAF3IP2 IRS1 WDFY3 PHLDA1 EP300	1.92e-05	175	43	5	1058_DN
Drug	1,4-diaminocyclohexane	PTCH1 BRD4	2.09e-05	4	43	2	ctd:C088969
Drug	Methotrexate [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A	DLX2 NLGN1 PHLDA1 EP300 BRD4	2.86e-05	190	43	5	6318_DN
Drug	cis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Up 200; 100uM; MCF7; HT_HG-U133A_EA	NLGN1 SIK3 FOXJ3 SHFL NFX1	3.08e-05	193	43	5	881_UP
Drug	ikarugamycin; Up 200; 2uM; MCF7; HT_HG-U133A_EA	DLX2 NLGN1 WDFY3 PHLDA1 NFX1	3.24e-05	195	43	5	866_UP
Drug	5255229; Up 200; 13uM; MCF7; HT_HG-U133A_EA	DLX2 NLGN1 GPATCH8 PHLDA1 NFX1	3.32e-05	196	43	5	833_UP
Drug	Pirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	FRS3 DLX2 RERE PTCH1 NFX1	3.40e-05	197	43	5	5274_UP
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	FRS3 WDFY3 PHLDA1 FOXJ3 DBF4B	3.56e-05	199	43	5	5781_DN
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	FRS3 TRAF3IP2 ATXN2 DBF4B NFX1	3.56e-05	199	43	5	3684_DN
Disease	Childhood Medulloblastoma	ATOH1 PTCH1 BRD4	3.42e-05	43	43	3	C0278510
Disease	Melanotic medulloblastoma	ATOH1 PTCH1 BRD4	3.42e-05	43	43	3	C1275668
Disease	Medullomyoblastoma	ATOH1 PTCH1 BRD4	3.42e-05	43	43	3	C0205833
Disease	Desmoplastic Medulloblastoma	ATOH1 PTCH1 BRD4	3.42e-05	43	43	3	C0751291
Disease	Adult Medulloblastoma	ATOH1 PTCH1 BRD4	3.42e-05	43	43	3	C0278876
Disease	autoantibody measurement	STIM2 DCAF5	4.34e-05	7	43	2	EFO_0004866
Disease	Medulloblastoma	ATOH1 PTCH1 BRD4	5.39e-05	50	43	3	C0025149
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN2 NLGN1 WDFY3 EN2	7.14e-05	152	43	4	DOID:0060041 (implicated_via_orthology)
Disease	reticulocyte measurement	TMEM131 IRS1 ADGRD2 NYAP1 ATXN2 BRD4 HES7 CPEB4	1.22e-04	1053	43	8	EFO_0010700
Disease	triacylglycerol 54:6 measurement	NLGN1 SIK3	4.70e-04	22	43	2	EFO_0010424
Disease	Headache, type 2 diabetes mellitus	NLGN1 DCAF5	5.15e-04	23	43	2	HP_0002315, MONDO_0005148
Disease	triacylglycerol 56:4 measurement	NLGN1 SIK3	5.61e-04	24	43	2	EFO_0010431
Disease	Autistic Disorder	DLX2 NLGN1 KMT2E EN2	5.63e-04	261	43	4	C0004352
Disease	mean platelet volume	IRS1 SIK3 ATXN2 DIS3L DCAF5 GRAP2 CPEB4	6.27e-04	1020	43	7	EFO_0004584
Disease	obsolete_red blood cell distribution width	AHRR ADGRD2 SIK3 EP300 FAM222B BRD4 CPEB4 RAD9A	6.43e-04	1347	43	8	EFO_0005192
Disease	allergic rhinitis	RERE SIK3 ATXN2	9.68e-04	133	43	3	EFO_0005854
Disease	triacylglycerol 52:5 measurement	NLGN1 SIK3	1.20e-03	35	43	2	EFO_0010417
Disease	eosinophil count	TMEM131 RERE SIK3 CHERP ATXN2 MAP4K4 GRAP2 CPEB4	1.23e-03	1488	43	8	EFO_0004842
Disease	triacylglycerol 52:4 measurement	NLGN1 SIK3	1.27e-03	36	43	2	EFO_0010416
Disease	blood molybdenum measurement	PTCH1 ATXN2	1.41e-03	38	43	2	EFO_0007582
Disease	Craniofacial Abnormalities	DLX2 PTCH1 EP300	1.53e-03	156	43	3	C0376634
Disease	autistic disorder (is_implicated_in)	KMT2E EN2	1.72e-03	42	43	2	DOID:12849 (is_implicated_in)
Disease	systemic lupus erythematosus (implicated_via_orthology)	TRAF3IP2 EP300	1.80e-03	43	43	2	DOID:9074 (implicated_via_orthology)
Disease	spleen volume	PLEKHA6 ATXN2	1.80e-03	43	43	2	EFO_0600047
Disease	lung adenocarcinoma (is_implicated_in)	PTCH1 MAP4K4	2.34e-03	49	43	2	DOID:3910 (is_implicated_in)
Disease	white matter microstructure measurement	WDFY3 CHERP PTCH1 ATXN2	2.47e-03	390	43	4	EFO_0005674

Protein segments in the cluster

Peptide	Gene	Start	Entry
HPPLCHFPQRSLQHQ	AHRR	481	A9YTQ3
HIHCPQLPQPALHQN	EP300	816	Q09472
QPPEHSTPPHLNQHA	BRD4	841	O60885
PHHTPHQLQQPPSLQ	CCNK	266	O75909
TAPLLHPTQTPQPHH	DLX2	296	Q07687
HLQQQPPQPATLHHA	DLX3	261	O60479
HQPVPQLQAHSTPHP	RAD9A	281	Q99638
HDHRRPHPQHSQQPP	MAP4K4	526	O95819
AHPNALNLHTPQHPP	HELT	226	A6NFD8
PNATLHPHTPHPQPS	ATXN2	1136	Q99700
HPHPQPLAQVHHIPQ	GPATCH8	1396	Q9UKJ3
PQALAHQGLQHPHNP	FAM222B	211	Q8WU58
NHNNGRLHPRPPHPH	DCAF5	831	Q96JK2
RLHPRPPHPHNNGQN	DCAF5	836	Q96JK2
PPIPHHRHQSDKNPG	NFX1	1086	Q12986
PGPHLVQQPNSHQQH	KMT2E	1636	Q8IZD2
TGGQNNTLPHPHPHP	NLGN1	841	Q8N2Q7
EPSLPHPHHQVLQPH	IRS1	826	P35568
FPPHQQHPQFNQPPH	CHERP	526	Q8IWX8
TLHPHQPSHPRAASP	DBF4B	371	Q8NFT6
RSPHPAPHPQQHSQL	FOXJ3	396	Q9UPW0
APHPQQHSQLQSPHP	FOXJ3	401	Q9UPW0
QHSQLQSPHPQHPSP	FOXJ3	406	Q9UPW0
QSPHPQHPSPHQHIQ	FOXJ3	411	Q9UPW0
PSLHDPPHHNNNNEA	FRS3	261	O43559
PHQALLRQHPPPHQE	DIS3L	701	Q8TF46
LGDHHRQPQPHHLPQ	ATOH1	16	Q92858
PHLQPPHHHQNATPS	CPEB4	26	Q17RY0
PAVLQAPGNHQHPHR	EN2	51	P19622
LSDHPPTLPLQQHQH	GRAP2	186	O75791
PALHQRPPVHQGHPS	HES7	156	Q9BYE0
HPSPLPPLPSQQHHQ	SEC24B	236	O95487
PPTATSHNNTLPHPH	NLGN2	816	Q8NFZ4
PHHGQPQPPHQQPLT	FOXD3	66	Q9UJU5
TSPPQQPHALPPHAH	NYAP1	286	Q6ZVC0
HPESRHHPPSNPRQQ	PTCH1	1271	Q13635
HHPPSNPRQQPHLDS	PTCH1	1276	Q13635
RIQPSSPPPNHPNNH	SIK3	726	Q9Y2K2
SPPPNHPNNHLFRQP	SIK3	731	Q9Y2K2
PHTHIQQAPALHPQR	RERE	796	Q9P2R6
HLQHRAQSPLFPPHP	ADGRD2	591	Q7Z7M1
LPRHQDQPHHQPPNR	TRAF3IP2	346	O43734
QNHLPKVLHPSNPHI	SHFL	231	Q9NUL5
SENVPPSKHHQQPPH	PLEKHA6	181	Q9Y2H5
TRAHLQGPLSHPHPN	WDFY3	3356	Q8IZQ1
PQRAQLAPHAPHPSH	STIM2	526	Q9P246
QIPHPHPQPHSQPHG	PHLDA1	376	Q8WV24
QHHAHSPLEQHPQPP	TMEM131	1291	Q92545
PPSSPTTFHHLHRPQ	UBALD2	126	Q8IYN6