Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of neurotransmitter secretion

SYT4 SYT11 ASIC1

6.07e-079413GO:0046929
GeneOntologyBiologicalProcessnegative regulation of neurotransmitter transport

SYT4 SYT11 ASIC1

2.61e-0614413GO:0051589
GeneOntologyBiologicalProcessnegative regulation of microglial cell activation

PTPRC SYT11

1.07e-048412GO:1903979
GeneOntologyBiologicalProcesscell-substrate junction disassembly

STON1 MAP4K4

1.38e-049412GO:0120180
GeneOntologyBiologicalProcessfocal adhesion disassembly

STON1 MAP4K4

1.38e-049412GO:0120181
DomainSH2

LCP2 SUPT6H TNS3 SOCS4

5.73e-05101394PF00017
DomainSH2

LCP2 SUPT6H TNS3 SOCS4

7.99e-05110394SM00252
DomainSH2

LCP2 SUPT6H TNS3 SOCS4

8.28e-05111394PS50001
DomainSH2

LCP2 SUPT6H TNS3 SOCS4

8.57e-05112394IPR000980
Domain-

LCP2 SUPT6H TNS3 SOCS4

8.57e-051123943.30.505.10
Domain-

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

4.54e-046793973.30.160.60
Domainzf-C2H2

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

5.13e-04693397PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

5.17e-04694397IPR013087
DomainSynaptotagmin

SYT4 SYT11

7.88e-0420392IPR001565
DomainZINC_FINGER_C2H2_2

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

9.93e-04775397PS50157
DomainZINC_FINGER_C2H2_1

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

1.01e-03777397PS00028
DomainZnf_C2H2-like

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

1.16e-03796397IPR015880
DomainZnf_C2H2

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

1.24e-03805397IPR007087
DomainZnF_C2H2

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

1.27e-03808397SM00355
DomainC2_dom

SYT4 SYT11 TNS3

4.82e-03164393IPR000008
DomainPTPc_motif

PTPRC TNS3

6.74e-0359392SM00404
DomainTyr_Pase_cat

PTPRC TNS3

6.74e-0359392IPR003595
DomainRNaseH-like_dom

SUPT6H POLE

9.13e-0369392IPR012337
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF721 ZNF43 ZNF254

6.85e-071541315885501
Pubmed

Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase.

PTPRC LCP2

4.06e-0634128703037
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF721 ZNF43 ZNF254

5.44e-062941314563677
Pubmed

Strain distribution pattern for SSLP markers in the SWXJ recombinant inbred strain set: chromosomes 1 to 6.

C5 PTPRC

2.84e-0574128747926
Pubmed

Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.

SYT4 SYT11

4.86e-05941210531343
Pubmed

EphB6-null mutation results in compromised T cell function.

PTPRC LCP2

4.86e-05941215599401
Pubmed

Real-time resolution of point mutations that cause phenovariance in mice.

PTPRC MAP4K4

6.07e-051041225605905
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF721 ZNF43

6.07e-051041218588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF721 ZNF43

7.41e-051141215469996
Pubmed

SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.

SYT4 SYT11

7.41e-051141210734137
Pubmed

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.

PTPRC SPTBN1

7.41e-051141224337748
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

LCP2 SUPT6H TNS3

1.05e-047741322973453
Pubmed

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.

POLE SMC1B

1.05e-041341229754823
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF721 ZNF43

1.05e-041341219850934
Pubmed

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

SPTBN1 MKS1

1.61e-041641223870131
Pubmed

Genetic mapping of five mouse genes encoding synaptotagmins.

SYT4 PTPRC

2.29e-04194128747928
Pubmed

A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.

C5 PTPRC

2.81e-04214124042679
Pubmed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

TTC9 TNS3

3.38e-042341225217961
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

PHF1 SALL4 ZNF721 GTF3A ZNF43 ZNF254

3.47e-0480841620412781
Pubmed

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

MAP4K4 SUPT6H

5.03e-042841224462114
Pubmed

The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.

C5 PTPRC

7.43e-04344121686571
Pubmed

α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

MAP4K4 SPTBN1

7.87e-043541237381005
Pubmed

Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.

ZBTB18 ERLEC1

8.33e-043641224035498
Pubmed

Genetic composition of the recombinant congenic strains.

C5 PTPRC

1.08e-03414128903730
CytobandEnsembl 112 genes in cytogenetic band chr2p16

STON1 ERLEC1 SPTBN1

1.90e-04121423chr2p16
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF675 ZNF43 ZNF254

1.95e-04122423chr19p12
Cytoband12q12

GXYLT1 ASIC1

8.60e-044742212q12
Cytoband19p12

ZNF675 ZNF254

3.11e-039042219p12
GeneFamilySH2 domain containing

LCP2 SUPT6H TNS3 SOCS4

2.57e-05101314741
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF675 SALL4 ZNF721 GTF3A ZBTB18 ZNF43 ZNF254

1.73e-0471831728
GeneFamilySynaptotagmins

SYT4 SYT11

3.81e-0417312765
Diseasebeta-Ala-His dipeptidase measurement

ZNF675 ZNF254

4.74e-058392EFO_0008033
DiseaseCleft palate, cleft lip

PHF1 SALL4 STON1 DPCD

4.96e-04279394EFO_0003959, HP_0000175
Diseaseprimary immunodeficiency disease (is_implicated_in)

PTPRC LCP2

1.42e-0342392DOID:612 (is_implicated_in)
Diseasecoronary artery disease

PHF1 C5 STON1 MRPL22 TNS3 ZNF722

4.50e-031194396EFO_0001645
Diseasered blood cell density measurement

PTPRC STON1 MRPL22 TNS3 SPTBN1

5.80e-03880395EFO_0007978
Diseaseorofacial cleft, sex interaction measurement

GALR1 TNS3

5.80e-0386392EFO_0008343, MONDO_0000358

Protein segments in the cluster

PeptideGeneStartEntry
VYYGRKRIAKKKTHV

SYT11

336

Q9BT88
YVIMTTAHKEKYKCI

ERLEC1

66

Q96DZ1
CQPYKKKHLVAKTYR

CXorf66

266

Q5JRM2
THRYKKKYVTTLLYK

PRKAB2

256

O43741
QKERTCLHYAVKKKF

ANKRD22

71

Q5VYY1
VYRVKKKYHIVSKAI

MSANTD5

56

A0A3B3IT52
EGCVHYKVVKYERIK

MAP4K4

1021

O95819
LQKTVHTYCGKIYKI

GXYLT1

406

Q4G148
IRKKSEKVLCKYFHS

NDNF

506

Q8TB73
YCRKAYKKIHITKVE

POLE

726

Q07864
RKAYKQVFKCHIRKD

GALR1

311

P47211
KKLLKYMKHTVVVYC

DCAKD

121

Q8WVC6
YKAKIEKKAIYERCS

LINC00032

66

P0C843
IAAKYKHSVVKKCCY

C5

686

P01031
CIIVRTTNKKYYKKF

DPCD

126

Q9BVM2
YHKVDFECILDKRKK

FASTKD1

726

Q53R41
HKCAYIEFKEVFKKV

DNAH14

2041

Q0VDD8
IYYSCLDKKKVEKIR

HHIPL2

291

Q6UWX4
EAALYKHKCKYCSKV

SALL4

376

Q9UJQ4
HLVLYHLSVCCKKKY

PHF1

256

O43189
EIYHCRRQIKYSKDK

MRPL22

66

Q9NWU5
YVKVNLYHAKKRISK

SYT4

326

Q9H2B2
KLYLKEYHYKSKVRV

SOCS4

416

Q8WXH5
LKGDVMVKCYHKKYR

TNS3

236

Q68CZ2
VCEVALDYKKKKHVF

SPTBN1

2261

Q01082
YAYEVIKHKLCRRGK

ASIC1

456

P78348
EAKEYVIKACSRKLY

SUPT6H

736

Q7KZ85
LGYKKYEHVLCTLKV

MKS1

216

Q9NXB0
TVKIEHVSYTEKRKY

STON1

346

Q9Y6Q2
HKKRIEKLEEYTKTC

SMC1B

431

Q8NDV3
ASYLHMYDIVKVCKK

ZBTB18

101

Q99592
YKKIHTGDKLYKCKE

ZNF721

731

Q8TF20
SRKRVKYYVSKIVIH

PRSS48

91

Q7RTY5
TKHKRIYTCEKLYKC

ZNF675

216

Q8TD23
TTHKKNYTRYKLYKC

ZNF43

246

P17038
HKIIRTGEKFYKCKE

ZNF43

276

P17038
VCRKTFKRKDYLKQH

GTF3A

221

Q92664
RYHIDTCKDEIKRYK

WDR27

626

A2RRH5
VVLYKIYDLHKKRSC

PTPRC

596

P08575
KSIYHREKSYKCKEC

ZNF254

201

O75437
VILHKKRYIYRKIKG

TMEM236

71

Q5W0B7
YERVKEYCLKVLKKE

TTC9

146

Q92623
ETRYTGKKHFKCKKY

ZNF722

176

A0A1W2PQL4
KLNYKDCEKAVKKYH

LCP2

26

Q13094