Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

FKBP9 DTNB PLCH2

2.98e-032612131.10.238.10
DomainEF-hand-dom_pair

FKBP9 DTNB PLCH2

3.89e-03287213IPR011992
Pubmed

ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons.

GDF1 CHRNA2

4.99e-051623231676717
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

GDF1 PLCH2 RNASEK NUP88 NGEF

7.95e-0569723528298427
CytobandEnsembl 112 genes in cytogenetic band chr3p22

VIPR1 CYP8B1 KLHL40

1.06e-04184233chr3p22
Cytoband3p22.1

CYP8B1 KLHL40

1.85e-04402323p22.1
GeneFamilyEF-hand domain containing

FKBP9 PLCH2

1.38e-02219152863
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1|Striatum / BrainAtlas - Mouse McCarroll V32

VIPR1 KCNH3 NGEF

5.65e-051462337b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)|bone_marrow / Manually curated celltypes from each tissue

TYMS TERT KLHL40

7.01e-05157233d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

VIPR1 KLHL40 KCNH3

7.28e-0515923318e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

VIPR1 KCNH3 NGEF

7.42e-05160233f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SSPOP CYP8B1 MAN2B1

7.56e-0516123376c993a4533362db2250c88b3ee3ede55362d54e
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

VIPR1 KCNH3 NGEF

7.56e-05161233ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SIK1 KLHL40 TCERG1L

9.03e-05171233f9ae7964a3740f559431125c17c660549798cccc
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SIK1 KLHL40 TCERG1L

9.51e-05174233a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SSPOP CYP8B1 MAN2B1

9.67e-051752334655d3daa95e8ffa7d5ee4180de06b2fec361bfb
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

VIPR1 KCNH3 NGEF

1.12e-0418423325ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

VIPR1 KCNH3 NGEF

1.12e-041842336e17c8151d6dc543de16d804db956c63c3fda414
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VIPR1 KCNH3 NGEF

1.16e-0418623384ba666237c18189d7e7556bd92dd953af733c00
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SIK1 RNASEK MAN2B1

1.20e-04188233fe8c3283f1da7f3ae8dabaa338efebf3947d8658
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VIPR1 KCNH3 NGEF

1.21e-04189233a75226616340045b581d08429d2e123e041dee55
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VIPR1 KCNH3 NGEF

1.23e-0419023349e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell5'|World / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VIPR1 RNASEK MAN2B1

1.25e-041912330e752756e9d1b444930522efc0fdca072d42535f
ToppCellMS-Treg-exh_CD4|MS / Condition, Cell_class and T cell subcluster

ABCB10 PANO1 MAN2B1

1.27e-04192233c6722bf142c84ccedd99c1a3344085aecb4cbab4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP8B1 RNASEK MAN2B1

1.27e-041922334037b4c4fbb40541b8c424c36d3871a57891b8dd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VIPR1 KCNH3 NGEF

1.27e-041922335c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SIK1 RNASEK MAN2B1

1.29e-0419323379a95ac4f46abee00e03700c10cdb00c4507ea76
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SIK1 RNASEK MAN2B1

1.29e-04193233ed44c3192e80134d58b72f1659cd66baf16cfd86
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SIK1 RNASEK MAN2B1

1.33e-041952330766be26be8a992ad8cfffa6102fb6d1ab41e914
ToppCellSkin-Mesangial|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

TERT SSPOP KLHL40

1.41e-04199233bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

VIPR1 KCNH3 NGEF

1.44e-042002334409065bc7aa995354c71e0f9d6f3726cf393d6b
Drugostreasterol

TERT CYP8B1

1.70e-057212CID000092113
Drugtriazinate

TYMS TERT

5.32e-0512212CID000038777
DrugqBBr

TYMS DTNB

1.09e-0417212CID000126515
Drugtetrazolium violet

TYMS TERT

1.37e-0419212CID000074395
DrugAC1L1HWS

TYMS TERT

1.68e-0421212CID000004326
Drugdiphenyl sulfoxide

TYMS TERT

1.85e-0422212CID000013679
Drugimidazolidine

TYMS CHRNA2

2.60e-0426212CID000449488
DrugaraTTP

TYMS TERT

2.80e-0427212CID000072188
DrugAC1LAL87

TYMS DTNB

2.80e-0427212CID000470529
DrugAC1L1C2U

TYMS TERT

2.80e-0427212CID000001716
Drug2d41

VIPR1 SIK1

2.80e-0427212CID009543496
Drugbromoacetylcholine bromide

DTNB CHRNA2

3.24e-0429212CID000204966
Drugdithio

TYMS DTNB

3.47e-0430212CID000019395
Drughypusine

TYMS MAN2B1

4.47e-0434212CID000065396
DrugMIANS

TERT DTNB

5.29e-0437212CID000119532
DrugArg-Asp

TYMS VIPR1

5.29e-0437212CID006426948
DrugNSC693702

TYMS TERT

6.50e-0441212CID000003451
Drugcadmium

TYMS TERT DTNB MAN2B1

6.51e-04443214CID000002514
DrugAC1L2J0W

TYMS TERT

6.82e-0442212CID000072957
DrugAzathymine, 6 [932-53-6]; Up 200; 31.4uM; MCF7; HT_HG-U133A

VIPR1 DTNB CHRNA2

7.23e-041942132827_UP
DrugDilazep dihydrochloride [20153-98-4]; Up 200; 6uM; PC3; HT_HG-U133A

VIPR1 DTNB CHRNA2

7.68e-041982133665_UP
Drugrotenone; Up 200; 1uM; PC3; HT_HG-U133A

VIPR1 DTNB CHRNA2

7.79e-041992135920_UP
Drugbrusatol

TYMS TERT

8.18e-0446212CID000073432
Diseaselung carcinoma

TERT CYP8B1 CHRNA2 TCERG1L

2.77e-04482204EFO_0001071
Diseaseacute lymphoblastic leukemia (is_implicated_in)

TYMS TERT

6.34e-0455202DOID:9952 (is_implicated_in)
DiseaseLung Neoplasms

TYMS TERT CHRNA2

7.29e-04265203C0024121
DiseaseMalignant neoplasm of lung

TYMS TERT CHRNA2

7.37e-04266203C0242379
DiseaseColorectal Neoplasms

ABCB10 TYMS TCERG1L

8.29e-04277203C0009404
Diseaseacute myeloid leukemia (is_implicated_in)

TYMS TERT

1.47e-0384202DOID:9119 (is_implicated_in)
DiseasePancreatic Neoplasm

TYMS TERT

2.08e-03100202C0030297
DiseaseMalignant neoplasm of pancreas

TYMS TERT

2.16e-03102202C0346647
DiseaseGlioblastoma Multiforme

TERT SIK1

2.55e-03111202C1621958
Diseasecutaneous melanoma

TERT DTNB

3.02e-03121202EFO_0000389

Protein segments in the cluster

PeptideGeneStartEntry
HPRGMVPERLPPWLQ

ALKBH6

66

Q3KRA9
PPRLLWGCLMPRAQP

C8orf86

86

Q6ZUL3
LRPPWAPRLERCMVP

DNAH10OS

86

P0CZ25
LGCVPRWLLMNRPPP

CHRNA2

371

Q15822
RWLLMNRPPPPVELC

CHRNA2

376

Q15822
MRGPPAWPLRLLEPP

ABCB10

1

Q9NRK6
PRALEGLRLPPMPWN

KCNH3

801

Q9ULD8
GAPRLRPVPPVMWRL

GDF1

51

P27539
EWLGMPPLPSPRCLF

KLHL40

391

Q2TBA0
WPPRLRPRTCPQMSG

PANO1

81

I0J062
MAFRGWRPPPPPLLL

FKBP9

1

O95302
DPPPQCLVWLPLMHR

DTNB

216

O60941
PWTMSRALRPPLPPL

MAN2B1

21

O00754
LPGMLRQRRPWEPPL

CYP8B1

21

Q9UNU6
KPLPCRQPAPIRGFW

NUP88

456

Q99567
PPWRNQTLCPVMCPG

SSPOP

816

A2VEC9
PLTLNIPWSRMPPCR

NGEF

101

Q8N5V2
RWMRAEPCLPGPACP

SIK1B

276

A0A0B4J2F2
RWMRAEPCLPGPACP

SIK1

276

P57059
RRQPLLWPMDAEPPP

TCERG1L

21

Q5VWI1
MRPPSPLPARWLCVL

VIPR1

1

P32241
PRMAGLPFRPPWGCL

PLCH2

1226

O75038
AWNPRDLPLMALPPC

TYMS

181

P04818
MGWLRPGPRPLCPPA

RNASEK

1

Q6P5S7
WMPGTPRRLPRLPQR

TERT

371

O14746
LLAMWGPQAPPCLCR

ZDHHC1

376

Q8WTX9