Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

MED14 MED12 MED13

7.42e-0618433GO:0042809
GeneOntologyMolecularFunctiontranscription coactivator activity

MED14 MED12L SMARCA2 MED12 MED13 SS18L1

4.42e-05303436GO:0003713
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOR1 MED12 MED13

5.31e-0534433GO:0046966
GeneOntologyMolecularFunctiontranscription coregulator activity

MED14 MED12L SMARCA2 NCOR1 MED12 MED13 SS18L1

1.80e-04562437GO:0003712
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

MED14 MED12 MED13

3.07e-0461433GO:0030374
GeneOntologyMolecularFunctionnuclear receptor binding

MED14 NCOR1 MED12 MED13

6.91e-04187434GO:0016922
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ALX3 EBF2 NCOR1 POU2F2 LHX5 PAX1 NEUROD1 EGR1 LITAF MED12

8.68e-0414594310GO:0000977
GeneOntologyMolecularFunctiontranscription factor binding

MED14 MED12L NCOR1 NEUROD1 BSN MED12 MED13

1.04e-03753437GO:0008134
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

EBF2 POU2F2 PAX1 NEUROD1 EGR1 LITAF

1.20e-03560436GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

EBF2 POU2F2 PAX1 NEUROD1 EGR1 LITAF

1.26e-03566436GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

MED14 NCOR1 NEUROD1 MED12 MED13

1.94e-03417435GO:0061629
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ALX3 EBF2 POU2F2 LHX5 PAX1 NEUROD1 EGR1 MYRF LITAF

2.71e-031412439GO:0000981
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED14 MED12L SMARCA2 NCOR1 MED12 MED13 WNK3 SS18L1

2.98e-031160438GO:0030674
GeneOntologyMolecularFunctionepidermal growth factor receptor binding

ERBB4 ATXN2

3.52e-0341432GO:0005154
GeneOntologyMolecularFunctionchromatin binding

EBF2 SMARCA2 NCOR1 NEUROD1 EGR1 MED12

4.78e-03739436GO:0003682
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

EBF2 MED14 MED12L SMARCA2 POU2F2 PAX1 NEUROD1 EGR1 LITAF MED12 MED13 SS18L1

1.81e-0513904312GO:0045944
GeneOntologyCellularComponentmediator complex

MED14 MED12L MED12 MED13

1.07e-0637444GO:0016592
GeneOntologyCellularComponentinhibitory synapse

ERBB4 IGSF9B BSN

3.75e-0531443GO:0060077
GeneOntologyCellularComponentchromatin

ALX3 EBF2 SMARCA2 NCOR1 POU2F2 RIF1 LHX5 PAX1 NEUROD1 EGR1 ZC3H6 SS18L1

3.81e-0514804412GO:0000785
GeneOntologyCellularComponentCKM complex

MED12 MED13

4.31e-055442GO:1990508
GeneOntologyCellularComponentpostsynaptic density

ERBB4 NEO1 IGSF9B PSD BSN CSMD2

3.44e-04451446GO:0014069
GeneOntologyCellularComponentGABA-ergic synapse

ERBB4 IGSF9B BSN SLC6A17

3.88e-04164444GO:0098982
GeneOntologyCellularComponentasymmetric synapse

ERBB4 NEO1 IGSF9B PSD BSN CSMD2

4.63e-04477446GO:0032279
GeneOntologyCellularComponentnBAF complex

SMARCA2 SS18L1

5.10e-0416442GO:0071565
GeneOntologyCellularComponentpostsynaptic specialization

ERBB4 NEO1 IGSF9B PSD BSN CSMD2

6.12e-04503446GO:0099572
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

MED12 MED13

6.48e-0418442GO:0019908
GeneOntologyCellularComponentneuron to neuron synapse

ERBB4 NEO1 IGSF9B PSD BSN CSMD2

7.50e-04523446GO:0098984
GeneOntologyCellularComponentnuclear protein-containing complex

MED14 MED12L SMARCA2 TRA2A NCOR1 NEUROD1 MED12 MED13 SS18L1

1.98e-031377449GO:0140513
GeneOntologyCellularComponentspindle midzone

RIF1 TTC28

3.21e-0340442GO:0051233
DomainMediator_Med12_catenin-bd

MED12L MED12

5.18e-062432IPR021989
DomainMed12-PQL

MED12L MED12

5.18e-062432PF12144
DomainMed12-LCEWAV

MED12L MED12

5.18e-062432PF12145
DomainMediator_Med12

MED12L MED12

5.18e-062432IPR019035
DomainMed12

MED12L MED12

5.18e-062432SM01281
DomainMed12

MED12L MED12

5.18e-062432PF09497
DomainMediator_Med12_LCEWAV

MED12L MED12

5.18e-062432IPR021990
DomainIg_2

HSPG2 NEO1 IGSF9B MILR1

2.36e-0573434PF13895
DomainSEA

MUC16 HSPG2

4.63e-0414432SM00200
Domainfn3

FNDC1 NEO1 IGSF9B CSF2RB

5.17e-04162434PF00041
Domain-

EBF2 HSPG2 FNDC1 NEO1 IGSF9B CSF2RB MILR1

7.28e-046634372.60.40.10
DomainFN3

FNDC1 NEO1 IGSF9B CSF2RB

8.50e-04185434SM00060
DomainHomeodomain-like

ALX3 NCOR1 POU2F2 LHX5 PAX1

9.52e-04332435IPR009057
DomainIg-like_fold

EBF2 HSPG2 FNDC1 NEO1 IGSF9B CSF2RB MILR1

1.05e-03706437IPR013783
DomainFN3

FNDC1 NEO1 IGSF9B CSF2RB

1.11e-03199434PS50853
DomainSEA

MUC16 HSPG2

1.16e-0322432PF01390
DomainSEA

MUC16 HSPG2

1.27e-0323432PS50024
DomainSEA_dom

MUC16 HSPG2

1.27e-0323432IPR000082
DomainFN3_dom

FNDC1 NEO1 IGSF9B CSF2RB

1.34e-03209434IPR003961
Domain-

ALX3 NCOR1 POU2F2 LHX5

4.00e-032834341.10.10.60
DomainHomeobox_CS

ALX3 POU2F2 LHX5

8.95e-03186433IPR017970
PathwayREACTOME_ADIPOGENESIS

EBF2 MED14 NCOR1 MED12 MED13

7.11e-06110355M48259
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

MED14 NCOR1 MED12 MED13

5.34e-0584354M1008
PathwayREACTOME_RSV_HOST_INTERACTIONS

MED14 HSPG2 MED12 MED13

9.75e-0598354M48247
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

MED14 NCOR1 MED12 MED13

2.00e-04118354M27316
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

MED14 HSPG2 MED12 MED13

2.13e-04120354M48233
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOR1 ERBB4 IGSF9B BSN EGR1 ATXN2 LITAF SETBP1

6.14e-0843044835044719
Pubmed

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

MED14 MED12 MED13

1.58e-0794438710870
Pubmed

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.

MED14 MED12 MED13

2.25e-071044312218053
Pubmed

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

MED14 MED12 MED13

2.25e-071044323746844
Pubmed

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

MED14 MED12 MED13

4.12e-071244323563140
Pubmed

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

MED14 MED12 MED13

5.36e-071344314657022
Pubmed

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

MED14 MED12 MED13

5.36e-071344320098423
Pubmed

Structure, function, and activator-induced conformations of the CRSP coactivator.

MED14 MED12 MED13

6.81e-071444311834832
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED14 MED12 MED13

8.50e-071544318418385
Pubmed

The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.

MED14 MED12 MED13

1.05e-061644310882111
Pubmed

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

MED14 MED12 MED13

1.27e-061744310235266
Pubmed

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.

MED14 MED12 MED13

1.52e-061844310198638
Pubmed

Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.

MED12L MYRF MED12

1.52e-061844323575864
Pubmed

The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines.

SMARCA2 EGR1

1.56e-06244225673149
Pubmed

Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14.

MED14 CSF2RB

1.56e-06244223572530
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED14 MED12 MED13

1.80e-061944316799563
Pubmed

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.

MED14 MED12 MED13

2.12e-062044315340084
Pubmed

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

MED14 MED12 MED13

2.86e-062244311867769
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED14 MED12 MED13

3.29e-062344310235267
Pubmed

MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers.

SMARCA2 EGR1

4.69e-06344221189327
Pubmed

The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment monitoring.

NEUROD1 EGR1

4.69e-06344228072411
Pubmed

Mediator kinase module and human tumorigenesis.

MED12 MED13

4.69e-06344226182352
Pubmed

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

MED14 MED12 MED13

4.81e-062644334506481
Pubmed

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.

MED14 MED12 MED13

6.75e-062944314638676
Pubmed

Integrating genetic and network analysis to characterize genes related to mouse weight.

RIF1 KIDINS220 PYROXD2

6.75e-062944316934000
Pubmed

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

MED14 MED12 MED13

8.28e-063144323322298
Pubmed

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.

NCOR1 ERBB4

9.37e-06444217018285
Pubmed

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

MED12 MED13

9.37e-06444219047373
Pubmed

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

MED14 TRA2A MED12 MED13

1.05e-0510744420508642
Pubmed

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

MED14 MED12 MED13

1.10e-053444315989967
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SMARCA2 MUC16 NCOR1 BSN CSMD2 TTC28 SS18L1

1.44e-0563844731182584
Pubmed

A census of human transcription factors: function, expression and evolution.

ALX3 POU2F2 LHX5 PAX1 NEUROD1 EGR1 MYRF SETBP1

1.61e-0590844819274049
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MED14 MED12 MED13

1.67e-053944338690566
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

MED14 RIF1 EGR1 MED12 MED13 SS18L1

2.19e-0545344629656893
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MED14 SMARCA2 NCOR1 MED12 MED13

2.22e-0526844533640491
Pubmed

Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).

HSPG2 PAX1

2.34e-0564429486530
Pubmed

Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.

MED12L MED12

2.34e-05644211524702
Pubmed

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

MED14 MED12 MED13

2.95e-054744315175163
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED14 SMARCA2 TRA2A NCOR1 RIF1 MED12 MED13 CAPG

3.54e-05101444832416067
Pubmed

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

MED12 MED13

4.36e-05844230695077
Pubmed

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

MED14 MED12

5.60e-05944214636573
Pubmed

Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes.

ALX3 PAX1

5.60e-05944215728667
Pubmed

Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.

ERBB4 NEUROD1

5.60e-05944210655590
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

MED14 MED12 MED13

5.84e-055944328813667
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED14 RIF1 MED12 MED13

5.99e-0516744420362541
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

ALX3 POU2F2 LHX5 PAX1 NEUROD1 EGR1

6.07e-0554444628473536
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

SMARCA2 NCOR1 POU2F2 RIF1 NEUROD1 EGR1 ZC3H6

6.45e-0580844720412781
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

MED14 TRA2A NCOR1 RIF1 MED12

6.98e-0534144532971831
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

SMARCA2 NEUROD1 SS18L1

7.81e-056544326655900
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

MED14 SMARCA2 MED12

8.18e-056644323275444
Pubmed

Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.

HSPG2 NEO1

8.54e-051144215186747
Pubmed

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.

MED14 MED12

8.54e-051144212037571
Pubmed

Streamlined analysis schema for high-throughput identification of endogenous protein complexes.

MED14 MED12 MED13

1.02e-047144320133760
Pubmed

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.

RIF1 BSN

1.02e-041244228700933
Pubmed

LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.

EBF2 LHX5

1.02e-041244220685998
Pubmed

A shared transcriptional code orchestrates temporal patterning of the central nervous system.

POU2F2 LHX5

1.02e-041244234767545
Pubmed

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

MED14 MED12 MED13

1.10e-047344321729782
Pubmed

Characterization of Olig2 expression during cerebellar development.

LHX5 NEUROD1

1.21e-041344224594479
Pubmed

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

MED12 MED13

1.21e-041344227570068
Pubmed

Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PAX1 SETBP1

1.21e-041344222693459
Pubmed

FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification.

MED14 MED12 MED13

1.35e-047844325720964
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

SMARCA2 TRA2A NCOR1

1.35e-047844328611094
Pubmed

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.

SMARCA2 SS18L1

1.41e-041444236289231
Pubmed

A Method to Identify p62's UBA Domain Interacting Proteins.

NCOR1 ULK2

1.41e-041444214702098
Pubmed

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

MED14 MED13

1.41e-041444210024883
Pubmed

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development.

HSPG2 PAX1

1.41e-041444228011632
Pubmed

Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.

SMARCA2 SS18L1

1.63e-041544223785148
Pubmed

Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.

MED12L SMARCA2

1.63e-041544219762545
Pubmed

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.

LHX5 NEO1

1.86e-041644227223328
Pubmed

Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.

EBF2 NEUROD1

1.86e-041644217521568
Pubmed

Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.

SMARCA2 MYRF

1.86e-041644225568100
Pubmed

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

MED14 MED12

2.10e-041744216109376
Pubmed

Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development.

SMARCA2 LHX5

2.10e-041744219135992
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

SMARCA2 NCOR1

2.10e-041744219183483
Pubmed

Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.

HSPG2 PAX1

2.36e-041844212571105
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

MED14 SMARCA2 MED12

2.72e-049944334161765
Pubmed

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

MED12 MED13

2.93e-042044217967894
Pubmed

The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons.

ALX3 NEUROD1

2.93e-042044215173589
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

NCOR1 IGSF9B TTC28

3.15e-0410444310470851
Pubmed

A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord.

LHX5 NEUROD1

3.24e-042144218721803
Pubmed

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.

ALX3 PAX1

3.24e-042144212142027
Pubmed

Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.

NEO1 NEUROD1

3.56e-042244222726835
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

ATXN2 MED12

3.89e-04234429225980
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

MED12L HSPG2 NCOR1 NEO1 MED13

4.01e-0449744523414517
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

MUC16 NCOR1 RIF1 NEO1 KIDINS220 TTC28

4.18e-0477744635844135
Pubmed

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.

SMARCA2 RIF1

4.24e-042444218454139
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED14 SMARCA2 NCOR1 EGR1 ATXN2 MED12 CAPG

4.35e-04110344734189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MED14 HSPG2 NCOR1 MYRF ULK2 MED12 MED13

4.40e-04110544735748872
Pubmed

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

MED12 MED13

4.61e-042544219240132
Pubmed

Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.

EBF2 LHX5

5.38e-042744233760820
Pubmed

Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.

LHX5 NEO1 NEUROD1

5.52e-0412644316284245
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

MED14 MED12

5.79e-042844220720539
Pubmed

Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.

LHX5 NEUROD1

5.79e-042844235942939
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

TTC28 MED13 CEMIP

6.04e-0413044312421765
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

SMARCA2 NCOR1 CAPG

6.18e-0413144334551306
Pubmed

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

SMARCA2 SS18L1

6.21e-042944219279220
Pubmed

Multimodal Hox5 activity generates motor neuron diversity.

EBF2 NEUROD1

6.21e-042944239289460
Pubmed

Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.

ALX3 NEO1

6.65e-043044238404688
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ALX3 LHX5 PAX1 NEUROD1 EGR1 SS18L1

7.88e-0487744620211142
Pubmed

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

ALX3 ERBB4

8.55e-043444212086465
InteractionCDK8 interactions

MED14 MED12L SMARCA2 TRA2A RIF1 EGR1 MED12 MED13

2.41e-08222448int:CDK8
InteractionNR3C1 interactions

MED14 SMARCA2 MUC16 TRA2A NCOR1 POU2F2 BSN CSMD2 TTC28 EGR1 C1orf94 SS18L1

7.63e-079744412int:NR3C1
InteractionMED30 interactions

MED14 MED12L MED12 MED13 SS18L1

1.07e-0684445int:MED30
InteractionMED6 interactions

MED14 MED12L EGR1 MED12 MED13

2.66e-06101445int:MED6
InteractionMED12L interactions

MED14 MED12L MED12 MED13

3.29e-0647444int:MED12L
InteractionNR1I3 interactions

MED14 NCOR1 MED12 MED13

3.58e-0648444int:NR1I3
InteractionMED13L interactions

MED14 MED12L MED12 MED13

1.73e-0571444int:MED13L
InteractionMED11 interactions

MED14 MED12L MED12 MED13

1.73e-0571444int:MED11
InteractionMED18 interactions

MED14 MED12L MED12 MED13

2.91e-0581444int:MED18
InteractionMED22 interactions

MED14 MED12L MED12 MED13

3.52e-0585444int:MED22
InteractionMED13 interactions

MED14 MED12L MED12 MED13

3.68e-0586444int:MED13
InteractionCDK19 interactions

MED14 MED12L MED12 MED13

4.03e-0588444int:CDK19
InteractionMED7 interactions

MED14 MED12L MED12 MED13

4.80e-0592444int:MED7
InteractionMED10 interactions

MED14 MED12L MED12 MED13

7.19e-05102444int:MED10
InteractionMED29 interactions

MED14 MED12L MED12 MED13

7.19e-05102444int:MED29
InteractionMED27 interactions

MED14 MED12L MED12 MED13

7.19e-05102444int:MED27
InteractionMED19 interactions

MED14 MED12L MED12 MED13

8.35e-05106444int:MED19
InteractionMED26 interactions

MED14 MED12L MED12 MED13

8.66e-05107444int:MED26
InteractionMED9 interactions

MED14 MED12L MED12 MED13

8.98e-05108444int:MED9
InteractionMED28 interactions

MED14 MED12L MED12 MED13

1.18e-04116444int:MED28
InteractionOAZ3 interactions

ATXN2 C1orf94 CAPG

1.29e-0445443int:OAZ3
InteractionMED16 interactions

MED14 MED12L MED12 MED13

1.35e-04120444int:MED16
InteractionMED8 interactions

MED14 MED12L MED12 MED13

1.39e-04121444int:MED8
InteractionTP53BP1 interactions

ALX3 MED14 RIF1 EGR1 MED12 MED13 SS18L1

1.43e-04533447int:TP53BP1
InteractionMED31 interactions

MED14 MED12L MED12 MED13

1.58e-04125444int:MED31
InteractionVDR interactions

MED14 NCOR1 MED12 MED13

1.68e-04127444int:VDR
InteractionPITX1 interactions

SMARCA2 NEUROD1 EGR1 C1orf94

1.68e-04127444int:PITX1
InteractionMED24 interactions

MED14 MED12L MED12 MED13

1.73e-04128444int:MED24
InteractionMED15 interactions

MED14 MED12L MED12 MED13

1.89e-04131444int:MED15
InteractionPTPRT interactions

PHKA1 ERBB4

2.53e-0411442int:PTPRT
InteractionMED23 interactions

MED14 MED12L TTC28 MED12 MED13

2.75e-04266445int:MED23
InteractionSREBF1 interactions

MED14 SMARCA2 MED12 MED13

3.18e-04150444int:SREBF1
InteractionMED21 interactions

MED14 MED12L MED12 MED13

3.96e-04159444int:MED21
InteractionACAD11 interactions

MED14 MED12L MED12 MED13

4.15e-04161444int:ACAD11
InteractionRNF41 interactions

NCOR1 RIF1 ERBB4 CSF2RB

4.45e-04164444int:RNF41
InteractionMED14 interactions

MED14 MED12L MED12 MED13

5.21e-04171444int:MED14
InteractionACTN2 interactions

MED14 SMARCA2 NCOR1 ATXN2

5.21e-04171444int:ACTN2
InteractionMED12 interactions

MED14 MED12L MED12 MED13

5.81e-04176444int:MED12
InteractionMED20 interactions

MED14 MED12L MED12 MED13

6.45e-04181444int:MED20
InteractionCCNC interactions

MED14 MED12L MED12 MED13

7.44e-04188444int:CCNC
Cytoband1p34.3

CSMD2 C1orf94

1.64e-03624421p34.3
Cytoband1p13.3

ALX3 SLC6A17

2.02e-03694421p13.3
GeneFamilyCyclins|Mediator complex

MED14 MED12L MED12 MED13

2.79e-07333141061
GeneFamilyFibronectin type III domain containing

FNDC1 NEO1 IGSF9B CSF2RB

1.54e-04160314555
GeneFamilyImmunoglobulin like domain containing

HSPG2 NEO1 IGSF9B MILR1

3.16e-04193314594
GeneFamilyAtaxins|Trinucleotide repeat containing

ATXN2 MED12

8.33e-0425312775
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

HSPG2 NEO1 IGSF9B

2.59e-03161313593
ToppCell3'_v3-lymph-node_spleen-Mast|lymph-node_spleen / Manually curated celltypes from each tissue

HSPG2 CSF2RB EGR1 WNK3 CAPG

1.03e-0618444583675c7a083c52fb74dc8b9d35df0ef69715f707
ToppCell3'_v3-lymph-node_spleen-Mast-Mast_cells|lymph-node_spleen / Manually curated celltypes from each tissue

HSPG2 CSF2RB EGR1 WNK3 CAPG

1.03e-06184445ed266bd2d12f86e8786473e64fbcd58319cd4c2a
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 CSF2RB MILR1 CAPG

1.97e-051624449d6931619f5eb847c79d00ff5ae031fef30fd55c
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PSD TTC28 MED12 CAPG

2.27e-05168444ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

MED12L CSF2RB MILR1 SETBP1

2.27e-051684445a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

EBF2 PSD MYRF CEMIP

2.90e-0517944498c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCellLPS_only-Myeloid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POU2F2 CSF2RB LITAF CAPG

3.10e-05182444666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCellLPS-antiTNF-Myeloid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POU2F2 CSF2RB LITAF CAPG

3.37e-05186444839c6da5244f469461b2e5563e36162b2911cd01
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EBF2 HSPG2 FNDC1 EGR1

3.59e-05189444bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EBF2 HSPG2 FNDC1 EGR1

3.67e-05190444f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EBF2 HSPG2 FNDC1 EGR1

3.67e-05190444c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCelldroplet-Mammary_Gland-nan-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 FNDC1 EGR1 CAPG

3.74e-051914448022059e434fd411dc539819f969bd4f94861281
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRA2A POU2F2 CSF2RB SETBP1

3.90e-0519344408696a99309f5b088692ddac8cca35413b5e810d
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOR1 NEUROD1 TTC28 EGR1

3.98e-051944443a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOR1 NEUROD1 TTC28 EGR1

3.98e-051944440b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TTC28 EGR1 WNK3 SETBP1

4.06e-05195444ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOR1 RIF1 NEUROD1 TTC28

4.06e-051954443e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOR1 RIF1 NEUROD1 TTC28

4.06e-051954447796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-Trachea|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EBF2 HSPG2 EGR1 CAPG

4.14e-051964448209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCellfacs-Trachea|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EBF2 HSPG2 EGR1 CAPG

4.14e-0519644434020d6553309daa269dff05de0a8567211ea4d2
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 FNDC1 MYRF WNK3

4.22e-0519744488a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 FNDC1 MYRF WNK3

4.22e-051974442773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

CSMD2 TTC28 SETBP1 CEMIP

4.22e-05197444f1c8936986123a3151140c374fcd62d6705c530b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EBF2 POU2F2 LHX5 NEUROD1

4.22e-05197444c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EBF2 POU2F2 NEUROD1 KIDINS220

4.22e-051974442d92b0483d57541aee382dda80e42cf66e813d6b
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

CSMD2 TTC28 SETBP1 CEMIP

4.22e-05197444fb847f2277609c31fffcdf49517243ce0684facf
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

POU2F2 CSF2RB LITAF CAPG

4.30e-051984449aee419c59105d8a7ad83bc484b92d30a640666b
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

POU2F2 CSF2RB LITAF CAPG

4.30e-05198444c4a004f211f72f28aacbb512c6e075cbd049be53
ToppCellLPS_IL1RA-Hematopoietic_Myeloid|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

POU2F2 CSF2RB LITAF CAPG

4.39e-051994440e696f13c9bd135fbb31368d6dca29897d6a1a25
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.

SMARCA2 ERBB4 KIDINS220 BSN

4.39e-05199444b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCellLPS_only-Hematopoietic_Myeloid|LPS_only / Treatment groups by lineage, cell group, cell type

POU2F2 CSF2RB LITAF CAPG

4.39e-0519944420523dee39a4c5f6423259920f108127b47525c4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

EBF2 ERBB4 LHX5 WNK3

4.48e-05200444ac0e023dbb383bbc46c5cc525431778be8f7ef46
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Mast_cell-Mast_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CSF2RB EGR1 WNK3 CAPG

4.48e-05200444a338b2b94901e4614ef78e82f580b67891f7c849
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Neuron|1m / Sample Type, Dataset, Time_group, and Cell type.

EBF2 POU2F2 LHX5 NEUROD1

4.48e-05200444be1e153119ca4946b4eaef6037e8465f5c00ca6f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Neuron|5w / Sample Type, Dataset, Time_group, and Cell type.

EBF2 LHX5 NEUROD1 ARHGEF33

4.48e-052004446f3fe94107fa2a2ded4888780b36700cce48adb7
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

EBF2 POU2F2 LHX5 KIDINS220

4.48e-05200444979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Mast_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CSF2RB EGR1 WNK3 CAPG

4.48e-0520044421de2cf284c8d2aa464f3d403f0e292e1f654e0a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ERBB4 NEUROD1 KIDINS220

1.17e-049644356e993d37b7958abe56682422536045550e29b41
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Interneuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

ERBB4 IGSF9B EGR1

2.61e-04126443ec445ec097c9c45cd47b8cfa8c140df5b298695e
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ALX3 EBF2 CEMIP

2.99e-04132443560e836764ed7806fb18282dfebe434d30112a9a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

ALX3 EBF2 HSPG2

3.13e-04134443b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c3-LAMP3|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EBF2 MED12L CEMIP

3.48e-04139443bb2b020dda32ddc60ec9952de5b01acee60b5b59
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ALX3 MED12L SLC6A17

3.48e-04139443c9bf98bed77415a1438f3f9e441a1346e75c26b0
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

IGSF9B PSD BSN

3.94e-041454431e52e3c615b49e7388cd58a04e74cafac9552447
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CSF2RB MILR1

4.18e-04148443bbf4933582b50b3412c805de5ed137107c996236
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CSF2RB MILR1

4.18e-041484436543860e3207a7de92a35bb6004be51287582f7a
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 CSF2RB MILR1

4.18e-0414844379e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

IGSF9B PSD BSN

4.27e-04149443649eb3441fa859591ea85f1ed5fcf08af272a32b
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BSN CSF2RB EGR1

4.52e-041524430fda8980b10ce16179dea92301db74d728f41794
ToppCellPND01-Immune-Immune_Myeloid-DC-cDC2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 CSF2RB MILR1

4.52e-04152443cefc0ab592e99badf145fb95adf9906cb81be81c
ToppCellPND01-Immune-Immune_Myeloid-DC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 CSF2RB MILR1

4.52e-04152443c8faa83dcaddb2ce2bb890f90dd8e676f7dcb1b3
ToppCellPND01-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POU2F2 CSF2RB MILR1

4.52e-04152443c3f00beb8b6fde99263d5ed6bbe3c2415d02f91d
ToppCellfacs-Lung-Endomucin-24m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MILR1 CAPG

4.61e-041534439c3220604b7fa4d91577b6c46960960f49644ca1
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|Myeloid_cells / Location, Cell class and cell subclass

EGR1 SS18L1 PYROXD2

4.61e-041534435424494ea1f09542799045a875cc3eac13de5079
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MILR1 CAPG

4.61e-04153443ba624782693b0daa642e50881dbf5f0663fea82d
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 SLC6A17 CEMIP

4.79e-041554438fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EBF2 NEUROD1 SETBP1

4.88e-041564437e6805ebc7bc2f9c5965321d16922c155719970f
ToppCellMyeloid-A_(Macrophage-Dendritic)|World / shred on cell class and cell subclass (v4)

CSF2RB MILR1 CAPG

4.88e-0415644308d5f7fe098b6f2caeeddcc5ed1e34d6a59e697b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

EBF2 NEUROD1 SETBP1

4.88e-04156443741de05295b2d012ac8576378f37709a97c8fb50
ToppCellE16.5-samps-Myeloid|E16.5-samps / Age Group, Lineage, Cell class and subclass

POU2F2 CSF2RB MILR1

4.88e-04156443c7c73cef5700b0ae75280e62c94728434c712537
ToppCelldroplet-Kidney-nan-18m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSD CSF2RB MILR1

4.97e-04157443eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MED12L CSF2RB MILR1

5.06e-04158443f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MILR1 CAPG

5.06e-04158443bd37d567754b660bfff7aef81cb307a384ec20a0
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MILR1 CAPG

5.06e-04158443ad1040bce6ad655c2502d9abb02507ecff177f83
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

CSF2RB MILR1 SETBP1

5.06e-041584432af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MILR1 CAPG

5.06e-04158443ac7aef01eda1dca80d6c5b508649fcad55803a67
ToppCellsevere_COVID-19-pDC|World / disease group, cell group and cell class (v2)

MED12L HSPG2 TTC28

5.16e-04159443e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCellmetastatic_Brain-Myeloid_cells-CD1c+_DCs|metastatic_Brain / Location, Cell class and cell subclass

POU2F2 CSF2RB MILR1

5.16e-0415944335a63ca521635389a1edc7c81157793b8ad24d38
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGSF9B NEUROD1 EGR1

5.16e-04159443a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CSF2RB MILR1 CAPG

5.16e-04159443dd9059f98eec43adbcc0cd42bb155670f7a3a479
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ERBB4 EGR1 SLC6A17

5.16e-04159443fb9a45c1d596226128ce4f1adaebb066766e590a
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

MED12L HSPG2 TTC28

5.16e-04159443ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CSF2RB MILR1 CAPG

5.25e-041604436393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGSF9B NEUROD1 EGR1

5.25e-04160443d8241404d775f9a709abdf17988f36293fcf4c58
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L ERBB4 SLC6A17

5.25e-041604438bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCellE12.5-Hematopoietic-Immune-immune_cell_unspecified|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

POU2F2 CSF2RB MILR1

5.25e-041604435a4a5a50dfdf6af9406e4f685712f7fe390a02f3
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CSF2RB MILR1 CAPG

5.25e-041604432065938e944eb99478fd8132c2c03adeaee6d447
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MED12L ERBB4 SLC6A17

5.25e-041604432d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCellE12.5-Hematopoietic-Immune|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

POU2F2 CSF2RB MILR1

5.25e-04160443cd59830a524c14a1f591c5c615b55510e4104e5b
ToppCellMyeloid|World / shred on cell class and cell subclass (v4)

CSF2RB MILR1 CAPG

5.35e-04161443aee407d3739dba2d5216dcdb1579e7e4f483123d
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L POU2F2 CAPG

5.45e-04162443e81dec1db8e5a808d96e58410c91961e5d065c94
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 POU2F2 NEO1

5.45e-041624432259e9536147e9cdee772e3a30ba7d104573262c
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L POU2F2 CAPG

5.45e-04162443d19b469f64c9064cfb82dadb6c8135e28949a02a
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MED12L POU2F2 CAPG

5.45e-0416244310c2aa047f33f48e4abe676236bbdb593079dd1d
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CSF2RB MILR1 CAPG

5.54e-0416344345a0a03d642a9751f522b2f068598ab5de4a87bd
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_C|TCGA-Thymus / Sample_Type by Project: Shred V9

MUC16 FNDC1 IGSF9B

5.54e-041634432dac87d15051151ccf193760ddd8b82534c3f922
ToppCellInfluenza_Severe-NK_CD56bright|Influenza_Severe / Disease group and Cell class

NEO1 PSD PYROXD2

5.54e-041634437748d5709e8cf6673f5a8370108309f76cd830f4
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRA2A POU2F2 SETBP1

5.54e-041634436bed27d2f67a430a847da5eb47878d14b4949c45
ToppCellFrontal_cortex|World / BrainAtlas - Mouse McCarroll V32

PSD EGR1 C1orf94

5.64e-04164443e09291711abf8680e78170328313719092b0142f
ToppCell3'_v3-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

POU2F2 PSD EGR1

5.64e-041644437766900740f67dbbe3c4d90fbfdcc1665cee6515
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ALX3 EBF2 CEMIP

5.74e-04165443570483b43ccb5831feec9337b4664814431d40b1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ALX3 EBF2 CEMIP

5.74e-041654432026a9a07f4d314cc05c167e491312b373468e46
ToppCellremission-HSPC|World / disease stage, cell group and cell class

MED12L HSPG2 CSF2RB

5.85e-04166443d269ee6f7adb55b05dcb5eaea96629ccb0b2d6e3
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|367C / Donor, Lineage, Cell class and subclass (all cells)

CSF2RB EGR1 MED13

5.85e-04166443430d604f5bef9fae20dc81492e6695616f6701a3
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKA1 CSF2RB ULK2

5.85e-0416644313027ae342994db4540e64eb910df1f42b160931
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHKA1 CSF2RB ULK2

5.85e-04166443b21e45bd43f26149b9cd6e45c19241c82d54fb2f
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGSF9B NEUROD1 EGR1

5.95e-04167443f1ce6e64ebede1f3ef36fe982f46919fd1f814dd
ToppCellfacs-Spleen-nan-24m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 LITAF CAPG

5.95e-041674439a8e291c082d7c26bab21df77bd36ce927032a70
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POU2F2 NEUROD1 CAPG

5.95e-04167443691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCellfacs-Lung-3m-Hematologic-myeloid-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CSF2RB MILR1 CAPG

6.05e-04168443af4c35c0d3f030cef8397c35fa498a71112bb16b
DiseaseClumsiness - motor delay

MED12L MED13

2.07e-062432C0520947
DiseaseMotor delay

MED12L MED13

6.22e-063432C1854301
DiseaseDelayed speech and language development

MED12L MED13

2.07e-055432C0454644
Diseasebiological sex

SMARCA2 IGSF9B TTC28 ATXN2 SETBP1

2.08e-05230435PATO_0000047
DiseaseSchizophrenia

SMARCA2 ERBB4 PSD CSF2RB CSMD2 ATXN2 MED12 WNK3

3.57e-05883438C0036341
Diseaseparental longevity

SMARCA2 ERBB4 BSN ATXN2 SETBP1 CEMIP

7.70e-05494436EFO_0007796
Diseaseprostate carcinoma

EBF2 POU2F2 RIF1 BSN TTC28 WNK3 SETBP1

2.79e-04891437EFO_0001663
Diseasecystatin C measurement

EBF2 ERBB4 BSN ATXN2 CEMIP

2.88e-04402435EFO_0004617
Diseasewaist-hip ratio

EBF2 ERBB4 KIDINS220 TTC28 ATXN2 LITAF SETBP1 CEMIP

3.44e-041226438EFO_0004343
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

BSN ATXN2 MYRF LITAF

8.89e-04295434EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Diseaseage at menopause

TRA2A RIF1 TTC28 MED12

9.69e-04302434EFO_0004704
DiseaseSquamous cell carcinoma of lung

ERBB4 WNK3

1.00e-0332432C0149782
Diseasecoronary aneurysm

CSMD2 SETBP1

1.20e-0335432EFO_1000881
Diseasesex interaction measurement, Crohn's disease

BSN LITAF

1.34e-0337432EFO_0000384, EFO_0008343

Protein segments in the cluster

PeptideGeneStartEntry
SEIGHSPPPAYTPMS

ERBB4

1046

Q15303
HPGSPPHSQMSGDSY

CSMD2

2776

Q7Z408
IPSPCMSPYSHPHGS

ALX3

266

O95076
YPSAPSSGPAITHLM

ARHGEF33

501

A8MVX0
GSPTGSPYGIMSSSP

EBF2

501

Q9HAK2
GSTSGGPLMHSPYFS

C1orf94

576

Q6P1W5
HVPTGPSVGMYSPGY

CEMIP

701

Q8WUJ3
PSVGMYSPGYSEHIP

CEMIP

706

Q8WUJ3
HGTHSGPSYTPVPGS

HSPG2

2136

P98160
MSVPGPYQAATGPSS

LITAF

1

Q99732
GDPAPSTSMPVHGSS

MUC16

5161

Q8WXI7
VSPQPHSSYYSGMTG

KIDINS220

1116

Q9ULH0
YHMASSTGDGPVPVP

MED12L

206

Q86YW9
PGTSMTPSSGSFPSA

PHKA1

1026

P46020
SAIYHAGLAPTPPSM

ATXN2

1191

Q99700
GHYAGQTPMPTTQST

BSN

3116

Q9UPA5
SPGSSTYPSPVHSGF

EGR1

476

P18146
SPGKPASYSPHMVTP

POU2F2

366

P09086
ASYSPHMVTPQGGAG

POU2F2

371

P09086
PFPMSGTSGYSGPLS

LHX5

376

Q9H2C1
HTGPAGTMVPPSYSS

MED12

1956

Q93074
PPSKYPSDMSHPGSL

GOLGA6L7

551

A0A1B0GV03
ATYSHPVTMPSTGGD

MILR1

206

Q7Z6M3
SPHGTLDPSSPYTMV

MED14

1086

O60244
YPSPVSPTGAKMGSH

PAX1

256

P15863
PPGSMSAFTSGSPPH

CSF2RB

496

P32927
YTTRAPPGHFSTTPM

FNDC1

1281

Q4ZHG4
MYTAIPQSGSPFPGS

CAPG

1

P40121
VPQSPPASMYGSTGS

PSD

31

A5PKW4
HSQGYMSPHPSPLGA

SMARCA2

116

P51531
NPMTPVHKGASSPYG

RIF1

391

Q5UIP0
HPGGTSTPPMDRITY

NCOR1

1666

O75376
DYKPPMSGSNSPHGS

NEO1

1081

Q92859
YTPQTHTSFGMPPSS

MED13

976

Q9UHV7
PTTSMSISGPGYSHA

SS18L1

141

O75177
HIYSSGSSPGPGPNM

ZC3H6

471

P61129
SLTPPSMGGAYHSPG

ZC3H6

541

P61129
GAMTSPHTPGSGYVL

PYROXD2

251

Q8N2H3
PAMGFTTLATGYPSP

IGSF9B

1271

Q9UPX0
HTPTPGIYMGRPTHS

TRA2A

201

Q13595
PVPVPMYSGSVSGSS

ULK2

281

Q8IYT8
MSPSSGHQSPAGSAP

TTC28

2306

Q96AY4
SPMPTHRSYLGPGST

SLC6A17

686

Q9H1V8
SYDSSMSPGMPSPHL

SETBP1

1326

Q9Y6X0
SFPGPLSSYGMPHVC

WNK3

1726

Q9BYP7
SASYSHGQPAMPGSS

MYRF

56

Q9Y2G1
LPSPPYGTMDSSHVF

NEUROD1

226

Q13562