Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	opsonin binding	CFH MEGF10 CFHR3	3.90e-05	25	53	3	GO:0001846
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST3 NDST4	4.13e-05	4	53	2	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST3 NDST4	4.13e-05	4	53	2	GO:0050119
GeneOntologyMolecularFunction	complement binding	CFH MEGF10 CFHR3	8.29e-05	32	53	3	GO:0001848
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR3	4.49e-04	12	53	2	GO:0001851
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST3 NDST4	7.10e-04	15	53	2	GO:0034483
GeneOntologyMolecularFunction	glycosaminoglycan binding	CFH CEL HABP2 TNFRSF11B CFHR3	7.12e-04	268	53	5	GO:0005539
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	NDST3 CEL DDHD1 PON1	7.98e-04	157	53	4	GO:0052689
GeneOntologyMolecularFunction	plus-end-directed microtubule motor activity	KIF1A KIF1C	9.16e-04	17	53	2	GO:0008574
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	NDST3 NDST4 NGLY1	1.30e-03	81	53	3	GO:0016811
GeneOntologyBiologicalProcess	dense core granule transport	KIF1A EIPR1 KIF1C	6.05e-06	14	54	3	GO:1901950
GeneOntologyBiologicalProcess	dense core granule localization	KIF1A EIPR1 KIF1C	5.31e-05	28	54	3	GO:0032253
GeneOntologyBiologicalProcess	secretory granule localization	KIF1A EIPR1 KIF1C	9.58e-05	34	54	3	GO:0032252
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF1A KIF1C	1.00e-04	6	54	2	GO:1990049
GeneOntologyBiologicalProcess	protein import into peroxisome matrix, receptor recycling	USP9X PEX5	1.40e-04	7	54	2	GO:0016562
GeneOntologyBiologicalProcess	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	USP9X CSNK2A2 SMARCC1	1.81e-04	42	54	3	GO:0032435
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1A KIF1C	1.86e-04	8	54	2	GO:1990048
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST3 NDST4	1.86e-04	8	54	2	GO:0015014
HumanPheno	Calcification of cartilage	DDR2 PEX5 TNFRSF11B	1.72e-05	12	23	3	HP:0100593
Domain	HSNSD	NDST3 NDST4	4.55e-05	4	52	2	PF12062
Domain	Heparan_SO4_deacetylase	NDST3 NDST4	4.55e-05	4	52	2	IPR021930
Domain	Kinesin_assoc	KIF1A KIF1C	1.13e-04	6	52	2	PF16183
Domain	Kinesin_assoc	KIF1A KIF1C	1.13e-04	6	52	2	IPR032405
Domain	EMI_domain	MEGF11 MEGF10	8.90e-04	16	52	2	IPR011489
Domain	EMI	MEGF11 MEGF10	1.01e-03	17	52	2	PS51041
Domain	Galactose-bd-like	PCSK1 DDR2 NGLY1	2.28e-03	94	52	3	IPR008979
Domain	hEGF	MEGF11 MEGF10	2.74e-03	28	52	2	PF12661
Domain	FHA	KIF1A KIF1C	2.74e-03	28	52	2	SM00240
Domain	FHA_DOMAIN	KIF1A KIF1C	3.36e-03	31	52	2	PS50006
Domain	FHA	KIF1A KIF1C	3.36e-03	31	52	2	PF00498
Domain	Kinase-like_dom	TTBK2 CSNK2A2 DDR2 SMARCC1 MAPK6 RIOK2	3.81e-03	542	52	6	IPR011009
Domain	Laminin_EGF	MEGF11 MEGF10	4.27e-03	35	52	2	PF00053
Domain	EGF_Lam	MEGF11 MEGF10	4.27e-03	35	52	2	SM00180
Domain	FHA_dom	KIF1A KIF1C	4.51e-03	36	52	2	IPR000253
Domain	Sulfotransferase_dom	NDST3 NDST4	4.51e-03	36	52	2	IPR000863
Domain	Sulfotransfer_1	NDST3 NDST4	4.51e-03	36	52	2	PF00685
Domain	-	KIF1A KIF1C	4.51e-03	36	52	2	2.60.200.20
Domain	Laminin_EGF	MEGF11 MEGF10	5.01e-03	38	52	2	IPR002049
Domain	Kinesin_motor_CS	KIF1A KIF1C	5.82e-03	41	52	2	IPR019821
Domain	Kinesin-like_fam	KIF1A KIF1C	6.38e-03	43	52	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF1A KIF1C	6.67e-03	44	52	2	PS00411
Domain	-	KIF1A KIF1C	6.67e-03	44	52	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF1A KIF1C	6.67e-03	44	52	2	IPR001752
Domain	Kinesin	KIF1A KIF1C	6.67e-03	44	52	2	PF00225
Domain	KINESIN_MOTOR_2	KIF1A KIF1C	6.67e-03	44	52	2	PS50067
Domain	KISc	KIF1A KIF1C	6.67e-03	44	52	2	SM00129
Domain	Sushi	CFH CFHR3	9.22e-03	52	52	2	PF00084
Domain	SMAD_FHA_domain	KIF1A KIF1C	9.22e-03	52	52	2	IPR008984
Domain	WD40_repeat_dom	KNTC1 CFAP251 EIPR1 BRWD3	9.32e-03	297	52	4	IPR017986
Domain	CCP	CFH CFHR3	9.92e-03	54	52	2	SM00032
Domain	SUSHI	CFH CFHR3	1.06e-02	56	52	2	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CFHR3	1.10e-02	57	52	2	IPR000436
Pubmed	Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.	USP9X PEX5	2.46e-06	2	55	2	22371489
Pubmed	Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.	CFH CFHR3	2.46e-06	2	55	2	20694013
Pubmed	Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells.	CFH CFHR3	2.46e-06	2	55	2	34819935
Pubmed	The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern.	MEGF11 MEGF10	2.46e-06	2	55	2	17498693
Pubmed	A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H-Related 3 Gene in Atypical Hemolytic Uremic Syndrome.	CFH CFHR3	2.46e-06	2	55	2	26490391
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	SORT1 KNTC1 TTBK2 SFSWAP ARHGEF7 USP9X CSNK2A2 SMARCC1 DDX23 EIPR1 DEGS1	4.47e-06	1284	55	11	17353931
Pubmed	Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.	CFH CFHR3	7.36e-06	3	55	2	20581873
Pubmed	Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.	CFH CFHR3	7.36e-06	3	55	2	26163426
Pubmed	Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.	CFH CFHR3	7.36e-06	3	55	2	10781834
Pubmed	Association assessment of copy number polymorphism and risk of age-related macular degeneration.	CFH CFHR3	7.36e-06	3	55	2	21856016
Pubmed	Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.	CFH CFHR3	7.36e-06	3	55	2	25205734
Pubmed	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.	CFH CFHR3	7.36e-06	3	55	2	18006700
Pubmed	Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.	CFH CFHR3	7.36e-06	3	55	2	19531976
Pubmed	Assessment of PPARGC1A, PPARGC1B, and PON1 Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case-Control Study Involving 2351 Subjects.	PPARGC1B PON1	7.36e-06	3	55	2	32721231
Pubmed	Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.	CFH CFHR3	7.36e-06	3	55	2	26942649
Pubmed	An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).	CFH CFHR3	7.36e-06	3	55	2	20843825
Pubmed	Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.	CFH CFHR3	7.36e-06	3	55	2	22848687
Pubmed	A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.	CFH CFHR3	7.36e-06	3	55	2	32321835
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFH CFHR3	7.36e-06	3	55	2	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFH CFHR3	7.36e-06	3	55	2	25684976
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1A KIF1C	7.36e-06	3	55	2	23404705
Pubmed	Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology.	PECR PEX5	7.36e-06	3	55	2	11669066
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFH CFHR3	1.47e-05	4	55	2	24333077
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST3 NDST4	1.47e-05	4	55	2	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST3 NDST4	1.47e-05	4	55	2	12070138
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFH CFHR3	1.47e-05	4	55	2	36793547
Pubmed	Complement factor H and related proteins: an expanding family of complement-regulatory proteins?	CFH CFHR3	2.45e-05	5	55	2	8172644
Pubmed	Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.	CFH CFHR3	2.45e-05	5	55	2	1689298
Pubmed	TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.	PECR PEX5	2.45e-05	5	55	2	28724525
Pubmed	Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.	CFH CFHR3	2.45e-05	5	55	2	20042240
Pubmed	A radiation hybrid map of complement factor H and factor H-related genes.	CFH CFHR3	2.45e-05	5	55	2	10380701
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST3 NDST4	2.45e-05	5	55	2	11087757
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFH CFHR3	3.67e-05	6	55	2	27196323
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFH CFHR3	3.67e-05	6	55	2	17438673
Pubmed	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration.	CFH CFHR3	3.67e-05	6	55	2	24557084
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SFSWAP CSNK2A2 SAP30BP SMARCC1 DDX23	4.88e-05	251	55	5	31076518
Pubmed	Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor.	MEGF11 MEGF10	5.13e-05	7	55	2	19915564
Pubmed	The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.	CSNK2A2 KIF1C	5.13e-05	7	55	2	10559254
Pubmed	Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.	CFH CFHR3	5.13e-05	7	55	2	19861685
Pubmed	Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.	NDST3 INTU	5.13e-05	7	55	2	21948523
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	PCSK1 CFH CEL AACS HABP2 FOXA1 KIF1C	5.57e-05	624	55	7	18554416
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTU SFSWAP ZNF827 CSNK2A2 SAP30BP PEX5 SMARCC1 FOXA1 BRWD3	5.89e-05	1116	55	9	31753913
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST3 NDST4	6.83e-05	8	55	2	24067353
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A KIF1C	6.83e-05	8	55	2	25818806
Pubmed	Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.	CFH PON1 IGLV3-21 CFHR3	7.94e-05	143	55	4	22516433
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFH CFHR3	8.78e-05	9	55	2	20059470
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFH CFHR3	8.78e-05	9	55	2	28533443
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PPARGC1B INTU SHC2 IL17REL KIF1A CACNA2D2 ZNF827 EIPR1 MAPK6 BRWD3	1.01e-04	1489	55	10	28611215
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST3 NDST4	1.34e-04	11	55	2	15944372
Pubmed	Genetic Atypical Hemolytic-Uremic Syndrome	CFH CFHR3	1.34e-04	11	55	2	20301541
Pubmed	Hereditary Spastic Paraplegia Overview	KIF1A DDHD1 KIF1C	1.39e-04	63	55	3	20301682
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST3 NDST4	1.60e-04	12	55	2	12460940
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	CFH PON1	2.21e-04	14	55	2	19015224
Pubmed	Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.	MEGF11 MEGF10	2.54e-04	15	55	2	31812516
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	USP9X SMARCC1	2.90e-04	16	55	2	35390516
Pubmed	The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function.	USP9X DEGS1	2.90e-04	16	55	2	9817915
Pubmed	Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.	CFH CFHR3	3.29e-04	17	55	2	23028341
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	CSNK2A2 SAP30BP KHDRBS2 SMARCC1 DDX23	3.79e-04	390	55	5	17643375
Pubmed	Genome-wide association study identifies susceptibility loci for IgA nephropathy.	CFH CFHR3	4.13e-04	19	55	2	21399633
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST3 NDST4	4.58e-04	20	55	2	17107998
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST3 NDST4	5.56e-04	22	55	2	19299468
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	ARHGEF7 USP9X CSNK2A2 SAP30BP RIOK2	6.03e-04	432	55	5	23455922
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	NDST3 INTU PECR KIF1A EIPR1	6.69e-04	442	55	5	15815621
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1A KIF1C	7.20e-04	25	55	2	9275178
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	PECR PEX5	7.79e-04	26	55	2	30378028
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SFSWAP USP9X CSNK2A2 SAP30BP MRPS33 DDX23	8.98e-04	713	55	6	29802200
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	PECR PEX5	9.04e-04	28	55	2	22002062
Pubmed	The small GTPase RSG1 controls a final step in primary cilia initiation.	TTBK2 INTU	9.04e-04	28	55	2	29038301
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PECR SFSWAP CSNK2A2 SAP30BP MRPS33 SMARCC1 DDX23 RIOK2	1.34e-03	1371	55	8	36244648
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	USP9X CSNK2A2 DDX23	1.38e-03	138	55	3	37506885
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	MEGF11 MEGF10	1.41e-03	35	55	2	22407321
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF1A KIF1C	1.58e-03	37	55	2	11416179
Cytoband	12q24.31	KNTC1 CFAP251 AACS RNF10	2.72e-06	80	55	4	12q24.31
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	KNTC1 CFAP251 SFSWAP AACS RNF10	1.41e-04	415	55	5	chr12q24
Cytoband	4q26	NDST3 NDST4	1.29e-03	44	55	2	4q26
Cytoband	1q32	CFH CFHR3	1.60e-03	49	55	2	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chr4q26	NDST3 NDST4	2.01e-03	55	55	2	chr4q26
Cytoband	Ensembl 112 genes in cytogenetic band chr5q15	PCSK1 RIOK2	2.31e-03	59	55	2	chr5q15
Cytoband	1p13.3	SORT1 ERVK11-1	3.14e-03	69	55	2	1p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH CFHR3	3.70e-03	75	55	2	chr1q31
GeneFamily	Complement system\|Sushi domain containing	CFH CFHR3	3.01e-03	36	41	2	492
GeneFamily	Sulfotransferases, membrane bound	NDST3 NDST4	3.18e-03	37	41	2	763
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1A KIF1C	4.88e-03	46	41	2	622
GeneFamily	X-linked mental retardation\|Angiotensin receptors	USP9X BRWD3	6.43e-03	53	41	2	103
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CFHR3	7.40e-03	57	41	2	1179
Drug	(2S)-N-[4-(aminomethyl)-1,1-dioxothian-4-yl]-2-[1-(benzenesulfonamido)ethylideneamino]-3-(1-methylcyclopentyl)propanamide	CFH CFHR3	5.12e-06	2	52	2	CID011840931
Drug	Cholesterol, LDL	SORT1 PPARGC1B PON1	7.47e-06	17	52	3	ctd:D008078
Disease	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase measurement	CFH PON1 CFHR3	5.16e-09	3	52	3	EFO_0801568
Disease	transcription regulator protein BACH2 measurement	CFH PON1	3.05e-06	2	52	2	EFO_0803164
Disease	carbonic anhydrase 5A, mitochondrial measurement	CFH PON1	3.05e-06	2	52	2	EFO_0801450
Disease	interferon gamma receptor 1 measurement	CFH HABP2	3.05e-06	2	52	2	EFO_0020484
Disease	anaphase-promoting complex subunit 7 measurement	CFH CFHR3	9.13e-06	3	52	2	EFO_0801381
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	9.13e-06	3	52	2	C2749604
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	9.13e-06	3	52	2	235400
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFH CFHR3	9.13e-06	3	52	2	cv:C2749604
Disease	E3 ISG15--protein ligase HERC5 measurement	CFH PON1	9.13e-06	3	52	2	EFO_0802501
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR3	1.82e-05	4	52	2	EFO_0803292
Disease	E3 ubiquitin-protein ligase RNF8 measurement	CFH PON1	1.82e-05	4	52	2	EFO_0801557
Disease	B-cell antigen receptor complex-associated protein alpha chain measurement	CFH PON1	1.82e-05	4	52	2	EFO_0801402
Disease	NAD-dependent protein deacylase sirtuin-5, mitochondrial measurement	CFH PON1	1.82e-05	4	52	2	EFO_0801822
Disease	Meningococcal Infections	CFH CFHR3	1.82e-05	4	52	2	C0025303
Disease	E3 ubiquitin-protein ligase NEURL1 measurement	CFH PON1	3.04e-05	5	52	2	EFO_0801554
Disease	lysophosphatidylcholine acyltransferase 2 measurement	CFH HABP2	3.04e-05	5	52	2	EFO_0801775
Disease	Membranoproliferative Glomerulonephritis, Type I	CFH PON1	4.55e-05	6	52	2	C0268742
Disease	Membranoproliferative Glomerulonephritis, Type II	CFH PON1	4.55e-05	6	52	2	C0268743
Disease	transmembrane protein 59-like measurement	CFH PON1	4.55e-05	6	52	2	EFO_0802157
Disease	Membranoproliferative Glomerulonephritis, Type III	CFH PON1	4.55e-05	6	52	2	C1720821
Disease	keratinocyte differentiation-associated protein measurement	CFH PON1	6.36e-05	7	52	2	EFO_0801743
Disease	Glomerulonephritis, Membranoproliferative	CFH PON1	6.36e-05	7	52	2	C0017662
Disease	cytoskeleton-associated protein 2 measurement	CFH PON1	8.47e-05	8	52	2	EFO_0020309
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFHR3	8.47e-05	8	52	2	DOID:0080301 (is_implicated_in)
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR3	1.09e-04	9	52	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR3	1.09e-04	9	52	2	cv:C0019061
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFHR3	1.36e-04	10	52	2	C2931788
Disease	gastrin-releasing peptide measurement	CFH HABP2	1.66e-04	11	52	2	EFO_0022000
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1C	1.99e-04	12	52	2	DOID:863 (implicated_via_orthology)
Disease	SLAM family member 7 measurement	CFH DDR2	4.07e-04	17	52	2	EFO_0008287
Disease	Age-related macular degeneration	CFH CFHR3	4.58e-04	18	52	2	cv:C0242383
Disease	aspartate aminotransferase measurement	PCSK1 CFH CEL CACNA2D2 ZNF827 KHDRBS2 CFHR3	9.96e-04	904	52	7	EFO_0004736
Disease	macular degeneration (is_implicated_in)	CFH PON1	1.04e-03	27	52	2	DOID:4448 (is_implicated_in)
Disease	azoospermia (implicated_via_orthology)	NDST3 NDST4	1.04e-03	27	52	2	DOID:14227 (implicated_via_orthology)
Disease	osteoarthritis (is_implicated_in)	DDR2 TNFRSF11B	1.12e-03	28	52	2	DOID:8398 (is_implicated_in)
Disease	Age related macular degeneration	CFH CFHR3	1.28e-03	30	52	2	C0242383
Disease	angina pectoris	CFH EIPR1 BRWD3	1.41e-03	125	52	3	EFO_0003913
Disease	Diabetes Mellitus	KIF1A PON1	1.46e-03	32	52	2	C0011849
Disease	Complement deficiency disease	CFH CFHR3	1.55e-03	33	52	2	C0272242
Disease	nicotine withdrawal symptom count	KIF1A DDR2	1.75e-03	35	52	2	EFO_0009263
Disease	sleep measurement	NDST3 CACNA2D2 KIF1C	1.76e-03	135	52	3	EFO_0004870

Protein segments in the cluster

Peptide	Gene	Start	Entry
WGHYSGDEEDAYSAE	CCR10	11	P46092
TYFISYWEDEDHHPT	ERVK11-1	151	P61568
YHSWFQADPAEAEGS	CACNA2D2	991	Q9NY47
SYDDLYHWSVESYSD	AACS	46	Q86V21
EYPDSSFQCYSVHWD	BRWD3	1076	Q6RI45
SEDSDYDSIWTAHSY	ARHGEF7	771	Q14155
YCDEHFETPSGSYWD	CFH	356	P08603
THWEPYTTENSGYLE	CEL	506	P19835
YAWYEERDTLAHSAP	CFAP251	421	Q8TBY9
AYSWYQHQRSHEDPA	NDST3	701	O95803
QPEDEADYYCGTWHS	IGLV5-52	106	A0A0A0MRZ9
HWESYSVTVQESYPH	MEGF10	36	Q96KG7
WESYAVTVQESYAHP	MEGF11	31	A6BM72
WDYTDHVWTEVYSPS	NGLY1	331	Q96IV0
EVLWDTVYYHPESQT	IL17REL	206	Q6ZVW7
DFTQTHEYHVWPGYD	DDR2	241	Q16832
SWSSSEPCLEDYYHI	FNDC9	16	Q8TBE3
DTNYSTEPCWQYSDH	MAPK6	416	Q16659
HPWLSDYDDLTSATY	PEX5	306	P50542
SLYTHSYEVPDHDNW	PECR	266	Q9BY49
TFDYSYWSHTSTEDP	KIF1C	51	O43896
EADYYCQVWDSSSDH	IGLV3-21	101	P80748
FGTHKDPYEEWSYSD	KNTC1	1181	P50748
YSWYQHQRSHEDPAA	NDST4	701	Q9H3R1
YPVYQDYHTVWESEE	COMMD8	36	Q9NX08
WDASEDTSIDYNPLY	DDX23	276	Q9BUQ8
ATYEEHEDSVYAVDW	EIPR1	341	Q53HC9
YSSASSDYDDLEPEW	INTU	41	Q9ULD6
ETSDWNSYYADTQEA	FOXA1	11	P55317
HAENPDWYYTEDQAD	HABP2	61	Q14520
LDSCYWDHKEAPYSD	ANP32C	141	O43423
DEHFETPSGSYWDYI	CFHR3	56	Q02985
SVTQPWYLEVDYTHE	IGSF6	31	O95976
SHWCYEVQAESSNYP	CA4	21	P22748
SREDFEWVYTDQPHA	DEGS1	6	O15121
DYEAHVPSWGNQDDY	CSNK2A2	26	P19784
EDAYDSYAPEEWATT	KHDRBS2	311	Q5VWX1
SNTPEEHTAYIWDYF	FAM172BP	206	A6NC97
WHSVDEVYLYSDATT	DDHD1	351	Q8NEL9
SFDYSYWSHTSPEDI	KIF1A	51	Q12756
KETYDWYPNHHTYAE	MRPS33	46	Q9Y291
SYYTHRHGNPEEEEW	USP9X	366	Q93008
DYTIWLAHSTDPEDY	SORT1	616	Q99523
HDLSEYDAEYSTWNR	SFSWAP	81	Q12872
TNDHYFLDPYLQSWE	PON1	181	P27169
HFCWPRYTDYDSNSE	PPARGC1B	981	Q86YN6
YPDSYDTWVHSNDVD	SMARCC1	236	Q92922
PDHYYTDSWHTSDEC	TNFRSF11B	66	O00300
AWGDEEDSLEHNYYN	SHC2	326	P98077
YTAHFADPDTLVNWD	RNF10	196	Q8N5U6
TDHIWHYDEEYLPDA	TTBK2	501	Q6IQ55
FDPHGWSEDSYYEAL	SAP30BP	186	Q9UHR5
VSTSHPNAEWYFDRD	RIOK2	251	Q9BVS4
HWYGNSSETPSEASY	ZNF827	31	Q17R98
SYSQPSDSWDKDYDS	TWF1	41	Q12792
PWDVNAYYSVSDHVV	KEL	536	P23276
EWNHTDIYANYDPEA	PCSK1	171	P29120