Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	JUP DSP	7.68e-05	5	56	2	GO:0086083
HumanPheno	Syndactyly	CUL4B JUP DDX59 DSP DYNC2H1 APC NBN CNOT2	1.35e-05	417	16	8	HP:0001159
HumanPheno	Absent toenail	JUP DSP APC	2.39e-05	19	16	3	HP:0001802
HumanPheno	Congenital alopecia totalis	JUP DSP	2.77e-05	3	16	2	HP:0005597
HumanPheno	3-4 finger osseus syndactyly	JUP DSP	9.20e-05	5	16	2	HP:0006097
HumanPheno	4-5 finger cutaneous syndactyly	JUP DSP	9.20e-05	5	16	2	HP:0010705
HumanPheno	Hypovolemic shock	JUP DSP	9.20e-05	5	16	2	HP:0031274
HumanPheno	Supernumerary tooth	JUP DDX59 DSP APC	1.13e-04	85	16	4	HP:0011069
HumanPheno	Osseous finger syndactyly	JUP DSP	1.38e-04	6	16	2	HP:0010492
HumanPheno	Sandal gap	CUL4B DDX59 DSP NBN	1.81e-04	96	16	4	HP:0001852
HumanPheno	Right ventricular cardiomyopathy	JUP DSP	1.92e-04	7	16	2	HP:0011663
HumanPheno	Absent fingernail	JUP DSP APC	2.34e-04	40	16	3	HP:0001817
HumanPheno	Intermittent jaundice	SPTB SLCO1B3	3.29e-04	9	16	2	HP:0001046
HumanPheno	Acantholysis	JUP DSP	4.10e-04	10	16	2	HP:0100792
HumanPheno	Impaired myocardial contractility	JUP DSP	4.10e-04	10	16	2	HP:0006670
HumanPheno	Abnormal 5th finger morphology	CUL4B JUP DDX59 DSP DYNC2H1 CNOT2 ZNF292	4.89e-04	509	16	7	HP:0004207
HumanPheno	2-3 finger cutaneous syndactyly	JUP DSP	5.00e-04	11	16	2	HP:0001233
HumanPheno	Abnormal dermoepidermal hemidesmosome morphology	JUP DSP	5.00e-04	11	16	2	HP:0032449
HumanPheno	Abnormal toe morphology	CUL4B JUP DDX59 DSP DYNC2H1 APC NBN CNOT2 RYR3	5.29e-04	893	16	9	HP:0001780
HumanPheno	Abnormal dermoepidermal junction morphology	JUP DSP	5.99e-04	12	16	2	HP:0031538
Domain	TUDOR	TDRD5 PHF20L1	2.15e-03	23	56	2	PS50304
Domain	TUDOR	TDRD5 PHF20L1	2.95e-03	27	56	2	SM00333
Domain	Spectrin_repeat	DSP SPTB	3.40e-03	29	56	2	IPR002017
Domain	Tudor	TDRD5 PHF20L1	3.64e-03	30	56	2	IPR002999
Domain	Arm	JUP APC	3.88e-03	31	56	2	PF00514
Domain	Spectrin/alpha-actinin	DSP SPTB	4.13e-03	32	56	2	IPR018159
Domain	SPEC	DSP SPTB	4.13e-03	32	56	2	SM00150
Domain	ARM_REPEAT	JUP APC	6.40e-03	40	56	2	PS50176
Domain	ARM	JUP APC	6.40e-03	40	56	2	SM00185
Domain	Armadillo	JUP APC	8.75e-03	47	56	2	IPR000225
Pathway	WP_ENDODERM_DIFFERENTIATION	CUL4B BMP7 PARP8 APC CDYL FOXN3	2.43e-06	143	39	6	M39591
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	JUP ZZZ3 DSP ZSCAN4 ZBTB21 APC GOLGA5 PCM1	3.49e-07	418	56	8	34709266
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DSP RBL2 SPTB APC DNM3 CIPC NR1H2 USP54 CNOT2 PCM1 RYR3 ZNF292	7.62e-07	1285	56	12	35914814
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CUL4B SYTL2 APC NBN QSER1 USP54 GOLGA5 CNOT2 PCM1	2.44e-06	733	56	9	34672954
Pubmed	Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.	APC NBN	2.55e-06	2	56	2	19584276
Pubmed	The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.	JUP DSP	2.55e-06	2	56	2	9348293
Pubmed	Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells.	CUL4B APC	2.55e-06	2	56	2	38761506
Pubmed	Premature Termination Codon in 5' Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation.	JUP DSP	2.55e-06	2	56	2	35054841
Pubmed	PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.	KCND2 PCM1 RYR3	5.15e-06	21	56	3	39304345
Pubmed	VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.	JUP DSP	7.63e-06	3	56	2	9739078
Pubmed	Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.	JUP DSP	7.63e-06	3	56	2	16823493
Pubmed	Plakoglobin is required for effective intermediate filament anchorage to desmosomes.	JUP DSP	7.63e-06	3	56	2	18496566
Pubmed	The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.	JUP DSP	7.63e-06	3	56	2	24276085
Pubmed	Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.	JUP APC	7.63e-06	3	56	2	11707392
Pubmed	Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.	JUP DSP	7.63e-06	3	56	2	25225338
Pubmed	Three-dimensional structure of the armadillo repeat region of beta-catenin.	JUP APC	7.63e-06	3	56	2	9298899
Pubmed	Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer.	JUP DSP	1.52e-05	4	56	2	22515648
Pubmed	Crystal structure of a beta-catenin/Tcf complex.	JUP APC	1.52e-05	4	56	2	11136974
Pubmed	Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.	JUP APC	1.52e-05	4	56	2	8074697
Pubmed	Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy.	JUP DSP	1.52e-05	4	56	2	22889254
Pubmed	The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.	JUP APC	1.52e-05	4	56	2	11348595
Pubmed	The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein.	JUP DSP	1.52e-05	4	56	2	12426320
Pubmed	Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.	JUP DSP	1.52e-05	4	56	2	8858175
Pubmed	Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy.	JUP DSP	1.52e-05	4	56	2	23381804
Pubmed	Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin.	JUP DSP	1.52e-05	4	56	2	20525856
Pubmed	Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.	JUP DSP	2.54e-05	5	56	2	22781308
Pubmed	The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.	JUP APC	2.54e-05	5	56	2	7651399
Pubmed	Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.	CUL4B APC	2.54e-05	5	56	2	19651607
Pubmed	Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.	JUP DSP	2.54e-05	5	56	2	16917092
Pubmed	Defining the interactions between intermediate filaments and desmosomes.	JUP DSP	2.54e-05	5	56	2	9606214
Pubmed	The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.	JUP APC	2.54e-05	5	56	2	7890674
Pubmed	Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy.	JUP DSP	2.54e-05	5	56	2	20864495
Pubmed	Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.	BMP7 FOXN3	2.54e-05	5	56	2	20691664
Pubmed	Expression and interaction of different catenins in colorectal carcinoma cells.	JUP APC	2.54e-05	5	56	2	11712088
Pubmed	The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners.	JUP DSP	2.54e-05	5	56	2	19136012
Pubmed	Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.	JUP DSP	2.54e-05	5	56	2	20031617
Pubmed	Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).	JUP DSP	2.54e-05	5	56	2	1889810
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	JUP ZZZ3 SMG7 DSP NBN QSER1 PCM1	2.79e-05	549	56	7	38280479
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	JUP SMG7 APC USP54 PCM1	3.23e-05	226	56	5	25900982
Pubmed	Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.	APC ZNF292	3.80e-05	6	56	2	25559195
Pubmed	E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.	JUP DSP	3.80e-05	6	56	2	20859650
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZZZ3 SMG7 DSP DYNC2H1 APC NBN PCM1	4.31e-05	588	56	7	38580884
Pubmed	Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.	JUP DSP	5.32e-05	7	56	2	15479741
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CUL4B SMG7 DSP APC NBN USP54 GOLGA5 PCM1	6.36e-05	853	56	8	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	PHF20L1 DSP RBL2 SMARCAL1 ZBTB21 FOXN3 QSER1 ADGRL2	6.57e-05	857	56	8	25609649
Pubmed	CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart.	JUP DSP	7.09e-05	8	56	2	36577382
Pubmed	Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.	JUP DSP	7.09e-05	8	56	2	20093627
Pubmed	Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation.	JUP DSP	7.09e-05	8	56	2	10801826
Pubmed	Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage.	JUP DSP	7.09e-05	8	56	2	9864371
Pubmed	The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.	CUL4B NBN	9.10e-05	9	56	2	33524014
Pubmed	Arrhythmogenic Right Ventricular Cardiomyopathy Overview	JUP DSP	1.14e-04	10	56	2	20301310
Pubmed	A balance between elongation and trimming regulates telomere stability in stem cells.	SMARCAL1 NBN	1.14e-04	10	56	2	27918544
Pubmed	Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.	JUP DSP	1.14e-04	10	56	2	29959233
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL4B SMG7 CTDSPL2 SHCBP1 ZBTB21 APC SEPTIN11	1.16e-04	689	56	7	36543142
Pubmed	Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.	JUP DSP	1.39e-04	11	56	2	21844209
Pubmed	Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.	JUP DSP	1.39e-04	11	56	2	11790773
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	JUP DSP	1.39e-04	11	56	2	27766308
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	CUL4B SMG7 ADGRL2 PCM1	1.62e-04	169	56	4	31462741
Pubmed	Defining desmosomal plakophilin-3 interactions.	JUP DSP	1.66e-04	12	56	2	12707304
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	JUP DSP	1.96e-04	13	56	2	14673151
Pubmed	Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects.	JUP DSP	2.29e-04	14	56	2	17766470
Pubmed	Perp is a p63-regulated gene essential for epithelial integrity.	JUP DSP	2.29e-04	14	56	2	15797384
Pubmed	Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.	JUP DSP	2.64e-04	15	56	2	9847250
Pubmed	p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.	JUP DSP	2.64e-04	15	56	2	23108156
Pubmed	Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	CUL4B PHF20L1	2.64e-04	15	56	2	29691401
Pubmed	Partial transcriptome of the developing pituitary gland.	APC NBN	3.01e-04	16	56	2	11161784
Pubmed	Desmocollin 3 is required for pre-implantation development of the mouse embryo.	JUP DSP	3.01e-04	16	56	2	16418220
Pubmed	RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.	JUP DSP	3.01e-04	16	56	2	30689641
Pubmed	beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.	BMP7 JUP	3.41e-04	17	56	2	11371349
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	JUP APC	3.41e-04	17	56	2	17510365
Pubmed	Desmoplakin is essential in epidermal sheet formation.	JUP DSP	3.41e-04	17	56	2	11781569
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	DSP CENPI CDYL PCM1	3.71e-04	210	56	4	16565220
Pubmed	A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.	CTDSPL2 DSP	3.83e-04	18	56	2	26674342
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CUL4B ZZZ3 SMG7 ZBTB21 NBN USP54 ADGRL2 PCM1	3.97e-04	1116	56	8	31753913
Pubmed	Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.	JUP APC	4.28e-04	19	56	2	17002498
Pubmed	Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.	CUL4B PHF20L1	4.28e-04	19	56	2	30442713
Pubmed	Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.	APC CDYL	4.28e-04	19	56	2	23332759
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PHF20L1 CTDSPL2 ZBTB21 CDYL QSER1 ZNF292	4.31e-04	608	56	6	36089195
Pubmed	Human transcription factor protein interaction networks.	JUP ZZZ3 SMG7 ZBTB21 NBN QSER1 USP54 CNOT2 PCM1	4.32e-04	1429	56	9	35140242
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JUP DSP PARP8 ZBTB21 APC USP54 PCM1	4.49e-04	861	56	7	36931259
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	DYNC2H1 RBL2 APC USP54 ZNF292	4.53e-04	398	56	5	35016035
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	APC HEATR5B	4.75e-04	20	56	2	21689717
Pubmed	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.	JUP APC	4.75e-04	20	56	2	7806582
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZZZ3 RBL2 ZSCAN4 APC NR1H2 CNOT2 ZNF292	5.01e-04	877	56	7	20211142
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	TCP10L PHF20L1 FOXN3 RASGRP2	5.23e-04	230	56	4	29513927
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	SMARCAL1 ETAA1	5.24e-04	21	56	2	27723720
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	KCND2 RASGRP2	5.76e-04	22	56	2	26494785
Pubmed	Role of β-catenin in development of bile ducts.	JUP APC	6.30e-04	23	56	2	26856660
Pubmed	New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.	JUP DSP	6.30e-04	23	56	2	18809908
Pubmed	The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus.	BMP7 JUP	6.30e-04	23	56	2	21600200
Pubmed	Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.	BMP7 APC	6.30e-04	23	56	2	14623818
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	SMG7 CENPI GOLGA5 PCM1	7.25e-04	251	56	4	29778605
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	JUP SMG7 DSP ZBTB21 NBN GOLGA5 PCM1	7.27e-04	934	56	7	33916271
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	JUP DSP	7.46e-04	25	56	2	23132931
Pubmed	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.	SMARCAL1 ETAA1	7.46e-04	25	56	2	32528060
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	JUP DSP APC PCM1	7.80e-04	256	56	4	33397691
Pubmed	Epidermal development requires ninein for spindle orientation and cortical microtubule organization.	JUP DSP	8.07e-04	26	56	2	30923192
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CUL4B JUP ZZZ3 DSP NBN QSER1 PCM1	8.23e-04	954	56	7	36373674
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SMG7 APC USP54 GOLGA5	8.62e-04	263	56	4	34702444
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	JUP DSP USP54 PCM1	8.74e-04	264	56	4	32814769
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZZZ3 NR1H2 FOXN3 NFAT5 CNOT2 ZNF292	9.60e-04	709	56	6	22988430
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	CUL4B BMP7 ZZZ3 PHF20L1 ETAA1 APC NBN QSER1 PCM1	9.67e-06	656	56	9	M18979
Coexpression	GAVIN_FOXP3_TARGETS_CLUSTER_P2	BMP7 DSP FOXN3 PCM1	2.75e-05	81	56	4	M1732
Coexpression	GAVIN_FOXP3_TARGETS_CLUSTER_P2	BMP7 DSP FOXN3 PCM1	3.65e-05	87	56	4	MM724
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	CUL4B RBL2 SMARCAL1 APC SEPTIN11 NBN CDYL NFAT5 CREBL2 PCM1 RYR3	4.42e-05	1215	56	11	M41122
Coexpression	GSE25890_CTRL_VS_IL33_IL7_TREATED_NUOCYTES_DN	ZZZ3 ETAA1 NBN CNOT2 PCM1	6.85e-05	200	56	5	M7356
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	ZZZ3 CTDSPL2 APC NBN QSER1 HEATR5B CNOT2 PCM1 ZNF292	1.32e-05	564	55	9	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	CUL4B ZNF800 DDX59 CTDSPL2 CENPI ETAA1 APC NBN CIPC QSER1 CEP126 PCM1 ZNF292	1.45e-05	1257	55	13	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	PHF20L1 CENPI ETAA1 APC CEP126 HEATR5B CNOT2 ZNF292	2.61e-05	469	55	8	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	CUL4B ZNF800 DDX59 CTDSPL2 CENPI ETAA1 APC NBN CIPC QSER1 CEP126 PCM1 ZNF292	6.88e-05	1459	55	13	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	CUL4B BMP7 ZNF800 CTDSPL2 CENPI ETAA1 APC CDYL QSER1 CEP126 PCM1 ZNF292	6.91e-05	1252	55	12	facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TDRD5 TTC16 DYNC2H1 CEP126 TXK	2.31e-06	169	56	5	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PARP8 SYTL2 PCM1 ZNF292 TXK	5.12e-06	199	56	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	COVID-19_Mild-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	LRRC75B CENPI GOLGA5 TXK	2.91e-05	140	56	4	b1429028c52f84127b894b93b55961badcd5246f
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RBM44 PARP8 CEP126 TXK	4.12e-05	153	56	4	d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 RBL2 SYTL2 TXK	4.33e-05	155	56	4	c58a5fb8d853f12204e961d633e83452eb12a659
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 RBL2 SYTL2 TXK	4.33e-05	155	56	4	9cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCell	Adult-Immune-natural_killer_cell-D122\|Adult / Lineage, Cell type, age group and donor	TTC16 PARP8 SYTL2 TXK	5.79e-05	167	56	4	ff1ce3b1a2d91d2ad979f25899db4f4eeb865892
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	RBM44 GOLGA5 HEATR5B ZNF292	5.92e-05	168	56	4	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBL2 PARP8 SYTL2 TXK	6.06e-05	169	56	4	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 SYTL2 CEP126 NSUN7	6.06e-05	169	56	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BMP7 RBM44 SHCBP1 SEPTIN11	6.20e-05	170	56	4	6b91d4cbe0697b65bfb2e099e7a9b39ea2fba3a9
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TTC16 PARP8 RASGRP2 TXK	6.78e-05	174	56	4	33d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JUP DSP SYTL2 USP54	7.57e-05	179	56	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG DSP SPTB ITPRID1	8.25e-05	183	56	4	877559962b2b073fc2a9f1b64a76e17895e40a97
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DSP SPTB CENPI ITPRID1	8.42e-05	184	56	4	204d16c48f822c98dc4118ac97a4f99f7e1163c8
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTDSPL2 APC SEPTIN11 PCM1	8.42e-05	184	56	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DSP SPTB CENPI ITPRID1	8.42e-05	184	56	4	9365cdc52a2419e3f27e1c1c9310fa707d1e506b
ToppCell	droplet-Lung-nan-21m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP SPTB CENPI ITPRID1	8.42e-05	184	56	4	7cc3b9bba1f600b40b02fe2456b5d007dbf9fa37
ToppCell	droplet-Lung-nan-21m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP SPTB CENPI ITPRID1	8.42e-05	184	56	4	53b71c4ac86dc5e42763b8f64fbc917177531017
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMP7 SPTB SEPTIN11 RYR3	8.96e-05	187	56	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG DSP SPTB DNM3	9.15e-05	188	56	4	c300accbac71a3bc075fe985543d8a8ead82531b
ToppCell	Control-Lymphoid-ILC_A\|Control / Disease state, Lineage and Cell class	PARP8 SYTL2 CNOT2 TXK	9.73e-05	191	56	4	1ca73582dc3d28322b5ee841010067589d848acc
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 DSP SPTB RYR3	9.73e-05	191	56	4	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 DSP SPTB RYR3	9.73e-05	191	56	4	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	URO-Lymphocyte-T_NK-CD8_TEM\|URO / Disease, Lineage and Cell Type	TTC16 RBL2 PARP8 SYTL2	9.92e-05	192	56	4	31b6d068f7adc6952c4cf625df851a10cb1b00c9
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	DSP NFAT5 PCM1 ZNF292	9.92e-05	192	56	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RBL2 PARP8 SYTL2 TXK	1.01e-04	193	56	4	544de0988510cc57744710d7cafe07aa27a0b99d
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	DSP NFAT5 PCM1 ZNF292	1.01e-04	193	56	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DYNC2H1 ZBTB21 CEP126 PCM1	1.03e-04	194	56	4	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	COVID-19-lung-NK_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TTC16 PARP8 RASGRP2 TXK	1.03e-04	194	56	4	4c92f18e0a34fb50630d4b260eaf179202508b6d
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 SPTB DNM3 ADGRL2	1.03e-04	194	56	4	e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCND2 SPTB DNM3 ADGRL2	1.03e-04	194	56	4	4b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RBL2 PARP8 SYTL2 TXK	1.05e-04	195	56	4	caa3669739974b63470f7e557df96e8d3844dd84
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-SELL+_CD8_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TTC16 PARP8 RASGRP2 TXK	1.05e-04	195	56	4	82561f6ed75ee33c2581fb25bd0997a9f0538cd8
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RBL2 PARP8 SYTL2 TXK	1.05e-04	195	56	4	bc5728e9df0b15adec50a7c840ce9f2775135087
ToppCell	COVID-19-lung-NK_cells\|lung / Disease (COVID-19 only), tissue and cell type	TTC16 PARP8 RASGRP2 TXK	1.05e-04	195	56	4	3b716ec7acc9a37af6bf40e711a539ce58d74aa4
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	TTC16 RBL2 PARP8 SYTL2	1.05e-04	195	56	4	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	093fb240e72911dfd360aa6edf8ed2d611c78a1e
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYTL2 ETAA1 RASGRP2 TXK	1.07e-04	196	56	4	c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	0f3c7fd450aaa1f866b8558692534c0ea2a34e75
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	c06caba0c91b8ee66f42bc43ec75eb2475f07056
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	4e1f8828413896ab8a4ec92a89d6789e8e37e05a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.07e-04	196	56	4	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RBL2 PARP8 SYTL2 TXK	1.07e-04	196	56	4	c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	2b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_Tem\|COVID-19_Severe / Disease group, lineage and cell class	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYTL2 PCM1 ZNF292 TXK	1.10e-04	197	56	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TTC16 RBL2 PARP8 PCM1	1.10e-04	197	56	4	2e9677b4b9a7c88db16416e5f114a2031ec3bc24
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TTC16 RBL2 PARP8 PCM1	1.10e-04	197	56	4	4c9919914079e76b1d2220b249e0d0b0d9bf4bc0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	e70e7d97823a762def3970d94a0e897981a6c922
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCell	COVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TTC16 RBL2 PARP8 SYTL2	1.10e-04	197	56	4	d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive_helper_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBL2 PARP8 RASGRP2 TXK	1.12e-04	198	56	4	c4d8d133e571ad3a7c5de93aa7befb67cb7a003d
ToppCell	COVID-19_Moderate-CD8+_Tem\|World / disease group, cell group and cell class	TTC16 RBL2 PARP8 SYTL2	1.12e-04	198	56	4	1d12be256af028c88e31fb535068bae16b7bd48e
ToppCell	T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RBL2 PARP8 SYTL2 TXK	1.12e-04	198	56	4	1ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBL2 PARP8 RASGRP2 TXK	1.12e-04	198	56	4	db107a5511571384f26e26c6301aef9a9f2423c4
ToppCell	COVID-19_Moderate-CD4+_CTL\|World / disease group, cell group and cell class	TTC16 RBL2 PARP8 SYTL2	1.14e-04	199	56	4	12ea0346b4da3e8e2b3b2b3b3e9d4f4f104345a6
ToppCell	COVID-19-Lymphoid-CD4_T_cells\|COVID-19 / Condition, Lineage and Cell class	RBL2 PARP8 SYTL2 TXK	1.14e-04	199	56	4	27ac7ad2f4c2028c355632cbb81f2b52439b85ad
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Severe / Disease, condition lineage and cell class	TTC16 RBL2 PARP8 SYTL2	1.16e-04	200	56	4	31859b8db7ea17e48b7b54e92f0d76aeb755e7ca
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD8+_Tem\|URO / Disease, condition lineage and cell class	TTC16 RBL2 PARP8 SYTL2	1.16e-04	200	56	4	e621b46084839700e6dd338fdafc682a07cd698d
ToppCell	Sepsis-URO-Lymphocyte-T/NK\|URO / Disease, condition lineage and cell class	TTC16 PARP8 SYTL2 TXK	1.16e-04	200	56	4	ef40ed94261bdb79b7bde4196ff08bf327717b6b
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-MAIT\|Int-URO / Disease, condition lineage and cell class	TTC16 PARP8 SYTL2 DNM3	1.16e-04	200	56	4	043c18e79a969e37bbff86443e553ac09fe33f84
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	TTC16 RBL2 PARP8 SYTL2	1.16e-04	200	56	4	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB SHCBP1 DNM3	2.96e-04	103	56	3	3f4e4600c8a9af3534479ca19905c3d31c4c55bb
ToppCell	facs-Aorta-Heart-24m-Myeloid-professional_antigen_presenting_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 SPTB SHCBP1	4.40e-04	118	56	3	171afacd54b2e447f9f8c4511e93ff4504cd47cc
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Cdc20)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SHCBP1 CENPI SLCO1B3	5.97e-04	131	56	3	f9fb8d74ca720b81fd5910cc975510359a8ef751
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_2\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TTC16 APC RYR3	6.95e-04	138	56	3	05de2cef97c0912fb23f138dd45348f565a14d74
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	PARP8 APC ZNF292	6.95e-04	138	56	3	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCP10L DSP CEP126	6.95e-04	138	56	3	76be06136c83c167cedece7515228ed4d29dd1f0
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBM44 CTDSPL2 SYTL2	7.10e-04	139	56	3	7c02caed5b9baf233bd6fb9a453708b3e157c790
ToppCell	facs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG TTC16 ITPRID1	7.24e-04	140	56	3	115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCell	facs-Thymus-nan-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG TTC16 ITPRID1	7.24e-04	140	56	3	22d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCell	facs-Thymus-nan-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRTG TTC16 ITPRID1	7.24e-04	140	56	3	62d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TTC16 SPTB CEP126	7.55e-04	142	56	3	4ac3b285adfe80c47861943cf8c6188106cb3ba8
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TTC16 SPTB CEP126	8.68e-04	149	56	3	3e05711ad4a8c2e6ebe6f36b1cef8b17ec2a1708
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZSCAN4 SMARCAL1 SPTB	8.85e-04	150	56	3	c2c51a3230c978e2fdb1b3ae14193d4014431b25
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPTB SYTL2 RYR3	9.02e-04	151	56	3	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	Children_(3_yrs)-Immune-mast_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPTB SYTL2 RYR3	9.37e-04	153	56	3	d3fb83ca984c7583b1e51c364be6c7c17f67b048
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 SYTL2 TXK	9.54e-04	154	56	3	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	facs-BAT-Fat-24m-Lymphocytic-NK_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYTL2 CREBL2 TXK	9.72e-04	155	56	3	550e7e7e52829244ead829e5be010bfdc71e2ba5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZSCAN4 DNM3 RYR3	9.91e-04	156	56	3	f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZSCAN4 PARP8 APC	9.91e-04	156	56	3	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRTG SHCBP1 SYTL2	1.01e-03	157	56	3	0a552abfd139afc8516c38ca568f9922511dddce
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB SHCBP1 DNM3	1.01e-03	157	56	3	370f44047ef438b8f1124c2c2761c150c0d8c57f
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	JUP DSP SPTB	1.03e-03	158	56	3	3bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|368C / Donor, Lineage, Cell class and subclass (all cells)	TTC16 RBL2 RASGRP2	1.03e-03	158	56	3	390b9c455ed15a6804613eecfd2776949dfba146
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 SYTL2 TXK	1.03e-03	158	56	3	9f0987eaf1766aadb5714b68df7a5d310ea5a57a
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO1B3 SLC25A47 RASGRP2	1.03e-03	158	56	3	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC75B RYR3 TXK	1.05e-03	159	56	3	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 SYTL2 TXK	1.05e-03	159	56	3	94bc6ab248a8f02ccbc0facd24e0c7e9fda687d2
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC75B RYR3 TXK	1.05e-03	159	56	3	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP SLCO1B3 SLC25A47	1.07e-03	160	56	3	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYTL2 SLC25A47 TXK	1.07e-03	160	56	3	6b0faaa371650563f585722f5b2fb319e124ec38
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP7 ETAA1 TXK	1.08e-03	161	56	3	8e787cc7f5e818cad1a6ed143a5fe310993e030b
Computational	Genes in the cancer module 180.	BMP7 JUP DSP SYTL2 NSUN7	4.38e-05	119	36	5	MODULE_180
Drug	nNOS inhibitor I	JUP DSP RBL2 APC	7.52e-06	51	56	4	CID000656911
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A	CUL4B APC DNM3 SEPTIN11 FOXN3 PCM1	8.56e-06	196	56	6	2473_DN
Drug	Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	BMP7 DYNC2H1 RBL2 SEPTIN11 QSER1 NFAT5	8.81e-06	197	56	6	2860_DN
Drug	Rolipram [61413-54-5]; Down 200; 14.6uM; HL60; HT_HG-U133A	BMP7 APC DNM3 FOXN3 QSER1 RASGRP2	9.07e-06	198	56	6	3072_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	ZZZ3 SMARCAL1 NBN NR1H2 CNOT2	8.05e-05	180	56	5	1793_DN
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A	SMG7 RBL2 CENPI SEPTIN11 NFAT5	8.70e-05	183	56	5	1709_DN
Drug	AC1L1GT5	JUP DSP APC ADGRL2	8.85e-05	95	56	4	CID000003829
Drug	cesium carbonate	APC NBN	8.86e-05	6	56	2	CID000010796
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	DSP DYNC2H1 SPTB APC ADGRL2	9.16e-05	185	56	5	2949_UP
Drug	Ganciclovir [82410-32-0]; Down 200; 15.6uM; MCF7; HT_HG-U133A	CUL4B APC SEPTIN11 NFAT5 PCM1	9.64e-05	187	56	5	3368_DN
Drug	2-propylpentanoic acid; Up 200; 500uM; HL60; HT_HG-U133A	DSP DYNC2H1 SYTL2 SEPTIN11 ADGRL2	1.04e-04	190	56	5	6199_UP
Drug	Digitoxigenin [143-62-4]; Down 200; 10.6uM; PC3; HT_HG-U133A	RBL2 SMARCAL1 SEPTIN11 NBN GOLGA5	1.06e-04	191	56	5	4217_DN
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A	SMG7 APC NFAT5 PCM1 ZNF292	1.12e-04	193	56	5	2833_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	BMP7 PHF20L1 SYTL2 APC SEPTIN11	1.15e-04	194	56	5	3606_DN
Drug	Equilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A	CENPI APC DNM3 FOXN3 NFAT5	1.15e-04	194	56	5	3377_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT_HG-U133A	SMG7 DNM3 FOXN3 NFAT5 PCM1	1.15e-04	194	56	5	4319_DN
Drug	17-AAG; Up 200; 1uM; PC3; HG-U133A	BMP7 RBL2 SHCBP1 NFAT5 CNOT2	1.17e-04	195	56	5	450_UP
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	SMG7 RBL2 SMARCAL1 SYTL2 FOXN3	1.17e-04	195	56	5	6973_DN
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SMG7 DYNC2H1 SYTL2 APC NFAT5	1.17e-04	195	56	5	7035_DN
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HG-U133A	SMARCAL1 SHCBP1 CENPI NBN PCM1	1.17e-04	195	56	5	1934_DN
Drug	Amodiaquin dihydrochloride dihydrate [6398-98-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A	BMP7 ETAA1 FOXN3 PCM1 ZNF292	1.17e-04	195	56	5	6224_UP
Drug	Loracarbef [121961-22-6]; Down 200; 10.8uM; PC3; HT_HG-U133A	SMG7 ETAA1 APC FOXN3 PCM1	1.20e-04	196	56	5	5073_DN
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	CUL4B DYNC2H1 CENPI NFAT5 PCM1	1.20e-04	196	56	5	3268_DN
Drug	Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	BMP7 DYNC2H1 ETAA1 FOXN3 ZNF292	1.23e-04	197	56	5	5340_DN
Drug	Droperidol [548-73-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	BMP7 PARP8 FOXN3 RASGRP2 TXK	1.23e-04	197	56	5	4629_UP
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	SPTB CDYL QSER1 NFAT5 PCM1	1.23e-04	197	56	5	1641_UP
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A_EA	SMG7 SYTL2 FOXN3 NFAT5 PCM1	1.26e-04	198	56	5	1073_DN
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; MCF7; HT_HG-U133A	BMP7 SMG7 RBL2 SYTL2 PCM1	1.26e-04	198	56	5	5358_DN
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; MCF7; HT_HG-U133A	SMG7 SYTL2 APC NBN CREBL2	1.26e-04	198	56	5	5515_DN
Drug	Demecarium bromide [56-94-0]; Down 200; 5.6uM; MCF7; HT_HG-U133A	SMG7 DYNC2H1 SYTL2 ETAA1 PCM1	1.26e-04	198	56	5	6269_DN
Drug	Amiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; HL60; HG-U133A	SMG7 RBL2 SMARCAL1 FOXN3 NFAT5	1.26e-04	198	56	5	1970_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	DYNC2H1 SPTB FOXN3 QSER1 PCM1	1.29e-04	199	56	5	4316_DN
Drug	Methoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; PC3; HT_HG-U133A	RBL2 SEPTIN11 NR1H2 PCM1 ZNF292	1.29e-04	199	56	5	6355_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CUL4B SMG7 ETAA1 NFAT5 PCM1	1.29e-04	199	56	5	4687_DN
Drug	Naproxen [22204-53-1]; Up 200; 17.4uM; HL60; HT_HG-U133A	BMP7 JUP NR1H2 FOXN3 PCM1	1.32e-04	200	56	5	1869_UP
Drug	nordihydroguaiaretic acid; Up 200; 1uM; HL60; HT_HG-U133A	SPTB SYTL2 DNM3 SEPTIN11 RASGRP2	1.32e-04	200	56	5	1164_UP
Disease	Epidermolysis bullosa, lethal acantholytic	JUP DSP	3.05e-06	2	52	2	C1864826
Disease	selenium measurement	DYNC2H1 FOXN3 ADGRL2	1.83e-05	29	52	3	EFO_0006331
Disease	prostate cancer (is_implicated_in)	BMP7 JUP APC NBN	5.49e-05	117	52	4	DOID:10283 (is_implicated_in)
Disease	Arrhythmogenic right ventricular cardiomyopathy	JUP DSP	6.36e-05	7	52	2	cv:C0349788
Disease	Sudden Cardiac Arrest	KCND2 DSP	8.47e-05	8	52	2	C1720824
Disease	Colorectal Carcinoma	ZZZ3 PARP8 ETAA1 APC SLCO1B3 ITPRID1 ZNF292	2.21e-04	702	52	7	C0009402
Disease	diet measurement, HOMA-B	NFAT5 CREBL2	5.11e-04	19	52	2	EFO_0004469, EFO_0008111
Disease	gastric ulcer	JUP ZNF800	6.26e-04	21	52	2	EFO_0009454
Disease	endometrial cancer (is_marker_for)	JUP APC	1.75e-03	35	52	2	DOID:1380 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAQEKNTGTNRTQKQ	TDRD5	816	Q8NAT2
RKASQQSNQIQTQRT	CTDSPL2	6	Q05D32
SIQLSANTVKQNSRN	ADGRL2	696	O95490
SKQRSQNRSKTPKNQ	BMP7	296	P18075
GNRISSNNLEKSTNK	RBM44	916	Q6ZP01
STQVSNGGLQQKTSQ	QSER1	241	Q2KHR3
NSTTSQKQSKQRKRG	H2BW1	51	Q7Z2G1
QQKQGQSVTSSSNRP	RBL2	816	Q08999
NTSQSQKKGQQSQFL	PARP8	766	Q8N3A8
QQSRKDNSNSLQVKT	RASGRP2	61	Q7LDG7
SVKGRTQKENLFQTN	ITPRID1	356	Q6ZRS4
RNQLTNKTLSNSSQS	GOLGA5	571	Q8TBA6
QNGTAITFINNNSKR	DDX59	541	Q5T1V6
QRSSQVHKKTTVGNQ	DNM3	501	Q9UQ16
TKQNSNNTRGNANKT	PCM1	706	Q15154
QSKRNGLLSNQLQSS	KCND2	446	Q9NZV8
KQQQGSSLRQRKTQS	LRRC75B	126	Q2VPJ9
NRGVSEKQLTSNTVQ	NFAT5	116	O94916
NNSKNKTLVTQNSGV	JUP	421	P14923
KGNTKISVANNQNSS	ETAA1	256	Q9NY74
RKSSASKTAQNGTQQ	PRTG	976	Q2VWP7
RQLNKSGTTQNANES	DYNC2H1	1881	Q8NCM8
SGLQKRSTSVNLNQA	HEATR5B	1556	Q9P2D3
NNARKQISRSTNSNF	CDYL	131	Q9Y232
STSNIRSGKNIQVSQ	CEP126	806	Q9P2H0
NNITNRTAKGQKEQK	FOXN3	471	O00409
QQQKATGSEVSQRKQ	DSP	1431	P15924
EQNKSQQNSSRHTKA	CREBL2	96	O60519
TAVQVKSFTKQGQQR	BCE1	6	O60756
RVKNVQAQNRTSQGS	CENPI	6	Q92674
SPTAATSQQQQLKNK	CUL4B	146	Q13620
ESTLSNKRKNNQGNS	PHF20L1	256	A8MW92
HSSQQTKNEQSKNGR	SYTL2	171	Q9HCH5
QSQAQQSGAQQTKKD	SEPTIN11	406	Q9NVA2
KNQSATLLGQRSSSN	TCP10L	146	Q8TDR4
KSKDRASQQQQTNSI	NBN	441	O60934
QKNTAQVGASSQTRK	NSUN7	591	Q8NE18
RKQQQESQSQSQSPV	NR1H2	171	P55055
KNQITTLQGQAKNRA	SMG7	66	Q92540
RLQQKSGSSVQKGVN	SMARCAL1	221	Q9NZC9
QTQAQKQQRRLSASG	SLC25A47	126	Q6Q0C1
NSNIQAKGVRSSGQK	SHCBP1	316	Q8NEM2
TSNQQSANKTQAIAK	APC	1901	P25054
KNVLVKQGSSSSQLQ	CIPC	96	Q9C0C6
KSSTTQNNNQQKKGI	CNOT2	321	Q9NZN8
FQGQSSSQAQQVIKR	ZBTB21	646	Q9ULJ3
NEKLRSVSQANQGNS	RYR3	2701	Q15413
NALQSQTRNNLTTSK	SPATA31D1	1151	Q6ZQQ2
NQTANLTNQGKNVTK	SLCO1B3	306	Q9NPD5
QCNTNALTNTQTKGR	ZNF292	2066	O60281
NSRKFANSLTGVQQQ	SPTB	326	P11277
KTTRVNENITNQGNQ	ZSCAN4	201	Q8NAM6
SQLSNKKQSNTGRVQ	TXK	51	P42681
TRKNPNQSSKGRSKN	ZNF800	266	Q2TB10
NSSKTKATQSQRRNS	TTC16	706	Q8NEE8
KGNNNGRTTDLKQQS	ZZZ3	61	Q8IYH5
QKTNQCLQGQSLKTS	USP54	1091	Q70EL1