Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	NDUF_C2	NDUFC2-KCTD14 NDUFC2	4.25e-06	2	39	2	PF06374
Domain	NADH-UbQ_OxRdtase_b14.5b_su	NDUFC2-KCTD14 NDUFC2	4.25e-06	2	39	2	IPR009423
Domain	Glutathione-S-Trfase_C-like	MTX1 VARS1	3.00e-03	39	39	2	IPR010987
Domain	-	MTX1 VARS1	3.00e-03	39	39	2	1.20.1050.10
Domain	PH_dom-like	JAK1 TRIOBP DGKD ARHGAP23	1.17e-02	426	39	4	IPR011993
Domain	RRM	ZNF638 TNRC6B RBFOX2	1.22e-02	230	39	3	PS50102
Pubmed	NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.	NDUFC2-KCTD14 NDUFC2	1.36e-06	2	41	2	37506315
Pubmed	De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.	PRKDC DNMT3A	4.06e-06	3	41	2	17420264
Pubmed	TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.	NDUFC2-KCTD14 NDUFC2	8.12e-06	4	41	2	38385898
Pubmed	Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.	JAK1 PNPLA2	8.12e-06	4	41	2	29692363
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	ZNF638 CHSY1 TNRC6B ANKRD17 RFC5 RBFOX2	1.61e-05	462	41	6	31138677
Pubmed	Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.	PNPLA2 PRKDC	2.84e-05	7	41	2	36476935
Pubmed	Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos.	NDUFC2-KCTD14 NDUFC2	3.78e-05	8	41	2	9425147
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	ZNF638 PRKDC RREB1 RFC5 VARS1	4.35e-05	332	41	5	32786267
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	ZNF638 PRKDC BBX RFC5 RBFOX2	4.87e-05	340	41	5	24332808
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	ARHGAP23 CDH10 DNMT3A	6.91e-05	67	41	3	29254152
Pubmed	UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.	ANTXR1 PRKDC	7.41e-05	11	41	2	11709713
Pubmed	Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.	PRKDC PPP2R5D	8.88e-05	12	41	2	16541024
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	JAK1 ANKRD17 RFC5 VARS1	1.14e-04	212	41	4	33853758
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ZNF638 TRIOBP JCAD CCDC8 PPP2R5D TULP3 CEP135	2.04e-04	1049	41	7	27880917
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	ZNF638 TRIOBP ANKRD17 LBP RFC5 RBFOX2	2.04e-04	732	41	6	34732716
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	TNRC6B PPP2R5D	2.05e-04	18	41	2	25363768
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZNF638 TNRC6B PPP2R5D RREB1 VARS1 CEP135	2.06e-04	733	41	6	34672954
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF638 TRIOBP TNRC6B PRKDC BBX VARS1 DNMT3A	2.47e-04	1082	41	7	38697112
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	TNRC6B ANKRD17 PRKDC	2.77e-04	107	41	3	30995489
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	TNRC6B VARS1	2.81e-04	21	41	2	33029523
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF638 TRIOBP TNRC6B ANKRD17 ANTXR1 DHRS3 RBFOX2 TULP3	2.99e-04	1489	41	8	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIOBP CHSY1 ANKRD17 EDEM1 SZT2	3.81e-04	529	41	5	14621295
Pubmed	PIDD orchestrates translesion DNA synthesis in response to UV irradiation.	PRKDC RFC5	4.00e-04	25	41	2	21415862
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	TNRC6B ANTXR1 PPP2R5D CEP135	4.38e-04	302	41	4	30561431
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	JCAD TNRC6B PPP2R5D RFC5 RBFOX2 CEP135	4.62e-04	853	41	6	28718761
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TNRC6B ARHGAP23 TULP3 LGALS8	4.66e-04	307	41	4	37499664
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	PRKDC VARS1	4.67e-04	27	41	2	36266428
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	PRKDC VARS1	5.03e-04	28	41	2	35227662
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	JAK1 CHSY1 ANKRD17 RFC5	5.51e-04	321	41	4	32098917
Pubmed	A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.	PRKDC RFC5	6.17e-04	31	41	2	12171929
Pubmed	TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.	PRKDC RFC5	6.17e-04	31	41	2	26095369
Pubmed	Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.	NDUFC2-KCTD14 NDUFC2	6.17e-04	31	41	2	36127325
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	JAK1 ZNF638 PPP2R5D RFC5	6.91e-04	341	41	4	32971831
Pubmed	Region-specific expression of mitochondrial complex I genes during murine brain development.	NDUFC2-KCTD14 NDUFC2	7.43e-04	34	41	2	21556144
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CHSY1 ANKRD17 PRKDC PPP2R5D MTX1 VARS1	7.78e-04	942	41	6	31073040
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	ZNF638 PDF CCDC8 PPP2R5D BBX RREB1 TULP3	8.14e-04	1321	41	7	27173435
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZNF638 TNRC6B BBX DNMT3A CEP135	9.32e-04	645	41	5	25281560
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF638 ANKRD17 DGKD PRKDC RFC5 ARHGAP23 VARS1	9.36e-04	1353	41	7	29467282
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ZNF638 ANKRD17 ANTXR1 EDEM1 ARHGAP23	9.65e-04	650	41	5	38777146
Pubmed	Proteomic analysis of the mouse liver mitochondrial inner membrane.	NDUFC2-KCTD14 MTX1 NDUFC2	1.16e-03	175	41	3	12865426
Cytoband	22q13.1	TRIOBP TNRC6B RBFOX2	6.21e-05	85	41	3	22q13.1
Cytoband	2p13.1	ZNF638 ANTXR1	4.29e-04	34	41	2	2p13.1
Cytoband	11q14.1	NDUFC2-KCTD14 NDUFC2	6.55e-04	42	41	2	11q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	KLHDC7B TRIOBP TNRC6B	3.21e-03	330	41	3	chr22q13
Coexpression	GSE28737_WT_VS_BCL6_KO_FOLLICULAR_BCELL_DN	JAK1 TNRC6B PRKDC DHRS3 LGALS8	1.47e-05	200	41	5	M9374
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFN1 CORO2B EDEM1 VARS1 MCOLN2	5.47e-07	174	41	5	c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFN1 CORO2B EDEM1 MCOLN2	1.91e-05	173	41	4	60e427f6c7d953cef5f692043670ff0b49cdce72
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 JCAD CORO2B ARHGAP23	2.33e-05	182	41	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2B EDEM1 VARS1 MCOLN2	2.44e-05	184	41	4	82d2daa39e3c31a74c08a5d77366740b87beb2fb
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK1 ANKRD17 DGKD DNMT3A	2.49e-05	185	41	4	a2cae8c657e4f4d121476798e424876f7e247973
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK1 ANKRD17 DGKD DNMT3A	2.49e-05	185	41	4	d50406a9a5b8d75110ba5985741aa2293950c543
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	ANKRD17 DHRS3 VARS1 MCOLN2	3.12e-05	196	41	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
Disease	hematocrit	JCAD TNRC6B ANKRD17 DGKD RREB1 DHRS3 MTX1 DNMT3A	5.36e-05	1011	40	8	EFO_0004348
Disease	T-cell acute lymphoblastic leukemia (is_implicated_in)	JAK1 DNMT3A	9.78e-05	11	40	2	DOID:5603 (is_implicated_in)
Disease	uridine diphosphate galactose measurement, uridine diphosphate glucose measurement	JCAD IGFN1	2.41e-04	17	40	2	EFO_0010543, EFO_0010544
Disease	monocyte count	KLHDC7B JCAD PRKDC BBX RREB1 ARHGAP23 SZT2 VARS1	3.36e-04	1320	40	8	EFO_0005091
Disease	basophil count	TRIOBP CHSY1 PRKDC LBP RREB1	4.72e-04	483	40	5	EFO_0005090
Disease	mean corpuscular hemoglobin concentration	ZNF638 TNRC6B ANTXR1 PRKDC RREB1 KIAA2012 TULP3	6.40e-04	1105	40	7	EFO_0004528
Disease	lymphocyte count	JAK1 ZNF638 JCAD TNRC6B DGKD RREB1 VARS1 DNMT3A	6.69e-04	1464	40	8	EFO_0004587
Disease	Sclerocystic Ovaries	TNRC6B PNPLA2 ARHGAP23	9.85e-04	144	40	3	C1136382
Disease	Polycystic Ovary Syndrome	TNRC6B PNPLA2 ARHGAP23	9.85e-04	144	40	3	C0032460
Disease	red blood cell density measurement	TNRC6B ANTXR1 RREB1 DHRS3 MTX1 DNMT3A	1.12e-03	880	40	6	EFO_0007978
Disease	calcium measurement	DGKD BBX RREB1 MTX1 DNMT3A	1.53e-03	628	40	5	EFO_0004838
Disease	myeloid white cell count	CHSY1 JCAD BBX RREB1 ARHGAP23 DNMT3A	1.54e-03	937	40	6	EFO_0007988
Disease	platelet crit	JAK1 JCAD DGKD BBX RREB1 LGALS8	1.67e-03	952	40	6	EFO_0007985
Disease	open-angle glaucoma	TRIOBP ANTXR1 DGKD	2.21e-03	191	40	3	EFO_0004190
Disease	chronic obstructive pulmonary disease	JCAD ANTXR1 RREB1 VARS1 DNMT3A	2.28e-03	688	40	5	EFO_0000341
Disease	neutrophil count	CHSY1 JCAD PRKDC BBX RREB1 ARHGAP23 TULP3	2.34e-03	1382	40	7	EFO_0004833
Disease	optic cup area measurement	TRIOBP DHRS3	2.63e-03	56	40	2	EFO_0006940
Disease	cup-to-disc ratio measurement	TRIOBP CHSY1 RREB1 DHRS3	2.69e-03	430	40	4	EFO_0006939
Disease	migraine disorder, type 2 diabetes mellitus	RREB1 KIAA2012	3.02e-03	60	40	2	MONDO_0005148, MONDO_0005277
Disease	obesity (implicated_via_orthology)	PNPLA2 LBP TULP3	3.09e-03	215	40	3	DOID:9970 (implicated_via_orthology)
Disease	total blood protein measurement	ZNF638 DGKD BBX RREB1	3.14e-03	449	40	4	EFO_0004536
Disease	cutaneous melanoma, hair color	RREB1 DNMT3A	3.22e-03	62	40	2	EFO_0000389, EFO_0003924
Disease	hearing loss	KLHDC7B TRIOBP	3.75e-03	67	40	2	EFO_0004238

Protein segments in the cluster

Peptide	Gene	Start	Entry
RENFPNVLQPLPRMF	nan	86	A8MZ25
EFPEPRNLNNNMRRP	ANTXR1	426	Q9H6X2
PEQRARRPMNAFLLF	BBX	76	Q8WY36
RQRPMPRLTFQAGDP	DNMT3A	181	Q9Y6K1
RPNPFRRQSIVLDPM	C16orf78	146	Q8WTQ4
ELARLNPQYPMFRAP	PPP2R5D	511	Q14738
AAQTFQQIRPPRLPM	ANKRD17	1896	O75179
SNIPFRFRDPDLRQM	RBFOX2	126	O43251
DPNQRPFFRAIMRDI	JAK1	831	P23458
NVAFPPEALRMRAPA	PNPLA2	451	Q96AD5
FRPFVPRLARLYPNM	LBP	321	P18428
PQLRLPFAARLNTPM	LGALS8	181	O00214
FRGNSPEMRVEPQPR	JCAD	881	Q9P266
RRDFMRNFINPPVPL	JRK	336	O75564
MIARRNPEPLRFLPD	NDUFC2	1	O95298
LPNMRVPRRALPAAQ	KIAA2012	571	Q0VF49
PPRQRALRQMEPFPL	PDF	136	Q9HBH1
FRRQRMQIDEPVPPS	CEP135	166	Q66GS9
LEMLRRPTFRNPFNE	IGSF10	2331	Q6WRI0
PPRTENELLRMFFRQ	CORO2B	431	Q9UQ03
SPEIMFRRTPVPQQR	CDH10	21	Q9Y6N8
AFPPQLRAQMRDLAR	EDEM1	121	Q92611
CPARPQIFRPREQLM	DGKD	596	Q16760
MVLRSHPFPRQDRPQ	KLHDC7B	1	Q96G42
VFARDPMRPPGLVRN	IGFN1	836	Q86VF2
APPARRRVNLPVPMF	CCDC8	166	Q9H0W5
MARQPYRFPQARIPE	MCOLN2	1	Q8IZK6
MFQGMRVRFPNLFPP	DHRS3	226	O75911
PFPLNFFLPGRMQRQ	MTX1	281	Q13505
LFQRLPRRMPQAPPS	VARS1	1071	P26640
MQPPQAPRDLIFRTQ	SZT2	1256	Q5T011
RFRFGPLTPELMVPR	RFC5	171	P40937
RRPYRVMDLNPAPNQ	ODF3L1	146	Q8IXM7
RMPGDRPTLFNPFLL	TRIOBP	1751	Q9H2D6
LGIPPSFMRFQPRQR	CHSY1	356	Q86X52
QPLFYPQPLVNMRRF	ZNF826P	46	Q6ZT77
LPRDAMGRPFIQNNP	RREB1	261	Q92766
LPNRIPSLRMLRSFF	ARHGAP23	641	Q9P227
MIARRNPEPLRFLPD	NDUFC2-KCTD14	1	E9PQ53
QFLPVPELMPFRLTR	PRKDC	3951	P78527
PELMPFRLTRQFINL	PRKDC	3956	P78527
PFMVQPNPEARLRRA	TULP3	46	O75386
MSRPRFNPRGDFPLQ	ZNF638	1	Q14966
YMPREVPPRFRCQQD	TNRC6B	86	Q9UPQ9