Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

1.68e-054342GO:0047696
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

5.88e-057342GO:0004703
GeneOntologyMolecularFunctionhistone methyltransferase binding

PAXBP1 ZNF335

4.23e-0418342GO:1990226
GeneOntologyMolecularFunctionphosphatidylinositol phospholipase C activity

PLCB3 PLCB4

8.91e-0426342GO:0004435
GeneOntologyMolecularFunctionphospholipase C activity

PLCB3 PLCB4

1.11e-0329342GO:0004629
HumanPhenoAbnormality of cartilage of external ear

PLCB4 SLC16A2 ABCC6

7.99e-0618123HP:3000022
HumanPhenoAbnormality of cartilage morphology

PLCB4 SLC16A2 ABCC6

1.72e-0523123HP:0410007
HumanPhenoAbnormality of the thyroid gland

UBR1 MRPS7 PLAGL1 ZFAT SLC16A2 ABCC6 CASZ1

7.84e-05548127HP:0000820
HumanPhenoAbnormal cartilage morphology

PLCB4 SLC16A2 ABCC6

1.73e-0449123HP:0002763
HumanPhenoAbnormality of thyroid physiology

UBR1 MRPS7 PLAGL1 SLC16A2 ABCC6 CASZ1

1.95e-04425126HP:0002926
Domainzf-C2H2

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

2.19e-06693339PF00096
DomainZINC_FINGER_C2H2_2

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

5.47e-06775339PS50157
DomainZINC_FINGER_C2H2_1

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

5.59e-06777339PS00028
DomainZnf_C2H2-like

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

6.80e-06796339IPR015880
DomainZnf_C2H2

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

7.45e-06805339IPR007087
DomainZnF_C2H2

TRERF1 PLAGL1 ZFAT ZIK1 ZNF280D CASZ1 ZNF335 ZXDB ZNF197

7.67e-06808339SM00355
DomainPLC-beta_CS

PLCB3 PLCB4

9.07e-063332IPR009535
DomainDUF1154

PLCB3 PLCB4

9.07e-063332PF06631
DomainPLC-beta

PLCB3 PLCB4

1.81e-054332IPR016280
Domain-

PLCB3 PLCB4 GRK2 GRK3 ASAP1 FGD3

5.56e-053913362.30.29.30
DomainGPCR_kinase

GRK2 GRK3

6.32e-057332IPR000239
DomainPH_dom-like

PLCB3 PLCB4 GRK2 GRK3 ASAP1 FGD3

8.93e-05426336IPR011993
Domain-

TRERF1 PLAGL1 ZFAT ZIK1 ZNF335 ZXDB ZNF197

1.52e-046793373.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

TRERF1 PLAGL1 ZFAT ZIK1 ZNF335 ZXDB ZNF197

1.74e-04694337IPR013087
DomainPIPLC_Y_DOMAIN

PLCB3 PLCB4

3.13e-0415332PS50008
DomainPI-PLC_fam

PLCB3 PLCB4

3.13e-0415332IPR001192
DomainPLC_EF-hand-like

PLCB3 PLCB4

3.13e-0415332IPR015359
DomainPI-PLC-Y

PLCB3 PLCB4

3.13e-0415332PF00387
DomainPLipase_C_Pinositol-sp_Y

PLCB3 PLCB4

3.13e-0415332IPR001711
DomainEF-hand_like

PLCB3 PLCB4

3.13e-0415332PF09279
DomainPLCYc

PLCB3 PLCB4

3.13e-0415332SM00149
DomainPI-PLC-X

PLCB3 PLCB4

4.55e-0418332PF00388
DomainPLCXc

PLCB3 PLCB4

4.55e-0418332SM00148
DomainPIPLC_X_DOMAIN

PLCB3 PLCB4

5.08e-0419332PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB3 PLCB4

5.08e-0419332IPR000909
DomainPH

GRK2 GRK3 ASAP1 FGD3

6.81e-04229334PF00169
Domain-

PLCB3 PLCB4

8.85e-04253323.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCB3 PLCB4

8.85e-0425332IPR017946
DomainPH

GRK2 GRK3 ASAP1 FGD3

1.40e-03278334SM00233
DomainPH_DOMAIN

GRK2 GRK3 ASAP1 FGD3

1.42e-03279334PS50003
DomainPH_domain

GRK2 GRK3 ASAP1 FGD3

1.44e-03280334IPR001849
DomainRGS

GRK2 GRK3

1.74e-0335332PF00615
DomainRGS

GRK2 GRK3

1.74e-0335332SM00315
DomainRGS

GRK2 GRK3

1.84e-0336332PS50132
DomainAAA+_ATPase

ATAD2 DNAH6 ABCC6

2.07e-03144333IPR003593
DomainAAA

ATAD2 DNAH6 ABCC6

2.07e-03144333SM00382
DomainRGS

GRK2 GRK3

2.15e-0339332IPR016137
DomainSer/Thr_kinase_AS

GRK2 GRK3 CSNK1G3 MAP3K19

3.47e-03357334IPR008271
DomainS_TKc

GRK2 GRK3 CSNK1G3 MAP3K19

3.54e-03359334SM00220
DomainPROTEIN_KINASE_ST

GRK2 GRK3 CSNK1G3 MAP3K19

3.64e-03362334PS00108
DomainProtein_kinase_ATP_BS

GRK2 GRK3 CSNK1G3 MAP3K19

4.29e-03379334IPR017441
DomainPkinase

GRK2 GRK3 CSNK1G3 MAP3K19

4.37e-03381334PF00069
DomainAGC-kinase_C

GRK2 GRK3

4.39e-0356332IPR000961
DomainAGC_KINASE_CTER

GRK2 GRK3

4.39e-0356332PS51285
DomainS_TK_X

GRK2 GRK3

4.39e-0356332SM00133
DomainPROTEIN_KINASE_ATP

GRK2 GRK3 CSNK1G3 MAP3K19

8.38e-03459334PS00107
Domain-

SEPTIN7 ATAD2 DNAH6 ABCC6 BMS1

9.41e-037463353.40.50.300
DomainProt_kinase_dom

GRK2 GRK3 CSNK1G3 MAP3K19

1.04e-02489334IPR000719
DomainPROTEIN_KINASE_DOM

GRK2 GRK3 CSNK1G3 MAP3K19

1.07e-02493334PS50011
DomainKinase-like_dom

GRK2 GRK3 CSNK1G3 MAP3K19

1.47e-02542334IPR011009
DomainP-loop_NTPase

SEPTIN7 ATAD2 DNAH6 ABCC6 BMS1

1.57e-02848335IPR027417
DomainC2

PLCB3 PLCB4

2.24e-02131332PF00168
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PLCB3 PLCB4 GRK2

4.87e-0539263MM14496
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB3 PLCB4

4.88e-056262M47548
PathwayWP_HEDGEHOG_SIGNALING_WP4249

GRK2 GRK3 CSNK1G3

6.55e-0543263M39706
PathwayKEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY

PLCB3 PLCB4

6.83e-057262M47505
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PLCB3 PLCB4 GRK2

1.30e-0454263M26911
PathwayKEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

1.46e-0410262M47644
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB3 PLCB4

1.46e-0410262M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB3 PLCB4

1.78e-0411262M49033
PathwayKEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

1.78e-0411262M47637
PathwayKEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

2.13e-0412262M47649
PathwayKEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY

PLCB3 PLCB4

2.13e-0412262M47628
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB3 PLCB4

2.52e-0413262M47656
PathwayREACTOME_OPIOID_SIGNALLING

PLCB3 PLCB4 GRK2

2.93e-0471263MM14491
PathwayKEGG_CHEMOKINE_SIGNALING_PATHWAY

PLCB3 PLCB4 GRK2 GRK3

3.64e-04188264M4844
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

4.91e-0418262M47659
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB3 PLCB4

5.49e-0419262M47543
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

PLCB3 PLCB4

5.49e-0419262M47596
PathwayREACTOME_OPIOID_SIGNALLING

PLCB3 PLCB4 GRK2

5.88e-0490263M6467
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

6.09e-0420262M47688
PathwayKEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

6.72e-0421262M47638
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB3 PLCB4

6.72e-0421262M47542
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

6.72e-0421262M47689
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

PLCB3 PLCB4

7.39e-0422262M39795
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

7.39e-0422262M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

7.39e-0422262M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB3 PLCB4

8.08e-0423262M47676
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB3 PLCB4

1.03e-0326262M27053
PathwayKEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

1.03e-0326262M47557
PathwayPID_IL8_CXCR1_PATHWAY

PLCB3 GRK2

1.20e-0328262M252
PathwayKEGG_MEDICUS_REFERENCE_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

PLCB3 PLCB4

1.20e-0328262M47508
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB3 PLCB4

1.20e-0328262MM14711
PathwayWP_GPR143_IN_MELANOCYTES_AND_RETINAL_PIGMENT_EPITHELIUM_CELLS

PLCB3 PLCB4

1.38e-0330262M42578
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY

PLCB3 PLCB4

1.47e-0331262M47554
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

PLCB3 PLCB4

1.67e-0333262M39745
PathwayWP_KISSPEPTINKISSPEPTIN_RECEPTOR_SYSTEM_IN_THE_OVARY

PLCB3 PLCB4

2.32e-0339262M39905
PathwayPID_THROMBIN_PAR1_PATHWAY

PLCB3 GRK3

2.82e-0343262M238
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PLCB3 PLCB4

3.22e-0346262M48317
PathwayWP_CHEMOKINE_SIGNALING

PLCB3 PLCB4 GRK2

3.36e-03165263M39400
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCB3 PLCB4

3.50e-0348262MM14589
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCB3 PLCB4

3.50e-0348262M26964
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PLCB3 PLCB4

3.65e-0349262M40046
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

PLCB3 PLCB4

3.79e-0350262M47951
PathwayKEGG_ENDOCYTOSIS

GRK2 GRK3 ASAP1

4.36e-03181263M1519
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PLCB3 PLCB4

4.41e-0354262M3896
PathwayWP_CHEMOKINE_SIGNALING_PATHWAY

PLCB3 PLCB4 GRK2

4.56e-03184263MM15943
PathwayPID_TXA2PATHWAY

GRK2 GRK3

4.74e-0356262M99
PathwayREACTOME_RRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL

RRP7A BMS1

5.42e-0360262M27613
PathwayREACTOME_SIGNALING_BY_GPCR

PLCB3 PLCB4 GRK2 GRK3 FGD3

5.87e-03646265MM14962
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PLCB3 PLCB4 GRK2

6.58e-03210263MM15043
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PLCB3 PLCB4 GRK2

7.20e-03217263M18437
PathwayKEGG_LONG_TERM_POTENTIATION

PLCB3 PLCB4

7.31e-0370262M3115
PathwayKEGG_LONG_TERM_DEPRESSION

PLCB3 PLCB4

7.31e-0370262M8232
PathwayWP_ALZHEIMERS_DISEASE

PLCB3 PLCB4

8.14e-0374262MM15962
PathwayREACTOME_SIGNALING_BY_GPCR

PLCB3 PLCB4 GRK2 GRK3 FGD3

8.30e-03702265M746
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

PLCB3 PLCB4

8.36e-0375262M39568
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PLCB3 PLCB4

8.57e-0376262M9052
Pubmed

Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

PLCB4 GRK2 GRK3

7.81e-08935334873237
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

9.84e-07235211762794
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

9.84e-0723528035170
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

9.84e-0723528638670
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

9.84e-07235210198406
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

9.84e-07235233060647
Pubmed

Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum.

PLCB3 PLCB4

9.84e-07235216566000
Pubmed

Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons.

PLCB3 PLCB4

9.84e-07235217114052
Pubmed

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

GRK2 GRK3

2.95e-06335210754297
Pubmed

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

GRK2 GRK3

2.95e-06335210085131
Pubmed

Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

GRK2 GRK3

2.95e-06335212130708
Pubmed

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

GRK2 GRK3

2.95e-0633527761854
Pubmed

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.

GRK2 GRK3

2.95e-06335231604529
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK2 GRK3

5.90e-0643528662816
Pubmed

Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.

PLCB3 PLCB4

5.90e-06435231268747
Pubmed

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

PLCB3 PLCB4

5.90e-06435223006664
Pubmed

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PLCB3 PLCB4

5.90e-0643529753089
Pubmed

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

GRK2 GRK3

5.90e-06435223734232
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK2 GRK3

5.90e-0643528917529
Pubmed

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.

PLCB3 PLCB4

5.90e-0643529305844
Pubmed

Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.

PLCB3 PLCB4

5.90e-06435215174099
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK2 GRK3

5.90e-06435221784156
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK2 GRK3

9.82e-06535210338466
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 UBR1 PPIG PLCB3 PAXBP1 ATAD2 ZNF335

1.03e-0577435715302935
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK2 GRK3

1.47e-05635236451830
Pubmed

Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.

PLCB3 PLCB4

1.47e-0563528739298
Pubmed

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

PLCB3 PLCB4

1.47e-0563522841328
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK2 GRK3

1.47e-0563529826657
Pubmed

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.

GRK2 GRK3

1.47e-05635220074556
Pubmed

Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.

PLCB3 PLCB4

2.06e-05735210609087
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK2 GRK3

2.06e-0573528672451
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK2 GRK3

2.06e-05735211517230
Pubmed

Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.

PLCB3 PLCB4

3.53e-0593527589147
Pubmed

Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.

PLCB3 PLCB4

3.53e-05935210501179
Pubmed

Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism.

PLCB3 PLCB4

4.40e-051035223295235
Pubmed

Expression of phospholipase C isozymes by murine B lymphocytes.

PLCB3 PLCB4

4.40e-05103522033248
Pubmed

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

GRK2 GRK3

4.40e-05103521869533
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

PLCB3 PLCB4

1.02e-041535228578927
Pubmed

A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.

UBR1 FMN1

1.17e-04163527633422
Pubmed

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

PLCB3 PLCB4

1.49e-04183521979339
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 CCNT1 PAXBP1 CASZ1

1.50e-0426835433640491
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

AKAP11 GRK3 SEPTIN7 ASAP1

1.79e-0428135428706196
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

PLCB3 PLCB4

2.04e-042135230270038
Pubmed

The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.

PLCB3 PLCB4

2.46e-04233529278385
Pubmed

HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.

PLCB3 PLCB4

2.46e-04233529730685
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCB3 PLCB4

2.68e-042435210843712
Pubmed

Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.

PLAGL1 ASAP1

3.15e-042635215890332
Pubmed

Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.

PLCB3 PLCB4

3.40e-042735220336759
Pubmed

Genetic mapping of the human and mouse phospholipase C genes.

PLCB3 PLCB4

5.09e-04333528672127
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CCNT1 MRPS7 RRP7A PAXBP1 ATAD2 CASZ1 BMS1

6.29e-04149735731527615
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PLCB3 PLCB4

6.76e-043835212482669
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

CCNT1 MRPS7 PPIG PAXBP1 BMS1

6.96e-0471335529802200
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

CCNT1 AKAP11 GRK2 GRK3

9.06e-0443235423455922
CytobandEnsembl 112 genes in cytogenetic band chr8q24

ZFAT ATAD2 ASAP1

2.50e-03355353chr8q24
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

PLAGL1 ZFAT ZIK1 CASZ1 ZNF335 ZXDB ZNF197

5.14e-0571826728
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

GRK2 GRK3 ASAP1 FGD3

2.01e-04206264682
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCB3 PLCB4

3.35e-0419262832
GeneFamilyPhospholipases

PLCB3 PLCB4

1.65e-0342262467
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLAGL1 DNAH6 FMN1 OLR1

1.05e-051803448923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 FMN1 OLR1 CASZ1

1.09e-051823445f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

PLCB4 FMN1 OLR1 CASZ1

1.24e-05188344df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1 FGD3

1.49e-05197344e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLAGL1 DNAH6 FMN1 OLR1

1.58e-052003447cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCellNeuronal-Excitatory-eG(DAPK2)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLAGL1 DNAH6 FMN1 OLR1

1.58e-05200344193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCellNeuronal-Excitatory-eG(DAPK2)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLAGL1 DNAH6 FMN1 OLR1

1.58e-052003447c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCellNeuronal-Excitatory-eG(DAPK2)----L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLAGL1 DNAH6 FMN1 OLR1

1.58e-05200344d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCellNeuronal-Excitatory-eG(DAPK2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLAGL1 DNAH6 FMN1 OLR1

1.58e-052003448444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFAT ATAD2 OLR1

1.64e-04140343e442c46979d725ec82f525a001c46d971fcade4d
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GRK2 SLC16A2 OLR1

1.75e-041433434622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GRK2 SLC16A2 OLR1

1.75e-041433439836a040a2ebcf6f05431e658a7b8fd566621452
ToppCell390C-Lymphocytic-NK_cells-NK_cell_E|390C / Donor, Lineage, Cell class and subclass (all cells)

ZIK1 ATAD2 FGD3

2.22e-0415534398d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UBR1 ZFAT FGD3

2.30e-04157343a633fb8e7a009490c6002bf272eceaf317f27af6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 OLR1 CASZ1

2.35e-041583437960337d87afecf2692ab65e5991f052ceddfacc
ToppCell343B-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

OLR1 FGD3 ZXDB

2.53e-041623437860fab12893d2f589f91a89e33fbffeb4d6c56c
ToppCell343B-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

OLR1 FGD3 ZXDB

2.53e-04162343431dec235874245a0289aa1af98bdfb7ffe1c485
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRERF1 PLCB4 ZXDB

2.86e-04169343f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ATAD2 ZNF335 ZNF197

2.86e-04169343ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UBR1 PLCB4 SLC16A2

2.96e-04171343eddc5e05003382603ee49f74b9e2242a43021096
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZIK1 ATAD2 CCDC171

3.06e-041733439f892d756d05e573af018db64edb130ff187ad47
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 GRK3 ASAP1

3.06e-0417334373f858f2c45d19b9ec8d99ac02c91551790f670c
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAGL1 PLCB4 SEPTIN7

3.11e-041743439d22a554617a93701d0945de63cc3e7b24322c40
ToppCellsevere_COVID-19-HSPC|World / disease group, cell group and cell class (v2)

PLCB4 CCDC171 SLC16A2

3.27e-04177343289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCellMid-temporal_gyrus_(MTG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CCDC171 DNAH6 CCDC144A

3.33e-04178343ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLAGL1 DNAH6 FMN1

3.38e-04179343c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLAGL1 DNAH6 FMN1

3.38e-0417934353e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 FMN1 CASZ1

3.38e-04179343666072c0e8448dbaec1683d18368ec2502453f90
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FMN1 OLR1 CASZ1

3.50e-04181343e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ZFAT ZNF335 CCDC144A

3.73e-04185343636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellCOVID-19_Moderate-HSPC|COVID-19_Moderate / disease group, cell group and cell class

PLAGL1 PLCB4 CCDC171

3.73e-04185343cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 GRK3 ASAP1

3.79e-04186343305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

PLAGL1 PLCB4 CCDC171

3.97e-0418934396015439971e2e5b8d6294ca5a6b873c7774e925
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 FMN1 CASZ1

3.97e-041893437eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

PLCB4 CCDC171 SLC16A2

3.97e-041893432157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellmild-Myeloid-Immature_Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PAXBP1 ZNF280D OLR1

3.97e-0418934394dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCellAdult|World / Lineage, Cell type, age group and donor

FMN1 OLR1 CASZ1

3.97e-041893435cd285bfad973125d46d704fec18b21266a63379
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAGL1 PLCB4 SLC16A2

4.09e-041913430e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAGL1 PLCB4 SLC16A2

4.09e-04191343fcdf3a747038e346a467eae8b7c293592658b53f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC171 DNAH6 MAP3K19

4.09e-04191343a6c9df4cb4d09e0a91b3c8d7f3e091a7e95e6471
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 PLCB4 ASAP1

4.09e-041913437b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|lung / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.09e-04191343dab953682b8c9ed680a799161f837f792a7e4f33
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAGL1 PLCB4 SLC16A2

4.09e-0419134354bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 PLCB4 ASAP1

4.09e-04191343cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCellCOVID-19-lung-Macrophage_PPARGhi_CD5Lhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.15e-04192343bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

GRK3 FMN1 ASAP1

4.15e-04192343733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAGL1 PLCB4 SLC16A2

4.15e-04192343cd4c9b9ab17a779c154264f7459020f51e528ba5
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 FGD3

4.28e-04194343f09675cd472200363c458952f00d2e41990800ee
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAGL1 PLCB4 ASAP1

4.28e-04194343e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRK2 GRK3 FGD3

4.28e-04194343e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRK2 GRK3 FGD3

4.28e-041943430bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAGL1 ZFAT SEPTIN7

4.35e-0419534355b4030f078173b0136990fae87b6eaf44c58f33
ToppCellIPF-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

FMN1 OLR1 ASAP1

4.35e-0419534350edda117b438b9c3616191884007466f6d974f0
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAGL1 ZFAT SEPTIN7

4.35e-0419534319347b7e8d3ea67e0fddd948078abcab9d364a2d
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.35e-04195343148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

GRK3 OLR1 ASAP1

4.35e-0419534355e25f702af19146a161861cfd15f40bbda1dc35
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRK3 FMN1 OLR1

4.35e-0419534362dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCellCOVID-19_Mild-PLT_5|COVID-19_Mild / Disease Group and Platelet Clusters

TRERF1 FMN1 BMS1

4.35e-04195343bdf9a6ea1bd83c72a834c45f86ce3f4643a9bef3
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

GRK2 GRK3 FMN1

4.41e-04196343f245e929a286cb097130572e1027b4f01be8b04d
ToppCellAdult-Immune-monocyte|Adult / Lineage, Cell type, age group and donor

GRK2 GRK3 FGD3

4.41e-041963433ef193c5180de3137daf886492e74fc574bc9767
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.41e-041963431b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

GRK2 GRK3 FMN1

4.41e-0419634315397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.41e-041963437026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellCOVID-19-Myeloid-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

GRK3 FMN1 OLR1

4.41e-041963434929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCellIPF-Myeloid-Macrophage|IPF / Disease state, Lineage and Cell class

FMN1 OLR1 ASAP1

4.48e-04197343a2ffb33c7cad6be43cbb8ed9a91338923cc07db4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GRK3 FMN1 FGD3

4.48e-04197343c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

GRK3 OLR1 ASAP1

4.54e-041983439bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D231|Adult / Lineage, Cell type, age group and donor

GRK3 OLR1 ASAP1

4.54e-0419834379a415e19cedde13a88f5043d71557363f102322
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 FGD3

4.54e-04198343ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellCOVID-19-Myeloid|COVID-19 / group, cell type (main and fine annotations)

GRK3 FMN1 OLR1

4.54e-0419834333f0a919188a67d2a876b52c61a1cec2c9747969
ToppCellCOVID-19-kidney-Macrophages|kidney / Disease (COVID-19 only), tissue and cell type

GRK3 FMN1 OLR1

4.54e-04198343161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

GRK2 GRK3 FGD3

4.54e-04198343d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellCOVID-19-Myeloid-Alveolar_macrophages|COVID-19 / group, cell type (main and fine annotations)

GRK3 FMN1 OLR1

4.61e-04199343e1c85ca85fa22c4a4fa1bbdf55304bf3628485ee
ToppCellCTRL-Myeloid|CTRL / Disease state, Lineage and Cell class

GRK3 OLR1 ASAP1

4.61e-0419934370b89a930709fdb91fde6f96106add8455b11618
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRERF1 GRK3 ASAP1

4.61e-04199343c6da5c517dbcfa621fa6dda9e0c1985ba2f3bbdb
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRERF1 GRK3 ASAP1

4.61e-04199343b9613e88c4b752529d6ae20857744418207b0830
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC|GW12 / Sample Type, Dataset, Time_group, and Cell type.

PAXBP1 SLC16A2 DNAH6

4.68e-042003434db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related|GW12 / Sample Type, Dataset, Time_group, and Cell type.

PAXBP1 SLC16A2 DNAH6

4.68e-04200343d46a19274c2836ce7494790ce513764dedcadc79
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLCB4 FMN1 CASZ1

4.68e-04200343c450a15e21fa72d071ed6e3b9f22de557a0f3cea
Drugzosuquidar

MRPS7 PPIG ABCC6

3.41e-0620343CID000153997
Drugsulprostone

PLCB3 PLCB4 GRK2 GRK3

3.75e-0671344CID005312153
DrugIsoflupredone acetate [338-98-7]; Down 200; 9.6uM; HL60; HT_HG-U133A

PLCB4 GRK2 OLR1 ZNF335 ZNF197

9.47e-061933451873_DN
DrugAC1OAGKW

PLCB3 PLCB4 GRK2 GRK3 ASAP1

9.47e-06193345CID006857413
DrugPl-cs

PPIG PLCB3 PLCB4 GRK2

1.92e-05107344CID006450086
Drugbenzbromarone

MRPS7 PPIG ABCC6

2.28e-0537343CID000002333
Drug1d3q

GRK2 GRK3 OLR1

2.89e-0540343CID000001635
DrugbetaARKct

GRK2 GRK3

3.23e-056342CID000002295
DrugSKF83742

PLCB3 PLCB4

3.23e-056342CID000130828
DrugC10A

PLCB3 PLCB4

3.23e-056342CID000041624
DrugDesipramine

GRK2 GRK3 SLC16A2

4.72e-0547343ctd:D003891
Drugtriphosphoinositide

PLCB3 PLCB4 GRK2 GRK3 ASAP1

5.00e-05273345CID009543520
DrugNem-S-G

MRPS7 ABCC6

6.03e-058342CID000126950
Drugtangeretin

MRPS7 PPIG OLR1

7.16e-0554343CID000068077
Drugmilrinone

PLCB3 PLCB4 GRK2 GRK3

7.20e-05150344CID000004197
DrugSCT-1

GRK2 GRK3

7.74e-059342CID000211458
Drug1-chlorobutane

TRERF1 PPIG

7.74e-059342CID000008005
Drugacetaminophen glucuronide

MRPS7 PPIG ABCC6

9.34e-0559343CID000083944
Drug2-(aminomethyl)pyrrolidine

PLCB3 PLCB4 GRK2 GRK3

9.47e-05161344CID000072032
Drug3-nitrocoumarin

PLCB3 PLCB4

9.67e-0510342CID002799766
DrugGDP-b-S

PLCB3 PLCB4 GRK2 GRK3

9.70e-05162344CID000643998
Druganthraquinone

GRK2 SLC16A2 CSNK1G3

9.82e-0560343CID000006780
Drugisopetasin

PLCB3 PLCB4

1.18e-0411342CID005318627
DrugAC1L986B

TRERF1 PPIG

1.18e-0411342CID000439854
DrugAC1L85AO

MRPS7 PPIG ABCC6

1.31e-0466343CID000372705
DrugAC1L1II7

PLCB3 PLCB4

1.42e-0412342CID000004589
Drugfenoldopam

PLCB3 PLCB4 GRK2

1.56e-0470343CID000003340
Drug4-isopropylaniline

GRK2 GRK3 ASAP1

1.62e-0471343CID000007464
Druggeranyl nitrile

GRK2 GRK3

1.67e-0413342CID000021768
DrugAC1Q3V55

MRPS7 PPIG

1.67e-0413342CID000115317
DrugAC1MU1S9

PLCB3 PLCB4 GRK2 GRK3 OLR1 ZNF335

1.81e-04572346CID000003733
Drugp,p'-DDA

GRK2 GRK3 ABCC6

1.83e-0474343CID000006730
DrugAC1MQNLW

PLCB3 PLCB4

1.95e-0414342CID003504628
Drug8-N3cAMP

GRK2 GRK3

1.95e-0414342CID006426627
Drug8-(6-aminohexyl)amino cyclic AMP

GRK2 GRK3

1.95e-0414342CID000161999
DrugSecurinine [5610-40-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A

PLCB3 GRK3 ZNF280D CASZ1

1.98e-041953443470_DN
DrugGi-2

PLCB3 PLCB4 GRK2 GRK3

1.98e-04195344CID011957432
DrugCalycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A

PLCB3 GRK2 GRK3 ZNF335

2.02e-041963442764_DN
DrugMetronidazole [443-48-1]; Up 200; 23.4uM; MCF7; HT_HG-U133A

CCNT1 PLAGL1 GRK2 SEPTIN7

2.06e-041973441503_UP
DrugLymecycline [992-21-2]; Down 200; 6.6uM; MCF7; HT_HG-U133A

PLCB3 GRK2 GRK3 ZNF335

2.06e-041973443514_DN
Drug2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A

PAXBP1 GRK3 ZNF280D ZNF335

2.06e-041973446974_DN
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

PLAGL1 CASZ1 ASAP1 ZNF197

2.10e-041983446992_UP
DrugNA-382

GRK2 GRK3

2.25e-0415342CID000132534
Drugoxotremorine-M

PLCB3 PLCB4 GRK3

2.40e-0481343CID000004629
Drugglibenclamide

MRPS7 PPIG GRK2 GRK3 ABCC6

2.41e-04382345CID000003488
Drugm-3M3FBS

PLCB3 PLCB4

2.56e-0416342CID000761523
Drugperoxylinolenic acid

PPIG OLR1

2.56e-0416342CID006439905
DrugAC1L4BIC

MRPS7 ABCC6

2.56e-0416342CID000153998
Drugsulfinpyrazone

MRPS7 SLC16A2 ABCC6

2.96e-0487343CID000005342
DrugK 252

AKAP11 GRK2 GRK3

3.06e-0488343CID000003813
DrugAC-759

UBR1 MRPS7 ABCC6

3.06e-0488343CID000005396
Drug8-azido cyclic AMP

GRK2 GRK3

3.26e-0418342CID000115296
DrugH-9 dihydrochloride

CCNT1 GRK2 GRK3

3.27e-0490343CID000003544
Drug8-thiomethyl-cAMP

GRK2 GRK3

3.64e-0419342CID000093140
Drug8-azidoadenosine

GRK2 GRK3

3.64e-0419342CID000160751
Drugsapintoxin A

PLCB3 PLCB4

3.64e-0419342CID000108085
DrugNSC-351907

PLCB3 PLCB4 GRK2 GRK3

3.65e-04229344CID000004016
DrugAraf-TC

PLCB3 PLCB4 ABCC6

3.72e-0494343CID000100788
DrugUTP-NA

CCNT1 PLCB3 PLCB4 GRK2 GRK3

3.73e-04420345CID000001181
DrugTCPOBOP

MRPS7 PPIG ABCC6

3.83e-0495343CID000005382
Drugisorhamnetin

TRERF1 OLR1

4.04e-0420342CID005281654
Drug3 -hydroxypregn-5-en-20-one

TRERF1 PPIG GRK2 GRK3

4.22e-04238344CID000001027
Drugorthovanadate

MRPS7 GRK2 GRK3 OLR1 ABCC6

4.38e-04435345CID000061672
DrugAC1Q6BAJ

MRPS7 PPIG

4.47e-0421342CID000125675
Drugvinylene

ZFAT ABCC6 ZNF335 ZNF197

4.71e-04245344CID000006326
DrugAC1Q5X3R

MRPS7 ABCC6

4.91e-0422342CID000108075
DrugSp-8-Cl-cAMPS

GRK2 GRK3

4.91e-0422342CID000133987
DiseaseParkinson's disease (biomarker_via_orthology)

GRK2 GRK3

4.86e-0430322DOID:14330 (biomarker_via_orthology)
Diseaseprogressive supranuclear palsy

ASAP1 BMS1

5.20e-0431322MONDO_0019037
Diseaselobe attachment

FMN1 ASAP1 FGD3

1.45e-03207323EFO_0007667
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

PLCB3 ZNF280D ZNF335

1.82e-03224323EFO_0004530, EFO_0008317
Diseasehypertension (biomarker_via_orthology)

GRK2 GRK3 OLR1

1.89e-03227323DOID:10763 (biomarker_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

UBR1 PLCB3 ZNF335

2.19e-03239323EFO_0008317, EFO_0020945
Diseasered blood cell density measurement

PLCB3 ZFAT FMN1 ABCC6 CASZ1

2.41e-03880325EFO_0007978
DiseaseCardiomyopathies, Primary

GRK2 OLR1

2.55e-0369322C0033141
DiseaseMyocardial Diseases, Secondary

GRK2 OLR1

2.55e-0369322C0036529
Diseasecongestive heart failure (is_marker_for)

GRK2 GRK3

3.58e-0382322DOID:6000 (is_marker_for)
Diseaseserum iron measurement

ZFAT ASAP1

3.93e-0386322EFO_0006332
Diseasenevus count, cutaneous melanoma

FMN1 ASAP1

4.39e-0391322EFO_0000389, EFO_0004632
Diseasehypertension

PLCB3 ZFAT CASZ1

4.42e-03307323EFO_0000537
Diseasephospholipid measurement, intermediate density lipoprotein measurement

CSNK1G3 ZNF335

5.18e-0399322EFO_0004639, EFO_0008595
Diseasecoronary artery disease (is_implicated_in)

OLR1 ABCC6

5.28e-03100322DOID:3393 (is_implicated_in)
DiseaseLeft-Sided Heart Failure

GRK2 OLR1

6.35e-03110322C0023212
DiseaseMyocardial Failure

GRK2 OLR1

6.35e-03110322C1959583
DiseaseHeart Failure, Right-Sided

GRK2 OLR1

6.35e-03110322C0235527
DiseaseCongestive heart failure

GRK2 OLR1

6.35e-03110322C0018802
DiseaseHeart failure

GRK2 OLR1

6.35e-03110322C0018801
DiseaseHeart Decompensation

GRK2 OLR1

6.35e-03110322C1961112

Protein segments in the cluster

PeptideGeneStartEntry
TCKEKMDHKTQHHRT

ZNF280D

486

Q6N043
FRQHKTKDKHEIDRM

GRK3

391

P35626
SQMDSHKRKHEKQER

CASZ1

1586

Q86V15
KHQREKNEMESHIRE

CCDC171

186

Q6TFL3
MFSNKEHHQEADKKR

AKAP11

1411

Q9UKA4
HRKDHDKTSLIQKME

ATAD2

1366

Q6PL18
KMRIKVHAAADKHNS

CCNT1

481

O60563
TVHSQKMKKAKEQRH

BMS1

1216

Q14692
FRQHKTKDKHEIDRM

GRK2

391

P25098
HQRMFKKEQRDSSKD

SLC16A2

501

P36021
KKEHKMEESHLENAQ

FMN1

1311

Q68DA7
NHSNAAIRKVEKMHK

FGD3

336

Q5JSP0
SMKELHKTNRQQHEK

PAXBP1

401

Q9Y5B6
RKLNEKSKEQMELHH

OLR1

111

P78380
NREAHQHRDKMQQSK

CSNK1G3

346

Q9Y6M4
KERDSKHNRNEEKRM

PPIG

471

Q13427
KRHNSISEAKMRDKH

PLCB3

1101

Q01970
KHEDKHMRQEKEAAH

DNAH6

3466

Q9C0G6
KDTFNKMAHRKRHSV

LINC00032

16

P0C843
EKEKREHAKQHGMIR

ASAP1

181

Q9ULH1
KKMNSEISHRHQKEK

CCDC144A

801

A2RUR9
NDKHKMNSHRSKLDS

MAP3K19

526

Q56UN5
KRKHDLHKMAEANRA

MRPS7

221

Q9Y2R9
RHTKKTHSQELMKES

PLAGL1

201

Q9UM63
KLSHDRESKEMRAHQ

PLCB4

1066

Q15147
KKRNHHQEEQMRQKD

ABCC6

471

O95255
HRESKMEHLAQLRKK

RRP7A

246

Q9Y3A4
TSMSKLLRHKRKHDD

ZXDB

466

P98169
KSNLKAHMNRHSTEK

ZFAT

921

Q9P243
KSNFIDHKRMHSREK

ZNF197

606

O14709
DTATHNVHEEKMKNK

SAGE2P

386

A6NJ88
RRHEQMKKNLEAQHK

SEPTIN7

381

Q16181
QKHHSAKKSLKRDMD

ZIK1

136

Q3SY52
TQHSKAEHMQKKRRK

UBR1

841

Q8IWV7
NKKDLRRHMLTHTKE

ZNF335

1086

Q9H4Z2
FKIKSRNAHMKTHRQ

TRERF1

1096

Q96PN7