Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN3A SCN9A	3.83e-06	14	45	3	GO:0031402
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN2A SCN3A SCN9A	2.68e-05	26	45	3	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN2A SCN3A SCN9A	2.68e-05	26	45	3	GO:0031420
GeneOntologyMolecularFunction	sodium channel activity	SCN2A SCN3A SCN9A	2.19e-04	52	45	3	GO:0005272
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKD3 PRKD2	5.84e-04	16	45	2	GO:0004697
GeneOntologyBiologicalProcess	mucociliary clearance	SPAG16 SPAG6 DNAH9	2.55e-06	13	44	3	GO:0120197
GeneOntologyBiologicalProcess	cerebrospinal fluid circulation	SPAG16 SPAG6 DNAH9	1.01e-05	20	44	3	GO:0090660
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN2A SCN3A SCN9A	6.16e-05	36	44	3	GO:0086010
GeneOntologyBiologicalProcess	respiratory system process	SPAG16 SPAG6 DNAH9	2.20e-04	55	44	3	GO:0003016
GeneOntologyBiologicalProcess	epithelial cilium movement involved in extracellular fluid movement	SPAG16 SPAG6 DNAH9	2.71e-04	59	44	3	GO:0003351
GeneOntologyBiologicalProcess	extracellular transport	SPAG16 SPAG6 DNAH9	3.14e-04	62	44	3	GO:0006858
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN2A SCN3A SCN9A	3.14e-04	62	44	3	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN2A SCN3A SCN9A	3.29e-04	63	44	3	GO:0019228
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN2A SCN3A SCN9A	5.80e-06	17	44	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN2A SCN3A SCN9A	3.06e-05	29	44	3	GO:0034706
GeneOntologyCellularComponent	axonemal central apparatus	SPAG16 SPAG6	6.46e-05	6	44	2	GO:1990716
Domain	Na_trans_cytopl	SCN2A SCN3A SCN9A	2.60e-07	6	45	3	PF11933
Domain	Na_trans_cytopl	SCN2A SCN3A SCN9A	2.60e-07	6	45	3	IPR024583
Domain	Na_channel_asu	SCN2A SCN3A SCN9A	1.55e-06	10	45	3	IPR001696
Domain	Na_trans_assoc	SCN2A SCN3A SCN9A	1.55e-06	10	45	3	IPR010526
Domain	Na_trans_assoc	SCN2A SCN3A SCN9A	1.55e-06	10	45	3	PF06512
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD2	1.70e-05	3	45	2	IPR015727
Domain	Channel_four-helix_dom	SCN2A SCN3A SCN9A	3.49e-04	57	45	3	IPR027359
Domain	-	SCN2A SCN3A SCN9A	3.49e-04	57	45	3	1.20.120.350
Domain	IQ	SCN2A SCN3A SCN9A	9.78e-04	81	45	3	SM00015
Domain	DAG/PE-bd	PRKD3 PRKD2	1.16e-03	21	45	2	IPR020454
Domain	ARM-type_fold	FMNL3 ARMH3 TRRAP SPAG6 KPNB1	1.29e-03	339	45	5	IPR016024
Domain	IQ_motif_EF-hand-BS	SCN2A SCN3A SCN9A	1.33e-03	90	45	3	IPR000048
Domain	IQ	SCN2A SCN3A SCN9A	1.46e-03	93	45	3	PS50096
Domain	Arm	SPAG6 KPNB1	2.52e-03	31	45	2	PF00514
Domain	Ion_trans_dom	SCN2A SCN3A SCN9A	2.61e-03	114	45	3	IPR005821
Domain	Ion_trans	SCN2A SCN3A SCN9A	2.61e-03	114	45	3	PF00520
Domain	ARM	SPAG6 KPNB1	4.18e-03	40	45	2	SM00185
Domain	PH	PRKD3 PRKD2 ARHGEF1 ITK	4.43e-03	278	45	4	SM00233
Domain	PH_DOMAIN	PRKD3 PRKD2 ARHGEF1 ITK	4.49e-03	279	45	4	PS50003
Domain	PH_domain	PRKD3 PRKD2 ARHGEF1 ITK	4.55e-03	280	45	4	IPR001849
Domain	GPCR_Rhodpsn_7TM	HCAR3 OR2M3 OR2M7 OR2M2 ACKR4 OR7C1	5.16e-03	670	45	6	IPR017452
Domain	7tm_1	HCAR3 OR2M3 OR2M7 OR2M2 ACKR4 OR7C1	5.42e-03	677	45	6	PF00001
Domain	Armadillo	SPAG6 KPNB1	5.73e-03	47	45	2	IPR000225
Domain	-	AGO4 TOE1	5.73e-03	47	45	2	3.30.420.10
Domain	G_PROTEIN_RECEP_F1_1	HCAR3 OR2M3 OR2M7 OR2M2 ACKR4 OR7C1	5.74e-03	685	45	6	PS00237
Domain	HEAT	SPAG6 KPNB1	5.97e-03	48	45	2	PF02985
Domain	G_PROTEIN_RECEP_F1_2	HCAR3 OR2M3 OR2M7 OR2M2 ACKR4 OR7C1	5.98e-03	691	45	6	PS50262
Domain	GPCR_Rhodpsn	HCAR3 OR2M3 OR2M7 OR2M2 ACKR4 OR7C1	6.02e-03	692	45	6	IPR000276
Domain	C1_1	PRKD3 PRKD2	8.33e-03	57	45	2	PF00130
Domain	HEAT	SPAG6 KPNB1	8.61e-03	58	45	2	IPR000357
Domain	ZF_DAG_PE_1	PRKD3 PRKD2	1.04e-02	64	45	2	PS00479
Domain	ZF_DAG_PE_2	PRKD3 PRKD2	1.04e-02	64	45	2	PS50081
Domain	C1	PRKD3 PRKD2	1.07e-02	65	45	2	SM00109
Domain	PE/DAG-bd	PRKD3 PRKD2	1.10e-02	66	45	2	IPR002219
Domain	RNaseH-like_dom	AGO4 TOE1	1.20e-02	69	45	2	IPR012337
Domain	IQ	SCN3A SCN9A	1.27e-02	71	45	2	PF00612
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN2A SCN3A SCN9A	4.15e-05	31	31	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN2A SCN3A SCN9A	4.57e-05	32	31	3	M27455
Pathway	REACTOME_SENSORY_PERCEPTION	OR2M3 PDE6A OR2M7 OR2M2 OR7C1 SCN2A SCN3A SCN9A	5.15e-05	636	31	8	M41834
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	SCN2A SCN3A SCN9A	1.46e-04	47	31	3	M42524
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY	PRKD3 PRKD2	4.83e-04	15	31	2	M47816
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A SCN9A	2.02e-09	3	45	3	19284629
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M3 OR2M7 OR2M2	8.09e-09	4	45	3	15377787
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN2A SCN3A SCN9A	2.02e-08	5	45	3	8812438
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN2A SCN3A SCN9A	4.04e-08	6	45	3	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN2A SCN3A SCN9A	1.69e-07	9	45	3	16382098
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN2A SCN3A SCN9A	5.74e-07	13	45	3	15123669
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	1.64e-06	2	45	2	20346423
Pubmed	Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.	PRKD3 PRKD2	1.64e-06	2	45	2	24840177
Pubmed	Distribution of sperm antigen 6 (SPAG6) and 16 (SPAG16) in mouse ciliated and non-ciliated tissues.	SPAG16 SPAG6	1.64e-06	2	45	2	30911868
Pubmed	Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.	PRKD3 PRKD2	1.64e-06	2	45	2	30841931
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	1.64e-06	2	45	2	11245985
Pubmed	A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme.	SPAG16 SPAG6	1.64e-06	2	45	2	17699735
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	1.64e-06	2	45	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	1.64e-06	2	45	2	27153334
Pubmed	Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.	SCN3A SCN9A	1.64e-06	2	45	2	25172946
Pubmed	Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.	PRKD3 PRKD2	1.64e-06	2	45	2	25802335
Pubmed	Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.	PRKD3 PRKD2	1.64e-06	2	45	2	23393329
Pubmed	A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.	SPAG16 SPAG6	1.64e-06	2	45	2	12391165
Pubmed	Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.	PRKD3 PRKD2	1.64e-06	2	45	2	37044359
Pubmed	Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins.	SPAG16 SPAG6	1.64e-06	2	45	2	17323374
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD2	4.91e-06	3	45	2	26253275
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN2A SCN3A	4.91e-06	3	45	2	12610651
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD2	4.91e-06	3	45	2	16377259
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN3A SCN9A	4.91e-06	3	45	2	33895391
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN2A SCN3A	4.91e-06	3	45	2	23859570
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN3A SCN9A	4.91e-06	3	45	2	19699781
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD2	4.91e-06	3	45	2	27662904
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD2	4.91e-06	3	45	2	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD2	4.91e-06	3	45	2	26426580
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN2A SCN3A	4.91e-06	3	45	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN2A SCN3A	4.91e-06	3	45	2	17544618
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	4.91e-06	3	45	2	16052353
Pubmed	Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.	SPAG16 SPAG6	4.91e-06	3	45	2	25333478
Pubmed	The nuclear import of protein kinase D3 requires its catalytic activity.	PRKD3 KPNB1	4.91e-06	3	45	2	16380377
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN2A SCN3A	4.91e-06	3	45	2	14973256
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD2	4.91e-06	3	45	2	38419169
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN2A SCN3A	9.81e-06	4	45	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN2A SCN3A	9.81e-06	4	45	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN2A SCN3A	9.81e-06	4	45	2	29578003
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD2	9.81e-06	4	45	2	14743217
Pubmed	The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.	HCAR3 NLRP3	9.81e-06	4	45	2	25686106
Pubmed	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.	PRKD3 PRKD2	9.81e-06	4	45	2	27670070
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN2A SCN3A	9.81e-06	4	45	2	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN2A SCN3A	9.81e-06	4	45	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN2A SCN3A	1.63e-05	5	45	2	1679748
Pubmed	Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.	HCAR3 NLRP3	1.63e-05	5	45	2	25828455
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN3A SCN9A	1.63e-05	5	45	2	22875929
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A	1.63e-05	5	45	2	17724025
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD2	1.63e-05	5	45	2	22228765
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN2A SCN3A	1.63e-05	5	45	2	24337656
Pubmed	Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.	SCN3A SCN9A	2.45e-05	6	45	2	9143501
Pubmed	Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.	HCAR3 NLRP3	2.45e-05	6	45	2	29937375
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN3A SCN9A	3.42e-05	7	45	2	24440715
Pubmed	Analysis of the sperm flagellar axoneme using gene-modified mice.	SPAG16 SPAG6	4.56e-05	8	45	2	32554934
Pubmed	Significant determinants of mouse pain behaviour.	SCN3A SCN9A	4.56e-05	8	45	2	25101983
Pubmed	Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.	SCN3A SCN9A	5.86e-05	9	45	2	8854872
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN2A SCN3A	5.86e-05	9	45	2	15746173
Pubmed	The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners.	TRRAP KPNB1	7.32e-05	10	45	2	15870280
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN2A SCN3A	1.07e-04	12	45	2	8169823
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN2A SCN3A	1.07e-04	12	45	2	30175250
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	LMTK3 TRRAP	1.47e-04	14	45	2	28263302
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN2A SCN3A	1.70e-04	15	45	2	9726281
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	SF3A3 FMNL3 TRRAP ARHGEF1 PTCD3	1.84e-04	410	45	5	26949251
Pubmed	BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma.	PRKD2 KPNB1	3.06e-04	20	45	2	32509391
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TRRAP TOE1 DNMT1 KPNB1 PTCD3	3.42e-04	469	45	5	27634302
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SF3A3 LMTK3 TRRAP LRCH1 TOE1 KPNB1 PTCD3	4.47e-04	1082	45	7	38697112
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	PRKD3 PRKD2 LPCAT3	4.63e-04	116	45	3	30652415
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	PIGN TRRAP LRCH1 EPM2AIP1	6.59e-04	306	45	4	18973680
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2M3 OR2M7 OR2M2 OR7C1	9.75e-04	340	45	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2M3 OR2M7 OR2M2 OR7C1	9.75e-04	340	45	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2M3 OR2M7 OR2M2 OR7C1	1.01e-03	343	45	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2M3 OR2M7 OR2M2 OR7C1	1.04e-03	346	45	4	14611657
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PRKD3 PRKD2 AGO4 TRRAP ITK EPM2AIP1	1.08e-03	910	45	6	36736316
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SF3A3 PIGN LRCH1 TOE1 DNMT1 KPNB1 PTCD3	1.08e-03	1257	45	7	36526897
Cytoband	1q44	OR2M3 OR2M7 OR2M2 NLRP3	4.31e-06	110	45	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M3 OR2M7 OR2M2 NLRP3	7.86e-06	128	45	4	chr1q44
Cytoband	2q24	SCN3A SCN9A	5.14e-05	11	45	2	2q24
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN2A SCN3A SCN9A	2.69e-04	127	45	3	chr2q24
Cytoband	19p13.1	B3GNT3 OR7C1	1.03e-03	48	45	2	19p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	B3GNT3 OR7C1 EVI5L DNMT1 KLHL26	1.07e-03	797	45	5	chr19p13
Cytoband	13q34	ATP11A RAB20	1.30e-03	54	45	2	13q34
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	SF3A3 AGO4 TOE1	3.02e-03	294	45	3	chr1p34
Cytoband	Ensembl 112 genes in cytogenetic band chr13q34	ATP11A RAB20	3.41e-03	88	45	2	chr13q34
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN3A SCN9A	6.04e-07	9	36	3	1203
GeneFamily	Olfactory receptors, family 2	OR2M3 OR2M7 OR2M2	1.46e-03	113	36	3	149
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SPAG6 KPNB1	3.31e-03	43	36	2	409
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PRKD3 PRKD2 ITK	7.89e-03	206	36	3	682
Coexpression	GSE3982_NEUTROPHIL_VS_NKCELL_UP	PRKD2 ATP11A AGO4 RAB20 NLRP3	1.83e-05	199	43	5	M5530
Coexpression	GSE35825_IFNA_VS_IFNG_STIM_MACROPHAGE_DN	PRKD2 SCN3A DNMT1 KPNB1 PTCD3	1.87e-05	200	43	5	M8656
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KCNT2 STXBP5L SCN2A SCN3A SCN9A	1.75e-06	200	45	5	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.18e-05	179	45	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPAG16 SCN2A SCN3A ATP6V0A4	3.46e-05	183	45	4	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.46e-05	183	45	4	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH9 STXBP5L SCN2A SCN9A	3.54e-05	184	45	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH9 STXBP5L SCN2A SCN9A	3.54e-05	184	45	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH9 STXBP5L SCN2A SCN9A	3.54e-05	184	45	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.85e-05	188	45	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.85e-05	188	45	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.93e-05	189	45	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRCH1 SCN2A SCN3A ATP6V0A4	3.93e-05	189	45	4	975c0f079903ae36b0ffa54e86294d42ec7697de
Drug	sodium	PRKD3 PRKD2 HCAR3 ATP11A KCNT2 SCN2A SCN3A SLC22A5 ATP6V0A4 DNMT1 SCN9A	1.28e-06	944	44	11	CID000000923
Drug	Zonisamide	SCN2A SCN3A SCN9A	4.49e-06	17	44	3	DB00909
Drug	Scorpion Venoms	SCN2A SCN3A SCN9A	5.38e-06	18	44	3	ctd:D012604
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN3A SCN9A	1.09e-05	3	44	2	ctd:C561228
Drug	procaine	PRKD3 PRKD2 HCAR3 SCN3A SCN9A	1.13e-05	153	44	5	CID000004914
Drug	tetradotoxin	PRKD3 PRKD2 HCAR3 ADCYAP1R1 SCN2A SCN3A SCN9A	1.66e-05	428	44	7	CID000020382
Drug	toluene	PRKD3 PRKD2 SCN3A KPNB1 SCN9A	2.16e-05	175	44	5	CID000001140
Drug	tetracaine	PRKD3 PRKD2 HCAR3 SCN9A	2.51e-05	88	44	4	CID000005411
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	PRKD3 PIGN B3GNT3 LRCH1 LPCAT3	3.90e-05	198	44	5	5334_UP
Drug	verapamil	PRKD3 PRKD2 HCAR3 KCNT2 SCN3A SLC22A5 SCN9A	3.94e-05	490	44	7	CID000002520
Drug	benzocaine	SCN2A SCN3A SCN9A	5.00e-05	37	44	3	CID000002337
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A	5.45e-05	6	44	2	ctd:C475726
Drug	fenpropathrin	SCN2A SCN3A	5.45e-05	6	44	2	ctd:C044267
Drug	Tetrodotoxin	SCN2A SCN3A SCN9A	6.33e-05	40	44	3	ctd:D013779
Drug	pentobarbital	PRKD3 PRKD2 HCAR3 SCN3A SCN9A	7.00e-05	224	44	5	CID000004737
Drug	benzoyl	PRKD3 PRKD2 SCN9A	7.87e-05	43	44	3	CID000007187
Drug	pilsicainide	HCAR3 SCN3A SCN9A	9.65e-05	46	44	3	CID000004820
Drug	NPC 15437	PRKD3 PRKD2 ADCYAP1R1	9.65e-05	46	44	3	CID000004548
Drug	bupivacaine	PRKD3 PRKD2 SCN3A SCN9A	9.92e-05	125	44	4	CID000002474
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A	1.01e-04	8	44	2	ctd:C489827
Drug	maleimide	PRKD3 PRKD2 PDE6A SCN2A	1.19e-04	131	44	4	CID000010935
Drug	myo-inositol	PRKD3 PIGN PRKD2 ATP11A TRRAP ARHGEF1 ADCYAP1R1 ITK	1.42e-04	811	44	8	CID000000892
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN3A SCN9A	3.43e-07	10	43	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN3A SCN9A	3.43e-07	10	43	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN3A SCN9A	6.28e-07	12	43	3	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN3A SCN9A	4.35e-06	22	43	3	DOID:2030 (implicated_via_orthology)
Disease	Hereditary Sensory Autonomic Neuropathy, Type 2	DNMT1 SCN9A	2.07e-05	5	43	2	C0020072
Disease	Sensory Neuropathy, Hereditary	DNMT1 SCN9A	3.10e-05	6	43	2	C0699739
Disease	Gastric Adenocarcinoma	PRKD2 TRRAP ITK	3.92e-05	45	43	3	C0278701
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	DNMT1 SCN9A	4.34e-05	7	43	2	C0020075
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN2A SCN9A	7.42e-05	9	43	2	C3502809
Disease	epilepsy (implicated_via_orthology)	KCNT2 SCN2A SCN3A SCN9A	9.36e-05	163	43	4	DOID:1826 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN2A SCN9A	1.60e-04	13	43	2	C0751122
Disease	Epilepsy	KCNT2 SCN2A SCN9A	5.43e-04	109	43	3	C0014544
Disease	obsolete_red blood cell distribution width	SF3A3 HCAR3 ATP11A LRCH1 LPCAT3 NLRP3 SLC22A5 KPNB1	6.43e-04	1347	43	8	EFO_0005192

Protein segments in the cluster

Peptide	Gene	Start	Entry
PEEEAFCVFVRLMQE	EVI5L	211	Q96CN4
MAECLFFPLEELQNI	ARHGEF1	446	Q92888
PLELFLVDECEDMQL	DNMT1	811	P26358
RPLVCAVLDLMVEFI	ARMH3	441	Q5T2E6
RAQPIIEFMCEVLDI	AGO4	216	Q9HCK5
DLLFETLFDLVVPMI	RAB20	191	Q9NX57
QMLEICIGFVVPFLI	ACKR4	201	Q9NPB9
FFDLICLMEQIDVTL	PTCD3	461	Q96EY7
PEIFREASVCMQLLF	MAGEA11	261	P43364
VETLPFLLIMEFCQL	LMTK3	201	Q96Q04
EEVIFICCIVMLVFP	OR2M2	196	Q96R28
EKILFICCIVMIVFP	OR2M3	196	Q8NG83
EEVIFICCIVMLVFP	OR2M7	196	Q8NG81
LEDCLVMPDQEIVFP	PDE6A	121	P16499
VNLECMFETPEKVFV	PRKD2	611	Q9BZL6
VNLECMFETPERVFV	PRKD3	636	O94806
EVPMELCHFVSLEIL	LRCH1	111	Q9Y2L9
LVCFQMEFLIVIVER	LPCAT3	381	Q6P1A2
AMICVALVVLPIQFE	KCNT2	261	Q6UVM3
IEMCEEFALPYVIVL	GTPBP8	211	Q8N3Z3
EMVLVSCPELFRIFN	ADCYAP1R1	71	P41586
EMEIPHFFCDLLEVL	OR7C1	171	O76099
VFLQMLPVVELCEEF	KLHL26	141	Q53HC5
VYQCMEVLLREVLPE	EPM2AIP1	121	Q7L775
QTLPVDFVECLMRFL	FMNL3	671	Q8IVF7
DIFPIDDVFLGMCLE	B3GNT3	291	Q9Y2A9
IPFCDEVMQLLLENL	KPNB1	686	Q14974
VVPDFELICEIMLVA	DNAH9	1996	Q9NYC9
DIFVNCFLSAMVEVP	SLC22A5	371	O76082
LEQAPICLVFEFMEH	ITK	426	Q08881
ENEVLFTMCFIPLVC	NLRP3	401	Q96P20
MVVEAEIFPVVLTCL	SPAG6	246	O75602
FEDFEFPNKVVLMCI	SLC35F5	386	Q8WV83
VADFLLIICLPFVMD	HCAR3	71	P49019
CIYFIVMDPFVDLAI	SCN9A	736	Q15858
VMDPFVDLAITICIV	SCN9A	741	Q15858
IVMDPFVDLAITICI	SCN3A	756	Q9NY46
TCEIVEEDPFAIQMI	STXBP5L	506	Q9Y2K9
IVMVKEDETFPCDLI	ATP11A	151	P98196
PEVIEDFLCNFLIKM	SPAG16	106	Q8N0X2
VMDPFVDLAITICIV	SCN2A	756	Q99250
VEEFLFCEPLQLSMK	ZBED8	201	Q8IZ13
LIPFVLVMCAFEAVQ	PIGN	836	O95427
NIILQFIPEMIFILC	ATP6V0A4	571	Q9HBG4
EICVPMSVEFEELLK	SF3A3	101	Q12874
QFIPCMDKLFDESIL	TRRAP	346	Q9Y4A5
FNLTLLCMEEYVIEP	TOE1	121	Q96GM8