Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DYNC1H1 DNAH11

2.84e-0518673GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DYNC1H1 DNAH11

1.11e-0428673GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DYNC1H1 DNAH11

2.59e-0437673GO:0045505
GeneOntologyMolecularFunctionsmall GTPase binding

SGSM1 RAB3GAP2 PPP6R1 SYTL1 DENND1A CDC42EP1

7.21e-04321676GO:0031267
DomainDynein_HC_stalk

DNHD1 DYNC1H1 DNAH11

1.36e-0514643IPR024743
DomainDynein_heavy_dom-2

DNHD1 DYNC1H1 DNAH11

1.36e-0514643IPR013602
DomainDHC_N2

DNHD1 DYNC1H1 DNAH11

1.36e-0514643PF08393
DomainMT

DNHD1 DYNC1H1 DNAH11

1.36e-0514643PF12777
DomainDHC_fam

DNHD1 DYNC1H1 DNAH11

1.70e-0515643IPR026983
DomainDynein_heavy_dom

DNHD1 DYNC1H1 DNAH11

1.70e-0515643IPR004273
DomainDynein_heavy

DNHD1 DYNC1H1 DNAH11

1.70e-0515643PF03028
DomainNUT

NUTM2B NUTM2A

1.15e-045642IPR024310
DomainNUT_N

NUTM2B NUTM2A

1.15e-045642IPR024309
DomainNUT

NUTM2B NUTM2A

1.15e-045642PF12881
DomainDHC_N1

DYNC1H1 DNAH11

3.19e-048642PF08385
DomainDynein_heavy_dom-1

DYNC1H1 DNAH11

3.19e-048642IPR013594
DomainDynein_heavy_chain_D4_dom

DYNC1H1 DNAH11

1.02e-0314642IPR024317
DomainAAA_8

DYNC1H1 DNAH11

1.02e-0314642PF12780
DomainATPase_dyneun-rel_AAA

DYNC1H1 DNAH11

1.02e-0314642IPR011704
DomainAAA_5

DYNC1H1 DNAH11

1.02e-0314642PF07728
DomainPBD

CDC42BPG CDC42EP1

1.52e-0317642PF00786
DomainCRIB

CDC42BPG CDC42EP1

2.11e-0320642PS50108
DomainCRIB_dom

CDC42BPG CDC42EP1

2.33e-0321642IPR000095
DomainWD40_repeat_dom

BCAS3 SEC31A LRBA HPS5 ARHGEF17

3.49e-03297645IPR017986
Domain-

BCAS3 SEC31A LRBA HPS5 ARHGEF17

5.64e-033336452.130.10.10
DomainWD40/YVTN_repeat-like_dom

BCAS3 SEC31A LRBA HPS5 ARHGEF17

5.79e-03335645IPR015943
DomainAnk

EHMT2 ANKIB1 BCL3 TP53BP2

7.76e-03228644PF00023
DomainC2

SYTL1 FER1L5 RASAL1

1.03e-02131643PF00168
Domain-

EHMT2 ANKIB1 BCL3 TP53BP2

1.03e-022486441.25.40.20
PathwayREACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION

RPN1 UGGT1 DOLK DHDDS PPP6R1 SEC31A DYNC1H1

9.71e-05307507M894
PathwayREACTOME_SYNTHESIS_OF_DOLICHYL_PHOSPHATE

DOLK DHDDS

1.83e-046502M27373
PathwayREACTOME_SYNTHESIS_OF_DOLICHYL_PHOSPHATE

DOLK DHDDS

1.83e-046502MM15119
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

KPNA5 ERCC2 GCAT UGGT1 VPS13A TTC27 SDF4 PPP6R1 STK11IP CDC42EP1

2.81e-07606681036538041
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

ERCC2 EPPK1 EHMT2 RAB3GAP2 SDF4 SEC31A TP53RK LRBA ZC3H7B DYNC1H1

1.09e-06704681029955894
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ERCC2 EPPK1 SLC45A3 BCAS3 SDF4 PPP6R1 LRBA ZC3H7B STK11IP DENND1A DYNC1H1 RASAL1

1.41e-061105681235748872
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CDC42BPG FREM2 SGSM1 RPN1 VPS13A PPP6R1 BCL3 GAL3ST2 ARHGEF17 DYNC1H1

1.63e-06736681029676528
Pubmed

Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption.

DYNC1H1 DNAH11

1.13e-05368222887640
Pubmed

The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.

NUTM2B NUTM2A

1.13e-05368222456610
Pubmed

Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.

HAAO RXFP3

1.13e-05368220211485
Pubmed

TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

TRPM5 TLR4

1.13e-05368232521253
Pubmed

The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.

NUTM2E NUTM2B

1.13e-05368226542179
Pubmed

Two populations of node monocilia initiate left-right asymmetry in the mouse.

TMEM163 DNAH11

2.25e-05468212859898
Pubmed

TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration.

SPON1 TLR4

3.75e-05568227091427
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

KPNA5 EPPK1 RPN1 RAB3GAP2 UGGT1 TTC27 LRBA DYNC1H1

3.80e-0564768826618866
Pubmed

RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

TMEM163 DNAH11

7.86e-05768222233545
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

DDX20 PPP6R1 TP53RK LRBA ZC3H7B

1.14e-0424268534011540
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

KPNA5 ERCC2 GCAT RPN1 UGGT1 TTC27 SDF4 DDX20 DYNC1H1 CDC42EP1

1.59e-041257681037317656
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

EHMT2 RAB3GAP2 TTC27 PPP6R1 LRBA TP53BP2

1.70e-0441868634709266
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CCDC22 UGGT1 VPS13A TTC27 SDF4 PPP6R1 CTDSPL TP53BP2 CDC42EP1

1.99e-04104968927880917
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ERCC2 EPPK1 GCAT RPN1 UGGT1 SDF4 SEC31A ARHGEF17 STK11IP DYNC1H1

2.04e-041297681033545068
Pubmed

Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.

RPN1 SDF4

2.05e-04116828938438
Pubmed

Global landscape of HIV-human protein complexes.

EPPK1 RPN1 UGGT1 SDF4 DDX20 DYNC1H1

2.74e-0445768622190034
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

DNHD1 RPN1 RAB3GAP2 UGGT1 DDX20 PPP6R1 DYNC1H1

3.34e-0467068722990118
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DYNC1H1 DNAH11

3.38e-04146829373155
Pubmed

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

RPN1 UGGT1 SDF4 CDC42EP1

3.84e-0417468432149426
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

ERCC2 GCAT DOLK SDF4 DDX20 STK11IP DYNC1H1

3.85e-0468668728380382
Pubmed

Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.

WNT8A TMEM163

4.44e-041668221362415
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

RPN1 TTC27 DDX20 PPP6R1

4.64e-0418368423956138
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CCDC22 RPN1 UGGT1 TTC27 SDF4 DDX20 PPP6R1 BCL3 DENND1A DYNC1H1

4.68e-041440681030833792
Pubmed

Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.

RPN1 UGGT1

5.03e-041768232938586
Pubmed

Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.

CILK1 TMEM163

5.65e-041868234893605
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDC42BPG SGSM1 BCAS3 ANKIB1 CILK1 LRBA SYTL1 HPS5 CTDSPL DENND1A

6.07e-041489681028611215
Pubmed

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.

EHMT2 DYNC1H1

7.00e-042068236551904
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CCDC22 RPN1 RAB3GAP2 LRBA DYNC1H1 TP53BP2

7.20e-0454968638280479
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 EPPK1 RPN1 VPS13A

7.50e-0420868433230847
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

CCDC22 RPN1 INPP5B UGGT1 SDF4 SEC31A LRBA CDC42EP1

7.64e-04100768834597346
Pubmed

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

BLK BCAS3 NLRP8

7.68e-049168322610502
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

RPN1 TTC27 DDX20 DYNC1H1

7.91e-0421168417314511
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

EHMT2 INPP5B VPS13A SEC31A LRBA DYNC1H1 CDC42EP1

8.04e-0477768735844135
Pubmed

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

ERCC2 DYNC1H1

8.48e-042268210932192
Pubmed

FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development.

TTC27 PCDH12

9.28e-042368226124079
Pubmed

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

DDX20 SEC31A

9.28e-042368220696395
Pubmed

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

NTSR2 HAAO

9.28e-042368220468071
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

VPS13A CILK1 HPS5

1.07e-0310268310231032
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

DOLK VPS13A ANKIB1 TTC27 SDF4 SEC31A LRBA STK11IP

1.07e-03106168833845483
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DOLK PPP6R1 ZC3H7B

1.13e-0310468310470851
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CCDC22 RPN1 ANKIB1 TTC27 DDX20 SEC31A TP53RK DYNC1H1 TP53BP2

1.24e-03135368929467282
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ERCC2 EHMT2 GCAT FBF1 TTC27 SDF4 PPP6R1 CDC42EP1

1.47e-03111668831753913
Pubmed

Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein.

RPN1 UGGT1

1.69e-033168237939376
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

PPP6R1 DYNC1H1

1.69e-033168228089446
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

CDC42BPG FREM2 ANKIB1 PPP6R1 ZC3H7B HPS5

1.71e-0365068638777146
Pubmed

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.

DDX20 PPP6R1 GAL3ST2

1.75e-0312168331900314
Pubmed

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

ERCC2 TRPM5 TLR4 SDF4

1.78e-0326368419773279
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

FBF1 PPP6R1 DENND1A TP53BP2 CDC42EP1

1.82e-0344668524255178
Cytoband10q23.2

NUTM2A NUTM2D

2.90e-041768210q23.2
Cytoband4q31.3

FHDC1 LRBA

9.78e-04316824q31.3
Cytoband10q22.3

NUTM2E NUTM2B

1.88e-034368210q22.3
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM5 UGGT1 FHDC1 ARHGEF17 CTDSPL

1.13e-05195675bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGGT1 VPS13A TMEM163 SEC31A DYNC1H1

1.13e-051956753e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGGT1 VPS13A TMEM163 SEC31A DYNC1H1

1.13e-051956757796ea9247f4c63762f0de8490fed08b9717fa23
DiseaseEndometrial Stromal Sarcoma

NUTM2B NUTM2A

4.91e-055662C0206630
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

7.35e-056662C0334488
DiseaseDyslipidemias

BCL3 DNAH11

1.32e-0324662C0242339
DiseaseDyslipoproteinemias

BCL3 DNAH11

1.32e-0324662C0598784
Diseasemyeloperoxidase measurement

RPN1 BCAS3

1.55e-0326662EFO_0005243
Diseasemacular degeneration (is_implicated_in)

ERCC2 TLR4

1.67e-0327662DOID:4448 (is_implicated_in)
Diseaseproteinuria (implicated_via_orthology)

TMEM163 HPS5

2.06e-0330662DOID:576 (implicated_via_orthology)
Diseaselifestyle measurement, alcohol consumption measurement

TTC27 LRBA DENND1A

2.21e-03115663EFO_0007878, EFO_0010724

Protein segments in the cluster

PeptideGeneStartEntry
PADLLLTEEEFLSFL

SDF4

211

Q9BRK5
LSLAPDDSLLVLAGT

HAAO

246

P46952
SSLPLVTGEFLELDL

BPIFB4

366

P59827
DDLLLRLSAAEGSFL

DNAH11

3651

Q96DT5
PRAALSSSELLELGD

ANKIB1

906

Q9P2G1
TSSLETERGFEELPL

EHMT2

411

Q96KQ7
VLLAEPADFESLLLS

DDX20

56

Q9UHI6
LADFTTSLLGRPLDE

DNHD1

4056

Q96M86
LLFLAERLPTDASED

CCDC22

101

O60826
PLLDFDTDDLDLNSL

BCAS3

776

Q9H6U6
PLALLLDSSLEGEFD

TP53BP2

926

Q13625
LVLDATFDDLVPLAL

ABHD16B

266

Q9H3Z7
SRLLFSSDPDVLADV

KPNA5

261

O15131
TASPLALLEELTLGD

RASAL1

286

O95294
AALSDSRLLLFDAPD

CDC42BPG

971

Q6DT37
LEEELSSLLDPSTGL

PCDH12

1031

Q9NPG4
FTRGSLEDLLSVDPE

ARHGEF17

1721

Q96PE2
TPFSDNDLALLLRLD

RAB3GAP2

661

Q9H2M9
LSLGPSADRELLTFL

FHDC1

541

Q9C0D6
PETEGLETALLFLFS

OR10D4P

16

Q8NGN7
FLSLFLDERDSGPLI

DOLK

391

Q9UPQ8
PSRLELLSEEGLLSF

NTSR2

251

O95665
LLLLLDGFEELTSTL

NLRP8

281

Q86W28
SDDSLLLFVLESPFL

FREM2

591

Q5SZK8
AEFESLDPLLSALRL

HPS5

16

Q9UPZ3
EFLSFLLSPLELSDS

ECE2

391

P0DPD6
SRLPLSDDLLESLLS

EFHC2

666

Q5JST6
EELDLTLPTNFRDLS

LRBA

2256

P50851
LEITDLADFSPLTLL

ERCC2

386

P18074
LFEALLTPEDAVLSD

GCAT

141

O75600
LLAGFLHSDLELDTP

GAL3ST2

26

Q9H3Q3
FSSEDLEDPLRGLLS

FBF1

141

Q8TES7
TDTELLDLIPFFEGL

CTDSPL

246

O15194
LDFLKTDEGSRLSLP

BLK

321

P51451
LLSTLGEFLEDHFPL

CENPK

176

Q9BS16
DSLLSFRLDLDLGPS

CDC42EP1

191

Q00587
FRLDLDLGPSLLSEL

CDC42EP1

196

Q00587
GTSSDALLALLDPLS

DENND1A

776

Q8TEH3
SVAEALLLFLESLPE

INPP5B

881

P32019
AEDIPLLFSLLSDVF

DYNC1H1

2151

Q14204
LRALLDSAAPGTLDL

BCL3

221

P20749
GLLDPSDISESLLDK

DHDDS

176

Q86SQ9
LFLDGSLELLESFSA

SERPINA6

131

P08185
GSSEEEELPSLAFLL

NUTM2A

751

Q8IVF1
GSSEEEELPSLAFLL

NUTM2B

751

A6NNL0
SEEEELPSLAFLLGS

NUTM2D

681

Q5VT03
GSSEEEELPSLAFLL

NUTM2E

751

B1AL46
LAELFSLVPDLLEAA

RXFP3

21

Q9NSD7
PETEGLLDLSFLTEE

SYTL1

26

Q8IYJ3
LLTPSTLFLLDEDAA

STK11IP

966

Q8N1F8
LPLAAALAFSDETLD

SPON1

21

Q9HCB6
FSPDDFLGVLELDLS

FER1L5

1826

A0AVI2
RATLDPETGLLFLSL

EPPK1

5071

P58107
ATSFLLALEPELEAR

RPN1

66

P04843
VTEFVLLGLSDDPDL

OR6C3

6

Q9NZP0
TPLEALLSDLFRDPD

SLC45A3

141

Q96JT2
LDDLDFSPSLSRIDL

CILK1

421

Q9UPZ9
DGIFSPTSNLLLLDL

VPS13A

661

Q96RL7
TFSEEAPLRTGLEDL

TRPM5

666

Q9NZQ8
ELLSSSDKAAGLDLP

nan

16

Q6ZSR6
APLLVILDDEALAFS

SGSM1

986

Q2NKQ1
SHLDTLLEREDLSLP

PPP6R1

11

Q9UPN7
LIDFGLSFISALPED

TP53RK

181

Q96S44
FLPSAEAELIFLEES

WNT8A

241

Q9H1J5
ASLEIFELDLSDPSL

SEC31A

41

O94979
LDAFVLSLLTLDGES

TTC27

136

Q6P3X3
AFSEVDLPSLEFLDL

TLR4

366

O00206
DLSTRLLPEVDDFLF

TMEM163

176

Q8TC26
FSTPLLLEASEFLAE

UGGT1

56

Q9NYU2
FGPELDTLLDSLSLV

ZC3H7B

261

Q9UGR2