Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal circulating fibrinogen level	YOD1 LPA PLG	6.33e-06	8	69	3	MP:0010213
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	2.40e-05	2	69	2	MP:0009507
MousePheno	esophageal ulcer	LPA PLG	2.40e-05	2	69	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	2.40e-05	2	69	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	2.40e-05	2	69	2	MP:0005035
MousePheno	ectropion	LPA PLG	2.40e-05	2	69	2	MP:0006164
MousePheno	absent cornea epithelium	LPA PLG	7.18e-05	3	69	2	MP:0020856
MousePheno	increased circulating fibrinogen level	LPA PLG	1.43e-04	4	69	2	MP:0012331
MousePheno	proctitis	LPA PLG	1.43e-04	4	69	2	MP:0003305
MousePheno	abnormal acute phase protein level	YOD1 LPA PLG	2.45e-04	25	69	3	MP:0010211
MousePheno	gastric ulcer	LPA PLG	3.56e-04	6	69	2	MP:0003282
Domain	Kringle	LPA MST1L PLG	5.70e-05	17	84	3	IPR000001
Domain	Kringle_CS	LPA MST1L PLG	5.70e-05	17	84	3	IPR018056
Domain	KRINGLE_2	LPA MST1L PLG	5.70e-05	17	84	3	PS50070
Domain	Kringle	LPA MST1L PLG	5.70e-05	17	84	3	PF00051
Domain	KRINGLE_1	LPA MST1L PLG	5.70e-05	17	84	3	PS00021
Domain	KR	LPA MST1L PLG	5.70e-05	17	84	3	SM00130
Domain	Lipin_N	LPIN3 LPIN2	5.98e-05	3	84	2	IPR007651
Domain	Lipin_mid	LPIN3 LPIN2	5.98e-05	3	84	2	PF16876
Domain	Lipin_mid	LPIN3 LPIN2	5.98e-05	3	84	2	IPR031703
Domain	Lipin_N	LPIN3 LPIN2	5.98e-05	3	84	2	PF04571
Domain	PAN_AP	MST1L PLG	1.98e-04	5	84	2	SM00473
Domain	LNS2	LPIN3 LPIN2	2.96e-04	6	84	2	PF08235
Domain	LNS2	LPIN3 LPIN2	2.96e-04	6	84	2	IPR013209
Domain	LNS2	LPIN3 LPIN2	2.96e-04	6	84	2	SM00775
Domain	LNS2/PITP	LPIN3 LPIN2	2.96e-04	6	84	2	IPR031315
Domain	Kringle-like	LPA MST1L PLG	3.96e-04	32	84	3	IPR013806
Domain	PAN	MST1L PLG	4.14e-04	7	84	2	PS50948
Domain	Pan_app	MST1L PLG	4.14e-04	7	84	2	IPR003609
Domain	PAN_1	MST1L PLG	4.14e-04	7	84	2	PF00024
Domain	-	MGAM TMEM190	1.07e-03	11	84	2	4.10.110.10
Domain	P_trefoil_dom	MGAM TMEM190	1.28e-03	12	84	2	IPR000519
Domain	Peptidase_S1A	LPA MST1L PLG TMPRSS11B	1.69e-03	113	84	4	IPR001314
Domain	TRYPSIN_DOM	LPA MST1L PLG TMPRSS11B	1.80e-03	115	84	4	PS50240
Domain	Tryp_SPc	LPA MST1L PLG TMPRSS11B	1.92e-03	117	84	4	SM00020
Domain	Trypsin	LPA MST1L PLG TMPRSS11B	2.17e-03	121	84	4	PF00089
Domain	Trypsin_dom	LPA MST1L PLG TMPRSS11B	2.17e-03	121	84	4	IPR001254
Domain	Peptidase_S1_PA	LPA MST1L PLG TMPRSS11B	2.30e-03	123	84	4	IPR009003
Domain	aa-tRNA-synth_I_CS	VARS1 YARS2	2.92e-03	18	84	2	IPR001412
Domain	AA_TRNA_LIGASE_I	VARS1 YARS2	3.25e-03	19	84	2	PS00178
Domain	GST_N	GSTO2 VARS1	4.36e-03	22	84	2	PF02798
Pathway	KEGG_GALACTOSE_METABOLISM	MGAM GLA GALT PFKL	6.83e-06	26	68	4	M4377
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 TANC2 LPIN3 MTOR RTTN TMC6 SEC16A PER1 CUL9 TANC1 FUT1 EDC4 ESPL1	4.71e-06	1105	89	13	35748872
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	6.48e-06	2	89	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	6.48e-06	2	89	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	6.48e-06	2	89	2	38328826
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	9819364
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	6.48e-06	2	89	2	23943648
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	6.48e-06	2	89	2	12083480
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	6.48e-06	2	89	2	18420257
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	6.48e-06	2	89	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	6.48e-06	2	89	2	23041318
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	6.48e-06	2	89	2	18566672
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	6.48e-06	2	89	2	19752236
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	6.48e-06	2	89	2	6216475
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	6.48e-06	2	89	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	6.48e-06	2	89	2	12428098
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	6.48e-06	2	89	2	20440070
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	6.48e-06	2	89	2	24732409
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	6.48e-06	2	89	2	15456492
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	6.48e-06	2	89	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	6.48e-06	2	89	2	24574269
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	16956791
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	6.48e-06	2	89	2	25409527
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	6.48e-06	2	89	2	1543918
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	6.48e-06	2	89	2	8704243
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	6.48e-06	2	89	2	17267741
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	6.48e-06	2	89	2	23702659
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	6.48e-06	2	89	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	6.48e-06	2	89	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	6.48e-06	2	89	2	23456978
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	6.48e-06	2	89	2	10854210
Pubmed	Gender affects skin wound healing in plasminogen deficient mice.	LPA PLG	6.48e-06	2	89	2	23527289
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	6.48e-06	2	89	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	6.48e-06	2	89	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	6.48e-06	2	89	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	6.48e-06	2	89	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	6.48e-06	2	89	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	6.48e-06	2	89	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	6.48e-06	2	89	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	6.48e-06	2	89	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	6.48e-06	2	89	2	12225871
Pubmed	Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.	LPA PLG	6.48e-06	2	89	2	9770530
Pubmed	Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.	LPA LRP2	6.48e-06	2	89	2	10073957
Pubmed	Plasminogen activation is required for the development of radiation-induced dermatitis.	LPA PLG	6.48e-06	2	89	2	30323258
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	6.48e-06	2	89	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	6.48e-06	2	89	2	9884337
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	6.48e-06	2	89	2	26473342
Pubmed	Nonfibrinolytic functions of plasminogen.	LPA PLG	6.48e-06	2	89	2	10816371
Pubmed	Plasminogen is a critical regulator of cutaneous wound healing.	LPA PLG	6.48e-06	2	89	2	26791370
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	6.48e-06	2	89	2	32694536
Pubmed	Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.	LPA PLG	6.48e-06	2	89	2	7525077
Pubmed	Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.	LPA PLG	6.48e-06	2	89	2	16052596
Pubmed	Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	17122079
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	6.48e-06	2	89	2	16103174
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	6.48e-06	2	89	2	21300353
Pubmed	Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.	LPA PLG	6.48e-06	2	89	2	15737740
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	6.48e-06	2	89	2	11306011
Pubmed	Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.	LPA PLG	6.48e-06	2	89	2	12149246
Pubmed	Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.	LPA PLG	6.48e-06	2	89	2	22056679
Pubmed	Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.	LPA PLG	6.48e-06	2	89	2	18311818
Pubmed	Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.	LPA PLG	6.48e-06	2	89	2	21190118
Pubmed	The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.	LPA PLG	6.48e-06	2	89	2	18039665
Pubmed	Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	9671388
Pubmed	A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.	LPA PLG	6.48e-06	2	89	2	18997104
Pubmed	Growth and behavioral development in plasminogen gene-targeted mice.	LPA PLG	6.48e-06	2	89	2	10885855
Pubmed	Cellular density regulation of plasminogen gene expression in mouse hepatocytes.	LPA PLG	6.48e-06	2	89	2	12559391
Pubmed	Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.	LPA PLG	6.48e-06	2	89	2	27319402
Pubmed	Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.	LPA PLG	6.48e-06	2	89	2	15333838
Pubmed	Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.	LPA PLG	6.48e-06	2	89	2	16150044
Pubmed	Plasminogen has a broad extrahepatic distribution.	LPA PLG	6.48e-06	2	89	2	11916082
Pubmed	Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.	TANC2 TANC1	6.48e-06	2	89	2	21068316
Pubmed	Unaltered prion protein cleavage in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	16543819
Pubmed	Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.	LPA PLG	6.48e-06	2	89	2	34423816
Pubmed	Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	11500461
Pubmed	Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.	LPA PLG	6.48e-06	2	89	2	12167431
Pubmed	Impaired wound healing in mice with a disrupted plasminogen gene.	LPA PLG	6.48e-06	2	89	2	8612226
Pubmed	Role of plasminogen activation in neuronal organization and survival.	LPA PLG	6.48e-06	2	89	2	19683575
Pubmed	Ovulation in plasminogen-deficient mice.	LPA PLG	6.48e-06	2	89	2	10537128
Pubmed	Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.	LPA PLG	6.48e-06	2	89	2	23555246
Pubmed	Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.	LPA PLG	6.48e-06	2	89	2	18685433
Pubmed	Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.	LPA PLG	6.48e-06	2	89	2	31462325
Pubmed	Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.	LPA PLG	6.48e-06	2	89	2	9242524
Pubmed	Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.	LPA PLG	1.94e-05	3	89	2	16818777
Pubmed	Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.	LPIN3 LPIN2	1.94e-05	3	89	2	10884287
Pubmed	Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.	LPA PLG	1.94e-05	3	89	2	19273908
Pubmed	Lactational competence and involution of the mouse mammary gland require plasminogen.	LPA PLG	1.94e-05	3	89	2	11003846
Pubmed	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.	LPIN3 LPIN2	1.94e-05	3	89	2	18694939
Pubmed	Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1.	LPA PLG	1.94e-05	3	89	2	28320709
Pubmed	Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.	LPA PLG	1.94e-05	3	89	2	12431907
Pubmed	Potentiation of TLR4 signalling by plasmin activity.	LPA PLG	1.94e-05	3	89	2	16413499
Pubmed	Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.	LPA PLG	1.94e-05	3	89	2	33827130
Pubmed	Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.	LPA PLG	1.94e-05	3	89	2	24612416
Pubmed	Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.	LPIN3 LPIN2	1.94e-05	3	89	2	30507612
Pubmed	In vivo regulation of plasminogen function by plasma carboxypeptidase B.	LPA PLG	1.94e-05	3	89	2	12417566
Pubmed	Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.	LPIN3 LPIN2	1.94e-05	3	89	2	33596934
Pubmed	Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.	LPA PLG	1.94e-05	3	89	2	19465692
Pubmed	Lipin proteins form homo- and hetero-oligomers.	LPIN3 LPIN2	1.94e-05	3	89	2	20735359
Pubmed	Alpha2-antiplasmin plays a significant role in acute pulmonary embolism.	LPA PLG	1.94e-05	3	89	2	12911586
Pubmed	Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.	LPA PLG	1.94e-05	3	89	2	31316511
Cytoband	Ensembl 112 genes in cytogenetic band chr6q26	LPA PLG	4.38e-04	16	89	2	chr6q26
Cytoband	6p21.1	UBR2 TSPO2 CUL9	5.19e-04	80	89	3	6p21.1
Cytoband	6q26	LPA PLG	5.57e-04	18	89	2	6q26
GeneFamily	Lipins	LPIN3 LPIN2	2.15e-05	3	49	2	1043
GeneFamily	Aminoacyl tRNA synthetases, Class I	VARS1 YARS2	1.19e-03	19	49	2	131
Drug	Kinsei	MGAM TNFSF14 RNF112	1.03e-06	6	86	3	CID000071376
Drug	m189	MGAM GLA MTOR CAT PFKL POLG2 MMD	5.07e-06	178	86	7	CID000022230
Drug	TAK-013	MGAM GLA GNRH2	6.13e-06	10	86	3	CID003038517
Drug	trandolapril	ADRB1 ACHE CAT	8.40e-06	11	86	3	ctd:C052035
Drug	1-Behenyl-2-lauryl-sn-glycero-3-phosphocholine	MTOR LPA	1.41e-05	2	86	2	CID000129220
Drug	1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide	ACHE CAT	1.41e-05	2	86	2	ctd:C515196
Drug	NSC299933	MGAM AMPD2 ACHE	1.45e-05	13	86	3	CID000431902
Drug	JC-1 dye	ADRB1 MTOR CAT GRIN2C TAFAZZIN	1.77e-05	85	86	5	CID000003801
Drug	solanine	TNFSF14 ACHE CAT	1.84e-05	14	86	3	CID000030185
Drug	phosalone	TNFSF14 MTOR ACHE	2.29e-05	15	86	3	CID000004793
Drug	aspartate	MGAM AMPD2 CAT GRIN2C PFKL SLC25A25 PLOD1 GNRH2 TAFAZZIN YARS2	2.57e-05	518	86	10	CID000000424
Drug	Aminocaproic Acid	LPA PLG	4.22e-05	3	86	2	DB00513
Drug	Temefos	ACHE CAT	4.22e-05	3	86	2	ctd:D000002
Drug	jionoside D	ACHE CAT	4.22e-05	3	86	2	CID009895632
Drug	Tocotrienols	ACHE CAT	4.22e-05	3	86	2	ctd:D024508
Drug	Tetraethyl Lead	ACHE PLG	4.22e-05	3	86	2	ctd:D013756
Drug	3-dimethylaminophenol	ACHE CAT	4.22e-05	3	86	2	CID000007421
Drug	chong-myung-tang	ACHE CAT	4.22e-05	3	86	2	ctd:C555710
Drug	D-raffinose	LDHD MGAM GLA LPA CAT	6.40e-05	111	86	5	CID000010542
Drug	AC1L1KF5	ADRB1 GLA SULT2A1 LPA GNRH2	6.97e-05	113	86	5	CID000005470
Drug	3-phosphoglycerate	LDHD MGAM GLA PFKL PLG	7.26e-05	114	86	5	CID000000724
Drug	D-arabinitol	MGAM GLA GALT CAT FUT1	7.26e-05	114	86	5	CID000000827
Drug	selenate	MGAM CAT FUT1 MMD	7.87e-05	60	86	4	CID000001089
Drug	DBNPA	MGAM CAT	8.42e-05	4	86	2	CID000025059
Drug	3,5-di-tert-butyl-4-hydroxybenzaldehyde	CAT MMD	8.42e-05	4	86	2	CID000073219
Drug	3,5-dinitrotyrosine	MGAM CAT	8.42e-05	4	86	2	CID000065265
Drug	CuATP	MGAM GNRH2	8.42e-05	4	86	2	CID000167769
Drug	Piracetam	ACHE CAT	8.42e-05	4	86	2	ctd:D010889
Drug	sodium oxide (Na2O	MGAM MTOR	8.42e-05	4	86	2	CID000073971
Drug	dichlorfop-methyl	ACHE CAT	8.42e-05	4	86	2	ctd:C012891
Drug	AC1Q6CTU	MTOR ACHE WIF1 CAT PLOD1	8.56e-05	118	86	5	CID000021362
Drug	D-G-G	MGAM RNF112 GRIN2C	8.72e-05	23	86	3	CID000444866
Drug	NaOH	MGAM GLA CAT MMD	8.96e-05	62	86	4	CID000014798
Drug	chlorin	MGAM CAT PLOD1	9.94e-05	24	86	3	CID000065106
Drug	cilengitide	MGAM GLA MTOR	9.94e-05	24	86	3	CID000176873
Drug	alpha-ketobutyrate	MPST LDHD CAT VARS1	1.01e-04	64	86	4	CID000000058
Drug	DL-tryptophan	RNF112 CAT TNFRSF18 PFKL YARS2	1.17e-04	126	86	5	CID000001148
Drug	stevioside	MTOR ACHE CAT	1.27e-04	26	86	3	ctd:C012043
Drug	KIN-844	ACHE CAT	1.40e-04	5	86	2	CID000206006
Drug	AC1LAW6Y	MGAM GLA	1.40e-04	5	86	2	CID000521877
Drug	NSC291853	MTOR CAT	1.40e-04	5	86	2	CID005358946
Drug	Desmodium gangeticum extract	ACHE CAT	1.40e-04	5	86	2	ctd:C521776
Drug	EDTA-chromium	MGAM LPA	1.40e-04	5	86	2	CID000028282
Drug	acetylarsenocholine	MGAM ACHE	1.40e-04	5	86	2	CID000162399
Drug	propetamphos	ACHE CAT	1.40e-04	5	86	2	ctd:C035967
Drug	beta-D-glucopyranosyl azide	MGAM GLA	1.40e-04	5	86	2	CID000152302
Drug	1,2-epoxy-4-vinylcyclohexane	ACHE CAT	1.40e-04	5	86	2	ctd:C118009
Drug	dechlorane plus	SULT2A1 ACHE CAT	1.43e-04	27	86	3	ctd:C526360
Drug	creatinine	PIGN TGM4 MGAM GLA LPA CAT MMD	1.48e-04	302	86	7	CID000000588
Drug	inulin	MGAM GCNT3 ODF4 LPA CAT	1.50e-04	133	86	5	CID000024763
Disease	Premature atrial contractions	LDHD ADRB1 DPP10 GCNT3	1.78e-05	55	83	4	HP_0006699
Disease	myoglobinuria (implicated_via_orthology)	LPIN3 LPIN2	2.34e-05	3	83	2	DOID:0080108 (implicated_via_orthology)
Disease	chronic kidney disease, APOL1 risk genotype carrier status	LPA PLG	7.77e-05	5	83	2	EFO_0003884, EFO_0009324
Disease	plasma plasminogen measurement	LPA PLG	7.77e-05	5	83	2	EFO_0006309
Disease	angiostatin measurement	LPA PLG	1.16e-04	6	83	2	EFO_0008024
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	1.63e-04	7	83	2	EFO_0004614, EFO_0006925
Disease	familial Mediterranean fever (is_marker_for)	LPA CAT	2.78e-04	9	83	2	DOID:2987 (is_marker_for)
Disease	developmental disorder of mental health (implicated_via_orthology)	TANC2 TANC1 GRIN2C	3.60e-04	49	83	3	DOID:0060037 (implicated_via_orthology)
Disease	Reactive Hyperemia	ADRB1 CAT	5.98e-04	13	83	2	C0178824
Disease	Venous Engorgement	ADRB1 CAT	5.98e-04	13	83	2	C0042484
Disease	Active Hyperemia	ADRB1 CAT	5.98e-04	13	83	2	C0333233
Disease	Hyperemia	ADRB1 CAT	5.98e-04	13	83	2	C0020452
Disease	Bladder Neoplasm	MTOR ACHE GSTO2 ESPL1	6.67e-04	140	83	4	C0005695
Disease	Malignant neoplasm of urinary bladder	MTOR ACHE GSTO2 ESPL1	6.85e-04	141	83	4	C0005684
Disease	lipid metabolism disorder (implicated_via_orthology)	LPIN3 LPIN2	8.02e-04	15	83	2	DOID:3146 (implicated_via_orthology)
Disease	platelet crit	TYK2 LPIN3 ADRB1 TBC1D10A LPA RTTN TMC6 RPRD2 PLOD1	1.42e-03	952	83	9	EFO_0007985
Disease	Deep Vein Thrombosis	LPA PLG	1.59e-03	21	83	2	C0149871
Disease	Venous Thrombosis	LPA PLG	1.59e-03	21	83	2	C0042487
Disease	Hypertensive disease	ADRB1 MTOR CAT PLG	2.06e-03	190	83	4	C0020538

Protein segments in the cluster

Peptide	Gene	Start	Entry
FEHRASTLSWPLWMG	ACHE	461	P22303
SALVSFLPILMHWWR	ADRB1	186	P08588
FLPILMHWWRAESDE	ADRB1	191	P08588
ENHWKGRARWLMPVI	C8orf44	31	Q96CB5
MVWDFWSLRPESLHQ	CAT	181	P04040
LARTPTMGWLHWERF	GLA	36	P06280
RWAVMHRVHSPNVRW	AMPD2	556	Q01433
SRHPGMRKWPRQYEW	CREG2	241	Q8IUH2
AHWWSPDGERLAFLM	DPP10	241	Q8N608
HWLREFLGHWEAMPE	RAET1E	191	Q8TD07
THTWPRALAVLMGLW	RBAKDN	26	A6NC62
VWDLDMLRSSHSTWP	EDC4	266	Q6P2E9
IRLWHRGAMVIQATW	IQCN	946	Q9H0B3
LPFQWRITHSFRWMA	ODF4	66	Q2M2E3
AWPVGSRTDTMWRLR	YOD1	36	Q5VVQ6
AWMRVHSWASRLFAP	CDRT15	166	Q96T59
SPLRAESHMQWAWGR	LPIN3	236	Q9BQK8
GPLAHTVEDFWRMIW	PTPRE	501	P23469
AGWDHRIRVFHWRTM	GNB1L	271	Q9BYB4
LGRHALMSGTRAWKW	MST1L	391	Q2TV78
FVGRRMPLWCWSHSN	MTMR10	276	Q9NXD2
LEWHTWGMFSRDQPP	MGAM	1146	O43451
TMDTSWAGFVHPWSR	PER1	436	O15534
FEHRMPREQWWLSLR	PFKL	731	P17858
KWMHFQRWGLPRRVE	FAM205A	301	Q6ZU69
KWMHFQRWGLPRRVE	FAM205BP	31	Q63HN1
HTPALRLWISAMKWD	GSTO2	196	Q9H4Y5
LRHRLQWWRKFAMSP	POLG2	256	Q9UHN1
PRMNEHLLFWSDWGH	LRP2	1561	P98164
LLLRSVDEFWWFPHM	NDST4	366	Q9H3R1
WWRGMLVRRTLLHAA	IQCF5	21	A8MTL0
HWPLDASFRAVLEMW	SMPD4	426	Q9NXE4
LGPLASHMRWFIWLM	MMD	121	Q15546
PLMTRHGRLWSNFWG	PLOD1	406	Q02809
SMWTARGPFRRDRWS	PTPN20	81	Q4JDL3
WWTGRLALDHRMEVL	ESPL1	1776	Q14674
ESGRMWSWNKLFPIH	PRMT7	186	Q9NVM4
VRSSMVRAAWPHFSW	FAM151A	246	Q8WW52
WVLVSAHRMKRPWQG	GALT	41	P07902
MARLLRSATWELFPW	LDHD	1	Q86WU2
MRGEEWFILQHCPTW	FSCN3	251	Q9NQT6
HLWATLQRARWMPGS	GCNT3	331	O95395
SWSSMTPHWHRRIPL	LPA	1411	P08519
MGPHRRLQWTWLGRA	CUL9	1746	Q8IWT3
REWWHRTIQRPVTMG	HLTF	611	Q14527
MPWEGRTTAQWSLHR	GNRH2	81	O43555
HWMKWLRRSAYPHRL	RPRD2	61	Q5VT52
LIRVAILWHEMWHEG	MTOR	2016	P42345
ATCMPAWKHEWLERR	MAP3K1	191	Q13233
DSRTPWRELQLHDWM	FUT1	136	P19526
EMSCRHWARWLTPVI	C8orf17	61	Q9NRJ1
WMSLWFLPLGSHSEE	RTTN	1346	Q86VV8
RWHRMRGETTLWNPG	VARS1	366	P26640
PRVWWMFRAFGHHAV	MPST	111	P25325
KRGEHLSWLGIFWMT	SV2B	231	Q7L1I2
HPTFLWLKWRVSRVM	TAS2R3	116	Q9NYW6
MAAPILRSFSWGRWS	YARS2	1	Q9Y2Z4
WHRLIPLTWACMARQ	MTERF4	11	Q7Z6M4
FERGTLSAPRLWSWM	PRORY	141	Q9H606
MHRARWLTPVIPALW	NANOGNB	1	Q7Z5D8
MFCHPSFREWLVWRA	TANC1	811	Q9C0D5
MFVHPSFREWLIWRE	TANC2	761	Q9HCD6
FHVWTDAWMKRPDLP	TGM4	326	P49221
GSWFDHIHGWMPMRE	SULT2A1	161	Q06520
SWPWQVSLRTRFGMH	PLG	591	P00747
FTVEERQTGMWWRHL	SLC25A25	176	Q6KCM7
HPLFLWMKWRIDRVI	TAS2R7	116	Q9NYW3
MRRGPWERWSLASHR	ZNF565	1	Q8N9K5
FWWAKRRDVLHMPGF	TMEM190	101	Q8WZ59
MAGWWPALSRAARRH	MPV17L	1	Q2QL34
LARGIWMWSHPFLLG	RNF112	221	Q9ULX5
MYRHGISSQRSWPLW	TMPRSS11B	1	Q86T26
EKWGDWRPHLAMVLS	SEC16A	1696	O15027
HIWNLKLMRWTPAAA	TAFAZZIN	86	Q16635
WFLLQLHWRLGEMVT	TNFSF14	56	O43557
FWDMRLWHVVGIFSL	TMIE	51	Q8NEW7
KRWMGDWHSQGRLLT	TRIL	371	Q7L0X0
MARRSAFPAAALWLW	WIF1	1	Q9Y5W5
AAWPFLTRLWTRAKM	PIGN	576	O95427
FHGMLLLRGQTTWEW	ZDHHC24	216	Q6UX98
GLHIWQLRSQCMWPR	TNFRSF18	186	Q9Y5U5
PILVWLFTRDHMSGW	TSPO2	16	Q5TGU0
PRVSWLPWVHRYLME	TMC6	706	Q7Z403
WHFLHVGTMAWVRIP	LCMT2	511	O60294
ARLVAMGSAWPWLLH	GTF3C1	1801	Q12789
MGSAWPWLLHSVRLK	GTF3C1	1806	Q12789
GWHLWRSVRAGIMPF	UBR2	1501	Q8IWV8
RTLPWSSVLRVWDMF	TBC1D10A	281	Q9BXI6
AFHRLIWEVWMPFVR	TFIP11	476	Q9UBB9
DEFPGWRRRHWAVKM	TRPC4	316	Q9UBN4
ALNPRESWDMWHPTL	TRPC4	461	Q9UBN4
DVWLRRERGHVPMAW	TYK2	696	P29597
LRSESHMEWTWGGFP	LPIN2	256	Q92539
HRLWEMVGRWEHGVL	GRIN2C	366	Q14957