Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH3 domain binding	DOCK1 SHANK2 MAP4K3 CD2AP SH3KBP1 SHANK3	2.11e-06	143	53	6	GO:0017124
GeneOntologyMolecularFunction	protein domain specific binding	DOCK1 ARHGAP5 DLGAP2 DLGAP3 SHANK2 MAP4K3 CD2AP SH3KBP1 TNKS1BP1 SRRM2 SHANK3	1.51e-05	875	53	11	GO:0019904
GeneOntologyMolecularFunction	actin binding	XIRP1 PHACTR2 CD2AP UTRN PALLD SHANK3 MYO16 PHACTR1	3.55e-05	479	53	8	GO:0003779
GeneOntologyMolecularFunction	synaptic receptor adaptor activity	SHANK2 SHANK3	4.13e-05	4	53	2	GO:0030160
GeneOntologyMolecularFunction	structural constituent of synapse	SHANK2 PCLO SHANK3	1.88e-04	42	53	3	GO:0098918
GeneOntologyMolecularFunction	protein phosphatase inhibitor activity	SET PHACTR2 PHACTR1	3.17e-04	50	53	3	GO:0004864
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	SHANK2 SHANK3	3.74e-04	11	53	2	GO:0098919
GeneOntologyMolecularFunction	signaling adaptor activity	KSR1 SHANK2 STAP2 SHANK3	3.81e-04	129	53	4	GO:0035591
GeneOntologyMolecularFunction	phosphatase inhibitor activity	SET PHACTR2 PHACTR1	3.98e-04	54	53	3	GO:0019212
GeneOntologyMolecularFunction	structural constituent of postsynaptic specialization	SHANK2 SHANK3	5.29e-04	13	53	2	GO:0098879
GeneOntologyMolecularFunction	molecular adaptor activity	PHF2 DLGAP2 KSR1 DLGAP3 TRIM25 SHANK2 SH3KBP1 TPX2 STAP2 SMARCE1 SHANK3	7.33e-04	1356	53	11	GO:0060090
GeneOntologyMolecularFunction	cell adhesion molecule binding	EPS15L1 TRIM25 CD2AP TNKS1BP1 UTRN PALLD ASAP1	9.83e-04	599	53	7	GO:0050839
GeneOntologyMolecularFunction	scaffold protein binding	DLGAP3 KIF1B SHANK3	1.94e-03	93	53	3	GO:0097110
GeneOntologyMolecularFunction	cadherin binding	EPS15L1 TRIM25 CD2AP TNKS1BP1 ASAP1	2.02e-03	339	53	5	GO:0045296
GeneOntologyMolecularFunction	cytoskeletal protein binding	XIRP1 PHACTR2 CD2AP KIF1B UTRN PALLD SHANK3 MYO16 PHACTR1	2.23e-03	1099	53	9	GO:0008092
GeneOntologyMolecularFunction	protein phosphatase regulator activity	SET PHACTR2 PHACTR1	2.38e-03	100	53	3	GO:0019888
GeneOntologyMolecularFunction	structural constituent of postsynapse	SHANK2 SHANK3	3.26e-03	32	53	2	GO:0099186
GeneOntologyMolecularFunction	phosphatase regulator activity	SET PHACTR2 PHACTR1	3.37e-03	113	53	3	GO:0019208
GeneOntologyCellularComponent	podosome	CD2AP PALLD ASAP1	1.37e-04	41	51	3	GO:0002102
GeneOntologyCellularComponent	somatodendritic compartment	DLGAP2 DLGAP3 SHANK2 PCLO CD2AP EIF4B KIF1B TPX2 PALLD SHANK3 ASAP1	1.49e-04	1228	51	11	GO:0036477
GeneOntologyCellularComponent	neuromuscular junction	DLGAP3 PCLO CD2AP UTRN	1.61e-04	112	51	4	GO:0031594
GeneOntologyCellularComponent	dendrite	DLGAP2 DLGAP3 SHANK2 PCLO CD2AP EIF4B KIF1B SHANK3 ASAP1	2.05e-04	858	51	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DLGAP2 DLGAP3 SHANK2 PCLO CD2AP EIF4B KIF1B SHANK3 ASAP1	2.08e-04	860	51	9	GO:0097447
GeneOntologyCellularComponent	dendritic spine	DLGAP2 DLGAP3 SHANK2 SHANK3 ASAP1	3.04e-04	242	51	5	GO:0043197
GeneOntologyCellularComponent	neuron spine	DLGAP2 DLGAP3 SHANK2 SHANK3 ASAP1	3.34e-04	247	51	5	GO:0044309
GeneOntologyCellularComponent	neurofilament	DLGAP2 SHANK2	5.21e-04	14	51	2	GO:0005883
GeneOntologyCellularComponent	postsynapse	DOCK1 DLGAP2 DLGAP3 SHANK2 PCLO KIF1B UTRN SHANK3 ASAP1	7.14e-04	1018	51	9	GO:0098794
GeneOntologyCellularComponent	ruffle	KSR1 CD2AP FGD1 PALLD	1.59e-03	206	51	4	GO:0001726
GeneOntologyCellularComponent	excitatory synapse	PCLO PALLD SHANK3	2.27e-03	107	51	3	GO:0060076
MousePheno	abnormal synapse morphology	DLGAP2 EPS15L1 SHANK2 PCLO KIF1B UTRN SHANK3	5.72e-06	224	44	7	MP:0009538
MousePheno	decreased white fat cell number	PHF2 KSR1 ASAP1	1.58e-05	16	44	3	MP:0009131
MousePheno	abnormal white fat cell number	PHF2 KSR1 ASAP1	6.38e-05	25	44	3	MP:0009129
Domain	SH3	DOCK1 PRAM1 MYO15B SHANK2 CD2AP SH3KBP1 SHANK3 ASAP1	1.59e-07	216	53	8	SM00326
Domain	SH3	DOCK1 PRAM1 MYO15B SHANK2 CD2AP SH3KBP1 SHANK3 ASAP1	1.59e-07	216	53	8	PS50002
Domain	SH3_domain	DOCK1 PRAM1 MYO15B SHANK2 CD2AP SH3KBP1 SHANK3 ASAP1	1.83e-07	220	53	8	IPR001452
Domain	SH3_2	MYO15B SHANK2 CD2AP SH3KBP1 SHANK3	4.44e-06	86	53	5	IPR011511
Domain	SH3_2	MYO15B SHANK2 CD2AP SH3KBP1 SHANK3	4.44e-06	86	53	5	PF07653
Domain	SAPAP	DLGAP2 DLGAP3	7.86e-05	5	53	2	IPR005026
Domain	GKAP	DLGAP2 DLGAP3	7.86e-05	5	53	2	PF03359
Domain	RPEL	PHACTR2 PHACTR1	1.64e-04	7	53	2	PS51073
Domain	RPEL	PHACTR2 PHACTR1	1.64e-04	7	53	2	PF02755
Domain	RPEL	PHACTR2 PHACTR1	1.64e-04	7	53	2	SM00707
Domain	RPEL_repeat	PHACTR2 PHACTR1	1.64e-04	7	53	2	IPR004018
Domain	Znf_FYVE_PHD	PHF2 JADE2 PCLO FGD1	8.00e-04	147	53	4	IPR011011
Domain	NAP	SET SETSIP	1.05e-03	17	53	2	PF00956
Domain	NAP_family	SET SETSIP	1.05e-03	17	53	2	IPR002164
Domain	SH3_1	DOCK1 CD2AP SH3KBP1 ASAP1	1.20e-03	164	53	4	PF00018
Domain	SH3_9	DOCK1 CD2AP SH3KBP1	1.41e-03	78	53	3	PF14604
Domain	Myosin_head_motor_dom	MYO15B MYO16	5.20e-03	38	53	2	IPR001609
Domain	MYOSIN_MOTOR	MYO15B MYO16	5.20e-03	38	53	2	PS51456
Domain	Myosin_head	MYO15B MYO16	5.20e-03	38	53	2	PF00063
Domain	MYSc	MYO15B MYO16	5.20e-03	38	53	2	SM00242
Domain	PH	KIF1B STAP2 FGD1 ASAP1	7.94e-03	278	53	4	SM00233
Domain	PH_DOMAIN	KIF1B STAP2 FGD1 ASAP1	8.04e-03	279	53	4	PS50003
Domain	PH_domain	KIF1B STAP2 FGD1 ASAP1	8.14e-03	280	53	4	IPR001849
Domain	-	PHF2 TRIM25 JADE2 PCLO FGD1	8.74e-03	449	53	5	3.30.40.10
Domain	PDZ	SHANK2 PCLO SHANK3	9.03e-03	151	53	3	PS50106
Domain	PDZ	SHANK2 PCLO SHANK3	9.20e-03	152	53	3	IPR001478
Domain	Znf_RING/FYVE/PHD	PHF2 TRIM25 JADE2 PCLO FGD1	9.56e-03	459	53	5	IPR013083
Domain	HMG_BOX_2	WDHD1 SMARCE1	1.03e-02	54	53	2	PS50118
Domain	HMG	WDHD1 SMARCE1	1.03e-02	54	53	2	SM00398
Domain	-	WDHD1 SMARCE1	1.07e-02	55	53	2	1.10.30.10
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	DLGAP2 DLGAP3 SHANK3	7.83e-05	32	37	3	MM15326
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DOCK1 DLGAP2 DLGAP3 PHACTR2 SHANK2 MAP4K3 CD2AP SH3KBP1 TPX2 HMGN2 SHANK3 ASAP1	7.92e-14	329	53	12	17474147
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NHSL1 ARHGAP5 DLGAP2 DLGAP3 EPS15L1 TRIM25 ZC2HC1A SHANK2 MAP4K3 PCLO EIF4B KIF1B SH3KBP1 TNKS1BP1 STIP1 UTRN PRRC2A SHANK3 ASAP1	1.31e-13	1431	53	19	37142655
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	NHSL1 ARHGAP5 EPS15L1 PHACTR2 TRIM25 SHANK2 CD2AP EIF4B SH3KBP1 TNKS1BP1 UTRN ASAP1	4.38e-11	565	53	12	25468996
Pubmed	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	DLGAP2 DLGAP3 SHANK2 SHANK3	1.68e-10	7	53	4	10527873
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	DOCK1 EPS15L1 ZC2HC1A ZC3H13 TPX2 TNKS1BP1 BCAR3 SRRM2 PRRC2A PALLD	4.09e-09	503	53	10	16964243
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK1 ARHGAP5 EPS15L1 CD2AP SH3KBP1 TPX2 FGD1 SMARCE1 STIP1 UTRN PRRC2A ASAP1	1.03e-08	916	53	12	32203420
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP2 DLGAP3 SHANK2 PCLO STIP1 SHANK3 ASAP1 PHACTR1	1.06e-08	281	53	8	28706196
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPS15L1 TRIM25 EIF4B TPX2 PTPN23 SMARCE1 HMGN2 TNKS1BP1 STIP1 UTRN PRRC2A PALLD	1.27e-08	934	53	12	33916271
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	WDHD1 EIF4B TPX2 TNKS1BP1 UTRN PALLD	2.70e-08	118	53	6	30979931
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ARHGAP5 EPS15L1 FAM184A TRIM25 ZC2HC1A MAP4K3 CD2AP EIF4B KIF1B PTPN23 ASAP1	5.40e-08	853	53	11	28718761
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ARHGAP5 SET WDHD1 MAP4K3 ZC3H13 CD2AP EIF4B PTPN23 ZMYM1 UTRN ASAP1 PHACTR1	6.49e-08	1084	53	12	11544199
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	EPS15L1 SET ZC2HC1A CD2AP EIF4B KIF1B PTPN23 SMARCE1 HMGN2 STIP1 UTRN PALLD ASAP1	9.80e-08	1367	53	13	32687490
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 EPS15L1 CD2AP EIF4B KIF1B PTPN23 TNKS1BP1 STIP1 PRRC2A PALLD	1.02e-07	708	53	10	39231216
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	NHSL1 DLGAP2 DLGAP3 EPS15L1 SHANK2 PCLO EIF4B SH3KBP1 STIP1 SHANK3 ASAP1 PHACTR1	1.11e-07	1139	53	12	36417873
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SET ZC3H13 SMARCE1 TNKS1BP1 STIP1 SRRM2 PRRC2A PALLD	1.58e-07	399	53	8	35987950
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PHF2 PRAM1 EPS15L1 ZC3H13 CD2AP EIF4B TPX2 SMARCE1 HMGN2 SRRM2 PRRC2A	1.66e-07	954	53	11	36373674
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PHF2 FAM184A SET GPBP1L1 TRIM25 SHANK2 CD2AP EIF4B TPX2 SMARCE1 STIP1 UTRN PRRC2A	2.78e-07	1497	53	13	31527615
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	SET SETSIP SMARCE1 HMGN2 STIP1 SRRM2	3.32e-07	180	53	6	30110629
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	DOCK1 EPS15L1 MAP4K3 CD2AP ASAP1	5.29e-07	103	53	5	21706016
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	DLGAP2 DLGAP3 SHANK2 SH3KBP1 TNKS1BP1 SHANK3	5.63e-07	197	53	6	36604605
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NHSL1 KSR1 PHACTR2 CD2AP EIF4B KIF1B TNKS1BP1 SRRM2 UTRN PALLD	6.11e-07	861	53	10	36931259
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SET PHACTR2 WDHD1 TPX2 SMARCE1 HMGN2 SRRM2 UTRN	9.48e-07	506	53	8	30890647
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	EPS15L1 SHANK2 PCLO SH3KBP1 TNKS1BP1 SRRM2 PRRC2A	9.63e-07	347	53	7	17114649
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	EPS15L1 CD2AP KIF1B TNKS1BP1 SRRM2 UTRN PRRC2A	1.23e-06	360	53	7	33111431
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZC3H13 EIF4B HMGN2 STIP1 SRRM2 PRRC2A PALLD	1.25e-06	361	53	7	26167880
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	EPS15L1 SHANK2 PCLO SRRM2 PRRC2A PHACTR1	1.42e-06	231	53	6	16452087
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DLGAP2 DLGAP3 EPS15L1 ZC2HC1A SHANK2 SH3KBP1 STIP1 PRRC2A SHANK3 PHACTR1	1.68e-06	963	53	10	28671696
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EPS15L1 CD2AP TPX2 PTPN23 SMARCE1 TNKS1BP1 PRRC2A PALLD	1.74e-06	549	53	8	38280479
Pubmed	CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.	CD2AP SH3KBP1	2.28e-06	2	53	2	27531950
Pubmed	Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development.	SHANK2 SHANK3	2.28e-06	2	53	2	10506216
Pubmed	Expression profiles of the autism-related SHANK proteins in the human brain.	SHANK2 SHANK3	2.28e-06	2	53	2	37953224
Pubmed	CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.	CD2AP SH3KBP1	2.28e-06	2	53	2	17213204
Pubmed	Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.	SHANK2 SHANK3	2.28e-06	2	53	2	36100669
Pubmed	Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.	SHANK2 SHANK3	2.28e-06	2	53	2	22699619
Pubmed	Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.	SHANK2 SHANK3	2.28e-06	2	53	2	33126897
Pubmed	Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system.	SHANK2 SHANK3	2.28e-06	2	53	2	20800661
Pubmed	Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.	SHANK2 SHANK3	2.28e-06	2	53	2	31052177
Pubmed	Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus.	SHANK2 SHANK3	2.28e-06	2	53	2	27199660
Pubmed	SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis.	SHANK2 SHANK3	2.28e-06	2	53	2	36845137
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EPS15L1 WDHD1 ZC3H13 EIF4B KIF1B TPX2 TNKS1BP1 SRRM2 PRRC2A	2.36e-06	774	53	9	15302935
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DOCK1 DLGAP2 TRIM25 DPPA4 TPX2 ZMYM1 ASAP1	3.97e-06	430	53	7	35044719
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	CD2AP EIF4B TPX2 UTRN PRRC2A	4.51e-06	159	53	5	30581152
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	EPS15L1 ZNF608 CD2AP EIF4B TNKS1BP1 ZMYM1 PALLD	4.90e-06	444	53	7	34795231
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PHF2 PRAM1 SET TRIM25 EIF4B TPX2 SMARCE1 HMGN2 SRRM2 PRRC2A	5.58e-06	1103	53	10	34189442
Pubmed	Modeling autism by SHANK gene mutations in mice.	SHANK2 SHANK3	6.83e-06	3	53	2	23583105
Pubmed	The Shank family of scaffold proteins.	SHANK2 SHANK3	6.83e-06	3	53	2	10806096
Pubmed	Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.	CD2AP SH3KBP1	6.83e-06	3	53	2	24039852
Pubmed	Inhibition of T cell activation and function by the adaptor protein CIN85.	CD2AP SH3KBP1	6.83e-06	3	53	2	30723173
Pubmed	The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.	CD2AP SH3KBP1	6.83e-06	3	53	2	31142511
Pubmed	CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.	CD2AP SH3KBP1	6.83e-06	3	53	2	16895919
Pubmed	Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.	SHANK2 SHANK3	6.83e-06	3	53	2	29970989
Pubmed	S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.	SHANK2 SHANK3	6.83e-06	3	53	2	34741005
Pubmed	Translational neurobiology in Shank mutant mice--model systems for neuropsychiatric disorders.	SHANK2 SHANK3	6.83e-06	3	53	2	25917711
Pubmed	Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.	SHANK2 SHANK3	6.83e-06	3	53	2	32564287
Pubmed	Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.	CD2AP SH3KBP1 ASAP1	7.51e-06	25	53	3	12029088
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	TRIM25 EIF4B TNKS1BP1 STIP1 PRRC2A PALLD	8.45e-06	315	53	6	26777405
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SET EIF4B KIF1B STIP1 UTRN PALLD ASAP1	1.02e-05	497	53	7	23414517
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	TRIM25 WDHD1 TPX2 STIP1 SRRM2 PALLD	1.14e-05	332	53	6	32786267
Pubmed	Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.	CD2AP SH3KBP1	1.36e-05	4	53	2	17606992
Pubmed	Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.	CD2AP SH3KBP1	1.36e-05	4	53	2	23663663
Pubmed	Identification of CMS as a cytosolic adaptor of the human pTalpha chain involved in pre-TCR function.	CD2AP SH3KBP1	1.36e-05	4	53	2	17823309
Pubmed	SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.	SHANK2 SHANK3	1.36e-05	4	53	2	23897824
Pubmed	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.	SHANK2 SHANK3	1.36e-05	4	53	2	12626503
Pubmed	Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.	SHANK2 SHANK3	1.36e-05	4	53	2	23468870
Pubmed	Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.	CD2AP SH3KBP1	1.36e-05	4	53	2	12690097
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	SET TRIM25 EIF4B TNKS1BP1 STIP1 UTRN PALLD	1.70e-05	538	53	7	28524877
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	NHSL1 MAP4K3 PCLO KIF1B MYO16	2.08e-05	218	53	5	33378226
Pubmed	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.	SHANK2 SHANK3	2.27e-05	5	53	2	12504591
Pubmed	CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities.	CD2AP SH3KBP1	2.27e-05	5	53	2	12618476
Pubmed	Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.	DLGAP2 SHANK2	2.27e-05	5	53	2	33347690
Pubmed	Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.	SHANK2 SHANK3	2.27e-05	5	53	2	16606358
Pubmed	Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.	CD2AP SH3KBP1	2.27e-05	5	53	2	23279575
Pubmed	Functional impact of global rare copy number variation in autism spectrum disorders.	DLGAP2 SHANK2	2.27e-05	5	53	2	20531469
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CD2AP SH3KBP1	2.27e-05	5	53	2	17020880
Pubmed	Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse.	DLGAP2 DLGAP3	2.27e-05	5	53	2	15024750
Pubmed	Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling.	CD2AP ASAP1	2.27e-05	5	53	2	15632162
Pubmed	CD2AP regulates SUMOylation of CIN85 in podocytes.	CD2AP SH3KBP1	2.27e-05	5	53	2	22203040
Pubmed	CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.	CD2AP SH3KBP1	2.27e-05	5	53	2	20457601
Pubmed	Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.	DOCK1 FGD1	2.27e-05	5	53	2	12134158
Pubmed	Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.	CD2AP SH3KBP1	2.27e-05	5	53	2	24167568
Pubmed	Genome-wide linkage and association scans for pulse pressure in Chinese twins.	MYO16 PHACTR1	2.27e-05	5	53	2	22763476
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	SH3KBP1 SRRM2 PRRC2A ASAP1	2.29e-05	108	53	4	19531213
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	KSR1 EPS15L1 GPBP1L1 ZC2HC1A SHANK2 WDHD1 EIF4B SMARCE1 TNKS1BP1	2.47e-05	1038	53	9	26673895
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHF2 NHSL1 ARHGAP5 PTPN23 STIP1 SRRM2 UTRN PRRC2A ASAP1	2.68e-05	1049	53	9	27880917
Pubmed	Aberrant RNA methylation triggers recruitment of an alkylation repair complex.	EIF4B SRRM2	3.40e-05	6	53	2	34686315
Pubmed	Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.	CD2AP SH3KBP1	3.40e-05	6	53	2	17428861
Pubmed	E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.	CD2AP SH3KBP1	3.40e-05	6	53	2	33627783
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ARHGAP5 SET JADE2 ZC3H13 TPX2 SMARCE1 SRRM2 PRRC2A	4.03e-05	847	53	8	35850772
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DLGAP2 DLGAP3 SHANK2 SH3KBP1 SHANK3	4.07e-05	251	53	5	27507650
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	EPS15L1 CD2AP EIF4B TPX2 TNKS1BP1	4.47e-05	256	53	5	33397691
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SET TRIM25 EIF4B PTPN23 SMARCE1 TNKS1BP1 STIP1 SRRM2 PRRC2A PALLD	4.75e-05	1415	53	10	28515276
Pubmed	Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins.	PHACTR2 PHACTR1	4.76e-05	7	53	2	15107502
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	SHANK2 SHANK3	4.76e-05	7	53	2	15207857
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	SH3KBP1 ASAP1	4.76e-05	7	53	2	17255943
Pubmed	Different expression patterns of Phactr family members in normal and injured mouse brain.	PHACTR2 PHACTR1	4.76e-05	7	53	2	22766235
Pubmed	SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.	DLGAP2 DLGAP3	4.76e-05	7	53	2	9115257
Pubmed	Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.	CD2AP SH3KBP1	4.76e-05	7	53	2	20654576
Pubmed	Functional genomic screen for modulators of ciliogenesis and cilium length.	PTPN23 ASAP1	4.76e-05	7	53	2	20393563
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	DLGAP2 DLGAP3 PCLO SHANK3	4.88e-05	131	53	4	28634551
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	EPS15L1 ZC3H13 SH3KBP1 SRRM2	5.18e-05	133	53	4	15144186
Interaction	CDH1 interactions	NHSL1 ARHGAP5 EPS15L1 SET PHACTR2 TRIM25 ZC2HC1A SHANK2 ZNF608 CD2AP EIF4B SH3KBP1 TNKS1BP1 UTRN ASAP1	7.34e-10	768	53	15	int:CDH1
Interaction	KCTD13 interactions	NHSL1 ARHGAP5 DLGAP2 DLGAP3 EPS15L1 TRIM25 ZC2HC1A SHANK2 MAP4K3 PCLO EIF4B KIF1B SH3KBP1 TNKS1BP1 STIP1 UTRN PRRC2A SHANK3 ASAP1	9.91e-10	1394	53	19	int:KCTD13
Interaction	SH3GL2 interactions	MAP4K3 DPPA4 CD2AP SH3KBP1 PTPN23 SHANK3 ASAP1	3.11e-09	88	53	7	int:SH3GL2
Interaction	VASP interactions	NHSL1 ARHGAP5 XIRP1 TRIM25 PTPN23 TNKS1BP1 STIP1 HS1BP3 PALLD	6.69e-08	294	53	9	int:VASP
Interaction	TSG101 interactions	TRIM25 CD2AP EIF4B SH3KBP1 PTPN23 HMGN2 TNKS1BP1 PALLD SHANK3	8.65e-08	303	53	9	int:TSG101
Interaction	PTK2 interactions	DOCK1 DLGAP3 TRIM25 SH3KBP1 STAP2 PTPN23 STIP1 SRRM2 ASAP1	1.20e-07	315	53	9	int:PTK2
Interaction	SHANK2 interactions	DLGAP2 DLGAP3 TRIM25 SHANK2 SHANK3	3.26e-07	55	53	5	int:SHANK2
Interaction	DNM2 interactions	SET TRIM25 SHANK2 CD2AP SH3KBP1 STIP1 SHANK3 ASAP1	8.01e-07	288	53	8	int:DNM2
Interaction	AGAP2 interactions	DLGAP2 DLGAP3 SHANK2 PCLO SHANK3 ASAP1 PHACTR1	1.24e-06	210	53	7	int:AGAP2
Interaction	ENO1 interactions	DLGAP3 SET TRIM25 MAP4K3 EIF4B KIF1B SH3KBP1 SMARCE1 STIP1 PRRC2A SHANK3	1.68e-06	701	53	11	int:ENO1
Interaction	ARHGAP27 interactions	TRIM25 SH3KBP1 HMGN2	2.79e-06	11	53	3	int:ARHGAP27
Interaction	CSNK2A1 interactions	SET SETSIP JADE2 ZC3H13 CD2AP EIF4B KIF1B SH3KBP1 TNKS1BP1 STIP1 SRRM2 SHANK3	5.34e-06	956	53	12	int:CSNK2A1
Interaction	PHACTR1 interactions	TRIM25 EIF4B PHACTR1	6.12e-06	14	53	3	int:PHACTR1
Interaction	GRB2 interactions	DOCK1 EPS15L1 TRIM25 MAP4K3 DPPA4 CD2AP SH3KBP1 PTPN23 PRRC2A SHANK3 ASAP1	6.41e-06	806	53	11	int:GRB2
Interaction	NAA40 interactions	EPS15L1 TRIM25 EIF4B TPX2 PTPN23 SMARCE1 HMGN2 TNKS1BP1 STIP1 UTRN PRRC2A PALLD	6.73e-06	978	53	12	int:NAA40
Interaction	SH3RF1 interactions	PRAM1 XIRP1 TRIM25 MAP4K3 FGD1	9.42e-06	108	53	5	int:SH3RF1
Interaction	ABI2 interactions	NHSL1 PRAM1 DLGAP2 MYO15B TRIM25 SH3KBP1 SHANK3	9.50e-06	286	53	7	int:ABI2
Interaction	ACTC1 interactions	SET PHACTR2 WDHD1 CD2AP SH3KBP1 TPX2 SMARCE1 HMGN2 SRRM2 UTRN	1.12e-05	694	53	10	int:ACTC1
Interaction	NHSL3 interactions	NHSL1 SET TRIM25 SH3KBP1 ASAP1	1.17e-05	113	53	5	int:NHSL3
Interaction	CDKL5 interactions	DLGAP2 DLGAP3 TRIM25 SHANK2 SH3KBP1	1.17e-05	113	53	5	int:CDKL5
Interaction	BCAR1 interactions	DOCK1 PRAM1 TRIM25 CD2AP SH3KBP1 PTPN23 HMGN2 HS1BP3 BCAR3	1.30e-05	556	53	9	int:BCAR1
Interaction	SYNGAP1 interactions	DOCK1 DLGAP2 DLGAP3 SHANK2 SH3KBP1 STIP1 SHANK3	1.50e-05	307	53	7	int:SYNGAP1
Interaction	YWHAG interactions	NHSL1 KSR1 PHACTR2 GPBP1L1 MAP4K3 ZC3H13 CD2AP EIF4B KIF1B STIP1 SRRM2 UTRN SHANK3	1.52e-05	1248	53	13	int:YWHAG
Interaction	H2BC9 interactions	PHACTR2 PCLO EIF4B HMGN2 STIP1 PRRC2A PALLD PHACTR1	2.00e-05	446	53	8	int:H2BC9
Interaction	YWHAH interactions	NHSL1 KSR1 PHACTR2 GPBP1L1 ZC3H13 CD2AP EIF4B KIF1B TNKS1BP1 SRRM2 UTRN PALLD	2.23e-05	1102	53	12	int:YWHAH
Interaction	ARHGAP12 interactions	SHANK2 PALLD SHANK3 ASAP1	3.06e-05	68	53	4	int:ARHGAP12
Interaction	WASF2 interactions	DOCK1 NHSL1 TRIM25 UTRN SHANK3	4.04e-05	146	53	5	int:WASF2
Interaction	SMC5 interactions	PHF2 PRAM1 EPS15L1 ZC3H13 CD2AP EIF4B TPX2 SMARCE1 HMGN2 SRRM2 PRRC2A	4.75e-05	1000	53	11	int:SMC5
Interaction	CRK interactions	DOCK1 TRIM25 DPPA4 CD2AP SH3KBP1 BCAR3 ASAP1	4.95e-05	370	53	7	int:CRK
Interaction	PFN1 interactions	DOCK1 NHSL1 ARHGAP5 SET TRIM25 PCLO TNKS1BP1 PALLD	5.11e-05	509	53	8	int:PFN1
Interaction	SRC interactions	DOCK1 TRIM25 CD2AP SH3KBP1 STAP2 PTPN23 SMARCE1 SHANK3 ASAP1	5.25e-05	664	53	9	int:SRC
Interaction	ITSN1 interactions	EPS15L1 TRIM25 SH3KBP1 PTPN23 SHANK3 ASAP1	5.89e-05	259	53	6	int:ITSN1
Interaction	MEN1 interactions	ARHGAP5 SET WDHD1 ZNF608 JADE2 ZC3H13 TPX2 SMARCE1 TNKS1BP1 SRRM2 PRRC2A	6.16e-05	1029	53	11	int:MEN1
Interaction	DLG2 interactions	DLGAP2 DLGAP3 KIF1B SHANK3	6.72e-05	83	53	4	int:DLG2
Interaction	DLGAP4 interactions	DLGAP2 TRIM25 SHANK2 SHANK3	7.04e-05	84	53	4	int:DLGAP4
Interaction	KCNA3 interactions	DOCK1 EPS15L1 CD2AP EIF4B KIF1B PTPN23 TNKS1BP1 STIP1 PRRC2A PALLD	7.77e-05	871	53	10	int:KCNA3
Interaction	TNRC6B interactions	DLGAP2 FAM184A GPBP1L1 PTPN23 TNKS1BP1 PRRC2A	9.41e-05	282	53	6	int:TNRC6B
Interaction	SRGAP1 interactions	DOCK1 TRIM25 CD2AP SH3KBP1	1.00e-04	92	53	4	int:SRGAP1
Interaction	DLGAP1 interactions	DLGAP2 DLGAP3 SHANK2 SH3KBP1 SHANK3	1.09e-04	180	53	5	int:DLGAP1
Interaction	IMPDH2 interactions	TRIM25 CD2AP EIF4B SH3KBP1 PTPN23 BCAR3 PALLD	1.10e-04	420	53	7	int:IMPDH2
Interaction	WWTR1 interactions	EPS15L1 TRIM25 CD2AP PTPN23 SMARCE1 TNKS1BP1 PRRC2A	1.13e-04	422	53	7	int:WWTR1
Interaction	BICD2 interactions	TRIM25 ZC2HC1A MAP4K3 CD2AP EIF4B PTPN23 ASAP1	1.20e-04	426	53	7	int:BICD2
Interaction	MICALL1 interactions	KSR1 TRIM25 CD2AP SH3KBP1	1.23e-04	97	53	4	int:MICALL1
Interaction	GNAL interactions	DOCK1 TRIM25 SHANK3	1.25e-04	37	53	3	int:GNAL
Interaction	ASAP1 interactions	TRIM25 CD2AP SH3KBP1 ASAP1	1.28e-04	98	53	4	int:ASAP1
Interaction	DLGAP2 interactions	DLGAP2 SHANK2 SHANK3	1.47e-04	39	53	3	int:DLGAP2
Interaction	KLF5 interactions	SET TRIM25 ZNF608 SMARCE1 PRRC2A	1.59e-04	195	53	5	int:KLF5
Interaction	TARS1 interactions	SET TRIM25 HMGN2 STIP1 BCAR3	1.59e-04	195	53	5	int:TARS1
Interaction	TNIP2 interactions	PHF2 SET TRIM25 ZC3H13 EIF4B SH3KBP1 STIP1 SRRM2 PRRC2A SHANK3	1.62e-04	952	53	10	int:TNIP2
Interaction	MED4 interactions	EPS15L1 FAM184A TRIM25 ZC3H13 CD2AP SMARCE1 UTRN	1.68e-04	450	53	7	int:MED4
Interaction	ARHGAP44 interactions	CD2AP SH3KBP1 SHANK3	1.71e-04	41	53	3	int:ARHGAP44
Interaction	PRNP interactions	NHSL1 KSR1 EPS15L1 XIRP1 WDHD1 CD2AP EIF4B SH3KBP1 STIP1 SRRM2 SHANK3	1.76e-04	1158	53	11	int:PRNP
Interaction	SRRM3 interactions	TRIM25 SRRM2	1.88e-04	8	53	2	int:SRRM3
Interaction	AGFG1 interactions	EPS15L1 TRIM25 EIF4B PTPN23	2.00e-04	110	53	4	int:AGFG1
Interaction	SORBS2 interactions	DLGAP2 CD2AP PALLD SHANK3	2.07e-04	111	53	4	int:SORBS2
Interaction	DLGAP3 interactions	DLGAP3 SHANK2 SHANK3	2.11e-04	44	53	3	int:DLGAP3
Interaction	PHLPP1 interactions	EPS15L1 TRIM25 CD2AP EIF4B TPX2 TNKS1BP1	2.32e-04	333	53	6	int:PHLPP1
Interaction	INPPL1 interactions	TRIM25 MAP4K3 CD2AP SH3KBP1 PTPN23	2.44e-04	214	53	5	int:INPPL1
Interaction	WASF1 interactions	NHSL1 TRIM25 SHANK3 MYO16	2.45e-04	116	53	4	int:WASF1
Interaction	SOS1 interactions	DOCK1 EPS15L1 CD2AP SH3KBP1	2.54e-04	117	53	4	int:SOS1
Interaction	CBX3 interactions	SET ZC3H13 TPX2 SMARCE1 HMGN2 TNKS1BP1 ZMYM1 SRRM2	2.65e-04	646	53	8	int:CBX3
Interaction	PTK2B interactions	ARHGAP5 DLGAP3 SH3KBP1 ASAP1	2.71e-04	119	53	4	int:PTK2B
Interaction	CEBPB interactions	KSR1 SET TRIM25 WDHD1 EIF4B TPX2 SMARCE1 HMGN2 STIP1 SRRM2 PRRC2A PALLD	2.95e-04	1443	53	12	int:CEBPB
Interaction	BRD3 interactions	PHF2 SET TRIM25 TPX2 SMARCE1 HMGN2 SRRM2	2.96e-04	494	53	7	int:BRD3
Interaction	RAPGEF4 interactions	DOCK1 PCLO SHANK3	3.08e-04	50	53	3	int:RAPGEF4
Interaction	CRKL interactions	DOCK1 MAP4K3 SH3KBP1 SHANK3 ASAP1	3.21e-04	227	53	5	int:CRKL
Interaction	SEPTIN7 interactions	SH3KBP1 STAP2 STIP1 SRRM2 SHANK3	3.27e-04	228	53	5	int:SEPTIN7
Interaction	TOLLIP interactions	EIF4B TPX2 PTPN23 HMGN2 TNKS1BP1 PALLD	3.42e-04	358	53	6	int:TOLLIP
Interaction	GAGE5 interactions	ZC3H13 TPX2 PRRC2A	3.47e-04	52	53	3	int:GAGE5
Interaction	SH3PXD2A interactions	KSR1 TRIM25 KIF1B FGD1	3.57e-04	128	53	4	int:SH3PXD2A
Interaction	UQCR11 interactions	KSR1 ZC3H13 PRRC2A	3.67e-04	53	53	3	int:UQCR11
Interaction	PHF20 interactions	TRIM25 ZNF608 JADE2	3.67e-04	53	53	3	int:PHF20
Interaction	MAPRE1 interactions	ZC2HC1A CD2AP EIF4B KIF1B SMARCE1 SRRM2 PRRC2A	3.76e-04	514	53	7	int:MAPRE1
Interaction	DLG1 interactions	DLGAP2 DLGAP3 KIF1B SHANK3 ASAP1	4.14e-04	240	53	5	int:DLG1
Interaction	NOTCH2NLA interactions	MYO15B TRIM25 TMIE PTPN23 SMARCE1 SHANK3	4.76e-04	381	53	6	int:NOTCH2NLA
Interaction	YAP1 interactions	EPS15L1 CD2AP EIF4B TPX2 SMARCE1 TNKS1BP1 STIP1 SRRM2 PRRC2A PALLD	4.95e-04	1095	53	10	int:YAP1
Interaction	H2BC17 interactions	JADE2 PCLO EIF4B HMGN2	5.02e-04	140	53	4	int:H2BC17
Interaction	PACSIN1 interactions	JADE2 SHANK3 ASAP1	5.29e-04	60	53	3	int:PACSIN1
Interaction	DCAF15 interactions	EPS15L1 CD2AP EIF4B SH3KBP1 UTRN	5.45e-04	255	53	5	int:DCAF15
Interaction	SH3GL3 interactions	MAP4K3 DPPA4 SH3KBP1 SHANK3	5.73e-04	145	53	4	int:SH3GL3
Interaction	DYRK1A interactions	TRIM25 WDHD1 EIF4B TPX2 TNKS1BP1 UTRN PALLD	5.76e-04	552	53	7	int:DYRK1A
Interaction	YWHAQ interactions	NHSL1 KSR1 PHACTR2 TRIM25 WDHD1 ZC3H13 EIF4B KIF1B STIP1 SHANK3	5.83e-04	1118	53	10	int:YWHAQ
Interaction	H2BC4 interactions	WDHD1 EIF4B HMGN2 SRRM2 PRRC2A	5.85e-04	259	53	5	int:H2BC4
Interaction	RUNDC3A interactions	EPS15L1 MYO15B SHANK3	6.10e-04	63	53	3	int:RUNDC3A
Interaction	NCK2 interactions	DOCK1 NHSL1 ZC2HC1A PRRC2A ASAP1	6.16e-04	262	53	5	int:NCK2
Interaction	ARAP3 interactions	CD2AP SH3KBP1 ASAP1	6.39e-04	64	53	3	int:ARAP3
Interaction	SPAG9 interactions	EPS15L1 TRIM25 WDHD1 CD2AP STIP1	6.83e-04	268	53	5	int:SPAG9
Interaction	PIK3R1 interactions	TRIM25 WDHD1 CD2AP SH3KBP1 TPX2 MYO16	7.18e-04	412	53	6	int:PIK3R1
Interaction	SH3PXD2B interactions	GPBP1L1 SH3KBP1 SHANK3	7.63e-04	68	53	3	int:SH3PXD2B
Interaction	SPTBN1 interactions	TRIM25 KIF1B TNKS1BP1 STIP1 SRRM2 SHANK3	8.03e-04	421	53	6	int:SPTBN1
Interaction	PFN2 interactions	TRIM25 PCLO PALLD SHANK3	8.09e-04	159	53	4	int:PFN2
Interaction	PCLO interactions	DPPA4 PCLO HMGN2	8.30e-04	70	53	3	int:PCLO
Interaction	KANSL2 interactions	GPBP1L1 TRIM25 ZNF608	8.30e-04	70	53	3	int:KANSL2
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	NHSL1 PHACTR2 UTRN	1.04e-04	78	53	3	chr6q24
Cytoband	1p22.1	SETSIP BCAR3	6.34e-04	32	53	2	1p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	DLGAP3 GPBP1L1 ZMYM1	4.81e-03	294	53	3	chr1p34
GeneFamily	Phosphatase and actin regulators	PHACTR2 PHACTR1	1.70e-05	4	31	2	679
GeneFamily	Ankyrin repeat domain containing	SHANK2 SHANK3 MYO16 ASAP1	7.42e-04	242	31	4	403
GeneFamily	PDZ domain containing	SHANK2 PCLO SHANK3	2.20e-03	152	31	3	1220
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KIF1B FGD1 ASAP1	5.18e-03	206	31	3	682
GeneFamily	Sterile alpha motif domain containing	SHANK2 SHANK3	9.94e-03	88	31	2	760
GeneFamily	PHD finger proteins	PHF2 JADE2	1.04e-02	90	31	2	88
Coexpression	CAMP_UP.V1_DN	ARHGAP5 MYO15B PCLO EIF4B STIP1 PALLD	2.70e-06	199	52	6	M2719
Coexpression	GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_DN	TMIE KIF1B	3.85e-05	5	52	2	MM727
Coexpression	GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_DN	TMIE KIF1B	3.85e-05	5	52	2	M1740
Coexpression	HALLMARK_MITOTIC_SPINDLE	ARHGAP5 CD2AP KIF1B TPX2 PALLD	4.67e-05	199	52	5	M5893
Coexpression	GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_DN	PHF2 ARHGAP5 PHACTR2 ZFR2 ASAP1	4.67e-05	199	52	5	M9288
Coexpression	GSE17721_LPS_VS_POLYIC_16H_BMDC_DN	TRIM25 TPX2 STAP2 HS1BP3 UTRN	4.78e-05	200	52	5	M3819
Coexpression	ZHONG_PFC_C3_MICROGLIA	FAM184A ZC2HC1A SHANK2 ZFR2 PCLO KIF1B MYO16	4.82e-05	488	52	7	M39104
Coexpression	KONDO_EZH2_TARGETS	ARHGAP5 MAP4K3 PCLO SRRM2 MYO16	9.06e-05	229	52	5	M5301
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NHSL1 FAM184A SHANK2 ZNF608 PHACTR1	1.96e-06	173	53	5	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PHF2 ARHGAP5 EPS15L1 MYO15B CD2AP	2.87e-06	187	53	5	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 FAM184A SHANK2 ZNF608 PHACTR1	3.10e-06	190	53	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 FAM184A SHANK2 ZNF608 PHACTR1	3.18e-06	191	53	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	mLN-B_cell-B_cell_cycling\|mLN / Region, Cell class and subclass	TRIM25 SHANK2 TPX2 BCAR3 PALLD	3.70e-06	197	53	5	806dddcca85c82bd642008d930c8db16b613d88e
ToppCell	mLN-(2)_B_cell-(24)_B_cell_cycling\|mLN / shred on region, Cell_type, and subtype	TRIM25 SHANK2 TPX2 BCAR3 PALLD	3.70e-06	197	53	5	70fff2d6723f259e18e7a21d22dc46d71f0759ce
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	PHACTR2 ZC3H13 CD2AP SMARCE1 UTRN	3.79e-06	198	53	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 NHSL1 FAM184A SHANK2 PHACTR1	3.89e-06	199	53	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	PHACTR2 ZC3H13 PCLO SMARCE1 UTRN	3.89e-06	199	53	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP5 KSR1 ZMYM1 UTRN	4.55e-05	166	53	4	3b750d4023a0a09d86113aae5a97d84391f7b482
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLGAP2 DPPA4 PCLO SHANK3	4.99e-05	170	53	4	5bb577e2c4bd275fbe4ee23ff8c007b2fcb90e56
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLGAP2 DPPA4 PCLO SHANK3	5.46e-05	174	53	4	66df78280f657978c4a568010ae7d7943869af90
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYO15B TRIM25 PTPN23 PHACTR1	5.58e-05	175	53	4	87e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	NHSL1 DLGAP2 SHANK3 ASAP1	5.71e-05	176	53	4	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	NHSL1 DLGAP2 SHANK3 ASAP1	5.71e-05	176	53	4	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK2 CCDC80 UTRN MYO16	5.83e-05	177	53	4	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 TPX2 STAP2 HMGN2	5.83e-05	177	53	4	b41e975e8368e2618b015be095efe8c0e001c78b
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 TPX2 STAP2 HMGN2	5.83e-05	177	53	4	15d1de38e4f1a0d4a786d83ee92240f44bdff006
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 CD2AP SRRM2 UTRN	5.96e-05	178	53	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 DLGAP3 PCLO SHANK3	5.96e-05	178	53	4	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 DLGAP3 PCLO SHANK3	5.96e-05	178	53	4	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	6.09e-05	179	53	4	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF608 CD2AP SH3KBP1 ASAP1	6.50e-05	182	53	4	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK2 CD2AP TNKS1BP1 UTRN	6.78e-05	184	53	4	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHANK2 UTRN MYO16 PHACTR1	6.78e-05	184	53	4	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF608 CD2AP SH3KBP1 UTRN	6.78e-05	184	53	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHANK2 UTRN MYO16 PHACTR1	6.78e-05	184	53	4	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF608 CD2AP SH3KBP1 ASAP1	6.92e-05	185	53	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	7.07e-05	186	53	4	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 ZNF608 CD2AP UTRN	7.07e-05	186	53	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHANK2 ZNF608 MYO16 PHACTR1	7.22e-05	187	53	4	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	7.22e-05	187	53	4	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	PHF2 ARHGAP5 MYO15B CD2AP	7.22e-05	187	53	4	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pre_pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	JADE2 TPX2 HMGN2 STIP1	7.37e-05	188	53	4	9858940c616e43441644c5a3bea8d832ee4daf79
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHANK2 PALLD MYO16 PHACTR1	7.68e-05	190	53	4	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	7.83e-05	191	53	4	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	7.83e-05	191	53	4	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PRAM1 DPPA4 KIF1B TPX2	7.99e-05	192	53	4	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 PCLO SRRM2 PHACTR1	7.99e-05	192	53	4	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAM184A SHANK2 ZNF608 PHACTR1	7.99e-05	192	53	4	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 FAM184A SHANK2 PHACTR1	7.99e-05	192	53	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 CD2AP CCDC80 SRRM2	8.15e-05	193	53	4	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 CD2AP CCDC80 SRRM2	8.15e-05	193	53	4	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 CD2AP CCDC80 SRRM2	8.15e-05	193	53	4	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLGAP2 UTRN SHANK3 ASAP1	8.15e-05	193	53	4	bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 CD2AP CCDC80 SRRM2	8.15e-05	193	53	4	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP3 MAP4K3 CD2AP BCAR3	8.32e-05	194	53	4	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP3 MAP4K3 CD2AP BCAR3	8.32e-05	194	53	4	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 PCLO SRRM2 PHACTR1	8.32e-05	194	53	4	92b39a935e8c577eb1123d706d168fa13cf3344c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK1 ZNF608 SHANK3 PHACTR1	8.32e-05	194	53	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon\|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.	NHSL1 ZC3H13 PCLO EIF4B	8.32e-05	194	53	4	4903a0d6e36599bcb83b179462e5b949df9eb685
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO KIF1B SRRM2 PHACTR1	8.49e-05	195	53	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO KIF1B SRRM2 PHACTR1	8.49e-05	195	53	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 SHANK2 PCLO PHACTR1	8.65e-05	196	53	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	T_cells-Treg_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ARHGAP5 FAM184A PHACTR2 ZC2HC1A	8.83e-05	197	53	4	ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC80 UTRN PALLD ASAP1	8.83e-05	197	53	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 SHANK2 PCLO PHACTR1	9.00e-05	198	53	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	PBMC_fresh-frozen\|World / Compartment, severity and other cell annotations on 10x 3' data (130k)	SET EIF4B HMGN2 UTRN	9.00e-05	198	53	4	dcc223a0396b8b673e4ed8c6733ec6cd74e9a03a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 SHANK2 PCLO PHACTR1	9.00e-05	198	53	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	wk_08-11-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NHSL1 FAM184A UTRN CLDN23	9.00e-05	198	53	4	84697f316d9195ebe838cf57f4dbdd9feea43bec
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 NHSL1 SHANK2 MAP4K3	9.00e-05	198	53	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	wk_08-11-Epithelial-Distal_epithelial_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NHSL1 FAM184A UTRN CLDN23	9.00e-05	198	53	4	eda85a592527992b51a00f288cff0c3239c47e6f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NHSL1 FAM184A SHANK2 PHACTR1	9.18e-05	199	53	4	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NHSL1 FAM184A SHANK2 PHACTR1	9.18e-05	199	53	4	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NHSL1 FAM184A SHANK2 PHACTR1	9.18e-05	199	53	4	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 SHANK2 MAP4K3 UTRN	9.18e-05	199	53	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	PHACTR2 ZC3H13 CD2AP SMARCE1	9.18e-05	199	53	4	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	DLGAP2 SHANK2 PCLO PHACTR1	9.36e-05	200	53	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP5 PCLO CCDC80 PALLD	9.36e-05	200	53	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital\|World / Primary Cells by Cluster	NHSL1 ZC2HC1A PCLO EIF4B	9.36e-05	200	53	4	6bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19\|World / Primary Cells by Cluster	NHSL1 ZC2HC1A PCLO EIF4B	9.36e-05	200	53	4	c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	DOCK1 DLGAP2 MYO16	3.47e-04	115	53	3	eae0227fbdffe41656d924d74dc885d7f5d5f73d
ToppCell	LV-03._Atrial_Cardiomyocyte\|LV / Chamber and Cluster_Paper	PRRC2A PALLD PHACTR1	3.93e-04	120	53	3	3b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK2 WDHD1 PCLO	4.64e-04	127	53	3	6b24630978eb0772b4cd3bf59e5bc4390be47619
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NHSL1 FAM184A ZC2HC1A	4.97e-04	130	53	3	0f9d3e6297f48ae14d24ac997d8d3a94f337d4d4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NHSL1 FAM184A ZC2HC1A	4.97e-04	130	53	3	fc68a648161dd314d9ee6612fd039cb12171b8c6
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	XIRP1 SMARCE1 PALLD	6.04e-04	139	53	3	9e2a84d5ed7232b70eadbba754d9ca13f2d50fe9
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAM184A JADE2 TPX2	6.29e-04	141	53	3	c7043f3b024bb16bbc89e33075f5b6ced5cb9185
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NHSL1 STAP2 CCDC80	6.56e-04	143	53	3	36ce6f163fb33141c86288086c354b91853fad25
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	PRAM1 DLGAP3 PHACTR2	7.10e-04	147	53	3	4ba9a86ab7033688a9a2a2dc84c001a49af835b4
ToppCell	Smart-seq2-blood_(Smart-seq2)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLGAP2 DPPA4 STAP2	7.39e-04	149	53	3	e99b7cd3728ce76b365526734c2e7f845b2e62c8
ToppCell	Smart-seq2-blood_(Smart-seq2)-hematologic-hematopoietic_progenitor\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLGAP2 DPPA4 STAP2	7.39e-04	149	53	3	6a28dd4530ed411747fdfe743db138a1b5547ed7
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(II)\|lymph-node_spleen / Manually curated celltypes from each tissue	KSR1 ZNF608 PHACTR1	7.82e-04	152	53	3	4f690aed23338687bdefc47e8a2f3d1fdb2b6447
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FAM184A PHACTR2 ZC2HC1A	7.82e-04	152	53	3	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM184A PHACTR2 ZC2HC1A	7.82e-04	152	53	3	eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHF2 MAP4K3 ZFR2	7.82e-04	152	53	3	ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	FAM184A PCLO FGD1	8.43e-04	156	53	3	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STAP2 CCDC80 UTRN	8.59e-04	157	53	3	921805932f7974d37aed547861d555b07f30aba6
ToppCell	Control-Lymphocyte-T_NK-dnT\|Control / Disease, Lineage and Cell Type	PHACTR2 STAP2 MYO16	8.75e-04	158	53	3	7a2fad6426549d910834debfe5e102fe2ab5976d
ToppCell	COVID-19_Moderate-MAIT\|COVID-19_Moderate / disease group, cell group and cell class	PHACTR2 SETSIP ZFR2	8.91e-04	159	53	3	6d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PHF2 MAP4K3 ZFR2	9.07e-04	160	53	3	19105debef96ea0c267d6a1d332303ec668ae47e
ToppCell	COVID-19_Moderate-MAIT\|World / disease group, cell group and cell class	PHACTR2 SETSIP ZFR2	9.07e-04	160	53	3	bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP3 SHANK2 SRRM2	9.24e-04	161	53	3	d02f8c01b26158a06e109eb603b0fe76372ec983
ToppCell	Control-Treg\|World / Disease group and Cell class	DLGAP3 PHACTR2 ZC2HC1A	9.24e-04	161	53	3	ead9f5a491321f9e307f7c97e47a4ca124f59bb6
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLGAP2 SHANK2 PALLD	9.57e-04	163	53	3	a1fbefe53523a9879a4d4b493071059798b5f917
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	FAM184A SHANK2 PHACTR1	9.57e-04	163	53	3	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	5'-Airway_Nasal_SMG-Epithelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLGAP2 SHANK2 PALLD	9.57e-04	163	53	3	454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLGAP2 SHANK2 PALLD	9.57e-04	163	53	3	d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCell	IIF-Other-HSPC\|IIF / Disease, Lineage and Cell Type	DLGAP2 DPPA4 PCLO	9.57e-04	163	53	3	1e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLGAP2 SHANK2 PALLD	9.57e-04	163	53	3	f6847f47a8856c0d4136c1af317432d45eccfde9
Disease	tauopathy (implicated_via_orthology)	CD2AP SH3KBP1	1.36e-04	10	52	2	DOID:680 (implicated_via_orthology)
Disease	monocyte percentage of leukocytes	KSR1 EPS15L1 ZC2HC1A JADE2 KIF1B TPX2 MYO16	2.83e-04	731	52	7	EFO_0007989
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SET SRRM2	4.07e-04	17	52	2	DOID:0060307 (is_implicated_in)
Disease	multiple sclerosis	EPS15L1 PHACTR2 ZC2HC1A JADE2 KIF1B ASAP1	6.02e-04	594	52	6	MONDO_0005301
Disease	blood pressure	MYO16 PHACTR1	6.88e-04	22	52	2	EFO_0004325
Disease	nephrotic syndrome (implicated_via_orthology)	CD2AP SH3KBP1	8.20e-04	24	52	2	DOID:1184 (implicated_via_orthology)
Disease	lifestyle measurement, depressive symptom measurement	DOCK1 ASAP1 PHACTR1	8.52e-04	105	52	3	EFO_0007006, EFO_0010724
Disease	immature platelet fraction	CD2AP KIF1B ASAP1	1.08e-03	114	52	3	EFO_0009187
Disease	Drug habituation	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0013170
Disease	Substance-Related Disorders	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0236969
Disease	Drug abuse	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0013146
Disease	Drug Use Disorders	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0013222
Disease	Drug Dependence	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C1510472
Disease	Substance Dependence	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0038580
Disease	Substance Use Disorders	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C0029231
Disease	Prescription Drug Abuse	DOCK1 FAM184A BCAR3	1.11e-03	115	52	3	C4316881
Disease	Intellectual Disability	SET SHANK2 PTPN23 SHANK3 PHACTR1	1.13e-03	447	52	5	C3714756
Disease	Substance abuse problem	DOCK1 FAM184A BCAR3	1.14e-03	116	52	3	C0740858
Disease	inflammatory bowel disease	KSR1 DLGAP3 PHACTR2 ZC3H13 PRRC2A	1.15e-03	449	52	5	EFO_0003767
Disease	irritable bowel syndrome	PHF2 PCLO PRRC2A	1.61e-03	131	52	3	EFO_0000555
Disease	mean platelet volume	SET CD2AP KIF1B SH3KBP1 STIP1 SHANK3 ASAP1	1.99e-03	1020	52	7	EFO_0004584
Disease	fibromuscular dysplasia	FAM184A PHACTR1	2.75e-03	44	52	2	EFO_1000938
Disease	adipose tissue measurement	DOCK1 MYO16	2.87e-03	45	52	2	EFO_0004764
Disease	grip strength measurement	JADE2 KIF1B PRRC2A PHACTR1	3.36e-03	350	52	4	EFO_0006941
Disease	platelet-to-lymphocyte ratio	EPS15L1 KIF1B TPX2 TNKS1BP1	3.83e-03	363	52	4	EFO_0008446
Disease	health literacy measurement	DLGAP2 ZFR2	3.96e-03	53	52	2	EFO_0010104
Disease	phenylalanine measurement	WDHD1 CLDN23	4.26e-03	55	52	2	EFO_0005001
Disease	health study participation	PHF2 JADE2 PRRC2A	4.95e-03	195	52	3	EFO_0010130

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPALPPKKPAPPRPK	EPS15L1	776	Q9UBC2
PKKPAPPRPKPPSGK	EPS15L1	781	Q9UBC2
PKPPPKPCKVPFLKV	BCAR3	401	O75815
QKKIPIPPLPSKLPP	DPPA4	76	Q7L190
KVPPPIPKKPPKGKF	DLGAP2	986	Q9P1A6
KRPEKPVPPPPPIAK	CD2AP	411	Q9Y5K6
SSKPLPQPVPPKGPK	FAM184A	1096	Q8NB25
VPGPPKPAKEKPPKK	CCDC80	481	Q76M96
ELKKKPPPRPTAPKP	PTPN23	711	Q9H3S7
TLKAKIPPPLPPKPK	MAP4K3	426	Q8IVH8
VPPPPPCKKPSLLKK	MYO16	1826	Q9Y6X6
KNLVPKPVPPPSKPN	GPBP1L1	236	Q9HC44
PPPMPLSKPVPATKL	KIF1B	1221	O60333
KPAPPKPEPKPKKAP	HMGN2	31	P05204
GRTRLPAKKKPPPPP	JADE2	596	Q9NQC1
PPPISKKPKLFLVVP	NHSL1	1196	Q5SYE7
KAPEPKKPPPLVKQP	PCLO	696	Q9Y6V0
TKLKPPRTPPPPSRK	KSR1	281	Q8IVT5
PKPRPKPKPKKSPVP	PHACTR2	161	O75167
CLPVKLSPPLPPKKV	PHACTR1	231	Q9C0D0
PPPLLAKPKLDPLKL	PALLD	646	Q8WX93
PPPPPIVKKPLKQGG	MYO15B	1026	Q96JP2
KPPALKNPPKFAPLP	CEFIP	166	Q711Q0
EPKPKPQLKPKPPVA	HS1BP3	321	Q53T59
PSKTPPPPPPKTTRK	DOCK1	1841	Q14185
PKEEKKVPPPIPKKP	DLGAP3	906	O95886
TLSKKRPPPPPPGHK	ASAP1	821	Q9ULH1
PPPAQHRKPKPKPKV	CLDN23	231	Q96B33
KPDQPLKVMPAPPPK	EIF4B	466	P23588
KSKQELPPPPPPKKR	UTRN	666	P46939
LPKPPAKLPKPPVGP	STAP2	341	Q9UGK3
AKLPKPPVGPKPEPK	STAP2	346	Q9UGK3
PQALPKPASPKKPPP	SRRM2	2656	Q9UQ35
PPKPPRPPKTLKLKD	PHF2	511	O75151
IATPPPPPPPKKETK	STIP1	196	P31948
GITIPKPPKPPDKPL	SMARCE1	56	Q969G3
LKRAPGPKPQVPPKP	FGD1	151	P98174
KKPPPPEVTDLPKKP	PRAM1	81	Q96QH2
LPKKPPPPEVTDLPK	PRAM1	91	Q96QH2
RPKKPPPPSAPVIKQ	SH3KBP1	336	Q96B97
QKPSVPAIPPKKPRP	SH3KBP1	391	Q96B97
PAIPPKKPRPPKTNS	SH3KBP1	396	Q96B97
PRRAGPIKKPPPPTK	PRRC2A	946	P48634
PIKKPPPPTKVEELP	PRRC2A	951	P48634
KPPTGPLPPSKEPLK	PRRC2A	1196	P48634
QSPLPLQKKKPRPPP	SETSIP	16	P0DME0
QSPLPPQKKKPRPPP	SET	6	Q01105
PQKKKPRPPPALGPE	SET	11	Q01105
VPPPIKPKPVVPKTN	ARHGAP5	1036	Q13017
VDKPPVPPKPKMKPI	SHANK2	1541	Q9UPX8
KPPLPSKLPRPKAGP	ZFR2	251	Q9UPR6
LLEKPPVPPKPKLKS	SHANK3	1406	Q9BYB0
PVPPKPKLKSPLGKG	SHANK3	1411	Q9BYB0
PPKPKPPPLTKETVV	TMIE	36	Q8NEW7
EKSPIIKPLIPKPKP	WDHD1	956	O75717
KKPPPVPALPSKLPT	TRIM25	391	Q14258
KVPGLGKPLTLPPKP	TNKS1BP1	1691	Q9C0C2
IPTVKPLKPRPEPPK	ZC2HC1A	61	Q96GY0
KSPPLKPIQPKPTIM	ZNF608	781	Q9ULD9
PAKPLISVPCKPLKP	ZMYM1	271	Q5SVZ6
PTMPPKKKPQLPPKP	XIRP1	1316	Q702N8
SKKKGPRTPSPPPPI	ZC3H13	256	Q5T200
PILPKKPPVKPPTEP	TPX2	416	Q9ULW0
PKKSPKAPPPVARKP	KIAA1522	956	Q9P206