Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpolysaccharide binding

CLEC18A CLEC18B PTX3 CLEC18C

3.01e-0631654GO:0030247
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

3.12e-053652GO:0018858
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

6.23e-054652GO:0102391
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM2A ACSM2B

2.88e-048652GO:0004321
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM2A ACSM2B

5.63e-0411652GO:0031956
GeneOntologyCellularComponentRAVE complex

DMXL2 DMXL1

2.94e-053662GO:0043291
DomainRav1p_C

DMXL2 DMXL1

1.16e-052642IPR022033
DomainRav1p_C

DMXL2 DMXL1

1.16e-052642PF12234
Domain-

CLEC18A CLEC18B CLEC18C

1.70e-05156433.40.33.10
DomainCAP

CLEC18A CLEC18B CLEC18C

1.70e-0515643PF00188
DomainCAP_domain

CLEC18A CLEC18B CLEC18C

1.70e-0515643IPR014044
DomainSCP

CLEC18A CLEC18B CLEC18C

1.70e-0515643SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C

1.70e-0515643IPR001283
DomainDUF846_euk

TVP23C TVP23B

6.90e-054642IPR008564
DomainDUF846

TVP23C TVP23B

6.90e-054642PF05832
DomainC-type_lectin_CS

CLEC18A CLEC18B CLEC18C

4.29e-0443643IPR018378
DomainAMP-bd_C

ACSM2A ACSM2B

1.52e-0317642IPR025110
DomainAMP-binding_C

ACSM2A ACSM2B

1.52e-0317642PF13193
DomainC_TYPE_LECTIN_1

CLEC18A CLEC18B CLEC18C

2.61e-0380643PS00615
DomainLectin_C

CLEC18A CLEC18B CLEC18C

3.00e-0384643PF00059
DomainCLECT

CLEC18A CLEC18B CLEC18C

3.00e-0384643SM00034
DomainC_TYPE_LECTIN_2

CLEC18A CLEC18B CLEC18C

3.10e-0385643PS50041
DomainC-type_lectin-like

CLEC18A CLEC18B CLEC18C

3.21e-0386643IPR001304
DomainAMP-binding_CS

ACSM2A ACSM2B

3.56e-0326642IPR020845
DomainAMP_BINDING

ACSM2A ACSM2B

4.13e-0328642PS00455
DomainHRM

ADGRA2 PTH2R

4.13e-0328642PF02793
Domain-

CLEC18A CLEC18B CLEC18C

4.50e-03976433.10.100.10
DomainAMP-binding

ACSM2A ACSM2B

4.73e-0330642PF00501
DomainAMP-dep_Synth/Lig

ACSM2A ACSM2B

4.73e-0330642IPR000873
DomainC-type_lectin-like/link

CLEC18A CLEC18B CLEC18C

4.76e-0399643IPR016186
DomainCTDL_fold

CLEC18A CLEC18B CLEC18C

5.91e-03107643IPR016187
DomainGPCR_2_secretin-like_CS

ADGRA2 PTH2R

6.04e-0334642IPR017983
DomainG_PROTEIN_RECEP_F2_1

ADGRA2 PTH2R

8.29e-0340642PS00649
DomainGPCR_2_extracellular_dom

ADGRA2 PTH2R

8.29e-0340642IPR001879
DomainG_PROTEIN_RECEP_F2_3

ADGRA2 PTH2R

8.29e-0340642PS50227
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

6.83e-09367326170455
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

6.83e-09367316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

6.83e-09367333603190
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

2.73e-08467316709836
Pubmed

Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.

ACSM2A ACSM2B

3.66e-06267219634011
Pubmed

The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.

ACSM2A ACSM2B

3.66e-06267216521160
Pubmed

Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.

ACSM2A ACSM2B

3.66e-06267229948332
Pubmed

Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.

ACSM2A ACSM2B

2.19e-05467232830538
Pubmed

Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.

CLEC18A CLEC18B CLEC18C

5.07e-053767322432025
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

PKMYT1 NPC1 DMXL2 EMC1 GLE1 VPS13B DMXL1

5.29e-0550467734432599
Pubmed

The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.

RASA1 SPSB1

5.46e-05667215713673
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

NDUFAF2 PDK2 GTPBP3 ACSM2A SLC25A23 NDUFS3 TEFM MLYCD PPOX ACSM2B

6.08e-051136671034800366
Pubmed

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.

NPC1 NAGLU

1.30e-04967215647513
Pubmed

Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries.

CTSC PPOX

1.63e-041067210756096
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

DMXL2 OTUD7A CHD4 TEFM

1.91e-0414767429576527
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

NPC1 EMC1 CTSC NAGLU

2.90e-0416467432409323
Pubmed

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

TYR RASA1

3.28e-04146728114702
Pubmed

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.

TYR RASA1

3.28e-04146721354647
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

DMXL2 PTX3 CHD4 TVP23B NEB

3.98e-0432267526514267
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

NDUFAF2 PDK2 GTPBP3 ACSM2A SLC25A23 NDUFS3 MLYCD PPOX

3.99e-0492667820877624
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

CLEC18A TNFRSF25 CLEC18B CLDN17 TMPRSS3 LYZL6 LYPD3 CES4A

5.99e-0498567812975309
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

PDK2 GTPBP3 ACSM2A SLC25A23 NDUFS3 MLYCD PPOX ACSM2B

8.90e-04104767818614015
Pubmed

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

ACSM2A ACSM2B

1.07e-032567219372376
Pubmed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.

NDUFAF2 PDK2 NDUFS3 MLYCD PPOX

1.22e-0341367527499296
Pubmed

Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.

DMXL2 DMXL1

1.24e-032767226442671
Pubmed

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

RASA1 NEB

1.34e-032867218067320
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

PRMT6 B4GAT1 PARP2 CHD4

1.36e-0324867427926873
Pubmed

Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors.

RASA1 SPTB

1.44e-03296727789972
Pubmed

Nuclear Gene-Encoded Leigh Syndrome Spectrum Overview

NDUFAF2 NDUFS3

1.54e-033067226425749
Pubmed

Defining the membrane proteome of NK cells.

PKMYT1 NPC1 MAN1A2 GLE1 ARFGAP3 CTSC CHD4 CYBA

1.78e-03116867819946888
Cytoband16q24

MLYCD CYBA

2.81e-041767216q24
Cytoband16q22.1

CLEC18A CLEC18C CES4A

5.73e-0411067316q22.1
Cytoband16p12.3

ACSM2A ACSM2B

1.14e-033467216p12.3
CytobandEnsembl 112 genes in cytogenetic band chr16q22

CLEC18A CLEC18C CES4A

2.47e-03183673chr16q22
GeneFamilyC-type lectin domain family

CLEC18A CLEC18B CLEC18C

1.52e-0447403494
GeneFamilyAcyl-CoA synthetase family

ACSM2A ACSM2B

1.50e-032640240
CoexpressionGSE19401_PAM2CSK4_VS_RETINOIC_ACID_AND_PAM2CSK4_STIM_FOLLICULAR_DC_UP

TYR RASA1 PDK2 SLC20A2 SPSB1 PTH2R

1.07e-05198666M7673
CoexpressionDESCARTES_ORGANOGENESIS_MELANOCYTES

TYR CLEC18A CLEC18B CLEC18C

2.35e-0566664MM3664
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

CLEC18A CLEC18B ACSM2A PTH2R ACSM2B

3.02e-06151665e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellfacs-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTX3 LYPD3 ALDH3B2 ACSM2B CYBA

7.11e-0618066572310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCell10x5'v1-week_17-19-Lymphocytic_T-T_NK-NK_T_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TNFRSF25 SLC20A2 LYPD3 CES4A SLC25A23

8.55e-061876653301e0fca8c436d136c71f1a8fd59b3bb11bdd83
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPC1 DMXL2 ARFGAP3 PTX3 CD300E

9.48e-061916650b296404ebad0aadb75737f8c0462ec6934fc8bb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 ARFGAP3 PTX3 SPSB1 CD300E

9.72e-061926658b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell390C-Myeloid-Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DMXL2 PTX3 CTSC CD300E CYBA

1.13e-0519866536e49a4860b37d674511120b9e0366efa1e08480
DrugAC1L3LTR

TYR CTSC TMPRSS3 PPOX

1.01e-0627654CID000142774
DrugCyclodextrins

TYR MB PPOX

7.90e-0614653CID000024238
DrugGly-Leu-Tyr

TYR MB

8.03e-062652CID000096817
Drug3-fluorophenol

TYR MB

8.03e-062652CID000009743
Drug3-(trimethylsilyl)propanesulfonic acid

MB PPOX

8.03e-062652CID000074873
Drugpropyltrimethylammonium bromide

TYR PPOX

8.03e-062652CID000029384
DrugN,N'-di-tert-butylethylenediamine

TYR PPOX

8.03e-062652CID000077680
Drug2,6-dimethylphenol

TYR CTSC PPOX

1.21e-0516653CID000011335
DrugClozapine [5786-21-0]; Up 200; 12.2uM; PC3; HT_HG-U133A

TNFRSF25 GLE1 SPTB SMPD2 NEB ADGRA2

1.87e-051936564670_UP
Drugdiamino sulfate

TYR B4GAT1 CTSC NAGLU GTPBP3 PPOX

1.87e-05193656CID006327663
DrugSpironolactone [52-01-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A

TNFRSF25 MAN1A2 EMC1 SPTB VPS13B PTH2R

2.16e-051986562226_UP
DrugGly-His

TYR CTSC PPOX

3.78e-0523653CID000417360
DrugAC1NUTWC

ACSM2A ACSM2B

4.80e-054652CID005460914
Drugchrome azurol

TYR PPOX

4.80e-054652CID000468205
Drug2,6-nonadienal

TYR PPOX

4.80e-054652CID000011196
Drugdiethyl phthalate

TYR CTSC MB

5.51e-0526653CID000006781
DrugTyr-Gly

TYR SLC15A2 CTSC

6.19e-0527653CID000259323
Drugacetic acids

TYR ACSM2A ACSM2B

6.91e-0528653CID000031229
DiseaseX-21319 measurement

ACSM2A ACSM2B

4.63e-062642EFO_0800807
DiseaseX-11478 measurement

ACSM2A ACSM2B

1.39e-053642EFO_0021242
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

4.61e-055642EFO_0800378
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

6.91e-056642EFO_0800106
DiseaseCognitive impairment

PTPRT DMXL1

2.52e-0411642HP_0100543
Diseasebeta-hydroxyisovalerate measurement

TNFRSF25 ACSM2B

4.14e-0414642EFO_0800125
Diseasesunburn

TYR CTSC CYBA

1.20e-0396643EFO_0003958
DiseasePigmented Basal Cell Carcinoma

TYR RASA1

1.69e-0328642C1368275
DiseaseCarcinoma, Basal Cell

TYR RASA1

1.81e-0329642C4721806
DiseaseMITOCHONDRIAL COMPLEX I DEFICIENCY

NDUFAF2 NDUFS3

1.94e-0330642C1838979

Protein segments in the cluster

PeptideGeneStartEntry
WSWFQLRCMQVGGNA

ARFGAP3

71

Q9NP61
LWRGLREMLDQSNQW

B4GAT1

236

O43505
AMWACGALAVSQRWL

ADGRA2

1031

Q96PE1
AGWTGLQASDIMWTI

ACSM2A

246

Q08AH3
LSMLGAVFWVNRPQW

CD300E

186

Q496F6
MWRGLWTLAAQAARG

GTPBP3

1

Q969Y2
GWRWLAQILNMEPLS

GLE1

601

Q53GS7
RAMGIGWWVRNINTL

DMXL2

1631

Q8TDJ6
TDWNQQLLRWGMGSQ

ALDH3B2

366

P48448
TGQMLGRTLSRWVWI

ATP4B

26

P51164
SELRAMGVGWWVRNT

DMXL1

1601

Q9Y485
RGWRGLAALWMLLAQ

ADAMTS16

6

Q8TE57
WMALNGINLALAWSG

NAGLU

156

P54802
LWEGLWMNCIRQARV

CLDN17

46

P56750
GWMWVTNLRTDEQGL

RASA1

316

P20936
AQRNFSVWMRWGRVG

PARP2

141

Q9UGN5
LWHGSRMSNWVGILS

PARP2

426

Q9UGN5
IVSGARGMNNWVEWR

LYZL6

116

O75951
IQAWWRGTMVQRGFG

LRRIQ4

511

A6NIV6
NGAVLWRINWMADVS

MLYCD

426

O95822
WRINWMADVSLRGIT

MLYCD

431

O95822
WAMWANEQALASGLI

CYBA

6

P13498
RGNWGLLDQMAALRW

CES4A

186

Q5XG92
QVIWGMSWAKLARQA

FBXO39

266

Q8N4B4
TMVALEQAGRLNWWS

OTUD7A

176

Q8TE49
WTEWRILNMSSGIVN

GPR52

6

Q9Y2T5
KAGAQAMIWTAGWLL

LYPD3

6

O95274
MRWVWALLKNASLAG

PDK2

1

Q15119
WLQQWNGRDTALMVT

PTPRT

226

O14522
VMWLWGISLNAVSLV

NPC1

1141

O15118
TELGLGMAQARWWAT

SMPD2

311

O60906
GSIGRLLEWMIRWSN

CPLANE1

1741

Q9H799
TMTGWVHDVLGRNWA

CTSC

121

P53634
ISDQMLEWRLGFWSQ

PRMT6

196

Q96LA8
WLMWKAQGDQGLERR

CSAD

366

Q9Y600
AMVNLKSGVGRNWGW

MAN1A2

311

O60476
IMRSWETNIGGLNWE

EMC1

106

Q8N766
MEGLNWLRFSWAQGT

CHD4

731

Q14839
MFWALLDQQGSRWTL

SLC15A2

311

Q16348
TGLWVWGRRVIQTMG

SLC20A2

546

Q08357
MVSLGRWTHLCGTWN

PTX3

261

P26022
MSERVERNWSTGGWL

TAFA3

1

Q7Z5A8
SRVWQGTMEKAGLAW

ITPKB

506

P27987
MAAAAVARLWWRGIL

NDUFS3

1

O75489
VLDWQQSDRWSLMRG

TEFM

191

Q96QE5
WGRDLLQQWGAEITM

ERVK-9

871

P63128
AGWTGLQASDIMWTI

ACSM2B

246

Q68CK6
LASGLWRTLQVGWNM

CLEC18A

96

A5D8T8
LASGLWRTLQVGWNM

CLEC18B

96

Q6UXF7
LASGLWRTLQVGWNM

CLEC18C

96

Q8NCF0
RIVGGNMSLLSQWPW

TMPRSS3

216

P57727
AERWSQWSLRGGLEM

PPOX

221

P50336
NVTGRLMVGLRWWNH

TVP23C

81

Q96ET8
LGSAVTMLTGNWRWA

SPNS3

191

Q6ZMD2
MAAEALSRGWALWQA

PKMYT1

371

Q99640
GLHVWQITWAMRQRG

SPSB1

96

Q96BD6
WNRRAVNICGMHGWT

SPART-AS1

16

P0CW21
ASRIWSWLLGAAMVG

TYR

471

P14679
MGWSQDLFRALWRSL

NDUFAF2

1

Q8N183
EMAVNLWNWALTIGG

TEX11

71

Q8IYF3
LDTGWNALGRMWESR

SPTB

1146

P11277
GWRQMFWVQVLLAGL

TNFRSF25

196

Q93038
WGWLMLGSCLLARAQ

PTH2R

11

P49190
MGLSDGEWQLVLNVW

MB

1

P02144
GGTSGRVSLWMQWVL

VPS13B

1316

Q7Z7G8
LTGMWWKQLVAGAVA

SLC25A23

181

Q9BV35
NVTGRLMVGLRWWNH

TVP23B

81

Q9NYZ1
VSWWGSTLAMLQRLK

ZBED1

351

O96006
DLQWMRGIGWVSIGS

NEB

2901

P20929