Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX16 ATP5PB MYH3 MYO1E CFTR AK6 CHD8 SMC5 ATAD2B RECQL4 HFM1 CHD6

1.06e-0444114712GO:0016887
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

1.54e-04371474GO:0061631
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

2.78e-04431474GO:0061650
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ARHGAP24 DOCK11 RAPGEF5 TBC1D2B PREX2 RCC1L ASAP2 RALGPS1 RASGEF1B RIMS1 ALDH1A1 ACAP2

3.80e-0450714712GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

ARHGAP24 DOCK11 RAPGEF5 TBC1D2B PREX2 RCC1L ASAP2 RALGPS1 RASGEF1B RIMS1 ALDH1A1 ACAP2

3.80e-0450714712GO:0030695
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor activity

HTR1F CHRM5 HRH2

5.43e-04221473GO:0004993
GeneOntologyMolecularFunctionnucleoside monophosphate kinase activity

AK6 AK5 DLG1

6.21e-04231473GO:0050145
GeneOntologyMolecularFunctionATP-dependent activity

DHX16 ATP5PB MYH3 MYO1E CFTR AK6 CHD8 ZNFX1 SMC5 ATAD2B RECQL4 HFM1 CHD6

6.24e-0461414713GO:0140657
GeneOntologyBiologicalProcessdigestive tract development

TIGAR CDX2 TCF7L2 CHD8 CCDC39 HOXA5 NPHP3 HRH2

1.36e-051521478GO:0048565
GeneOntologyBiologicalProcessepithelium development

KRT72 KRAS TIGAR DLG5 CDX1 CDX2 TCF7L2 ARHGAP24 MYO1E KRT74 CFTR SHANK3 CCDC39 HOXA5 NCOR2 GRHL1 NPHP3 PBRM1 ALMS1 KRT71 BRCA2 PCDH15 HRH2 DLG1 ALDH1A1 ALDH1A3

1.41e-05146914726GO:0060429
GeneOntologyBiologicalProcessdigestive system development

TIGAR CDX2 TCF7L2 CHD8 CCDC39 HOXA5 NPHP3 HRH2

2.68e-051671478GO:0055123
GeneOntologyBiologicalProcessanimal organ morphogenesis

KRAS DLG5 CDX1 CDX2 TCF7L2 CDX4 CFTR NAB2 SHANK3 CCDC39 CASZ1 ITPR1 HOXA5 NCOR2 NPHP3 SULF2 PBRM1 ALMS1 RECQL4 PCDH15 DLG1 ALDH1A1 ALDH1A3

3.28e-05126914723GO:0009887
GeneOntologyBiologicalProcessembryo development

GDF5 MYH3 CDX1 CDX2 TCF7L2 CDX4 MYO1E CAPN2 LMBR1 CHD8 NIBAN2 PAF1 SHANK3 CCDC39 HOXA5 NCOR2 NPHP3 SULF2 PBRM1 BRCA2 PCDH15 DLG1 ALDH1A1 ALDH1A3

7.93e-05143714724GO:0009790
GeneOntologyBiologicalProcessprotein K29-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4

9.63e-05131473GO:0035519
DomainCaudal_act

CDX1 CDX2 CDX4

4.98e-0731493PF04731
DomainCaudal_activation_dom

CDX1 CDX2 CDX4

4.98e-0731493IPR006820
DomainP-loop_NTPase

DHX16 KRAS MYH3 DLG5 MYO1E CFTR AK6 CHD8 ZNFX1 SMC5 NPHP3 AK5 ATAD2B RECQL4 ASPM DLG1 HFM1 CHD6

1.46e-0484814918IPR027417
DomainDNA/RNA_helicase_DEAH_CS

DHX16 CHD8 RECQL4 CHD6

1.68e-04351494IPR002464
DomainFerA

DYSF MYOF

1.89e-0431492SM01200
DomainFerlin_A-domain

DYSF MYOF

1.89e-0431492IPR012560
DomainFerA

DYSF MYOF

1.89e-0431492PF08165
DomainDEAH_ATP_HELICASE

DHX16 CHD8 RECQL4 CHD6

2.33e-04381494PS00690
DomainUQ_con

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

2.58e-04391494PF00179
DomainUBIQUITIN_CONJUGAT_1

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

2.84e-04401494PS00183
Domain-

DHX16 KRAS DLG5 MYO1E CFTR AK6 CHD8 ZNFX1 SMC5 NPHP3 AK5 ATAD2B RECQL4 DLG1 HFM1 CHD6

3.11e-04746149163.40.50.300
DomainUBIQUITIN_CONJUGAT_2

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

3.13e-04411494PS50127
DomainUBQ-conjugat_E2

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

3.13e-04411494IPR000608
DomainDysFC

DYSF MYOF

3.75e-0441492SM00694
DomainDysFN

DYSF MYOF

3.75e-0441492SM00693
DomainPeroxin/Ferlin

DYSF MYOF

3.75e-0441492IPR006614
DomainFerI

DYSF MYOF

6.22e-0451492SM01202
DomainFerB

DYSF MYOF

6.22e-0451492SM01201
DomainFerlin_B-domain

DYSF MYOF

6.22e-0451492IPR012561
DomainFerlin_C

DYSF MYOF

6.22e-0451492PF16165
DomainFerlin_C

DYSF MYOF

6.22e-0451492IPR032362
DomainFerIin_dom

DYSF MYOF

6.22e-0451492IPR012968
DomainFerI

DYSF MYOF

6.22e-0451492PF08151
DomainFerB

DYSF MYOF

6.22e-0451492PF08150
Domain-

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

7.27e-045114943.10.110.10
DomainUBQ-conjugating_enzyme/RWD

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

8.41e-04531494IPR016135
DomainKeratin_2_head

KRT72 KRT74 KRT71

8.91e-04241493IPR032444
DomainKeratin_2_head

KRT72 KRT74 KRT71

8.91e-04241493PF16208
DomainBRK

CHD8 CHD6

9.29e-0461492SM00592
DomainBRK_domain

CHD8 CHD6

9.29e-0461492IPR006576
DomainBRK

CHD8 CHD6

9.29e-0461492PF07533
DomainUBQ-conjugating_AS

UBE2D2 UBE2D3 UBE2D4

1.01e-03251493IPR023313
DomainRASGEF

RAPGEF5 RALGPS1 RASGEF1B

1.13e-03261493PS00720
DomainKeratin_II

KRT72 KRT74 KRT71

1.13e-03261493IPR003054
DomainRASGEF_CAT

RAPGEF5 RALGPS1 RASGEF1B

1.56e-03291493PS50009
DomainHelicase_C

DHX16 CHD8 RECQL4 HFM1 CHD6

1.67e-031071495PF00271
DomainHELICc

DHX16 CHD8 RECQL4 HFM1 CHD6

1.67e-031071495SM00490
DomainRasGEF

RAPGEF5 RALGPS1 RASGEF1B

1.73e-03301493PF00617
Domain-

RAPGEF5 RALGPS1 RASGEF1B

1.73e-033014931.10.840.10
DomainRASGEF_cat_dom

RAPGEF5 RALGPS1 RASGEF1B

1.73e-03301493IPR001895
DomainRasGEF

RAPGEF5 RALGPS1 RASGEF1B

1.73e-03301493SM00147
DomainRas_GEF_dom

RAPGEF5 RALGPS1 RASGEF1B

1.73e-03301493IPR023578
DomainHelicase_C

DHX16 CHD8 RECQL4 HFM1 CHD6

1.74e-031081495IPR001650
DomainSH3

DLG5 NEBL MYO1E SHANK3 ASAP2 ZDHHC6 DLG1

1.76e-032161497SM00326
DomainPH

ARHGAP24 DOCK11 TBC1D2B NIBAN2 PREX2 ASAP2 RALGPS1 ACAP2

1.78e-032781498SM00233
DomainHELICASE_CTER

DHX16 CHD8 RECQL4 HFM1 CHD6

1.81e-031091495PS51194
DomainHELICASE_ATP_BIND_1

DHX16 CHD8 RECQL4 HFM1 CHD6

1.81e-031091495PS51192
DomainDEXDc

DHX16 CHD8 RECQL4 HFM1 CHD6

1.81e-031091495SM00487
DomainPH_DOMAIN

ARHGAP24 DOCK11 TBC1D2B NIBAN2 PREX2 ASAP2 RALGPS1 ACAP2

1.82e-032791498PS50003
DomainPH_domain

ARHGAP24 DOCK11 TBC1D2B NIBAN2 PREX2 ASAP2 RALGPS1 ACAP2

1.86e-032801498IPR001849
DomainHelicase_ATP-bd

DHX16 CHD8 RECQL4 HFM1 CHD6

1.89e-031101495IPR014001
DomainSH3_domain

DLG5 NEBL MYO1E SHANK3 ASAP2 ZDHHC6 DLG1

1.95e-032201497IPR001452
DomainPH

ARHGAP24 DOCK11 TBC1D2B PREX2 ASAP2 RALGPS1 ACAP2

2.45e-032291497PF00169
DomainFilament

KRT72 IFFO1 KRT74 KRT71

2.50e-03711494SM01391
DomainBROMODOMAIN_1

BRWD3 PBRM1 ATAD2B

3.17e-03371493PS00633
DomainIF

KRT72 IFFO1 KRT74 KRT71

3.20e-03761494IPR001664
DomainBromodomain

BRWD3 PBRM1 ATAD2B

3.42e-03381493PF00439
DomainBROMODOMAIN_2

BRWD3 PBRM1 ATAD2B

4.25e-03411493PS50014
DomainBromodomain

BRWD3 PBRM1 ATAD2B

4.55e-03421493IPR001487
DomainBROMO

BRWD3 PBRM1 ATAD2B

4.55e-03421493SM00297
Domain-

BRWD3 PBRM1 ATAD2B

4.55e-034214931.20.920.10
DomainRas_G-nucl-exch_fac_CS

RAPGEF5 RASGEF1B

5.40e-03141492IPR019804
DomainPDZ

DLG5 SHANK3 PREX2 DLG1 RIMS1

5.48e-031411495PF00595
DomainHomeobox_metazoa

CDX1 CDX2 CDX4 HOXA5

5.85e-03901494IPR020479
DomainPDZ

DLG5 SHANK3 PREX2 DLG1 RIMS1

6.71e-031481495SM00228
DomainAld_DH_CS_GLU

ALDH1A1 ALDH1A3

7.05e-03161492IPR029510
Domain-

DLG5 SHANK3 PREX2 DLG1 RIMS1

7.09e-0315014952.30.42.10
DomainPDZ

DLG5 SHANK3 PREX2 DLG1 RIMS1

7.29e-031511495PS50106
DomainPDZ

DLG5 SHANK3 PREX2 DLG1 RIMS1

7.49e-031521495IPR001478
DomainAnk_2

SHANK3 ANKRD36B ASAP2 ANKRD36 ACAP2 SOWAHB

7.64e-032151496PF12796
DomainSH3

DLG5 NEBL MYO1E SHANK3 ASAP2 DLG1

7.80e-032161496PS50002
DomainAld_DH_CS_CYS

ALDH1A1 ALDH1A3

7.95e-03171492IPR016160
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ATP5PB KRT72 MYH3 KRT74 TM9SF3 COQ6 UTP14A KRBA2 DNAJC7 OGDH CYB5B SNRNP48 KRT71 PIP4K2A UNC5C ASPM TENM1 DLG1 CHD6 EIF3A RIMS1 ALDH1A1 TMCO1

6.37e-0814421502335575683
Pubmed

Cdx4 is a Cdx2 target gene.

CDX1 CDX2 CDX4

7.86e-083150320933081
Pubmed

Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.

CDX1 CDX2 CDX4

7.86e-083150318511567
Pubmed

[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia].

CDX1 CDX2 CDX4

7.86e-083150321518475
Pubmed

Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos.

CDX1 CDX2 CDX4

7.86e-083150311500978
Pubmed

Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.

CDX1 CDX2 CDX4

7.86e-083150318252864
Pubmed

cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse.

CDX1 CDX2 CDX4

7.86e-083150316281167
Pubmed

K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.

KRT72 KRT74 KRT71

3.14e-074150312648212
Pubmed

Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice.

CDX1 CDX2 CDX4

3.14e-074150318579683
Pubmed

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.

CDX1 CDX2 CDX4

3.14e-074150330343898
Pubmed

Cdx1 and Cdx2 are functionally equivalent in vertebral patterning.

CDX1 CDX2 CDX4

7.81e-075150319328777
Pubmed

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

1.23e-0619150427425610
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

DLG5 TTLL5 UTP14A TBC1D2B NCOR2 ALMS1 SVIL PIBF1

1.46e-06184150832908313
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KIAA0930 UTP14A ZFP28 SHANK3 CASZ1 MYOF ASAP2 NPHP3 ALMS1 CNTNAP4 EIF3A SSH2

1.70e-064931501215368895
Pubmed

Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence.

CDX1 CDX2 CDX4 HOXA5

1.88e-0621150422675207
Pubmed

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

UBE2D2 UBE2D3 UBE2D4

2.72e-067150321685362
Pubmed

Developmental regulation of the Hox genes during axial morphogenesis in the mouse.

CDX1 CDX2 CDX4

2.72e-067150315944185
Pubmed

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.

UBE2D2 UBE2D3 UBE2D4

2.72e-067150330884854
Pubmed

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.

CDX1 CDX2 CDX4 HOXA5

2.76e-0623150428041967
Pubmed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

2.76e-0623150430017913
Pubmed

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

UBE2D2 UBE2D3 UBE2D4

4.33e-068150323560854
Pubmed

Role of Cdx factors in early mesodermal fate decisions.

CDX1 CDX2 CDX4

4.33e-068150330936115
Pubmed

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

UBE2D2 UBE2D3 UBE2D4

4.33e-068150328681414
Pubmed

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.

UBE2D2 UBE2D3 UBE2D4

4.33e-068150329323787
Pubmed

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

4.62e-0626150420061386
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

ATP5PB SNX3 NAB2 TM9SF3 FASTKD1 PPIL4 CHD8 OGDH ITPR1 GGH CYB5B CRNKL1 NCOR2 KARS1 TXNDC5 PIP4K2A UNC5C EMD TMCO1 RPL5

4.64e-0614511502030550785
Pubmed

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

5.40e-0627150430097011
Pubmed

Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets.

CDX1 CDX2 CDX4

6.48e-069150315888377
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

TDRD15 CCDC168 NCOR2 UBE2D3 ZER1 ACAP2 SOWAHB

8.92e-06168150730631154
Pubmed

Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.

UBE2D2 UBE2D3 UBE2Q2

9.23e-0610150333607208
Pubmed

Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.

UBE2D2 UBE2D3 UBE2D4

9.23e-0610150331087003
Pubmed

Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.

UBE2D2 UBE2D3 UBE2D4

9.23e-0610150328757353
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

SNX17 MPZL1 NIBAN2 PAF1 DNAJC7 ITPR1 NCOR2 KARS1 TXNDC5 MTUS1 SVIL DLG1 SSH2 EMD PIBF1 PLK1

1.31e-0510491501627880917
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

DLG5 TCF7L2 NEBL TM9SF3 ZNF248 MYOF SVIL PIP4K2A PCDH15 EIF3A

1.39e-054151501016385451
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DHX16 SNX3 TM9SF3 UTP14A AK6 CHD8 PAF1 CRNKL1 RCC1L KARS1 PBRM1 UBE2D3 PIP4K2A CHD6 EIF3A EMD PLK1 RPL5

1.63e-0513181501830463901
Pubmed

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

UBE2D2 UBE2D3 UBE2D4

1.68e-0512150324211586
Pubmed

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.

CDX1 CDX2 CDX4

1.68e-0512150311335109
Pubmed

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

CDX1 CDX2

1.85e-052150218187048
Pubmed

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

ASPM PLK1

1.85e-052150211283617
Pubmed

Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.

ITPR1 PLK1

1.85e-052150218621368
Pubmed

Differential gene expression in normal esophagus and Barrett's esophagus.

CDX1 CDX2

1.85e-052150219468668
Pubmed

HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway.

TXNDC5 KCNH2

1.85e-052150231331361
Pubmed

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression.

BRCA2 PLK1

1.85e-052150214647413
Pubmed

Aldehyde dehydrogenase 1A1 and 1A3 isoforms - mechanism of activation and regulation in cancer.

ALDH1A1 ALDH1A3

1.85e-052150234428540
Pubmed

Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.

KCNV2 KCNH2

1.85e-052150218708743
Pubmed

CHD6 regulates the topological arrangement of the CFTR locus.

CFTR CHD6

1.85e-052150225631877
Pubmed

Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression.

KRAS PAF1

1.85e-052150237572321
Pubmed

Nonsyndromic Early-Onset Cone-Rod Dystrophy and Limb-Girdle Muscular Dystrophy in a Consanguineous Israeli Family are Caused by Two Independent yet Linked Mutations in ALMS1 and DYSF.

DYSF ALMS1

1.85e-052150226077327
Pubmed

Cdx function is required for maintenance of intestinal identity in the adult.

CDX1 CDX2

1.85e-052150222285812
Pubmed

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.

DYSF MYOF

1.85e-052150218495154
Pubmed

Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.

CDX1 CDX2

1.85e-052150223918153
Pubmed

Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma.

PBRM1 ALDH1A1

1.85e-052150235412614
Pubmed

The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation.

TCF7L2 PPARGC1A

1.85e-052150228795454
Pubmed

Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine.

CDX1 CDX2

1.85e-052150223382958
Pubmed

Cdx binding determines the timing of enhancer activation in postnatal duodenum.

CDX1 CDX2

1.85e-052150215677472
Pubmed

Follow-Up Study on CDX1 and CDX2 mRNA Expression in Noncancerous Gastric Mucosae After Helicobacter pylori Eradication.

CDX1 CDX2

1.85e-052150226841784
Pubmed

[Identity and intestinal pathologies: the Cdx2 homeotic gene].

CDX1 CDX2

1.85e-052150223127929
Pubmed

The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation.

CDX1 CDX2

1.85e-052150217463179
Pubmed

Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.

DYSF MYOF

1.85e-052150211959863
Pubmed

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.

UBE2D2 UBE2D4

1.85e-052150226912277
Pubmed

Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle.

DYSF MYOF

1.85e-052150234354129
Pubmed

Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development.

ALDH1A1 ALDH1A3

1.85e-052150211013254
Pubmed

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.

CDX2 TCF7L2

1.85e-052150220696899
Pubmed

The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells.

CDX2 CDX4

1.85e-05215028910549
Pubmed

Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.

CDX1 CDX4

1.85e-052150221466798
Pubmed

Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment.

CDX2 CDX4

1.85e-052150220816799
Pubmed

Cdx1 and cdx2 expression during intestinal development.

CDX1 CDX2

1.85e-052150211040183
Pubmed

Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans.

KRT72 KRT71

1.85e-052150211703281
Pubmed

The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing.

SVIL PLK1

1.85e-052150223750008
Pubmed

Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.

ALDH1A1 ALDH1A3

1.85e-052150222131125
Pubmed

Regulation of axial elongation by Cdx.

CDX1 CDX2

1.85e-052150234958748
Pubmed

The Cdx-1 and Cdx-2 homeobox genes in the intestine.

CDX1 CDX2

1.85e-052150210392709
Pubmed

Expression of DLG1 and DLG5 in the Intestinal Epithelium of Patients with CD.

DLG5 DLG1

1.85e-052150227760079
Pubmed

Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.

KRAS PLK1

1.85e-052150223566315
Pubmed

Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation.

CFTR EIF3A

1.85e-052150230006345
Pubmed

Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina.

ALDH1A1 ALDH1A3

1.85e-052150211044606
Pubmed

Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.

DYSF MYOF

1.85e-052150231004665
Pubmed

Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.

CDX1 CDX2

1.85e-05215029036867
Pubmed

Cdx regulates gene expression through PRC2-mediated epigenetic mechanisms.

CDX1 CDX2

1.85e-052150234973175
Pubmed

While dysferlin and myoferlin are coexpressed in the human placenta, only dysferlin expression is responsive to trophoblast fusion in model systems.

DYSF MYOF

1.85e-052150219228595
Pubmed

CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer.

CDX1 CDX2

1.85e-052150221532856
Pubmed

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.

KRAS CEMIP

1.85e-052150227922049
Pubmed

[Impact of Cystic Fibrosis Transmembrane Conductance Regulator on Malignant
 Properties of KRAS Mutant Lung Adenocarcinoma A549 Cells].

KRAS CFTR

1.85e-052150229526175
Pubmed

ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.

ALDH1A1 ALDH1A3

1.85e-052150237904003
Pubmed

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.

CDX1 CDX2

1.85e-052150217595234
Pubmed

Essential and redundant functions of caudal family proteins in activating adult intestinal genes.

CDX1 CDX2

1.85e-052150221402776
Pubmed

Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach.

CDX1 CDX2

1.85e-052150219725873
Pubmed

Ubiquitination of STING at lysine 224 controls IRF3 activation.

UBE2D2 UBE2D3 UBE2D4

2.18e-0513150328763789
Pubmed

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

NIBAN2 BRCA2 CHD6

2.18e-0513150328416489
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

DHX16 ZNFX1 CEMIP ASAP2 ALMS1 CNTNAP4

2.24e-05130150612421765
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TM9SF3 ZNFX1 ZDBF2 CASZ1 ANKRD36B CYB5B NCOR2 PBRM1 TXNDC5 UNC5C HFM1 CHD6

2.27e-056381501231182584
Pubmed

Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.

CDX1 CDX2 CDX4

2.76e-0514150319539783
Pubmed

Essential roles for Cdx in murine primitive hematopoiesis.

CDX1 CDX2 CDX4

2.76e-0514150328065741
Pubmed

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

UBE2D2 UBE2D3 UBE2D4

2.76e-0514150336481767
Pubmed

Cdx2 is essential for axial elongation in mouse development.

CDX1 CDX2 CDX4

3.44e-0515150315136723
Pubmed

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex.

GDF5 TCF7L2 GDAP1 RECQL4 DLG1 PLK1

3.98e-05144150630585266
Pubmed

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.

CDX1 CDX2 TCF7L2

4.23e-0516150315057272
Pubmed

Cdx2 regulation of posterior development through non-Hox targets.

CDX1 CDX2 CDX4

4.23e-0516150319906845
Pubmed

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.

CDX2 CDX4 ALDH1A3

4.23e-0516150321752936
Pubmed

Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.

UBE2D2 UBE2D3 UBE2D4

5.12e-0517150333650289
InteractionUVSSA interactions

UBE2D2 UBE2D3 UBE2D4 RECQL4 EMD

7.69e-06371505int:UVSSA
InteractionTRIM35 interactions

TIGAR TCF7L2 OTUD5 NAB2 UBE2D2 UBE2D3 UBE2D4

1.20e-051031507int:TRIM35
InteractionMIB1 interactions

ARHGAP24 TTLL5 CEMIP CRNKL1 UBE2D2 UBE2D3 UBE2D4 EIF3A EMD PIBF1 PLK1

1.35e-0529515011int:MIB1
InteractionCSNK2B interactions

KRAS TCF7L2 MLX UTP14A CHD8 PAF1 SMC5 SHANK3 ATAD2B PIP4K2A RECQL4 TENM1 TNFAIP1 EMD PLK1 RPL5

1.77e-0562515016int:CSNK2B
InteractionTRIM37 interactions

DLG5 MYO1E KRT74 TTLL5 UTP14A TBC1D2B CYB5B NCOR2 MYOF UBE2D2 UBE2D3 ALMS1 SVIL EMD PIBF1 RPL5

1.95e-0563015016int:TRIM37
InteractionDKK3 interactions

ATP5PB IFFO1 SULF2 ALMS1 RECQL4 ASPM

2.03e-05751506int:DKK3
InteractionLZTS2 interactions

DHX16 KRAS DLG5 NEBL TBC1D2B SHANK3 CRNKL1 ALMS1 BRCA2 PIP4K2A RECQL4 ASPM GCC1 EMD

2.98e-0551215014int:LZTS2
InteractionUTP14C interactions

NAB2 UTP14A BRCA2 GCC1 PIBF1

3.46e-05501505int:UTP14C
InteractionPOLM interactions

KRAS UBE2D2 UBE2D3 MTUS1

3.88e-05261504int:POLM
InteractionHSPB8 interactions

MYH3 TCF7L2 NAB2 TBC1D2B ALMS1 BRCA2 ZER1 EMD

4.50e-051721508int:HSPB8
InteractionKRT38 interactions

KRT72 KRT74 TXNDC5 ALMS1 KRT71 BRCA2 ASPM PIBF1

4.50e-051721508int:KRT38
InteractionMYLIP interactions

KRAS PAF1 UBE2D2 UBE2D3 UBE2D4

6.01e-05561505int:MYLIP
InteractionANAPC2 interactions

KRAS DLG5 DNAJC7 UBE2D2 ALMS1 BRCA2 RECQL4 PIBF1 PLK1

6.61e-052341509int:ANAPC2
InteractionCOIL interactions

DHX16 PPIL4 CHD8 PAF1 SMC5 CASZ1 HOXA5 CYB5B CRNKL1 PBRM1 GCC1 CHD6 PLK1 RPL5

6.71e-0555215014int:COIL
GeneFamilyUbiquitin conjugating enzymes E2

UBE2D2 UBE2D3 UBE2D4 UBE2Q2

8.88e-05411044102
GeneFamilyHOXL subclass homeoboxes

CDX1 CDX2 CDX4 HOXA5

2.26e-04521044518
GeneFamilyFerlin family

DYSF MYOF

4.84e-0461042828
GeneFamilyKeratins, type II

KRT72 KRT74 KRT71

4.89e-04271043609
GeneFamilyAdenylate kinases

AK6 AK5

1.15e-0391042356
GeneFamilyPDZ domain containing

DLG5 SHANK3 PREX2 DLG1 RIMS1

1.85e-0315210451220
GeneFamilyAnkyrin repeat domain containing

SHANK3 ANKRD36B ASAP2 ANKRD36 ACAP2 SOWAHB

2.75e-032421046403
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP2 ACAP2

4.21e-031710421291
GeneFamilyAldehyde dehydrogenases

ALDH1A1 ALDH1A3

5.26e-03191042398
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

NOL4 ARHGAP24 RAPGEF5 GDAP1 TBC1D2B CHRM5 SHANK3 CASZ1 ZNF248 CEMIP ANKRD36B PPARGC1A LINGO1 MTUS1 RALGPS1 RASGEF1B TENM1 CNTNAP4 NCOA7 ANKRD36 RIMS1 SSH2 UNC79 UBE2Q2

1.91e-08110615024M39071
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

DLG5 TCF7L2 GDAP1 TBC1D2B PPIL4 CRPPA SMC5 ITPR1 NCOR2 SULF2 BRCA2 ZDHHC6 ATAD2B SVIL ZNF483 CHD6 EIF3A SSH2 ALDH1A3

5.31e-06100915019M157
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

RAPGEF5 SHANK3 ASAP2 SULF2 LINGO1 AK5 RASGEF1B PCDH15 TNFAIP1

2.10e-081941509b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-0820015094dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

MYO1E RAPGEF5 TM9SF3 ZNFX1 ASAP2 UBE2D3 SVIL EIF3A ALDH1A3

2.73e-082001509a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-08200150926b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-0820015091314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-0820015098b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-082001509272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

MYO1E RAPGEF5 DYSF AK5 PIP4K2A UNC5C CNTNAP4 NCOA7 DLG1

2.73e-0820015095f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 CASZ1 ITPR1 PPARGC1A ASAP2 UNC5C HRH2 MAP3K15

1.74e-071791508666072c0e8448dbaec1683d18368ec2502453f90
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

DLG5 DPY19L2 NEBL CFTR PPARGC1A ASAP2 ADAMTS18 NCOA7

1.98e-071821508ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP24 DPY19L2 CASZ1 ITPR1 PPARGC1A ASAP2 UNC5C MAP3K15

1.98e-0718215085f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RGS22 CFTR PPARGC1A PCDH15 TENM1 CNTNAP4 UNC79

2.15e-0718415082cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RGS22 CFTR PPARGC1A PCDH15 TENM1 CNTNAP4 UNC79

2.15e-071841508ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4 RGS22 CFTR PPARGC1A PCDH15 TENM1 CNTNAP4 UNC79

2.15e-0718415082b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

SHANK3 ASAP2 SULF2 LINGO1 AK5 RASGEF1B PCDH15 TNFAIP1

2.44e-0718715087876dcb4800c2e54874df3d933efb79307a64a97
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

DLG5 DPY19L2 NEBL CFTR PPARGC1A ASAP2 ADAMTS18 NCOA7

2.44e-071871508ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SMC5 GGH ALMS1 BRCA2 RECQL4 ASPM HYLS1 ANKRD36

3.22e-071941508dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellfrontal_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIGAR HTR1F DYSF CASZ1 SULF2 TENM1 ADAMTS18

8.59e-071521507f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DLG5 CASZ1 ANKRD36B GRHL1 DLG1 RIMS1 ALDH1A3

2.56e-0617915076e965e424eebef50f0202cff75f458be395cfca1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 NEBL CFTR PPARGC1A ASAP2 ADAMTS18 NCOA7

2.65e-061801507cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAB2 ITPR1 SULF2 LINGO1 UNC5C PCDH15 ALDH1A3

3.79e-061901507e792e42fc49472eaf974eb0905819eb51a1da8e5
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GGH ASAP2 LINGO1 ALMS1 BRCA2 RECQL4 HYLS1

3.79e-061901507250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAB2 ITPR1 SULF2 LINGO1 UNC5C PCDH15 ALDH1A3

4.06e-061921507550a6574a93acadb43c449094565c73ca51a0c5c
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1E RAPGEF5 DYSF SHANK3 PREX2 ASAP2 TNFAIP1

4.35e-06194150758f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1E RAPGEF5 DYSF SHANK3 PREX2 ASAP2 TNFAIP1

4.35e-061941507bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 DYSF SHANK3 PREX2 SULF2 PIP4K2A RASSF3

4.35e-061941507e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCellmild_COVID-19-Classical_Monocyte|World / disease group, cell group and cell class (v2)

OGFRL1 LILRB2 NAB2 NIBAN2 SULF2 RASGEF1B ALDH1A1

4.81e-0619715075d826f4d7b7a46847c67e6bef38eb860bc808a6c
ToppCell(5)_Fibroblasts-(5)_Fibroblast-G|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

GDF5 NEBL RAPGEF5 ITPR1 RASGEF1B PCDH15 ALDH1A1

4.81e-061971507a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

KIAA0930 GGH BRCA2 RECQL4 ASPM HRH2 PLK1

4.97e-0619815075c92687b853ebb00960adbef6552f9d460bc6886
ToppCell(11)_FOXN4+|World / shred by cell type by condition

GGH ALMS1 BRCA2 RECQL4 ASPM HYLS1 OSCP1

4.97e-061981507516b1acdf997dd8debc3dca066519366e507b414
ToppCellsevere-Myeloid-CD14_Monocytes_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CAPN2 NIBAN2 NCOR2 SULF2 RASGEF1B ALDH1A1 RPL5

5.14e-061991507ce07b7c1edfc6e2136dafcf041361b66a52271d3
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

KIAA0930 HTR1F RAPGEF5 ITPR1 LINGO1 HRH2 DLG1

5.31e-0620015074409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DLG5 NEBL NIBAN2 CASZ1 MYOF MTUS1 ALDH1A1

5.31e-062001507ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAPGEF5 DYSF MTUS1 AK5 PIP4K2A UNC5C CNTNAP4

5.31e-062001507829978708463a7459fe1041bd90196775bc4b531
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

HTR1F PCDH20 HOXA5 SVIL UNC5C HFM1

1.44e-05155150683430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

CHD8 CREBL2 CYB5B HRH2 RASSF3 MAP3K15

1.67e-051591506f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

CHD8 CREBL2 CYB5B HRH2 RASSF3 MAP3K15

1.67e-051591506929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellControl-Epithelial_alveolar-Mes-like|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UTP14A SNUPN RCC1L ALKBH8 ALDH1A1 PLK1

2.27e-0516815063c2ce9cfaca8ceab9b29f918ab46afc69eba3330
ToppCellControl-Epithelial_alveolar-Mes-like-AT1_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UTP14A SNUPN RCC1L ALKBH8 ALDH1A1 PLK1

2.27e-05168150649180994311b3f4f9ec338b1d35d8edd7422e3c9
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NOL4 GDAP1 ZDBF2 KCNH2 ZNF483 UNC79

2.43e-051701506941d637cf76918ee4b0a1833abd1a42593cb8b1a
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

KIAA0930 NIBAN2 GGH ASPM HRH2 PLK1

2.68e-051731506783b8fa08b9d8f597f251793eae164151662f1f9
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GDF5 FASTKD1 MPZL1 CEMIP LINGO1 MAP3K15

2.86e-051751506aa168aeb9ad71aa6c0c28a0657c9eb92a0b28183
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|356C / Donor, Lineage, Cell class and subclass (all cells)

OGFRL1 DPY19L2 BRCA2 RECQL4 ASPM PLK1

2.95e-0517615064bba41ebf9dd187c8705a6997ed039878de62b4e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DLG5 NEBL CFTR ASAP2 ADAMTS18 NCOA7

3.15e-05178150651d2188406f04329311b2efd1108fc36617a860e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PPARGC1A TXNDC5 BRCA2 RECQL4 ASPM PLK1

3.25e-051791506021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CFTR NIBAN2 GRHL1 MTUS1 SVIL NCOA7

3.45e-051811506c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 ITPR1 PPARGC1A ASAP2 UNC5C MAP3K15

3.67e-0518315062e831a4d99c6f983793df71c0994124c943c6da9
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CRPPA MTUS1 KCNH2 UNC5C HFM1 RIMS1

3.90e-0518515066712512100ccef456d2e2bd201d0987986c92ac9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 CFTR CASZ1 PPARGC1A MTUS1 ADAMTS18

4.02e-051861506a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellSubstantia_nigra-Neuronal-Inhibitory|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ZDBF2 OGDH KCNH2 CNTNAP4 RIMS1 UNC79

4.02e-0518615069d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

KIAA0930 NIBAN2 DYSF GGH ASPM PLK1

4.02e-051861506e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCelldroplet-Marrow-BM-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0930 CAPN2 NIBAN2 GGH SULF2 TXNDC5

4.02e-051861506bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCellCOVID_non-vent-Myeloid-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

OGFRL1 KIAA0930 MYO1E MYOF ASAP2 SULF2

4.14e-051871506936aaca144b79a809617cbe3058bf434a4b3d46a
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

NEBL MYO1E RAPGEF5 SHANK3 PREX2 SULF2

4.14e-05187150640ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellCOVID_non-vent-Myeloid-Dendritic-cDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

OGFRL1 KIAA0930 MYO1E MYOF ASAP2 SULF2

4.14e-05187150655fe4e8b4f301876716c1af15c34d42164f2358e
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

DPY19L2 NEBL DYSF CASZ1 PPARGC1A SVIL

4.27e-0518815066d249fe92d51a19da19ec14bb2262d394255d577
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL5 CAPN2 CRPPA ZDBF2 MTUS1 ATAD2B

4.27e-0518815066468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL5 CAPN2 CRPPA ZDBF2 MTUS1 ATAD2B

4.27e-0518815067a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

MYO1E RAPGEF5 ITPR1 MYOF SVIL RIMS1

4.27e-05188150634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL5 CAPN2 CRPPA ZDBF2 MTUS1 ATAD2B

4.27e-0518815069cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK11 PPARGC1A MTUS1 ASPM PCDH15 TENM1

4.27e-0518815068de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MYO1E CASZ1 ITPR1 MYOF ADAMTS18 UNC79

4.27e-051881506b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellcontrol-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OGFRL1 KIAA0930 IFFO1 ZNF248 UBE2D4 GCC1

4.40e-051891506bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAPGEF5 SHANK3 SULF2 MTUS1 AK5 PCDH15

4.40e-0518915067346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

RAPGEF5 SHANK3 ITPR1 SULF2 AK5 PCDH15

4.40e-051891506c81787a8c662db5d7814c583dd64562857629e81
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP24 MYO1E PPARGC1A SULF2 UBE2D2 SVIL

4.40e-0518915068c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP24 MYO1E PPARGC1A SULF2 UBE2D2 SVIL

4.40e-0518915065d902a4660a27548764bf04c6de152b565da835c
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GGH ASAP2 LINGO1 BRCA2 RECQL4 HYLS1

4.53e-0519015067be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR1F RAPGEF5 ITPR1 LINGO1 HRH2 DLG1

4.53e-051901506d594da827e3c16644952b9589cc12b947ce36279
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN2 TM9SF3 MYOF KARS1 SULF2 UBE2D2

4.53e-051901506888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN2 TM9SF3 MYOF KARS1 SULF2 UBE2D2

4.53e-0519015063466cebab16964e94da130d0673fa32e7d90b5ed
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK11 CEMIP PPARGC1A MTUS1 ASPM TENM1

4.53e-051901506e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

DPY19L2 NEBL DYSF CASZ1 PPARGC1A SVIL

4.66e-0519115065d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAPGEF5 DYSF SHANK3 PREX2 SULF2 NCOA7

4.66e-0519115062f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP24 NEBL MYO1E GDAP1 MYOF SVIL

4.66e-0519115069032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP24 NEBL MYO1E GDAP1 MYOF SVIL

4.66e-0519115065717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOF UNC5C PCDH15 HRH2 ALDH1A1 ALDH1A3

4.80e-051921506f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAPGEF5 PCDH20 TXNDC5 MTUS1 PIP4K2A CNTNAP4

4.94e-051931506947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

RAPGEF5 SHANK3 ASAP2 SULF2 AK5 PCDH15

4.94e-0519315062531266bc57339d4e2b22a88817008e32b8c1598
ToppCellPSB-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GGH ASAP2 BRCA2 RECQL4 ASPM HYLS1

4.94e-051931506b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAPGEF5 MTUS1 AK5 PIP4K2A CNTNAP4 DLG1

5.08e-051941506cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac|Lung / Manually curated celltypes from each tissue

GGH BRCA2 RECQL4 ASPM PLK1 PIWIL3

5.08e-051941506a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TCF7L2 LILRB2 SULF2 HRH2 RASSF3 SSH2

5.08e-051941506e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

GGH ASAP2 ALMS1 BRCA2 HYLS1 ANKRD36

5.08e-0519415065dffa578149104dda33774361e9e77b227b5f1ce
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TCF7L2 LILRB2 SULF2 HRH2 RASSF3 SSH2

5.08e-0519415060bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 DYSF SHANK3 PREX2 ADAMTS18 RASSF3

5.08e-051941506fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCellbackground-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

RAPGEF5 SHANK3 PREX2 PIP4K2A RASGEF1B NCOA7

5.23e-051951506c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_1|343B / Donor, Lineage, Cell class and subclass (all cells)

OGFRL1 GGH BRCA2 RECQL4 ASPM PLK1

5.23e-05195150647a01b8a92eebeb34ac7f70bf1ab4613a326e24f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 DYSF SHANK3 PREX2 SULF2 RASSF3

5.38e-051961506023312af38f816a44b407e0daa32590d953caf99
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAPGEF5 CHRM5 AK5 PIP4K2A UNC5C CNTNAP4

5.53e-051971506032ccc91e604113da9bc34a6f9ddb1d45dea1892
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAPGEF5 MTUS1 AK5 PIP4K2A UNC5C CNTNAP4

5.53e-05197150682b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGFRL1 TCF7L2 NIBAN2 SULF2 ALDH1A3 SOWAHB

5.53e-051971506ed3a37f532741764060d297a560eeeeec279d9c4
ToppCellCOVID-19_Severe-Non-classical_Monocyte|World / disease group, cell group and cell class

TCF7L2 NEBL LILRB2 MYOF SVIL RASGEF1B

5.53e-05197150660fee75b12451206bb2c07b61651a73c59ec6ade
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RAPGEF5 DYSF SHANK3 PREX2 SULF2 RASSF3

5.53e-051971506412cb5f37df57121ddd1492021445479c7cbccbf
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRB2 SULF2 RASGEF1B HRH2 RIMS1 ALDH1A1

5.69e-051981506a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell(3)_DC_Monocyte_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

OGFRL1 GGH BRCA2 RECQL4 ASPM PLK1

5.69e-051981506e2b89f6d7c0007ccab62495cd543fe0e5513a9a4
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAPGEF5 DYSF SHANK3 PREX2 LINGO1 RASGEF1B

5.69e-05198150645419f2804b4be79bae6632e71c54e1af482d115
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

MYO1E PREX2 MYOF SVIL ADAMTS18 NCOA7

5.69e-051981506b8bd1ba268480f54451648e01631b615a3401144
ToppCellMonocytes|World / Immune cells in Kidney/Urine in Lupus Nephritis

OGFRL1 KIAA0930 TCF7L2 LILRB2 ADORA3 MYOF

5.69e-0519815068beccf03c9ec9cd02a96107a9d7ca9a6764c6a61
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SMC5 GGH ASAP2 BRCA2 HYLS1 ANKRD36

5.69e-0519815066b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A

TCF7L2 FASTKD1 CHD8 ZNF248 HOXA5 ALMS1 ASPM PLK1 ACAP2

3.30e-0618115091791_DN
DrugAlexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; HL60; HT_HG-U133A

NEBL LILRB2 TTLL5 MPZL1 ADORA3 MYOF MTUS1 PIP4K2A TNFAIP1

6.31e-0619615092576_DN
DrugNefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; PC3; HT_HG-U133A

ARHGAP24 IFFO1 TTLL5 CFTR NAB2 UTP14A AK5 RALGPS1 ZER1

6.84e-0619815093730_DN
Diseaseurate measurement

NOL4 TCF7L2 NEBL RAPGEF5 SNX17 AK6 DYSF KCNK9 CEMIP CYB5B ASAP2 AK5 NCOA7 HFM1 UBE2Q2

4.67e-0589514815EFO_0004531
DiseaseVertigo

TIGAR CAPN2 ARMC9 CHRM5 SVIL RIMS1

7.47e-051391486HP_0002321
Diseasediastolic blood pressure, systolic blood pressure

TIGAR ARMC9 KCNK9 CASZ1 CEMIP CYB5B PPARGC1A ALMS1 SVIL PIP4K2A CHD6 PIBF1

1.50e-0467014812EFO_0006335, EFO_0006336
DiseaseJoubert syndrome 1

ARMC9 HYLS1 PIBF1

1.54e-04211483C4551568
DiseaseCiliopathies

CFTR CCDC39 NPHP3 PCDH15 HYLS1

2.38e-041101485C4277690
DiseaseWoolly hair, congenital

KRT74 KRT71

2.47e-0451482C0345427
DiseaseKlatskin's tumor (is_implicated_in)

KRAS PREX2

2.47e-0451482DOID:4927 (is_implicated_in)
Diseaseretinal vasculature measurement

DHX16 TCF7L2 TTLL5 NIBAN2 DYSF COG8 ITPR1 MYOF LINGO1 RASGEF1B

2.95e-0451714810EFO_0010554
DiseasePolydactyly

GDF5 LMBR1 NPHP3 ALMS1 HYLS1

3.17e-041171485C0152427
Diseaseelectrocardiography

ARHGAP24 ZNFX1 ARMC9 CASZ1 CEMIP PPARGC1A KCNH2 SVIL ADAMTS18 NCOA7

3.59e-0453014810EFO_0004327
DiseaseHypotrichosis

KRT74 KRT71

3.70e-0461482C0020678
DiseasePituitary Gland Adenoma

NEBL PCDH15

3.70e-0461482EFO_1000478
DiseaseFamilial aplasia of the vermis

ARMC9 HYLS1 PIBF1

4.55e-04301483C0431399
Diseasecreatinine measurement

TCF7L2 SNX17 ARMC9 SNUPN CASZ1 BRWD3 CEMIP PPARGC1A UBE2D3 ALMS1 SVIL NCOA7 DLG1 UBE2Q2

5.03e-0499514814EFO_0004518
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD8 CHD6

5.16e-0471482DOID:0050834 (implicated_via_orthology)
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

DYSF MYOF

5.16e-0471482DOID:11724 (implicated_via_orthology)
DiseaseWooly hair

KRT74 KRT71

5.16e-0471482C0343073
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

TCF7L2 CYB5B SULF2 AK5 RALGPS1 DLG1 SSH2 UNC79

5.23e-043641488EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseSchizophrenia

TCF7L2 HTR1F MPZL1 CHRM5 SHANK3 PPARGC1A PBRM1 TXNDC5 KCNH2 PIP4K2A UNC5C DLG1 ALDH1A1

5.27e-0488314813C0036341
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

KRAS TCF7L2 TTLL5 DYSF RASGEF1B

5.32e-041311485C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

KRAS TCF7L2 TTLL5 DYSF RASGEF1B

5.32e-041311485C4552091
DiseaseJuvenile arthritis

KRAS TCF7L2 TTLL5 DYSF RASGEF1B

5.32e-041311485C3495559
DiseaseJuvenile psoriatic arthritis

KRAS TCF7L2 TTLL5 DYSF RASGEF1B

5.32e-041311485C3714758
DiseaseSquamous cell carcinoma of lung

KRAS MAP3K15 PLK1

5.51e-04321483C0149782
DiseaseJuvenile-Onset Still Disease

KRAS TCF7L2 TTLL5 DYSF RASGEF1B

6.10e-041351485C0087031
DiseaseMalignant neoplasm of urinary bladder

KRAS GGH BRCA2 RALGPS1 CHD6

7.42e-041411485C0005684
Diseaseobesity (implicated_via_orthology)

TCF7L2 CAPN2 ITPR1 PPARGC1A ALMS1 ALDH1A1

7.79e-042151486DOID:9970 (implicated_via_orthology)
Diseaseage at menarche

NOL4 TCF7L2 KCNK9 PCDH20 CYB5B SULF2 LINGO1 ALMS1 ZNF483 UNC79

8.64e-0459414810EFO_0004703
DiseasePancreatic carcinoma, familial

KRAS BRCA2

8.79e-0491482C2931038
DiseaseAutosomal Recessive Polycystic Kidney Disease

CFTR NPHP3

8.79e-0491482C0085548
Diseaseresponse to anticonvulsant

TDRD15 NEBL PREX2 SOWAHB

8.98e-04851484GO_0036277
Diseaseautism spectrum disorder (implicated_via_orthology)

CHD8 SHANK3 CNTNAP4 CHD6 RIMS1

1.04e-031521485DOID:0060041 (implicated_via_orthology)
DiseaseNeoplasm of uncertain or unknown behavior of breast

KRAS PBRM1 BRCA2

1.15e-03411483C0496956
DiseaseBreast adenocarcinoma

KRAS PBRM1 BRCA2

1.15e-03411483C0858252
DiseaseCarcinoma, Transitional Cell

GGH HRH2 CHD6

1.15e-03411483C0007138
Diseasealbuminuria

TCF7L2 RAPGEF5 SNX17 AK5

1.31e-03941484EFO_0004285
DiseaseMacrocephaly

CHD8 BRWD3

1.33e-03111482C0221355
Diseasewaist circumference

TCF7L2 NEBL CFTR CAPN2 GDAP1 CYB5B RASGEF1B PIBF1

1.50e-034291488EFO_0004342
Diseaseeye disease

TCF7L2 RASGEF1B TMCO1

1.50e-03451483EFO_0003966
Diseasedistal myopathy (implicated_via_orthology)

MYH3 DYSF

1.60e-03121482DOID:11720 (implicated_via_orthology)
Diseaseresponse to hydrochlorothiazide, fasting blood glucose measurement

KRAS ARMC9 PCDH15

1.60e-03461483EFO_0004465, EFO_0005202
Diseaseovary epithelial cancer (is_marker_for)

ASPM PLK1

1.88e-03131482DOID:2152 (is_marker_for)
DiseaseBenign tumor of pancreas

KRAS BRCA2

1.88e-03131482C0347284
DiseaseIntellectual Disability

SNX3 CHD8 ARMC9 SHANK3 BRWD3 KARS1 ALKBH8 TMCO1

1.94e-034471488C3714756
Diseasesitting height ratio

TCF7L2 CRPPA ATAD2B

2.16e-03511483EFO_0007118
Diseasebalding measurement

DLG5 TCF7L2 KRT74 RGS22 CRPPA CASZ1 ITPR1 NCOR2 SULF2 KRT71 ADAMTS18

2.23e-0379214811EFO_0007825
Diseasepancreatic cancer (is_implicated_in)

KRAS TCF7L2 CFTR BRCA2

2.48e-031121484DOID:1793 (is_implicated_in)
DiseaseN-acetylmethionine measurement

ITPR1 ALMS1

2.51e-03151482EFO_0021427
DiseaseHuntington's disease (biomarker_via_orthology)

ITPR1 PPARGC1A

2.86e-03161482DOID:12858 (biomarker_via_orthology)
Diseasedysmenorrheic pain measurement

KRAS GDAP1

2.86e-03161482EFO_0007889
Diseasecleft lip

LILRB2 CCDC168 KCNK9 NCOR2 SVIL PIP4K2A

3.18e-032841486EFO_0003959
Diseaseuridine diphosphate galactose measurement, uridine diphosphate glucose measurement

SVIL ADAMTS18

3.23e-03171482EFO_0010543, EFO_0010544
Diseasemicroglial activation measurement

ARHGAP24 ARMC9 PCDH20

3.27e-03591483EFO_0010940
Diseaseneuroimaging measurement, brain volume measurement

GDF5 TCF7L2 CYB5B PPARGC1A PBRM1 NCOA7

3.29e-032861486EFO_0004346, EFO_0006930
Diseasebody fat percentage

TCF7L2 CYB5B SULF2 AK5 RALGPS1 DLG1 SSH2 UNC79

3.32e-034881488EFO_0007800
DiseaseMeckel syndrome type 1

NPHP3 HYLS1

3.63e-03181482C3714506
DiseasePancreatic carcinoma

KRAS BRCA2

4.04e-03191482C0235974
Diseasediet measurement, HOMA-B

CREBL2 CYB5B

4.04e-03191482EFO_0004469, EFO_0008111
Diseaseemphysema pattern measurement

SVIL SOWAHB

4.04e-03191482EFO_0005850
Diseaseattention deficit hyperactivity disorder, schizophrenia

TCF7L2 NAB2 UBE2D3

4.12e-03641483EFO_0003888, MONDO_0005090
DiseaseDisorder of eye

KCNV2 NPHP3 ALMS1 PCDH15 RIMS1

4.40e-032121485C0015397
Diseaseheart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer

TCF7L2 GRHL1

4.47e-03201482EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Diseasecalcium measurement

KRAS TBC1D2B CRPPA CHD8 ITPR1 GGH GRHL1 ASAP2 HFM1

4.54e-036281489EFO_0004838
Diseasesocial deprivation, COVID-19

ARHGAP24 PCDH20

4.93e-03211482EFO_0009696, MONDO_0100096
DiseaseBREAST CANCER

KRAS BRCA2

4.93e-03211482114480

Protein segments in the cluster

PeptideGeneStartEntry
TRTKDKYRVVYTDHQ

CDX1

151

P47902
VKTRTKDKYRVVYTD

CDX2

181

Q99626
KDKYRVVYTDHQRLE

CDX2

186

Q99626
RTKEKYRVVYTDHQR

CDX4

171

O14627
AVKVYRLITRNSYER

CHD8

1251

Q9HCK8
KLTRYRSEKVTISYA

AMMECR1L

271

Q6DCA0
TELKLTRKAAYVRYF

CFTR

291

P13569
RVRRIHVKRYSTYDD

TNFAIP1

291

Q13829
RYRAITDAVEYARKR

HTR1F

121

P30939
VDRYLRVKLTVRYKR

ADORA3

106

P0DMS8
RYRTTEESKRAYVTL

ALKBH8

86

Q96BT7
SKRARFSKYEEYIRK

CASZ1

231

Q86V15
KRSLYVRALFDYDKT

DLG1

581

Q12959
EKRKSEYKSYRLRAQ

ALMS1

4136

Q8TCU4
VYSEFVRRSVEYAKK

ALDH1A3

326

P47895
AVRIYQQKRLYKRSE

CNTNAP4

1261

Q9C0A0
DRVTVLYRSKAIRYT

COQ6

161

Q9Y2Z9
YVRAVRKSKIYSVNL

BRWD3

956

Q6RI45
YDEFVRRSVERAKKY

ALDH1A1

316

P00352
LLLTYYDANKRDRKE

ANKRD36

51

A6QL64
LTYYDANKRDRKERT

ANKRD36B

41

Q8N2N9
RQEKEAYIRAKYVER

ACAP2

496

Q15057
KYKRRVRDLAREYRA

DHX16

271

O60231
RFDTYRSKKESERLV

CEMIP

206

Q8WUJ3
KKYATYRASAIIIQR

ASPM

2061

Q8IZT6
SRSKVVDRIYSLYKL

ASPM

3391

Q8IZT6
TYRERLYRVYKEVKN

ATP5PB

181

P24539
VLYKRTAEEKIQRYR

ADAMTS18

201

Q8TE60
VDEKYRYKQRQIREL

CCDC39

736

Q9UFE4
RSRKDKTRGYEYVLE

RCC1L

146

Q96I51
FYTLVREIRQYRLKK

KRAS

156

P01116
LKRRYTAYRQKLEEA

RASSF3

216

Q86WH2
EDNYKRTREYIRSLK

RALGPS1

181

Q5JS13
YKRDLYAAESIIKER

CRPPA

266

A4D126
RVLERVLKKYDYDSS

NIBAN2

471

Q96TA1
YQTDLYERERSKKRD

PPIL4

461

Q8WUA2
VLYERLETRGYNEKK

AK6

101

Q9Y3D8
IRIKGKYNISSEDYR

KCNK9

46

Q9NPC2
AYKESYKDRRRRAHT

MLX

121

Q9UH92
RRRAKESKVREYYEK

NCOR2

321

Q9Y618
QLDREEKEKYRYTVR

PCDH20

596

Q8N6Y1
EYFVYTIRDRRERRK

OGFRL1

281

Q5TC84
YEAVKNYTDKRGRRL

PBRM1

666

Q86U86
DKTVYEYLFSQRRKR

GDF5

366

P43026
YNYRVVKEILIRLSK

ITPR1

1181

Q14643
TKTIAKRLEAYYRAS

AK5

511

Q9Y6K8
RLKEFYTREYEKLRD

MTUS1

1006

Q9ULD2
RKYSIIYGRFDSKRR

NAB2

296

Q15742
YFIITRYKRKSDEQE

LMBR1

36

Q8WVP7
IYRHRKDYDKSQLVE

ATAD2B

1431

Q9ULI0
ARKDYITAKYIERRY

ASAP2

521

O43150
ERRSVTYLKRYNKIQ

ARMC9

221

Q7Z3E5
RLVRVARKLDRYSEY

KCNH2

531

Q12809
SIRYEALKKVYDNRV

KIAA0930

206

Q6ICG6
LETYYERVLKRKTFN

GDAP1

276

Q8TB36
KRARTAYTRYQTLEL

HOXA5

196

P20719
LRVFKARIYTNRYET

FBXO39

396

Q8N4B4
TLQEIYRKYRKLIES

FBXO39

416

Q8N4B4
TYYRIFKVARDQAKR

HRH2

201

P25021
ELAAYVRRLERKYSS

COG8

176

Q96MW5
DYDALRKRYSEKVAI

DLG5

316

Q8TDM6
GSLEAQEYRLYREKK

LILRB2

51

Q8N423
RDYSFKRLYRLKVLE

LINGO1

231

Q96FE5
LRARTKIVYSTYSRK

DPY19L2

666

Q6NUT2
ILAVLYRRKNSKRDY

MPZL1

186

O95297
YSERKKTRNLEAYVE

RASGEF1B

246

Q0VAM2
YKEQVRKIGEEARRY

RIMS1

91

Q86UR5
LYNVLAKVKRERDEY

IFFO1

241

Q0D2I5
YAYSVRDSKLRDILK

HFM1

566

A2PYH4
KREEYRREYEKRESE

PPARGC1A

646

Q9UBK2
GKVYYDLTRERKARD

OGDH

906

Q02218
LRKRLNYEDKTRYFV

PCDH15

216

Q96QU1
VYYNELETRVRLSKR

PAF1

321

Q8N7H5
KLEDTVRYEKRYGNR

ARHGAP24

136

Q8N264
RVRVIYKYALDRISK

CRNKL1

431

Q9BZJ0
YQARLKDVVRAYKSL

GCC1

31

Q96CN9
NRGKTDRVARYFEYK

HYLS1

206

Q96M11
DYYKVPRERRSSTAK

GRHL1

66

Q9NZI5
YEKRREFEKLTQVYR

DOCK11

1726

Q5JSL3
LKYRYDTEIDRSRRS

BRCA2

2656

P51587
DLRRSDYAKVAKIFY

GGH

101

Q92820
RQRKEERRITYYREK

EIF3A

796

Q14152
AVKVYRLITRNSYER

CHD6

901

Q8TD26
SARECRARKKLRYQY

CREBL2

36

O60519
RARKKLRYQYLEELV

CREBL2

41

O60519
YYRLEEVAKRNSLKE

CYB5B

26

O43169
AKSIAKFLRNVRYRY

FASTKD1

231

Q53R41
VKLDDTYIKAYLRRA

DNAJC7

321

Q99615
RRLYEKKIFEYETQR

EMD

31

P50402
TRREKAEYVTEITRY

CCDC168

4101

Q8NDH2
RDRKKRVYDYESERL

CCDC168

6971

Q8NDH2
KYQKIYREIDVDRSG

CAPN2

606

P17655
DDKRRYDSIKRYLCT

PIWIL3

586

Q7Z3Z3
LRVEKYLRRRKYSLF

DYSF

581

O75923
TLVSVYCTRKKYRER

MEP1B

671

Q16820
VYRKYDLKGSTVARE

PIP4K2A

206

P48426
KSSRDYRRAAKYDVI

KRBA2

151

Q6ZNG9
YVTEDFTTYINRKRK

OTUD5

261

Q96G74
VYYKETLLNDIRKAR

MAP3K15

241

Q6ZN16
VKYDSRLRERKYGVV

TIGAR

81

Q9NQ88
VYRTDKYKRLKAEVE

TMCO1

81

Q9UM00
ARYKAERRRQLAEKY

SVIL

106

O95425
KDKETRYRQRYLDLI

KARS1

221

Q15046
RYSKDRRFYRAVITE

TDRD15

541

B5MCY1
LKEIRRTELKRYYSI

NCOA7

76

Q8NI08
YERLRKEYEIFRVSK

NPHP3

91

Q7Z494
ITYRDRNQRKAKSIY

RGS22

891

Q8NE09
EETRALYREYRTLKR

RECQL4

36

O94761
SKLKAYEYTTIRRER

KCNV2

501

Q8TDN2
EYHYKSKVRVLRIDA

SOCS4

421

Q8WXH5
KSLEASGRIYVYRKD

RAPGEF5

306

Q92565
YQVKFRRRREGKTDY

RPL5

16

P46777
GKTDYYARKRLVIQD

RPL5

26

P46777
RRVLYKYTKQARLSE

TENM1

1966

Q9UKZ4
LRKYERRVKELTYQS

MYH3

1841

P11055
YKSKYSSLEQSERRR

SNUPN

31

O95149
LYSKKALRTVYERLA

OSCP1

71

Q8WVF1
DGTKYVVLKRRYRDL

SOWAHB

66

A6NEL2
YQERARKRIRTYLKS

NOL4

451

O94818
ILYCRIYRETEKRTK

CHRM5

211

P08912
SLRSQEYKIVLRKSY

SNX17

191

Q15036
KRVRSVRYKVIEDYS

ZDHHC6

311

Q9H6R6
IYKTDREKYNRIARE

UBE2D2

126

P62837
RSYNYKKSRKVFRQT

ZFP28

811

Q8NHY6
KELRDIYRSQSYKTG

UBE2Q2

211

Q8WVN8
SRKKYDVRRVYLGEA

ZNF653

51

Q96CK0
DRLSSYYKFKLTREV

ZER1

256

Q7Z7L7
DRAYDYVKERRTVTK

SSH2

416

Q76I76
RYKRRVYAQNLIDDK

SHANK3

91

Q9BYB0
LSREEQAKYYELARK

TCF7L2

391

Q9NQB0
YRYLIESVRQRDSKI

PIBF1

626

Q8WXW3
IYKTDRDKYNRISRE

UBE2D3

126

P61077
DIIRKYISKYSVFLR

ZDBF2

2221

Q9HCK1
VIRDKDYHLRTYKSV

PREX2

496

Q70Z35
RALQSYYEAKARREK

UTP14A

231

Q9BVJ6
KLKESTVRRRYSDFE

SNX3

61

O60493
RRKILSYERQYRTSA

ZNFX1

946

Q9P2E3
RTLRKDYARYSKEEE

TM9SF3

246

Q9HD45
LRVYLRKKSRRYNES

ZNF483

321

Q8TF39
QYKGKRDLESLREYV

TXNDC5

276

Q8NBS9
TYKADREKYNRLARE

UBE2D4

126

Q9Y2X8
YDKYGIRIRVKFRSS

SMC5

966

Q8IY18
RKAYVRIAYLRKTFE

UNC5C

156

O95185
KYLRYFTRTILDARK

TBC1D2B

886

Q9UPU7
KSYLEILAEVRDYKR

SNRNP48

206

Q6IEG0
ILAEVRDYKRRRQSY

SNRNP48

211

Q6IEG0
KYKASYVRSRSIRSV

SULF2

526

Q8IWU5
QGAYTRKILREYKVS

ZNF248

316

Q8NDW4
ERYHLSYKIVRTDSR

TTLL5

61

Q6EMB2
YELTRKDRLYKNIIR

TTLL5

126

Q6EMB2
YRAFTKERDKFYLSR

UNC79

2246

Q9P2D8
TYIDEKRDFRTYRLS

PLK1

551

P53350
LRNVRDVVEDYKKRY

KRT71

206

Q3SY84
YKKRYEVEINRRTAA

KRT72

211

Q14CN4
YKKRYEVEINRRTTA

KRT74

226

Q7RTS7
RERKYDGYARVIQKS

MYO1E

691

Q12965
DLLVVEKYQRRRKYS

MYOF

561

Q9NZM1
EKYQRRRKYSLSAVF

MYOF

566

Q9NZM1
LRAKRTSEIYSQRKY

NEBL

546

O76041