Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion sensor activity	MICU3 MICU1	1.73e-04	7	58	2	GO:0061891
GeneOntologyMolecularFunction	metal ion sensor activity	MICU3 MICU1	2.30e-04	8	58	2	GO:0140784
GeneOntologyMolecularFunction	chromatin binding	BRIP1 L3MBTL2 RBL1 ELK1 SIN3A ACSS2 MBD2 CLOCK MBD3	2.60e-04	739	58	9	GO:0003682
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC26A5 SLC6A5 GRIN1 SLC2A1 SLC6A14	3.35e-04	207	58	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC26A5 SLC6A5 GRIN1 SLC2A1 SLC6A14	3.42e-04	208	58	5	GO:0005342
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	MORC1 TUT4 BRIP1 IGF1R ENPP2 SMCHD1 FNDC3A RSPH6A GRIN1 SPATA2 AP3B1 MBD2 CLOCK	2.56e-05	1194	59	13	GO:0048609
GeneOntologyCellularComponent	uniplex complex	MICU3 MICU1	1.17e-04	6	59	2	GO:1990246
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	EFHC1 DNAH12 AP3B2 UHMK1 RSPH6A AP3B1	2.66e-04	317	59	6	GO:0032838
GeneOntologyCellularComponent	cytoplasmic region	EFHC1 DNAH12 AP3B2 UHMK1 RSPH6A AP3B1	5.23e-04	360	59	6	GO:0099568
GeneOntologyCellularComponent	AP-3 adaptor complex	AP3B2 AP3B1	5.99e-04	13	59	2	GO:0030123
GeneOntologyCellularComponent	presynapse	RPL22 SYNJ1 ICA1 AP3B2 SLC6A5 C1QB ELK1 GRIN1 SLC2A1	7.93e-04	886	59	9	GO:0098793
GeneOntologyCellularComponent	axon	IGF1R SYNJ1 MYO9A AP3B2 UHMK1 ELK1 GRIN1 AP3B1 TENM2	8.25e-04	891	59	9	GO:0030424
GeneOntologyCellularComponent	CHD-type complex	MBD2 MBD3	1.04e-03	17	59	2	GO:0090545
GeneOntologyCellularComponent	NuRD complex	MBD2 MBD3	1.04e-03	17	59	2	GO:0016581
HumanPheno	Status epilepticus	EFHC1 AGO1 SYNJ1 AP3B2 GRIN1 SLC2A1 MICU1	1.68e-05	207	22	7	HP:0002133
Domain	AP3_beta	AP3B2 AP3B1	9.48e-06	2	58	2	IPR026740
Domain	AP3B_C	AP3B2 AP3B1	9.48e-06	2	58	2	IPR029390
Domain	AP3B1_C	AP3B2 AP3B1	9.48e-06	2	58	2	PF14796
Domain	AP3B1_C	AP3B2 AP3B1	9.48e-06	2	58	2	SM01355
Domain	AP_beta	AP3B2 AP3B1	9.42e-05	5	58	2	IPR026739
Domain	MeCpG-bd_2/3_C_dom	MBD2 MBD3	1.97e-04	7	58	2	IPR025884
Domain	E-NPP	ENPP6 ENPP2	1.97e-04	7	58	2	IPR024873
Domain	MBD2/MBD3_p55-bd	MBD2 MBD3	1.97e-04	7	58	2	IPR032343
Domain	MBD_C	MBD2 MBD3	1.97e-04	7	58	2	PF14048
Domain	MBDa	MBD2 MBD3	1.97e-04	7	58	2	PF16564
Domain	-	MBD2 MBD3	2.62e-04	8	58	2	3.30.890.10
Domain	Phosphodiest	ENPP6 ENPP2	4.20e-04	10	58	2	PF01663
Domain	Phosphodiest/P_Trfase	ENPP6 ENPP2	4.20e-04	10	58	2	IPR002591
Domain	Methyl_CpG_DNA-bd	MBD2 MBD3	5.12e-04	11	58	2	IPR001739
Domain	MBD	MBD2 MBD3	5.12e-04	11	58	2	PF01429
Domain	DNA-bd_dom	MBD2 MBD3	5.12e-04	11	58	2	IPR016177
Domain	MBD	MBD2 MBD3	5.12e-04	11	58	2	SM00391
Domain	MBD	MBD2 MBD3	5.12e-04	11	58	2	PS50982
Domain	Clathrin/coatomer_adapt-like_N	AP3B2 AP3B1	9.70e-04	15	58	2	IPR002553
Domain	Adaptin_N	AP3B2 AP3B1	9.70e-04	15	58	2	PF01602
Domain	NA_NEUROTRAN_SYMP_2	SLC6A5 SLC6A14	1.40e-03	18	58	2	PS00754
Domain	SNF	SLC6A5 SLC6A14	1.57e-03	19	58	2	PF00209
Domain	NA_NEUROTRAN_SYMP_1	SLC6A5 SLC6A14	1.57e-03	19	58	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A5 SLC6A14	1.57e-03	19	58	2	PS50267
Domain	Na/ntran_symport	SLC6A5 SLC6A14	1.57e-03	19	58	2	IPR000175
Domain	-	MORC1 SMCHD1	1.74e-03	20	58	2	3.30.565.10
Domain	HATPase_C	MORC1 SMCHD1	1.92e-03	21	58	2	IPR003594
Domain	Alkaline_phosphatase_core	ENPP6 ENPP2	4.16e-03	31	58	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ENPP6 ENPP2	4.16e-03	31	58	2	IPR017849
Domain	-	ENPP6 ENPP2	4.16e-03	31	58	2	3.40.720.10
Domain	C1Q	MMRN1 C1QB	4.43e-03	32	58	2	SM00110
Domain	C1q	MMRN1 C1QB	4.43e-03	32	58	2	PF00386
Domain	EF-hand_8	MICU3 MICU1	4.99e-03	34	58	2	PF13833
Domain	C1q_dom	MMRN1 C1QB	4.99e-03	34	58	2	IPR001073
Domain	C1Q	MMRN1 C1QB	4.99e-03	34	58	2	PS50871
Domain	Myosin_head_motor_dom	MYO9A MYO15A	6.20e-03	38	58	2	IPR001609
Domain	MYOSIN_MOTOR	MYO9A MYO15A	6.20e-03	38	58	2	PS51456
Domain	Myosin_head	MYO9A MYO15A	6.20e-03	38	58	2	PF00063
Domain	MYSc	MYO9A MYO15A	6.20e-03	38	58	2	SM00242
Pubmed	Helios is a key transcriptional regulator of outer hair cell maturation.	RPL22 SLC26A5 MYO15A	1.62e-07	7	59	3	30464345
Pubmed	MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.	SIN3A MBD2 MBD3	7.58e-07	11	59	3	15456747
Pubmed	The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.	SIN3A MBD2 MBD3	1.31e-06	13	59	3	12124384
Pubmed	Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.	SIN3A MBD2 MBD3	2.08e-06	15	59	3	9804427
Pubmed	Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.	SIN3A MBD2 MBD3	2.56e-06	16	59	3	11102443
Pubmed	Loss of mitochondrial Ca2+ uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity.	MICU3 MICU1	2.83e-06	2	59	2	38018177
Pubmed	Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.	ZNF585A ZNF585B	2.83e-06	2	59	2	37668106
Pubmed	NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain.	RPL22 GRIN1	2.83e-06	2	59	2	34630033
Pubmed	Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.	MBD2 MBD3	2.83e-06	2	59	2	24307175
Pubmed	Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3.	MBD2 MBD3	2.83e-06	2	59	2	36037972
Pubmed	Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.	MBD2 MBD3	2.83e-06	2	59	2	11274056
Pubmed	Reduced mRNA expression levels of MBD2 and MBD3 in gastric carcinogenesis.	MBD2 MBD3	2.83e-06	2	59	2	24338710
Pubmed	Structural analyses reveal that MBD3 is a methylated CG binder.	MBD2 MBD3	2.83e-06	2	59	2	30980593
Pubmed	The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A.	SIN3A MBD2	2.83e-06	2	59	2	10950960
Pubmed	MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.	MICU3 MICU1	2.83e-06	2	59	2	29725115
Pubmed	DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells.	MBD2 MBD3	2.83e-06	2	59	2	27849519
Pubmed	Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.	MBD2 MBD3	2.83e-06	2	59	2	23361464
Pubmed	Prestin is expressed on the whole outer hair cell basolateral surface.	SLC26A5 SLC6A5	2.83e-06	2	59	2	16709400
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	SIN3A MBD2 MBD3	3.72e-06	18	59	3	9790534
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	SIN3A MBD2 MBD3	3.72e-06	18	59	3	10444591
Pubmed	Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes.	ELK1 SLC2A1	8.48e-06	3	59	2	21846717
Pubmed	Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.	SYNJ1 PAK5	8.48e-06	3	59	2	22371566
Pubmed	MiR-505 suppressed the growth of hepatocellular carcinoma cells via targeting IGF-1R.	IGF1R SLC2A1	8.48e-06	3	59	2	31160483
Pubmed	Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.	MBD2 MBD3	8.48e-06	3	59	2	14610093
Pubmed	MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.	MBD2 MBD3	8.48e-06	3	59	2	10947852
Pubmed	Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.	ELK1 SIN3A	8.48e-06	3	59	2	11283259
Pubmed	The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.	AP3B2 AP3B1	8.48e-06	3	59	2	10930456
Pubmed	Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios.	MBD2 MBD3	8.48e-06	3	59	2	24849540
Pubmed	Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.	MBD2 MBD3	8.48e-06	3	59	2	19781662
Pubmed	The insulin-like growth factor I receptor regulates glucose transport by astrocytes.	IGF1R SLC2A1	8.48e-06	3	59	2	27462832
Pubmed	Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter.	MICU3 MICU1	8.48e-06	3	59	2	30699349
Pubmed	Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.	IGF1R ELK1	8.48e-06	3	59	2	31366500
Pubmed	Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.	TUT4 AP3B2 MBD2	9.15e-06	24	59	3	26178733
Pubmed	Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission.	MICU3 MICU1	1.69e-05	4	59	2	31862210
Pubmed	MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.	MICU3 MICU1	1.69e-05	4	59	2	23409044
Pubmed	A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.	RPL22 SLC26A5	1.69e-05	4	59	2	34592158
Pubmed	Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse.	IGF1R SLC2A1	1.69e-05	4	59	2	10100151
Pubmed	Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.	AP3B2 AP3B1	1.69e-05	4	59	2	16788073
Pubmed	Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.	SLC26A5 MYO15A	1.69e-05	4	59	2	35100259
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	IGF1R AGO1 RBL1 PAK5 SIN3A PLK4 MBD3 TUBAL3 STK25	2.15e-05	910	59	9	36736316
Pubmed	Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.	AP3B2 AP3B1	2.82e-05	5	59	2	37812725
Pubmed	Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.	SLC26A5 MYO15A	2.82e-05	5	59	2	20505086
Pubmed	Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).	MBD2 MBD3	2.82e-05	5	59	2	23239876
Pubmed	Analysis of expression of membrane-bound tumor markers in ductal carcinoma in situ of the breast: paving the way for molecular imaging.	IGF1R SLC2A1	2.82e-05	5	59	2	23744486
Pubmed	Association analysis between schizophrenia and the AP-3 complex genes.	AP3B2 AP3B1	2.82e-05	5	59	2	19481122
Pubmed	Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA.	MBD2 MBD3	2.82e-05	5	59	2	11371345
Pubmed	Identification and characterization of a family of mammalian methyl-CpG binding proteins.	MBD2 MBD3	2.82e-05	5	59	2	9774669
Pubmed	Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development.	MBD2 MBD3	2.82e-05	5	59	2	17546630
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	SIN3A MBD2 MBD3	3.75e-05	38	59	3	33283408
Pubmed	Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo.	MBD2 MBD3	4.23e-05	6	59	2	14643676
Pubmed	RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.	MBD2 MBD3	4.23e-05	6	59	2	17049487
Pubmed	Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.	MBD2 MBD3	4.23e-05	6	59	2	12183469
Pubmed	Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.	AP3B2 AP3B1	4.23e-05	6	59	2	15537701
Pubmed	Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.	SIN3A MBD2	5.91e-05	7	59	2	19729656
Pubmed	Tails of unconventional myosins.	MYO9A MYO15A	5.91e-05	7	59	2	11212352
Pubmed	CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.	MBD2 MBD3	5.91e-05	7	59	2	20523938
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3B2 AP3B1	5.91e-05	7	59	2	9151686
Pubmed	Specific and ubiquitous expression of different Zn finger protein genes in the mouse.	ZNF585A ZNF585B	5.91e-05	7	59	2	3143103
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	SIN3A MBD2 MBD3	6.25e-05	45	59	3	21258344
Pubmed	The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos.	MBD2 MBD3	7.87e-05	8	59	2	23154201
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3B2 AP3B1	7.87e-05	8	59	2	9545220
Pubmed	The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.	MBD2 MBD3	7.87e-05	8	59	2	11297506
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	RPL22 IGF1R SYNJ1 AP3B2 C1QB GRIN1 SLC2A1	8.54e-05	621	59	7	22794259
Pubmed	The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.	L3MBTL2 SIN3A MBD3	9.11e-05	51	59	3	22770845
Pubmed	AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.	AP3B2 AP3B1	1.01e-04	9	59	2	23144738
Pubmed	The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.	FBXO40 IGF1R	1.01e-04	9	59	2	22033112
Pubmed	Identification and functional characterization of the p66/p68 components of the MeCP1 complex.	MBD2 MBD3	1.01e-04	9	59	2	11756549
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	SLC26A5 MYO15A	1.01e-04	9	59	2	19339464
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	L3MBTL2 SIN3A MBD2 MBD3	1.13e-04	146	59	4	23892456
Pubmed	Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.	IGF1R PLXNB2 SLC2A1	1.14e-04	55	59	3	38945485
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	SIN3A NOL9 MBD2 MBD3	1.26e-04	150	59	4	28242625
Pubmed	Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.	MICU3 MICU1	1.26e-04	10	59	2	35302860
Pubmed	Regulation of arrestin-3 phosphorylation by casein kinase II.	AP3B2 AP3B1	1.26e-04	10	59	2	11877451
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3B2 AP3B1	1.26e-04	10	59	2	18076669
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RPL22 ENPP6 AGO1 SYNJ1 MYO9A AP3B2 C1QB GRIN1 AP3B1 SLC2A1	1.35e-04	1431	59	10	37142655
Pubmed	SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.	GRIN1 SLC2A1	1.54e-04	11	59	2	29490264
Pubmed	Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.	AP3B2 AP3B1	1.85e-04	12	59	2	19144828
Pubmed	Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.	MBD2 MBD3	1.85e-04	12	59	2	21937684
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	L3MBTL2 SIN3A MBD2 MBD3	1.90e-04	167	59	4	20362541
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	L3MBTL2 SMCHD1 SIN3A NOL9 MBD2 MBD3	1.92e-04	495	59	6	27705803
Pubmed	Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.	SIN3A MBD3	2.18e-04	13	59	2	16469706
Pubmed	Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes.	MBD2 MBD3	2.18e-04	13	59	2	10441743
Pubmed	A molecular mechanism for circadian clock negative feedback.	SIN3A CLOCK	2.18e-04	13	59	2	21680841
Pubmed	Single cell RT-PCR on mouse embryos: a general approach for developmental biology.	MBD2 MBD3	2.18e-04	13	59	2	20300987
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	RPL22 RBL1 SMCHD1 AP3B2 CERT1 TUBAL3	2.33e-04	513	59	6	25798074
Pubmed	Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.	SIN3A MBD3	2.54e-04	14	59	2	17827154
Pubmed	GATA-1 forms distinct activating and repressive complexes in erythroid cells.	MBD2 MBD3	2.54e-04	14	59	2	15920471
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	MBD2 MBD3	2.54e-04	14	59	2	16428440
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	MBD2 MBD3	2.93e-04	15	59	2	25247294
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	MBD2 MBD3	2.93e-04	15	59	2	19927129
Pubmed	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.	MBD2 MBD3	2.93e-04	15	59	2	15701600
Pubmed	Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.	MBD2 MBD3	3.34e-04	16	59	2	18784354
Pubmed	RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.	MBD2 MBD3	3.34e-04	16	59	2	30760870
Pubmed	Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.	AP3B2 AP3B1	3.34e-04	16	59	2	23247405
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	SIN3A MBD2	3.79e-04	17	59	2	14519686
Pubmed	Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.	MBD2 MBD3	4.25e-04	18	59	2	23201013
Pubmed	Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.	MBD2 MBD3	4.25e-04	18	59	2	16217013
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	AP3B2 AP3B1	4.25e-04	18	59	2	21998198
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	BRIP1 IGF1R CYP2E1 MBD2 SLC2A1	4.35e-04	374	59	5	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	BRIP1 IGF1R CYP2E1 MBD2 SLC2A1	4.74e-04	381	59	5	18676680
Cytoband	1p36.31	RPL22 NOL9	1.46e-04	14	59	2	1p36.31
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	MBD2 MBD3	3.58e-04	11	47	2	1025
GeneFamily	PHD finger proteins\|NuRD complex	MBD2 MBD3	4.29e-04	12	47	2	1305
Coexpression	GSE9037_CTRL_VS_LPS_4H_STIM_BMDM_DN	MICU3 AGO1 MYO9A ENPP2 AP3B1 CLOCK	5.89e-06	200	59	6	M5806
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT_HG-U133A	SYNJ1 ENPP2 ICA1 FNDC3A CERT1 PLK4 MBD3	7.10e-07	195	59	7	1156_UP
Drug	clozapine N-oxide	CYP2E1 SLC6A5 SLC2A1	4.64e-06	13	59	3	CID000036727
Drug	Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A	SYNJ1 ICA1 FNDC3A ADAMTS5 MBD2 PLK4	9.45e-06	189	59	6	1700_UP
Drug	Felbinac [5728-52-9]; Up 200; 18.8uM; MCF7; HT_HG-U133A	CYP2E1 ENPP2 ICA1 PAK5 AGXT MBD3	1.30e-05	200	59	6	5700_UP
Drug	fenarimol	AP3B2 UHMK1 AP3B1 MBD2	1.66e-05	59	59	4	CID000043226
Drug	aminoacetonitrile	CYP2E1 UHMK1 MBD2	2.13e-05	21	59	3	CID000010901
Disease	Alzheimer's disease (is_marker_for)	BRIP1 IGF1R C1QB ELK1 GRIN1 SLC2A1	1.26e-05	257	59	6	DOID:10652 (is_marker_for)
Disease	diabetes mellitus (implicated_via_orthology)	IGF1R ICA1 CLOCK	1.91e-05	26	59	3	DOID:9351 (implicated_via_orthology)
Disease	Severe Congenital Microcephaly	SIN3A PLK4 SLC2A1	3.28e-05	31	59	3	C3853041
Disease	Microlissencephaly	SIN3A PLK4 SLC2A1	3.97e-05	33	59	3	C1956147
Disease	morbid obesity (is_marker_for)	CYP2E1 ACSS2	1.75e-04	10	59	2	DOID:11981 (is_marker_for)
Disease	Alcoholic Intoxication, Chronic	AGO1 CYP2E1 GRIN1 CLOCK PCDH10	2.00e-04	268	59	5	C0001973
Disease	sleep disorder (implicated_via_orthology)	IGF1R CLOCK	2.14e-04	11	59	2	DOID:535 (implicated_via_orthology)
Disease	Microcephaly	SIN3A PLK4 SLC2A1	3.32e-04	67	59	3	C0025958
Disease	anthropometric measurement	IGF1R ADAMTS5 AP3B1 TENM2	3.62e-04	168	59	4	EFO_0004302
Disease	Lewy body dementia (is_marker_for)	IGF1R ELK1	6.58e-04	19	59	2	DOID:12217 (is_marker_for)
Disease	interleukin-2 receptor subunit alpha measurement	SLC6A5 TUBAL3	8.05e-04	21	59	2	EFO_0010587
Disease	lung cancer	BRIP1 TENM2	8.05e-04	21	59	2	MONDO_0008903
Disease	middle cerebral artery infarction (biomarker_via_orthology)	CYP2E1 GRIN1 SLC2A1	8.67e-04	93	59	3	DOID:3525 (biomarker_via_orthology)
Disease	carnosine measurement	AP3B1 TENM2	1.05e-03	24	59	2	EFO_0010470
Disease	Dwarfism	SIN3A PLK4	1.14e-03	25	59	2	C0013336
Disease	Epileptic encephalopathy	GRIN1 SLC2A1	1.65e-03	30	59	2	C0543888
Disease	Autistic Disorder	FBXO40 AGO1 PCDH10 MBD3	1.86e-03	261	59	4	C0004352
Disease	Intellectual Disability	AGO1 SIN3A GRIN1 CERT1 SLC2A1	1.99e-03	447	59	5	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
VSGQKFVYKFVSYPE	ELK1	76	P19419
AKGTGYYVVFSPKVT	ADAMTS5	671	Q9UNA0
FYKSTRFKPTRIIFY	AGO1	651	Q9UL18
YKVTKFYTAPTAIRL	ACSS2	401	Q9NR19
GMFEPYLKSFYVRST	AP3B1	366	O00203
GMFEPYLKSFYIRST	AP3B2	371	Q13367
FKYSDYFKPFSTGKR	CYP2E1	421	P05181
PRKYLYVTSSFKGAF	MORC1	271	Q86VD1
EYPKFLKRFTSYVQE	CERT1	601	Q9Y5P4
YYSEVKPLKSDFARF	PAK5	181	Q9P286
KYVFSAYKRESPLIV	NOL9	391	Q5SY16
FYSTLIFTYLKPRKS	OR8H2	251	Q8N162
NYKRYFPVIFGKASE	MAGEA9	141	P43362
RDVFYYSPSGKKFRS	MBD3	31	O95983
IFTYFKVPETKGRTF	SLC2A1	446	P11166
VPYLFKKVRAVYTEG	L3MBTL2	411	Q969R5
IFLRKEVFYPKDSYS	MYO15A	2691	Q9UKN7
KFRIPYLGVYVFKYT	MMRN1	1136	Q13201
ISFTVYYKEAPFKNV	IGF1R	521	P08069
YSTPDKIFRYFATLK	MICU1	121	Q9BPX6
DYKTYTDRVFFLPSK	PLXNB2	1276	O15031
TFRISNYFKYVPLKT	DNAH12	1746	Q6ZR08
GFRGYKTVQKYPTFK	MICU3	506	Q86XE3
VPFRLKSSFKNYYTI	PCDH10	401	Q9P2E7
SEYTIGGVKIYFPYK	BRIP1	6	Q9BX63
DVYYFSPSGKKFRSK	MBD2	176	Q9UBB5
EFKQIYKGPDSSFRY	FNDC3A	1091	Q9Y2H6
RSGKFTCKVPGLYYF	C1QB	156	P02746
TVYTFKVPVSYCGKR	FBXO40	346	Q9UH90
TRRYYKEKFGITDLP	EFHC1	351	Q5JVL4
QKAGIRAYPTVKFYF	DNAJC10	736	Q8IXB1
SRFYYKKGKFVSPLT	ENPP6	306	Q6UWR7
YGSTFKYKTKVPPFE	ENPP2	491	Q13822
FKGYQPYEFTTLKSL	ICA1	256	Q05084
KKFFTGYLDTPVVSY	RSPH6A	456	Q9H0K4
YSRKTKPFSFYLDIK	AGXT	231	P21549
FYFRDKVIPNKVGTY	SMCHD1	1446	A6NHR9
GKVTFAPTYKYDLFS	SYNJ1	776	O43426
KTSGKVVYFTATFPY	SLC6A5	416	Q9Y345
IKFYNTIYVGRVKSF	RBL1	931	P28749
GVKTKRYSGIFSVVY	SLC26A5	231	P58743
ERPKGFYVETVVTYK	SMIM26	56	A0A096LP01
FVSINKYRVKYGTVF	SIN3A	1256	Q96ST3
FVKYPKYGYTITRQD	TENM2	951	Q9NT68
GEYSRKTKLEFSVYP	TUBAL3	166	A6NHL2
VRSKSPKITYFTRYA	PLK4	696	O00444
PYITRYFGSYLKSTK	STK25	76	O00506
EPSTYEYVKFIGNFK	CLOCK	206	O15516
KEFRSIKTYTGPFVY	SPATA2	106	Q9UM82
GTTLFFYTDKKSIIY	STAP1	51	Q9ULZ2
TRVKPYICTEYGKVF	ZNF585B	321	Q52M93
TVTSEVPFSKRYLKY	RPL22	71	P35268
TRVKPYICTEYGKVF	ZNF585A	321	Q6P3V2
EAKTKYPGSYLTFEV	XPNPEP2	576	O43895
SGKVVYFTALFPYVV	SLC6A14	261	Q9UN76
LYYVFDKFILTSGKP	TUT4	896	Q5TAX3
GKFVVATFYPLSAYK	UHMK1	396	Q8TAS1
GTRKLFQIYSKSPFY	MYO9A	2446	B2RTY4
YIEFSKPFKYQGLTI	GRIN1	526	Q05586