Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	RELCH DOCK8 INTS1 PUM2 ZYG11B PPP6R1 HUWE1 WDFY4 LYST RIF1 NF1 MMS19 PUM1 PPP6R3	1.39e-08	339	111	14	IPR016024
Domain	ARM-like	RELCH SETX DOCK8 PUM2 ZYG11B HUWE1 WDFY4 RIF1 NF1 MMS19 PUM1 PPP6R3	7.23e-08	270	111	12	IPR011989
Domain	ACTININ_2	SPTBN5 CLMN MACF1 UTRN	9.59e-06	23	111	4	PS00020
Domain	ACTININ_1	SPTBN5 CLMN MACF1 UTRN	9.59e-06	23	111	4	PS00019
Domain	Actinin_actin-bd_CS	SPTBN5 CLMN MACF1 UTRN	9.59e-06	23	111	4	IPR001589
Domain	Spectrin_repeat	PPL SPTBN5 MACF1 UTRN	2.50e-05	29	111	4	IPR002017
Domain	Pumilio_RNA-bd	PUM2 PUM1	3.50e-05	2	111	2	IPR033712
Domain	SPEC	PPL SPTBN5 MACF1 UTRN	3.74e-05	32	111	4	SM00150
Domain	Spectrin/alpha-actinin	PPL SPTBN5 MACF1 UTRN	3.74e-05	32	111	4	IPR018159
Domain	-	RELCH PUM2 ZYG11B WDFY4 RIF1 NF1 MMS19 PUM1	5.43e-05	222	111	8	1.25.10.10
Domain	CH	SPTBN5 CLMN MACF1 MAPRE2 UTRN	6.03e-05	70	111	5	PF00307
Domain	-	SPTBN5 CLMN MACF1 MAPRE2 UTRN	6.45e-05	71	111	5	1.10.418.10
Domain	CH	SPTBN5 CLMN MACF1 MAPRE2 UTRN	7.37e-05	73	111	5	PS50021
Domain	CH-domain	SPTBN5 CLMN MACF1 MAPRE2 UTRN	8.39e-05	75	111	5	IPR001715
Domain	PUF	PUM2 PUM1	1.05e-04	3	111	2	PF00806
Domain	SAPS	PPP6R1 PPP6R3	1.05e-04	3	111	2	IPR007587
Domain	PUM_HD	PUM2 PUM1	1.05e-04	3	111	2	PS50303
Domain	PUM-HD	PUM2 PUM1	1.05e-04	3	111	2	IPR033133
Domain	SAPS	PPP6R1 PPP6R3	1.05e-04	3	111	2	PF04499
Domain	PUM	PUM2 PUM1	2.08e-04	4	111	2	PS50302
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	2.08e-04	4	111	2	IPR001313
Domain	Pumilio	PUM2 PUM1	2.08e-04	4	111	2	SM00025
Domain	Spectrin	SPTBN5 MACF1 UTRN	3.32e-04	23	111	3	PF00435
Domain	CH	SPTBN5 CLMN MACF1 UTRN	6.05e-04	65	111	4	SM00033
Domain	Munc13_1	UNC13D CADPS	7.21e-04	7	111	2	IPR014770
Domain	MHD1	UNC13D CADPS	7.21e-04	7	111	2	PS51258
Domain	Plectin	PPL MACF1	7.21e-04	7	111	2	PF00681
Domain	DUF1041	UNC13D CADPS	7.21e-04	7	111	2	PF06292
Domain	Plectin_repeat	PPL MACF1	7.21e-04	7	111	2	IPR001101
Domain	CAPS_dom	UNC13D CADPS	7.21e-04	7	111	2	IPR010439
Domain	PLEC	PPL MACF1	7.21e-04	7	111	2	SM00250
Domain	Abhydrolase_1	SERHL2 SERHL LIPJ	8.13e-04	31	111	3	PF00561
Domain	PH-BEACH_dom	WDFY4 LYST	9.57e-04	8	111	2	IPR023362
Domain	-	WDFY4 LYST	9.57e-04	8	111	2	2.30.29.40
Domain	PH_BEACH	WDFY4 LYST	9.57e-04	8	111	2	PS51783
Domain	AB_hydrolase_1	SERHL2 SERHL LIPJ	9.79e-04	33	111	3	IPR000073
Domain	PH_dom-spectrin-type	SPTBN5 PSD4	1.23e-03	9	111	2	IPR001605
Domain	BEACH	WDFY4 LYST	1.23e-03	9	111	2	PS50197
Domain	Beach	WDFY4 LYST	1.23e-03	9	111	2	PF02138
Domain	-	WDFY4 LYST	1.23e-03	9	111	2	1.10.1540.10
Domain	Beach	WDFY4 LYST	1.23e-03	9	111	2	SM01026
Domain	BEACH_dom	WDFY4 LYST	1.23e-03	9	111	2	IPR000409
Domain	PNT	ETV7 ETV6	1.86e-03	11	111	2	PS51433
Domain	SAM_PNT	ETV7 ETV6	1.86e-03	11	111	2	PF02198
Domain	Pointed_dom	ETV7 ETV6	1.86e-03	11	111	2	IPR003118
Domain	SAM_PNT	ETV7 ETV6	1.86e-03	11	111	2	SM00251
Domain	zf-C2H2	ZNF131 ZNF765 ZBTB43 YY1 ZFPM2 BNC1 PRDM10 ZNF878 ZNF335 ZNF761 ZNF639	2.78e-03	693	111	11	PF00096
Domain	Ldl_recept_b	LRP8 NID1	3.04e-03	14	111	2	PF00058
Domain	LDLRB	LRP8 NID1	3.04e-03	14	111	2	PS51120
Domain	LY	LRP8 NID1	3.49e-03	15	111	2	SM00135
Domain	LDLR_classB_rpt	LRP8 NID1	3.49e-03	15	111	2	IPR000033
Domain	PH_dom-like	ARHGEF28 WDFY4 LYST SPTBN5 PTPN13 CADPS ARHGEF3 PSD4	3.92e-03	426	111	8	IPR011993
Domain	Cadherin_CS	PCDHGA7 FAT1 DCHS1 PCDH18	4.07e-03	109	111	4	IPR020894
Domain	CADHERIN_1	PCDHGA7 FAT1 DCHS1 PCDH18	4.63e-03	113	111	4	PS00232
Domain	Cadherin	PCDHGA7 FAT1 DCHS1 PCDH18	4.63e-03	113	111	4	PF00028
Domain	CADHERIN_2	PCDHGA7 FAT1 DCHS1 PCDH18	4.78e-03	114	111	4	PS50268
Domain	-	PCDHGA7 FAT1 DCHS1 PCDH18	4.78e-03	114	111	4	2.60.40.60
Domain	CA	PCDHGA7 FAT1 DCHS1 PCDH18	4.93e-03	115	111	4	SM00112
Domain	Cadherin-like	PCDHGA7 FAT1 DCHS1 PCDH18	5.08e-03	116	111	4	IPR015919
Domain	Cadherin	PCDHGA7 FAT1 DCHS1 PCDH18	5.40e-03	118	111	4	IPR002126
Domain	PA	RNF128 RNF133	5.60e-03	19	111	2	PF02225
Domain	PA_domain	RNF128 RNF133	5.60e-03	19	111	2	IPR003137
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	VIM ZNF131 PUM2 CCDC50 PPP6R1 OCRL USP16 NEK1 RIF1 PTPN13 CLMN MLH1 MACF1 MAPRE2 UTRN CPSF3 PPP6R3	1.44e-08	934	116	17	33916271
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DMTF1 SETX CNTRL LGR4 CCDC50 UNC13D HUWE1 UBN2 WDFY4 KMT2C PTPN13 CLMN MACF1 SDF4 ARHGEF3 PUM1 UTRN PCDH18	2.12e-08	1084	116	18	11544199
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	VIM RELCH ZYG11B PPP6R1 HUWE1 CEP350 RIF1 PTPN13 CEP89 MLH1 SDF4 PUM1 MAPRE2 UTRN YME1L1 CPSF3 PPP6R3	7.71e-08	1049	116	17	27880917
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	VIM SETX DOCK8 INTS1 HUWE1 RIF1 SF3B3 NF1 MDN1 BUB1 MLH1 MACF1 CPSF3	8.07e-08	582	116	13	20467437
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PUM2 CCDC50 ZDBF2 HUWE1 TMEM9B YY1 CEP350 CLMN BANP STEAP3 SDF4 PUM1 MAPRE2 CPSF3	1.69e-07	733	116	14	34672954
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ZDBF2 PPP6R1 CEP350 NEK1 PTPN13 MACF1 UTRN PPP6R3	5.42e-07	209	116	8	36779422
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	VIM SETX OCRL HUWE1 IDH3B USP16 RIF1 SF3B3 NF1 MDN1 MLH1 MACF1 MMS19 PUM1 MAPRE2 UTRN YME1L1 CPSF3	5.65e-07	1353	116	18	29467282
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	VIM SETX ARHGEF28 LYST CEP350 NEK1 PTPN13 NF1 MDN1 CEP89 CLMN MACF1 PUM1 UTRN	1.15e-06	861	116	14	36931259
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	VIM ZNF131 NRIP1 ZDBF2 PPP6R1 HUWE1 NEK1 PTPN13 BUB1 UTRN	1.48e-06	418	116	10	34709266
Pubmed	Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.	VIM PPP6R1 PPP6R3	2.00e-06	8	116	3	16769727
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	VIM SETX CNTRL LGR4 OCRL HUWE1 PPL CEP350 RIF1 FAT1 PTPN13 BRCA1 STEAP3	2.08e-06	777	116	13	35844135
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NRIP1 SETX ZDBF2 PPP6R1 HUWE1 UBN2 SF3B3 BUB1 BANP MACF1 PPP6R3	4.66e-06	588	116	11	38580884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LGR4 PPP6R1 IDH3B YY1 FAT1 SF3B3 BRCA1 CADPS CAPRIN2 MLH1 MACF1 SDF4 MMS19 YME1L1 UNC80	4.79e-06	1116	116	15	31753913
Pubmed	Functional proteomics mapping of a human signaling pathway.	DMTF1 DOCK8 LAMA4 HUWE1 PIR PPL MACF1 NID1 SDF4 PUM1 UTRN	4.89e-06	591	116	11	15231748
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	HUWE1 CEP350 MDN1 MACF1 UTRN	5.79e-06	76	116	5	27542412
Pubmed	Defining the membrane proteome of NK cells.	DOCK8 CNTRL INTS1 HUWE1 LRP8 CEP350 NF1 MDN1 BUB1 PEX16 MLH1 SDF4 MMS19 YME1L1 PSD4	8.25e-06	1168	116	15	19946888
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	HUWE1 PTPN13 NF1 NID1 MMS19 UTRN CPSF3 PPP6R3	1.08e-05	313	116	8	38270169
Pubmed	BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.	SETX BRCA1	1.10e-05	2	116	2	25699710
Pubmed	Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.	SERHL2 SERHL	1.10e-05	2	116	2	11352564
Pubmed	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.	HUWE1 BRCA1	1.10e-05	2	116	2	24342616
Pubmed	RIF1 counteracts BRCA1-mediated end resection during DNA repair.	RIF1 BRCA1	1.10e-05	2	116	2	23486525
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	1.10e-05	2	116	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	1.10e-05	2	116	2	29165587
Pubmed	Binding of the periplakin linker requires vimentin acidic residues D176 and E187.	VIM PPL	1.10e-05	2	116	2	32081916
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	1.10e-05	2	116	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	1.10e-05	2	116	2	26517885
Pubmed	RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1.	BRCA1 MLH1	1.10e-05	2	116	2	15300854
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	1.10e-05	2	116	2	12667987
Pubmed	Clinical significance of epigenetic inactivation of hMLH1 and BRCA1 in Tunisian patients with invasive breast carcinoma.	BRCA1 MLH1	1.10e-05	2	116	2	19644562
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	1.10e-05	2	116	2	31078383
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	1.10e-05	2	116	2	32753408
Pubmed	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.	HUWE1 BRCA1	1.10e-05	2	116	2	24472556
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	1.10e-05	2	116	2	32437472
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	1.10e-05	2	116	2	32316190
Pubmed	A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.	HUWE1 BRCA1	1.10e-05	2	116	2	37491606
Pubmed	Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation.	YY1 BRCA1	1.10e-05	2	116	2	21666725
Pubmed	Complementation of the beige mutation in cultured cells by episomally replicating murine yeast artificial chromosomes.	LYST NID1	1.10e-05	2	116	2	8650191
Pubmed	Germline mutations in NF1 and BRCA1 in a family with neurofibromatosis type 1 and early-onset breast cancer.	NF1 BRCA1	1.10e-05	2	116	2	23624750
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	1.10e-05	2	116	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	1.10e-05	2	116	2	21397187
Pubmed	In vitro analysis of genomic instability triggered by BRCA1 missense mutations.	BRCA1 MLH1	1.10e-05	2	116	2	16786532
Pubmed	Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6.	ETV7 ETV6	1.10e-05	2	116	2	11108721
Pubmed	Identification of the homologous beige and Chediak-Higashi syndrome genes.	LYST NID1	1.10e-05	2	116	2	8717042
Pubmed	The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.	NF1 BRCA1	1.10e-05	2	116	2	8566965
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	1.10e-05	2	116	2	35338151
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	1.10e-05	2	116	2	18776931
Pubmed	Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.	NF1 MLH1	1.10e-05	2	116	2	12881715
Pubmed	Identification of the murine beige gene by YAC complementation and positional cloning.	LYST NID1	1.10e-05	2	116	2	8673129
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGEF28 DOCK8 CCDC50 OCRL HUWE1 YY1 RIF1 ARHGEF3 MAPRE2 UTRN YME1L1 CPSF3 PPP6R3	1.22e-05	916	116	13	32203420
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	VIM CCDC50 HUWE1 MACF1 SDF4 UTRN PPP6R3	1.47e-05	235	116	7	28378594
Pubmed	Tagging genes with cassette-exchange sites.	RELCH PUM2 KMT2C RIF1 MACF1 MMS19 PUM1 PPP6R3	1.76e-05	335	116	8	15741177
Pubmed	The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.	ZNF131 YY1 PRDM10	1.96e-05	16	116	3	20805357
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	DOCK8 PPP6R1 PTPN13 NF1 CEP89 MOB1B PUM1 UTRN PPP6R3	1.97e-05	446	116	9	24255178
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ZBTB43 INTS1 ZYG11B CEP350 KMT2C NEK1 FAT1 MDN1 CLMN ZNF335 MMS19	2.04e-05	689	116	11	36543142
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZDBF2 HUWE1 WDFY4 PCDH18 PPP6R3	2.32e-05	101	116	5	10997877
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 PTPN13 NF1 MDN1 YME1L1	2.67e-05	104	116	5	31240132
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ZNF131 SETX PPP6R1 HUWE1 YY1 RIF1 PRDM10 MDN1 BANP MMS19 PUM1 FOXG1	3.07e-05	857	116	12	25609649
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	3.30e-05	3	116	2	30333515
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	3.30e-05	3	116	2	25340845
Pubmed	[Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells].	BRCA1 MLH1	3.30e-05	3	116	2	18683754
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	3.30e-05	3	116	2	26724866
Pubmed	Neurofibromatosis with male breast cancer--risk factor or co-incidence? Report of two rare cases.	NF1 BRCA1	3.30e-05	3	116	2	25267367
Pubmed	Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome 13 linked to beige (bg) and identifies a new region of homology between mouse and human chromosomes.	LYST NID1	3.30e-05	3	116	2	1672300
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	3.30e-05	3	116	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	3.30e-05	3	116	2	27157388
Pubmed	The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).	ETV7 ETV6	3.30e-05	3	116	2	12588862
Pubmed	New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.	NRIP1 MACF1	3.30e-05	3	116	2	33036707
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	3.30e-05	3	116	2	28232582
Pubmed	OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses.	OCRL LRP8	3.30e-05	3	116	2	39062513
Pubmed	Prediction of BRCA1 germ-line mutation status in patients with breast cancer using histoprognosis grade, MS110, Lys27H3, vimentin, and KI67.	VIM BRCA1	3.30e-05	3	116	2	23614934
Pubmed	Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients.	VIM MLH1	3.30e-05	3	116	2	19617759
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	3.30e-05	3	116	2	38427913
Pubmed	Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model.	NF1 BRCA1	3.30e-05	3	116	2	37207276
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	3.30e-05	3	116	2	22345517
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETX INTS1 ETV6 PUM2 CCDC50 UBN2 KMT2C RIF1 PTPN13 MDN1 BRCA1 MLH1 MACF1 UTRN YME1L1 PPP6R3	3.84e-05	1497	116	16	31527615
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	NRIP1 TRAF1 PPFIA4 IDH3B PPL ZFPM2 CEP350 BRCA1 PUM1 ZNF639	3.84e-05	608	116	10	16713569
Pubmed	MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.	PPP6R1 PTPN13 MACF1 PPP6R3	4.05e-05	57	116	4	29089450
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGEF28 PPFIA4 UBN2 WDFY4 CEP350 NEK1 MACF1 PCDH18 UNC80	4.29e-05	493	116	9	15368895
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	INTS1 ETV6 ZDBF2 PPP6R1 MDN1 MACF1 MMS19	4.70e-05	282	116	7	23667531
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MDM1 ETV6 PPP6R1 HUWE1 RIF1 MDN1 PPP6R3	5.48e-05	289	116	7	23752268
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NRIP1 MXRA5 ZDBF2 IDH3B CEP350 RAD51AP2 NF1 MDN1 ADAMTS6 YME1L1	5.74e-05	638	116	10	31182584
Pubmed	ABCE1 is a highly conserved RNA silencing suppressor.	VIM MDN1 MACF1 SDF4 MMS19 CPSF3	6.57e-05	204	116	6	25659154
Pubmed	Binding of protein kinase B to the plakin family member periplakin.	VIM PPL	6.59e-05	4	116	2	12244133
Pubmed	Pathological MAPK activation-mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib.	LAMA4 NID1	6.59e-05	4	116	2	36073544
Pubmed	Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation.	BRCA1 MLH1	6.59e-05	4	116	2	35205366
Pubmed	Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.	RIF1 BRCA1	6.59e-05	4	116	2	27494840
Pubmed	Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.	BRCA1 MLH1	6.59e-05	4	116	2	19383374
Pubmed	Role of the Rho GTPase-activating protein RICS in neurite outgrowth.	PPP6R1 PPP6R3	6.59e-05	4	116	2	16716191
Pubmed	Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.	PPP6R1 PPP6R3	6.59e-05	4	116	2	19621075
Pubmed	The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.	LYST NID1	6.59e-05	4	116	2	9070932
Pubmed	Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.	BRCA1 MLH1	6.59e-05	4	116	2	20173781
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	6.59e-05	4	116	2	30811992
Pubmed	Methylation biomarkers for pleomorphic lobular breast cancer - a short report.	BRCA1 MLH1	6.59e-05	4	116	2	26392358
Pubmed	Predictive value of MGMT, hMLH1, hMSH2 and BRCA1 protein expression for pathological complete response to neoadjuvant chemotherapy in basal-like breast cancer patients.	BRCA1 MLH1	6.59e-05	4	116	2	22083523
Pubmed	Positional cloning of the Chediak-Higashi syndrome gene: genetic mapping of the beige locus on mouse chromosome 13.	LYST NID1	6.59e-05	4	116	2	8952226
Pubmed	The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.	BRCA1 MLH1	6.59e-05	4	116	2	17581638
Pubmed	A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.	RIF1 BRCA1	6.59e-05	4	116	2	23333306
Pubmed	Studies on selected molecular factors in endometrial cancers.	BRCA1 MLH1	6.59e-05	4	116	2	30277666
Pubmed	53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.	RIF1 BRCA1	6.59e-05	4	116	2	23727112
Pubmed	The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).	ETV6 PTPN13	6.59e-05	4	116	2	22262849
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF131 ZNF765 ZBTB43 YY1 ZFPM2 BNC1 PRDM10 ZNF878 ZNF335 ZNF761 ZNF639	1.05e-04	718	71	11	28
GeneFamily	Protein phosphatase 6 regulatory subunits	PPP6R1 PPP6R3	2.26e-04	6	71	2	699
GeneFamily	EF-hand domain containing\|Plakins	PPL MACF1	4.19e-04	8	71	2	939
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY4 LYST	5.38e-04	9	71	2	1230
GeneFamily	Cadherin related	FAT1 DCHS1	1.99e-03	17	71	2	24
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	DOCK8 CEP350 KMT2C RIF1 PRDM10 NF1 BRCA1 MACF1 UTRN	1.05e-07	180	115	9	M8239
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	DMTF1 VIM TRAF1 SETX DOCK8 CNTRL PUM2 UNC13D PPP6R1 HUWE1 LYST CEP350 KMT2C RIF1 SF3B3 GVINP1 MACF1 ARHGEF3 MAPRE2 UTRN YME1L1 MRFAP1L1 PSD4	1.15e-07	1492	115	23	M40023
Coexpression	GSE22103_LPS_VS_GMCSF_AND_IFNG_STIM_NEUTROPHIL_UP	RELCH ETV6 CMYA5 LRP8 ADAMTS6 BUB1 CAPRIN2 UTRN	2.94e-06	200	115	8	M7795
Coexpression	GSE27786_NKTCELL_VS_MONO_MAC_UP	INTS1 HUWE1 IDH3B UBN2 YY1 LYST MLH1	2.96e-05	200	115	7	M4870
Coexpression	GSE15750_DAY6_VS_DAY10_EFF_CD8_TCELL_DN	TRAF1 CYP2E1 KMT2C SF3B3 MDN1 MLH1 NR1D2	2.96e-05	200	115	7	M3579
Coexpression	GSE3982_NEUTROPHIL_VS_CENT_MEMORY_CD4_TCELL_DN	TRAF1 CYP2E1 USP16 CAPRIN2 ARHGEF3 PUM1 MAPRE2	2.96e-05	200	115	7	M5529
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	SETX CNTRL MDM1 PUM2 CCDC50 ZDBF2 PIR UBN2 USP16 BCLAF3 CEP350 RIF1 MDN1 BRCA1 MOB1B BUB1 MLH1 MACF1 ZNF761 RNF128	1.11e-05	1257	114	20	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	SETX CNTRL MDM1 PUM2 CCDC50 ZDBF2 PIR UBN2 USP16 LRP8 BCLAF3 CEP350 RIF1 MDN1 BRCA1 MOB1B BUB1 MLH1 MACF1 ZNF761 RNF128	2.93e-05	1459	114	21	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	SETX ZBTB43 BCLAF3 RIF1 SF3B3 MDN1 BRCA1 BUB1 NR1D2	7.88e-05	333	114	9	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	RELCH SETX ARHGEF28 CNTRL CCDC50 OCRL CEP350 NEK1 RIF1	9.03e-05	339	114	9	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000	RELCH SETX MAOA LAMA4 CCDC50 IRF6 HUWE1 LRP8 CEP350 NEK1 RIF1 CADPS TWSG1 PCDH18	1.25e-04	818	114	14	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	RELCH SETX HUWE1 LYST BCLAF3 KMT2C NEK1 RIF1 SF3B3 MDN1 BRCA1 BUB1 CAPRIN2 NR1D2	1.28e-04	820	114	14	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000	RELCH LAMA4 CCDC50 OCRL CEP350 TWSG1 UTRN	1.37e-04	209	114	7	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	RELCH SETX CCDC50 HUWE1 DNAJC22 RIF1	1.38e-04	146	114	6	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX DOCK8 PPFIA4 CNTRL CCDC50 LYST CEP350 MACF1 UTRN	1.38e-09	184	116	9	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TRAF1 HUWE1 KMT2C NF1 MACF1 MAPRE2 UTRN	6.32e-07	188	116	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 CMYA5 SLC16A12 PTPN13 CLMN PKHD1	7.53e-07	193	116	7	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 CMYA5 SLC16A12 FAT1 PTPN13 PKHD1	7.53e-07	193	116	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 SLC16A12 FAT1 PTPN13 CLMN PKHD1	7.80e-07	194	116	7	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HUWE1 RAD51AP2 KMT2C RIF1 CADPS MACF1 UNC80	8.07e-07	195	116	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HUWE1 RAD51AP2 KMT2C RIF1 CADPS MACF1 UNC80	8.07e-07	195	116	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VIM TRAF1 ACRBP DOCK8 ETV6 CCDC50 WDFY4	8.94e-07	198	116	7	b2c8d5956f8449df4b69fb1b30632253440f815e
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VIM LAMA4 ABCA10 SLC16A12 ZFPM2 PTPN13 NID1	9.24e-07	199	116	7	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TRAF1 MOGAT2 IRF6 PPL GVINP1	5.03e-06	95	116	5	53dde5363ea1d64386234e5bd4fbb28c057f2f21
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TRAF1 MOGAT2 IRF6 PPL GVINP1	5.03e-06	95	116	5	ef0b7289b348617a76b4643479adc7e9701c0094
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TRAF1 MOGAT2 IRF6 PPL GVINP1	5.03e-06	95	116	5	8b4d6b25ce28811a76ea11713d881117e495ef5e
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SERHL2 C6orf52 CEP350 PRDM10 CLMN BUB1	5.24e-06	168	116	6	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SERHL2 C6orf52 CEP350 PRDM10 CLMN BUB1	5.24e-06	168	116	6	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 CNTRL CCDC50 LYST CEP350 MACF1	8.28e-06	182	116	6	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLDN22 PIR SLC16A12 PPL PTPN13 RPTN	8.54e-06	183	116	6	514b72a1ae55656934839800513385e19bc240e2
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 CNTRL CCDC50 LYST CEP350 MACF1	9.09e-06	185	116	6	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 UNC13D PPL PTPN13 PKHD1 UTRN	9.66e-06	187	116	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 CCDC50 LYST ABCA10 PPL PKHD1	9.66e-06	187	116	6	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ARHGEF28 LGR4 LYST ADAMTS6 CLMN PKHD1	9.66e-06	187	116	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 BNC1 NID1 UTRN	9.66e-06	187	116	6	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 BNC1 NID1 UTRN	9.66e-06	187	116	6	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 BNC1 NID1 UTRN	9.66e-06	187	116	6	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 ETV7 LAMA4 FAT1 RNF128 PCDH18	9.96e-06	188	116	6	ed92cddf47defea2f904d36c7ae05ffa323349a9
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	MXRA5 LAMA4 PM20D1 CMYA5 ZFPM2 BNC1	1.03e-05	189	116	6	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMA4 ABCA10 SLC16A12 ZFPM2 MACF1 NID1	1.09e-05	191	116	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LAMA4 ABCA10 SLC16A12 ZFPM2 MACF1 NID1	1.12e-05	192	116	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 CLDN22 PPL CLMN PKHD1	1.19e-05	194	116	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 CMYA5 SLC16A12 FAT1 PKHD1	1.19e-05	194	116	6	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 SLC16A12 FAT1 PTPN13 PKHD1	1.19e-05	194	116	6	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 LGR4 PPL FAT1 PTPN13 PKHD1	1.26e-05	196	116	6	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MXRA5 LAMA4 ABCA10 SLC16A12 NID1 PCDH18	1.26e-05	196	116	6	12d9028f90c057c6e5cff00301793fa550e86c5a
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MXRA5 ETV7 LAMA4 FAT1 PTPN13 RNF128	1.30e-05	197	116	6	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	NRIP1 CNTRL USP16 CEP350 PTPN13 UTRN	1.34e-05	198	116	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	NRIP1 SETX CNTRL YY1 USP16 CEP350	1.38e-05	199	116	6	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	NRIP1 SETX CNTRL YY1 USP16 CEP350	1.38e-05	199	116	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VIM LAMA4 ABCA10 ZFPM2 PTPN13 NID1	1.38e-05	199	116	6	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIM MXRA5 LAMA4 NID1 TWSG1 PCDH18	1.38e-05	199	116	6	a697b3f0760e66bad8ea8d83cf6fea5934692c56
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LAMA4 CMYA5 ZFPM2 FAT1 NID1 PCDH18	1.38e-05	199	116	6	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 ETV6 KMT2C NF1 UTRN PPP6R3	1.38e-05	199	116	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SETX DOCK8 CEP350 KMT2C MACF1 UTRN	1.41e-05	200	116	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SETX HUWE1 MACF1 ARHGEF3 UTRN PSD4	1.41e-05	200	116	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NRIP1 LAMA4 TNNI3K DCHS1 PCDH18	2.87e-05	136	116	5	e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CMYA5 ABCA10 LRP8 PRDM10 CEP89	3.90e-05	145	116	5	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS CLMN NID1 UTRN PCDH18	5.20e-05	154	116	5	b6e982e341c6cfb6ff80a318078fcb10c36d182f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS CLMN NID1 UTRN PCDH18	5.20e-05	154	116	5	d76fd51a4587decbfe1dde1c8a9b880c5fa18e4a
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2E1 PIR CLMN RNF128 NR1D2	6.23e-05	160	116	5	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA4 ZFPM2 DCHS1 UTRN PCDH18	6.42e-05	161	116	5	bf70be1de418615b5442ec684552551edaf1f072
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA4 TNNI3K DCHS1 UTRN PCDH18	6.42e-05	161	116	5	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	metastatic_Brain-B_lymphocytes-Undetermined\|metastatic_Brain / Location, Cell class and cell subclass	SERHL2 TRAF1 DOCK8 CCDC50 ADAMTS6	6.81e-05	163	116	5	4eac7fd8acdb7f09ce739335f22a879f9b8febfb
ToppCell	VE-Treg-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	MDM1 OCRL CMYA5 PTPN13 PPP6R3	7.63e-05	167	116	5	1036ac1ef9440612500137af9d1929672b077e4d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAF1 PPP6R1 NEK1 ZNF761 ARHGEF3	7.85e-05	168	116	5	ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MXRA5 CLDN22 PTPN13 NID1 PCDH18	9.26e-05	174	116	5	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ARHGEF28 LGR4 ADAMTS6 CLMN ARHGEF3	9.77e-05	176	116	5	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ETV7 ETV6 CCDC50 LYST PTPN13	9.77e-05	176	116	5	56c055488e34605d32562571a2fee621b47c9441
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMYA5 LYST CEP350 MACF1 PCDH18	9.77e-05	176	116	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 NID1 UTRN	1.00e-04	177	116	5	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 NID1 UTRN	1.00e-04	177	116	5	66ffa279147961080c104242a08b176e301d80e3
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIM LAMA4 ZFPM2 NID1 UTRN	1.00e-04	177	116	5	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTRL YY1 LYST GVINP1 UTRN	1.03e-04	178	116	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	T_cells-TFH-like_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	TRAF1 ETV7 ETV6 CCDC50 PTPN13	1.03e-04	178	116	5	e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CNTRL DNAJC22 CEP350 BUB1 MAP3K19	1.06e-04	179	116	5	d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CNTRL DNAJC22 CEP350 BUB1 MAP3K19	1.06e-04	179	116	5	e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 UNC13D PTPN13 RNF128 PSD4	1.09e-04	180	116	5	b28363626f4d2a552abde3434cc1df2e2121aba5
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	ETV7 LAMA4 ZFPM2 BNC1 FAT1	1.09e-04	180	116	5	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF1 UNC13D PTPN13 RNF128 PSD4	1.09e-04	180	116	5	67b062f2ef7e20f392e00c646f4985c415d40de9
ToppCell	(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	TRAF1 CNTRL ETV7 CCDC50 WDFY4	1.11e-04	181	116	5	ad14c7111d4fb924afd233cb114447f195373a7c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LGR4 CCDC50 LYST ABCA10 PPL	1.14e-04	182	116	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ETV7 PPL CADPS RNF128 UNC80	1.17e-04	183	116	5	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	ETV7 CEP350 KMT2C RIF1 UTRN	1.17e-04	183	116	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	ETV7 LAMA4 ZFPM2 BNC1 FAT1	1.17e-04	183	116	5	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 WDFY4 LYST BUB1 PSD4	1.17e-04	183	116	5	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA4 ABCA10 ZFPM2 NID1 PCDH18	1.20e-04	184	116	5	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	MXRA5 LAMA4 DNAJC22 ZFPM2 BNC1	1.20e-04	184	116	5	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA4 ZFPM2 ADAMTS6 NID1 UNC80	1.23e-04	185	116	5	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MXRA5 CMYA5 PPL BNC1 PTPN13	1.23e-04	185	116	5	e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2E1 LAMA4 PPL DCHS1 TWSG1	1.27e-04	186	116	5	b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX LYST CEP350 MACF1 UTRN	1.27e-04	186	116	5	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2E1 LAMA4 PPL DCHS1 TWSG1	1.27e-04	186	116	5	cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAOA LYST ZFPM2 LRP8 ADAMTS6	1.27e-04	186	116	5	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA4 ZFPM2 MACF1 NID1 UTRN	1.27e-04	186	116	5	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	LAMA4 SLC16A12 ZFPM2 MACF1 NID1	1.30e-04	187	116	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP2E1 LAMA4 PPL DCHS1 TWSG1	1.30e-04	187	116	5	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP2E1 LAMA4 PPL DCHS1 TWSG1	1.30e-04	187	116	5	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	LGR4 ABCA10 CLMN PKHD1 ARHGEF3	1.33e-04	188	116	5	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	ZFPM2 FAT1 CADPS PCDH18 UNC80	1.36e-04	189	116	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	LAMA4 LGR4 MACF1 NID1 PCDH18	1.36e-04	189	116	5	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMTF1 MACF1 ARHGEF3 MAPRE2 UTRN	1.40e-04	190	116	5	d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2E1 LAMA4 ZFPM2 TWSG1 NR1D2	1.40e-04	190	116	5	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2E1 LAMA4 ZFPM2 TWSG1 NR1D2	1.40e-04	190	116	5	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ETV6 CMYA5 PTPN13 PKHD1 TWSG1	1.43e-04	191	116	5	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 ZDBF2 UBN2 TWSG1 UNC80	1.43e-04	191	116	5	fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 CNTRL CCDC50 YY1 CEP350	1.43e-04	191	116	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	facs-Pancreas-Endocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 ZDBF2 OCRL TWSG1 UNC80	1.43e-04	191	116	5	b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA4 ABCA10 ZFPM2 NID1 PCDH18	1.43e-04	191	116	5	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	COVID-19-kidney-Mito-rich_Distal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGEF28 LGR4 SLC16A12 CLMN PKHD1	1.43e-04	191	116	5	0965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 ZDBF2 OCRL TWSG1 UNC80	1.43e-04	191	116	5	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 CNTRL CCDC50 YY1 CEP350	1.43e-04	191	116	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA4 ABCA10 ZFPM2 NID1 PCDH18	1.43e-04	191	116	5	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA4 ABCA10 ZFPM2 NID1 PCDH18	1.47e-04	192	116	5	bc84b9ce01b4d826a682842ab8a395dac9b91183
Drug	prazosin hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	VIM MAOA LAMA4 IRF6 YY1 NF1 PEX16 MAPRE2 ZNF639	6.71e-07	197	114	9	826_UP
Drug	Sulfanilamide [63-74-1]; Up 200; 23.2uM; HL60; HT_HG-U133A	SERHL2 MXRA5 SPACA9 RIF1 PTPN13 NF1 FOXG1 ZNF639	7.38e-06	199	114	8	2709_UP
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	NRIP1 SETX PUM2 CEP350 RIF1 BANP PUM1	3.72e-05	182	114	7	3887_DN
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	NRIP1 SETX PUM2 CEP350 RIF1 BANP PUM1	3.99e-05	184	114	7	2321_DN
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	NRIP1 SETX PUM2 CEP350 MDN1 BANP PUM1	4.13e-05	185	114	7	1114_DN
Drug	C768-0445; Up 200; 10uM; MCF7; HT_HG-U133A_EA	SERHL2 VIM CNTRL ZBTB43 LAMA4 LYST NF1	4.57e-05	188	114	7	865_UP
Drug	Gliquidone [33342-05-1]; Up 200; 7.6uM; PC3; HT_HG-U133A	MAOA LAMA4 SPACA9 HUWE1 YY1 SPTBN5 FOXG1	4.89e-05	190	114	7	7301_UP
Drug	Hymecromone [90-33-5]; Down 200; 22.8uM; PC3; HT_HG-U133A	MAOA LAMA4 OCRL YY1 NEK1 BRCA1 BUB1	5.40e-05	193	114	7	4623_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Up 200; 13uM; PC3; HT_HG-U133A	CYP2E1 ETV6 HUWE1 SPTBN5 PRDM10 ZNF639 PSD4	5.58e-05	194	114	7	4537_UP
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A	VIM YY1 CEP350 NF1 PEX16 MACF1 PSD4	5.58e-05	194	114	7	5457_DN
Drug	aspirin, USP; Down 200; 100uM; PC3; HT_HG-U133A	SERHL2 CNTRL YY1 NF1 BUB1 MAPRE2 ZNF639	5.77e-05	195	114	7	4428_DN
Drug	plakin	VIM PPL SPTBN5 MACF1 UTRN	5.78e-05	82	114	5	CID000018752
Drug	Apramycin [37321-09-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A	SERHL2 CNTRL LAMA4 SPACA9 RIF1 NF1 ZNF639	6.15e-05	197	114	7	7334_UP
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Down 200; 5.8uM; HL60; HT_HG-U133A	MDM1 ZBTB43 OCRL LYST SF3B3 BUB1 UTRN	6.15e-05	197	114	7	2543_DN
Drug	Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; PC3; HT_HG-U133A	SERHL2 LAMA4 NEK1 PTPN13 BUB1 NID1 MAPRE2	6.15e-05	197	114	7	4613_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	VIM ARHGEF28 LYST SPTBN5 NF1 ZNF639 PSD4	6.35e-05	198	114	7	3575_UP
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; PC3; HT_HG-U133A	SERHL2 MAOA CYP2E1 YY1 NEK1 UTRN FOXG1	6.35e-05	198	114	7	4621_DN
Drug	Moricizine hydrochloride [31883-05-3]; Down 200; 8.6uM; MCF7; HT_HG-U133A	YY1 LYST NEK1 RIF1 NF1 BRCA1 ZNF335	6.35e-05	198	114	7	3520_DN
Drug	Harmane hydrochloride [21655-84-5]; Up 200; 18.2uM; PC3; HT_HG-U133A	CNTRL LAMA4 NEK1 RIF1 NF1 UTRN PSD4	6.35e-05	198	114	7	4584_UP
Drug	Ethaverine hydrochloride [985-13-7]; Up 200; 9.2uM; MCF7; HT_HG-U133A	SERHL2 ZBTB43 IRF6 LYST NEK1 NF1 CLMN	6.55e-05	199	114	7	5337_UP
Drug	Fusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A	ZNF131 SETX MDM1 IRF6 OCRL NEK1 ZNF639	6.55e-05	199	114	7	5353_DN
Drug	Nifurtimox [23256-30-6]; Up 200; 14uM; PC3; HT_HG-U133A	SERHL2 CYP2E1 MDM1 HUWE1 CLMN FOXG1 PSD4	6.55e-05	199	114	7	6608_UP
Disease	colorectal cancer (is_implicated_in)	CYP2E1 FAT1 PTPN13 BRCA1 BUB1 MLH1	5.41e-06	121	107	6	DOID:9256 (is_implicated_in)
Disease	Colorectal Carcinoma	RELCH ABCA10 KMT2C TNNI3K FAT1 NF1 BUB1 PKHD1 DCHS1 MLH1 NID1 SDF4	9.45e-06	702	107	12	C0009402
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C FAT1 BRCA1 MLH1	2.17e-05	45	107	4	DOID:3748 (is_implicated_in)
Disease	Intellectual Disability	DOCK8 YY1 KMT2C NF1 BRCA1 ZNF335 MACF1 PUM1 FOXG1	3.75e-05	447	107	9	C3714756
Disease	Fibrosarcoma	ETV6 NF1	3.90e-05	3	107	2	C0016057
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY4 LYST	7.78e-05	4	107	2	DOID:2935 (implicated_via_orthology)
Disease	DnaJ homolog subfamily B member 11 measurement	ZFPM2 ARHGEF3	1.94e-04	6	107	2	EFO_0801537
Disease	mitogen-activated protein kinase 8 measurement	ZFPM2 ARHGEF3	1.94e-04	6	107	2	EFO_0020580
Disease	Adult only	BRCA1 MLH1	1.94e-04	6	107	2	C3842001
Disease	heparan sulfate glucosamine 3-O-sulfotransferase 3A1 measurement	ZFPM2 ARHGEF3	1.94e-04	6	107	2	EFO_0801671
Disease	glutathione peroxidase 7 measurement	ZFPM2 ARHGEF3	1.94e-04	6	107	2	EFO_0801635
Disease	twisted gastrulation protein homolog 1 measurement	TWSG1 ARHGEF3	3.60e-04	8	107	2	EFO_0803205
Disease	hair colour measurement	TRAF1 LGR4 PUM2 UNC13D LYST BNC1 BANP PKHD1 PPP6R3	4.10e-04	615	107	9	EFO_0007822
Disease	Prostatic Neoplasms	VIM TRAF1 CYP2E1 ACRBP UNC13D PPL KMT2C BRCA1 MLH1	4.15e-04	616	107	9	C0033578
Disease	Malignant neoplasm of prostate	VIM TRAF1 CYP2E1 ACRBP UNC13D PPL KMT2C BRCA1 MLH1	4.15e-04	616	107	9	C0376358
Disease	5-formyltetrahydrofolate cyclo-ligase measurement	ZFPM2 ARHGEF3	4.61e-04	9	107	2	EFO_0801335
Disease	Amyotrophic Lateral Sclerosis	SETX ARHGEF28 NEK1	1.24e-03	58	107	3	C0002736
Disease	severe acute respiratory syndrome, COVID-19	MXRA5 ARHGEF28 WDFY4 LYST ZFPM2 CADPS ARHGEF3	1.24e-03	447	107	7	EFO_0000694, MONDO_0100096
Disease	colon cancer (is_marker_for)	NF1 BRCA1 MLH1	1.30e-03	59	107	3	DOID:219 (is_marker_for)
Disease	nasopharynx carcinoma (is_implicated_in)	CYP2E1 BRCA1	1.33e-03	15	107	2	DOID:9261 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	NEK1 PKHD1	1.51e-03	16	107	2	DOID:0110861 (implicated_via_orthology)
Disease	Pheochromocytoma, Extra-Adrenal	MAOA NF1	1.51e-03	16	107	2	C1257877
Disease	Profound Mental Retardation	DOCK8 YY1 NF1 FOXG1	1.67e-03	139	107	4	C0020796
Disease	Mental Retardation, Psychosocial	DOCK8 YY1 NF1 FOXG1	1.67e-03	139	107	4	C0025363
Disease	Mental deficiency	DOCK8 YY1 NF1 FOXG1	1.67e-03	139	107	4	C0917816
Disease	aspartate aminotransferase to alanine aminotransferase ratio	VIM USP16 SF3B3 MLH1 MAPRE2	1.82e-03	239	107	5	EFO_0010934
Disease	obesity	ZDBF2 CMYA5 TNNI3K FAT1 PKHD1	1.89e-03	241	107	5	EFO_0001073
Disease	Brugada syndrome	ZFPM2 MAPRE2	2.14e-03	19	107	2	MONDO_0015263
Disease	Pheochromocytoma	MAOA NF1	2.14e-03	19	107	2	C0031511
Disease	stomach cancer (is_implicated_in)	CYP2E1 KMT2C BRCA1	2.31e-03	72	107	3	DOID:10534 (is_implicated_in)
Disease	airway responsiveness measurement	WDFY4 CAPRIN2	3.41e-03	24	107	2	EFO_0006897
Disease	stomach carcinoma (is_marker_for)	KMT2C BRCA1	3.41e-03	24	107	2	DOID:5517 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENLVSFLETVNQPHH	TWSG1	131	Q9GZX9
VQITQDSEGNLQIHH	BANP	406	Q8N9N5
PEHHNLENEVSRLED	CNTRL	1316	Q7Z7A1
HTPNDNPDQQHLEEA	ARHGEF3	276	Q9NR81
ADENQNHHLEPEEVL	SDF4	326	Q9BRK5
HQVVETSHEDLPASQ	BUB1	301	O43683
HSLQEQEIEHHLASN	CCDC50	31	Q8IVM0
EDNDEVHIEVHNPRN	CPSF3	436	Q9UKF6
HQNTHHEIFENEINP	ABCA10	356	Q8WWZ4
VEHRQEPTQEHKQEE	ACRBP	201	Q8NEB7
EHQVHPNASDQEDEA	GVINP1	926	Q7Z2Y8
SPQSHRVSEEQHVQS	BNC1	581	Q01954
PILQHHQEESNIIGS	DMTF1	726	Q9Y222
TEDQPNLEINHHADK	ADAMTS6	306	Q9UKP5
QQAIPASHNIIHNEE	RAD51AP2	791	Q09MP3
AHIQVTVVDVNDHTP	PCDHGA7	226	Q9Y5G6
VSERVKEHHQSLDPN	CYP2E1	246	P05181
QTLPILEELHQHTEQ	PUM2	901	Q8TB72
VEASEESALNHVQHP	MRFAP1L1	71	Q96HT8
TQPQQQHPHQSLEDD	PCDH18	956	Q9HCL0
IQNADTDQEPVSHLH	PM20D1	486	Q6GTS8
LVVQHNEHEDQHSLD	ARHGEF28	326	Q8N1W1
DQVKLNHPVTHVDQS	MAOA	236	P21397
NHPVTHVDQSSDNII	MAOA	241	P21397
LEDPQYQDQHSLHTE	RELCH	1051	Q9P260
EVLQQNEEHHAEPHV	CADPS	891	Q9ULU8
HTQPEVILHQNHEED	ETV6	141	P41212
HFEEVTIPPLDSQQH	FAT1	4571	Q14517
ATVHVQLQDQNDHAP	DCHS1	2466	Q96JQ0
FHGPEHVVEQVQELD	KIAA0100	981	Q14667
HPEEHSEEQQQSVEE	MDN1	4971	Q9NU22
QVHTEEQQKSHPSES	KMT2C	581	Q8NEZ4
VHSEHLNLVPQVQSV	NEK1	991	Q96PY6
SQHTPVEEQAQHSDL	INTS1	1071	Q8N201
QEVHVQSLPQVDRHT	MMS19	136	Q96T76
DPEDVNILHSEITNH	LIPJ	316	Q5W064
QELESSQRQIEEQHH	PPFIA4	461	O75335
ENISQNPQHEDDHKS	ZFPM2	1061	Q8WW38
NSLVPEAVQNDNHHA	FOXG1	21	P55316
TDLPLVDHQVEEHNI	PPL	156	O60437
HENHLNQDDTVPESS	PPL	631	O60437
HQQHPQVIDVDEVEE	NID1	361	P14543
DDAQQKIEPHHTAVL	PIR	206	O00625
TNHTPVNENVELEHS	MDM1	141	Q8TC05
DDLQIPNTNVHLSHD	NRIP1	761	P48552
ENEEHSQIIIHCTPS	LGR4	511	Q9BXB1
AEAKEQLTDHHPQTN	GOLGA6L1	61	Q8N7Z2
HFDPVIQLQEEAHLN	MOB1B	166	Q7L9L4
EHEQNAAQVHFVPDT	PRDM10	16	Q9NQV6
HDQHAVLVLQPAVEA	HUWE1	3871	Q7Z6Z7
ELQLETQQHIHTSVE	MACF1	616	Q9UPN3
QTLPILEELHQHTEQ	PUM1	1021	Q14671
QKTLHPSEEEVNQLH	MOGAT2	291	Q3SYC2
TEHHQPSNNDLNTTE	BRCA1	236	P38398
VAQTQDHHQELETRN	CLDN22	201	Q8N7P3
VPVEFQEHHLSEVQN	IDH3B	76	O43837
HPVFEHLDSTQNTEN	BCLAF3	451	A2AJT9
DPHLHLNIEESNQEF	C6orf52	106	Q5T4I8
VQAVSSVHTQDNHLE	DOCK8	726	Q8NF50
HSHLEPLESQEQDRI	ETV7	316	Q9Y603
HRNQVPLLHEVNSED	CEP89	161	Q96ST8
HDEIENHSLSQEGNL	CMYA5	2731	Q8N3K9
LEEPSHQHVTQETQA	CEP350	671	Q5VT06
VLEAHVHQQSSVDSQ	CEP350	2646	Q5VT06
QLPSIHVEQTVHSQE	CAPRIN2	806	Q6IMN6
FQTEISEENIHHEQS	LYST	2681	Q99698
SEENIHHEQSSVFNP	LYST	2686	Q99698
HTEEPEAEEQAHEQQ	MAPRE2	306	Q15555
PDHNLDQTEEAQRHF	DNAJC22	306	Q8N4W6
HVLQVEASQEPSHVF	SERHL2	156	Q9H4I8
KVLQHVSEPQAHQES	SPACA9	161	Q96E40
VVENHLAIEQPNTHL	KCNE1B	111	A0A087WTH5
QAHAVSHPNEIETVE	MAP3K19	116	Q56UN5
PAEEDHHNEERQTKN	CPHXL	11	A0A1W2PPM1
AENLNNPHDIVIFHE	LRP8	666	Q14114
SHHAAIEILQNAPED	PTPN13	1156	Q12923
DTINHASQLVEQAHD	LAMA4	376	Q16363
EEDELDQSQHHVPIQ	IRF6	146	O14896
HLQNDTLVEHHEQTA	NR1D2	206	Q14995
TLVEHHEQTALPAQE	NR1D2	211	Q14995
EGRQQQHHEELSATP	PEX16	196	Q9Y5Y5
HVLQVEASQEPSHVF	SERHL	156	Q9NQF3
IHQQELEVGISSHQP	UTRN	2016	P46939
NDIQPHSVVEDVHPS	RNF133	361	Q8WVZ7
EDHTTPEQNHVCRTQ	SLC16A12	231	Q6ZSM3
QEDHHTSQKVEEPSQ	RIF1	2111	Q5UIP0
DVQPDIHLTSAEHEN	PSD4	531	Q8NDX1
VNHEANSVAVDVIPH	RNF128	391	Q8TEB7
LEREHPEQHVSTVNS	SETX	1041	Q7Z333
VEVHVQDALAPVHTQ	PKHD1	1141	P08F94
QNVDVNVHPTKHEVH	MLH1	301	P40692
HEKEQHVQDIIPINS	OCRL	46	Q01968
HPQAQHIVEQCQELE	SPTBN5	1591	Q9NRC6
HENPCIEQQLDDVHQ	ANKRD20A12P	31	Q8NF67
LAPHEDHQQRETKEN	CLMN	816	Q96JQ2
EHQVTESINTVQTEH	ZBTB43	266	O43298
HTDPHVQQIAVAILD	ZYG11B	706	Q9C0D3
SNLEIHQKIHTEENP	ZNF761	591	Q86XN6
HTEDPFNDEHQERQE	UBN2	161	Q6ZU65
TNDPEDLHSHVVNEH	ZNF639	326	Q9UID6
AQPAENHEELSARQH	UNC80	2861	Q8N2C7
HAQLIQSDDDIGDHQ	TMEM9B	136	Q9NQ34
HPDEINIEILNDSHT	USP16	586	Q9Y5T5
HHPQDEVQVTVNLDQ	TMEM143	181	Q96AN5
LVDVSNPTEQEHLQH	STEAP3	111	Q658P3
NPTEQEHLQHRESNA	STEAP3	116	Q658P3
TDDPTQVHHHQEVIL	YY1	91	P25490
HEDHPQLSEEIQCSL	WDFY4	846	Q6ZS81
DGQVINETSQHHDDL	VIM	451	P08670
HSAHDEPQEALDEVN	ZDBF2	716	Q9HCK1
AEHIEHEQQKLPAAT	NF1	1716	P21359
PQSVQEHEVTSQTSH	TRAF1	101	Q13077
HPESNNLIIIETDHN	SF3B3	791	Q15393
IEQIHPSKDENQHSN	PPP6R1	196	Q9UPN7
VSVSQNQHRDVVPEH	YME1L1	36	Q96TA2
SNLEIHQKIHTEENP	ZNF765	451	Q7L2R6
EQVHPDLLQDSQVHD	ZNF131	496	P52739
EEERQNSHHSQPERQ	RPTN	126	Q6XPR3
ADVNAQDNEDHVPLH	TNNI3K	226	Q59H18
TDETVPEHIQQLQHQ	ZNF335	1316	Q9H4Z2
VEIVHPSQEEDRHSN	PPP6R3	196	Q5H9R7
QEAFHVEPEEHQQTL	UNC13D	86	Q70J99
ESHQHGEVLTQVPDD	ZNF878	76	C9JN71
EHNHNGVILVEPEVT	MXRA5	866	Q9NR99