Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	zf-RNPHF	HNRNPF HNRNPH1 HNRNPH2	1.49e-08	3	47	3	PF08080
Domain	Znf_CHHC	HNRNPF HNRNPH1 HNRNPH2	1.49e-08	3	47	3	IPR012996
Domain	ZINC_FINGER_C2H2_2	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	6.34e-04	775	47	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	6.45e-04	777	47	8	PS00028
Domain	Znf_C2H2-like	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	7.55e-04	796	47	8	IPR015880
Domain	Znf_C2H2	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	8.13e-04	805	47	8	IPR007087
Domain	ZnF_C2H2	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	8.33e-04	808	47	8	SM00355
Domain	-	ZNF276 ZNF555 ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	1.44e-03	679	47	7	3.30.160.60
Domain	zf-C2H2	ZNF276 ZNF555 ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	1.62e-03	693	47	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF276 ZNF555 ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	1.64e-03	694	47	7	IPR013087
Domain	KRAB	ZNF555 ZNF564 ZNF433 ZNF441 ZNF563	1.99e-03	358	47	5	PS50805
Domain	KRAB	ZNF555 ZNF564 ZNF433 ZNF441 ZNF563	1.99e-03	358	47	5	PF01352
Domain	KRAB	ZNF555 ZNF564 ZNF433 ZNF441 ZNF563	2.27e-03	369	47	5	SM00349
Domain	KRAB	ZNF555 ZNF564 ZNF433 ZNF441 ZNF563	2.30e-03	370	47	5	IPR001909
Domain	WD40	WDR7 WDR88 STRN4 CFAP43	4.56e-03	268	47	4	SM00320
Domain	WD40_repeat	WDR7 WDR88 STRN4 CFAP43	4.80e-03	272	47	4	IPR001680
Domain	WD_REPEATS_1	WDR7 WDR88 STRN4 CFAP43	5.18e-03	278	47	4	PS00678
Domain	WD_REPEATS_2	WDR7 WDR88 STRN4 CFAP43	5.25e-03	279	47	4	PS50082
Domain	WD_REPEATS_REGION	WDR7 WDR88 STRN4 CFAP43	5.25e-03	279	47	4	PS50294
Domain	SET	KMT2D PRDM15	5.98e-03	46	47	2	SM00317
Domain	WD40_repeat_dom	WDR7 WDR88 STRN4 CFAP43	6.53e-03	297	47	4	IPR017986
Domain	SET_dom	KMT2D PRDM15	7.03e-03	50	47	2	IPR001214
Domain	SET	KMT2D PRDM15	7.03e-03	50	47	2	PS50280
Domain	Quinoprotein_ADH-like_supfam	WDR7 WDR88	7.87e-03	53	47	2	IPR011047
Domain	WD40_repeat_CS	WDR7 WDR88 STRN4	8.12e-03	164	47	3	IPR019775
Domain	-	WDR7 WDR88 STRN4 CFAP43	9.69e-03	333	47	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR7 WDR88 STRN4 CFAP43	9.89e-03	335	47	4	IPR015943
Pubmed	hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization.	HNRNPF HNRNPH1 HNRNPH2	2.80e-09	3	50	3	10456323
Pubmed	Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues.	HNRNPF HNRNPH1 HNRNPH2	2.80e-09	3	50	3	14980514
Pubmed	Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.	HNRNPF HNRNPH1 HNRNPH2	2.80e-09	3	50	3	7499401
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF555 ZNF564 HNRNPF HNRNPH1 ZNF441 ZNF563	2.40e-07	181	50	6	37372979
Pubmed	Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.	HNRNPF HNRNPH1 HNRNPH2	4.58e-07	11	50	3	21900255
Pubmed	A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.	HNRNPF HNRNPH1 HNRNPH2	6.09e-07	12	50	3	37463454
Pubmed	Tandem immunoprecipitation approach to identify HIV-1 Gag associated host factors.	HNRNPF HNRNPH1 HNRNPH2	1.55e-06	16	50	3	24690621
Pubmed	The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization.	HNRNPF HNRNPH1	2.03e-06	2	50	2	7512260
Pubmed	The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells.	HNRNPF HNRNPH2	2.03e-06	2	50	2	37399401
Pubmed	The small RNA mascRNA differentially regulates TLR-induced proinflammatory and antiviral responses.	HNRNPF HNRNPH1	2.03e-06	2	50	2	34582376
Pubmed	Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.	HNRNPF HNRNPH1	2.03e-06	2	50	2	23284676
Pubmed	Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F.	HNRNPF HNRNPH1	2.03e-06	2	50	2	21739230
Pubmed	BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.	DUSP9 SMAD4	2.03e-06	2	50	2	22305567
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	HNRNPF HNRNPH1 HNRNPH2	4.22e-06	22	50	3	18377426
Pubmed	A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.	HNRNPF HNRNPH1	6.07e-06	3	50	2	20308327
Pubmed	Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.	HNRNPF HNRNPH1	6.07e-06	3	50	2	19244236
Pubmed	hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells.	HNRNPF HNRNPH1	6.07e-06	3	50	2	9858532
Pubmed	Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.	HNRNPH1 HNRNPH2	6.07e-06	3	50	2	21068389
Pubmed	Interaction between the human nuclear cap-binding protein complex and hnRNP F.	HNRNPF HNRNPH1	1.21e-05	4	50	2	9111328
Pubmed	Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells.	HNRNPF HNRNPH1	1.21e-05	4	50	2	30468106
Pubmed	An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.	HNRNPF HNRNPH1	1.21e-05	4	50	2	23255806
Pubmed	A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction.	HNRNPF HNRNPH1	1.21e-05	4	50	2	25169827
Pubmed	A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.	HNRNPF HNRNPH1 HNRNPH2	2.28e-05	38	50	3	18247557
Pubmed	Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1.	HNRNPF HNRNPH2	3.03e-05	6	50	2	11054566
Pubmed	Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.	HNRNPF HNRNPH1	4.23e-05	7	50	2	11003644
Pubmed	A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.	HNRNPH1 HNRNPH2	4.23e-05	7	50	2	31704785
Pubmed	Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.	HNRNPH1 HNRNPH2	4.23e-05	7	50	2	25846207
Pubmed	Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.	HNRNPF HNRNPH1 HNRNPH2	4.92e-05	49	50	3	27352031
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	KMT2D MRPL12 HNRNPF HNRNPH1	1.06e-04	170	50	4	16159877
Pubmed	FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).	HNRNPF HNRNPH1	2.10e-04	15	50	2	27365398
Pubmed	A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.	HNRNPF HNRNPH1	2.72e-04	17	50	2	12388589
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	USP34 KMT2D HNRNPF HNRNPH2	2.86e-04	220	50	4	35785414
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	HNRNPF HNRNPH1 HNRNPH2	2.91e-04	89	50	3	22446626
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	MRPL12 SEC24B SCAPER STRN4 HNRNPF HNRNPH1 HNRNPH2	3.33e-04	922	50	7	27609421
Pubmed	hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.	HNRNPF HNRNPH1	3.41e-04	19	50	2	35739118
Pubmed	An unappreciated role for RNA surveillance.	ZAN CLK2 ADAM22	4.34e-04	102	50	3	14759258
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KLHL1 CEP72 SCAPER	4.47e-04	103	50	3	10819331
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	SCAPER STRN4 ADPRHL1 PRDM15 HNRNPH1 SMAD4	4.48e-04	689	50	6	36543142
Pubmed	The protein interaction landscape of the human CMGC kinase group.	AMMECR1L CLK2 DUSP9 HNRNPF HNRNPH2 SMAD4	4.69e-04	695	50	6	23602568
Pubmed	The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.	HNRNPF HNRNPH1	5.03e-04	23	50	2	22912744
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	HNRNPF HNRNPH1 HNRNPH2	5.27e-04	109	50	3	12226669
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	HNRNPF HNRNPH1 HNRNPH2	5.27e-04	109	50	3	29511296
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	HNRNPF HNRNPH1 HNRNPH2	6.32e-04	116	50	3	30652415
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CEP72 SEC24B HNRNPF HNRNPH1 HNRNPH2	7.09e-04	494	50	5	26831064
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	HNRNPF HNRNPH2	7.48e-04	28	50	2	20975687
Pubmed	Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).	HNRNPF HNRNPH1	7.48e-04	28	50	2	22178446
Pubmed	Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.	HNRNPF HNRNPH1	7.48e-04	28	50	2	38492217
Pubmed	Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells.	HNRNPF HNRNPH1	9.77e-04	32	50	2	21853274
Pubmed	DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.	HNRNPF HNRNPH1	1.10e-03	34	50	2	32152128
Pubmed	A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.	HNRNPF HNRNPH1	1.17e-03	35	50	2	29104064
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	HNRNPF HNRNPH1 HNRNPH2	1.25e-03	147	50	3	28977470
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	HNRNPF HNRNPH1 HNRNPH2	1.28e-03	148	50	3	35676246
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	MYT1 HNRNPF	1.38e-03	38	50	2	28218735
Cytoband	19p13.2	ZNF564 ZNF433 ZNF441 ZNF563	1.16e-04	229	50	4	19p13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF276 ZNF555 SCAPER ZNF564 PRDM15 ZNF433 ZNF441 ZNF563	5.40e-05	718	35	8	28
GeneFamily	WD repeat domain containing	WDR7 WDR88 STRN4 CFAP43	1.58e-03	262	35	4	362
GeneFamily	RNA binding motif containing	HNRNPF HNRNPH1 HNRNPH2	8.00e-03	213	35	3	725
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	YDJC CCDC116	1.75e-03	38	48	2	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	myositis	YDJC CCDC116	1.85e-03	39	48	2	EFO_0000783
Disease	osteoarthritis, hip, osteoarthritis, knee	BTNL8 THSD7B	4.60e-03	62	48	2	EFO_0004616, EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
MISAHCSNLHFLGSS	nan	1	Q8N976
MSCSHTRTALLSGGQ	ABCG4	191	Q9H172
CRSHSHQGHGIQSMR	CFAP43	676	Q8NDM7
RGCIGTFSAMNLHSG	AMMECR1L	151	Q6DCA0
HSSLMAGCLGSHSRD	CCDC116	161	Q8IYX3
AGSISCSMRHAHLSR	BTNL8	201	Q6UX41
HGHMCISFELLGLST	CLK2	236	P49760
TGMTLSGNNTICFHH	ARL14EP	46	Q8N8R7
TFSHHRACLLRSPGM	ALDH3B1	421	P43353
DSFVALSTCHGLHGM	ADAM22	146	Q9P0K1
NCSHSRNDMCHSLGL	CD5	116	P06127
MALFPHSSASHGGCQ	CEP72	631	Q9P209
HCMLGHTIDLNSGSK	RAB9B	181	Q9NP90
AFHGRTMGCLATTHS	ABAT	216	P80404
SSFQSTTGHCVHMRG	HNRNPH2	281	P55795
HLCETSLAGRAGSSM	DUSP9	136	Q99956
SGLSLHHGMASSLLS	MEIKIN	116	A0A087WXM9
STFQSTTGHCVHMRG	HNRNPH1	281	P31943
GRMLHACTSEGSAHR	HGFAC	116	Q04756
RMTHNHPTGFLGSLC	ADPRHL1	161	Q8NDY3
SCLTMHVGSRGFGSN	KRTAP13-3	91	Q3SY46
ATRMTGQVHGSGCHL	LINC00526	31	Q96FQ7
IRCTKGLSMHTFHGN	SEC24B	926	O95487
AFRHMASSLLGHCSQ	SCAPER	1246	Q9BY12
MLLGSCSISHLHSLF	OR1L6	181	Q8NGR2
FTVQSTTGHCVHMRG	HNRNPF	281	P52597
SACMNSRTNGTIHFG	SAMD9L	226	Q8IVG5
FSCRSNMNKHLLTHG	PRDM15	911	P57071
HSLMCHRQGGESETF	SMAD4	21	Q13485
HLIQSCGLGGMRHNS	SLC12A4	776	Q9UP95
HMRSSGHQRCEALAG	MRPL12	36	P52815
HRGREAQMSHSSHCG	LINC00612	151	Q8N6U2
AQMSHSSHCGSRSCS	LINC00612	156	Q8N6U2
VSLSCGHFHRTMNIL	ATP11B	716	Q9Y2G3
SLCGKVFMHHSSLSR	ZNF564	106	Q8TBZ8
SDCTGFRRHMITHTG	ZNF441	346	Q8N8Z8
LSSFRRHMITHTGNG	ZNF441	571	Q8N8Z8
CGKAFSHPSSFRGHM	ZNF555	401	Q8NEP9
LMQGHEGSVSSCHFA	WDR88	316	Q6ZMY6
SRTNGSLCHATAMCH	TTC6	206	Q86TZ1
MGHCRLCHGKFSSRS	ZNF276	76	Q8N554
FVGLSTCGRHMSAHR	YDJC	206	A8MPS7
TCGRHMSAHRVSGAL	YDJC	211	A8MPS7
CGKALSHSSSFRRHM	ZNF563	426	Q8TA94
GAFLMSGSHDCSLRL	STRN4	691	Q9NRL3
SLSCGHSRGLFSHMQ	USP34	3501	Q70CQ2
RSLSCMVHSGSISHA	THSD7B	1326	Q9C0I4
CTVSFGLLSRGGHMS	WDR7	831	Q9Y4E6
FGSASHLQMHGRTHT	ZNF433	571	Q8N7K0
CASRLQMHGRTHTGE	ZNF433	601	Q8N7K0
LALMLCHALFTTGSH	TMEM239	116	Q8WW34
LTFDGALHHFMGTCT	ZAN	1551	Q9Y493
LASRGGHMTQSGQCH	nan	91	Q8N9L7
GHMTQSGQCHVSGSL	nan	96	Q8N9L7
EGCGHRLSSTGHSMT	KLHL1	161	Q9NR64
AGLSHLQQSLMSHSG	KMT2D	3871	O14686
HANGSFLTHRSLSGC	MYT1	956	Q01538