Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoembryonic lethality between implantation and somite formation

SMARCC1 SIN3A DSP RPTOR HGS

5.46e-05340185MP:0006205
DomainKRAB

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

1.95e-08358268PF01352
DomainKRAB

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

2.46e-08369268SM00349
DomainKRAB

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

2.52e-08370268IPR001909
Domainzf-C2H2_6

ZNF69 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

1.78e-07314267PF13912
DomainKRAB

ZNF69 ZNF233 ZNF799 ZNF700 ZNF763 ZNF439 ZNF443

4.31e-07358267PS50805
Domain-

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

2.56e-066792683.30.160.60
Domainzf-C2H2

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

2.98e-06693268PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

3.01e-06694268IPR013087
DomainZINC_FINGER_C2H2_2

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

6.81e-06775268PS50157
DomainZINC_FINGER_C2H2_1

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

6.94e-06777268PS00028
DomainZnf_C2H2-like

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

8.28e-06796268IPR015880
DomainZnf_C2H2

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

8.99e-06805268IPR007087
DomainZnF_C2H2

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

9.24e-06808268SM00355
DomainZnf_FYVE_PHD

TCF20 HGS

1.77e-02147262IPR011011
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

SMARCC1 ZNF233 ZNF799 SIN3A ELOA2 ZNF700 ZNF439 ZNF443 RPTOR

1.28e-041387229M734
Pubmed

Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.

SIN3A CBFA2T2

5.37e-06526216227606
Pubmed

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

SMARCC1 SIN3A

8.05e-06626215314177
Pubmed

The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.

SIN3A CBFA2T2

1.13e-05726212242670
Pubmed

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression.

SMARCC1 SIN3A

1.13e-05726217074803
Pubmed

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.

SIN3A SMC2

1.50e-05826215148359
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SMARCC1 SIN3A TCF20 DSP RPTOR CBFA2T2

1.88e-0577426615302935
Pubmed

Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.

SMARCC1 SIN3A

2.41e-051026211238380
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SMARCC1 SIN3A TCF20 SMC2 DSP

4.81e-0554926538280479
Pubmed

E protein silencing by the leukemogenic AML1-ETO fusion protein.

SIN3A CBFA2T2

4.86e-051426215333839
Pubmed

Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.

SMARCC1 SIN3A

5.61e-051526217255939
Pubmed

A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.

SMARCC1 SIN3A

6.41e-051626211013263
Pubmed

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

SMARCC1 SIN3A

6.41e-051626211784859
Pubmed

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.

SMARCC1 SIN3A

8.16e-051826214559996
Pubmed

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

SMARCC1 SIN3A

1.12e-042126212453419
Pubmed

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.

DSP RPTOR

1.35e-042326219841136
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SMARCC1 SIN3A TCF20 HLA-C DSP RPTOR

2.15e-04120326629180619
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

ESCO2 SMARCC1 SIN3A

2.17e-0415726330186101
Pubmed

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

SIN3A CBFA2T2

2.31e-043026226593974
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ESCO2 SMARCC1 SIN3A SMC2

2.34e-0441126435182466
Pubmed

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

SMARCC1 SIN3A

3.15e-043526222325351
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

TCF20 HLA-C FAM111B

3.25e-0418026335198878
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

SMARCC1 SIN3A TCF20 HLA-C

3.38e-0445326429656893
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

SMARCC1 SIN3A SMC2 DSP CBFA2T2

3.84e-0485726525609649
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

ESCO2 TCF20 SMC2 HGS

3.95e-0447226438943005
Pubmed

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

SMARCC1 SIN3A

4.54e-044226216387653
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

SMARCC1 SIN3A TCF20

5.83e-0422026335785414
Pubmed

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

ESCO2 IL12RB2 SMC2

6.39e-0422726326410627
Pubmed

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

SMARCC1 SIN3A

6.70e-045126222770845
Pubmed

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

SMARCC1 SIN3A

7.23e-045326221532573
Cytoband19p13.2

ZNF69 ZNF799 ZNF700 ZNF763 ZNF439 ZNF443

3.06e-0922926619p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ZNF69 ZNF799 ZNF700 ZNF763 ZNF439 ZNF443

4.60e-06797266chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr10q24

ARL3 CALHM3

5.13e-03189262chr10q24
CytobandEnsembl 112 genes in cytogenetic band chr17q25

RPTOR HGS

1.30e-02307262chr17q25
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF69 ZNF233 ZNF799 PRDM9 ZNF700 ZNF763 ZNF439 ZNF443

4.90e-0771820828
ToppCellBac-SEP-Lymphocyte-T_NK-T_NK_proliferative|Bac-SEP / Disease, Lineage and Cell Type

ESCO2 IL12RB2 SMC2 FAM111B

3.77e-06184264848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMARCC1 CALHM3 DSP B3GNT2

4.56e-061932645879efb38e6b3bf8c33c9a773632b1d726e3c153
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMARCC1 CALHM3 DSP B3GNT2

4.56e-06193264725115a5ce3ef520b3ef469e96b8219b4c723fdd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMARCC1 CALHM3 DSP B3GNT2

4.56e-06193264abd7bcf318a2d895d8811c2ada8bfb4314fca3b1
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 IL12RB2 SMC2 FAM111B

4.84e-0619626476f581e35967f8f7c85a8556129f6e8042ad11ca
ToppCellcritical-Lymphoid-NKT-proliferating|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ESCO2 SMC2 DSP FAM111B

5.14e-061992649284956d852e434a91be892e88e06a7c71f8c583
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-T/NK_proliferative|Bac-SEP / Disease, condition lineage and cell class

ESCO2 IL12RB2 SMC2 FAM111B

5.25e-06200264a09b4e07b273880e94032b939ab191caaf6d656e
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRRIQ1 HGS FAM111B

8.07e-05145263186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 SMC2 FAM111B

1.04e-04158263d72d6527dc50207ddbada262460d3c4bac249a19
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 IL12RB2 SMC2

1.16e-04164263ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 ZNF443 FAM111B

1.18e-04165263a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 IL12RB2 SIN3A

1.20e-0416626321ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCellDividing_Macrophages-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.20e-04166263ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCellDividing_Macrophages-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.27e-04169263eb0c993ef2eea73bc4881182520922ce9ae9368f
ToppCellDividing_Macrophages-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.27e-04169263bc859a103cad567caf50c3c3882d2d2017807c73
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.32e-0417126352fdc2a4ec36fb91583b1215362548ceb6740ae1
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.32e-04171263e3cab55f39879e2bd3e8bda91802181075839bc4
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.34e-041722636fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK|bone_marrow / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.36e-041732638a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell10x5'-Lung-Lymphocytic_NK-Cycling_NK|Lung / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.36e-04173263d815832f89f70662706620e3b03ebb1dabec0034
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 SMC2 FAM111B

1.38e-0417426346cbb462173a684ceb9e680f9259dc3b133763f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 ELOA2 SMC2

1.41e-04175263876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.41e-041752636b4e841bde6cfa4956e1a0231672cea20f11210c
ToppCelldroplet-Lung-21m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ESCO2 IL12RB2 SIN3A

1.41e-041752636751ee4b312d7f87275f2c35e5878cfc3be3ebe3
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T|Lung / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.43e-04176263a40dfd8c4ba16757ff929b2f03a0628acf334de4
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_1|367C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.46e-04177263ba701d3c90722d8bff70d0fa651899305cdad257
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 SMC2 FAM111B

1.48e-04178263462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 ELOA2 FAM111B

1.53e-04180263401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCellHealthy_Control-Lymphoid-T-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

ESCO2 SMC2 FAM111B

1.56e-04181263ac1ee313910c05b1b3cb497bae14565464919c21
ToppCellIIH-cycling-|IIH / Condition, Cell_class and T cell subcluster

ESCO2 SMC2 FAM111B

1.56e-041812637f4fed9e296bc22cb5a1e6c8e3c4b641e97c3078
ToppCellIIH-cycling|IIH / Condition, Cell_class and T cell subcluster

ESCO2 SMC2 FAM111B

1.56e-04181263ec3e782ce93dcfe1a54fb7284e4e39063614b0e2
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 SMC2 FAM111B

1.56e-0418126373b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 SMC2 FAM111B

1.58e-04182263e6968e0bd9cef92052d04ac54e2dd746b37623f6
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T|Liver / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.58e-0418226381557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.61e-04183263a48a6313f2f144586951cece97ec31f6d72361df
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.63e-041842636b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.63e-04184263e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCellDividing_Macrophages-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.63e-04184263f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ESCO2 SMC2 FAM111B

1.66e-041852639d424a8608b339dd6129c58d87626678d4ec4af7
ToppCellControl-T_cells-Cycling_NK/T_cells|Control / group, cell type (main and fine annotations)

ESCO2 SMC2 FAM111B

1.66e-041852639766216b41ee62bbac4caa25cb98ec5627a24075
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Tuft-Tuft|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SMARCC1 CALHM3 DSP

1.66e-041852631fbdc96da0623c3935ae9d29dcb4ba9c474e5c21
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Tuft|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SMARCC1 CALHM3 DSP

1.66e-04185263b45487daac116e3d3d65ac2b0f81d1bf7d1a1914
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.66e-041852639d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCellURO-Lymphocyte-T_NK-T_NK_proliferative|URO / Disease, Lineage and Cell Type

ESCO2 SMC2 FAM111B

1.66e-041852630ae9c646679c69a553eda670aef0e0495feb0286
ToppCell3'_v3-blood-Lymphocytic_T_CD4/8-lo|blood / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.66e-04185263df85ff34b796b403f2d0741771e9592e03657f6a
ToppCellDividing_Macrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.69e-041862630067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.69e-04186263189b75aa98903f1cb65b624524ba6c30df7e42ff
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|356C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.69e-04186263261891d0b148e285339ae0b9e36136ceabd9b6f5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 SMC2 FAM111B

1.71e-04187263057569c9437219ecc396aa6e673b1178a2273837
ToppCell10x5'-Liver-Lymphocytic_NK-Cycling_NK|Liver / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.74e-041882635eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-T_NK_proliferative|Multiple_Sclerosis / Disease, Lineage and Cell Type

ESCO2 SMC2 FAM111B

1.74e-041882636c05797a5d0635d89ffcf4aca52178687129ccb4
ToppCell3'_v3-blood-Lymphocytic_T_CD4/8-lo-Cycling_T|blood / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.74e-04188263714ccbcf826f26d39757931a3b8abbd952f4cddc
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.74e-04188263f5102e8d95506c25c675094b86162a6a50087b64
ToppCellnormal-na-Lymphocytic-lymphocyte|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.77e-04189263b83fd81ecc5ef363be7435ee12cb7079e2434af7
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 SMC2 FAM111B

1.77e-04189263fd8834d1feb7f63911c5fa51efb1f679a8baddeb
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ESCO2 SMC2 FAM111B

1.77e-04189263d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellASK454-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

SMARCC1 ELOA2 HGS

1.77e-04189263316c857dec9383823e09f966bca62d52d933b141
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ESCO2 SMC2 FAM111B

1.77e-041892631e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 IL12RB2 FAM111B

1.77e-0418926331d34bc75d4457fca197e1766922e987dbd5f8a9
ToppCellnormal-na-Lymphocytic|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.77e-041892631d382f8eb998c6a30e09fddc9a427afc8f5f7323
ToppCellnormal-na-Lymphocytic-lymphocyte-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.77e-041892633db4177d68cab4cd16842d2ebcaca28f69300e44
ToppCellDividing_Macrophages-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.77e-04189263d4e88a3e50499d683e3db38aee04490146fe30bb
ToppCellInt-URO-Lymphocyte-T_NK-T_NK_proliferative|Int-URO / Disease, Lineage and Cell Type

ESCO2 SMC2 FAM111B

1.79e-04190263005967c540418b85311308072a07c684f4296aef
ToppCell10x5'-lymph-node_spleen-Lymphocytic_NK-Cycling_NK|lymph-node_spleen / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.79e-04190263451eaceb0cb0ec6cfcae00253c0e5c92a168c2f3
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T|GI_small-bowel / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.82e-04191263e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL12RB2 SMC2 FAM111B

1.82e-04191263912e2d10d3423aa7f708fcf2b11da1845f12d7d3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL12RB2 SMC2 FAM111B

1.82e-0419126377a2746b6d9c53b08d4405411c16fcc5a6c734ce
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-Cycling_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ESCO2 IL12RB2 FAM111B

1.82e-041912635d4fed25bd318472a17228b12ade4c331865bda5
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ESCO2 SMC2 FAM111B

1.82e-04191263588015d76b68488da6aa6603777682f3d81592bf
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

ESCO2 SMC2 FAM111B

1.82e-04191263bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.82e-0419126356b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESCO2 SMC2 FAM111B

1.82e-0419126350854384fdaa0efa2e3227659d544ed09ac102f2
ToppCellMild-T/NK_proliferative|World / Disease group and Cell class

ESCO2 SMC2 FAM111B

1.82e-041912639dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCellDividing_Macrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.82e-041912633e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell(3)_Macrophage_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ESCO2 SMC2 FAM111B

1.82e-04191263b42f0b89bb94fd43786ff50f1caeb3ebfbbb43fd
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.82e-04191263210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCellDividing_Macrophages-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 SMC2 FAM111B

1.85e-04192263741bd0c2b0a7ce3fcb1610ce8bdacaf9a803c212
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ESCO2 SMC2 FAM111B

1.85e-04192263f518839ecd9377537a414e8798766f7d91eafeac
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ESCO2 SMC2 FAM111B

1.85e-041922633856c4d611224cd6c2558631147cd5333bc0ccb7
ToppCellcontrol-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ESCO2 SMC2 FAM111B

1.88e-04193263ecb4018a47d9a82bb999e0bc8b3dceabd97d1f0d
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DSP RPTOR CBFA2T2

1.88e-04193263503a979328c68b096680b71359a26f02fafdff35
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ESCO2 SMC2 FAM111B

1.88e-04193263516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ESCO2 SMC2 FAM111B

1.88e-04193263bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-Cycling_T|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ESCO2 SMC2 FAM111B

1.88e-0419326381e6240cffb094b2aa3684fd0889b6497f47c4f0
ToppCellSevere_COVID-19-Myeloid-proliferating_Myeloid_cells|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

ESCO2 SMC2 FAM111B

1.88e-041932630d85025690c9cd545cba30abc38acbdd6a39b153
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ESCO2 SMC2 FAM111B

1.91e-04194263903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCell(1)_T_cells_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ESCO2 SMC2 FAM111B

1.91e-041942638f313071933451780309d2174ed27d8cdc734343
ToppCellwk_15-18-Hematologic_Lymphocytic-B-Pro-B|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ESCO2 SMC2 FAM111B

1.91e-0419426358d7c56d2b9c893b62da2334428d677e3451fe07
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 SMC2 FAM111B

1.91e-04194263f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.91e-04194263635d0e88f9c542a1d9363066c6cdbc6e44db76c1
ToppCell(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ESCO2 SMC2 FAM111B

1.91e-041942634d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ESCO2 SMC2 FAM111B

1.91e-0419426317af04acd54dd6a895a966cbb4422de25dc4f1e6
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|367C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 SMC2 FAM111B

1.91e-04194263a12b64945e10f00aa983678a02586c59badc1570
ToppCellwk_15-18-Hematologic_Lymphocytic-NK-Cycling_NK|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ESCO2 IL12RB2 FAM111B

1.91e-04194263af08047e5728ee8198d2686af6a774f2acfa58ba
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 SMC2 FAM111B

1.91e-04194263cb39850e9577015b6b9834e98c36b412bae7d462
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ESCO2 SMC2 FAM111B

1.91e-04194263a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCellControl-Lymphoid_T/NK-T/NK_proliferative|Control / Disease group, lineage and cell class

ESCO2 SMC2 FAM111B

1.91e-041942639bbb124001fba7450f4639f47f9b720a483e7242
ToppCell3'_v3-Lung-Myeloid_Mac-Cycling_Myeloid-Mac|Lung / Manually curated celltypes from each tissue

ESCO2 SMC2 FAM111B

1.91e-04194263a8ae49157ca3f9e8b3f1750a995aee012dc859b6
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ESCO2 SMC2 FAM111B

1.91e-04194263590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ESCO2 SMC2 FAM111B

1.91e-04194263408597c9aa302a44b112c1d612c21fbb0227a82a
DrugI-Hg

CBFA2T2 B3GNT2 HGS

1.27e-0619263CID000447029
DiseaseStevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine

SMC2 HLA-C

4.51e-0437252EFO_0004276, EFO_0004775, EFO_0006997
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

ARL3 TCF20 RPTOR

6.32e-04200253EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
DiseasePremature atrial contractions

ZNF69 ZNF700

9.96e-0455252HP_0006699
Diseaseautism spectrum disorder, schizophrenia

ARL3 TCF20 HLA-C

2.59e-03327253EFO_0003756, MONDO_0005090
Diseasecognitive function measurement, self reported educational attainment

ZNF799 TCF20 ZNF443

3.26e-03355253EFO_0004784, EFO_0008354
Diseasecancer

SMC2 HLA-C CBFA2T2

4.56e-03400253MONDO_0004992
Diseasecognitive function measurement

ZNF799 TCF20 SMC2 DSP ZNF443

6.34e-031434255EFO_0008354

Protein segments in the cluster

PeptideGeneStartEntry
LQRRYWSNYVDLEQK

CALHM3

211

Q86XJ0
QRKIRPYWKNYFENT

ARL3

71

P36405
EKPQENKTWREQYLR

ELOA2

596

Q8IYF1
YRIYWKERDSNSQPQ

IL12RB2

556

Q99665
PEYWDRETQKYKRQA

HLA-C

81

P10321
EELNYWKRRYNENTE

CBFA2T2

381

O43439
NEKLERNREYTYQWL

LRRIQ1

1621

Q96JM4
WEKTRYRNVKRNYNA

PRDM9

46

Q9NQV7
RWEYENELSKVRNNY

DSP

1341

P15924
FYNQNKWYLNPLERK

ESCO2

86

Q56NI9
QYPNFKEEAQWVRKY

FAM111B

401

Q6SJ93
RGFNKVWREQNEKYY

SIN3A

711

Q96ST3
YKYKNEQGWRRFDLQ

SMARCC1

126

Q92922
LQKQYENWQPRARYK

RPTOR

106

Q8N122
EAYWNREQEKLNRQY

B3GNT2

56

Q9NY97
YNDEPWYNQKTQKER

ATP11C

321

Q8NB49
KWSDQNIEYEYQNPR

ZNF700

66

Q9H0M5
LARYLNRNYWEKKQE

HGS

326

O14964
KWKDQNIEDQYRYPR

ZNF799

46

Q96GE5
KRQMYQQQPEEYKDW

TCF20

1086

Q9UGU0
LRFAYKDPEKNWNRN

SMC2

506

O95347
KWKDQNIEDQYRYPR

ZNF443

46

Q9Y2A4
SWKDQNIEYEYQNPR

ZNF69

66

Q9UC07
DFWRKMYLREPQNYQ

ZNF233

181

A6NK53
KWKDQNIEYEYQNPR

ZNF763

46

Q0D2J5
KWKDQNIEYEYQNPR

ZNF439

61

Q8NDP4