Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coactivator activity	BCL9L NCOA6 KMT2D BRD4 MED12L RERE ZMIZ1 BCL9 PRDM16	1.31e-07	303	55	9	GO:0003713
GeneOntologyMolecularFunction	transcription coregulator activity	BCL9L NCOA6 KMT2D BRD4 MED12L RERE ZMIZ1 BCL9 PRDM16	2.08e-05	562	55	9	GO:0003712
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	BCL9L NCOA6 KMT2D RBM33 RPTOR BRD4 MED12L RERE ZMIZ1 BCL9 PRDM16	2.73e-04	1160	55	11	GO:0030674
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HIVEP3 HNF1A KMT2D BCL11B AEBP1 ZNF652 BARHL2 YLPM1 ZBTB22 ETV5 PRDM16 CASZ1	3.79e-04	1412	55	12	GO:0000981
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	HNF1A KMT2D BCL11B BARHL2 ETV5 PRDM16 CASZ1	8.31e-04	560	55	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	HNF1A KMT2D BCL11B BARHL2 ETV5 PRDM16 CASZ1	8.84e-04	566	55	7	GO:0001216
GeneOntologyMolecularFunction	molecular adaptor activity	BCL9L NCOA6 KMT2D RBM33 RPTOR BRD4 MED12L RERE ZMIZ1 BCL9 PRDM16	1.02e-03	1356	55	11	GO:0060090
GeneOntologyMolecularFunction	SMAD binding	DROSHA ZMIZ1 PRDM16	1.72e-03	86	55	3	GO:0046332
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	BCL9L NCOA6 HNF1A KMT2D BCL11B BRD4 BARHL2 MED12L CHCHD2 ETV5 SSBP2 ZMIZ1 BCL9 PRDM16 PHIP CASZ1	5.26e-07	1390	56	16	GO:0045944
HumanPheno	Diagnostic behavioral phenotype	KMT2D BCL11B RBM12 BRD4 SBF2 PCDH15 MED12L RERE ZMIZ1 USH2A PRDM16 CASZ1 MFF PHF21A	5.90e-06	747	27	14	HP:0025783
HumanPheno	Polyphagia	HNF1A RERE PRDM16 MN1 CASZ1	4.59e-05	78	27	5	HP:0002591
HumanPheno	Bifid ribs	RERE PRDM16 CASZ1	8.60e-05	17	27	3	HP:0000892
HumanPheno	Rib fusion	BRD4 RERE PRDM16 CASZ1	1.04e-04	48	27	4	HP:0000902
Domain	BCL9_beta-catenin-bd_dom	BCL9L BCL9	9.48e-06	2	58	2	IPR024670
Domain	BCL9	BCL9L BCL9	9.48e-06	2	58	2	PF11502
Domain	Bcl-9	BCL9L BCL9	9.48e-06	2	58	2	IPR015668
Domain	BROMODOMAIN_1	BRD4 PHIP BRWD3	2.05e-04	37	58	3	PS00633
Domain	Bromodomain	BRD4 PHIP BRWD3	2.22e-04	38	58	3	PF00439
Domain	BROMODOMAIN_2	BRD4 PHIP BRWD3	2.79e-04	41	58	3	PS50014
Domain	BROMO	BRD4 PHIP BRWD3	2.99e-04	42	58	3	SM00297
Domain	Bromodomain	BRD4 PHIP BRWD3	2.99e-04	42	58	3	IPR001487
Domain	-	BRD4 PHIP BRWD3	2.99e-04	42	58	3	1.20.920.10
Domain	NPIP	NPIPB15 NPIPB9	8.42e-04	14	58	2	IPR009443
Domain	UDENN	SBF2 DENND4C	1.11e-03	16	58	2	PS50946
Domain	DDENN	SBF2 DENND4C	1.11e-03	16	58	2	PS50947
Domain	DENN	SBF2 DENND4C	1.11e-03	16	58	2	SM00799
Domain	dDENN	SBF2 DENND4C	1.11e-03	16	58	2	SM00801
Domain	DENN	SBF2 DENND4C	1.11e-03	16	58	2	PF02141
Domain	dDENN_dom	SBF2 DENND4C	1.11e-03	16	58	2	IPR005112
Domain	uDENN_dom	SBF2 DENND4C	1.11e-03	16	58	2	IPR005113
Domain	dDENN	SBF2 DENND4C	1.11e-03	16	58	2	PF03455
Domain	DENN	SBF2 DENND4C	1.11e-03	16	58	2	PS50211
Domain	DENN_dom	SBF2 DENND4C	1.11e-03	16	58	2	IPR001194
Domain	Bromodomain_CS	BRD4 PHIP	2.94e-03	26	58	2	IPR018359
Domain	SET	KMT2D PRDM16	8.99e-03	46	58	2	SM00317
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	BCL9L KMT2D BCL9	4.50e-05	26	38	3	MM14793
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	BCL9L KMT2D BCL9	1.93e-04	42	38	3	M27272
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	BCL9L NCOA6 KMT2D RBM12 CHERP RBM33 BRD4 YLPM1 SSBP2 RERE BCL9 CASZ1 PHF21A	2.34e-15	268	64	13	33640491
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L NCOA6 KMT2D BCL11B SSBP2 RERE ZMIZ1 BCL9 PRDM16 PHF21A	9.01e-10	351	64	10	38297188
Pubmed	Human transcription factor protein interaction networks.	BCL9L NCOA6 HNF1A KMT2D RBM12 FAM120A RBM33 CNOT10 YLPM1 ETV5 SSBP2 RERE ZMIZ1 BCL9 PRDM16 PHF21A	4.60e-09	1429	64	16	35140242
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ATXN2L NCOA6 KMT2D RBM12 FAM120A RBM33 ZNF652 BRD4 ETV5 CSTF3 BCL9 PHF21A	7.00e-07	1103	64	12	34189442
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN2L NCOA6 KMT2D RPTOR BRD4 YLPM1 RIMS1 RERE BCL9 MN1	1.44e-06	774	64	10	15302935
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	BCL9L NCOA6 KMT2D RBM12 RBM33 YLPM1 ZMIZ1 BCL9	1.94e-06	457	64	8	32344865
Pubmed	A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.	BCL9L AMELX BCL9	2.13e-06	14	64	3	28174279
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2D RBM12 YLPM1 CSTF3 RERE CASZ1	3.30e-06	220	64	6	35785414
Pubmed	Partial USH2A deletions contribute to Usher syndrome in Denmark.	PCDH15 USH2A	3.33e-06	2	64	2	25804404
Pubmed	Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.	BCL9L BCL9	3.33e-06	2	64	2	38811552
Pubmed	Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia.	HNF1A BCL11B	3.33e-06	2	64	2	36211334
Pubmed	Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.	BCL9L BCL9	3.33e-06	2	64	2	15371335
Pubmed	Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.	BCL9L BCL9	3.33e-06	2	64	2	20682801
Pubmed	BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.	BCL9L BCL9	3.33e-06	2	64	2	33767438
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATXN2L RBM12 RBM33 ZMIZ1 BCL9	9.24e-06	152	64	5	38360978
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	VGF BCL11B FAM120A FAM171A2 NUMBL RPTOR YLPM1 ZBTB22 RIMS1 BCL9	9.89e-06	963	64	10	28671696
Pubmed	Discovery of a hidden transient state in all bromodomain families.	BRD4 PHIP	9.99e-06	3	64	2	33468647
Pubmed	The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.	BCL9L BCL9	9.99e-06	3	64	2	34545187
Pubmed	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.	BCL9L BCL9	9.99e-06	3	64	2	33649334
Pubmed	Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.	BCL9L BCL9	9.99e-06	3	64	2	20637214
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIVEP3 FAM120A NUMBL RPTOR SBF2 CSTF3 PARD3B RIMS1 RERE ZMIZ1 CASZ1 BRWD3	1.51e-05	1489	64	12	28611215
Pubmed	The functional interactome landscape of the human histone deacetylase family.	BCL11B YLPM1 ETV5 RERE PHIP PHF21A	1.56e-05	289	64	6	23752268
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	PCDH15 USH2A	2.00e-05	4	64	2	18463160
Pubmed	Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.	KMT2D PCDH15	2.00e-05	4	64	2	16972005
Pubmed	BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.	BCL9L BCL9	2.00e-05	4	64	2	19699733
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	BCL9L CHERP RBM33 YLPM1 BCL9	2.09e-05	180	64	5	35198878
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 NCOA6 KMT2D RPTOR BRD4 SBF2 BCL9 DYSF PRDM16 CASZ1	3.21e-05	1105	64	10	35748872
Pubmed	LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.	BCL9L BCL9	3.32e-05	5	64	2	24360964
Pubmed	TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.	BCL9L BCL9	3.32e-05	5	64	2	32808927
Pubmed	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.	BCL9L BCL9	3.32e-05	5	64	2	30760710
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	PCDH15 USH2A	3.32e-05	5	64	2	16301216
Pubmed	Crystal structure of a beta-catenin/BCL9/Tcf4 complex.	BCL9L BCL9	3.32e-05	5	64	2	17052462
Pubmed	A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.	BCL9L BCL9	3.32e-05	5	64	2	19328798
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BCL11B FAM120A DROSHA RPTOR BRD4 RERE PRDM16 PHIP BRWD3 PHF21A	3.49e-05	1116	64	10	31753913
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	GORASP2 PARD3B RIMS1	3.73e-05	35	64	3	33864728
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	HNF1A BCL11B BRD4 ZBTB22 ETV5 PRDM16 PHIP PHF21A	4.64e-05	709	64	8	22988430
Pubmed	BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.	BCL9L BCL9	4.98e-05	6	64	2	17113272
Pubmed	Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.	JRK BCL9	4.98e-05	6	64	2	21399610
Pubmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.	BCL9L BCL9	4.98e-05	6	64	2	30760720
Pubmed	Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.	BCL9L BCL9	4.98e-05	6	64	2	15574752
Pubmed	Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.	BCL9L BCL9	4.98e-05	6	64	2	25184676
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	KMT2D CHERP	4.98e-05	6	64	2	8896557
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	NCOA6 KMT2D	4.98e-05	6	64	2	17021013
Pubmed	Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.	BCL9L BCL9	6.96e-05	7	64	2	30366904
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	PCDH15 USH2A	6.96e-05	7	64	2	20058854
Pubmed	Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.	ATXN2L ZMIZ1	6.96e-05	7	64	2	20473688
Pubmed	Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst.	DROSHA CHCHD2	6.96e-05	7	64	2	9502196
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	NCOA6 KMT2D	6.96e-05	7	64	2	19556342
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KMT2D BCL11B BRD4 PRDM16 CASZ1 PHF21A	9.26e-05	398	64	6	35016035
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	PCDH15 USH2A	9.27e-05	8	64	2	19683999
Pubmed	Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.	NCOA6 KMT2D	9.27e-05	8	64	2	17178841
Pubmed	UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.	PCDH15 USH2A	9.27e-05	8	64	2	18484607
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	PCDH15 USH2A	9.27e-05	8	64	2	16545802
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	BCL9L BCL9	9.27e-05	8	64	2	28296634
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	ATXN2L RBM12 CHERP RBM33 BRD4 YLPM1	9.39e-05	399	64	6	35987950
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	RBM12 CHERP RBM33 BRD4	9.95e-05	130	64	4	35545047
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ATXN2L RBM12 CHERP FAM120A RBM33 DROSHA YLPM1 CSTF3	1.14e-04	807	64	8	22681889
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIVEP3 HNF1A BRD4 JRK ZBTB22 ETV5 PRDM16 PHF21A	1.15e-04	808	64	8	20412781
Pubmed	Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.	KMT2D PCDH15	1.19e-04	9	64	2	35296311
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	PCDH15 USH2A	1.19e-04	9	64	2	23144817
Pubmed	Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis.	AMELX BCL11B	1.19e-04	9	64	2	19251658
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2D BRD4 RERE ZMIZ1 DENND4C PHF21A	1.21e-04	418	64	6	34709266
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	NUMBL BRD4 MED12L PTPN23 DYSF PHIP	1.23e-04	419	64	6	33001583
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	CELF4 PCDH15 RIMS1 PRDM16 MN1	1.31e-04	265	64	5	19240061
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	PCDH15 USH2A	1.49e-04	10	64	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	PCDH15 USH2A	1.49e-04	10	64	2	24239741
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	NCOA6 DROSHA	1.49e-04	10	64	2	20721975
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PCED1B CHERP NUMBL DROSHA BRD4 YLPM1 PCDH15 CSTF3 SSBP2	1.57e-04	1082	64	9	38697112
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L NCOA6 FAM171A2 NUMBL RPTOR BRD4 PARD3B DENND4C	1.78e-04	861	64	8	36931259
Pubmed	Oxidative stress regulates progenitor behavior and cortical neurogenesis.	BCL11B PRDM16	1.81e-04	11	64	2	32041791
Pubmed	De novo genic mutations among a Chinese autism spectrum disorder cohort.	HIVEP3 RIMS1	2.17e-04	12	64	2	27824329
Pubmed	Common variants at five new loci associated with early-onset inflammatory bowel disease.	ATXN2L ZMIZ1	2.17e-04	12	64	2	19915574
Pubmed	PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.	BCL9 PRDM16	2.17e-04	12	64	2	35132438
Pubmed	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation.	KMT2D PRDM16	2.17e-04	12	64	2	33712604
Pubmed	Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.	VGF BCL11B	2.17e-04	12	64	2	35613048
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BCL9L KMT2D FAM120A BRD4 PARD3B PHIP	2.25e-04	469	64	6	27634302
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	NCOA6 KMT2D PHF21A	2.39e-04	65	64	3	22496869
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	NCOA6 KMT2D	2.57e-04	13	64	2	17761849
Pubmed	An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.	AMELX ETV5	2.57e-04	13	64	2	18077585
Pubmed	Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.	AMELX ETV5	2.57e-04	13	64	2	25376721
Pubmed	Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.	VGF BCL11B	2.57e-04	13	64	2	35289744
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HIVEP3 FAM120A SBF2 PTPN23 PRDM16 CASZ1	2.94e-04	493	64	6	15368895
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	NCOA6 KMT2D	2.99e-04	14	64	2	12482968
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ATXN2L GORASP2 RBM12 CHERP NUMBL YLPM1 PTPN23 PHF21A	3.07e-04	934	64	8	33916271
Pubmed	The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.	BCL11B RPTOR	3.45e-04	15	64	2	34381067
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	NCOA6 KMT2D	3.45e-04	15	64	2	17925232
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ATXN2L NCOA6 CHERP RBM33 BRD4 YLPM1 CSTF3 PHIP	3.54e-04	954	64	8	36373674
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	HAVCR1 HNF1A ETV5	3.65e-04	75	64	3	20571754
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BCL9L GORASP2 NUMBL RBM33 DROSHA CNOT10 ZNF652 CSTF3 CASZ1 MFF	3.85e-04	1497	64	10	31527615
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ATXN2L GORASP2 CHERP FAM120A RBM33 YLPM1 DENND4C	3.93e-04	733	64	7	34672954
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	NCOA6 KMT2D	3.93e-04	16	64	2	24368734
Pubmed	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	TBXAS1 PRDM16 CASZ1	4.10e-04	78	64	3	23793025
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	NCOA6 KMT2D	4.45e-04	17	64	2	26180087
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA6 KMT2D BCL9	4.92e-04	83	64	3	28794006
Pubmed	Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2.	NCOA6 RBM12	5.00e-04	18	64	2	15769905
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	RERE MN1	5.00e-04	18	64	2	26921296
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	NCOA6 KMT2D	5.00e-04	18	64	2	17500065
Pubmed	Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.	BCL11B NUMBL	5.00e-04	18	64	2	17589506
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L NCOA6 KMT2D BRD4 YLPM1 PTPN23	5.20e-04	549	64	6	38280479
Pubmed	BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.	AMELX BCL11B	5.59e-04	19	64	2	22629441
Interaction	EGR2 interactions	BCL9L NCOA6 KMT2D BCL11B SSBP2 RERE BCL9 PRDM16 PHF21A	1.88e-09	171	60	9	int:EGR2
Interaction	AR interactions	BCL9L NCOA6 KMT2D RBM12 CHERP RBM33 BRD4 YLPM1 MED12L ETV5 CSTF3 SSBP2 RERE ZMIZ1 BCL9 CASZ1 PHF21A	2.67e-09	992	60	17	int:AR
Interaction	SP7 interactions	BCL9L NCOA6 KMT2D RBM12 RBM33 YLPM1 RERE ZMIZ1 BCL9	2.71e-07	304	60	9	int:SP7
Interaction	H3C14 interactions	NCOA6 KMT2D BRD4 RERE PRDM16 PHIP PHF21A	3.98e-07	156	60	7	int:H3C14
Interaction	SMG7 interactions	NCOA6 KMT2D RBM12 FAM120A RBM33 YLPM1 CSTF3 BCL9 PHIP	4.06e-07	319	60	9	int:SMG7
Interaction	TLE3 interactions	BCL9L KMT2D BCL11B RBM12 CHERP BRD4 RERE ZMIZ1 BCL9	1.59e-06	376	60	9	int:TLE3
Interaction	PHIP interactions	BCL11B FAM120A BRD4 RERE PRDM16 PHIP BRWD3	1.91e-06	197	60	7	int:PHIP
Interaction	NUP35 interactions	HIVEP3 BCL9L NCOA6 KMT2D RBM12 RBM33 YLPM1 ZMIZ1 BCL9	4.24e-06	424	60	9	int:NUP35
Interaction	SOX7 interactions	KMT2D BCL11B PRDM16 CASZ1 PHF21A	4.52e-06	82	60	5	int:SOX7
Interaction	GSC interactions	BCL9L KMT2D RERE BCL9 PRDM16	6.05e-06	87	60	5	int:GSC
Interaction	KDM6A interactions	NCOA6 HNF1A KMT2D BRD4 ETV5 RERE	8.60e-06	162	60	6	int:KDM6A
Interaction	ALG13 interactions	KMT2D RBM12 FAM120A RBM33 RERE BCL9	1.72e-05	183	60	6	int:ALG13
Interaction	TBR1 interactions	BCL9L KMT2D BRD4 ZMIZ1 BCL9	2.17e-05	113	60	5	int:TBR1
Interaction	KMT2B interactions	NCOA6 KMT2D DROSHA RERE PHF21A	4.25e-05	130	60	5	int:KMT2B
Interaction	CEBPA interactions	ATXN2L NCOA6 HNF1A KMT2D RBM12 FAM120A RBM33 ZNF652 BRD4 ETV5 CSTF3 BCL9 PHF21A	6.07e-05	1245	60	13	int:CEBPA
Interaction	PYGO1 interactions	BCL9L SSBP2 BCL9	7.79e-05	28	60	3	int:PYGO1
Interaction	TOP3B interactions	HIVEP3 NCOA6 GORASP2 KMT2D FAM120A RBM33 CNOT10 RPTOR BRD4 SBF2 BCL9 DYSF PRDM16 CASZ1	8.14e-05	1470	60	14	int:TOP3B
Interaction	CRX interactions	BCL9L KMT2D RERE ZMIZ1 BCL9 PRDM16	1.07e-04	254	60	6	int:CRX
Interaction	TAF1 interactions	KMT2D BRD4 RERE DYSF PHIP PHF21A	1.22e-04	260	60	6	int:TAF1
Interaction	ETV5 interactions	KMT2D ETV5 SEZ6L2	1.28e-04	33	60	3	int:ETV5
Interaction	LHX4 interactions	BCL9L KMT2D CHCHD2 SSBP2 BCL9	1.35e-04	166	60	5	int:LHX4
Interaction	KMT2D interactions	NCOA6 HNF1A KMT2D ETV5 PHF21A	1.47e-04	169	60	5	int:KMT2D
Interaction	GATA1 interactions	KMT2D RBM12 BRD4 ZBTB22 BCL9	1.55e-04	171	60	5	int:GATA1
Interaction	PRMT2 interactions	NCOA6 RBM12 YLPM1 CHCHD2P9	1.56e-04	91	60	4	int:PRMT2
Interaction	SOX9 interactions	NCOA6 KMT2D BRD4 BCL9	2.00e-04	97	60	4	int:SOX9
Interaction	CELF1 interactions	RBM12 FAM120A RBM33 BRD4 YLPM1 CSTF3	2.12e-04	288	60	6	int:CELF1
Interaction	ISL1 interactions	BCL9L SSBP2 BCL9	2.47e-04	41	60	3	int:ISL1
Interaction	ISL2 interactions	BCL9L SSBP2 BCL9	2.47e-04	41	60	3	int:ISL2
Interaction	FUBP3 interactions	RBM12 FAM120A RBM33 CNOT10 BRD4 YLPM1	2.50e-04	297	60	6	int:FUBP3
Interaction	ZMYND8 interactions	BCL11B CHERP BRD4 RERE PHF21A	2.60e-04	191	60	5	int:ZMYND8
Cytoband	20q11.21	C20orf203 RBM12	1.99e-03	47	64	2	20q11.21
Cytoband	19p13.1	CHERP BRD4	2.07e-03	48	64	2	19p13.1
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D NUMBL	1.32e-03	25	39	2	775
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	SBF2 DENND4C	1.32e-03	25	39	2	504
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D PRDM16	2.44e-03	34	39	2	487
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HIVEP3 BCL11B ZNF652 ZBTB22 PRDM16 CASZ1	4.09e-03	718	39	6	28
GeneFamily	PDZ domain containing	GORASP2 PARD3B RIMS1	4.27e-03	152	39	3	1220
GeneFamily	RNA binding motif containing	CELF4 RBM12 RBM33	1.08e-02	213	39	3	725
GeneFamily	PHD finger proteins	KMT2D PHF21A	1.61e-02	90	39	2	88
GeneFamily	WD repeat domain containing	RPTOR PHIP BRWD3	1.87e-02	262	39	3	362
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	HIVEP3 CELF4 BCL11B MED12L RIMS1 SEZ6L2 USH2A CASZ1	1.19e-05	465	61	8	M39066
Disease	Intellectual Disability	BCL11B BRD4 MED12L PTPN23 ZMIZ1 MN1 PHIP BRWD3 PHF21A	2.89e-07	447	60	9	C3714756
Disease	forced expiratory volume	TBXAS1 ATXN2L NCOA6 DROSHA PCDH15 PARD3B BCL9 MN1 PHIP CASZ1	3.98e-06	789	60	10	EFO_0004314
Disease	irritable bowel syndrome	CELF4 FAM120A YLPM1 PCDH15 RERE	7.17e-06	131	60	5	EFO_0000555
Disease	frontotemporal dementia and/or amyotrophic lateral sclerosis-2 (implicated_via_orthology)	CHCHD2 CHCHD2P9	1.22e-05	3	60	2	DOID:0060214 (implicated_via_orthology)
Disease	Parkinson's disease 22 (implicated_via_orthology)	CHCHD2 CHCHD2P9	1.22e-05	3	60	2	DOID:0080504 (implicated_via_orthology)
Disease	spinal muscular atrophy, Jokela type (implicated_via_orthology)	CHCHD2 CHCHD2P9	1.22e-05	3	60	2	DOID:0081356 (implicated_via_orthology)
Disease	Antihypertensive use measurement	C20orf203 PCED1B SBF2 PRDM16 PHIP CASZ1	1.65e-05	265	60	6	EFO_0009927
Disease	cognitive function measurement	ATXN2L CELF4 KMT2D BCL11B FAM120A CNOT10 BARHL2 MED12L PARD3B SSBP2 USH2A CHCHD2P9	2.65e-05	1434	60	12	EFO_0008354
Disease	Chromosome 1p36 Deletion Syndrome	RERE PRDM16	4.05e-05	5	60	2	C1842870
Disease	Usher Syndrome, Type II	PCDH15 USH2A	4.05e-05	5	60	2	C1568249
Disease	reaction time measurement	CELF4 KMT2D BRD4 PARD3B RIMS1 RERE DYSF PHF21A	5.40e-05	658	60	8	EFO_0008393
Disease	neurotic disorder	CELF4 FAM120A YLPM1 RERE	5.44e-05	101	60	4	EFO_0004257
Disease	Abnormal corpus callosum morphology	MED12L MN1	6.07e-05	6	60	2	C1842581
Disease	mean arterial pressure	HIVEP3 RPTOR ZNF652 RERE PRDM16 PHIP CASZ1	6.75e-05	499	60	7	EFO_0006340
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	HIVEP3 ATXN2L RPTOR YLPM1 PARD3B RERE	9.66e-05	364	60	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	isovalerate measurement	PRRT1B USH2A	1.45e-04	9	60	2	EFO_0021051
Disease	Abnormality of the face	BRD4 MN1	1.45e-04	9	60	2	C4025871
Disease	neuroticism measurement, cognitive function measurement	ATXN2L CELF4 BCL11B FAM120A YLPM1 SSBP2 RERE	1.48e-04	566	60	7	EFO_0007660, EFO_0008354
Disease	alcohol consumption measurement	ATXN2L HNF1A BCL11B NPIPB9 RPTOR CSTF3 RERE SEZ6L2 CHCHD2P9 PRDM16	1.86e-04	1242	60	10	EFO_0007878
Disease	advanced glycosylation end product-specific receptor, soluble measurement	PRRT1B PRDM16	3.13e-04	13	60	2	EFO_0020131
Disease	sexual dimorphism measurement	ATXN2L NCOA6 HNF1A PTPN23 ZMIZ1 DYSF SEZ6L2 PHIP PHF21A	3.74e-04	1106	60	9	EFO_0021796
Disease	pulse pressure measurement	TBXAS1 HIVEP3 FAM171A2 RBM33 RPTOR SBF2 DYSF PRDM16 CASZ1 DENND4C	4.62e-04	1392	60	10	EFO_0005763
Disease	body fat percentage	HIVEP3 ATXN2L RPTOR YLPM1 PARD3B RERE	4.67e-04	488	60	6	EFO_0007800
Disease	nervousness	CELF4 YLPM1	4.79e-04	16	60	2	NCIT_C74532
Disease	smoking status measurement	CELF4 BCL11B BARHL2 PCDH15 MED12L RIMS1 RERE USH2A PHF21A	5.29e-04	1160	60	9	EFO_0006527
Disease	myeloid white cell count	TBXAS1 HIVEP3 HAVCR1 HNF1A SBF2 MED12L RERE BCL9	5.95e-04	937	60	8	EFO_0007988
Disease	Feeding difficulties	ZMIZ1 MN1	6.09e-04	18	60	2	C0232466
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	BCL11B RPTOR RIMS1 RERE	7.42e-04	200	60	4	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	risk-taking behaviour	HIVEP3 BCL11B BARHL2 PCDH15 PARD3B SSBP2 PHF21A	8.90e-04	764	60	7	EFO_0008579
Disease	Neurodevelopmental Disorders	HIVEP3 PARD3B RIMS1	9.11e-04	93	60	3	C1535926
Disease	S-6-hydroxywarfarin measurement	RPTOR PCDH15 DYSF CHCHD2P9 DENND4C	9.14e-04	368	60	5	EFO_0803326
Disease	executive function measurement	BCL11B BARHL2 PCDH15 SSBP2 RIMS1	1.01e-03	376	60	5	EFO_0009332
Disease	testosterone measurement	ATXN2L NCOA6 HNF1A BCL11B ZNF652 SBF2 ZMIZ1 USH2A PHIP	1.04e-03	1275	60	9	EFO_0004908
Disease	hearing impairment	PCDH15 USH2A MN1	1.06e-03	98	60	3	C1384666
Disease	airway responsiveness measurement	RPTOR PCDH15	1.09e-03	24	60	2	EFO_0006897
Disease	bipolar disorder	KMT2D BCL11B RPTOR SSBP2 RIMS1 ZMIZ1	1.11e-03	577	60	6	MONDO_0004985
Disease	anterior thigh muscle fat infiltration measurement	ATXN2L DYSF	1.49e-03	28	60	2	EFO_0020936
Disease	glomerular filtration rate, response to platinum based chemotherapy	RERE BCL9	1.49e-03	28	60	2	EFO_0004647, EFO_0005208
Disease	triglyceride measurement, intermediate density lipoprotein measurement	HAVCR1 HNF1A RBM12	1.52e-03	111	60	3	EFO_0004530, EFO_0008595
Disease	Prostatic Neoplasms	TBXAS1 KMT2D BRD4 ETV5 SSBP2 CASZ1	1.56e-03	616	60	6	C0033578
Disease	Malignant neoplasm of prostate	TBXAS1 KMT2D BRD4 ETV5 SSBP2 CASZ1	1.56e-03	616	60	6	C0376358
Disease	cerebral infarction (is_implicated_in)	TBXAS1 HNF1A	1.59e-03	29	60	2	DOID:3526 (is_implicated_in)
Disease	caudate nucleus volume	ATXN2L PRDM16	1.71e-03	30	60	2	EFO_0004830
Disease	granulocyte count	HNF1A RERE ZMIZ1 BCL9	1.79e-03	254	60	4	EFO_0007987
Disease	waist circumference	PCED1B ATXN2L ETV5 ZMIZ1 PHIP	1.80e-03	429	60	5	EFO_0004342
Disease	neutrophil count	HIVEP3 HAVCR1 HNF1A BCL11B SBF2 RERE ZMIZ1 BCL9 CASZ1	1.81e-03	1382	60	9	EFO_0004833

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHQPMQPQPPVHPMQ	AMELX	136	Q99217
PPHVPPQMLNIPQTS	C9orf129	6	Q5T035
QPPPRPVHLQPMQFS	BRD4	991	O60885
PMQFSTHIQQPPPPQ	BRD4	1001	O60885
IPQMPQIPASVPHLP	CASZ1	1126	Q86V15
PIPHIDPSRPMTPQQ	AEBP1	1001	Q8IUX7
QTQQAPHLMPPPFLV	BRWD3	576	Q6RI45
QMRAAPRPAPVAQPP	CHCHD2	21	Q9Y6H1
GAPHPPQVMLLHPPQ	ATXN2L	981	Q8WWM7
QVAVFLPPPHMQPPF	NUMBL	476	Q9Y6R0
NLNPMFLGPLNPVNP	RBM12	271	Q9NTZ6
PPPLMPMSQPQFRPH	RBM33	646	Q96EV2
QLIQPRAPGPHAMPV	PTPN23	801	Q9H3S7
RQDVPPSPPQHQRMP	PARD3B	1156	Q8TEW8
HPNLPSVPLPQDPMR	MED12L	2036	Q86YW9
PNLNLNLPAPHIMPG	GORASP2	316	Q9H8Y8
PSPQQARVCPPHMLP	MFF	201	Q9GZY8
ENPNPHMAFQKVPRP	SBF2	466	Q86WG5
LPQPPNMLDHRQWPP	C20orf203	16	Q8NBC4
PPVPLQGPHARYNMN	JRK	346	O75564
LSPQPPPPILHHQGM	PCED1B	316	Q96HM7
PPPILHHQGMPRFPQ	PCED1B	321	Q96HM7
TQQMIPFQPRHLAPP	CSTF3	586	Q12996
QNNIPIAPAPPPMLA	PHF21A	241	Q96BD5
QPLHPSYQQPLMPPV	HNF1A	466	P20823
FAVPRPPHQPLQMPK	ETV5	191	P41161
VPPHVPPQMLNIPQT	FAM120A	356	Q9NZB2
NRMGRQPPPPTQQHS	NPIPB7	241	O75200
NRMGRQPPPPTQQHS	NPIPB15	241	A6NHN6
PLPQPSPFMPRRHIH	RIMS1	876	Q86UR5
FPQPDPQRPQMPGHS	FAM171A2	576	A8MVW0
QVLRPPGPSPHMAQQ	NCOA6	786	Q14686
PPQHLSPPQPGRVRM	PANO1	171	I0J062
LPPNNQSPPRFPQLM	PCDH15	606	Q96QU1
QMRAAPRPAPVAQPP	CHCHD2P9	21	Q5T1J5
NPMHRLLNPFQPSPK	BCL11B	386	Q9C0K0
MQRPPHFRGPFPPHQ	CHERP	516	Q8IWX8
QMPSPNAVGPNIPPH	BCL9	1091	O00512
PGQQPLSHEPPPAML	BCL9L	1161	Q86UU0
GPPPQQNLMVSHPLR	BCL9L	1461	Q86UU0
HFMQNIPFPSPQRPR	DENND4C	351	Q5VZ89
MYRTPPAPHPQLQRP	BARHL2	341	Q9NY43
PMPPRQFHQLAAQGP	DYSF	1561	O75923
NRMGRQPPPPTQQHS	NPIPB9	256	F8W1W9
VGSRHPLMQPPQQAP	MN1	331	Q10571
PVSPRLHVPLMPAQP	F12	306	P00748
QTPEIAPLMQPPPHL	USH2A	4626	O75445
CPIRPPFPNHQMRHP	DROSHA	96	Q9NRR4
PFPNHQMRHPFPVPP	DROSHA	101	Q9NRR4
LMNAVPPGPNRPNFP	SSBP2	271	P81877
APLPPPAPSQFQARM	VGF	221	O15240
QVCPARMPQQPPLHY	PRDM16	841	Q9HAZ2
RMPQQPPLHYAKPSP	PRDM16	846	Q9HAZ2
FVPPMPLPRQNHEPV	HAVCR1	211	Q96D42
QGHLLPPCLLPPPQM	MRGPRG-AS1	46	Q2M3A8
PSAHPPPLQLMPQSQ	RERE	981	Q9P2R6
MGTPRAQHPPPPQLL	SEZ6L2	1	Q6UXD5
AINPNHPLAQMPLPP	RPTOR	221	Q8N122
QAFPQPPPMIPQQQR	CELF4	401	Q9BZC1
KPVFQPVHPIQPIQM	CNOT10	721	Q9H9A5
PNPSRQHQPSPMARP	TBXAS1	311	P24557
EQTQQAPHLMPPPFL	PHIP	576	Q8WWQ0
QSMPHRKPVPHPNPT	SPATA31D1	1516	Q6ZQQ2
PQLMPHPANIPFRQP	HIVEP3	1206	Q5T1R4
QMQCVLQPHHLPPPP	YLPM1	71	P49750
NMNPVSTLPPRPIPH	ZNF652	531	Q9Y2D9
PQMPAQPALPQLPRR	PRRT1B	36	A0A1B0GWB2
HPPRPLLPLDMQGNQ	ZBTB22	411	O15209
PNMSALPPPPANHND	ZMIZ1	546	Q9ULJ6
PQPLMPTQPPAHALQ	KMT2D	3326	O14686