Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	palmitoyl-CoA ligase activity	ACSL3 ACSL4	4.05e-05	3	74	2	GO:0090433
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	8.09e-05	4	74	2	GO:0047718
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	8.09e-05	4	74	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	8.09e-05	4	74	2	GO:0045703
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	8.09e-05	4	74	2	GO:0047743
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSL3 ACSL4 ACSM5	1.19e-04	26	74	3	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSL3 ACSL4 ACSM5	1.34e-04	27	74	3	GO:0016405
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0047115
GeneOntologyMolecularFunction	2'-5'-oligoadenylate synthetase activity	OAS2 OAS3	1.35e-04	5	74	2	GO:0001730
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0047006
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0047787
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	1.35e-04	5	74	2	GO:0047086
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	2.01e-04	6	74	2	GO:0045550
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSL3 ACSL4 ACSM5	2.04e-04	31	74	3	GO:0016878
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	2.81e-04	7	74	2	GO:0072582
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	3.74e-04	8	74	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	3.74e-04	8	74	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	3.74e-04	8	74	2	GO:0035671
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSL3 ACSL4 ACSM5	4.71e-04	41	74	3	GO:0016877
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	4.80e-04	9	74	2	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	4.80e-04	9	74	2	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	5.98e-04	10	74	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	5.98e-04	10	74	2	GO:0032052
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSL3 ACSM5	7.29e-04	11	74	2	GO:0031956
GeneOntologyMolecularFunction	arachidonate-CoA ligase activity	ACSL3 ACSL4	7.29e-04	11	74	2	GO:0047676
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C1 AKR1C2	1.20e-03	14	74	2	GO:0001758
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1C1 AKR1C2	1.20e-03	14	74	2	GO:0004032
GeneOntologyMolecularFunction	long-chain fatty acid-CoA ligase activity	ACSL3 ACSL4	1.38e-03	15	74	2	GO:0004467
GeneOntologyMolecularFunction	estradiol 17-beta-dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2	2.47e-03	20	74	2	GO:0004303
GeneOntologyMolecularFunction	C-acyltransferase activity	SPTLC1 ACSM5	2.72e-03	21	74	2	GO:0016408
GeneOntologyMolecularFunction	cytokine binding	IL12RB2 CD44 TMC8 IL27RA	2.76e-03	157	74	4	GO:0019955
GeneOntologyMolecularFunction	immune receptor activity	IL12RB2 HLA-DOA CD44 IL27RA	3.30e-03	165	74	4	GO:0140375
GeneOntologyMolecularFunction	collagen binding	AEBP1 CD44 USH2A	3.39e-03	81	74	3	GO:0005518
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	AKR1C1 AKR1C2	3.55e-03	24	74	2	GO:0004745
GeneOntologyMolecularFunction	ligase activity	ACSL3 ACSL4 MTHFD1L ACSM5	3.99e-03	174	74	4	GO:0016874
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	AKR1C1 AKR1C2	4.16e-03	26	74	2	GO:0004022
GeneOntologyMolecularFunction	NADPH binding	AKR1C1 AKR1C2	4.16e-03	26	74	2	GO:0070402
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	4.48e-03	27	74	2	GO:0008106
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	AKR1C1 AKR1C2	5.51e-03	30	74	2	GO:0018455
GeneOntologyMolecularFunction	cytokine receptor activity	IL12RB2 CD44 IL27RA	5.61e-03	97	74	3	GO:0004896
GeneOntologyMolecularFunction	adenylyltransferase activity	OAS2 OAS3	5.88e-03	31	74	2	GO:0070566
GeneOntologyMolecularFunction	metallocarboxypeptidase activity	ACE2 AEBP1	5.88e-03	31	74	2	GO:0004181
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR1C1 AKR1C2	6.25e-03	32	74	2	GO:0004033
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	AKR1C1 AKR1C2	6.64e-03	33	74	2	GO:0033764
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	AKR1C1 AKR1C2	7.04e-03	34	74	2	GO:0016628
GeneOntologyBiologicalProcess	regulation of isoprenoid metabolic process	ISX AKR1C1 AKR1C2	5.44e-06	10	75	3	GO:0019747
GeneOntologyBiologicalProcess	regulation of vitamin metabolic process	ISX AKR1C1 AKR1C2	3.62e-05	18	75	3	GO:0030656
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	7.79e-05	4	75	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	7.79e-05	4	75	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	7.79e-05	4	75	2	GO:0071395
GeneOntologyBiologicalProcess	interleukin-27-mediated signaling pathway	OAS2 IL27RA	7.79e-05	4	75	2	GO:0070106
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	7.79e-05	4	75	2	GO:0008208
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:0120256
GeneOntologyBiologicalProcess	lncRNA transcription	NFATC2 ZC3H4	1.30e-04	5	75	2	GO:0140742
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	1.30e-04	5	75	2	GO:1900053
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C1 AKR1C2	1.94e-04	6	75	2	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C1 AKR1C2	1.94e-04	6	75	2	GO:0016095
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C1 AKR1C2	2.71e-04	7	75	2	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C1 AKR1C2	2.71e-04	7	75	2	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	2.71e-04	7	75	2	GO:1900052
GeneOntologyBiologicalProcess	regulation of chaperone-mediated autophagy	ATP13A2 PLK3	3.60e-04	8	75	2	GO:1904714
GeneOntologyBiologicalProcess	daunorubicin metabolic process	AKR1C1 AKR1C2	4.62e-04	9	75	2	GO:0044597
GeneOntologyBiologicalProcess	doxorubicin metabolic process	AKR1C1 AKR1C2	5.76e-04	10	75	2	GO:0044598
GeneOntologyBiologicalProcess	regulation of ribonuclease activity	OAS2 OAS3	5.76e-04	10	75	2	GO:0060700
GeneOntologyBiologicalProcess	negative regulation of vitamin metabolic process	AKR1C1 AKR1C2	5.76e-04	10	75	2	GO:0046137
GeneOntologyBiologicalProcess	polyketide metabolic process	AKR1C1 AKR1C2	5.76e-04	10	75	2	GO:0030638
GeneOntologyBiologicalProcess	aminoglycoside antibiotic metabolic process	AKR1C1 AKR1C2	5.76e-04	10	75	2	GO:0030647
GeneOntologyBiologicalProcess	positive regulation of interferon-beta production	OAS2 OAS3 IRF5	6.67e-04	47	75	3	GO:0032728
GeneOntologyBiologicalProcess	regulation of testosterone biosynthetic process	AKR1C1 AKR1C2	7.02e-04	11	75	2	GO:2000224
GeneOntologyBiologicalProcess	terpenoid catabolic process	AKR1C1 AKR1C2	7.02e-04	11	75	2	GO:0016115
MousePheno	abnormal interleukin level	ACE2 IL12RB2 HDAC6 IL25 TBX21 CD44 APBA3 IRF5 AKR1C1 AKR1C2 IL27RA	4.83e-08	322	56	11	MP:0008751
MousePheno	abnormal T-helper 1 physiology	NFATC2 CD44 IRF5 TRIM27 IL27RA	1.94e-06	52	56	5	MP:0005465
MousePheno	abnormal cytokine level	ACE2 IL12RB2 HDAC6 IL25 TBX21 CD44 APBA3 IRF5 AKR1C1 AKR1C2 IL27RA	2.09e-06	470	56	11	MP:0008713
MousePheno	abnormal intercellular signaling peptide or protein level	ACE2 IL12RB2 HDAC6 IL25 TBX21 CD44 APBA3 IRF5 AKR1C1 AKR1C2 IL27RA	2.57e-06	480	56	11	MP:0008835
MousePheno	respiratory system inflammation	ACE2 KIF27 IL25 TBX21 CD44 AKR1C1 AKR1C2	2.62e-05	220	56	7	MP:0002405
MousePheno	abnormal tumor necrosis factor secretion	MYO1G NFATC2 IL25 CD44 APBA3 IRF5 TRIM27	3.48e-05	230	56	7	MP:0008556
MousePheno	abnormal immune serum protein physiology	MYO1G ACE2 IL12RB2 HDAC6 NFATC2 IL25 HLA-DOA TBX21 CD44 APBA3 IRF5 TRIM27 AKR1C1 AKR1C2 IL27RA	3.68e-05	1165	56	15	MP:0002723
MousePheno	abnormal CD4-positive, alpha-beta T cell physiology	NFATC2 TBX21 CD44 IRF5 TRIM27 IL27RA	4.92e-05	165	56	6	MP:0005463
MousePheno	abnormal cytokine secretion	MYO1G IL12RB2 HDAC6 NFATC2 IL25 TBX21 CD44 APBA3 IRF5 TRIM27 IL27RA	5.69e-05	668	56	11	MP:0003009
MousePheno	increased interleukin level	ACE2 IL12RB2 CD44 AKR1C1 AKR1C2 IL27RA	6.61e-05	174	56	6	MP:0014437
MousePheno	abnormal circulating interleukin level	ACE2 IL12RB2 HDAC6 CD44 APBA3 IRF5 IL27RA	1.05e-04	274	56	7	MP:0008588
MousePheno	abnormal interleukin secretion	IL12RB2 HDAC6 NFATC2 IL25 TBX21 CD44 APBA3 IRF5 IL27RA	1.07e-04	478	56	9	MP:0008568
MousePheno	decreased tumor necrosis factor secretion	MYO1G NFATC2 IL25 APBA3 IRF5	1.40e-04	125	56	5	MP:0008561
MousePheno	abnormal circulating interleukin-12 level	IL12RB2 APBA3 IL27RA	4.30e-04	37	56	3	MP:0008616
MousePheno	enhanced coordination	CD44 AKR1C1 AKR1C2	4.65e-04	38	56	3	MP:0003858
MousePheno	increased susceptibility to parasitic infection	IL25 TBX21 CD44 IL27RA	4.77e-04	91	56	4	MP:0005027
MousePheno	abnormal circulating cytokine level	ACE2 IL12RB2 HDAC6 CD44 APBA3 IRF5 IL27RA	5.11e-04	355	56	7	MP:0010210
Domain	-	IGSF10 IL12RB2 NFATC2 HLA-DOA MYPN ICAM3 IGSF9B MYBPHL USH2A NCR3LG1 PLXNB1 CDON IL27RA	1.30e-06	663	72	13	2.60.40.10
Domain	Ig-like_fold	IGSF10 IL12RB2 NFATC2 HLA-DOA MYPN ICAM3 IGSF9B MYBPHL USH2A NCR3LG1 PLXNB1 CDON IL27RA	2.61e-06	706	72	13	IPR013783
Domain	CXorf40	EOLA2 EOLA1	1.47e-05	2	72	2	IPR033615
Domain	fn3	IL12RB2 IGSF9B MYBPHL USH2A CDON IL27RA	3.78e-05	162	72	6	PF00041
Domain	ASCH_domain	EOLA2 EOLA1	4.39e-05	3	72	2	IPR007374
Domain	ASCH	EOLA2 EOLA1	4.39e-05	3	72	2	SM01022
Domain	FN3	IL12RB2 IGSF9B MYBPHL USH2A CDON IL27RA	7.91e-05	185	72	6	SM00060
Domain	OAS1_C	OAS2 OAS3	8.75e-05	4	72	2	PF10421
Domain	-	OAS2 OAS3	8.75e-05	4	72	2	1.10.1410.20
Domain	25A_SYNTH_1	OAS2 OAS3	8.75e-05	4	72	2	PS00832
Domain	25A_SYNTH_2	OAS2 OAS3	8.75e-05	4	72	2	PS00833
Domain	2-5-oligoadenylate_synth_CS	OAS2 OAS3	8.75e-05	4	72	2	IPR006117
Domain	25A_SYNTH_3	OAS2 OAS3	8.75e-05	4	72	2	PS50152
Domain	2-5-oligoAdlate_synth_1_dom2/C	OAS2 OAS3	8.75e-05	4	72	2	IPR018952
Domain	2-5A_synthase	OAS2 OAS3	8.75e-05	4	72	2	IPR026774
Domain	FN3	IL12RB2 IGSF9B MYBPHL USH2A CDON IL27RA	1.18e-04	199	72	6	PS50853
Domain	AMP-binding_CS	ACSL3 ACSL4 ACSM5	1.34e-04	26	72	3	IPR020845
Domain	2-5-oligoadenylate_synth_N	OAS2 OAS3	1.45e-04	5	72	2	IPR006116
Domain	FN3_dom	IL12RB2 IGSF9B MYBPHL USH2A CDON IL27RA	1.54e-04	209	72	6	IPR003961
Domain	AMP_BINDING	ACSL3 ACSL4 ACSM5	1.68e-04	28	72	3	PS00455
Domain	AMP-binding	ACSL3 ACSL4 ACSM5	2.07e-04	30	72	3	PF00501
Domain	AMP-dep_Synth/Lig	ACSL3 ACSL4 ACSM5	2.07e-04	30	72	3	IPR000873
Domain	HEMATOPO_REC_L_F2	IL12RB2 IL27RA	4.04e-04	8	72	2	PS01353
Domain	IG_LIKE	IGSF10 HLA-DOA MYPN ICAM3 IGSF9B MYBPHL NCR3LG1 CDON	5.90e-04	491	72	8	PS50835
Domain	ALDOKETO_REDUCTASE_1	AKR1C1 AKR1C2	6.46e-04	10	72	2	PS00798
Domain	Aldo/ket_reductase_CS	AKR1C1 AKR1C2	6.46e-04	10	72	2	IPR018170
Domain	Aldo/keto_reductase	AKR1C1 AKR1C2	6.46e-04	10	72	2	IPR020471
Domain	ALDOKETO_REDUCTASE_2	AKR1C1 AKR1C2	6.46e-04	10	72	2	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1C1 AKR1C2	6.46e-04	10	72	2	PS00063
Domain	Ig-like_dom	IGSF10 HLA-DOA MYPN ICAM3 IGSF9B MYBPHL NCR3LG1 CDON	6.91e-04	503	72	8	IPR007110
Domain	NTP_transf_2	OAS2 OAS3	7.88e-04	11	72	2	PF01909
Domain	Polymerase_NTP_transf_dom	OAS2 OAS3	7.88e-04	11	72	2	IPR002934
Domain	Ig_I-set	IGSF10 MYPN IGSF9B MYBPHL CDON	8.33e-04	190	72	5	IPR013098
Domain	I-set	IGSF10 MYPN IGSF9B MYBPHL CDON	8.33e-04	190	72	5	PF07679
Domain	IG	IGSF10 MYPN ICAM3 IGSF9B MYBPHL NCR3LG1 CDON	1.17e-03	421	72	7	SM00409
Domain	Ig_sub	IGSF10 MYPN ICAM3 IGSF9B MYBPHL NCR3LG1 CDON	1.17e-03	421	72	7	IPR003599
Domain	-	AKR1C1 AKR1C2	1.70e-03	16	72	2	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1C1 AKR1C2	1.92e-03	17	72	2	IPR023210
Domain	Aldo_ket_red	AKR1C1 AKR1C2	1.92e-03	17	72	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1C1 AKR1C2	1.92e-03	17	72	2	IPR001395
Domain	IGc2	IGSF10 MYPN IGSF9B MYBPHL CDON	2.13e-03	235	72	5	SM00408
Domain	Ig_sub2	IGSF10 MYPN IGSF9B MYBPHL CDON	2.13e-03	235	72	5	IPR003598
Domain	PUA-like_domain	EOLA2 EOLA1	2.40e-03	19	72	2	IPR015947
Domain	IPT	NFATC2 PLXNB1	4.83e-03	27	72	2	SM00429
Domain	TIG	NFATC2 PLXNB1	6.34e-03	31	72	2	PF01833
Domain	IPT	NFATC2 PLXNB1	6.75e-03	32	72	2	IPR002909
Pathway	WP_FERROPTOSIS	ACSL3 ACSL4 AKR1C1 AKR1C2	8.23e-05	64	51	4	M39768
Pathway	PID_IL27_PATHWAY	IL12RB2 TBX21 IL27RA	1.09e-04	26	51	3	M36
Pathway	WP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION	ACE2 OAS2 OAS3	1.87e-04	31	51	3	M39859
Pathway	REACTOME_FATTY_ACID_METABOLISM	ACSL3 ACSL4 AKR1C1 AKR1C2 GGT5	3.61e-04	170	51	5	MM15573
Pathway	REACTOME_INTERFERON_GAMMA_SIGNALING	CD44 OAS2 OAS3 IRF5	4.27e-04	98	51	4	M965
Pathway	WP_BENZOAPYRENE_METABOLISM	AKR1C1 AKR1C2	4.55e-04	9	51	2	M39344
Pathway	REACTOME_INTERLEUKIN_35_SIGNALLING	IL12RB2 IL27RA	4.55e-04	9	51	2	MM15580
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY	AKR1C1 AKR1C2	4.55e-04	9	51	2	M47817
Pathway	REACTOME_OAS_ANTIVIRAL_RESPONSE	OAS2 OAS3	4.55e-04	9	51	2	M27859
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL3 ACSL4	6.91e-04	11	51	2	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL3 ACSL4	6.91e-04	11	51	2	MM15035
Pathway	KEGG_MEDICUS_REFERENCE_BETA_OXIDATION_ACYL_COA_SYNTHESIS	ACSL3 ACSL4	6.91e-04	11	51	2	M47626
Pathway	KEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM	AKR1C1 AKR1C2	6.91e-04	11	51	2	M47812
Pathway	REACTOME_INTERLEUKIN_35_SIGNALLING	IL12RB2 IL27RA	8.28e-04	12	51	2	M27860
Pathway	REACTOME_DRUG_ADME	ACSM5 AKR1C1 AKR1C2 GGT5	8.88e-04	119	51	4	MM15692
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	AKR1C1 AKR1C2	9.76e-04	13	51	2	M17842
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL	AKR1C1 AKR1C2	9.76e-04	13	51	2	MM14747
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	1.14e-03	14	51	2	M39780
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	AKR1C1 AKR1C2	1.14e-03	14	51	2	M46449
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	AKR1C1 AKR1C2	1.14e-03	14	51	2	M27074
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	AKR1C1 AKR1C2	1.14e-03	14	51	2	M46453
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	1.14e-03	14	51	2	MM15840
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	AKR1C1 AKR1C2	1.14e-03	14	51	2	MM14748
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	1.31e-03	15	51	2	M39789
Pathway	REACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX	AKR1C1 AKR1C2	1.31e-03	15	51	2	MM14870
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	AKR1C1 AKR1C2 GGT5	1.38e-03	61	51	3	MM14861
Pathway	REACTOME_INTERLEUKIN_12_FAMILY_SIGNALING	IL12RB2 IL27RA	1.49e-03	16	51	2	MM15127
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	1.49e-03	16	51	2	MM15841
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACSL3 ACSL4	1.49e-03	16	51	2	MM15813
Pathway	WP_MITOCHONDRIAL_LONG_CHAIN_FATTY_ACID_BETAOXIDATION	ACSL3 ACSL4	1.69e-03	17	51	2	M39365
Pathway	WP_FATTY_ACID_TRANSPORTERS	ACSL3 ACSL4	1.89e-03	18	51	2	M42570
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	NFATC2 SZT2 CTC1 LMO7 CD44 IGSF9B B3GNT3 KDM4B RSKR	2.97e-06	552	75	9	10737800
Pubmed	Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.	IL12RB2 TBX21	4.59e-06	2	75	2	21307296
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	4.59e-06	2	75	2	8573067
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	4.59e-06	2	75	2	11514561
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	4.59e-06	2	75	2	15492289
Pubmed	ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.	HDAC6 ATP13A2	4.59e-06	2	75	2	25548531
Pubmed	Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.	ACSL3 ACSL4	4.59e-06	2	75	2	32286604
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	4.59e-06	2	75	2	8011662
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	4.59e-06	2	75	2	18654764
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	4.59e-06	2	75	2	21217827
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	4.59e-06	2	75	2	26934124
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	4.59e-06	2	75	2	8486699
Pubmed	Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.	ACSL3 ACSL4	4.59e-06	2	75	2	28193492
Pubmed	The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.	ACSL3 ACSL4	4.59e-06	2	75	2	29450800
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	1.37e-05	3	75	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	1.37e-05	3	75	2	31780644
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	1.37e-05	3	75	2	21232532
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	1.37e-05	3	75	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	1.37e-05	3	75	2	22064385
Pubmed	NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.	NFATC2 TBX21	1.37e-05	3	75	2	15684054
Pubmed	The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.	OAS2 OAS3	1.37e-05	3	75	2	9790745
Pubmed	Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?	OAS2 OAS3	1.37e-05	3	75	2	16014697
Pubmed	OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion.	OAS2 OAS3	1.37e-05	3	75	2	30822544
Pubmed	Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.	OAS2 OAS3	1.37e-05	3	75	2	27899133
Pubmed	Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.	OAS2 OAS3	1.37e-05	3	75	2	2440675
Pubmed	Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.	NFATC2 TBX21	1.37e-05	3	75	2	17082665
Pubmed	OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.	OAS2 OAS3	1.37e-05	3	75	2	35305973
Pubmed	An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12.	IL12RB2 TBX21	1.37e-05	3	75	2	26244629
Pubmed	Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19.	OAS2 OAS3	1.37e-05	3	75	2	33138195
Pubmed	Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.	OAS2 OAS3	1.37e-05	3	75	2	23337612
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	2.75e-05	4	75	2	20124700
Pubmed	Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.	NFATC2 TBX21	2.75e-05	4	75	2	23616576
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	2.75e-05	4	75	2	10500239
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	2.75e-05	4	75	2	16508162
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	2.75e-05	4	75	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.75e-05	4	75	2	14967952
Pubmed	Gene structure of the murine 2'-5'-oligoadenylate synthetase family.	OAS2 OAS3	2.75e-05	4	75	2	12222967
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	2.75e-05	4	75	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	2.75e-05	4	75	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	2.75e-05	4	75	2	31479646
Pubmed	T helper cell-specific regulation of inducible costimulator expression via distinct mechanisms mediated by T-bet and GATA-3.	NFATC2 TBX21	2.75e-05	4	75	2	17986443
Pubmed	ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion.	HDAC6 ATP13A2	2.75e-05	4	75	2	30538141
Pubmed	Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.	IL12RB2 TBX21	2.75e-05	4	75	2	21516110
Pubmed	IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD.	TBX21 IL27RA	2.75e-05	4	75	2	18375937
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.75e-05	4	75	2	15222881
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	2.75e-05	4	75	2	16191478
Pubmed	IL-27 limits IL-2 production during Th1 differentiation.	TBX21 IL27RA	2.75e-05	4	75	2	16365415
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	2.75e-05	4	75	2	15577209
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	2.75e-05	4	75	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	2.75e-05	4	75	2	17034817
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	2.75e-05	4	75	2	17629694
Pubmed	130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.	EOLA2 EOLA1	2.75e-05	4	75	2	8717057
Pubmed	GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet.	IL12RB2 TBX21	2.75e-05	4	75	2	12648458
Pubmed	Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.	IL12RB2 IL27RA	2.75e-05	4	75	2	28239679
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	2.75e-05	4	75	2	29764944
Pubmed	Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo.	CD44 GAB1	2.75e-05	4	75	2	17923692
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	2.75e-05	4	75	2	10526179
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	2.75e-05	4	75	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	2.75e-05	4	75	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	2.75e-05	4	75	2	28329705
Pubmed	Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.	OAS2 OAS3	2.75e-05	4	75	2	19923450
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	2.75e-05	4	75	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	2.75e-05	4	75	2	17272929
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	2.75e-05	4	75	2	19237748
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	2.75e-05	4	75	2	18667791
Pubmed	Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease.	OAS2 OAS3	2.75e-05	4	75	2	21050126
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	2.75e-05	4	75	2	28259989
Pubmed	Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection.	TBX21 IL27RA	2.75e-05	4	75	2	18178806
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	2.75e-05	4	75	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	2.75e-05	4	75	2	8274401
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	2.75e-05	4	75	2	16511129
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	2.75e-05	4	75	2	10803568
Pubmed	T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.	IL12RB2 TBX21	2.75e-05	4	75	2	12006974
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	2.75e-05	4	75	2	34590152
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	2.75e-05	4	75	2	7789999
Pubmed	Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.	ACE2 CD44 CDON	4.15e-05	31	75	3	36971701
Pubmed	Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.	AKR1C1 AKR1C2	4.57e-05	5	75	2	7737980
Pubmed	OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet.	IL12RB2 TBX21	4.57e-05	5	75	2	17548606
Pubmed	The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.	OAS2 OAS3	4.57e-05	5	75	2	21142819
Pubmed	Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.	TBX21 IL27RA	4.57e-05	5	75	2	16906166
Pubmed	Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.	AKR1C1 AKR1C2	4.57e-05	5	75	2	21851338
Pubmed	Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.	AKR1C1 AKR1C2	4.57e-05	5	75	2	17872381
Pubmed	Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.	OAS2 OAS3	4.57e-05	5	75	2	12396720
Pubmed	Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.	CD44 GAB1	4.57e-05	5	75	2	12748184
Pubmed	Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.	AKR1C1 AKR1C2	4.57e-05	5	75	2	17064890
Pubmed	Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.	AKR1C1 AKR1C2	4.57e-05	5	75	2	10672042
Pubmed	Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.	ACSL3 ACSL4	4.57e-05	5	75	2	15292367
Pubmed	T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells.	TBX21 IL27RA	4.57e-05	5	75	2	33603753
Pubmed	Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.	TBX21 IL27RA	4.57e-05	5	75	2	17994023
Pubmed	IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.	IL12RB2 TBX21	4.57e-05	5	75	2	31775046
Pubmed	Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.	AKR1C1 AKR1C2	4.57e-05	5	75	2	38788959
Pubmed	Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.	AKR1C1 AKR1C2	4.57e-05	5	75	2	15212687
Pubmed	Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.	AKR1C1 AKR1C2	4.57e-05	5	75	2	16984997
Pubmed	The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.	ACSL3 ACSL4	4.57e-05	5	75	2	22633490
Pubmed	Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.	AKR1C1 AKR1C2	4.57e-05	5	75	2	18003893
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	ACSL3 MAP7D1 HDAC6 SZT2 MTHFD1L SPTLC1 TRIM27 WDR62	4.91e-05	606	75	8	36538041
Pubmed	The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.	AKR1C1 AKR1C2	6.84e-05	6	75	2	29107092
Pubmed	Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.	AKR1C1 AKR1C2	6.84e-05	6	75	2	19273550
Pubmed	Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.	OAS2 OAS3	6.84e-05	6	75	2	14559211
Pubmed	Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.	AKR1C1 AKR1C2	6.84e-05	6	75	2	15860270
Cytoband	10p15-p14	AKR1C1 AKR1C2	3.93e-05	6	75	2	10p15-p14
Cytoband	12q24.2	OAS2 OAS3	3.11e-04	16	75	2	12q24.2
GeneFamily	Fibronectin type III domain containing	IL12RB2 IGSF9B MYBPHL USH2A CDON IL27RA	3.48e-06	160	47	6	555
GeneFamily	Acyl-CoA synthetase family	ACSL3 ACSL4 ACSM5	4.10e-05	26	47	3	40
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF10 MYPN IGSF9B MYBPHL CDON	5.97e-05	161	47	5	593
GeneFamily	Aldo-keto reductases	AKR1C1 AKR1C2	6.80e-04	15	47	2	399
GeneFamily	Zinc fingers CCCH-type	ZC3H4 ZC3H6	3.73e-03	35	47	2	73
GeneFamily	C1-set domain containing	HLA-DOA NCR3LG1	5.33e-03	42	47	2	591
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL12RB2 IL27RA	5.33e-03	42	47	2	602
GeneFamily	PDZ domain containing	LMO7 APBA3 FRMPD3	7.21e-03	152	47	3	1220
GeneFamily	Immunoglobulin like domain containing	ICAM3 IGSF9B CDON	1.38e-02	193	47	3	594
Coexpression	HE_LIM_SUN_FETAL_LUNG_C5_CD5_POS_CCL22_NEG_MATURE_B_CELL	CD44 TMC8 IRF5 DENND1C PLK3 IL27RA	6.70e-06	160	75	6	M45779
ToppCell	Adult-Immune-natural_killer_cell-D231\|Adult / Lineage, Cell type, age group and donor	IL12RB2 NFATC2 ICAM3 TBX21 TMC8 DENND1C	6.44e-07	182	75	6	dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G IL12RB2 NFATC2 TBX21 TMC8 DENND1C	8.28e-07	190	75	6	4a75457652d85874d5c6a41648f8003572008b15
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G IL12RB2 NFATC2 TBX21 TMC8 DENND1C	8.28e-07	190	75	6	cda6173634531240e0bab8766231a150ff8d0129
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8 DENND1C	8.54e-07	191	75	6	96a7179a845d3daa046ed71fa45c51255f130a7f
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-NK_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G IL12RB2 ICAM3 TBX21 CD44 IL27RA	9.08e-07	193	75	6	044fba87c4d10f4943a9f57315920280a4d097e7
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Activated_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL12RB2 ICAM3 TBX21 CD44 TMC8 IL27RA	9.35e-07	194	75	6	e3705346755cbf65fc276d4d4fbee936ed6bb7bf
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ICAM3 TBX21 CD44 TMC8 DENND1C IL27RA	9.35e-07	194	75	6	6385cf2a1529d2e225e407c33da959fccaaca3a4
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C IL27RA	9.35e-07	194	75	6	23174bfd1159619b2660f9bc07c99ba771f6a4e7
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-Intermediate_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C IL27RA	9.35e-07	194	75	6	54c809ed134ed828f3653603cf821cc303240f36
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-CD16+_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYO1G NFATC2 TBX21 TMC8 DENND1C IL27RA	9.64e-07	195	75	6	eadc2f8dd16d2b76c59b85f72905bd4b1545b560
ToppCell	wk_20-22-Hematologic_Lymphocytic\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MYO1G ICAM3 TBX21 TMC8 DENND1C IL27RA	1.02e-06	197	75	6	77107345c766451302e21f7cbd45316f4131a0e8
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-SELL+_CD4_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ICAM3 CD44 TMC8 DENND1C PLK3 IL27RA	1.08e-06	199	75	6	b01328a80db5bb088c44564cea0f6729b1a9805b
ToppCell	5'-GW_trimst-2-LymphNode\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 TMC8 DENND1C IL27RA	1.08e-06	199	75	6	4a9ca133125dc25a06e7b1cfea15ecffa449c20e
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 TMC8 DENND1C IL27RA	1.08e-06	199	75	6	da20998253ad08a4a127a98b991b26237edb61a2
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G NFATC2 ICAM3 TBX21 TMC8 DENND1C	1.12e-06	200	75	6	6b34f2b85d4f83c1270ee151f602cba6f42042ba
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G NFATC2 ICAM3 TBX21 TMC8 DENND1C	1.12e-06	200	75	6	b2c5618aa1ac19423996336795dadb39ea57cda7
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBX21 TMC8 DENND1C STKLD1 TRIM27	6.88e-06	157	75	5	a633fb8e7a009490c6002bf272eceaf317f27af6
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-mature_NK_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G IL12RB2 TBX21 DENND1C IL27RA	8.50e-06	164	75	5	22f37c39fdce2cf6dc72c6db619537d4b0234839
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G IL12RB2 TBX21 DENND1C IL27RA	9.02e-06	166	75	5	d80c2522cf314d56730d60f160b1247933443378
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G IL12RB2 TBX21 DENND1C IL27RA	9.02e-06	166	75	5	f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-mature_NK_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G TBX21 CD44 DENND1C IL27RA	1.04e-05	171	75	5	562fc8a422615dbbece67ea49740f0c09bdb9ae3
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G TBX21 CD44 DENND1C IL27RA	1.20e-05	176	75	5	27c5ddd67de52101360ef7de8fcfa041066d97db
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ICAM3 CD44 TMC8 DENND1C IL27RA	1.20e-05	176	75	5	88247142c6482f3b4fa845d64e6189c690a5ee52
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G ICAM3 TBX21 CD44 TMC8	1.30e-05	179	75	5	874a9afa91774221c9c1775aa4968ba0aea7b554
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 TBX21 CD44 TMC8	1.30e-05	179	75	5	e717c0079b788a3703c0a450922bd5a2bdc322a0
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	COL15A1 AEBP1 MTHFD1L WFDC1 IGSF9B	1.33e-05	180	75	5	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL15A1 NFATC2 MTHFD1L AKR1C1 AKR1C2	1.37e-05	181	75	5	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 TMC8 IL27RA	1.41e-05	182	75	5	7dd435e456da1470d19d3db307ae4909c25d2f0d
ToppCell	wk_08-11-Hematologic_Lymphocytic-NK-Cycling_NK\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 ICAM3 TBX21 TMC8	1.44e-05	183	75	5	19652ca16989cb0be7d444cb5bf209b32d163bdb
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-NKT2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IL12RB2 ICAM3 CD44 TMC8 IL27RA	1.52e-05	185	75	5	2d95713deaa05fb3372f4337ef156027e4d8ec8a
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C	1.60e-05	187	75	5	9d298f43ae81d72091b31aaa6df41046d4aa31c5
ToppCell	11.5-Airway-Immune-Hematopoietic,_Natural_Killer_Cell\|Airway / Age, Tissue, Lineage and Cell class	MYO1G IL12RB2 TBX21 TMC8 DENND1C	1.60e-05	187	75	5	bebb56d31a1df678d85a29931a2ec585549ac122
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_lymphoid_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C	1.73e-05	190	75	5	bee6a438e217b2abd57aef2a80a9fe14a298d223
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8	1.73e-05	190	75	5	ba61f04fd38efae01f721ba616252d1372ff1002
ToppCell	COVID-19-kidney-NK\|kidney / Disease (COVID-19 only), tissue and cell type	MYO1G IL12RB2 NFATC2 TBX21 TMC8	1.73e-05	190	75	5	e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8	1.73e-05	190	75	5	b772a5d281fe016f259ddda80d6f33d949dcac2b
ToppCell	wk_08-11-Hematologic_Lymphocytic-NK\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C	1.73e-05	190	75	5	86b0d142b7d1a3b35580edd104f947106be2c9c6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8	1.73e-05	190	75	5	5a37568000dfc33fcbb59b578c1963fb7cf872ec
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-Treg\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYO1G ICAM3 TMC8 DENND1C IL27RA	1.73e-05	190	75	5	fe6fecdf2123f3a4fb20e7535472d562b1a74fb4
ToppCell	Adult-Immune-natural_killer_cell\|Adult / Lineage, Cell type, age group and donor	IL12RB2 NFATC2 TBX21 TMC8 DENND1C	1.77e-05	191	75	5	758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IL12RB2 NFATC2 TBX21 TMC8 DENND1C	1.77e-05	191	75	5	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NFATC2 ICAM3 TBX21 TMC8 DENND1C	1.82e-05	192	75	5	8f0d37d204958aaf77214a6c75bef2bf5498f11c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8	1.82e-05	192	75	5	b498618505bb1b7ff9574d06875dd272c11bac39
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NFATC2 ICAM3 TBX21 TMC8 DENND1C	1.82e-05	192	75	5	8f7e0ddf3855199b0aa63b633dc2948f03607933
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Treg\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 TMC8 IL27RA	1.87e-05	193	75	5	f3eb295a019de29f484964f00ea436860af249a5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G NFATC2 TBX21 CD44 TMC8	1.87e-05	193	75	5	12f1333f11e6c262954ad7912d8fd2962ab06d25
ToppCell	COVID-19-lung-NK/NKT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYO1G IL12RB2 NFATC2 TBX21 TMC8	1.87e-05	193	75	5	c24b44fcc92fff42ebba6f1aff91c7aaea179e56
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-Cycling_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 CDCA5 WDR62	1.91e-05	194	75	5	af08047e5728ee8198d2686af6a774f2acfa58ba
ToppCell	COVID-19-lung-NK_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYO1G NFATC2 TBX21 TMC8 DENND1C	1.91e-05	194	75	5	4c92f18e0a34fb50630d4b260eaf179202508b6d
ToppCell	RA\|World / Chamber and Cluster_Paper	ACSL4 NFATC2 MTHFD1L AKR1C1 AKR1C2	1.91e-05	194	75	5	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	PCW_13-14-Immune_Lymphocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MYO1G IL12RB2 TBX21 TMC8 DENND1C	1.91e-05	194	75	5	36678999d0c1c5b0aab206fec7a8c36a0f43c56a
ToppCell	COVID-19-kidney-Proliferating_T_cell\|kidney / Disease (COVID-19 only), tissue and cell type	MYO1G NFATC2 TMC8 CDCA5 WDR62	1.96e-05	195	75	5	7e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 DENND1C IL27RA	1.96e-05	195	75	5	d81ac3a8f2b7b767bdd03641ab6329917273cd75
ToppCell	wk_08-11-Hematologic-Myeloid-Myelocyte-like\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ICAM3 TMC8 IRF5 AKR1C2 GAB1	2.01e-05	196	75	5	4b88c96b737a747422674ad99c073b28e6febc7c
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-Intermediate_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IL12RB2 ICAM3 TBX21 TMC8 IL27RA	2.01e-05	196	75	5	a2f938022a080202bce5bb157d13b86b69054468
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 CD44 TMC8 DENND1C	2.01e-05	196	75	5	ab6022041c33617bca3ed0c62f19673cd2750da9
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G ICAM3 TBX21 CD44 TMC8	2.01e-05	196	75	5	609959609ab1870c562cefca0fd49e0d701d1e5b
ToppCell	kidney_cells-Adult_normal_reference-Immune-Lymphocytic_T/NK\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1G ICAM3 TBX21 CD44 TMC8	2.06e-05	197	75	5	44f9ea5c313fabb6e6a46c7b39f3cb924b8af1f4
ToppCell	18-Airway-Immune-Hematopoietic,_T_Cells\|Airway / Age, Tissue, Lineage and Cell class	MYO1G ICAM3 CD44 TMC8 IL27RA	2.06e-05	197	75	5	ba40a8b6871c8a0166195c03e7e3deae5834ec56
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	AEBP1 HLA-DOA MTHFD1L EOLA1 ATP13A2	2.06e-05	197	75	5	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	CD8+_Memory_T_cell-CV-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MAP7D1 NFATC2 AEBP1 TBX21 PLK3	2.06e-05	197	75	5	9fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCell	CV-Moderate-3\|CV / Virus stimulation, Condition and Cluster	MAP7D1 NFATC2 AEBP1 TBX21 PLK3	2.06e-05	197	75	5	7031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 AEBP1 MTHFD1L WFDC1 IGSF9B	2.11e-05	198	75	5	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-CD4_T\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ICAM3 CD44 TMC8 DENND1C IL27RA	2.11e-05	198	75	5	51af4e53a7a4aa7fb84380e1f10229725a178a73
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 COL15A1 NFATC2 AEBP1 WFDC1	2.11e-05	198	75	5	524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	COL15A1 NFATC2 AEBP1 WFDC1 CDON	2.11e-05	198	75	5	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	BAL-Severe-Epithelial-Epithelial-Basal/Club\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LMO7 LRATD1 B3GNT3 AKR1C1 AKR1C2	2.16e-05	199	75	5	d04062d86643e5712cc2f519f4f36e643d404a16
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ICAM3 CD44 TMC8 DENND1C IL27RA	2.16e-05	199	75	5	c9e1ac9f0fba23250a5df4052559d18d16df4521
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-gdT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G ICAM3 TBX21 TMC8 FRMPD3	2.16e-05	199	75	5	74d53ad732dd29ad84d81f9c72f586f6c7bc5c57
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G IL12RB2 ICAM3 TBX21 TMC8	2.16e-05	199	75	5	713fab2e946b300d21215aff1553785e8857ce65
ToppCell	BAL-Severe-Epithelial-Epithelial-Basal/Club-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LMO7 LRATD1 B3GNT3 AKR1C1 AKR1C2	2.16e-05	199	75	5	a3f83fe5c3c557cd3ef8f5632f7fba5cf1859937
ToppCell	15-Trachea-Immune-Hematopoietic,_T_Cells\|Trachea / Age, Tissue, Lineage and Cell class	MYO1G ICAM3 CD44 TMC8 IL27RA	2.16e-05	199	75	5	d5dcf7b4f58a075a7f729165556f7666e6b4c104
ToppCell	BAL-Severe-Epithelial-Epithelial-Basal/Club\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	LMO7 LRATD1 B3GNT3 AKR1C1 AKR1C2	2.16e-05	199	75	5	644197ff7e3299587881dd678836262e670ed4a8
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G ICAM3 TBX21 CD44 TMC8	2.16e-05	199	75	5	38eb4495dd4f2a52941d9228f268338a526ec26c
ToppCell	cellseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD8_T\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1G ICAM3 TBX21 TMC8 DENND1C	2.16e-05	199	75	5	f96a6b95329ec6642b3a528c9e346ab3e1733c25
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ICAM3 CD44 TMC8 DENND1C IL27RA	2.16e-05	199	75	5	45d0d275ffb4183e3e71f4701e121ef9853ebd10
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G IL12RB2 ICAM3 TBX21 TMC8	2.16e-05	199	75	5	ffd5b4d58d81b76e01d87016209f16879d81c592
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 AEBP1 MTHFD1L WFDC1 IGSF9B	2.16e-05	199	75	5	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Severe-Lymphoid\|Severe / Condition, Lineage, Cell class and cell subclass	IL12RB2 NFATC2 ICAM3 TBX21 CDCA5	2.16e-05	199	75	5	928e346b0f31d991ebab12fefb4eb9f4249e601d
ToppCell	Severe_COVID-19-Epithelial-Basal/Club\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	LMO7 LRATD1 B3GNT3 AKR1C1 AKR1C2	2.16e-05	199	75	5	2a0aebcfadff4e2dfc8244ad8a87c338ecccacfd
ToppCell	BAL-Severe-Epithelial-Epithelial-Basal/Club-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LMO7 LRATD1 B3GNT3 AKR1C1 AKR1C2	2.16e-05	199	75	5	fd364f43859b2e7a3e91ce6a1c430cc42ad26a49
ToppCell	21-Trachea-Immune\|Trachea / Age, Tissue, Lineage and Cell class	MYO1G ICAM3 CD44 TMC8 IL27RA	2.21e-05	200	75	5	fd76b94655b3e29fb8ddd8a74a20a5be97f42337
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-T-T_CD8-CD8_CTL\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MYO1G ICAM3 TBX21 TMC8 DENND1C	2.21e-05	200	75	5	dc719c7f0ffee0db4f56f1991e47974dc7bef11b
ToppCell	Biopsy_IPF-Immune-T_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	IL12RB2 NFATC2 ICAM3 TBX21 TMC8	2.21e-05	200	75	5	368c7334d211054f1e914a1be4027aa75e2df66c
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IL12RB2 NFATC2 ICAM3 TBX21 TMC8	2.21e-05	200	75	5	b4d956067eb292cf2855c674d1eb05a5f2d988f7
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IL12RB2 NFATC2 ICAM3 TBX21 TMC8	2.21e-05	200	75	5	d1cfc4ef6ae75c486427e393d98b84a2a7ec67fe
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	IL12RB2 NFATC2 TBX21 OAS2 OAS3	2.21e-05	200	75	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	15-Trachea-Immune\|Trachea / Age, Tissue, Lineage and Cell class	MYO1G ICAM3 CD44 TMC8 IL27RA	2.21e-05	200	75	5	8f1c6405de46907097e53e68e43883f21ea4f354
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IL12RB2 NFATC2 ICAM3 TBX21 TMC8	2.21e-05	200	75	5	c09bb5c994f098d86e873bd3f1d911b02563e6e2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYPN B3GNT3 AKR1C1 AKR1C2	5.39e-05	122	75	4	a7df7c9865364574833b79781281f156b9268ab1
ToppCell	E18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ACE2 ACSM5 WFDC1 IL27RA	1.17e-04	149	75	4	82edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCell	E18.5-samps-Epithelial-Epithelial-non_alveolar\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ACE2 ACSM5 WFDC1 IL27RA	1.17e-04	149	75	4	14a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCell	P15-Hematopoietic-Immune\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYO1G HLA-DOA IRF5 DENND1C	1.23e-04	151	75	4	a54045cac65a66197e3ad2b002fa6c511102834a
ToppCell	P15-Hematopoietic-Immune-immune_cell_unspecified\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYO1G HLA-DOA IRF5 DENND1C	1.23e-04	151	75	4	6b905d309f2a9b8828399b36f4942aec8696bee6
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO1G KCNH6 HLA-DOA TBX21	1.36e-04	155	75	4	efe69145910c5e049d0ed30699c26ef963e0a285
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO1G KCNH6 IL12RB2 TBX21	1.36e-04	155	75	4	d8e9f355ce933f6383c3d1e35ff55235a95c7fcd
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DIS3L2 NFATC2 IRF5 STKLD1	1.40e-04	156	75	4	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IL12RB2 ICAM3 TMC8 WDR62	1.50e-04	159	75	4	048b6a97568242c8846034277680632e5de75840
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G TBX21 OAS3 IL27RA	1.54e-04	160	75	4	9e238e7cb31070a5b9da73b4bfddde54b969b0fd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G TBX21 OAS3 IL27RA	1.54e-04	160	75	4	3a5a7984d9ffcb0fbada02b95ffd7aca091acf30
Drug	(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	AKR1C1 AKR1C2	1.07e-05	2	75	2	DB07768
Drug	3-methylcatechol	HDAC6 OAS2 OAS3 TRIM27 GAB1	1.81e-05	98	75	5	CID000000340
Drug	cyclopentanone	AKR1C1 AKR1C2	3.21e-05	3	75	2	ctd:C007201
Drug	5-dihydrodeoxycorticosterone	AKR1C1 AKR1C2	3.21e-05	3	75	2	ctd:C454687
Drug	4-benzoylbenzoic acid	AKR1C1 AKR1C2	3.21e-05	3	75	2	ctd:C058818
Drug	cyclopentanol	AKR1C1 AKR1C2	3.21e-05	3	75	2	ctd:C016327
Drug	dichloro(4-cymene)ruthenium(II)	AKR1C1 AKR1C2	3.21e-05	3	75	2	ctd:C530610
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	HDAC6 CD44 PLK3 PLXNB1 WDR62 IL27RA	4.90e-05	198	75	6	6031_DN
Drug	Iobenguane sulfate; Down 200; 10.8uM; MCF7; HT_HG-U133A	ACSL4 CD44 OAS3 WDR62 CDON IL27RA	5.04e-05	199	75	6	6002_DN
Drug	rapamycin, Streptomyces hygroscepicus; Down 200; 0.1uM; MCF7; HT_HG-U133A	ACSL4 CEP85 SPTLC1 CD44 OAS2 OAS3	5.19e-05	200	75	6	5927_DN
Drug	ApApA(Sp)A	OAS2 OAS3	6.40e-05	4	75	2	CID000501019
Drug	tetrahydrodeoxycorticosterone	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:C009413
Drug	ApA(Sp)A	OAS2 OAS3	6.40e-05	4	75	2	CID000501015
Drug	ApA(Sp)ApA	OAS2 OAS3	6.40e-05	4	75	2	CID000501017
Drug	A(Sp)ApA	OAS2 OAS3	6.40e-05	4	75	2	CID000501013
Drug	Pregnanes	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:D011278
Drug	tetralol	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:C019106
Drug	gliquidone	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:C010969
Drug	3',3'',5',5''-tetrabromophenolphthalein	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:C018156
Drug	adenosine N'-oxide	OAS2 OAS3	6.40e-05	4	75	2	CID000459896
Drug	poly(I,8-azidoI).poly(C	OAS2 OAS3	6.40e-05	4	75	2	CID003081572
Drug	cloxazolam	AKR1C1 AKR1C2	6.40e-05	4	75	2	ctd:C005522
Drug	imiquimod	IL25 TBX21 TMC8 OAS2 OAS3	7.57e-05	132	75	5	CID000057469
Drug	Hydroxysteroids	AKR1C1 AKR1C2	1.06e-04	5	75	2	ctd:D006914
Drug	NSC86000	AKR1C1 AKR1C2	1.06e-04	5	75	2	CID000257630
Drug	cresolphthalein	AKR1C1 AKR1C2	1.06e-04	5	75	2	ctd:C010092
Disease	non-syndromic X-linked intellectual disability 63 (implicated_via_orthology)	ACSL3 ACSL4	6.04e-06	2	73	2	DOID:0112050 (implicated_via_orthology)
Disease	systemic lupus erythematosus, COVID-19	IL12RB2 HLA-DOA OAS3 IRF5	1.32e-05	58	73	4	MONDO_0007915, MONDO_0100096
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	1.81e-05	3	73	2	C0027661
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	6.01e-05	5	73	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	6.01e-05	5	73	2	C0033804
Disease	Hermaphroditism	AKR1C1 AKR1C2	6.01e-05	5	73	2	C0019269
Disease	Intersex Conditions	AKR1C1 AKR1C2	6.01e-05	5	73	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	6.01e-05	5	73	2	C2930619
Disease	Sjogren-Larsson syndrome (implicated_via_orthology)	ACSL3 ACSL4	9.00e-05	6	73	2	DOID:14501 (implicated_via_orthology)
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	1.26e-04	7	73	2	C0036875
Disease	biliary liver cirrhosis	IL12RB2 EXOC3L4 IRF5	1.79e-04	44	73	3	EFO_0004267
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	ACSL3 ACSL4	2.15e-04	9	73	2	DOID:0050776 (implicated_via_orthology)
Disease	melanoma	HDAC6 RPP38 NPAP1 WFDC1 KDM4B	3.80e-04	248	73	5	C0025202
Disease	Sclerocystic Ovaries	LRATD1 AKR1C1 AKR1C2 GAB1	4.56e-04	144	73	4	C1136382
Disease	Polycystic Ovary Syndrome	LRATD1 AKR1C1 AKR1C2 GAB1	4.56e-04	144	73	4	C0032460
Disease	response to methotrexate	AKR1C1 AKR1C2	7.08e-04	16	73	2	GO_0031427
Disease	a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement	STKLD1 PRDM15	8.02e-04	17	73	2	EFO_0008011
Disease	alpha-2-macroglobulin receptor-associated protein measurement	HLA-DOA TRIM27	1.61e-03	24	73	2	EFO_0008021

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLPDTPGPEPELWLQ	URB2	586	Q14146
IAIVLGPNLLWPPEK	BARGIN	431	Q6ZT62
EIPIKVRLSPEPWTP	ACSL4	666	O60488
LPAEPLPPLLAPDVW	EXOC3L4	361	Q17RC7
LTVISNPRWLLEPIP	EOLA1	121	Q8TE69
LTVISNPRWLLEPIP	EOLA2	121	Q96DE9
ELPSILPEIWPKTPS	CDCA5	36	Q96FF9
PLPPILPDLHLEAWP	AMELY	181	Q99218
LWDAPVPVFPLTISP	CTC1	181	Q2NKJ3
PILAPSETLEWPLPP	AEBP1	171	Q8IUX7
PPVEPPASALELKVW	C2orf27A	71	P0DPF5
SPEPWLETVPLVTPE	APBA3	171	O96018
PAPLPVPQKIVATWE	ACSM5	26	Q6NUN0
IWGDPKPSPLTEPLI	DENND1C	666	Q8IV53
VLECLPQGLPWTIPP	DIS3L2	351	Q8IYB7
SPKPEEIPLTWIQPG	MTHFD1L	271	Q6UB35
ITLLPAHPWETQPVP	ISX	201	Q2M1V0
ESILLVPPTWPKPLV	NFATC2	366	Q13469
PAPLEIKPLPEWEEL	GAB1	531	Q13480
AVPDAPILPVSPIWE	NCR3LG1	416	Q68D85
LAEEPQPPLPDVLVW	FER1L4	651	A9Z1Z3
RLLIDWPTPEDPEPL	IL12RB2	691	Q99665
LWPPLASPLHPLEVQ	KCNH6	941	Q9H252
NPQKLWEDIPELPPI	KIF27	1291	Q86VH2
EVFLSVPDLPPLWPG	PLXNB1	551	O43157
WTLLEPELKTIPLTP	IL27RA	176	Q6UWB1
EEALWLPSPLEPPVL	KDM4B	476	O94953
PAPVLVEKPLPEWPV	RSKR	71	Q96LW2
VEKPLPEWPVPQFIN	RSKR	76	Q96LW2
PEPWTLPPEIQAKFL	LMO7	596	Q8WWI1
LELLWLQPAPEPPAP	LRATD1	126	Q96KN4
EDVKWPPTLQPPTLR	IRF5	161	Q13568
NELPAPSWNVLPAPL	OAS2	326	P29728
LPERVELAPLPPWQP	ICAM3	116	P32942
QLERELAEQPWPPLP	ATP13A2	1161	Q9NQ11
VDGNPPPEIIWILPN	IGSF10	2361	Q6WRI0
LRHWELQVPIPPPDA	HLA-DOA	201	P06340
PIRTPQIPEWLIILA	CD44	641	P16070
WGLEPFLPPSLLQVI	FRMPD3	336	Q5JV73
IVSWNALILPPVPEG	CDON	1246	Q4KMG0
PSLPILEPAQWISIL	CEP85	316	Q6P2H3
PQDPLPWPALATTLE	GGT5	211	P36269
LGPPNQPPVSIWLIV	ACE2	731	Q9BYF1
VQEQPPAIPEALAWP	B3GNT3	36	Q9Y2A9
PQLLPPIEEHPKIWL	MYBPHL	41	A2RUH7
PIPQEPQWSLPSKEL	MAP7D1	766	Q3KQU3
LLRWSTVPVPPLEPA	IL25	51	Q9H293
WSPPPIEIRLISPLA	AHCTF1	2211	Q8WYP5
PPVLPILTWPVLQSR	HDAC6	466	Q9UBN7
EPEPRLWVVPGALPQ	GPR15L	66	Q6UWK7
LPLPTVAPERWITPA	COL15A1	536	P39059
IPEKISIPWIPEPQV	CFAP47	2251	Q6ZTR5
WEVLEEAPPPVFPLR	IRGQ	421	Q8WZA9
PRPVILDPADPTWDL	OAS3	291	Q9Y6K5
LSVLPPGWQPDEPVV	SZT2	61	Q5T011
VAWIPPGILIPEIPV	USH2A	3791	O75445
IRIPEPWITPPDLQE	TRIM27	261	P14373
IIPRVPSLSVPWLQD	RPP38	196	P78345
LVLLPPVEQPEPTTW	RGP1	336	Q92546
PLTWRAVPQTDVLPP	PRDM15	1466	P57071
LPLPPSLPLLWDRGE	NPAP1	336	Q9NZP6
IEEWQPEPLVPPVPK	SPTLC1	61	O15269
PWVDPNSPVLLEDPV	AKR1C1	226	Q04828
PWVDPNSPVLLEDPV	AKR1C2	226	P52895
IPVKIRLSPEPWTPE	ACSL3	676	O95573
NPAPLAQPEPLVWVS	PLK3	451	Q9H4B4
EAVPPPPVLDWLVQP	WFDC1	106	Q9HC57
ITILPAQEWKPPLPA	TXNDC16	731	Q9P2K2
PWQVVPELVALGLPP	TMC8	571	Q8IU68
HIVWAPEDLLPVPLP	ZC3H6	876	P61129
KPTDPVDWPPLVLGL	WASHC5	1066	Q12768
EPLPQIPNLPFWVKE	SPATS1	246	Q496A3
LSLPVPPGPSWLLVD	IGSF9B	556	Q9UPX0
PADQLGLPWPPELVE	STKLD1	356	Q8NE28
TVLWNPEDLIPLPIP	ZC3H4	976	Q9UPT8
WVPVEALPPSPLELS	WDR62	1396	O43379
PLQLQPTPPLQLRWE	nan	256	A8MUA0
QGPPLVWTEIAPIRP	TBX21	471	Q9UL17
DLVWPLPPAVLQPFQ	MYO1G	771	B0I1T2
PPELTWLLNGQPVLP	MYPN	1101	Q86TC9