Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H2B deubiquitinase activity

USP3 USP22

5.71e-064202GO:0140936
GeneOntologyMolecularFunctionhistone H2A deubiquitinase activity

USP3 USP22

1.43e-056202GO:0140950
GeneOntologyMolecularFunctionhistone deubiquitinase activity

USP3 USP22

2.66e-058202GO:0140934
GeneOntologyMolecularFunctionRNA 7-methylguanosine cap binding

CYFIP2 CYFIP1

8.61e-0514202GO:0000340
GeneOntologyMolecularFunctionRNA cap binding

CYFIP2 CYFIP1

1.98e-0421202GO:0000339
GeneOntologyMolecularFunctionGTPase binding

CYFIP2 CYFIP1 HSP90AA1

5.28e-03360203GO:0051020
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP3 USP22

5.74e-03114202GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP3 USP22

6.76e-03124202GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP3 USP22

8.19e-03137202GO:0019783
GeneOntologyBiologicalProcessregulation of protein polymerization

HAUS6 CYFIP2 CYFIP1 HSP90AA1 OCLN

2.97e-06231215GO:0032271
GeneOntologyBiologicalProcesspositive regulation of lamellipodium assembly

CYFIP1 HSP90AA1 OCLN

4.43e-0632213GO:0010592
GeneOntologyBiologicalProcessregulation of protein-containing complex assembly

HAUS6 CYFIP2 CYFIP1 HSP90AA1 MPP7 OCLN

6.90e-06489216GO:0043254
GeneOntologyBiologicalProcesspositive regulation of lamellipodium organization

CYFIP1 HSP90AA1 OCLN

8.77e-0640213GO:1902745
GeneOntologyBiologicalProcessregulation of lamellipodium assembly

CYFIP1 HSP90AA1 OCLN

1.26e-0545213GO:0010591
GeneOntologyBiologicalProcessprotein polymerization

HAUS6 CYFIP2 CYFIP1 HSP90AA1 OCLN

1.78e-05334215GO:0051258
GeneOntologyBiologicalProcessregulation of lamellipodium organization

CYFIP1 HSP90AA1 OCLN

2.57e-0557213GO:1902743
GeneOntologyBiologicalProcesspositive regulation of neurotrophin TRK receptor signaling pathway

CYFIP2 CYFIP1

2.75e-058212GO:0051388
GeneOntologyBiologicalProcesslamellipodium assembly

CYFIP1 HSP90AA1 OCLN

6.84e-0579213GO:0030032
GeneOntologyBiologicalProcessregulation of neurotrophin TRK receptor signaling pathway

CYFIP2 CYFIP1

1.33e-0417212GO:0051386
GeneOntologyBiologicalProcesslamellipodium organization

CYFIP1 HSP90AA1 OCLN

1.34e-0499213GO:0097581
GeneOntologyBiologicalProcesspositive regulation of plasma membrane bounded cell projection assembly

CYFIP1 HSP90AA1 OCLN

2.54e-04123213GO:0120034
GeneOntologyBiologicalProcessneurotrophin TRK receptor signaling pathway

CYFIP2 CYFIP1

5.43e-0434212GO:0048011
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

HAUS6 CYFIP2 CYFIP1 OCLN

9.01e-04438214GO:1902903
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

HAUS6 CYFIP2 CYFIP1 HSP90AA1 MPP7 OCLN

9.29e-041189216GO:0044087
GeneOntologyBiologicalProcessdendrite extension

CYFIP2 CYFIP1

9.95e-0446212GO:0097484
GeneOntologyBiologicalProcessneurotrophin signaling pathway

CYFIP2 CYFIP1

1.04e-0347212GO:0038179
GeneOntologyCellularComponentdendritic growth cone

CYFIP1 HSP90AA1

5.71e-0512202GO:0044294
GeneOntologyCellularComponentSCAR complex

CYFIP2 CYFIP1

5.71e-0512202GO:0031209
GeneOntologyCellularComponentlateral plasma membrane

ABCC1 MPP7 OCLN

8.34e-0590203GO:0016328
GeneOntologyCellularComponentdendrite terminus

CYFIP1 HSP90AA1

1.64e-0420202GO:0044292
GeneOntologyCellularComponentaxonal growth cone

CYFIP1 HSP90AA1

8.40e-0445202GO:0044295
DomainCytoplasmic_FMR1-int

CYFIP2 CYFIP1

1.09e-062202IPR008081
DomainFragX_IP

CYFIP2 CYFIP1

1.09e-062202PF05994
DomainDUF1394

CYFIP2 CYFIP1

6.53e-064202PF07159
DomainDUF1394

CYFIP2 CYFIP1

6.53e-064202IPR009828
Domainzf-UBP

USP3 USP22

9.84e-0514202PF02148
DomainZF_UBP

USP3 USP22

9.84e-0514202PS50271
DomainZnf_UBP

USP3 USP22

9.84e-0514202IPR001607
DomainUSP_CS

USP3 USP22

2.24e-0366202IPR018200
DomainUSP_1

USP3 USP22

2.52e-0370202PS00972
DomainUCH

USP3 USP22

2.59e-0371202PF00443
DomainUSP_2

USP3 USP22

2.59e-0371202PS00973
DomainUSP_dom

USP3 USP22

2.66e-0372202IPR028889
DomainPeptidase_C19_UCH

USP3 USP22

2.66e-0372202IPR001394
DomainUSP_3

USP3 USP22

2.66e-0372202PS50235
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK8 CYFIP2 CYFIP1 MPP7

2.08e-05175144MM15599
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK8 CYFIP2 CYFIP1 MPP7

2.54e-05184144M41809
PathwayREACTOME_RHO_GTPASE_CYCLE

DOCK8 CYFIP2 CYFIP1 HSP90AA1 MPP7

4.54e-05439145MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

DOCK8 CYFIP2 CYFIP1 HSP90AA1 MPP7

5.11e-05450145M27078
PathwayREACTOME_SIGNALING_BY_VEGF

CYFIP2 CYFIP1 HSP90AA1

1.30e-04103143MM14752
PathwayREACTOME_SIGNALING_BY_VEGF

CYFIP2 CYFIP1 HSP90AA1

1.42e-04106143M27077
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY

CYFIP2 CYFIP1

1.72e-0420142M47737
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

CYFIP2 CYFIP1 HSP90AA1

1.76e-04114143MM14814
PathwayKEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYFIP2 CYFIP1

2.71e-0425142M47716
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

DOCK8 CYFIP2 CYFIP1 HSP90AA1 MPP7

2.88e-04649145MM15690
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

CYFIP2 CYFIP1 HSP90AA1

3.43e-04143143M27107
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYFIP2 CYFIP1

3.66e-0429142M47717
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYFIP2 CYFIP1

3.92e-0430142M47738
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

DOCK8 CYFIP2 CYFIP1 HSP90AA1 MPP7

4.66e-04720145M41838
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

CYFIP2 CYFIP1

5.05e-0434142MM15265
PathwayREACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES

CYFIP2 CYFIP1

5.66e-0436142M27549
PathwayREACTOME_LEISHMANIA_INFECTION

C3 CYFIP2 CYFIP1

1.19e-03219143M29836
PathwayREACTOME_RHOJ_GTPASE_CYCLE

DOCK8 MPP7

1.32e-0355142M41815
PathwayREACTOME_AURKA_ACTIVATION_BY_TPX2

HAUS6 HSP90AA1

2.19e-0371142MM15495
PathwayREACTOME_RHOG_GTPASE_CYCLE

CYFIP1 MPP7

2.19e-0371142MM15604
PathwayREACTOME_AURKA_ACTIVATION_BY_TPX2

HAUS6 HSP90AA1

2.25e-0372142M27749
PathwayREACTOME_RHOG_GTPASE_CYCLE

CYFIP1 MPP7

2.37e-0374142M41814
PathwayREACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES

HAUS6 HSP90AA1

2.84e-0381142M748
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

HAUS6 HSP90AA1

3.12e-0385142MM14906
PathwayREACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION

HAUS6 HSP90AA1

3.27e-0387142M27194
PathwayREACTOME_RAC2_GTPASE_CYCLE

CYFIP1 MPP7

3.27e-0387142MM15600
PathwayREACTOME_RAC2_GTPASE_CYCLE

CYFIP1 MPP7

3.34e-0388142M41810
PathwayREACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES

HAUS6 HSP90AA1

3.49e-0390142MM14979
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

C3 DEFB134 CYFIP2 CYFIP1 HSP90AA1

3.53e-031128145M1036
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYFIP1 MPP7

3.72e-0393142MM15609
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYFIP1 MPP7

3.80e-0394142M41818
PathwayREACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES

HAUS6 HSP90AA1

3.88e-0395142M6729
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

HAUS6 HSP90AA1

3.96e-0396142MM15207
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

HAUS6 HSP90AA1

4.04e-0397142M27478
Pubmed

Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.

CYFIP2 CYFIP1

3.47e-07221238128786
Pubmed

Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.

CYFIP2 CYFIP1

3.47e-07221234327661
Pubmed

Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance.

ABCC1 USP22

3.47e-07221235203285
Pubmed

Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?

HSP90AA1 USP22

3.47e-07221230598339
Pubmed

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.

CYFIP2 CYFIP1

3.47e-07221224357318
Pubmed

Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.

CYFIP2 CYFIP1

3.47e-07221229752658
Pubmed

Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.

CYFIP2 CYFIP1

3.47e-07221235567753
Pubmed

Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.

CYFIP2 CYFIP1

3.47e-07221231324746
Pubmed

[Role of ubiquitin-specific peptidase 22 in multidrug resistance of colorectal cancer and its correlation with multidrug resistance gene P-gp].

ABCC1 USP22

1.04e-06321234954996
Pubmed

Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.

CYFIP2 CYFIP1

2.08e-06421215294869
Pubmed

Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.

CYFIP2 CYFIP1

2.08e-06421227605705
Pubmed

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

CYFIP2 CYFIP1

2.08e-06421220228810
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ABCC1 CYFIP2 CYFIP1 MPP7 OCLN

4.40e-0642121536976175
Pubmed

Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.

CYFIP2 CYFIP1

5.20e-06621231853374
Pubmed

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.

CYFIP2 CYFIP1

5.20e-06621211438699
Pubmed

Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice.

CYFIP2 CYFIP1

7.28e-06721230687000
Pubmed

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.

CYFIP2 CYFIP1 HSP90AA1

9.27e-066821314676191
Pubmed

USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.

HSP90AA1 USP22

1.25e-05921222542455
Pubmed

Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.

CYFIP2 CYFIP1

1.25e-05921238981622
Pubmed

IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection.

DOCK8 C3

1.56e-051021231231033
Pubmed

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

CYFIP2 CYFIP1

1.56e-051021215048123
Pubmed

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

USP3 USP22

2.28e-051221227801882
Pubmed

Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.

CYFIP2 CYFIP1

2.70e-051321234508581
Pubmed

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.

CYFIP2 CYFIP1

5.28e-05182129463375
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

HAUS6 CYFIP1 HSP90AA1 MPP7 OCLN

5.35e-0570821539231216
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

DOCK8 ABCC1 CYFIP1

6.03e-0512721330442766
Pubmed

USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.

USP3 USP22

7.96e-052221235640597
Pubmed

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.

CYFIP2 CYFIP1

7.96e-052221221946561
Pubmed

Proteome-scale Binary Interactomics in Human Cells.

ABCC1 HSP90AA1

1.81e-043321227803151
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

ABCC1 CYFIP1 HSP90AA1 OCLN

1.84e-0448421431995728
Pubmed

α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

CYFIP1 OCLN

2.04e-043521237381005
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

ZMYM2 HAUS6 CYFIP1 OCLN

3.20e-0456021435241646
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

C3 HSP90AA1

3.24e-044421231273033
Pubmed

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

ABCC1 CYFIP2 CYFIP1 HSP90AA1

3.31e-0456521420458337
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ABCC1 KLHL15 CYFIP2 HSP90AA1 MPP7

3.36e-04104921527880917
InteractionZNF511 interactions

KLHL15 CYFIP2 CYFIP1

8.70e-0641203int:ZNF511
InteractionAMZ1 interactions

HAUS6 CYFIP2 CYFIP1

1.08e-0544203int:AMZ1
InteractionLETM2 interactions

LETM2 HSP90AA1

1.96e-057202int:LETM2
InteractionKCTD8 interactions

CYFIP2 HSP90AA1

2.61e-058202int:KCTD8
InteractionC4A interactions

C3 HSP90AA1 OCLN

4.77e-0572203int:C4A
InteractionEPHA2 interactions

ABCC1 CYFIP2 CYFIP1 HSP90AA1 MPP7 OCLN

5.10e-05719206int:EPHA2
InteractionLYN interactions

ABCC1 CYFIP2 CYFIP1 HSP90AA1 MPP7 OCLN

5.14e-05720206int:LYN
InteractionNYAP1 interactions

CYFIP2 CYFIP1

7.25e-0513202int:NYAP1
InteractionDLGAP4 interactions

CYFIP2 MPP7 OCLN

7.57e-0584203int:DLGAP4
InteractionMYO16 interactions

CYFIP2 CYFIP1

1.11e-0416202int:MYO16
InteractionCGB2 interactions

CYFIP2 CYFIP1

1.42e-0418202int:CGB2
InteractionEPHA7 interactions

CYFIP2 CYFIP1 MPP7 OCLN

1.52e-04282204int:EPHA7
InteractionNCKAP1L interactions

CYFIP2 CYFIP1

1.76e-0420202int:NCKAP1L
InteractionNHSL3 interactions

CYFIP2 CYFIP1 OCLN

1.83e-04113203int:NHSL3
InteractionGJA1 interactions

ABCC1 C3 CYFIP2 MPP7 OCLN

2.15e-04583205int:GJA1
InteractionC11orf52 interactions

ABCC1 CYFIP1 MPP7 OCLN

2.22e-04311204int:C11orf52
InteractionPRKCG interactions

CYFIP1 HSP90AA1 OCLN

2.23e-04121203int:PRKCG
InteractionNYAP2 interactions

CYFIP2 CYFIP1

2.34e-0423202int:NYAP2
InteractionNPHP1 interactions

C3 HSP90AA1 USP22

2.76e-04130203int:NPHP1
InteractionRAC3 interactions

ABCC1 CYFIP2 CYFIP1 MPP7 OCLN

2.84e-04619205int:RAC3
InteractionRHOJ interactions

DOCK8 ABCC1 CYFIP1 MPP7 OCLN

3.15e-04633205int:RHOJ
InteractionLCTL interactions

USP22 OCLN

3.24e-0427202int:LCTL
InteractionLAMP1 interactions

ABCC1 CYFIP2 CYFIP1 MPP7 OCLN

3.41e-04644205int:LAMP1
InteractionUSP31 interactions

HSP90AA1 OCLN

3.48e-0428202int:USP31
InteractionWASF2 interactions

CYFIP2 CYFIP1 OCLN

3.88e-04146203int:WASF2
InteractionRHOF interactions

DOCK8 ABCC1 CYFIP1 MPP7 OCLN

4.18e-04673205int:RHOF
InteractionRAC2 interactions

ABCC1 CYFIP2 CYFIP1 MPP7 OCLN

4.21e-04674205int:RAC2
InteractionRPS6KC1 interactions

HSP90AA1 OCLN

4.28e-0431202int:RPS6KC1
InteractionFASN interactions

ZNF236 USP3 ABCC1 HAUS6 HSP90AA1 USP22

4.32e-041062206int:FASN
InteractionRAC1 interactions

DOCK8 ABCC1 CYFIP2 CYFIP1 MPP7 OCLN

4.34e-041063206int:RAC1
InteractionYES1 interactions

CYFIP2 CYFIP1 HSP90AA1 OCLN

4.51e-04375204int:YES1
InteractionTNIK interactions

ZMYM2 CYFIP2 CYFIP1 OCLN

4.79e-04381204int:TNIK
InteractionNRAS interactions

DOCK8 ABCC1 CYFIP1 MPP7 OCLN

4.97e-04699205int:NRAS
InteractionDCLK2 interactions

KLHL15 HSP90AA1

5.15e-0434202int:DCLK2
InteractionHRAS interactions

DOCK8 ABCC1 CYFIP1 MPP7 OCLN

5.87e-04725205int:HRAS
InteractionTMEM17 interactions

ABCC1 CYFIP1 MPP7 OCLN

5.98e-04404204int:TMEM17
InteractionFKBPL interactions

CYFIP1 HSP90AA1

6.10e-0437202int:FKBPL
InteractionSPTBN2 interactions

CYFIP2 CYFIP1 OCLN

6.26e-04172203int:SPTBN2
InteractionSIRT1 interactions

ZNF236 HSP90AA1 USP22 OCLN

6.43e-04412204int:SIRT1
InteractionGAS7 interactions

CYFIP2 CYFIP1

6.44e-0438202int:GAS7
InteractionNTRK2 interactions

CYFIP1 HSP90AA1 OCLN

6.69e-04176203int:NTRK2
InteractionSPTBN1 interactions

CYFIP2 CYFIP1 HSP90AA1 OCLN

6.98e-04421204int:SPTBN1
InteractionCAMK2B interactions

CYFIP2 CYFIP1 HSP90AA1

7.38e-04182203int:CAMK2B
InteractionSHANK1 interactions

CYFIP2 CYFIP1

7.50e-0441202int:SHANK1
InteractionSERPING1 interactions

C3 HSP90AA1

7.87e-0442202int:SERPING1
InteractionEPHA4 interactions

CYFIP2 HSP90AA1 OCLN

8.10e-04188203int:EPHA4
InteractionRND2 interactions

ABCC1 CYFIP1 MPP7 OCLN

8.23e-04440204int:RND2
InteractionMATK interactions

CYFIP2 HSP90AA1

8.25e-0443202int:MATK
InteractionRHOQ interactions

DOCK8 ABCC1 MPP7 OCLN

8.37e-04442204int:RHOQ
InteractionKLHL23 interactions

HSP90AA1 USP22

8.63e-0444202int:KLHL23
InteractionCFB interactions

C3 HSP90AA1

8.63e-0444202int:CFB
InteractionAPBB1 interactions

CYFIP2 CYFIP1 OCLN

9.01e-04195203int:APBB1
InteractionRPS6KA2 interactions

HSP90AA1 MPP7 OCLN

9.14e-04196203int:RPS6KA2
InteractionLRP1 interactions

USP3 C3 HSP90AA1

9.14e-04196203int:LRP1
InteractionPRKX interactions

C3 HSP90AA1

9.43e-0446202int:PRKX
InteractionGUCY1B1 interactions

HSP90AA1 MPP7

9.85e-0447202int:GUCY1B1
GeneFamilyUbiquitin specific peptidases

USP3 USP22

8.37e-0456142366
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK8 HAUS6 KLHL15 HSP90AA1

2.05e-0619821493cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3 CYFIP2

5.60e-051602131f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3 CYFIP2

6.14e-05165213ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCell(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)|(1)_Control_(PBS) / Stress and Cell class

C3 CYFIP2 HSP90AA1

7.56e-05177213d9e5ac5b8949a77e88e8094079167e4cf2c1bbd1
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF236 ABCC1 KLHL15

7.94e-05180213551b8de8d933d11bcd3897aeb2fd033355f958e2
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC1 CYFIP2 OCLN

8.34e-0518321303c7e69136d5a3b9c5b2c91733e9b1c791f45c49
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

8.34e-0518321362f76907e501bba6e1010b5c447faed5f0ef93a7
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CYFIP2 MPP7 OCLN

9.32e-05190213c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CYFIP2 MPP7 OCLN

9.62e-0519221325378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CYFIP2 MPP7 OCLN

9.62e-05192213b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

9.62e-0519221369758a256386a6ed3a6e2c94c55d59baa34892d7
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

USP3 DOCK8 HSP90AA1

9.62e-051922130b9d22a222f1201e375f8e55cace9ef939febae4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

9.76e-05193213b52d5661edff83ac4c5fe2bf89d6672016bb827b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

9.76e-05193213697518bab1338dc441b2d93b410d957e692f20e6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

1.01e-04195213b6bf75669f267ecdc96818c7022db852e37a9fe1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

1.02e-04196213e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

1.05e-0419821300a54af5267bfe0eeab6720bf890dc4b6b803bfd
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK8 HAUS6 KLHL15

1.07e-041992135b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

1.07e-04199213b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK8 C3 CYFIP1

1.07e-04199213e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-04200213dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-04200213a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-0420021321bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-042002133bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-0420021333036d21c1c82109284473a515c4f890b33fdd5c
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

DOCK8 C3 CYFIP1

1.08e-04200213a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK8 CYFIP2 HSP90AA1

1.08e-04200213893bb7c25ad7c6589a4c7c0364c2ace666e9b4be
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZMYM2 USP22

1.19e-03109212cc43c221487a712546917cc3253c158a1fc1fd7a
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 OCLN

1.68e-031302126434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellNS-moderate-d_07-13-Epithelial-IRC-IFNG_responsive_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

C3 HSP90AA1

1.83e-031362127f1ca43e0d164b511120316d4218d80ba21a9b5c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C3 CYFIP1

2.08e-031452129743d68ba8bfef56fd9a979ab357c0e287eb5ae2
ToppCelllung-Type_II_Pneumocytes|lung / shred on tissue and cell subclass

C3 CYFIP2

2.14e-031472128a3039de45b8087f8319e2e37329acf7278219b7
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MPP7 OCLN

2.20e-031492129286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZMYM2 LETM2

2.20e-0314921265778f19599b4955c0a16f0121237656449431fb
ToppCellLeuk-UTI-Lymphocyte-T_NK-dnT|Leuk-UTI / Disease, Lineage and Cell Type

GTSF1L ABCC1

2.20e-0314921253f145cf7089d948d41aa3c443e983e011826836
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MPP7 OCLN

2.20e-03149212f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCelldroplet-Kidney-nan-24m-Lymphocytic-CD45____macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3

2.22e-0315021234774b015adecc2be56a471fda8994e89a6ad93e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C3 CYFIP1

2.25e-031512122f9b3e14c2fa6e2b1976ca6ab2031b63bf5e3e64
ToppCelldroplet-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.31e-03153212f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCelldroplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.31e-031532126dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

CYFIP2 MPP7

2.31e-03153212ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellIIH-Treg|IIH / Condition, Cell_class and T cell subcluster

GTSF1L LETM2

2.31e-0315321217704e18833812fcf2a2727b1e3f8a9984ba5b59
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.34e-031542121e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCellIIH-Treg-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

GTSF1L LETM2

2.34e-03154212d2211a892654b92decb208969040920f7ae8ba1e
ToppCellLPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LETM2 DDIAS

2.37e-031552124559e3011514041b65c17ae4ede29da202bce14c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C3 CYFIP1

2.40e-03156212e0aef6104be16b12304b8e30358f444c1660e92f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

C3 CYFIP1

2.40e-031562125b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCellPND07-28-samps-Myeloid-Granulocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NXPE4 CYFIP2

2.40e-031562125e1c5a7c9293b886920739cf766521df7f69726c
ToppCellPND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NXPE4 CYFIP2

2.40e-03156212166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KLHL15 HSP90AA1

2.43e-031572122c767c526abcc8adea6ec4eb2cc333060bb213b5
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYFIP2 MPP7

2.43e-03157212a426c54fd1545093d41426e9620862f71bd06f6b
ToppCellfacs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.43e-031572129d4308312301cb922f156a7b6aededc9e1c62807
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

C3 CYFIP1

2.43e-03157212d4908cafd8870c1c225817f589ea2bce116ac7ab
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK8 CYFIP2

2.46e-03158212121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSP90AA1 MPP7

2.46e-03158212de65af8d3b8514b17978155f31975e2347b75251
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK8 C3

2.49e-031592120c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

C3 CYFIP1

2.49e-0315921231ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCell343B-Myeloid-Mast_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

LETM2 HSP90AA1

2.52e-03160212a2f09b5955602819c8978f4372130c8ef915cd07
ToppCell343B-Myeloid-Mast_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

LETM2 HSP90AA1

2.52e-03160212133ecae0a894d9a0d49d58859623359096b6f030
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK8 CYFIP2

2.52e-03160212bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CYFIP2 OCLN

2.52e-0316021203b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.52e-031602122020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 MPP7

2.52e-031602121e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.52e-03160212af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDIAS ABCC1

2.56e-03161212a7e74bc80ac11250e353e5614b19c05793fc2e95
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DDIAS HAUS6

2.56e-031612125fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCellfacs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.59e-031622123fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCellfacs-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.59e-031622128134f73eb76693f4f1845f643042fdc1e81c274c
ToppCellfacs-Lung-EPCAM-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.59e-03162212484ea4ac40de672dcbd2583a52cb7f385c918814
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.59e-03162212bba144ac5332bab9eba2ccf599703c781a7f88f1
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK8 C3

2.59e-031622129d6931619f5eb847c79d00ff5ae031fef30fd55c
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-6|TCGA-Adrenal / Sample_Type by Project: Shred V9

C3 MPP7

2.59e-031622120e8fb83acb8ea9905cc3ca985feb8a00931549ff
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC1 NXPE4

2.62e-031632128dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NXPE4 CYFIP2

2.62e-03163212f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 HSP90AA1

2.62e-03163212fd35f1237c23367753ac2bc3e893f0e3c714129c
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC1 NXPE4

2.62e-03163212fd243ca223079033be480a24817a399f281fa4d4
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 C3

2.62e-031632128028636632c168dc50731d0ebecaf88a70daf81d
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDIAS HAUS6

2.62e-03163212953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NXPE4 CYFIP2

2.65e-03164212ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.65e-0316421215d52666e5150e7c34b1f641a937fb2d5e8aaf8a
ToppCellfacs-Lung-EPCAM-24m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYFIP2

2.65e-03164212d622f0d8d8bad48dfdf160ec63c545df192637a9
ToppCellfacs-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK8 CYFIP2

2.65e-0316421211dfd84f5fb90de330858e1e852848832734e004
ToppCelldroplet-Heart-4Chambers-18m-Myeloid-cardiac_mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.68e-03165212a761e0a36d5da8fec916d684f81e60f5590fd9ee
ToppCelldroplet-Heart-4Chambers-18m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.68e-03165212af423307af484661284793a08091777d998e6fba
ToppCelldroplet-Heart-4Chambers-18m-Myeloid-mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CYFIP2

2.68e-03165212680bdd150bc0a4e50244e57b1226a9b06a6bdbc9
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

ABCC1 HAUS6

2.71e-03166212c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCelldroplet-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3

2.71e-03166212e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCelldroplet-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3

2.71e-031662123ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCell343B-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LETM2 HSP90AA1

2.71e-031662124e47e7f3019fb2dcbc35b4e9b47ee265a97cec5c
ToppCell343B-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LETM2 HSP90AA1

2.71e-03166212f6e2ec767c022982ef416fadb998a7b6b958f76a
ToppCelldroplet-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3

2.71e-03166212f751cbd01d4978ded7755874ab60504f6291afd7
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NXPE4 CYFIP2

2.71e-031662121a3a15d1fc76bb91d832cdc6e3da0a6140b94b75
ToppCellControl-Lymphocytic_B|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK8 CYFIP2

2.75e-03167212956da82394fd6a9f45fc2031796f12cc889542cd
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CYFIP2 OCLN

2.75e-0316721225af48c640e67848594f5902867ba325fc105da4
ToppCellControl-Lymphocytic_B-B_cells-B-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK8 CYFIP2

2.75e-0316721269ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C3 CYFIP1

2.75e-03167212942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCellControl-Lymphocytic_B-B_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK8 CYFIP2

2.75e-03167212a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

USP3 ABCC1

2.75e-03167212ced6ed9b412739c6ced622523347c10295edbf53
ToppCelldroplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NXPE4 CYFIP2

2.78e-03168212d823979335ac6b5d1f062ebb741c759d2f919dbf
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 C3

2.78e-03168212f3b7a7df54988de77dcc7066e2fc1feb9c280b13
Drugnitazoxanide

DOCK8 ABCC1

2.63e-059202ctd:C041747
DrugI-hu

C3 HSP90AA1

4.01e-0511202CID009547901
DrugCL-387,785

ABCC1 HSP90AA1

1.38e-0420202CID000002776
Drugestradiol-17 beta-glucuronide

ABCC1 OCLN

1.68e-0422202ctd:C025483
Drug2-amino-2-methyl-1-propanol

CCDC30 DDIAS C3 OCLN

2.09e-04346204ctd:C006551
Drug9-NC

ABCC1 C3

3.81e-0433202CID000123613
DrugAC1LBSPF

C3 HSP90AA1

4.04e-0434202CID000541529
Drug1uy8

C3 HSP90AA1

4.54e-0436202CID005289228
Druglaulimalide

C3 HSP90AA1

5.06e-0438202CID006918457
Drugindium trichloride

C3 HSP90AA1

5.89e-0441202ctd:C020758
DrugTestosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ZNF236 ZMYM2 ABCC1

6.33e-041952032649_DN
DrugHydrochlorothiazide [58-93-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A

ZNF236 CCDC30 CYFIP2

6.43e-041962031487_UP
DrugPraziquantel [55268-74-1]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ZMYM2 ABCC1 CYFIP2

6.43e-041962037228_DN
DrugSuccinylsulfathiazole [116-43-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A

ZMYM2 C3 CYFIP2

6.52e-041972032821_UP
DrugXylazine [7361-61-7]; Down 200; 18.2uM; HL60; HT_HG-U133A

ZNF236 ZMYM2 C3

6.72e-041992032132_DN
Drugzileuton

ABCC1 OCLN

7.74e-0447202ctd:C063449
DrugAdenosine Diphosphate

ABCC1 HSP90AA1

9.11e-0451202ctd:D000244
Drug8-prenylnaringenin

ABCC1 C3

9.47e-0452202CID000480764
Drugisoxazole

ABCC1 HSP90AA1

1.10e-0356202CID000009254
DrugProbenecid

ABCC1 OCLN

1.22e-0359202ctd:D011339
Druggefitinib

ABCC1 CYFIP1 HSP90AA1

1.37e-03255203CID000123631
Drugcoumestrol

C3 HSP90AA1

1.66e-0369202CID005281707
Diseasechromosome 15q11.2 deletion syndrome (implicated_via_orthology)

CYFIP2 CYFIP1

1.45e-063212DOID:0060393 (implicated_via_orthology)
Diseaseprostate carcinoma, type 2 diabetes mellitus

ZNF236 HAUS6

8.05e-0459212EFO_0001663, MONDO_0005148
Diseaserheumatoid arthritis (is_marker_for)

C3 HSP90AA1

1.10e-0369212DOID:7148 (is_marker_for)
DiseaseDrug toxicity

ABCC1 C3

1.62e-0384212C0013221
DiseaseAdverse reaction to drug

ABCC1 C3

1.62e-0384212C0041755
Diseasechronic obstructive pulmonary disease (is_marker_for)

ABCC1 C3

2.16e-0397212DOID:3083 (is_marker_for)
DiseaseAcute kidney injury

C3 OCLN

2.33e-03101212C2609414
DiseaseKidney Failure, Acute

C3 OCLN

2.33e-03101212C0022660
DiseaseAcute Kidney Insufficiency

C3 OCLN

2.33e-03101212C1565662

Protein segments in the cluster

PeptideGeneStartEntry
TMYHAKAKDQLTCNK

C3

1346

P01024
KLIQKYKEAMSNKAC

MKRN4P

391

Q13434
ADYKSKKNHCKQLKS

OCLN

491

Q16625
NMKCSVKNDHSAYKR

CYFIP1

176

Q7L576
SHLNKTCMKNYESKK

LETM2

41

Q2VYF4
YAAKKHMKKCSSSLA

nan

1086

O00370
KAKKMATCKYNACHV

GTSF1L

36

Q9H1H1
TSFKNNSKEKCSLKH

FAM214A

566

Q32MH5
AAVVTKKKTHKYNCK

DDIAS

926

Q8IXT1
KKTNKSMYECKKSDQ

MPP7

331

Q5T2T1
NMKCSVKNDHSAYKR

CYFIP2

176

Q96F07
INSLSSEMHKKCYKN

DEFB134

21

Q4QY38
KSKMNYARCFHKMIS

KLHL15

471

Q96M94
QNMAEKHTKKKCYTE

DOCK8

1646

Q8NF50
KHTKKKCYTEAAMCL

DOCK8

1651

Q8NF50
KHAQQKLLDSTKMCS

CCDC30

291

Q5VVM6
AMKYIKSNSKNSSHH

HAUS6

136

Q7Z4H7
SLKDYCTRMKENQKH

HSP90AA1

476

P07900
KTKTYQVAHMKSKDN

ABCC1

486

P33527
CAALTHMYSKNKKVS

NXPE4

251

Q6UWF7
CHSYQESTKQLTMKK

USP22

386

Q9UPT9
CMNSHKTKYAKSQSL

ZMYM2

566

Q9UBW7
ELYMCHKCKKKQKST

USP3

381

Q9Y6I4
CQKTFKTSLNCKKHM

ZNF236

746

Q9UL36
KTSLNCKKHMKTHRY

ZNF236

751

Q9UL36