Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LRRC37_N	LRRC37A LRRC37A2	1.49e-05	4	30	2	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A2	1.49e-05	4	30	2	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37A2	1.49e-05	4	30	2	IPR029423
Domain	LRRC37	LRRC37A LRRC37A2	1.49e-05	4	30	2	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A2	1.49e-05	4	30	2	IPR015753
Domain	ARM-like	IPO5 PKP1 HUWE1	9.09e-03	270	30	3	IPR011989
Pubmed	Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm.	HUWE1 CDCP1	2.46e-06	3	32	2	34909679
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A2	4.92e-06	4	32	2	22419166
Pubmed	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.	HUWE1 KBTBD4 MZB1 NDUFB8 ANAPC15	1.00e-05	317	32	5	11042152
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	IPO5 HUWE1 CDCP1 ANKLE2 SVIL	1.25e-05	332	32	5	37433992
Pubmed	Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.	TNFRSF11A NUP205	2.94e-05	9	32	2	21623375
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A2	3.67e-05	10	32	2	23064749
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	IPO5 HUWE1	4.49e-05	11	32	2	11809816
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	KNDC1 PKP1 ZDBF2 HUWE1 ANKLE2 RUFY3 SYNGR1	6.51e-05	1139	32	7	36417873
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZDBF2 CEP192 HUWE1	1.11e-04	101	32	3	10997877
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TBC1D9B ANKLE2 EXPH5	1.14e-04	102	32	3	9734811
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZDBF2 CEP192 ZZZ3 HUWE1 RUFY3	1.87e-04	588	32	5	38580884
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C CEP192 HUWE1 CDCP1 ANKLE2 ANAPC15	4.09e-04	1084	32	6	11544199
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	PKP1 HUWE1	4.25e-04	33	32	2	26296893
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HUWE1 KBTBD4	5.07e-04	36	32	2	35379950
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	IPO5 NUP205	6.26e-04	40	32	2	37516964
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP192 ANKLE2 SVIL	6.45e-04	184	32	3	32908313
Pubmed	FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.	CEP192 NUP205	6.90e-04	42	32	2	29348145
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	IPO5 HUWE1	6.90e-04	42	32	2	32738194
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	IPO5 KMT2C HUWE1 NUP205	8.70e-04	469	32	4	27634302
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	IPO5 KMT2C	9.01e-04	48	32	2	27703004
Interaction	KRT18 interactions	IPO5 CREBRF PKP1 CEP192 HUWE1 SVIL NUP205	2.73e-06	419	31	7	int:KRT18
Interaction	USP50 interactions	IPO5 HUWE1 NUP205	2.09e-05	35	31	3	int:USP50
Cytoband	17q21.31	LRRC37A LRRC37A2	1.51e-03	82	32	2	17q21.31
Coexpression	MURARO_PANCREAS_BETA_CELL	CREBRF KMT2C TBC1D9B TNFRSF11A ZZZ3 HUWE1 CDCP1 EXPH5 RUFY3	1.33e-06	946	32	9	M39169
Disease	Osteitis Deformans	TNFRSF11A NUP205	3.83e-05	9	31	2	C0029401
Disease	osteitis deformans	TNFRSF11A NUP205	8.27e-05	13	31	2	EFO_0004261
Disease	Acute Myeloid Leukemia, M1	KMT2C SVIL SYNGR1	3.06e-04	125	31	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	KMT2C SVIL SYNGR1	3.06e-04	125	31	3	C1879321
Disease	Leukemia, Myelocytic, Acute	KMT2C SVIL SYNGR1	7.89e-04	173	31	3	C0023467
Disease	Arsenic Induced Polyneuropathy	NDUFB8 RUFY3	1.94e-03	62	31	2	C0751852
Disease	Arsenic Encephalopathy	NDUFB8 RUFY3	1.94e-03	62	31	2	C0751851
Disease	Arsenic Poisoning	NDUFB8 RUFY3	1.94e-03	62	31	2	C0311375
Disease	Arsenic Poisoning, Inorganic	NDUFB8 RUFY3	1.94e-03	62	31	2	C0274861
Disease	Nervous System, Organic Arsenic Poisoning	NDUFB8 RUFY3	1.94e-03	62	31	2	C0274862
Disease	Parkinson's disease (is_marker_for)	NDUFB8 GDNF	2.26e-03	67	31	2	DOID:14330 (is_marker_for)
Disease	Dermatologic disorders	NDUFB8 RUFY3	2.83e-03	75	31	2	C0037274

Protein segments in the cluster

Peptide	Gene	Start	Entry
MQDMDEMNDYNESPD	ANAPC15	86	P60006
NPDFMRLMYPDDDEA	ANKLE2	376	Q86XL3
MSANYPEGFPEDELM	CDCP1	236	Q9H5V8
SSDPDFMYELDREMN	CREBRF	36	Q8IUR6
QVYDMRPETDPQSMF	NUP205	1586	Q92621
DYNNEMEVEGPEDQM	KMT2C	541	Q8NEZ4
AFEENDFMENTNMPE	LRRC37A2	1396	A6NM11
AFEENDFMENTNMPE	LRRC37A	1396	A6NMS7
MPMYNFDPTEEQDEL	C3orf18	96	Q9UK00
AMSPDTFENSENMPF	EXPH5	436	Q8NEV8
SNMPEDYPDQFDDVM	GDNF	51	P39905
NMRVEDYEPYPDDGM	NDUFB8	56	O95169
FNDMEDDDPQISYMI	IPO5	591	O00410
DGSEMELDEDYPDMN	HUWE1	2461	Q7Z6Z7
PQADDQDMMESLFYT	OR5H6	281	Q8NGV6
VSMPDYMVHEEFNPD	C7orf57	121	Q8NEG2
NHMMPASYDGQDPEF	CEP192	1576	Q8TEP8
MDNSMVSDPQPYHED	KIAA1210	641	Q9ULL0
MQAMDPAAADLYEED	KNDC1	1	Q76NI1
MNEVDFYEPFMDEPI	CASQ2	211	O14958
AYPEQRQDMPEMSQE	DPPA2	126	Q7Z7J5
MMNNNYDCPLPEEET	PKP1	521	Q13835
SEFYEPNALMMEEEG	RUFY3	191	Q7L099
DYNMPRSPVEMDEDF	SVIL	1316	O95425
MESPEEPGASMDENY	KBTBD4	1	Q9NVX7
NMFSEDPMEQDLYHA	TBC1D9B	1036	Q66K14
MDDADPEERNYDNML	SYCE3	1	A1L190
DQPSDSEMMYDSDVP	ZDBF2	1491	Q9HCK1
FSQDYMDPSQDSSMP	SYNGR1	181	O43759
FMTSHEPPVYMDEDD	ZZZ3	746	Q8IYH5
EEDSFRQMPTEDEYM	TNFRSF11A	336	Q9Y6Q6
APQLDDEEMYSAHMP	MZB1	31	Q8WU39