Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	EZR MYH1 MYH13 SPTB SPTBN1 ARPC1A NEXN PICK1	1.01e-06	227	68	8	GO:0051015
GeneOntologyMolecularFunction	cytoskeletal protein binding	EZR RALA HAUS8 MYH1 MYH13 MAP7D3 TTLL6 SPTB SPTBN1 ARPC1A MICAL3 CEP295 KIFC3 NEXN PICK1	3.31e-06	1099	68	15	GO:0008092
GeneOntologyMolecularFunction	actin binding	EZR MYH1 MYH13 SPTB SPTBN1 ARPC1A MICAL3 NEXN PICK1	3.43e-05	479	68	9	GO:0003779
GeneOntologyMolecularFunction	ATP-dependent activity	DDX47 MYH1 IQCA1L ATAD3B MYH13 ATAD3A DQX1 CHTF18 KIFC3	2.27e-04	614	68	9	GO:0140657
GeneOntologyCellularComponent	supramolecular fiber	EZR HAUS8 MYH1 MYH13 TTLL6 SPTBN1 EVPL CEP295 GCK LMNB2 CFAP210 KIFC3 NEXN	5.77e-05	1179	65	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	EZR HAUS8 MYH1 MYH13 TTLL6 SPTBN1 EVPL CEP295 GCK LMNB2 CFAP210 KIFC3 NEXN	6.19e-05	1187	65	13	GO:0099081
GeneOntologyCellularComponent	actin cytoskeleton	EZR MYH1 MYH13 SPTB SPTBN1 ARPC1A GCK NEXN NCOA5	6.96e-05	576	65	9	GO:0015629
GeneOntologyCellularComponent	cell cortex	EZR PNMA5 PTK2B SPTB SPTBN1 MICAL3 GCK	1.51e-04	371	65	7	GO:0005938
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1	3.38e-04	9	65	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTB SPTBN1	3.38e-04	9	65	2	GO:0008091
GeneOntologyCellularComponent	spindle	PNMA5 HAUS8 NSFL1C MAP7D3 IKBKG MICAL3 CEP295	6.36e-04	471	65	7	GO:0005819
GeneOntologyCellularComponent	mitotic spindle microtubule	HAUS8 CEP295	8.46e-04	14	65	2	GO:1990498
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH13	1.11e-03	16	65	2	GO:0005859
MousePheno	small embryonic epiblast	ATAD3B ATAD3A ZWINT	2.02e-05	15	51	3	MP:0011189
Domain	DUF3523	ATAD3B ATAD3A	3.79e-05	3	67	2	PF12037
Domain	DUF3523	ATAD3B ATAD3A	3.79e-05	3	67	2	IPR021911
Domain	Spectrin_bsu	SPTB SPTBN1	7.57e-05	4	67	2	IPR016343
Domain	Spectrin_repeat	SPTB SPTBN1 EVPL	1.51e-04	29	67	3	IPR002017
Domain	Spectrin/alpha-actinin	SPTB SPTBN1 EVPL	2.03e-04	32	67	3	IPR018159
Domain	SPEC	SPTB SPTBN1 EVPL	2.03e-04	32	67	3	SM00150
Domain	PNMA	PNMA5 PNMA6A	6.83e-04	11	67	2	PF14893
Domain	PNMA	PNMA5 PNMA6A	6.83e-04	11	67	2	IPR026523
Domain	P-loop_NTPase	DDX47 RALA MYH1 ATAD3B MYH13 SULT1C2 ATAD3A DQX1 CHTF18 KIFC3	8.36e-04	848	67	10	IPR027417
Domain	AAA	ATAD3B ATAD3A CHTF18	8.60e-04	52	67	3	PF00004
Domain	ATPase_AAA_core	ATAD3B ATAD3A CHTF18	9.60e-04	54	67	3	IPR003959
Domain	NPIP	NPIPB8 NPIPB6	1.12e-03	14	67	2	IPR009443
Domain	Myosin_N	MYH1 MYH13	1.29e-03	15	67	2	PF02736
Domain	Myosin_N	MYH1 MYH13	1.29e-03	15	67	2	IPR004009
Domain	CH	SPTB SPTBN1 MICAL3	1.64e-03	65	67	3	SM00033
Domain	Myosin_tail_1	MYH1 MYH13	1.87e-03	18	67	2	PF01576
Domain	Myosin_tail	MYH1 MYH13	1.87e-03	18	67	2	IPR002928
Domain	CH	SPTB SPTBN1 MICAL3	2.03e-03	70	67	3	PF00307
Domain	Myosin-like_IQ_dom	MYH1 MYH13	2.08e-03	19	67	2	IPR027401
Domain	-	MYH1 MYH13	2.08e-03	19	67	2	4.10.270.10
Domain	-	SPTB SPTBN1 MICAL3	2.12e-03	71	67	3	1.10.418.10
Domain	CH	SPTB SPTBN1 MICAL3	2.29e-03	73	67	3	PS50021
Domain	CH-domain	SPTB SPTBN1 MICAL3	2.48e-03	75	67	3	IPR001715
Domain	Actinin_actin-bd_CS	SPTB SPTBN1	3.06e-03	23	67	2	IPR001589
Domain	Spectrin	SPTB SPTBN1	3.06e-03	23	67	2	PF00435
Domain	ACTININ_2	SPTB SPTBN1	3.06e-03	23	67	2	PS00020
Domain	ACTININ_1	SPTB SPTBN1	3.06e-03	23	67	2	PS00019
Domain	Myosin_head_motor_dom	MYH1 MYH13	8.20e-03	38	67	2	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH13	8.20e-03	38	67	2	PS51456
Domain	Myosin_head	MYH1 MYH13	8.20e-03	38	67	2	PF00063
Domain	MYSc	MYH1 MYH13	8.20e-03	38	67	2	SM00242
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DDX47 EZR RALA ATAD3B MAP7D3 TCERG1 RBM12B ATAD3A NUDT21 SPTBN1 ARPC1A PSMD3 EVPL LMNB2 PFKP ARCN1 NCOA5	4.51e-10	1257	71	17	36526897
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	EZR MYH1 RBM12B NUDT21 CHTF18 SPTBN1 ARPC1A IKBKG PSMD3 PFKP NEXN ARCN1	9.30e-10	538	71	12	28524877
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EZR RALA MYH1 ATAD3B MYH13 ATAD3A TRAPPC5 SPTBN1 PSMD3 CEP295 LMNB2 CFAP210 ARHGEF4 PFKP PICK1	1.76e-07	1442	71	15	35575683
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PTK2B RALA ATAD3B ATAD3A NUDT21 SPTB SPTBN1 ARPC1A SLC17A7 PSMD3 MICAL3 ARHGEF4 PFKP ARCN1	1.00e-06	1431	71	14	37142655
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DDX47 EZR RALA RBM12B ATAD3A NUDT21 ARPC1A PSMD3 LMNB2 PFKP ARCN1 NCOA5	1.03e-06	1024	71	12	24711643
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DDX47 ATAD3B TBC1D9B ATAD3A NUDT21 TRAPPC5 SPTBN1 IKBKG PSMD3 MICAL3 PFKP STX10 NEXN ARCN1	1.08e-06	1440	71	14	30833792
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	EZR RALA NSFL1C MAP7D3 TCERG1 ATAD3A SPTBN1 PSMD3 MICAL3 ARCN1	1.73e-06	708	71	10	39231216
Pubmed	ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.	ATAD3B ATAD3A	4.11e-06	2	71	2	18639545
Pubmed	Molecular characterization of the tumor-associated antigen AAA-TOB3.	ATAD3B ATAD3A	4.11e-06	2	71	2	16909202
Pubmed	The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.	ATAD3B ATAD3A	4.11e-06	2	71	2	17210950
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	EZR ATAD3A SPTBN1 PSMD3 EVPL LMNB2 PFKP	4.84e-06	327	71	7	31409639
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	DDX47 NSFL1C MAP7D3 ATAD3A SPTBN1 PSMD3 LMNB2 ARCN1 ZWINT	5.03e-06	624	71	9	33729478
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	RALA ATAD3A SPTBN1 ARPC1A PSMD3 LMNB2 ARCN1	5.56e-06	334	71	7	30425250
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	EZR ATAD3B ATAD3A SPTBN1 PSMD3 LMNB2 NEXN ARCN1	5.90e-06	477	71	8	31300519
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	EZR MYH1 TBC1D9B MYH13 ATAD3A SPTBN1 PSMD3 LMNB2 ARCN1	6.73e-06	647	71	9	26618866
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	DDX47 EZR RBM12B ATAD3A NUDT21 SPTBN1 EVPL LMNB2 NCOA5	7.16e-06	652	71	9	31180492
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	EZR RALA RBSN ATAD3B ELL2 ATAD3A DDHD1 SPTBN1 LMNB2 ARHGEF4 GRM8 ZNF365	7.46e-06	1242	71	12	30973865
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	EZR ATAD3B MYH13 TCERG1 ATAD3A RABGAP1L SPTBN1 PSMD3 PFKP ARCN1	8.40e-06	847	71	10	35235311
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PTK2B HAUS8 RBSN MAP7D3 TCERG1 RABGAP1L SPTBN1 ARHGEF4 PFKP MEX3B	9.69e-06	861	71	10	36931259
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	PTK2B DDHD1 SPTBN1 MICAL3	1.11e-05	67	71	4	29254152
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTB SPTBN1	1.23e-05	3	71	2	11294830
Pubmed	[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].	ATAD3B ATAD3A	1.23e-05	3	71	2	22192748
Pubmed	ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.	ATAD3B ATAD3A	1.23e-05	3	71	2	28549128
Pubmed	ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.	ATAD3B ATAD3A	1.23e-05	3	71	2	22664726
Pubmed	ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.	ATAD3B ATAD3A	1.23e-05	3	71	2	38923254
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	1.23e-05	3	71	2	8479293
Pubmed	ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.	ATAD3B ATAD3A	1.23e-05	3	71	2	34936866
Pubmed	Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.	ATAD3B ATAD3A	1.23e-05	3	71	2	25375035
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTB SPTBN1	1.23e-05	3	71	2	32425157
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	1.23e-05	3	71	2	1467942
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DDX47 SETD1B NSFL1C TCERG1 ATAD3A CHTF18 SPTBN1 PSMD3 LMNB2 PFKP NEXN ARCN1	1.75e-05	1353	71	12	29467282
Pubmed	ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.	ATAD3B ATAD3A	2.46e-05	4	71	2	35236834
Pubmed	Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.	ATAD3B ATAD3A	2.46e-05	4	71	2	36736924
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH13	2.46e-05	4	71	2	10388558
Pubmed	The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.	ATAD3B ATAD3A	2.46e-05	4	71	2	38250153
Pubmed	Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells.	ATAD3B ATAD3A	2.46e-05	4	71	2	29242539
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	2.46e-05	4	71	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	2.46e-05	4	71	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1	2.46e-05	4	71	2	21412925
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	2.46e-05	4	71	2	12820899
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DDX47 EZR RALA TCERG1 ATAD3A NUDT21 SPTBN1 ARPC1A PSMD3 LMNB2 ARCN1 NCOA5	2.92e-05	1425	71	12	30948266
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	NUDT21 SPTBN1 PSMD3 PFKP	4.06e-05	93	71	4	38245532
Pubmed	Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.	ATAD3B ATAD3A	4.09e-05	5	71	2	24239551
Pubmed	ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels.	ATAD3B ATAD3A	4.09e-05	5	71	2	29898916
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DDX47 ACP6 ATAD3B TCERG1 ATAD3A NUDT21 CHTF18 PSMD3 PFKP ARCN1 ZWINT	4.61e-05	1257	71	11	37317656
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	ATAD3B ATAD3A SPTB PFKP	4.98e-05	98	71	4	34943047
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	RBSN NSFL1C SPTB SPTBN1 MICAL3	5.33e-05	197	71	5	36604605
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	HAUS8 MAP7D3 CEP295 ZWINT	5.61e-05	101	71	4	24613305
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DDX47 EZR TCERG1 RBM12B ATAD3A SPTBN1 ARPC1A LMNB2	5.99e-05	660	71	8	32780723
Pubmed	The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.	PNMA5 PNMA6A	6.13e-05	6	71	2	16214224
Pubmed	Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.	ATAD3B ATAD3A	6.13e-05	6	71	2	31472450
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH13	6.13e-05	6	71	2	10077619
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	DDX47 TCERG1 SPTBN1 NCOA5	6.28e-05	104	71	4	26167872
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	ACP6 ATAD3B ATAD3A DDHD1	7.55e-05	109	71	4	29111324
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	DDX47 ATAD3B ATAD3A PSMD3 PFKP	8.05e-05	215	71	5	30462309
Pubmed	Identification of FBXO25-interacting proteins using an integrated proteomics approach.	ATAD3B ATAD3A PSMD3 PFKP	8.38e-05	112	71	4	20473970
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH13	8.57e-05	7	71	2	35210422
Pubmed	Structurally and functionally unique complexins at retinal ribbon synapses.	CPLX3 SLC17A7	8.57e-05	7	71	2	15911881
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SPTB SPTBN1 IKBKG EVPL MICAL3 LMNB2	9.59e-05	360	71	6	33111431
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	DDX47 EZR TCERG1 ATAD3A NUDT21 SPTBN1 PSMD3 PFKP	9.66e-05	707	71	8	19738201
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RALA RBSN ATAD3B NSFL1C ATAD3A RABGAP1L SPTBN1 PSMD3 ARCN1 ZWINT	1.03e-04	1139	71	10	36417873
Pubmed	Knockout mice with pituitary malformations help identify human cases of hypopituitarism.	EZR RALA SPTBN1	1.09e-04	45	71	3	38822427
Pubmed	Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.	SLC17A7 PICK1	1.14e-04	8	71	2	25047565
Pubmed	GSK-3β controls NF-kappaB activity via IKKγ/NEMO.	NSFL1C IKBKG	1.14e-04	8	71	2	27929056
Pubmed	ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.	ATAD3B ATAD3A	1.14e-04	8	71	2	30914652
Pubmed	p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO.	NSFL1C IKBKG	1.14e-04	8	71	2	22990857
Pubmed	Atad3 function is essential for early post-implantation development in the mouse.	ATAD3B ATAD3A	1.14e-04	8	71	2	23372768
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1B KMT2E	1.14e-04	8	71	2	23130995
Pubmed	Sublethal necroptosis signaling promotes inflammation and liver cancer.	MLKL IKBKG	1.14e-04	8	71	2	37329888
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	ATAD3B ATAD3A SPTB SPTBN1 ARPC1A	1.17e-04	233	71	5	29518331
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	SPTBN1 IKBKG PSMD3 NEXN ARCN1	1.22e-04	235	71	5	28378594
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	EZR ATAD3B ATAD3A SPTB WDR27 PSMD3 EVPL LMNB2	1.23e-04	732	71	8	34732716
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MYH1 DQX1 EVPL CEP295 LMNB2 PFKP ITPRIPL1 ARCN1	1.27e-04	736	71	8	29676528
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	DDX47 EZR MLKL TCERG1 ATAD3A NUDT21 CHTF18 SPTBN1 PSMD3 PFKP ARCN1	1.32e-04	1415	71	11	28515276
Pubmed	NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.	MLKL IKBKG	1.47e-04	9	71	2	27560715
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1	1.83e-04	10	71	2	22159418
Pubmed	Mor2, supernatant malate dehydrogenase, is linked to wa2 and Hba on mouse chromosome 11 in a region of homology with human chromosome 2p.	SPTBN1 GCK	1.83e-04	10	71	2	7698769
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DDX47 MLKL NUDT21 SPTBN1 PSMD3 PFKP ARCN1	1.87e-04	582	71	7	20467437
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	INTS10 ATAD3B MAP7D3 TCERG1 ATAD3A PSMD3	1.97e-04	411	71	6	35182466
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	EZR ATAD3B ATAD3A NUDT21 PSMD3 LMNB2 ARCN1 NCOA5	1.99e-04	786	71	8	29128334
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTB SPTBN1	2.23e-04	11	71	2	17607528
Pubmed	Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast.	ATAD3B ATAD3A	2.23e-04	11	71	2	36000457
Pubmed	FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.	ATAD3B ATAD3A	2.23e-04	11	71	2	37279268
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	DDX47 EZR NSFL1C ARPC1A PSMD3 LMNB2 PFKP ARCN1	2.30e-04	803	71	8	36517590
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	EZR RALA ATAD3B ATAD3A SPTBN1 PSMD3 LMNB2	2.34e-04	604	71	7	37616343
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DDX47 EZR TCERG1 RBM12B NUDT21 SPTBN1 MEX3B NCOA5	2.38e-04	807	71	8	22681889
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	ATAD3B ATAD3A SPTBN1 PFKP	2.39e-04	147	71	4	16959763
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	EZR ATAD3A NUDT21 SPTBN1 LMNB2 PFKP ARCN1	2.41e-04	607	71	7	39147351
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	RBSN SPTBN1 CEP295 ZNF365	2.65e-04	151	71	4	17043677
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PTK2B ATAD3B ATAD3A SPTBN1 ARPC1A	2.80e-04	281	71	5	28706196
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	ATAD3A SPTBN1 PFKP	2.97e-04	63	71	3	37052853
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTB SPTBN1	3.16e-04	13	71	2	18796539
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	EZR ATAD3B ATAD3A PSMD3 PFKP NEXN	3.23e-04	451	71	6	36168627
Pubmed	Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.	EZR PFKP ARCN1	3.25e-04	65	71	3	34645483
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	TCERG1 ATAD3A NUDT21 SPTBN1 PSMD3 LMNB2 ARCN1	3.26e-04	638	71	7	33239621
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	ATAD3B NSFL1C MAP7D3 TCERG1 ATAD3A SPTBN1 ZWINT	3.29e-04	639	71	7	23443559
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DDX47 EZR TCERG1 RBM12B ATAD3A NUDT21 SPTBN1 LMNB2 NCOA5	3.49e-04	1082	71	9	38697112
Pubmed	IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death.	MLKL IKBKG	3.68e-04	14	71	2	37085671
Pubmed	Large-scale phosphorylation analysis of mouse liver.	NSFL1C RABGAP1L	3.68e-04	14	71	2	17242355
Pubmed	Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.	MLKL IKBKG	3.68e-04	14	71	2	31519886
Interaction	CCDC14 interactions	HAUS8 IKBKG CEP295 KIFC3 CCDC183 ZWINT	5.74e-06	129	70	6	int:CCDC14
Cytoband	2p13.1	DQX1 LBX2	1.28e-03	34	71	2	2p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	HAUS8 TRAPPC5 LMNB2 HCN2 STX10 HMG20B	1.48e-03	797	71	6	chr19p13
Cytoband	Xq28	PNMA5 IKBKG PNMA6A	2.61e-03	176	71	3	Xq28
Cytoband	17q21.32	TTLL6 EFCAB13	2.65e-03	49	71	2	17q21.32
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	PNMA5 IKBKG PNMA6A	4.46e-03	213	71	3	chrXq28
Cytoband	19p13.3	LMNB2 HCN2 HMG20B	6.00e-03	237	71	3	19p13.3
Cytoband	1p36.33	ATAD3B ATAD3A	6.40e-03	77	71	2	1p36.33
GeneFamily	EF-hand domain containing\|Spectrins	SPTB SPTBN1	1.50e-04	7	49	2	1113
GeneFamily	Paraneoplastic Ma antigens	PNMA5 PNMA6A	3.90e-04	11	49	2	671
GeneFamily	AAA ATPases	ATAD3B ATAD3A CHTF18	3.98e-04	53	49	3	413
GeneFamily	Myosin heavy chains	MYH1 MYH13	7.39e-04	15	49	2	1098
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B KMT2E	3.82e-03	34	49	2	487
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EZR PTK2B	8.11e-03	50	49	2	1293
ToppCell	Ionocyte\|World / shred by cell class for turbinate	RALA SPTB PNMA6A MEX3B NMU	6.68e-06	165	71	5	0cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RBSN SULT1C2 EVPL DCST2 NMU	8.65e-06	174	71	5	2a96a4fd7d9ef05213b26103c689cf3a26968713
ToppCell	BAL-Control-cDC_1\|Control / Compartment, Disease Groups and Clusters	RABGAP1L EFCAB13 EVPL NEXN NMU	9.40e-06	177	71	5	aa021f6d62e9d740c5ea499faaf875de835a2865
Disease	mood instability measurement	RABGAP1L LMNB2 GRM8 ZWINT NCOA5	1.11e-05	128	67	5	EFO_0008475
Disease	neutrophil gelatinase-associated lipocalin measurement	ELL2 PSMD3	1.52e-05	3	67	2	EFO_0021964
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3A	3.04e-05	4	67	2	DOID:440 (implicated_via_orthology)
Disease	triglyceride measurement, coronary artery disease	SETD1B GCK	3.04e-05	4	67	2	EFO_0001645, EFO_0004530
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTB SPTBN1	3.04e-05	4	67	2	DOID:0050882 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH13 LMNB2	1.80e-04	48	67	3	DOID:423 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH13	2.26e-04	10	67	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH13	3.30e-04	12	67	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH13	3.30e-04	12	67	2	DOID:2106 (implicated_via_orthology)
Disease	insomnia, total blood protein measurement	RBSN NPIPB8 DDHD1 ZWINT	3.64e-04	148	67	4	EFO_0004536, EFO_0004698
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH13	3.90e-04	13	67	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH13	5.23e-04	15	67	2	DOID:0050646 (implicated_via_orthology)
Disease	syndrome (implicated_via_orthology)	ATAD3B ATAD3A	7.59e-04	18	67	2	DOID:225 (implicated_via_orthology)
Disease	interleukin-6 measurement	EFCAB13 KMT2E GRM8	2.14e-03	112	67	3	EFO_0004810
Disease	L-Selectin measurement	PSMD3 EVPL	2.26e-03	31	67	2	EFO_0008202
Disease	fatty liver disease (implicated_via_orthology)	IKBKG GCK	2.26e-03	31	67	2	DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKMRRAEASARVENS	CHTF18	851	Q8WVB6
ERVAEAQRFARMELR	DDX47	401	Q9H0S4
RMETVARRFIKLDAQ	ELL2	561	O00472
FDEVVKQMVAAFERR	COQ10B	201	Q9H8M1
KNEMLRVEAEARARA	ATAD3A	231	Q9NVI7
VRQCRKRADMFSEEQ	ARHGEF4	311	Q9NR80
ERFRNMDKRATTEDR	ARPC1A	301	Q92747
EEQAMKAERLNRRRF	RBM12B	451	Q8IXT5
RANVDKVFFDLMREI	RALA	161	P11233
EEMERKRAVERQAAL	RBSN	391	Q9H1K0
RDAIKRRGDFEMDVV	GCK	186	P35557
VKEDFRLAMERQVSR	INTS10	671	Q9NVR2
EEKRAFEEARRQMVN	NEXN	276	Q0ZGT2
RFEQMAKAREEEEQR	NEXN	516	Q0ZGT2
SAEAKELAEERMRAR	MICAL3	1586	Q7RTP6
ERRMKRFRVDEEFQS	NMU	136	P48645
RELEEAMAGERDKFR	LMNB2	336	Q03252
DVQKAMDERRFQDAV	PFKP	366	Q01813
REEIARQAAKMADEA	NCOA5	306	Q9HCD5
RLQMEEDAARRKQAE	EVPL	1096	Q92817
KMFQRAQELRRRAED	NPIPB8	201	E9PQR5
REERKMEAILQAFAR	KMT2E	576	Q8IZD2
AALRMERQAASEEKR	IKBKG	211	Q9Y6K9
REAEFQKMRRDLEEA	MYH1	1171	P12882
EAERKAAEAARMGRR	nan	91	B2RBV5
KRDVEEMRADVASLR	LBX2	141	Q6XYB7
MAAERQEALREFVAV	NSFL1C	1	Q9UNZ2
VKMENNLAEFERRAE	HAUS8	161	Q9BT25
RAVIMFANEDDIRRI	GRM8	276	O00222
RAFQMLRRDNEKIEA	MLKL	146	Q8NB16
RAVQAVYEDMDARKV	DQX1	306	Q8TE96
KRYRAEENARRLMEQ	RABGAP1L	761	Q5R372
EMEFEERKRAAEQRQ	ITPRIPL1	56	Q6GPH6
MERDAQFTQRKAERA	CPLX3	56	Q8WVH0
VKRNMRQREASFIEE	CCDC183	221	Q5T5S1
EEFAKVVRNMRDAAR	EFCAB13	656	Q8IY85
ARMVAAANEIAKERR	MAP7D3	21	Q8IWC1
AERLEADRMAALRAK	EZR	386	P15311
EVADRVRKFFRSIMD	DCST2	161	Q5T1A1
MREAARKIEERHFSN	DDHD1	431	Q8NEL9
KDSSVAARFQRMREE	NUDT21	56	O43809
AARFQRMREEFDKIG	NUDT21	61	O43809
EKDIAMEQERNARYR	PTK2B	686	Q14289
QERMERFEKAHVRGF	CEP295	231	Q9C0D2
RMFGSQKAVEREQER	HCN2	181	Q9UL51
KMFQRAQELRRRAED	NPIPB6	201	E9PJ23
AVRETQEREAKAEMR	ARCN1	146	P48444
AELRRLRKMNVAFEE	HMG20B	201	Q9P0W2
RKEDVAMARREIISA	MEX3B	116	Q6ZN04
VQRLRQMEKEEEFRA	IQCA1L	261	A6NCM1
RAIEEAFARAQVEMK	KIFC3	341	Q9BVG8
NRKMVEVVAFRAFDE	SETD1B	881	Q9UPS6
MEFRQEEFRKLAGRA	SLC17A7	1	Q9P2U7
MEKEALARASADRVR	PNMA6A	271	P0CW24
EQLARRFDRKAAMRE	SPTBN1	421	Q01082
SLRAEDIEQMRFKQR	TBC1D9B	776	Q66K14
MLRVETEARARAKAE	ATAD3B	186	Q5T9A4
LSRVMKERDAQIEFR	CFAP210	161	Q0VFZ6
VLGRMFRREDNAKAV	PNMA5	51	Q96PV4
AEERRRDFLQMVLDA	TBXAS1	271	P24557
MEEAQRKRTQLREAF	ZWINT	121	O95229
VREKFNRMVEAVDRT	ZNF365	161	Q70YC5
RREREQQDLEFAKEM	PSMD3	511	O43242
EAAMEAEIKAARERA	TCERG1	641	O14776
QERKVFVERMREAVQ	STX10	86	O60499
VAQNERFDEIYRRKM	SULT1C2	271	O00338
REAEFQKMRRDLEEA	MYH13	1171	Q9UKX3
KRFARMIEQRAVDTS	ACP6	271	Q9NPH0
EQLARRFDRKAAMRE	SPTB	421	P11277
MEQRLAEFRAARKRA	SAYSD1	1	Q9NPB0
REMRIEEAKGFRAVQ	TTLL6	416	Q8N841
AASEQRRAARNVMKD	WDR27	431	A2RRH5
RQEARARFSQMRKDV	PICK1	301	Q9NRD5
MIKFEEAVIARDRAL	TRAPPC5	171	Q8IUR0