Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cyclosporin A binding	RANBP2 PPIA PPIB PPIF	3.56e-07	24	50	4	GO:0016018
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RANBP2 PPIA PPIB PPIF	7.36e-06	50	50	4	GO:0003755
GeneOntologyMolecularFunction	cis-trans isomerase activity	RANBP2 PPIA PPIB PPIF	9.30e-06	53	50	4	GO:0016859
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP44 USP8 PAN2 USP15	1.90e-04	114	50	4	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP44 USP8 PAN2 USP15	2.62e-04	124	50	4	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP44 USP8 PAN2 USP15	3.82e-04	137	50	4	GO:0019783
GeneOntologyMolecularFunction	aminoacyl-tRNA editing activity	IARS2 LARS1	5.49e-04	14	50	2	GO:0002161
GeneOntologyMolecularFunction	amide binding	RANBP2 ACBD5 PPIA PPIB PPIF	8.89e-04	299	50	5	GO:0033218
GeneOntologyMolecularFunction	collagen binding	AEBP1 ITGA1 PPIB	1.10e-03	81	50	3	GO:0005518
GeneOntologyMolecularFunction	peptidase activity	USP44 USP8 AEBP1 PSMB3 PAN2 USP15 YME1L1	1.15e-03	654	50	7	GO:0008233
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP8 USP15	1.25e-03	21	50	2	GO:1990380
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP44 USP8 PAN2 USP15	1.35e-03	192	50	4	GO:0008234
GeneOntologyMolecularFunction	isomerase activity	RANBP2 PPIA PPIB PPIF	1.35e-03	192	50	4	GO:0016853
GeneOntologyMolecularFunction	actin filament binding	VIL1 MYH13 TLN1 PICK1	2.49e-03	227	50	4	GO:0051015
GeneOntologyBiologicalProcess	protein peptidyl-prolyl isomerization	RANBP2 PPIA PPIB PPIF	2.30e-06	38	51	4	GO:0000413
GeneOntologyBiologicalProcess	peptidyl-proline modification	RANBP2 PPIA PPIB PPIF	9.57e-06	54	51	4	GO:0018208
GeneOntologyBiologicalProcess	post-translational protein modification	USP44 USP8 RANBP2 MYCBP2 ABCB11 CUL9 IFT80 RNF128 PPIA USP15 PPIB	5.05e-05	1074	51	11	GO:0043687
GeneOntologyBiologicalProcess	cellular response to starvation	MYH13 LARS1 IFI16 YME1L1 PICK1	9.25e-05	185	51	5	GO:0009267
GeneOntologyBiologicalProcess	protein maturation	RANBP2 AEBP1 RP2 IFI16 PPIA PPIB YME1L1 PPIF	1.28e-04	619	51	8	GO:0051604
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP44 USP8 RANBP2 MYCBP2 ABCB11 CUL9 IFT80 RNF128 PPIA USP15	1.54e-04	1009	51	10	GO:0070647
Domain	Cyclophilin-type_PPIase_CS	RANBP2 PPIA PPIB PPIF	1.71e-07	19	50	4	IPR020892
Domain	Cyclophilin-like_dom	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	IPR029000
Domain	CSA_PPIASE_2	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	PS50072
Domain	Pro_isomerase	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	PF00160
Domain	-	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	2.40.100.10
Domain	Cyclophilin-type_PPIase_dom	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	IPR002130
Domain	CSA_PPIASE_1	RANBP2 PPIA PPIB PPIF	3.21e-07	22	50	4	PS00170
Domain	Cyclophilin-type_PPIase	PPIA PPIB PPIF	2.32e-05	21	50	3	IPR024936
Domain	UCH	USP44 USP8 PAN2 USP15	3.87e-05	71	50	4	PF00443
Domain	USP_3	USP44 USP8 PAN2 USP15	4.09e-05	72	50	4	PS50235
Domain	USP_dom	USP44 USP8 PAN2 USP15	4.09e-05	72	50	4	IPR028889
Domain	Peptidase_C19_UCH	USP44 USP8 PAN2 USP15	4.09e-05	72	50	4	IPR001394
Domain	Val/Leu/Ile-tRNA-synth_edit	IARS2 LARS1	1.05e-04	6	50	2	IPR009008
Domain	Anticodon_1	IARS2 LARS1	1.05e-04	6	50	2	PF08264
Domain	M/V/L/I-tRNA-synth_anticd-bd	IARS2 LARS1	1.05e-04	6	50	2	IPR013155
Domain	-	IARS2 LARS1	1.05e-04	6	50	2	3.90.740.10
Domain	aa-tRNA-synth_Ia	IARS2 LARS1	1.46e-04	7	50	2	IPR002300
Domain	APC_su10/DOC_dom	MYCBP2 CUL9	1.46e-04	7	50	2	IPR004939
Domain	DOC	MYCBP2 CUL9	1.46e-04	7	50	2	PS51284
Domain	tRNA-synt_1	IARS2 LARS1	1.46e-04	7	50	2	PF00133
Domain	APC10	MYCBP2 CUL9	1.46e-04	7	50	2	SM01337
Domain	ANAPC10	MYCBP2 CUL9	1.46e-04	7	50	2	PF03256
Domain	rSAM	TYW1B ELP3	2.50e-04	9	50	2	IPR007197
Domain	Radical_SAM	TYW1B ELP3	2.50e-04	9	50	2	PF04055
Domain	-	IARS2 LARS1	3.80e-04	11	50	2	1.10.730.10
Domain	tRNAsynth_Ia_anticodon-bd	IARS2 LARS1	7.21e-04	15	50	2	IPR009080
Domain	USP_CS	USP44 USP8 USP15	7.34e-04	66	50	3	IPR018200
Domain	USP_1	USP44 USP8 USP15	8.71e-04	70	50	3	PS00972
Domain	USP_2	USP44 USP8 USP15	9.08e-04	71	50	3	PS00973
Domain	-	AEBP1 MYCBP2 CUL9	9.84e-04	73	50	3	2.60.120.260
Domain	aa-tRNA-synth_I_CS	IARS2 LARS1	1.05e-03	18	50	2	IPR001412
Domain	AA_TRNA_LIGASE_I	IARS2 LARS1	1.17e-03	19	50	2	PS00178
Domain	RHOD	USP8 TBCK	1.57e-03	22	50	2	SM00450
Domain	RHODANESE_3	USP8 TBCK	1.71e-03	23	50	2	PS50206
Domain	Rhodanese-like_dom	USP8 TBCK	1.87e-03	24	50	2	IPR001763
Domain	Rhodanese	USP8 TBCK	1.87e-03	24	50	2	PF00581
Domain	-	USP8 TBCK	1.87e-03	24	50	2	3.40.250.10
Domain	Galactose-bd-like	AEBP1 MYCBP2 CUL9	2.04e-03	94	50	3	IPR008979
Pubmed	Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.	RANBP2 PPIA PPIB PPIF	5.53e-09	15	51	4	20676357
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RANBP2 UPF2 MYCBP2 TLN1 PSMB3 LARS1 NHP2 ELP3 IFI16 PPIA PPIB YME1L1 PHGDH HIRA	5.71e-09	1353	51	14	29467282
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	VIL1 ATP6V1B1 MYH13 TLN1 PSMB3 ABCB11 RP2 ITGA1 PPIA PPIB PHGDH SERPINA7	2.01e-08	1016	51	12	19056867
Pubmed	Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.	SEPTIN5 HIRA TBX5	1.04e-07	7	51	3	16684884
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	RANBP2 TLN1 ACBD5 LARS1 PPIA PPIB YME1L1 NNT	1.77e-07	422	51	8	27342126
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RANBP2 MYCBP2 BBS7 TLN1 LARS1 RP2 PPIA PPIB NNT PHGDH	2.00e-06	1024	51	10	24711643
Pubmed	A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation.	PPIA PPIB	2.11e-06	2	51	2	21057089
Pubmed	Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.	PPIA PPIB	2.11e-06	2	51	2	8513493
Pubmed	Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.	PPIA PPIB	2.11e-06	2	51	2	32162654
Pubmed	Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.	PPIA PPIB	2.11e-06	2	51	2	31634494
Pubmed	The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.	PPIA PPIB	2.11e-06	2	51	2	9032343
Pubmed	alpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteins.	TLN1 ITGA1	2.11e-06	2	51	2	11336656
Pubmed	Functional aspects of extracellular cyclophilins.	PPIA PPIB	2.11e-06	2	51	2	24713575
Pubmed	Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies.	PPIA PPIB	2.11e-06	2	51	2	7829860
Pubmed	Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24.	PPIA PPIB	2.11e-06	2	51	2	10096576
Pubmed	Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B.	PPIA PPIB	2.11e-06	2	51	2	19297321
Pubmed	Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model.	PPIA PPIB	2.11e-06	2	51	2	38427624
Pubmed	Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain.	PPIA PPIB	2.11e-06	2	51	2	10026140
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	IARS2 MYCBP2 TLN1 PSMB3 LARS1 PPIA PPIB NNT PHGDH	2.37e-06	807	51	9	30575818
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	RANBP2 MRPL21 TBCK PSMB3 LARS1 IFT80 ELP3 PPIA USP15 YME1L1 PHGDH	2.97e-06	1335	51	11	29229926
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP44 USP8 PAN2 USP15	6.28e-06	81	51	4	12838346
Pubmed	Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.	PPIA PPIB	6.32e-06	3	51	2	1618811
Pubmed	CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.	PPIA PPIB	6.32e-06	3	51	2	20147391
Pubmed	Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells.	PPIA PPIB	6.32e-06	3	51	2	19503092
Pubmed	An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney.	PPIA PPIB	6.32e-06	3	51	2	8203464
Pubmed	The V3 loop of human immunodeficiency virus type-1 envelope protein is a high-affinity ligand for immunophilins present in human blood.	PPIA PPIB	6.32e-06	3	51	2	9546659
Pubmed	Two isoforms of otubain 1 regulate T cell anergy via GRAIL.	USP8 RNF128	6.32e-06	3	51	2	14661020
Pubmed	Variations of sequences and amino acid compositions of proteins that sustain their biological functions: An analysis of the cyclophilin family of proteins.	PPIA PPIB	6.32e-06	3	51	2	10545201
Pubmed	A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor.	PPIA PPIB	6.32e-06	3	51	2	22205628
Pubmed	Immunophilins and HIV-1 infection.	PPIA PPIB	6.32e-06	3	51	2	12181673
Pubmed	Defining the membrane proteome of NK cells.	RANBP2 MYCBP2 ACBD5 ITGA1 TUBGCP4 IFI16 PPIA PPIB YME1L1 NNT	6.41e-06	1168	51	10	19946888
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	PDE6B BBS7 CNGB3 RP2	8.34e-06	87	51	4	20801516
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RANBP2 IARS2 MYCBP2 PSMB3 LARS1 ELP3 PPIA USP15 YME1L1 PHGDH	1.22e-05	1257	51	10	37317656
Pubmed	HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.	RANBP2 PPIA	1.26e-05	4	51	2	22174692
Pubmed	p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.	IFI16 TBX5	1.26e-05	4	51	2	16556595
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	USP8 MYCBP2 BBS7 LARS1 PAN2 RP2 IFT80 TUBGCP4 USP15 YME1L1	1.86e-05	1321	51	10	27173435
Pubmed	A model for cofactor use during HIV-1 reverse transcription and nuclear entry.	RANBP2 PPIA	2.10e-05	5	51	2	24525292
Pubmed	Functional constraints on HIV-1 capsid: their impacts on the viral immune escape potency.	RANBP2 PPIA	2.10e-05	5	51	2	23087682
Pubmed	HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.	RANBP2 PPIA	2.10e-05	5	51	2	26109731
Pubmed	TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.	SEPTIN5 HIRA	3.15e-05	6	51	2	11239417
Pubmed	HIV: Slipping under the radar.	RANBP2 PPIA	3.15e-05	6	51	2	24196714
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RANBP2 IARS2 MRPL21 LARS1 CUL9 NHP2 ELP3 HIRA	3.28e-05	857	51	8	25609649
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	RANBP2 IARS2 LARS1 CUL9 RP2 PPIA NNT PPIF	3.34e-05	859	51	8	31536960
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	RANBP2 IARS2 TLN1 PSMB3 LARS1 TUBGCP4 IFI16 PHGDH GFM2 HIRA	3.89e-05	1440	51	10	30833792
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	ATP6V1B1 IARS2 TLN1 LARS1 PPIA USP15 NNT PHGDH	3.89e-05	878	51	8	37223481
Pubmed	A comprehensive analysis of 22q11 gene expression in the developing and adult brain.	SEPTIN5 HIRA TBX5	4.04e-05	45	51	3	14614146
Pubmed	SHARPIN is an endogenous inhibitor of β1-integrin activation.	TLN1 ITGA1	4.41e-05	7	51	2	21947080
Pubmed	New insights in the role of nucleoporins: a bridge leading to concerted steps from HIV-1 nuclear entry until integration.	RANBP2 PPIA	4.41e-05	7	51	2	24051001
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	IARS2 MRPL21 UPF2 MYCBP2 PSMB3 ACBD5 YME1L1 NNT GFM2 PPIF	5.36e-05	1496	51	10	32877691
Pubmed	Roles of HIV-1 capsid in viral replication and immune evasion.	RANBP2 PPIA	5.87e-05	8	51	2	25036886
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	USP8 RANBP2 IARS2 TLN1 PSMB3 LARS1 PPIA PHGDH	6.01e-05	934	51	8	33916271
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	RANBP2 IARS2 TLN1 LARS1 PPIA PPIB	6.89e-05	477	51	6	31300519
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	RANBP2 TLN1 LARS1 NHP2 PPIA YME1L1 PHGDH	7.03e-05	701	51	7	30196744
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	TLN1 PSMB3 LARS1 NHP2 PPIA USP15 PHGDH	7.41e-05	707	51	7	19738201
Pubmed	HIV-1 evades innate immune recognition through specific cofactor recruitment.	RANBP2 PPIA	7.54e-05	9	51	2	24196705
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	VIL1 RANBP2 TLN1 NHP2 PPIB PHGDH GFM2	7.68e-05	711	51	7	33022573
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RANBP2 UPF2 MYCBP2 TLN1 PPIB NNT HIRA	8.60e-05	724	51	7	36232890
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP44 USP8 MYCBP2 PSMB3 PAN2 NHP2 USP15 PPIB	1.00e-04	1005	51	8	19615732
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	IARS2 MRPL21 ZER1 TUBGCP4 YME1L1 PPIF	1.05e-04	515	51	6	31617661
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	UPF2 TLN1 PSMB3 LARS1 PPIA PHGDH	1.33e-04	538	51	6	28524877
Pubmed	The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.	RNF128 PPIA PPIB	1.33e-04	67	51	3	22046132
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	RANBP2 IFI16 PHGDH HIRA	1.37e-04	178	51	4	27637333
Pubmed	Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.	SEPTIN5 HIRA	1.38e-04	12	51	2	9383280
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RANBP2 IARS2 TLN1 PSMB3 NHP2 PPIB NNT PHGDH PPIF	1.49e-04	1367	51	9	32687490
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RANBP2 UPF2 MYCBP2 PAN2 PPIA PPIB PHGDH HIRA	1.66e-04	1082	51	8	38697112
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	TLN1 PSMB3 RP2 PPIA PPIB PHGDH	1.73e-04	565	51	6	20458337
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	USP8 IARS2 MYCBP2 TLN1	1.76e-04	190	51	4	15161933
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	RANBP2 PSMB3 LARS1 NHP2 USP15 PHGDH	1.84e-04	571	51	6	37167062
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	RANBP2 MYCBP2 TLN1 PSMB3 LARS1 IFI16 PPIB PHGDH	1.89e-04	1103	51	8	34189442
Pubmed	Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis.	FREM3 TBX5	1.90e-04	14	51	2	25245104
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	USP8 RANBP2 TLN1 LARS1 NHP2 ELP3 PPIA PPIB PHGDH	1.94e-04	1415	51	9	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RANBP2 IARS2 TLN1 LARS1 NHP2 PPIA PPIB NNT PHGDH	2.04e-04	1425	51	9	30948266
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP8 USP15	2.19e-04	15	51	2	9827704
Pubmed	The BBSome controls IFT assembly and turnaround in cilia.	BBS7 IFT80	2.19e-04	15	51	2	22922713
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RANBP2 MYCBP2 TLN1 PSMB3 LARS1 PPIA PPIB PHGDH	2.50e-04	1149	51	8	35446349
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	RANBP2 IARS2 TLN1 LARS1 PPIB NNT	2.55e-04	607	51	6	39147351
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	MYCBP2 PAN2 CUL9 YME1L1	2.68e-04	212	51	4	33853758
Pubmed	The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.	PPIA USP15 PPIB	2.79e-04	86	51	3	26885983
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IARS2 MRPL21 MYCBP2 BBS7 TLN1 ACBD5 IFT80 PPIB YME1L1	2.80e-04	1487	51	9	33957083
Pubmed	Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.	COL19A1 TBX5	2.83e-04	17	51	2	25356765
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	RANBP2 IARS2 TLN1 USP15	2.88e-04	216	51	4	31519766
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	TLN1 LARS1 PPIA PPIB PHGDH	2.88e-04	397	51	5	21319273
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RANBP2 TLN1 LARS1 USP15 PHGDH	2.95e-04	399	51	5	37536630
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	VIL1 RANBP2 NHP2 PPIA PHGDH HIRA	3.01e-04	626	51	6	33644029
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM3 PICK1	3.18e-04	18	51	2	14730302
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	RANBP2 PSMB3 TUBGCP4 USP15 PHGDH	3.27e-04	408	51	5	33766124
Pubmed	Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.	SEPTIN5 HIRA	3.55e-04	19	51	2	19805316
Pubmed	Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner.	RANBP2 PPIA	3.55e-04	19	51	2	32545337
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	ATP6V1B1 AEBP1 PPIA PPIB PHGDH	3.61e-04	417	51	5	19199708
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RANBP2 IARS2 MYCBP2 TLN1 CUL9 NNT	3.76e-04	653	51	6	22586326
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	PDE6B BBS7 CNGB3 RP2	3.83e-04	233	51	4	32290105
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	RANBP2 PSMB3 TUBGCP4 PPIA USP15 PHGDH	3.89e-04	657	51	6	36180527
Pubmed	Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.	SEPTIN5 HIRA	3.94e-04	20	51	2	9740669
Pubmed	The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution.	COL19A1 RNF128	3.94e-04	20	51	2	31118233
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	RANBP2 LARS1 PPIA PPIF	4.09e-04	237	51	4	29564676
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	TLN1 IFI16 PPIA PPIB	4.22e-04	239	51	4	26641092
Pubmed	Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.	TLN1 PPIA	4.35e-04	21	51	2	6457647
Pubmed	USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.	MYCBP2 USP15	4.35e-04	21	51	2	32839293
Pubmed	Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.	IARS2 MRPL21 PPIA	4.60e-04	102	51	3	31722399
Pubmed	Smooth muscle contraction and relaxation.	TLN1 ITGA1	4.78e-04	22	51	2	14627618
Interaction	IGKV2-40 interactions	PAN2 IFI16 PHGDH	3.31e-06	12	51	3	int:IGKV2-40
Interaction	SVIL interactions	VIL1 MYH13 MYCBP2 TBCK PAN2 IFI16	2.61e-05	233	51	6	int:SVIL
Interaction	ATP5F1A interactions	RANBP2 PAN2 IFI16 USP15 YME1L1 NNT PHGDH PPIF TBX5	2.87e-05	640	51	9	int:ATP5F1A
Interaction	CTNNB1 interactions	USP8 RANBP2 TLN1 LARS1 PAN2 RNF128 PPIA USP15 NNT PHGDH PICK1	3.53e-05	1009	51	11	int:CTNNB1
Interaction	SERBP1 interactions	ATP6V1B1 IARS2 UPF2 TLN1 LARS1 PAN2 NHP2 IFI16 PPIA USP15 NNT PHGDH PICK1	4.14e-05	1432	51	13	int:SERBP1
Interaction	EFTUD2 interactions	USP8 RANBP2 TLN1 LARS1 PAN2 CUL9 NHP2 ELP3 IFI16 PPIA PPIB PHGDH TBX5	4.69e-05	1449	51	13	int:EFTUD2
Interaction	FHOD1 interactions	RANBP2 BBS7 PPIA PICK1	4.99e-05	80	51	4	int:FHOD1
Interaction	DNAJA2 interactions	IARS2 BBS7 ACBD5 PAN2 ELP3 USP15 HIRA TBX5	5.98e-05	542	51	8	int:DNAJA2
Interaction	ID1 interactions	USP8 IFI16 USP15 PHGDH	7.58e-05	89	51	4	int:ID1
Interaction	HUWE1 interactions	RANBP2 MYCBP2 PSMB3 LARS1 RP2 NHP2 IFI16 PPIA USP15 NNT PHGDH	8.38e-05	1110	51	11	int:HUWE1
Interaction	NUP58 interactions	RANBP2 ACBD5 IFI16 TBX5	8.62e-05	92	51	4	int:NUP58
Interaction	CHMP5 interactions	USP8 ATP6V1B1 PPIA TBX5	9.00e-05	93	51	4	int:CHMP5
Interaction	SURF1 interactions	IARS2 MRPL21 YME1L1 NNT PPIF	1.06e-04	186	51	5	int:SURF1
Interaction	SNRPA1 interactions	RANBP2 CNGB3 PSMB3 IFI16 PICK1 TBX5	1.06e-04	300	51	6	int:SNRPA1
Interaction	PABPC4 interactions	TLN1 LARS1 PAN2 CUL9 IFI16 PPIA PHGDH	1.17e-04	442	51	7	int:PABPC4
Interaction	STK33 interactions	TLN1 USP15 YME1L1	1.21e-04	38	51	3	int:STK33
Interaction	ATG16L1 interactions	RANBP2 MYCBP2 BBS7 TLN1 LARS1 PAN2 NHP2 PPIA PPIB YME1L1 PHGDH	1.25e-04	1161	51	11	int:ATG16L1
Interaction	BASP1 interactions	UPF2 TBCK PAN2 PPIA USP15 PPIB	1.27e-04	310	51	6	int:BASP1
Interaction	MRPL53 interactions	USP44 MRPL21 PPIB GFM2 PPIF	1.35e-04	196	51	5	int:MRPL53
Interaction	ERF interactions	BBS7 PAN2 PPIA SERPINA7	1.44e-04	105	51	4	int:ERF
Interaction	SOX2 interactions	USP44 ATP6V1B1 RANBP2 PSMB3 LARS1 ZBTB5 CUL9 NHP2 PPIA USP15 PHGDH HIRA	1.75e-04	1422	51	12	int:SOX2
Interaction	WDR36 interactions	BBS7 RP2 ELP3 IFI16 PPIA	1.78e-04	208	51	5	int:WDR36
Interaction	CHMP1B interactions	USP8 ATP6V1B1 PICK1	2.01e-04	45	51	3	int:CHMP1B
Interaction	PSMC5 interactions	USP44 TLN1 PSMB3 PAN2 PPIA USP15 TBX5	2.05e-04	484	51	7	int:PSMC5
Interaction	HSPD1 interactions	RANBP2 IARS2 MRPL21 LARS1 PAN2 ITGA1 IFI16 NNT PHGDH PPIF	2.06e-04	1022	51	10	int:HSPD1
Interaction	PSME3IP1 interactions	IARS2 PSMB3 PPIA GFM2	2.11e-04	116	51	4	int:PSME3IP1
Interaction	CCDC8 interactions	RANBP2 MYCBP2 BBS7 LARS1 CUL9 RP2 NNT PHGDH	2.23e-04	656	51	8	int:CCDC8
Interaction	COX15 interactions	IARS2 MRPL21 NHP2 PPIA YME1L1 NNT	2.53e-04	352	51	6	int:COX15
Interaction	SMARCC2 interactions	UPF2 MYCBP2 IFI16 USP15 HIRA TBX5	2.56e-04	353	51	6	int:SMARCC2
Interaction	TMEM70 interactions	IARS2 MRPL21 YME1L1 NNT PPIF	2.57e-04	225	51	5	int:TMEM70
Interaction	MRPL50 interactions	ATP6V1B1 MRPL21 TLN1 NHP2 GFM2	3.01e-04	233	51	5	int:MRPL50
Interaction	MOB3C interactions	RANBP2 TLN1 LARS1 USP15 PHGDH PICK1	3.02e-04	364	51	6	int:MOB3C
Interaction	RAE1 interactions	RANBP2 MYCBP2 IFI16 USP15 TBX5	3.20e-04	236	51	5	int:RAE1
Interaction	LZTFL1 interactions	BBS7 USP15 PICK1	3.27e-04	53	51	3	int:LZTFL1
GeneFamily	Cyclophilin peptidylprolyl isomerases	RANBP2 PPIA PPIB PPIF	6.28e-08	19	38	4	909
GeneFamily	Ubiquitin specific peptidases	USP44 USP8 PAN2 USP15	5.63e-06	56	38	4	366
GeneFamily	Aminoacyl tRNA synthetases, Class I	IARS2 LARS1	7.19e-04	19	38	2	131
Coexpression	HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN	PSMB3 ZBTB5 ZER1 PHGDH	1.06e-05	70	51	4	M13658
Drug	trioxazine	LARS1 PPIA PPIB PPIF	3.22e-07	26	51	4	CID000012478
Drug	Meala-csa	PPIA PPIB PPIF	1.26e-06	10	51	3	CID006436248
Drug	Proline	IARS2 LARS1 PPIA PPIB NNT PPIF	1.76e-06	164	51	6	CID000000614
Drug	AC1NRACZ	PPIA PPIB PPIF	2.30e-06	12	51	3	CID005287816
Drug	cyclosporin analogs	PPIA PPIB PPIF	3.79e-06	14	51	3	CID006475371
Drug	L-Proline	PPIA PPIB PPIF	1.18e-05	20	51	3	DB00172
Drug	3,6-anhydro-D-galactose 2-sulfate	SEPTIN5 ITGA1 HIRA TBX5	1.37e-05	65	51	4	CID000446806
Drug	GW5638	PPIA PPIB PPIF	1.37e-05	21	51	3	CID005288494
Drug	AC1L85AO	ABCB11 PPIA PPIB PPIF	1.45e-05	66	51	4	CID000372705
Drug	ketomycin	IARS2 LARS1	1.47e-05	3	51	2	CID000019489
Drug	AC1NUTKL	PPIA PPIB PPIF	2.07e-05	24	51	3	CID005426157
Drug	AC1O5U0X	PPIA PPIB PPIF	2.07e-05	24	51	3	CID006440684
Drug	AC1NUUB8	PPIA PPIB PPIF	4.55e-05	31	51	3	CID005493639
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CNGB3 CUL9 RP2 ELP3 HIRA	7.65e-05	196	51	5	1494_DN
Drug	AC1O5KXC	PPIA PPIB PPIF	7.80e-05	37	51	3	CID006436011
Drug	AC1L19WH	IARS2 LARS1 GFM2	7.80e-05	37	51	3	CID000000733
Drug	Merbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A	SPTLC3 CUL9 ELP3 USP15 NNT	8.22e-05	199	51	5	7398_DN
Drug	NBD-Cl	ATP6V1B1 RP2 NNT	8.45e-05	38	51	3	CID000025043
Drug	Pl-cs	PPIA PPIB YME1L1 PPIF	9.72e-05	107	51	4	CID006450086
Disease	peak expiratory flow	BBS7 TBCK PSMB3 ITGA1 FREM3 NNT PHGDH	1.99e-05	498	50	7	EFO_0009718
Disease	serum gamma-glutamyl transferase measurement	TYW1B TLN1 ABCB11 ZER1 IFT80 ITGA1 PPIA PPIF	1.39e-04	914	50	8	EFO_0004532
Disease	Disorder of eye	PDE6B BBS7 CNGB3 RP2	4.60e-04	212	50	4	C0015397
Disease	Retinal Degeneration	PDE6B IFT80	5.79e-04	21	50	2	C0035304
Disease	Cholestasis	VIL1 PAN2 ABCB11	8.70e-04	110	50	3	C0008370
Disease	Polydactyly	BBS7 IFT80 TBX5	1.04e-03	117	50	3	C0152427
Disease	mitochondrial metabolism disease (implicated_via_orthology)	IARS2 YME1L1	1.62e-03	35	50	2	DOID:700 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ATQKVVIGDHDGVVM	BBS7	31	Q8IWZ6
MEQVHRGIKGVVTDE	AEBP1	901	Q8IUX7
MQVVAVEGKGEVKHG	ACBD5	366	Q5T8D3
IAVMAQGVVIEKGTH	ABCB11	1286	O95342
HVVFGFVKDGMDTVK	RANBP2	3186	P49792
SGMGVIVHIIEKDKI	PSMB3	181	P49720
EVAFKMAVKKHGGEI	PAN2	761	Q504Q3
IGVVGHVAQTKKMVN	PDE6B	136	P35913
VMVVVEQIKSQKIHG	TUBGCP4	136	Q9UGJ1
GVKKVMVIVTDGESH	ITGA1	271	P56199
FGKEEQIIKLGTMVH	IFT80	496	Q9P2H3
ISIVVDGGKKVVEFM	COL19A1	131	Q14993
KQLGHSVDKVEFIVM	ELP3	156	Q9H9T3
EIQDNTGKMEVVVHG	IFI16	706	Q16666
GKVGVEEGKAEHILM	CUL9	51	Q8IWT3
NMDFVGHRKAVTVVK	HIRA	261	P54198
EVQKFVNKGEKGIMV	NHP2	66	Q9NX24
MVTGEGHILVDTKKI	KIF28P	796	B7ZC32
ENTEVMIKGGGLKHV	UPF2	1091	Q9HAU5
HVIRGTVVMKDGKVI	NNT	421	Q13423
EITMGVIHGKRKDVG	FREM3	966	P0C091
AIGKDVQAMKAVVGE	ATP6V1B1	421	P15313
IGEAKTFKGVVDVVM	GFM2	226	Q969S9
DVGFMKALHEKVNIV	SEPTIN5	171	Q99719
HVVFGKVKEGMNIVE	PPIA	126	P62937
KFHEVGTEMIITKAG	TBX5	66	Q99593
IMLVDGFKGQKVQDV	LARS1	476	Q9P2J5
HVVFGKVLEGMEVVR	PPIB	166	P23284
GIQVTMVIEVGKKHG	RNF128	186	Q8TEB7
GDVVHVPNMKVEVKA	MYCBP2	2296	O75592
GKHVVFGHVKEGMDV	PPIF	166	P30405
FGHVKEGMDVVKKIE	PPIF	171	P30405
VIVHGFTLGEKGEKM	IARS2	651	Q9NSE4
RHMLEKKIGVVVVGF	SPTLC3	476	Q9NUV7
EIGKEMYIIKHGEVQ	CNGB3	556	Q9NQW8
HVKGKRNVVAGEVEM	VIL1	141	P09327
EVGLGEKEHMRVVVK	ZBTB5	316	O15062
DNDHKEAVGKMGFVV	ZER1	511	Q7Z7L7
ETVVVKEKMVGGIAQ	TLN1	2486	Q9Y490
HVEMQTKGKVVGLIQ	SERPINA7	176	P05543
EMVGKGFFLVQTKEV	RP2	256	O75695
KVVEQGMFVKHCKVE	USP15	116	Q9Y4E8
EEKVGIYKLTGAVMH	MYH13	346	Q9UKX3
HAEVVKKVNEMIVTG	MRPL21	76	Q7Z2W9
MLQNFKGKVIVIVGH	TBCK	836	Q8TEA7
VQMKNVTFEHVKGVE	YME1L1	331	Q96TA2
GEEIAVQFVDMVKGK	PHGDH	296	O43175
VAKMIQEVKGEVTIH	PICK1	86	Q9NRD5
KIHVVEAGKEFDLVM	ZMYND15	511	Q9H091
GHKGEVAEEFGIIMK	USP8	821	P40818
EKIGVHVGFEEILNM	USP44	586	Q9H0E7
GVKAERFEEGMTVKH	TYW1B	401	Q6NUM6