Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionzinc ion binding

ADAMTS2 FNTB PEG10 SUV39H1 ERVK-8 GATA3 GATA4 LANCL1 ERVK-19 NR1H3 NR1H2 NR5A1 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 AR SHANK3 ZCCHC13 POLR3A ADH4

4.50e-118919022GO:0008270
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.75e-1037907GO:0004190
GeneOntologyMolecularFunctiontransition metal ion binding

FN1 ADAMTS2 FNTB PEG10 SUV39H1 ERVK-8 GATA3 GATA4 LANCL1 ERVK-19 NR1H3 NR1H2 NR5A1 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 MUC2 AR SHANK3 ZCCHC13 POLR3A ADH4

3.11e-1011899024GO:0046914
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

3.36e-1038907GO:0070001
GeneOntologyMolecularFunctionstructural molecule activity

SLIT2 FRAS1 FBN1 MARVELD1 FN1 CSRP2 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 TUBGCP4 ERVK-24 MUC2 SHANK3

2.09e-068919016GO:0005198
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-7 ERVK-10

1.42e-0511903GO:0004523
GeneOntologyMolecularFunction3-mercaptopyruvate sulfurtransferase activity

MPST TST

2.01e-052902GO:0016784
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-7 ERVK-10 ELAC2

2.27e-0537904GO:0016891
GeneOntologyMolecularFunctionendopeptidase activity

NLN THOP1 ADAMTS2 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.38e-054309010GO:0004175
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-7 ERVK-10

3.11e-0514903GO:0003964
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-7 ERVK-10 ELAC2

5.45e-0546904GO:0016893
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-7 ERVK-10

1.11e-0421903GO:0035613
GeneOntologyMolecularFunctionintegrin binding

SELP SFRP2 FBN1 FN1 CD9 CD81

1.41e-04175906GO:0005178
GeneOntologyMolecularFunctionnuclear receptor activity

NR1H3 NR1H2 NR5A1 AR

1.55e-0460904GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

NR1H3 NR1H2 NR5A1 AR

1.65e-0461904GO:0098531
GeneOntologyMolecularFunctionthiosulfate sulfurtransferase activity

MPST TST

1.99e-045902GO:0004792
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-7 ERVK-10 ELAC2

4.48e-0479904GO:0004521
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-7 ERVK-10

6.66e-0438903GO:0034061
GeneOntologyMolecularFunctionpeptidase activity

NLN THOP1 ADAMTS2 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

7.18e-046549010GO:0008233
GeneOntologyMolecularFunctionsulfurtransferase activity

MPST TST

1.29e-0312902GO:0016783
GeneOntologyMolecularFunctionproteoglycan binding

SLIT2 FN1 LRP1

1.58e-0351903GO:0043394
GeneOntologyMolecularFunctionextracellular matrix structural constituent

SLIT2 FRAS1 FBN1 FN1 MUC2

1.61e-03188905GO:0005201
GeneOntologyMolecularFunctiontranscription coactivator binding

GATA3 GATA4 AR

1.86e-0354903GO:0001223
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRMT2 NR1H3 NR1H2

1.96e-0355903GO:0042974
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP6

2.31e-0316902GO:0005041
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

FIZ1 GATA3 GATA4 PRMT2 NR1H3 NR1H2 AR

2.78e-03417907GO:0061629
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-8 ERVK-7 ERVK-10 ELAC2

3.35e-03136904GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-7 ERVK-10 ELAC2

3.35e-03136904GO:0004519
GeneOntologyMolecularFunctionsulfur compound binding

SELP SLIT2 FBN1 FN1 LRP1 LANCL1

3.41e-03323906GO:1901681
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP6

3.62e-0320902GO:0034185
GeneOntologyMolecularFunctiontranscription coregulator binding

GATA3 GATA4 NR5A1 AR

3.71e-03140904GO:0001221
GeneOntologyMolecularFunctionpeptidase activator activity

SFRP2 PSME4 FN1

3.90e-0370903GO:0016504
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP6

3.99e-0321902GO:0030228
GeneOntologyMolecularFunctionhistone methyltransferase activity

SUV39H1 PRMT2 PRDM6

4.06e-0371903GO:0042054
GeneOntologyMolecularFunctiontransferase activity, transferring sulphur-containing groups

MPST WSCD2 TST

4.56e-0374903GO:0016782
GeneOntologyMolecularFunctionnuclear retinoid X receptor binding

NR1H3 NR1H2

4.78e-0323902GO:0046965
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-7 ERVK-10 POLR3A

4.97e-03152904GO:0016779
GeneOntologyBiologicalProcesscell-cell fusion

CD9 ERVK-8 ERVK-19 CD81 ERVK-21 ERVK-9

1.81e-0685896GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

CD9 ERVK-8 ERVK-19 CD81 ERVK-21 ERVK-9

1.81e-0685896GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

CD9 ERVK-8 ERVK-19 CD81 ERVK-21 ERVK-9

2.37e-0689896GO:0006949
GeneOntologyBiologicalProcesscyanate catabolic process

MPST TST

1.84e-052892GO:0009440
GeneOntologyBiologicalProcesscyanate metabolic process

MPST TST

1.84e-052892GO:0009439
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-7 ERVK-10

2.15e-0513893GO:0015074
GeneOntologyBiologicalProcessaortic valve morphogenesis

SLIT2 GATA3 GATA4 NOTCH1

2.37e-0539894GO:0003180
GeneOntologyBiologicalProcesscardiac septum development

SLIT2 GATA3 GATA4 LRP1 LRP6 NOTCH1

2.51e-05134896GO:0003279
GeneOntologyBiologicalProcessdevelopmental growth

SLIT2 SFRP2 FN1 CD9 DHCR7 SUV39H1 GATA3 GATA4 LRP1 LRP6 PRMT2 CD81 AR NOTCH1

3.39e-059118914GO:0048589
GeneOntologyBiologicalProcesscardiac chamber development

SLIT2 SFRP2 GATA3 GATA4 LRP1 LRP6 NOTCH1

3.71e-05212897GO:0003205
GeneOntologyBiologicalProcessaortic valve development

SLIT2 GATA3 GATA4 NOTCH1

4.60e-0546894GO:0003176
GeneOntologyBiologicalProcessventricular septum development

SLIT2 GATA3 GATA4 LRP6 NOTCH1

4.64e-0591895GO:0003281
GeneOntologyBiologicalProcessregulation of secretion of lysosomal enzymes

NR1H3 NR1H2

5.51e-053892GO:0090182
GeneOntologyBiologicalProcesssemi-lunar valve development

SLIT2 GATA3 GATA4 NOTCH1

6.41e-0550894GO:1905314
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

SLIT2 SFRP2 GATA3 GATA4 LRP6 NOTCH1

7.02e-05161896GO:0003206
GeneOntologyBiologicalProcesscardiac ventricle development

SLIT2 SFRP2 GATA3 GATA4 LRP6 NOTCH1

7.02e-05161896GO:0003231
GeneOntologyBiologicalProcesscardiac right ventricle morphogenesis

GATA3 GATA4 NOTCH1

9.76e-0521893GO:0003215
GeneOntologyBiologicalProcessnegative regulation of Wnt signaling pathway, planar cell polarity pathway

SFRP2 LRP6

1.10e-044892GO:0141113
GeneOntologyBiologicalProcessWnt signaling pathway involved in somitogenesis

SFRP2 LRP6

1.10e-044892GO:0090244
GeneOntologyBiologicalProcesspositive regulation of miRNA transcription

GATA3 GATA4 NR1H2 AR

1.40e-0461894GO:1902895
GeneOntologyBiologicalProcessheart valve morphogenesis

SLIT2 GATA3 GATA4 NOTCH1

1.59e-0463894GO:0003179
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-19 CD81 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 NOTCH1

1.77e-04464899GO:0016032
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

SLIT2 SFRP2 FN1 CD9 CSRP2 ERVK-8 GATA3 GATA4 LRP6 ERVK-19 CD81 ERVK-21 ERVK-9 AR SHANK3 NOTCH1 CRB1

1.78e-0414838917GO:0048646
GeneOntologyBiologicalProcessmitral valve formation

GATA4 NOTCH1

1.83e-045892GO:0003192
GeneOntologyBiologicalProcesspositive regulation of cholesterol efflux

LRP1 NR1H3 NR1H2

2.11e-0427893GO:0010875
GeneOntologyBiologicalProcessintegrin activation

SELP FN1 PIEZO1

2.62e-0429893GO:0033622
GeneOntologyBiologicalProcessnegative regulation of pinocytosis

NR1H3 NR1H2

2.73e-046892GO:0048550
GeneOntologyBiologicalProcesspositive regulation of miRNA metabolic process

GATA3 GATA4 NR1H2 AR

2.81e-0473894GO:2000630
GeneOntologyBiologicalProcesscellular response to hormone stimulus

FBN1 SCGB2A2 GATA4 SCNN1D PRMT2 NR1H3 NR1H2 NR5A1 SLC39A14 AR NOTCH1

2.90e-047278911GO:0032870
GeneOntologyBiologicalProcessheart valve development

SLIT2 GATA3 GATA4 NOTCH1

3.62e-0478894GO:0003170
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 CD81

3.81e-047892GO:1904352
GeneOntologyBiologicalProcessmyoblast fusion involved in skeletal muscle regeneration

CD9 CD81

3.81e-047892GO:0014905
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

SLIT2 SFRP2 FBN1 PEG10 GATA3 GATA4 LRP1 NOTCH1

4.08e-04412898GO:0090287
GeneOntologyBiologicalProcessregulation of miRNA transcription

GATA3 GATA4 NR1H2 AR

4.59e-0483894GO:1902893
GeneOntologyBiologicalProcessepithelial tube morphogenesis

SLIT2 SFRP2 GATA3 GATA4 LRP6 AR SHANK3 NOTCH1

4.71e-04421898GO:0060562
GeneOntologyBiologicalProcessmammary gland epithelium development

SLIT2 GATA3 LRP6 AR

4.80e-0484894GO:0061180
GeneOntologyBiologicalProcessmiRNA transcription

GATA3 GATA4 NR1H2 AR

4.80e-0484894GO:0061614
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

SLIT2 SFRP2 FBN1 GATA3 NOTCH1

4.83e-04150895GO:0090288
GeneOntologyBiologicalProcessnegative regulation of response to type II interferon

NR1H3 NR1H2

5.07e-048892GO:0060331
GeneOntologyBiologicalProcessnegative regulation of type II interferon-mediated signaling pathway

NR1H3 NR1H2

5.07e-048892GO:0060336
GeneOntologyBiologicalProcesspositive regulation of lipoprotein lipase activity

NR1H3 NR1H2

5.07e-048892GO:0051006
GeneOntologyBiologicalProcessregulation of type 2 immune response

GATA3 CD81 IL27RA

5.43e-0437893GO:0002828
GeneOntologyBiologicalProcesscardiac ventricle morphogenesis

SFRP2 GATA3 GATA4 NOTCH1

5.73e-0488894GO:0003208
GeneOntologyBiologicalProcesscardiac septum morphogenesis

SLIT2 GATA4 LRP6 NOTCH1

5.98e-0489894GO:0060411
GeneOntologyBiologicalProcessatrioventricular node development

GATA4 NOTCH1

6.50e-049892GO:0003162
GeneOntologyBiologicalProcessatrioventricular valve formation

GATA4 NOTCH1

6.50e-049892GO:0003190
GeneOntologyBiologicalProcessnegative regulation of non-canonical Wnt signaling pathway

SFRP2 LRP6

6.50e-049892GO:2000051
GeneOntologyBiologicalProcesspericardium morphogenesis

LRP6 NOTCH1

6.50e-049892GO:0003344
GeneOntologyBiologicalProcessregulation of pancreatic juice secretion

NR1H3 NR1H2

6.50e-049892GO:0090186
GeneOntologyBiologicalProcesscell surface receptor signaling pathway involved in heart development

LRP6 NOTCH1

6.50e-049892GO:0061311
GeneOntologyBiologicalProcesspositive regulation of triglyceride lipase activity

NR1H3 NR1H2

6.50e-049892GO:0061365
GeneOntologyBiologicalProcesshormone-mediated signaling pathway

SCGB2A2 PRMT2 NR1H3 NR1H2 NR5A1 AR

6.60e-04244896GO:0009755
GeneOntologyBiologicalProcesspositive regulation of sterol transport

LRP1 NR1H3 NR1H2

6.84e-0440893GO:0032373
GeneOntologyBiologicalProcesspositive regulation of cholesterol transport

LRP1 NR1H3 NR1H2

6.84e-0440893GO:0032376
GeneOntologyBiologicalProcessregulation of hormone levels

FBN1 PNPLA4 DHCR7 GATA3 LRP1 NR5A1 UGT2B28 SLC39A14 PFKM ADH4

7.24e-046848910GO:0010817
GeneOntologyBiologicalProcessmyotube differentiation

NLN CD9 PIEZO1 CD81 NOTCH1

7.25e-04164895GO:0014902
GeneOntologyBiologicalProcessoutflow tract morphogenesis

SFRP2 GATA4 LRP6 NOTCH1

7.35e-0494894GO:0003151
GeneOntologyBiologicalProcessregulation of lipase activity

LRP1 NR1H3 NR1H2

7.35e-0441893GO:0060191
GeneOntologyBiologicalProcessgrowth

SLIT2 SFRP2 FN1 CD9 DHCR7 SUV39H1 GATA3 GATA4 LRP1 LRP6 PRMT2 CD81 AR NOTCH1

7.95e-0412358914GO:0040007
GeneOntologyBiologicalProcesspositive regulation of T-helper 2 cell cytokine production

GATA3 CD81

8.10e-0410892GO:2000553
GeneOntologyBiologicalProcesssecretion of lysosomal enzymes

NR1H3 NR1H2

8.10e-0410892GO:0033299
GeneOntologyBiologicalProcesssex differentiation

SFRP2 GATA3 GATA4 LRP6 NR5A1 AR NOTCH1

8.26e-04352897GO:0007548
GeneOntologyBiologicalProcessmale gonad development

SFRP2 GATA3 GATA4 NR5A1 AR

8.74e-04171895GO:0008584
GeneOntologyBiologicalProcesstissue regeneration

CD9 GATA4 CD81 NOTCH1

8.92e-0499894GO:0042246
GeneOntologyBiologicalProcessdevelopment of primary male sexual characteristics

SFRP2 GATA3 GATA4 NR5A1 AR

8.98e-04172895GO:0046546
GeneOntologyBiologicalProcessmammary gland duct morphogenesis

SLIT2 LRP6 AR

9.67e-0445893GO:0060603
GeneOntologyBiologicalProcesssulfur amino acid catabolic process

MPST TST

9.87e-0411892GO:0000098
GeneOntologyBiologicalProcesscellular response to X-ray

SFRP2 GATA3

9.87e-0411892GO:0071481
GeneOntologyBiologicalProcessregulation of epithelial cell proliferation involved in prostate gland development

AR NOTCH1

9.87e-0411892GO:0060768
GeneOntologyBiologicalProcessmyotube differentiation involved in skeletal muscle regeneration

CD9 CD81

9.87e-0411892GO:0014908
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

GATA3 GATA4 NR1H2 AR

1.03e-03103894GO:2000628
GeneOntologyBiologicalProcessnegative regulation of cytokine-mediated signaling pathway

SLIT2 NR1H3 NR1H2 YTHDF3

1.15e-03106894GO:0001960
GeneOntologyBiologicalProcessnegative regulation of cold-induced thermogenesis

NR1H3 NR1H2 NOTCH1

1.17e-0348893GO:0120163
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-8 ERVK-7 ERVK-10

1.17e-0348893GO:0000731
GeneOntologyBiologicalProcessnegative regulation of cholesterol storage

NR1H3 NR1H2

1.18e-0312892GO:0010887
GeneOntologyBiologicalProcessepithelial cell proliferation involved in prostate gland development

AR NOTCH1

1.18e-0312892GO:0060767
GeneOntologyBiologicalProcessforegut morphogenesis

GATA4 NOTCH1

1.18e-0312892GO:0007440
GeneOntologyBiologicalProcesstube formation

SFRP2 GATA3 LRP6 SHANK3 NOTCH1

1.30e-03187895GO:0035148
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

SFRP2 GATA3 LRP6 AR

1.32e-03110894GO:2000027
GeneOntologyBiologicalProcessreproductive structure development

SFRP2 GATA3 GATA4 LRP6 NR5A1 AR NOTCH1

1.35e-03383897GO:0048608
GeneOntologyBiologicalProcessnegative regulation of response to cytokine stimulus

SLIT2 NR1H3 NR1H2 YTHDF3

1.36e-03111894GO:0060761
GeneOntologyBiologicalProcessLeydig cell differentiation

NR5A1 AR

1.39e-0313892GO:0033327
GeneOntologyBiologicalProcessandrogen receptor signaling pathway

SCGB2A2 PRMT2 AR

1.39e-0351893GO:0030521
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

SFRP2 GATA3 LRP6 AR SHANK3

1.40e-03190895GO:0016331
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

SLIT2 FRAS1 SFRP2 GATA3 GATA4 LRP6 AR SHANK3 NOTCH1

1.40e-03619899GO:0002009
GeneOntologyBiologicalProcessreproductive system development

SFRP2 GATA3 GATA4 LRP6 NR5A1 AR NOTCH1

1.45e-03388897GO:0061458
GeneOntologyBiologicalProcesshormone metabolic process

PNPLA4 DHCR7 GATA3 NR5A1 UGT2B28 ADH4

1.50e-03286896GO:0042445
GeneOntologyBiologicalProcessstriated muscle cell differentiation

NLN CD9 PIEZO1 CSRP2 GATA4 CD81 NOTCH1

1.51e-03391897GO:0051146
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LRP1 CD81

1.62e-0314892GO:1904350
GeneOntologyBiologicalProcessphosphatidylcholine acyl-chain remodeling

NR1H3 NR1H2

1.62e-0314892GO:0036151
GeneOntologyBiologicalProcessregulation of pinocytosis

NR1H3 NR1H2

1.62e-0314892GO:0048548
GeneOntologyBiologicalProcessregulation of T-helper 2 cell cytokine production

GATA3 CD81

1.62e-0314892GO:2000551
GeneOntologyBiologicalProcesspancreatic juice secretion

NR1H3 NR1H2

1.62e-0314892GO:0030157
GeneOntologyBiologicalProcessgonad development

SFRP2 GATA3 GATA4 NR5A1 AR NOTCH1

1.66e-03292896GO:0008406
GeneOntologyBiologicalProcessbranching morphogenesis of an epithelial tube

SLIT2 SFRP2 LRP6 AR NOTCH1

1.68e-03198895GO:0048754
GeneOntologyBiologicalProcessresponse to hormone

FBN1 SCGB2A2 GATA4 SCNN1D LRP6 PRMT2 NR1H3 NR1H2 NR5A1 SLC39A14 AR NOTCH1

1.70e-0310428912GO:0009725
GeneOntologyBiologicalProcessmale sex differentiation

SFRP2 GATA3 GATA4 NR5A1 AR

1.71e-03199895GO:0046661
GeneOntologyBiologicalProcessregulation of myotube differentiation

NLN PIEZO1 NOTCH1

1.73e-0355893GO:0010830
GeneOntologyBiologicalProcesstype 2 immune response

GATA3 CD81 IL27RA

1.73e-0355893GO:0042092
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

SFRP2 CELSR3 LRP6

1.73e-0355893GO:0060071
HumanPhenoAbsent hair

FRAS1 LRP1 NR5A1 AR POLR3A

1.38e-0561275HP:0002298
HumanPhenoClitoral hypertrophy

FRAS1 DHCR7 GATA4 NR5A1 AR

2.71e-0570275HP:0008665
HumanPhenoAbnormal size of the clitoris

FRAS1 DHCR7 GATA4 NR5A1 AR

2.71e-0570275HP:0040252
HumanPhenoIncreased size of the clitoris

FRAS1 DHCR7 GATA4 NR5A1 AR

2.71e-0570275HP:0040253
HumanPhenoAbsent facial hair

FRAS1 LRP1 AR POLR3A

4.09e-0538274HP:0002550
HumanPhenoAbnormal vagina morphology

FRAS1 DHCR7 GATA3 GATA4 NR5A1 AR

4.30e-05128276HP:0000142
HumanPhenoIncreased total bilirubin

PRF1 PIEZO1 PFKM

4.65e-0514273HP:0003573
HumanPhenoFused labia majora

NR5A1 AR

8.09e-053272HP:0025486
HumanPhenoFemale external genitalia in individual with 46,XY karyotype

GATA4 NR5A1 AR

8.60e-0517273HP:0008730
HumanPhenoUrogenital sinus anomaly

GATA4 NR5A1 AR

1.03e-0418273HP:0100779
HumanPhenoAbnormal clitoris morphology

FRAS1 DHCR7 GATA4 NR5A1 AR

1.51e-04100275HP:0000056
DomainEGF-like_dom

SELP SLIT2 FRAS1 FBN1 FCGBP CELSR3 PRF1 LRP1 LRP6 NOTCH1 CRB1

1.31e-082498311IPR000742
DomainEGF

SELP SLIT2 FRAS1 FBN1 FCGBP CELSR3 LRP1 LRP6 NOTCH1 CRB1

8.95e-082358310SM00181
DomainEGF_1

SELP SLIT2 FBN1 CELSR3 FN1 PRF1 LRP1 LRP6 NOTCH1 CRB1

1.91e-072558310PS00022
Domain-

GATA3 GATA4 NR1H3 NR1H2 NR5A1 AR

1.94e-07578363.30.50.10
DomainZnf_NHR/GATA

GATA3 GATA4 NR1H3 NR1H2 NR5A1 AR

2.16e-0758836IPR013088
DomainEGF-like_CS

SELP SLIT2 FBN1 CELSR3 FN1 PRF1 LRP1 LRP6 NOTCH1 CRB1

2.37e-072618310IPR013032
DomainEGF_3

SELP SLIT2 FBN1 CELSR3 PRF1 LRP1 LRP6 NOTCH1 CRB1

9.93e-07235839PS50026
DomainVWC_out

FRAS1 FCGBP MUC5B MUC2

1.34e-0619834SM00215
DomainEGF

SELP SLIT2 CELSR3 LRP1 LRP6 NOTCH1 CRB1

1.46e-06126837PF00008
DomainEGF_2

SELP SLIT2 FBN1 CELSR3 PRF1 LRP1 LRP6 NOTCH1 CRB1

2.68e-06265839PS01186
DomainASX_HYDROXYL

SLIT2 FBN1 CELSR3 LRP1 NOTCH1 CRB1

5.48e-06100836PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

SLIT2 FBN1 CELSR3 LRP1 NOTCH1 CRB1

7.68e-06106836IPR000152
DomainEGF_CA

SLIT2 FBN1 CELSR3 LRP1 NOTCH1 CRB1

1.72e-05122836SM00179
DomainTIL

FCGBP MUC5B MUC2

1.81e-0512833PF01826
DomainC8

FCGBP MUC5B MUC2

1.81e-0512833PF08742
DomainEGF-like_Ca-bd_dom

SLIT2 FBN1 CELSR3 LRP1 NOTCH1 CRB1

1.89e-05124836IPR001881
DomainRHODANESE_2

MPST TST

1.95e-052832PS00683
DomainRHODANESE_1

MPST TST

1.95e-052832PS00380
DomainLiver_X_rcpt

NR1H3 NR1H2

1.95e-052832IPR023257
DomainUnchr_dom_Cys-rich

FCGBP MUC5B MUC2

2.34e-0513833IPR014853
DomainC8

FCGBP MUC5B MUC2

2.34e-0513833SM00832
DomainVWC

FRAS1 FCGBP MUC5B MUC2

2.39e-0538834SM00214
DomainTIL_dom

FCGBP MUC5B MUC2

2.97e-0514833IPR002919
DomainVWF_dom

FRAS1 FCGBP MUC5B MUC2

3.57e-0542834IPR001007
DomainVWD

FCGBP MUC5B MUC2

4.55e-0516833SM00216
DomainVWF_type-D

FCGBP MUC5B MUC2

4.55e-0516833IPR001846
DomainVWFD

FCGBP MUC5B MUC2

4.55e-0516833PS51233
DomainVWD

FCGBP MUC5B MUC2

4.55e-0516833PF00094
Domainzf-C4

NR1H3 NR1H2 NR5A1 AR

5.13e-0546834PF00105
DomainZnf_hrmn_rcpt

NR1H3 NR1H2 NR5A1 AR

5.13e-0546834IPR001628
DomainNUCLEAR_REC_DBD_2

NR1H3 NR1H2 NR5A1 AR

5.13e-0546834PS51030
DomainNUCLEAR_REC_DBD_1

NR1H3 NR1H2 NR5A1 AR

5.13e-0546834PS00031
DomainZnF_C4

NR1H3 NR1H2 NR5A1 AR

5.13e-0546834SM00399
Domain-

NR1H3 NR1H2 NR5A1 AR

5.59e-05478341.10.565.10
Domain-

NLN THOP1

5.84e-0538321.20.1050.40
DomainPept_M3A_M3B

NLN THOP1

5.84e-053832IPR001567
DomainThiosulphate_STrfase_CS

MPST TST

5.84e-053832IPR001307
DomainPeptidase_M3

NLN THOP1

5.84e-053832PF01432
Domain-

NLN THOP1

5.84e-0538321.10.1370.10
DomainNeurolysin/TOP_N

NLN THOP1

5.84e-053832IPR024080
DomainNeurolysin/TOP_dom2

NLN THOP1

5.84e-053832IPR024077
DomainHOLI

NR1H3 NR1H2 NR5A1 AR

6.08e-0548834SM00430
DomainNucl_hrmn_rcpt_lig-bd

NR1H3 NR1H2 NR5A1 AR

6.08e-0548834IPR000536
DomainHormone_recep

NR1H3 NR1H2 NR5A1 AR

6.08e-0548834PF00104
DomainCTCK_1

SLIT2 MUC5B MUC2

6.58e-0518833PS01185
DomainEGF_Ca-bd_CS

SLIT2 FBN1 LRP1 NOTCH1 CRB1

7.18e-0597835IPR018097
DomainEGF_CA

SLIT2 FBN1 LRP1 NOTCH1 CRB1

7.91e-0599835PS01187
DomainCT

SLIT2 MUC5B MUC2

1.23e-0422833SM00041
DomainCys_knot_C

SLIT2 MUC5B MUC2

1.81e-0425833IPR006207
DomainCTCK_2

SLIT2 MUC5B MUC2

1.81e-0425833PS01225
Domain-

CD9 CD81

1.93e-0458321.10.1450.10
DomainCD81_LEL

CD9 CD81

1.93e-045832IPR028977
DomainhEGF

SLIT2 NOTCH1 CRB1

2.56e-0428833PF12661
DomainWxxW_domain

MUC5B MUC2

2.89e-046832IPR025155
DomainMucin2_WxxW

MUC5B MUC2

2.89e-046832PF13330
DomainVWFC_1

FRAS1 MUC5B MUC2

5.44e-0436833PS01208
DomainVWFC_2

FRAS1 MUC5B MUC2

6.38e-0438833PS50184
DomainLAM_G_DOMAIN

SLIT2 CELSR3 CRB1

6.38e-0438833PS50025
DomainGrowth_fac_rcpt_

FRAS1 FBN1 LRP1 NOTCH1 CRB1

6.55e-04156835IPR009030
DomainLaminin_G_2

SLIT2 CELSR3 CRB1

7.43e-0440833PF02210
DomainLamG

SLIT2 CELSR3 CRB1

9.83e-0444833SM00282
DomainFol_N

SLIT2 FCGBP

1.05e-0311832IPR003645
DomainFOLN

SLIT2 FCGBP

1.05e-0311832SM00274
DomainNuclear_hrmn_rcpt

NR1H3 NR1H2 NR5A1

1.12e-0346833IPR001723
DomainZnF_GATA

GATA3 GATA4

1.25e-0312832SM00401
DomainVitD_rcpt

NR1H2 NR5A1

1.72e-0314832IPR000324
DomainLdl_recept_b

LRP1 LRP6

1.72e-0314832PF00058
DomainLDLRB

LRP1 LRP6

1.72e-0314832PS51120
DomainZnf_GATA

GATA3 GATA4

1.97e-0315832IPR000679
DomainGATA

GATA3 GATA4

1.97e-0315832PF00320
DomainLY

LRP1 LRP6

1.97e-0315832SM00135
DomainLDLR_classB_rpt

LRP1 LRP6

1.97e-0315832IPR000033
DomainLaminin_G

SLIT2 CELSR3 CRB1

2.19e-0358833IPR001791
DomainGATA_ZN_FINGER_1

GATA3 GATA4

2.25e-0316832PS00344
DomainGATA_ZN_FINGER_2

GATA3 GATA4

2.25e-0316832PS50114
DomainTetraspanin_CS

CD9 CD81

3.88e-0321832IPR018503
DomainRHOD

MPST TST

4.25e-0322832SM00450
PathwayREACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS

NR1H3 NR1H2 NR5A1 AR

4.91e-0628584MM15042
PathwayREACTOME_SUMOYLATION_OF_INTRACELLULAR_RECEPTORS

NR1H3 NR1H2 NR5A1 AR

6.53e-0630584M27323
PathwayWP_NUCLEAR_RECEPTORS

NR1H3 NR1H2 NR5A1 AR

1.72e-0538584M39657
PathwayWP_NUCLEAR_RECEPTORS

NR1H3 NR1H2 NR5A1 AR

1.72e-0538584MM15865
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR1H3 NR1H2 NR5A1 AR

4.39e-0548584MM14987
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR1H3 NR1H2 NR5A1 AR

6.50e-0553584M8276
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE

NR1H3 NR1H2

1.65e-045582M29791
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE

NR1H3 NR1H2

1.65e-045582M29792
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

NR1H3 NR1H2

2.47e-046582MM15663
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

5.65e-099491721542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-19 ERVK-21 ERVK-9

2.14e-081291414557543
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-7 ERVK-10 ERVK-24

6.92e-08491310469592
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.30e-071891418664271
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-19 ERVK-7 ERVK-21

1.73e-07591312629516
Pubmed

Nuclear receptors in Leydig cell gene expression and function.

NR1H3 NR1H2 NR5A1 AR

3.09e-072291420375256
Pubmed

CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82.

CD9 LRP1 CD81

3.45e-0769139804823
Pubmed

GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.

GATA3 GATA4 AR

6.02e-07791318212046
Pubmed

Phagocytosis imprints heterogeneity in tissue-resident macrophages.

SELP NR1H3 NR1H2

9.61e-07891328432199
Pubmed

Rhythmic modulation of the hematopoietic niche through neutrophil clearance.

SELP NR1H3 NR1H2

9.61e-07891323706740
Pubmed

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

DHCR7 LRP1 NR1H3 NR1H2

1.31e-063191419796621
Pubmed

In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells.

FN1 GATA3 GATA4 NR5A1

2.71e-063791439178848
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FRAS1 FBN1 CELSR3 BTD PIEZO1 DHCR7 LRP1 LRP6 LANCL1 SLC39A14 ELAC2 NOTCH1 TMED4 DMXL1

2.85e-061201911435696571
Pubmed

Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.

LRP1 NR1H3 NR1H2

3.75e-061291322027013
Pubmed

Sfrp1 and Sfrp2 are required for normal male sexual development in mice.

SFRP2 NR5A1 AR

4.86e-061391319100252
Pubmed

LXR deficiency confers increased protection against visceral Leishmania infection in mice.

NR1H3 NR1H2

6.77e-06291221103366
Pubmed

Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.

NR1H3 NR1H2

6.77e-06291219933273
Pubmed

Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.

NR1H3 NR1H2

6.77e-06291215539633
Pubmed

Liver X receptors regulate cerebrospinal fluid production.

NR1H3 NR1H2

6.77e-06291226324101
Pubmed

Suppression of beta-catenin signaling by liver X receptor ligands.

NR1H3 NR1H2

6.77e-06291218983830
Pubmed

Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes.

NR1H3 NR1H2

6.77e-06291223185273
Pubmed

Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.

CD9 CD81

6.77e-06291212483205
Pubmed

Fibrillin assembly requires fibronectin.

FBN1 FN1

6.77e-06291219037100
Pubmed

Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas.

NR1H3 NR1H2

6.77e-06291221356276
Pubmed

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.

NR1H3 NR1H2

6.77e-06291211149950
Pubmed

Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice.

NR1H3 NR1H2

6.77e-06291234799646
Pubmed

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.

NR1H3 NR1H2

6.77e-06291211851872
Pubmed

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

NR1H3 NR1H2

6.77e-06291216325781
Pubmed

Macrophages release plasma membrane-derived particles rich in accessible cholesterol.

NR1H3 NR1H2

6.77e-06291230127022
Pubmed

Liver X receptor β controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue.

NR1H3 NR1H2

6.77e-06291226504234
Pubmed

Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

NR1H3 NR1H2

6.77e-06291222984598
Pubmed

Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells.

NR1H3 NR1H2

6.77e-06291225980575
Pubmed

Liver X receptor in cholesterol metabolism.

NR1H3 NR1H2

6.77e-06291219837721
Pubmed

Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140.

NR1H3 NR1H2

6.77e-06291217391100
Pubmed

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.

NR1H3 NR1H2

6.77e-06291211792716
Pubmed

Accumulation of foam cells in liver X receptor-deficient mice.

NR1H3 NR1H2

6.77e-06291212196343
Pubmed

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.

NR1H3 NR1H2

6.77e-06291217693624
Pubmed

Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.

NR1H3 NR1H2

6.77e-06291226023184
Pubmed

Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury.

NR1H3 NR1H2

6.77e-06291219717840
Pubmed

Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.

NR1H3 NR1H2

6.77e-06291233284790
Pubmed

CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization.

CD9 CD81

6.77e-06291229671763
Pubmed

Lxrα regulates the androgen response in prostate epithelium.

NR1H3 NR1H2

6.77e-06291222547570
Pubmed

The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.

LRP6 YTHDF3

6.77e-06291238250152
Pubmed

Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.

NR1H3 NR1H2

6.77e-06291217766241
Pubmed

The medicinal chemistry of liver X receptor (LXR) modulators.

NR1H3 NR1H2

6.77e-06291224832115
Pubmed

Improved metabolic control by depletion of Liver X Receptors in mice.

NR1H3 NR1H2

6.77e-06291216876124
Pubmed

PLCε knockdown inhibits prostate cancer cell proliferation via suppression of Notch signalling and nuclear translocation of the androgen receptor.

AR NOTCH1

6.77e-06291225796442
Pubmed

Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma.

SUV39H1 NOTCH1

6.77e-06291238650654
Pubmed

Liver X receptors bridge hepatic lipid metabolism and inflammation.

NR1H3 NR1H2

6.77e-06291222257474
Pubmed

Liver X receptors control IgE expression in B cells.

NR1H3 NR1H2

6.77e-06291219380774
Pubmed

Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.

NR1H3 NR1H2

6.77e-06291217405904
Pubmed

Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice.

NR1H3 NR1H2

6.77e-06291227335465
Pubmed

Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling.

NR1H3 NR1H2

6.77e-06291219487338
Pubmed

Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.

NLN THOP1

6.77e-06291217620116
Pubmed

Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus.

NR1H3 NR1H2

6.77e-06291217166844
Pubmed

The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.

GATA4 MUC2

6.77e-06291215541382
Pubmed

Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.

NR1H3 NR1H2

6.77e-06291223823481
Pubmed

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.

NR1H3 NR1H2

6.77e-06291221042792
Pubmed

Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages.

NR1H3 NR1H2

6.77e-06291222367754
Pubmed

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.

NR1H3 NR1H2

6.77e-06291211546778
Pubmed

Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice.

NR1H3 NR1H2

6.77e-06291219122149
Pubmed

Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.

NR1H3 NR1H2

6.77e-06291215548517
Pubmed

Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.

CD9 CD81

6.77e-06291229572511
Pubmed

Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback.

NR1H3 NR1H2

6.77e-06291216973760
Pubmed

Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.

NR1H3 NR1H2

6.77e-06291218840761
Pubmed

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.

NR1H3 NR1H2

6.77e-06291217563384
Pubmed

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.

FCGBP MUC2

6.77e-06291234126068
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

6.77e-06291224484584
Pubmed

Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients.

MPST TST

6.77e-06291219695240
Pubmed

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.

NR1H3 NR1H2

6.77e-06291223292650
Pubmed

A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4.

GATA4 NR5A1

6.77e-06291212907682
Pubmed

Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.

NR1H3 NR1H2

6.77e-06291223686114
Pubmed

Dietary cholesterol-induced post-testicular infertility.

NR1H3 NR1H2

6.77e-06291222073227
Pubmed

Activation of Liver X Receptor Attenuates Oleic Acid-Induced Acute Respiratory Distress Syndrome.

NR1H3 NR1H2

6.77e-06291227520356
Pubmed

Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

NR1H3 NR1H2

6.77e-06291215525595
Pubmed

Laminar shear stress regulates liver X receptor in vascular endothelial cells.

NR1H3 NR1H2

6.77e-06291218096827
Pubmed

Cholestenoic acid analogues as inverse agonists of the liver X receptors.

NR1H3 NR1H2

6.77e-06291231931135
Pubmed

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.

PRMT2 AR

6.77e-06291217587566
Pubmed

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.

NR1H3 NR1H2

6.77e-06291212524534
Pubmed

Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.

NR1H3 NR1H2

6.77e-06291223675307
Pubmed

LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux.

NR1H3 NR1H2

6.77e-06291219996385
Pubmed

Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells.

NR1H3 NR1H2

6.77e-06291229739800
Pubmed

Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.

CD9 CD81

6.77e-06291218662991
Pubmed

Reduced fertility of female mice lacking CD81.

CD9 CD81

6.77e-06291216380109
Pubmed

GATA-3 expression is not associated with complete pathological response in triple negative breast cancer patients treated with neoadjuvant chemotherapy.

GATA3 AR

6.77e-06291227067807
Pubmed

Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.

NLN THOP1

6.77e-06291217251185
Pubmed

Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration.

NR1H3 NR1H2

6.77e-06291212368482
Pubmed

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.

NR1H3 NR1H2

6.77e-06291212040022
Pubmed

LXR-dependent gene expression is important for macrophage survival and the innate immune response.

NR1H3 NR1H2

6.77e-06291215479645
Pubmed

Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation.

NR1H3 NR1H2

6.77e-06291234297734
Pubmed

Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.

NR1H3 NR1H2

6.77e-06291234481107
Pubmed

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.

LRP1 LRP6

6.77e-06291226031789
Pubmed

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

NR1H3 NR1H2

6.77e-06291215761042
Pubmed

LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration.

NR1H3 NR1H2

6.77e-06291220364260
Pubmed

Levels of liver X receptors in testicular biopsies of patients with azoospermia.

NR1H3 NR1H2

6.77e-06291224842676
Pubmed

CD81 interacts with the T cell receptor to suppress signaling.

CD9 CD81

6.77e-06291223226274
Pubmed

Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.

NR1H3 NR1H2

6.77e-06291217108812
Pubmed

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.

NR1H3 NR1H2

6.77e-06291219292929
Pubmed

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.

NR1H3 NR1H2

6.77e-06291221134374
Pubmed

Lack of association between LXRα and LXRβ gene polymorphisms and prevalence of metabolic syndrome: a case-control study of an Iranian population.

NR1H3 NR1H2

6.77e-06291224100084
Cytoband12q13.3

LRP1 PFKM ANKRD52

1.42e-045190312q13.3
GeneFamilyNuclear hormone receptors

NR1H3 NR1H2 NR5A1 AR

1.36e-054954471
GeneFamilyLow density lipoprotein receptors

LRP1 LRP6

6.69e-0413542634
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA3 GATA4

8.97e-041554282
GeneFamilyCD molecules|Mucins

MUC5B MUC2

1.77e-0321542648
GeneFamilyCD molecules|Tetraspanins

CD9 CD81

4.36e-0333542768
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SUV39H1 PRDM6

4.62e-0334542487
GeneFamilyLIM domain containing

MICAL1 CSRP2

1.34e-02595421218
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

5.30e-08181847091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCellP28-Mesenchymal|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 FN1 ADAMTS2 LRP1 NR1H3 CD81 PRDM6

5.50e-0818284769f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

6.15e-0818584746460e74cc613df9043f5404e7342aa13cc34873
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 FN1 ADAMTS2 LRP1 NR1H3 CD81 PRDM6

6.86e-08188847f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1 CD81

7.38e-0819084747077579496c5340e99f61499427a3a36b566da3
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1 CD81

7.65e-08191847a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1 CD81

7.65e-0819184719c67a812b8ce97472d316acd15aeefe8736000d
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

8.21e-081938474c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

8.21e-08193847ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCellP03-Mesenchymal|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

8.81e-081958476180309c6ae278b996fd98c57461cbc129c028ba
ToppCellE17.5-Mesenchymal|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 ADAMTS2 NR1H3 CD81 PRDM6

9.12e-08196847b4ee991445b612506372b9361ebfe72cb59b811e
ToppCellPND10-Mesenchymal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

9.12e-08196847ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 CD81 PRDM6

9.12e-08196847f47e551ba484687ba6ce8c29a085106131364042
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 LRP1 PRDM6

1.05e-07200847e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 LRP1 PRDM6

1.05e-0720084734f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

SLIT2 FBN1 FN1 ADAMTS2 LRP1 POLR3A

6.63e-07163846f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MICAL1 KLHDC7B NR1H3 NOTCH1 DMXL1 ADH4

9.72e-07174846d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP MARVELD1 CD9 CSRP2 CD81 C16orf89

1.07e-061778466f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.11e-061788465cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCellfacs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.11e-06178846f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.11e-06178846ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.11e-06178846ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.11e-0617884687b04753650e45f12299c8456fb980d6c0d5961c
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.18e-06180846178648429686e6d4e6f3aafc350130e819788ecf
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.18e-06180846fcd5d5bf00ee728162b0aac4c81eb78e742cf6f2
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.18e-06180846c2a8f61c806f6f6f47743e9f7c9700705db43386
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.22e-0618184672c28baf4fd417ff4a7068603830d55074960144
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.22e-061818462ac4d3e8987d5a009d7908d8787e18165826202a
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWA3A SLIT2 FRAS1 FBN1 FN1 PRDM6

1.22e-061818469ede19228ba5c0668a9c06c915510b95585216ef
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CD9 CSRP2 GATA3 CD81 C16orf89

1.22e-061818462628c7ac345eaaeecf8e34617e81948925962cb9
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPM6A FN1 CD9 CSRP2 WSCD2 UGT2B28

1.22e-06181846beb2771820956be8b190c0088ae3c4efdb53c897
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 LRP1 CD81 PRDM6

1.43e-0618684688e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 PRDM6

1.48e-0618784692d468dde81125d51daf7abd4703741abe1ab91c
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.57e-06189846bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.62e-06190846bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.62e-06190846e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.62e-06190846ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.62e-06190846f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 LRP1

1.62e-06190846c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 PRDM6

1.67e-061918469431ffd6b758f756609d9057de2023596e22b5d4
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.67e-06191846094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.67e-06191846ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.67e-06191846997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.72e-06192846dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.72e-06192846ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCellP03-Mesenchymal-mesenchymal_fibroblast|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81

1.72e-06192846e79f2253e084a9ab9afcaf7ec42a5012ade42d36
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.72e-06192846deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCellPND28-Mesenchymal-Mesenchymal_structural|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.77e-06193846ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SFRP2 FBN1 FN1 ADAMTS2 LRP1 ADH4

1.77e-06193846dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.77e-06193846fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SELP CD9 CSRP2 GATA3 NOTCH1 C16orf89

1.77e-061938465f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 PRDM6

1.77e-06193846acad568621ed677031797b8c2e34dafea798d681
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.77e-0619384630481fb01c7acf85beae10213f038da86bed6777
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SFRP2 FBN1 FN1 ADAMTS2 LRP1 ADH4

1.77e-06193846e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SLIT2 FBN1 FN1 LRP1 CD81 PRDM6

1.83e-061948464f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.83e-0619484660622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 PRDM6

1.83e-0619484635f132cc38ac133be01834ed0946188aa0757eb4
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 FBN1 ADAMTS2 LRP1 PRDM6 ADH4

1.83e-0619484689b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCellPND01-Mesenchymal-Mesenchymal_structural|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81

1.88e-061958466bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCellP07-Mesenchymal|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.88e-06195846859764b605866b6c3e6edd0698670ca9c0f20745
ToppCellfacs-Bladder-nan-3m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FBN1 FN1 ADAMTS2 CSRP2 PRDM6

1.88e-06195846223f5f07dc28fa13a09bb589884c58043c7928c7
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81

1.88e-06195846a3b468125e48f072255cede7645f6692298ecf54
ToppCellPCW_07-8.5-Mesenchymal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLIT2 SFRP2 FBN1 FN1 LRP1 PRDM6

1.94e-061968468e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLIT2 FN1 ADAMTS2 LRP1 CD81 PRDM6

1.94e-061968461450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellPND07-Mesenchymal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 CD81 PRDM6

1.94e-061968460050c7134473fbfd7b9f0ae8d6d337713e60b57d
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81

2.00e-0619784606a0d7062dadda656decaf77dcef9a10b5f2698d
ToppCellPND03-Mesenchymal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 CD81 PRDM6

2.00e-06197846e3053ef8f604b6892c21c03e12612b49d3d30f23
ToppCellPND01-Mesenchymal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

2.00e-06197846292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLIT2 FBN1 FN1 LRP1 CD81 PRDM6

2.00e-0619784673a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCellPND14-Mesenchymal|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 FN1 ADAMTS2 LRP1 CD81 PRDM6

2.00e-061978469a14bc2e7d6081e2ab0e2e5555fc8804f13d3dbe
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SFRP2 FBN1 FN1 ADAMTS2 LRP1 ADH4

2.00e-061978464cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 LRP1 CD81

2.00e-06197846d35c7a36135b5ed6a7bf2f934849678eba2a0177
ToppCellMesenchymal_cells-Arteriolar_fibro.|Mesenchymal_cells / Lineage and Cell class

FN1 CD9 ADAMTS2 CSRP2 LRP1 CD81

2.00e-06197846cb321836980e7b4efbb9284c6af7ccd34079d2be
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP2 FN1 ADAMTS2 CSRP2 CD81 PRDM6

2.06e-061988468f202ed4692ea2c139ff05d4805c704ee4be095c
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLIT2 FBN1 FN1 ADAMTS2 LRP1 PRDM6

2.06e-061988463ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLIT2 SFRP2 FBN1 FN1 PEG10 CSRP2

2.06e-061988469541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

SLIT2 FRAS1 FBN1 FN1 ADAMTS2 PRDM6

2.06e-06198846df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellE18.5-Mesenchymal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT2 FBN1 FN1 ADAMTS2 CD81 PRDM6

2.06e-06198846a16aa41eab2e297e56de43c22c355df0f79315da
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

SLIT2 FRAS1 FBN1 FN1 CD81 PRDM6

2.12e-061998465b9d355795dd03a22f0961dfd143425c367a4654
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 CD9 PIEZO1 GATA3 KLHDC7B CD81

2.12e-061998465059a1d4df7d9989c922007a8dcba98b1f5687d5
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

SLIT2 SFRP2 FBN1 FN1 LRP1 C16orf89

2.12e-06199846f19c683f38bca3bfee40396f27423441051dec67
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLIT2 FBN1 DHCR7 LRP1 LRP6 SLC39A14

2.12e-061998468b86c69aaf60feff53aa782559cfece7342a23de
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP2 FBN1 FN1 LRP1 SLC39A14 PRDM6

2.12e-06199846abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 SFRP2 FBN1 ADAMTS2 LRP1 SLC39A14

2.18e-06200846ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FBN1 FN1 ADAMTS2 LRP1 PRDM6

2.18e-06200846389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLIT2 SFRP2 FBN1 FN1 LRP1 C16orf89

2.18e-062008466f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP2 FBN1 FN1 LHFPL3 LRP1 PRDM6

2.18e-062008468ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellwk_20-22-Mesenchymal-Fibroblast-intermediate_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SLIT2 FBN1 FN1 ADAMTS2 PEG10 LRP1

2.18e-06200846d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 SFRP2 FBN1 ADAMTS2 LRP1 PRDM6

2.18e-06200846b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellParenchymal-10x3prime_v2-Stromal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 SFRP2 FBN1 FN1 CSRP2 LRP1

2.18e-06200846f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FBN1 FN1 ADAMTS2 LRP1 PRDM6

2.18e-06200846cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLIT2 FBN1 FN1 LRP1 CD81 ADH4

2.18e-0620084644a68bacdb3d5bf563bd35952176995850933a81
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLIT2 SFRP2 FBN1 FN1 LRP1 C16orf89

2.18e-062008463a164e3971bcd62b148b813171c103adb81f972e
ToppCellSkin-Fibroblasts|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

SLIT2 SFRP2 FBN1 FN1 ADAMTS2 LRP1

2.18e-06200846f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FBN1 FN1 ADAMTS2 LRP1 PRDM6

2.18e-06200846cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 SFRP2 FBN1 FN1 LRP1 PRDM6

2.18e-06200846c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SFRP2 FBN1 FN1 ADAMTS2 LRP1 SLC39A14

2.18e-0620084674ad0ae592252060ee294d7483327d765a6ba1dd
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 FBN1 FN1 ADAMTS2 LRP1 PRDM6

2.18e-06200846311fab076f2ceb258e3970eb21e39344b894042a
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLIT2 FBN1 FN1 LRP1 CD81 ADH4

2.18e-06200846dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellwk_15-18-Mesenchymal-Fibroblast-intermediate_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SLIT2 FN1 ADAMTS2 PEG10 LRP1 AR

2.18e-062008466461d25fd8fb52921b188f083fbe808535d3130b
ComputationalMetal / Ca ion binding.

SLIT2 FBN1 PRF1 LRP1 CRB1 ADH4

5.09e-05133546MODULE_324
Diseaseaortic aneurysm

FBN1 LRP1

3.55e-0410842EFO_0001666
Diseasemembranoproliferative glomerulonephritis (biomarker_via_orthology)

FN1 PRF1

3.55e-0410842DOID:2920 (biomarker_via_orthology)
Disease46,XY partial gonadal dysgenesis

GATA4 NR5A1

4.33e-0411842C4510744
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

GATA4 LRP1

5.19e-0412842DOID:3827 (implicated_via_orthology)
DiseaseLiver carcinoma

GPM6A SLIT2 CELSR3 NR1H2 TST AR ADH4

6.15e-04507847C2239176
Diseasecholangiocarcinoma (is_marker_for)

MUC5B MUC2 NOTCH1

8.18e-0464843DOID:4947 (is_marker_for)
DiseaseAutistic Disorder

BTD PRF1 DHCR7 AR SHANK3

9.11e-04261845C0004352
DiseaseAlcohol abuse

FN1 GATA4 ADH4

9.35e-0467843C0085762
Diseasepre-malignant neoplasm (biomarker_via_orthology)

SUV39H1 MUC2

1.06e-0317842DOID:0060071 (biomarker_via_orthology)
Diseasebehavior or behavioral disorder measurement, personality trait

GPM6A WSCD2

1.19e-0318842EFO_0004365, EFO_0004782
Diseaseunipolar depression, bipolar disorder, schizophrenia

ADAMTS2 CSRP2

1.47e-0320842EFO_0003761, MONDO_0004985, MONDO_0005090
DiseaseGlioblastoma

FN1 CD9 NOTCH1

1.51e-0379843C0017636
Diseasedisease of metabolism (implicated_via_orthology)

PFKM YTHDF3

1.62e-0321842DOID:0014667 (implicated_via_orthology)
DiseaseGiant Cell Glioblastoma

FN1 CD9 NOTCH1

1.80e-0384843C0334588
Diseasecongenital heart disease (is_implicated_in)

GATA4 NOTCH1

2.12e-0324842DOID:1682 (is_implicated_in)
Diseaseobesity (is_implicated_in)

NR1H3 NR1H2 AR

2.26e-0391843DOID:9970 (is_implicated_in)
DiseaseCerebral Astrocytoma

AR NOTCH1

2.30e-0325842C0750935
DiseaseIntracranial Astrocytoma

AR NOTCH1

2.30e-0325842C0750936
DiseasePilocytic Astrocytoma

AR NOTCH1

2.30e-0325842C0334583
DiseaseAstrocytoma

AR NOTCH1

2.30e-0325842C0004114
DiseaseJuvenile Pilocytic Astrocytoma

AR NOTCH1

2.30e-0325842C0280783
DiseaseDiffuse Astrocytoma

AR NOTCH1

2.30e-0325842C0280785
DiseaseGrade I Astrocytoma

AR NOTCH1

2.30e-0325842C1704230
DiseaseSubependymal Giant Cell Astrocytoma

AR NOTCH1

2.30e-0325842C0205768
DiseaseMixed oligoastrocytoma

AR NOTCH1

2.30e-0325842C0547065
DiseaseChildhood Cerebral Astrocytoma

AR NOTCH1

2.30e-0325842C0338070
DiseaseGemistocytic astrocytoma

AR NOTCH1

2.49e-0326842C0334581
DiseaseProtoplasmic astrocytoma

AR NOTCH1

2.49e-0326842C0334580
DiseaseFibrillary Astrocytoma

AR NOTCH1

2.49e-0326842C0334582
DiseaseAnaplastic astrocytoma

AR NOTCH1

2.68e-0327842C0334579

Protein segments in the cluster

PeptideGeneStartEntry
CGTGIISLFCAHYAR

PRMT2

146

P55345
GCSGYCLSHQLLFFL

C16orf89

191

Q6UX73
CLLGCGFSTGYGAAI

ADH4

176

P08319
GATVFGSLDCYHGLC

AADACL4

121

Q5VUY2
NAFGNTALHIACYLG

ANKRD52

236

Q8NB46
LAYCLACGGGHLLPY

DHCR7

416

Q9UBM7
FLPNDCLLYGGDCSH

DMXL1

271

Q9Y485
GFLGCYGAIQESQCL

CD81

76

P60033
GGRTCSGLAYDFQLC

ADAMTS2

596

O95450
CLGTCVAYGDGHFIT

MUC5B

891

Q9HC84
SGFHYNVLSCEGCKG

NR1H3

106

Q13133
HCQHGGICLNLPGSY

NOTCH2NLB

191

P0DPK3
NGLLCHILDYSFGGG

NOTCH1

1421

P46531
VHSCGLGFYQAGSLC

FRAS1

451

Q86XX4
LCHGSAGNAYAFLTL

LANCL1

321

O43813
LYAGVALFCGCGHEA

GPM6A

36

P51674
GGHKCACPTNFYLGS

LRP1

3311

Q07954
FRNHTCGLCGDYNGL

MUC2

161

Q02817
HCGYLALVTSLSCGA

PFKM

211

P08237
YHARCLPHLGGGTCL

PRF1

521

P14222
CGFLGIYHLGAASAL

PNPLA4

11

P41247
GCGLSLATSGRCYHL

IL27RA

531

Q6UWB1
KLNLCLYCGTGGHYA

PEG10

291

Q86TG7
FCTGSGLGCHYLHLD

LMLN2

456

A0A1B0GTW7
NGGCSHLCLYRPQGL

LRP6

596

O75581
AGAGDLCALCGEHLY

MICAL1

691

Q8TDZ2
QGQGGLHGIYLRAFC

TUBGCP4

76

Q9UGJ1
LICGDEASGCHYGAL

AR

561

P10275
GLAGCRLCHYVCGVS

LTB4R

86

Q15722
GCATQHFLYLCLGGA

OR2AE1

96

Q8NHA4
CGYCGRAFAGATTLN

PRDM6

531

Q9NQX0
CGSHLCVVSLFYGTG

OR7D4

241

Q8NG98
RDGTGHYLCNACGLY

GATA3

276

P23771
TFGGKCYNCGQIGHL

ERVK-10

541

P87889
TFGGKCYNCGQIGHL

ERVK-19

541

Q9YNA8
DGTGHYLCNACGLYH

GATA4

231

P43694
TFGGKCYNCGQIGHL

ERVK-21

541

P62683
TFGGKCYNCGQIGHL

ERVK-24

541

P63145
TFGGKCYNCGQIGHL

ERVK-7

541

P63130
TFGGKCYNCGQIGHL

ERVK-8

541

P62685
TFGGKCYNCGQIGHL

ERVK-9

541

P63126
TFGGKCYNCGQIGHL

HERVK_113

541

P62684
IHYALNCCGLAGGVE

CD9

146

P21926
GGNKCGACGRTVYHA

CSRP2

6

Q16527
TGCGRCLANGGIHYI

FCGBP

4851

Q9Y6R7
GNALVCTCYGGSRGF

FN1

71

P02751
ICGGASCHNTLGSYK

FBN1

2616

P35555
FLCGCYVVALGAHTG

BTD

31

P43251
CLAGALLGDCVGSFY

ADPRS

26

Q9NX46
ATYGCGHCGALYAAL

FIZ1

356

Q96SL8
LAAAVCGGVCHGLYL

MARVELD1

141

Q9BSK0
CGGVCHGLYLLSALY

MARVELD1

146

Q9BSK0
HCASALGLGCYVAAA

IFRD2

246

Q12894
YGSICSFHCLEGQLL

SELP

726

P16109
EAHGGYTFCGLAALV

FNTB

246

P49356
ALDGHLYAIGGECLN

KLHDC7A

586

Q5VTJ3
GCGLCTMHNYLFLAG

KLHDC7B

346

Q96G42
AFHYLHAGLCGLQGL

CELSR3

2751

Q9NYQ7
CLHGGLCVDGENRYS

CRB1

271

P82279
CGFTSAGHVLCGYPL

SCNN1D

66

P51172
AGHVLCGYPLCLLSG

SCNN1D

71

P51172
GHFVLSCSYDGLDCQ

SCNN1D

421

P51172
ACCCYLGLAFGILAG

SLC39A14

406

Q15043
CYHPIFCGNLSGGDL

FER1L6

936

Q2WGJ9
HCCLGSARGLFLFGQ

SFRP2

16

Q96HF1
SGYHYGLLTCESCKG

NR5A1

21

Q13285
GVTACHVALGAYLCG

MPST

251

P25325
GLLFVCLHCALSYQG

TMEM150A

151

Q86TG1
CGSHLSIVLLFYGAG

OR7G2

241

Q8NG99
GFHYNVLSCEGCKGF

NR1H2

96

P55055
TCGKNLADCLGHYGY

POLR3A

71

O14802
TGGCCPGASLHKFAY

SUV39H1

191

O43463
TFGGKCYNCGQIGHL

ERVK-9

541

P63128
YNHAACFGLQPGCLL

NLN

446

Q9BYT8
LYLLFSVNGSGHFCG

YTHDF3

461

Q7Z739
GCGLCGQSFAGAYDL

ZNF865

821

P0CJ78
DCGKACGGFYLLNEH

ZNF778

341

Q96MU6
CGEGTFGQLCRHYGD

ELAC2

516

Q9BQ52
HIFLAGCTGGFLQAY

SLC25A45

101

Q8N413
YHSALGGGDALCCEL

SHANK3

221

Q9BYB0
GFLIGAGIAAYLACH

PLPPR3

266

Q6T4P5
AGIAAYLACHAVGNF

PLPPR3

271

Q6T4P5
CNTPGGFLLHYCLLA

SLCO4C1

101

Q6ZQN7
FSYSCKCLEGHGGVL

SLIT2

1391

O94813
HSSQRYCGVCLGLLA

TMEM82

181

A0PJX8
YCGVCLGLLAHAHGL

TMEM82

186

A0PJX8
GALYCLLGNHSGVCL

PSME4

1026

Q14997
VLLGNICYNCGRSGH

ZCCHC13

61

Q8WW36
ALSQHCYAGSGCPLL

SCGB2A2

11

Q13296
GCSFLNCYITFDAGH

ZNF442

126

Q9H7R0
ALCATGAQGLYFHIG

TMED4

21

Q7Z7H5
AVGCFGAGHLICLYC

PIEZO1

251

Q92508
GGLEFGAECYCGHKI

WSCD2

171

Q2TBF2
GVTACHVALAAYLCG

TST

251

Q16762
LIHLGCYFSSGSCGK

UGT2B28

11

Q9BY64
KYGHAACFGLQPGCL

THOP1

421

P52888
GGCDLQLNVCLFYVG

VWA3A

636

A6NCI4
YLNGGTCACFEILGF

TTLL13

361

A6NNM8
FHYCIGNGFSRELTC

LHFPL3

76

Q86UP9