Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	mandibular retrognathia	COL27A1 CASK	5.74e-06	2	34	2	MP:0030273
MousePheno	increased insulin sensitivity	KMT2D IKBKE CNOT3 CRTC2 ZBTB22	8.46e-05	188	34	5	MP:0002891
MousePheno	retrognathia	COL27A1 CASK	1.20e-04	7	34	2	MP:0004282
MousePheno	decreased body fat mass	KMT2D CNOT3 ZBTB22	1.86e-04	46	34	3	MP:0014143
Domain	MAD_homology1_Dwarfin-type	NFIC SMAD5	2.63e-04	12	38	2	IPR003619
Domain	DWA	NFIC SMAD5	2.63e-04	12	38	2	SM00523
Domain	MH1	NFIC SMAD5	2.63e-04	12	38	2	PF03165
Domain	SH3	FYB1 EFS ARHGAP26 CASK	9.44e-04	216	38	4	PS50002
Domain	SH3	FYB1 EFS ARHGAP26 CASK	9.44e-04	216	38	4	SM00326
Domain	SH3_domain	FYB1 EFS ARHGAP26 CASK	1.01e-03	220	38	4	IPR001452
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2D TAF3 SIN3A SNAI1 UBN1 RAPH1 ZNF592 NFIC CNOT3 POLR2A YLPM1	7.94e-10	774	40	11	15302935
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	PPARGC1B SIN3A SNAI1 ZNF592 RFX4 NFIC CNOT3 POLR2A SMAD5 ZBTB22	4.22e-08	877	40	10	20211142
Pubmed	Human transcription factor protein interaction networks.	ZFHX3 ARID1B KMT2D TAF3 SIN3A UBN1 ZNF592 NFIC CNOT3 PIP4P1 SMAD5 YLPM1	4.24e-08	1429	40	12	35140242
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	ARID1B KMT2D SIN3A NFIC RSBN1L POLR2A YLPM1	1.16e-07	341	40	7	32971831
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ARID1B KMT2D TAF3 SIN3A RAPH1 RSBN1L POLR2A YLPM1	1.81e-07	549	40	8	38280479
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF469 SIN3A NUP155 UBN1 PIP4P1 CRTC2 YLPM1	5.51e-07	430	40	7	35044719
Pubmed	IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis.	SNAI1 IKBKE	1.29e-06	2	40	2	35066576
Pubmed	Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation.	SNAI1 IKBKE	1.29e-06	2	40	2	34741724
Pubmed	Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.	SNAI1 POLR2A SMAD5	1.58e-06	20	40	3	30898767
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARID1B KMT2D FCHO2 NUP155 RAPH1 PPFIA1 POLR2A YLPM1 CASK	2.35e-06	1049	40	9	27880917
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	KMT2D JPH3 CASK	2.46e-06	23	40	3	9225980
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZFHX3 ZNF469 ARID1B TAF3 SIN3A ZNF592 RSBN1L PPFIA1 POLR2A	3.90e-06	1116	40	9	31753913
Pubmed	Functional proteomics mapping of a human signaling pathway.	ARID1B KMT2D NUP155 ZNF592 SMAD5 YLPM1 CASK	4.53e-06	591	40	7	15231748
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	KMT2D FCHO2 NUP155 FAM168A FYB1 NFIC CASK	5.22e-06	604	40	7	38803224
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ZFHX3 ARID1B KMT2D SIN3A YLPM1	5.32e-06	220	40	5	35785414
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	FCHO2 NUP155 YLPM1	6.19e-06	31	40	3	22323290
Pubmed	BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.	NFIC POLR2A	7.73e-06	4	40	2	15999204
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	ARID1B KMT2D NUP155 NFIC CRTC2 YLPM1	1.31e-05	457	40	6	32344865
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ARID1B KMT2D SIN3A NFIC YLPM1	1.38e-05	268	40	5	33640491
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TAF3 SIN3A NUP155 UBN1 ZNF592 NFIC POLR2A YLPM1	1.71e-05	1014	40	8	32416067
Pubmed	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.	SIN3A SNAI1	1.93e-05	6	40	2	14673164
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D POLR2A	1.93e-05	6	40	2	16199523
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	ARID1B KMT2D	1.93e-05	6	40	2	8896557
Pubmed	Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge.	SNAI1 SMAD5	2.70e-05	7	40	2	18003744
Pubmed	Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.	UBN1 POLR2A	3.60e-05	8	40	2	22195966
Pubmed	A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.	SIN3A SNAI1	3.60e-05	8	40	2	28892081
Pubmed	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.	FAM168A RAPH1 CASK	4.61e-05	60	40	3	19075228
Pubmed	Interaction network of human early embryonic transcription factors.	ZFHX3 ARID1B KMT2D TAF3 NFIC	5.01e-05	351	40	5	38297188
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZFHX3 SIN3A NUP155 ZNF592 NFIC POLR2A	5.11e-05	583	40	6	29844126
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NUP155 NFIC CRTC2 YLPM1	5.48e-05	180	40	4	35198878
Pubmed	Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.	PPFIA1 CASK	5.77e-05	10	40	2	18054859
Pubmed	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.	SIN3A POLR2A	5.77e-05	10	40	2	11238380
Pubmed	Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.	SIN3A SNAI1	5.77e-05	10	40	2	25314079
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	ARID1B NUP155 FAM168A WASF2 POLR2A EZHIP	6.87e-05	615	40	6	31048545
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SIN3A RAPH1 RSBN1L WASF2 KIAA1217 POLR2A YLPM1	8.47e-05	934	40	7	33916271
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ARID1B TAF3 UBN1 FAM168A RSBN1L POLR2A YLPM1	9.67e-05	954	40	7	36373674
Pubmed	A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics.	SNAI1 POLR2A	9.98e-05	13	40	2	31928974
Pubmed	The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.	KMT2D PRR36	9.98e-05	13	40	2	36395886
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PRR36 WASF2 KIAA1217 PPFIA1 YLPM1 CASK ZBTB22	1.02e-04	963	40	7	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZFHX3 KMT2D RAPH1 ZNF592 PPFIA1	1.14e-04	418	40	5	34709266
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	FCHO2 NUP155 KIAA1217 PPFIA1 CASK	1.18e-04	421	40	5	36976175
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SIN3A ZNF592 NFIC RSBN1L POLR2A YLPM1 EZHIP	1.21e-04	989	40	7	36424410
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID1B KMT2D NFIC	1.21e-04	83	40	3	28794006
Pubmed	Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.	ARID1B SIN3A	1.34e-04	15	40	2	17255939
Pubmed	Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.	KMT2D POLR2A	1.34e-04	15	40	2	14992727
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ARID1B NUP155 ZNF592 POLR2A YLPM1	1.45e-04	440	40	5	34244565
Pubmed	Transcriptional activators differ in their abilities to control alternative splicing.	NFIC POLR2A	1.53e-04	16	40	2	12221105
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FCHO2 RAPH1 CNOT3 KIAA1217 POLR2A CRTC2 SMAD5	1.63e-04	1038	40	7	26673895
Pubmed	Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.	SNAI1 SMAD5	1.95e-04	18	40	2	22912414
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ARID1B FCHO2 RAPH1 NFIC POLR2A	2.00e-04	472	40	5	38943005
Pubmed	Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.	SNAI1 SMAD5	2.18e-04	19	40	2	27056911
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	PPFIA1 CASK	2.42e-04	20	40	2	23791195
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ZNF592 IKBKE RSBN1L PPFIA1 POLR2A	2.54e-04	497	40	5	36774506
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZFHX3 ZNF592 CNOT3 RSBN1L WASF2 PPFIA1 POLR2A CASK	2.60e-04	1497	40	8	31527615
Pubmed	Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.	SNAI1 SMAD5	2.67e-04	21	40	2	23055936
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	MYO16 ARHGAP26	2.94e-04	22	40	2	21946561
Pubmed	Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.	SNAI1 SMAD5	3.21e-04	23	40	2	16314491
Pubmed	Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition.	SNAI1 SMAD5	3.21e-04	23	40	2	35998584
Pubmed	The functional interactome landscape of the human histone deacetylase family.	SIN3A ZNF592 POLR2A YLPM1	3.37e-04	289	40	4	23752268
Pubmed	The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.	TAF3 POLR2A	3.80e-04	25	40	2	19240132
Pubmed	The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling.	SNAI1 SMAD5	3.80e-04	25	40	2	33846290
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SNAI1 RFX4 NFIC SMAD5 ZBTB22	3.85e-04	544	40	5	28473536
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	KMT2D NFIC PPFIA1 ARHGAP26 POLR2A	4.11e-04	552	40	5	10737800
Pubmed	Bmp2 and Notch cooperate to pattern the embryonic endocardium.	SNAI1 SMAD5	4.12e-04	26	40	2	29853617
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	PPFIA1 CASK	4.12e-04	26	40	2	17124501
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	SIN3A NUP155 CNOT3 WASF2 CASK	4.39e-04	560	40	5	35241646
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	FCHO2 FYB1 WASF2 PPFIA1 CASK	4.72e-04	569	40	5	30639242
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	ARID1B IKBKE	4.78e-04	28	40	2	30037996
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	PPFIA1 CASK	5.50e-04	30	40	2	16186258
Pubmed	A census of human transcription factors: function, expression and evolution.	ZFHX3 KMT2D SNAI1 RFX4 NFIC SMAD5	5.60e-04	908	40	6	19274049
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2D POLR2A	5.87e-04	31	40	2	20516061
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	UBN1 POLR2A	5.87e-04	31	40	2	23602572
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RNF167 RAPH1 NFIC CNOT3 PPFIA1 CASK	6.17e-04	925	40	6	28986522
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	TAF3 SIN3A UBN1 ZNF592 NFIC	6.37e-04	608	40	5	36089195
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	SIN3A KIAA1217 POLR2A	6.39e-04	146	40	3	23892456
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	ARID1B SIN3A ZNF592	6.91e-04	150	40	3	28242625
Pubmed	Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.	SNAI1 SMAD5	7.07e-04	34	40	2	21311046
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	ZFHX3 NUP155 NFIC	7.18e-04	152	40	3	28192407
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WASF2 POLR2A YLPM1	7.46e-04	154	40	3	16055720
Pubmed	β-Catenin regulates endocardial cushion growth by suppressing p21.	SNAI1 SMAD5	7.49e-04	35	40	2	37385754
Pubmed	Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.	SNAI1 SMAD5	7.49e-04	35	40	2	29540665
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	RAPH1 KIAA1217 POLR2A CASK	7.77e-04	361	40	4	30344098
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	ARID1B KMT2D SIN3A	7.89e-04	157	40	3	30186101
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	NUP155 PPFIA1 POLR2A YLPM1	8.01e-04	364	40	4	24778252
Pubmed	USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.	FCHO2 KIAA1217	8.37e-04	37	40	2	32133736
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	NUP155 FYB1 CNOT3 POLR2A	8.51e-04	370	40	4	22922362
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SIN3A NUP155 RSBN1L WASF2 CRTC2	8.60e-04	650	40	5	38777146
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	ZFHX3 SIN3A	8.83e-04	38	40	2	33283408
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	RAPH1 WASF2 PPFIA1 CASK	9.12e-04	377	40	4	38117590
Pubmed	Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.	TAF3 POLR2A	9.30e-04	39	40	2	9054383
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2D SIN3A POLR2A	9.43e-04	167	40	3	20362541
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	WASF2 CRTC2	1.08e-03	42	40	2	23444366
Pubmed	A GO catalogue of human DNA-binding transcription factors.	ZNF469 ZNF592	1.08e-03	42	40	2	34673265
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	RSBN1L PPFIA1	1.08e-03	42	40	2	26362536
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	ZNF592 KIAA1217 POLR2A	1.11e-03	177	40	3	26206133
Pubmed	Arid3b is essential for second heart field cell deployment and heart patterning.	SNAI1 SMAD5	1.13e-03	43	40	2	25336743
Interaction	NCK2 interactions	RAPH1 FYB1 EFS WASF2 KIAA1217 ARHGAP26 YLPM1	7.49e-07	262	40	7	int:NCK2
Interaction	TBR1 interactions	ZFHX3 ARID1B KMT2D NFIC CASK	2.85e-06	113	40	5	int:TBR1
Interaction	YAP1 interactions	ARID1B KMT2D TAF3 SIN3A SNAI1 IKBKE RSBN1L POLR2A PIP4P1 SMAD5 YLPM1	6.24e-06	1095	40	11	int:YAP1
Interaction	H3C1 interactions	ZFHX3 KMT2D TAF3 SIN3A SNAI1 UBN1 NFIC RSBN1L POLR2A EZHIP	7.57e-06	901	40	10	int:H3C1
Interaction	KDM1A interactions	ZFHX3 KMT2D SIN3A SNAI1 RAPH1 ZNF592 CNOT3 KIAA1217 PPFIA1 POLR2A	1.11e-05	941	40	10	int:KDM1A
Interaction	CREBBP interactions	ARID1B KMT2D SIN3A SNAI1 ZNF592 NFIC CNOT3 POLR2A	1.93e-05	599	40	8	int:CREBBP
Interaction	EGR2 interactions	ZFHX3 ARID1B KMT2D SNAI1 NFIC	2.15e-05	171	40	5	int:EGR2
Interaction	EPAS1 interactions	ZFHX3 ARID1B SIN3A SNAI1 POLR2A	2.27e-05	173	40	5	int:EPAS1
Interaction	PAX2 interactions	ARID1B KMT2D SNAI1 NFIC	2.40e-05	85	40	4	int:PAX2
Interaction	TEAD1 interactions	ZFHX3 ARID1B KMT2D SIN3A NFIC	2.47e-05	176	40	5	int:TEAD1
Interaction	SMAD3 interactions	ZFHX3 ARID1B SIN3A SNAI1 NFIC SMAD5 JPH3	2.49e-05	447	40	7	int:SMAD3
Interaction	GSC interactions	ZFHX3 ARID1B KMT2D NFIC	2.63e-05	87	40	4	int:GSC
Interaction	RCOR1 interactions	ZFHX3 KMT2D SIN3A SNAI1 RAPH1 ZNF592 PPFIA1	4.71e-05	494	40	7	int:RCOR1
Interaction	FEV interactions	ZFHX3 ARID1B KMT2D TAF3 NFIC	4.88e-05	203	40	5	int:FEV
Interaction	PAX6 interactions	ZFHX3 ARID1B KMT2D TAF3 NFIC SMAD5	7.85e-05	366	40	6	int:PAX6
Interaction	DDA1 interactions	TAF3 NUP155 ZNF592 NFIC POLR2A CRTC2	8.08e-05	368	40	6	int:DDA1
Interaction	KLF3 interactions	ZFHX3 ARID1B KMT2D TAF3 NFIC	8.45e-05	228	40	5	int:KLF3
Interaction	BHLHE40 interactions	ZFHX3 TAF3 SIN3A NUP155	8.96e-05	119	40	4	int:BHLHE40
Interaction	PAX7 interactions	ZFHX3 ARID1B KMT2D NFIC	1.05e-04	124	40	4	int:PAX7
Interaction	PAX9 interactions	ZFHX3 ARID1B KMT2D NFIC	1.26e-04	130	40	4	int:PAX9
Interaction	ASF1A interactions	ARID1B KMT2D UBN1 ZNF592 POLR2A	1.28e-04	249	40	5	int:ASF1A
Interaction	MEN1 interactions	ARID1B KMT2D SIN3A ZNF592 NFIC RSBN1L POLR2A SMAD5 YLPM1	1.48e-04	1029	40	9	int:MEN1
Interaction	NUP35 interactions	ARID1B KMT2D NUP155 NFIC CRTC2 YLPM1	1.75e-04	424	40	6	int:NUP35
Interaction	TLX2 interactions	ZFHX3 ARID1B KMT2D NFIC	1.77e-04	142	40	4	int:TLX2
Interaction	GPS2 interactions	SIN3A RFX4 NFIC PPFIA1	1.87e-04	144	40	4	int:GPS2
Interaction	ELF5 interactions	ARID1B KMT2D SIN3A POLR2A	2.02e-04	147	40	4	int:ELF5
Interaction	HNF4A interactions	PPARGC1B ARID1B KMT2D TAF3 UBN1	2.03e-04	275	40	5	int:HNF4A
Interaction	SMAD9 interactions	ARID1B KMT2D ZNF592 SMAD5	2.36e-04	153	40	4	int:SMAD9
Interaction	ACTL6A interactions	ARID1B SIN3A CNOT3 ARHGAP26 POLR2A	2.56e-04	289	40	5	int:ACTL6A
Interaction	SOX5 interactions	ZFHX3 KMT2D NFIC SMAD5	2.93e-04	162	40	4	int:SOX5
Interaction	EP300 interactions	ZNF469 KMT2D SIN3A SNAI1 UBN1 CNOT3 POLR2A CRTC2 SMAD5 YLPM1	3.15e-04	1401	40	10	int:EP300
Interaction	LHX4 interactions	ARID1B KMT2D NFIC WASF2	3.22e-04	166	40	4	int:LHX4
Interaction	SP7 interactions	ARID1B KMT2D SIN3A NFIC YLPM1	3.23e-04	304	40	5	int:SP7
Interaction	ARHGAP12 interactions	RAPH1 WASF2 YLPM1	3.32e-04	68	40	3	int:ARHGAP12
Interaction	ARRDC1 interactions	FAM168A PRR36 POLR2A	3.32e-04	68	40	3	int:ARRDC1
Interaction	KMT2D interactions	KMT2D NUP155 NFIC POLR2A	3.45e-04	169	40	4	int:KMT2D
Interaction	RELA interactions	ZFHX3 KMT2D SNAI1 IKBKE NFIC POLR2A	3.61e-04	485	40	6	int:RELA
Interaction	FOS interactions	ARID1B KMT2D SIN3A UBN1 NFIC	3.63e-04	312	40	5	int:FOS
Interaction	TLX1 interactions	ZFHX3 ARID1B KMT2D NFIC	3.93e-04	175	40	4	int:TLX1
Interaction	MYO16 interactions	MYO16 ARHGAP26	4.53e-04	16	40	2	int:MYO16
Interaction	LHX2 interactions	ZFHX3 ARID1B KMT2D NFIC	4.66e-04	183	40	4	int:LHX2
Interaction	SMARCD2 interactions	ARID1B SIN3A FAM168A NFIC	4.66e-04	183	40	4	int:SMARCD2
Interaction	DTX2 interactions	NUP155 FAM168A NFIC CRTC2 YLPM1	4.70e-04	330	40	5	int:DTX2
Interaction	LMAN1L interactions	FCHO2 ARHGAP26	5.13e-04	17	40	2	int:LMAN1L
Interaction	HNF1B interactions	ZFHX3 ARID1B KMT2D UBN1	5.36e-04	190	40	4	int:HNF1B
Interaction	SOX7 interactions	ARID1B KMT2D SMAD5	5.75e-04	82	40	3	int:SOX7
Interaction	CABIN1 interactions	SIN3A UBN1 POLR2A	5.96e-04	83	40	3	int:CABIN1
Interaction	NFE2 interactions	KMT2D SNAI1 ZNF592	6.17e-04	84	40	3	int:NFE2
Interaction	FBXO22 interactions	SNAI1 ZNF592 IKBKE RSBN1L PPFIA1 POLR2A	6.37e-04	540	40	6	int:FBXO22
Interaction	SMARCC2 interactions	ARID1B SIN3A UBN1 POLR2A YLPM1	6.37e-04	353	40	5	int:SMARCC2
Interaction	GATA2 interactions	ZFHX3 ARID1B KMT2D NFIC	6.38e-04	199	40	4	int:GATA2
Interaction	TULP4 interactions	FAM168A CASK	6.43e-04	19	40	2	int:TULP4
Interaction	DROSHA interactions	PPFIA1 SMAD5 YLPM1	6.84e-04	87	40	3	int:DROSHA
Interaction	DYRK1A interactions	KMT2D NUP155 CNOT3 RSBN1L KIAA1217 PPFIA1	7.14e-04	552	40	6	int:DYRK1A
Interaction	BCAR1 interactions	ZFHX3 FYB1 EFS PPFIA1 POLR2A CASK	7.42e-04	556	40	6	int:BCAR1
Interaction	SOX10 interactions	ARID1B KMT2D NFIC	8.05e-04	92	40	3	int:SOX10
Interaction	TLE3 interactions	ZFHX3 ARID1B KMT2D NFIC CRTC2	8.47e-04	376	40	5	int:TLE3
Interaction	SOX17 interactions	ARID1B KMT2D NFIC	8.84e-04	95	40	3	int:SOX17
Interaction	SMARCC1 interactions	ARID1B SIN3A UBN1 POLR2A YLPM1	9.30e-04	384	40	5	int:SMARCC1
Interaction	SOX9 interactions	ARID1B KMT2D NFIC	9.39e-04	97	40	3	int:SOX9
Interaction	CCNH interactions	CNOT3 PPFIA1 POLR2A	9.67e-04	98	40	3	int:CCNH
Interaction	ERG interactions	ARID1B KMT2D NFIC POLR2A	9.76e-04	223	40	4	int:ERG
Interaction	GLI2 interactions	SNAI1 CNOT3 ARHGAP26	9.96e-04	99	40	3	int:GLI2
Cytoband	5p13.1	NUP155 FYB1	1.12e-04	18	40	2	5p13.1
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D JPH3 CASK	9.25e-06	25	30	3	775
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	UBN1 MYO16 YLPM1	3.28e-03	181	30	3	694
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX3 ZNF469 SNAI1 ZNF592 ZBTB22	6.08e-03	718	30	5	28
GeneFamily	PHD finger proteins	KMT2D TAF3	9.74e-03	90	30	2	88
Coexpression	GSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA5_STIM_CD8_TCELL_UP	ZFHX3 RNF167 KMT2D FCHO2 UBN1 RAPH1	5.66e-07	200	40	6	M8050
Coexpression	GSE26343_UNSTIM_VS_LPS_STIM_MACROPHAGE_DN	ZFHX3 RAPH1 NFIC WASF2 POLR2A	1.30e-05	200	40	5	M8648
Computational	Neighborhood of PRKACA	ZNF592 IKBKE NFIC ZBTB22	2.17e-04	112	29	4	MORF_PRKACA
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	ZFHX3 RAPH1 PRR36 NFIC POLR2A	1.05e-06	104	40	5	ctd:C000595015
Disease	cortical surface area measurement	ZFHX3 ZNF469 ARID1B FCHO2 FAM168A RAPH1 EFS RFX4 MYO16 PPFIA1 SMAD5	8.73e-07	1345	39	11	EFO_0010736
Disease	AUTISM, SUSCEPTIBILITY TO, 15	SIN3A POLR2A	4.74e-05	8	39	2	C2677504
Disease	putamen volume change measurement	TAF3 MYO16	1.32e-04	13	39	2	EFO_0021495
Disease	factor VIII measurement, Ischemic stroke	FCHO2 JPH3	2.87e-04	19	39	2	EFO_0004630, HP_0002140
Disease	sexual dimorphism measurement	ZFHX3 RFLNA UBN1 ZNF592 NFIC ARHGAP26 POLR2A	5.48e-04	1106	39	7	EFO_0021796
Disease	Ischemic stroke, von Willebrand factor measurement	FCHO2 JPH3	7.23e-04	30	39	2	EFO_0004629, HP_0002140
Disease	caudate nucleus volume	ZFHX3 JPH3	7.23e-04	30	39	2	EFO_0004830
Disease	Severe Congenital Microcephaly	SIN3A CASK	7.73e-04	31	39	2	C3853041
Disease	apolipoprotein A 1 measurement	PPARGC1B RFLNA FAM168A RFX4 NFIC YLPM1	8.03e-04	848	39	6	EFO_0004614
Disease	lung non-small cell carcinoma (is_implicated_in)	ZFHX3 ARID1B KMT2D	8.26e-04	139	39	3	DOID:3908 (is_implicated_in)
Disease	Microlissencephaly	SIN3A CASK	8.76e-04	33	39	2	C1956147
Disease	triglyceride measurement, response to diuretic	MYO16 KIAA1217	9.30e-04	34	39	2	EFO_0004530, GO_0036270
Disease	FEV/FEC ratio	ZFHX3 PPARGC1B NFIC MYO16 ARHGAP26 JPH3 YLPM1	1.02e-03	1228	39	7	EFO_0004713
Disease	atrial fibrillation	ZFHX3 RFLNA ARHGAP26 POLR2A	1.43e-03	371	39	4	EFO_0000275
Disease	body surface area	ZFHX3 UBN1 NFIC RSBN1L ARHGAP26	1.51e-03	643	39	5	EFO_0022196
Disease	skin aging measurement	PPARGC1B UBN1 NFIC	1.76e-03	181	39	3	EFO_0008006
Disease	response to fenofibrate	PPARGC1B RFLNA	2.00e-03	50	39	2	GO_1901557
Disease	pulse pressure measurement	ZFHX3 ARID1B RAPH1 WASF2 KIAA1217 ARHGAP26 COL27A1	2.09e-03	1392	39	7	EFO_0005763
Disease	diet measurement	ZFHX3 ZNF469 ARID1B MYO16 KIAA1217 CRTC2	2.38e-03	1049	39	6	EFO_0008111
Disease	osteoarthritis	RAPH1 COL27A1 JPH3	3.14e-03	222	39	3	MONDO_0005178
Disease	cortical thickness	ZNF469 ARID1B UBN1 RFX4 MYO16 YLPM1	3.19e-03	1113	39	6	EFO_0004840
Disease	breast carcinoma (is_marker_for)	ZFHX3 KMT2D	3.46e-03	66	39	2	DOID:3459 (is_marker_for)
Disease	Microcephaly	SIN3A CASK	3.56e-03	67	39	2	C0025958
Disease	response to ketamine	ZFHX3 ARHGAP26	3.78e-03	69	39	2	EFO_0009748
Disease	mean reticulocyte volume	ZNF469 RFLNA RAPH1 MYO16 KIAA1217	3.86e-03	799	39	5	EFO_0010701

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFSPPVTSNTSPPPA	FCHO2	486	Q0JRZ9
PEYSSPSAPPPPPSQ	ARID1B	521	Q8NFD5
PTYPSGPPPAASALS	CNOT3	321	O75175
QPAFPASYIPPSPPT	RAPH1	816	Q70E73
PPSSPVSNPSPEYTG	RFX4	526	Q33E94
PPPTSPYLNGDSPES	CASK	461	O14936
VPPTQSNTAPPPYSP	FAM168A	111	Q92567
SNTAPPPYSPSPNPY	FAM168A	116	Q92567
PPAPYSPPSSRPLSS	MYO16	1656	Q9Y6X6
PLPPSSPGFRPSSYP	EZHIP	171	Q86X51
AQASPPPIAPYPSPT	IKBKE	661	Q14164
SYSTTSLPPPPPSHP	FYB1	386	O15117
IPPYPASSLASSSPP	PPFIA1	681	Q13136
SDPLGSPSPSPSPPY	ASIC3	296	Q9UHC3
SPVPSGSPYPNPSFL	NUP155	606	O75694
NPSPQDTYPGPTPPS	CRTC2	181	Q53ET0
PPPFTALSSSPAPTP	COL27A1	481	Q8IZC6
LSPASPAQPGSPYPA	EFS	76	O43281
PPYSPLTSPDSGSAP	PIP4P1	66	Q86T03
PPAAPSPQSYGSPAS	RSBN1L	71	Q6PCB5
PPNFPYISSPSVSPP	TAF3	486	Q5VWG9
QAPFSPPASPPVSPS	PRR36	896	Q9H6K5
NSLPPNPSPTSPLSP	ARHGAP26	661	Q9UNA1
FPGPSTDPPLSPPSS	RNF167	331	Q9H6Y7
SASPAPSSAPPSPAP	PPARGC1B	126	Q86YN6
RAPPPLSFSSSPPSP	KIAA1217	1886	Q5T5P2
PASQQTPPLPPYASP	SIN3A	261	Q96ST3
PTSPSYSPPDTSPAN	NFIC	471	P08651
PLSPNSPYPPSPASS	SMAD5	186	Q99717
QPPSPPSPAPSSFSS	SNAI1	101	O95863
PPSPSPSPPFYSLAP	RFLNA	31	Q6ZTI6
SPGSPGPSSPYIPSP	POLR2A	1571	P24928
TSGSASPPPPALPLY	ZNF592	686	Q92610
PPTSSQPYLPPAQPS	YLPM1	176	P49750
YPPPPQSDSASSPSP	WASF2	246	Q9Y6W5
YTSPSATPRPPAPGP	ZNF469	196	Q96JG9
PSPSAPPPASSLQSP	UBN1	721	Q9NPG3
GPTPSSYAPSHPPRP	ZBTB22	401	O15209
SPPPPSAAAPSSASP	ZFHX3	3596	Q15911
SPLSPPPESSPFSPL	KMT2D	501	O14686
PLQSFPTSPAATPPP	JPH3	476	Q8WXH2