| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | NEDD8 ligase activity | 7.03e-05 | 4 | 69 | 2 | GO:0061663 | |
| GeneOntologyMolecularFunction | ubiquitin-protein transferase activity | 2.20e-04 | 473 | 69 | 8 | GO:0004842 | |
| GeneOntologyMolecularFunction | zinc ion binding | RNF7 ZNF330 TRIM35 ENPP2 EHMT1 ADAMTS20 TRIM6 TRIM22 TRIM38 CXXC1 RBX1 | 2.24e-04 | 891 | 69 | 11 | GO:0008270 |
| GeneOntologyMolecularFunction | NEDD8 transferase activity | 2.44e-04 | 7 | 69 | 2 | GO:0019788 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase activity | 2.94e-04 | 372 | 69 | 7 | GO:0061630 | |
| GeneOntologyMolecularFunction | acyltransferase activity | RNF7 ZDHHC18 FBXO24 RNFT2 TRIM35 ZDHHC19 TRIM6 TRIM22 TRIM38 RBX1 | 3.13e-04 | 775 | 69 | 10 | GO:0016746 |
| GeneOntologyMolecularFunction | ubiquitin-like protein transferase activity | 3.75e-04 | 512 | 69 | 8 | GO:0019787 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase activity | 4.42e-04 | 398 | 69 | 7 | GO:0061659 | |
| GeneOntologyMolecularFunction | aminoacyltransferase activity | 4.83e-04 | 532 | 69 | 8 | GO:0016755 | |
| Domain | - | RNF7 TCF19 RNFT2 TRIM35 PHF24 HGS DIDO1 TRIM6 TRIM22 TRIM38 CXXC1 RBX1 | 5.83e-08 | 449 | 67 | 12 | 3.30.40.10 |
| Domain | Znf_RING/FYVE/PHD | RNF7 TCF19 RNFT2 TRIM35 PHF24 HGS DIDO1 TRIM6 TRIM22 TRIM38 CXXC1 RBX1 | 7.41e-08 | 459 | 67 | 12 | IPR013083 |
| Domain | Znf_RING_H2 | 1.27e-05 | 2 | 67 | 2 | IPR024766 | |
| Domain | zf-rbx1 | 1.27e-05 | 2 | 67 | 2 | PF12678 | |
| Domain | zf-C3HC4 | 1.49e-05 | 223 | 67 | 7 | PF00097 | |
| Domain | Zinc_finger_PHD-type_CS | 8.69e-05 | 65 | 67 | 4 | IPR019786 | |
| Domain | ZF_RING_2 | 9.41e-05 | 298 | 67 | 7 | PS50089 | |
| Domain | RING | 1.09e-04 | 305 | 67 | 7 | SM00184 | |
| Domain | BBOX | 1.10e-04 | 69 | 67 | 4 | SM00336 | |
| Domain | Butyrophylin | 1.16e-04 | 70 | 67 | 4 | IPR003879 | |
| Domain | - | 1.23e-04 | 71 | 67 | 4 | 4.10.45.10 | |
| Domain | zf-B_box | 1.30e-04 | 72 | 67 | 4 | PF00643 | |
| Domain | Znf_RING | 1.64e-04 | 326 | 67 | 7 | IPR001841 | |
| Domain | Znf_FYVE_PHD | 1.84e-04 | 147 | 67 | 5 | IPR011011 | |
| Domain | ZF_BBOX | 1.95e-04 | 80 | 67 | 4 | PS50119 | |
| Domain | Znf_B-box | 2.04e-04 | 81 | 67 | 4 | IPR000315 | |
| Domain | SPRY | 2.69e-04 | 87 | 67 | 4 | SM00449 | |
| Domain | Znf_RING_CS | 2.97e-04 | 163 | 67 | 5 | IPR017907 | |
| Domain | Znf_PHD | 3.20e-04 | 91 | 67 | 4 | IPR001965 | |
| Domain | SPRY | 3.62e-04 | 94 | 67 | 4 | PF00622 | |
| Domain | SPRY_dom | 3.62e-04 | 94 | 67 | 4 | IPR003877 | |
| Domain | B30.2/SPRY | 3.77e-04 | 95 | 67 | 4 | IPR001870 | |
| Domain | B302_SPRY | 3.77e-04 | 95 | 67 | 4 | PS50188 | |
| Domain | ZF_PHD_2 | 3.77e-04 | 95 | 67 | 4 | PS50016 | |
| Domain | ZF_PHD_1 | 3.92e-04 | 96 | 67 | 4 | PS01359 | |
| Domain | PRY | 6.80e-04 | 48 | 67 | 3 | SM00589 | |
| Domain | PRY | 6.80e-04 | 48 | 67 | 3 | IPR006574 | |
| Domain | PHD | 2.48e-03 | 75 | 67 | 3 | PF00628 | |
| Domain | Tubulin_C | 2.80e-03 | 22 | 67 | 2 | SM00865 | |
| Domain | Tubulin_C | 2.80e-03 | 22 | 67 | 2 | PF03953 | |
| Domain | Tubulin/FtsZ_2-layer-sand-dom | 2.80e-03 | 22 | 67 | 2 | IPR018316 | |
| Domain | Znf_PHD-finger | 2.87e-03 | 79 | 67 | 3 | IPR019787 | |
| Domain | Tubulin_C | 3.06e-03 | 23 | 67 | 2 | IPR023123 | |
| Domain | TUBULIN | 3.06e-03 | 23 | 67 | 2 | PS00227 | |
| Domain | Tubulin | 3.06e-03 | 23 | 67 | 2 | IPR000217 | |
| Domain | Tub_FtsZ_C | 3.06e-03 | 23 | 67 | 2 | IPR008280 | |
| Domain | Tubulin | 3.06e-03 | 23 | 67 | 2 | SM00864 | |
| Domain | zf-DHHC | 3.06e-03 | 23 | 67 | 2 | PF01529 | |
| Domain | Tubulin_CS | 3.06e-03 | 23 | 67 | 2 | IPR017975 | |
| Domain | Tubulin_FtsZ_GTPase | 3.33e-03 | 24 | 67 | 2 | IPR003008 | |
| Domain | Tubulin | 3.33e-03 | 24 | 67 | 2 | PF00091 | |
| Domain | Znf_C3HC4_RING-type | 3.39e-03 | 172 | 67 | 4 | IPR018957 | |
| Domain | DHHC | 3.61e-03 | 25 | 67 | 2 | PS50216 | |
| Domain | Znf_DHHC_palmitoyltrfase | 3.61e-03 | 25 | 67 | 2 | IPR001594 | |
| Domain | ZF_RING_1 | 3.90e-03 | 291 | 67 | 5 | PS00518 | |
| Domain | PHD | 4.02e-03 | 89 | 67 | 3 | SM00249 | |
| Pathway | REACTOME_INTERFERON_GAMMA_SIGNALING | 1.60e-05 | 98 | 46 | 5 | M965 | |
| Pubmed | 1.44e-06 | 41 | 70 | 4 | 11331580 | ||
| Pubmed | Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma. | 3.99e-06 | 2 | 70 | 2 | 23867513 | |
| Pubmed | 1.20e-05 | 3 | 70 | 2 | 7565774 | ||
| Pubmed | 1.20e-05 | 3 | 70 | 2 | 9209500 | ||
| Pubmed | The cell proliferation antigen Ki-67 organises heterochromatin. | 1.90e-05 | 410 | 70 | 7 | 26949251 | |
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 33184273 | ||
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 26475525 | ||
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 34384442 | ||
| Pubmed | Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. | 2.39e-05 | 4 | 70 | 2 | 27220849 | |
| Pubmed | The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. | 2.39e-05 | 4 | 70 | 2 | 10748083 | |
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 15828871 | ||
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 25628365 | ||
| Pubmed | 3.98e-05 | 5 | 70 | 2 | 24828152 | ||
| Pubmed | 5.96e-05 | 6 | 70 | 2 | 17217622 | ||
| Pubmed | 5.96e-05 | 6 | 70 | 2 | 16775307 | ||
| Pubmed | 5.96e-05 | 6 | 70 | 2 | 11483504 | ||
| Pubmed | MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. | 7.31e-05 | 40 | 70 | 3 | 30759391 | |
| Pubmed | 8.33e-05 | 7 | 70 | 2 | 10230406 | ||
| Pubmed | 8.33e-05 | 7 | 70 | 2 | 20368362 | ||
| Pubmed | 8.33e-05 | 7 | 70 | 2 | 11861641 | ||
| Pubmed | Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes. | 8.33e-05 | 7 | 70 | 2 | 32145688 | |
| Pubmed | 8.33e-05 | 7 | 70 | 2 | 27008177 | ||
| Pubmed | Unique features of TRIM5alpha among closely related human TRIM family members. | 8.33e-05 | 7 | 70 | 2 | 17156811 | |
| Pubmed | 1.10e-04 | 233 | 70 | 5 | 37704626 | ||
| Pubmed | 1.11e-04 | 8 | 70 | 2 | 11027288 | ||
| Pubmed | 1.11e-04 | 8 | 70 | 2 | 20638939 | ||
| Pubmed | Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. | 1.11e-04 | 8 | 70 | 2 | 27203177 | |
| Pubmed | Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. | 1.19e-04 | 47 | 70 | 3 | 22235033 | |
| Pubmed | 1.42e-04 | 9 | 70 | 2 | 35982156 | ||
| Pubmed | 1.42e-04 | 9 | 70 | 2 | 27591266 | ||
| Pubmed | Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. | 1.42e-04 | 9 | 70 | 2 | 25912140 | |
| Pubmed | 2.17e-04 | 11 | 70 | 2 | 24438103 | ||
| Pubmed | 2.60e-04 | 12 | 70 | 2 | 27910872 | ||
| Pubmed | 2.60e-04 | 12 | 70 | 2 | 34240781 | ||
| Pubmed | 2.60e-04 | 12 | 70 | 2 | 25505247 | ||
| Pubmed | Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. | 3.07e-04 | 13 | 70 | 2 | 19037258 | |
| Pubmed | The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. | 3.07e-04 | 13 | 70 | 2 | 29958295 | |
| Pubmed | 3.58e-04 | 14 | 70 | 2 | 10230407 | ||
| Pubmed | Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. | 3.58e-04 | 14 | 70 | 2 | 25645944 | |
| Pubmed | A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. | 3.58e-04 | 14 | 70 | 2 | 36608670 | |
| Pubmed | 3.58e-04 | 14 | 70 | 2 | 20844136 | ||
| Pubmed | ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. | 5.33e-04 | 17 | 70 | 2 | 16325183 | |
| Pubmed | Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. | 5.98e-04 | 18 | 70 | 2 | 26906416 | |
| Pubmed | 5.98e-04 | 18 | 70 | 2 | 23077300 | ||
| Pubmed | 5.98e-04 | 18 | 70 | 2 | 15601820 | ||
| Pubmed | 6.68e-04 | 19 | 70 | 2 | 15691386 | ||
| Pubmed | 6.68e-04 | 19 | 70 | 2 | 27497298 | ||
| Pubmed | 6.68e-04 | 19 | 70 | 2 | 15698476 | ||
| Pubmed | 6.68e-04 | 19 | 70 | 2 | 22405651 | ||
| Pubmed | 7.41e-04 | 20 | 70 | 2 | 16647879 | ||
| Pubmed | TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. | 7.41e-04 | 20 | 70 | 2 | 25127057 | |
| Pubmed | 7.41e-04 | 20 | 70 | 2 | 20487527 | ||
| Pubmed | TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. | 8.18e-04 | 21 | 70 | 2 | 18248090 | |
| Pubmed | Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I. | 8.18e-04 | 21 | 70 | 2 | 25678554 | |
| Pubmed | Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. | 8.99e-04 | 22 | 70 | 2 | 23826228 | |
| Pubmed | 8.99e-04 | 22 | 70 | 2 | 30587576 | ||
| Pubmed | TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. | 8.99e-04 | 22 | 70 | 2 | 30446499 | |
| Pubmed | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. | 9.83e-04 | 23 | 70 | 2 | 19250909 | |
| Pubmed | 9.83e-04 | 23 | 70 | 2 | 30814516 | ||
| Pubmed | Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. | 9.83e-04 | 23 | 70 | 2 | 22987640 | |
| Pubmed | 1.07e-03 | 24 | 70 | 2 | 27693506 | ||
| Pubmed | Widespread and dynamic translational control of red blood cell development. | 1.16e-03 | 102 | 70 | 3 | 27899360 | |
| Pubmed | Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. | 1.16e-03 | 25 | 70 | 2 | 27340223 | |
| Pubmed | 1.23e-03 | 104 | 70 | 3 | 10470851 | ||
| Pubmed | 1.26e-03 | 105 | 70 | 3 | 22493164 | ||
| Pubmed | 1.52e-03 | 112 | 70 | 3 | 28416769 | ||
| Pubmed | 1.75e-03 | 634 | 70 | 6 | 34591612 | ||
| Pubmed | 1.81e-03 | 119 | 70 | 3 | 23508102 | ||
| Cytoband | Ensembl 112 genes in cytogenetic band chr8q24 | 2.15e-04 | 355 | 70 | 5 | chr8q24 | |
| Cytoband | 8q24.3 | 7.05e-04 | 113 | 70 | 3 | 8q24.3 | |
| GeneFamily | Ring finger proteins | 2.14e-05 | 275 | 56 | 7 | 58 | |
| GeneFamily | PHD finger proteins | 1.73e-04 | 90 | 56 | 4 | 88 | |
| GeneFamily | Ring finger proteins|Tripartite motif containing|ARF GTPase family | 2.13e-04 | 95 | 56 | 4 | 59 | |
| GeneFamily | Zinc fingers DHHC-type|Ankyrin repeat domain containing | 2.49e-03 | 24 | 56 | 2 | 76 | |
| GeneFamily | Tubulins | 2.92e-03 | 26 | 56 | 2 | 778 | |
| Disease | dentate gyrus volume measurement | 1.01e-04 | 39 | 68 | 3 | EFO_0010083 | |
| Disease | melanoma | 2.73e-04 | 248 | 68 | 5 | C0025202 | |
| Disease | hippocampal volume | 6.20e-04 | 297 | 68 | 5 | EFO_0005035 | |
| Disease | cortical surface area measurement, neuroimaging measurement | 1.89e-03 | 227 | 68 | 4 | EFO_0004346, EFO_0010736 | |
| Disease | lysophosphatidylethanolamine 22:6 measurement | 1.90e-03 | 28 | 68 | 2 | EFO_0010371 | |
| Disease | white matter microstructure measurement | 2.07e-03 | 390 | 68 | 5 | EFO_0005674 | |
| Disease | brain connectivity measurement | 2.31e-03 | 400 | 68 | 5 | EFO_0005210 | |
| Disease | brain volume measurement | 2.49e-03 | 595 | 68 | 6 | EFO_0006930 | |
| Disease | nephrolithiasis | 2.64e-03 | 33 | 68 | 2 | EFO_0004253 | |
| Disease | hip bone mineral density | 3.11e-03 | 126 | 68 | 3 | EFO_0007702 | |
| Disease | Autistic Disorder | 3.13e-03 | 261 | 68 | 4 | C0004352 | |
| Disease | cup-to-disc ratio measurement | 3.15e-03 | 430 | 68 | 5 | EFO_0006939 | |
| Disease | bilirubin measurement | 3.55e-03 | 442 | 68 | 5 | EFO_0004570 | |
| Disease | invasive ductal carcinoma (is_marker_for) | 3.86e-03 | 40 | 68 | 2 | DOID:3008 (is_marker_for) | |
| Disease | hippocampal CA4 volume | 4.05e-03 | 41 | 68 | 2 | EFO_0009396 | |
| Disease | autistic disorder (is_implicated_in) | 4.25e-03 | 42 | 68 | 2 | DOID:12849 (is_implicated_in) |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| ACRVWDVFCRDGEEF | 681 | O60347 | |
| GAECQGHWVETRDCF | 501 | O14514 | |
| AECECVGHVETWLLQ | 1691 | Q96DT5 | |
| RWEDTQKHCFVNICD | 1836 | Q96DT5 | |
| AKVQDICFSHDCRWV | 406 | Q9H6U6 | |
| VWCQLNVDHLSDGFC | 1046 | P59510 | |
| VHCDVHFGLVCRNWE | 1566 | Q9HC84 | |
| EECTVAWGVCNHAFH | 66 | P62877 | |
| EDCVVVWGECNHSFH | 71 | Q9UBF6 | |
| CCDDVRTLHQWVNGI | 486 | Q70E73 | |
| LERFQDHCWELRGCS | 141 | Q969Q4 | |
| GAEWRLCEVVEHACR | 131 | P30203 | |
| CDDTWDLEDAHVVCR | 186 | P30203 | |
| VIYETNCHWEGCARE | 476 | P10071 | |
| EGDNRVWCHVCEREN | 36 | Q17RY6 | |
| VWCHVCERENTFECQ | 41 | Q17RY6 | |
| EEVACKEAWEECGYH | 116 | O95848 | |
| DECAWDAHLCREGQR | 4671 | Q8NDA2 | |
| RCDHAFCWGLLEELV | 556 | A6NGR9 | |
| RQWGLCIFDDVIEHC | 881 | O00410 | |
| DREELCQWSAECSIH | 91 | Q9Y5I3 | |
| CNEWFHGDCIRITEK | 46 | Q9P0U4 | |
| HEQSSEDIWAACCVV | 51 | Q96C11 | |
| DRCEEWFHGDCVGIS | 286 | Q9BTC0 | |
| WLHCVCVVGFDLELG | 61 | Q8IWF6 | |
| KCECHFLNGTERVWN | 41 | P13762 | |
| CRYFHEVCDGEGVWR | 66 | O75426 | |
| AQVERYVPEHERCCW | 51 | Q86UT8 | |
| HDGVCQRCKEVLEWR | 41 | Q96MD7 | |
| ENICLHWAAFSGCVD | 906 | Q9H9B1 | |
| VVCKGESHWVDDDCE | 136 | Q13822 | |
| TCRQDALVCFLHWEV | 16 | Q92530 | |
| EKVNCICVDWRHGSR | 116 | P54317 | |
| VQCGWCHDKCVRSEE | 536 | P08581 | |
| HVFCEECLCLWLDRE | 401 | Q96EX2 | |
| RAEFCEACQEGIVHW | 151 | Q5QGT7 | |
| IHCQWCEERIFQKDG | 486 | Q7Z2T5 | |
| FWYVCRTQGVEGDHC | 396 | Q9UPQ4 | |
| HLFCEDEGQLICWRC | 101 | O00635 | |
| WRCRVFLQDHCLAEG | 376 | O15226 | |
| GRCHAFEKEWIECAH | 31 | O43920 | |
| WNTPDCVEIFRHEDC | 176 | P48029 | |
| VSEAECRRAQHSWFC | 311 | Q9UPV7 | |
| CQELEGHWAELERAC | 1601 | Q9NRC6 | |
| HIGWFPAECVEEVQC | 571 | Q9UPX8 | |
| AWVQCDGCDVWFHVA | 306 | Q9Y242 | |
| IAVDEVHCCSQWGHD | 216 | P46063 | |
| CRIWDVFCRDGEEFL | 601 | Q9P2M4 | |
| QHPCCVRLEQAWEEG | 166 | Q99640 | |
| CFWDDCRQHGVTVIL | 366 | Q9Y2P5 | |
| IGCCFWDLALREHAA | 16 | Q9UJT0 | |
| FEADDTCLAHCWVVV | 41 | Q9NWX6 | |
| DRHVCCVFWLNIAAA | 86 | Q69YW2 | |
| RAPDWVDAEECHRCR | 156 | O14964 | |
| LAWAQEHCHEACRGE | 636 | Q6NUQ4 | |
| EHCHEACRGEVTWDC | 641 | Q6NUQ4 | |
| AHICLACFHGFVEIW | 261 | A0A1W2PR48 | |
| CDDAWDLRDAHVVCR | 581 | Q4G0T1 | |
| EDCVCLVWSHEGEIL | 276 | Q9NNW5 | |
| DHKEIDFRCAGESCW | 76 | Q53GA4 | |
| HAREQQFKCVWCGER | 536 | Q9P2F9 | |
| QCVTCRLHRFKEDWG | 71 | Q9NS68 | |
| CNICVEDFDHHCKWV | 131 | Q8WVZ1 | |
| HIRVFLDNNPWVCDC | 286 | Q13641 | |
| DAECVECERGVWDHG | 126 | Q9Y3S2 | |
| CEQEEKWVCVDCVHG | 536 | Q01831 | |
| AHFDLRNCWCVDEAG | 891 | P01266 | |
| DGKVICWVCELSQEH | 111 | Q8IYM9 | |
| CCLEEQRHAEAWTAV | 521 | A8MYJ7 | |
| RRFEECCEAQQHWKQ | 336 | Q5SRH9 | |
| CDNCVERFDHHCPWV | 211 | Q9NUE0 | |
| IGNACWELFCLEHGI | 16 | Q9NY65 | |
| DGKVICWLCERSQEH | 111 | Q9C030 | |
| RCQGESGEWIACHEA | 411 | Q5VTT5 |