Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	NELL1 NELL2 EYS FBN1 SCUBE2 DSC1 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 HRC DGKA LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	9.82e-14	749	64	20	GO:0005509
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBN1 COMP HMCN1 MATN2 LTBP1 FBN3	3.06e-05	188	64	6	GO:0005201
GeneOntologyMolecularFunction	cargo receptor activity	SSC5D LRP2 LRP1B CD163	1.60e-04	85	64	4	GO:0038024
GeneOntologyCellularComponent	extracellular matrix	SSC5D EYS FBN1 FCGBP COMP HMCN1 CD248 SFTPB MATN2 LTBP1 ALB FBN3	6.09e-07	656	64	12	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	SSC5D EYS FBN1 FCGBP COMP HMCN1 CD248 SFTPB MATN2 LTBP1 ALB FBN3	6.29e-07	658	64	12	GO:0030312
GeneOntologyCellularComponent	cell surface	RTP1 ABCG1 KCNA1 CD5L SCUBE2 CD248 LRP2 SCUBE3 ADGRF5 PDGFC ITGB7 ADAM28 NOTCH1 CD163	5.22e-06	1111	64	14	GO:0009986
GeneOntologyCellularComponent	microfibril	FBN1 LTBP1 FBN3	7.66e-06	13	64	3	GO:0001527
GeneOntologyCellularComponent	collagen-containing extracellular matrix	SSC5D EYS FBN1 COMP HMCN1 SFTPB MATN2 LTBP1 ALB	3.22e-05	530	64	9	GO:0062023
GeneOntologyCellularComponent	endoplasmic reticulum lumen	FBN1 AFP HRC LTBP1 ALB PDGFC	5.30e-04	332	64	6	GO:0005788
GeneOntologyCellularComponent	basement membrane	FBN1 HMCN1 MATN2 ALB	5.35e-04	122	64	4	GO:0005604
Domain	EGF_CA	NELL1 NELL2 FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	3.83e-24	86	64	16	PF07645
Domain	EGF_CA	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	2.41e-23	122	64	17	SM00179
Domain	EGF_Ca-bd_CS	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	3.06e-23	97	64	16	IPR018097
Domain	EGF-like_Ca-bd_dom	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	3.23e-23	124	64	17	IPR001881
Domain	EGF_CA	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	4.34e-23	99	64	16	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	NELL1 NELL2 EYS FBN1 SCUBE2 HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	1.39e-22	106	64	16	IPR000152
Domain	EGF	NELL1 NELL2 EYS FBN1 FCGBP SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ADAM28 FBN3 NOTCH1	1.99e-21	235	64	19	SM00181
Domain	ASX_HYDROXYL	NELL1 NELL2 EYS FBN1 SCUBE2 HMCN1 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	3.67e-21	100	64	15	PS00010
Domain	EGF-like_dom	NELL1 NELL2 EYS FBN1 FCGBP SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ADAM28 FBN3 NOTCH1	6.04e-21	249	64	19	IPR000742
Domain	EGF-like_CS	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ITGB7 ADAM28 FBN3 NOTCH1	1.49e-20	261	64	19	IPR013032
Domain	EGF_2	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ITGB7 ADAM28 FBN3 NOTCH1	1.99e-20	265	64	19	PS01186
Domain	EGF_3	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ADAM28 FBN3 NOTCH1	6.99e-20	235	64	18	PS50026
Domain	Growth_fac_rcpt_	NELL1 NELL2 EYS IGF1R FBN1 SCUBE2 COMP HMCN1 CD248 MATN2 LRP2 SCUBE3 LTBP1 LRP1B FBN3 NOTCH1	8.86e-20	156	64	16	IPR009030
Domain	EGF_1	NELL1 NELL2 EYS FBN1 SCUBE2 COMP HMCN1 CD248 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B ITGB7 ADAM28 FBN3 NOTCH1	3.06e-19	255	64	18	PS00022
Domain	cEGF	FBN1 SCUBE2 HMCN1 MATN2 LRP2 SCUBE3 LTBP1 LRP1B FBN3	1.08e-16	26	64	9	IPR026823
Domain	cEGF	FBN1 SCUBE2 HMCN1 MATN2 LRP2 SCUBE3 LTBP1 LRP1B FBN3	1.08e-16	26	64	9	PF12662
Domain	EGF	EYS SCUBE2 HMCN1 CD248 MATN2 NOTCH2NLA LRP2 SCUBE3 LTBP1 NOTCH2NLC LRP1B FBN3 NOTCH1	3.13e-16	126	64	13	PF00008
Domain	SRCR	SSC5D TMPRSS15 CD5L HHIPL1 CD163	7.86e-09	21	64	5	PF00530
Domain	SR	SSC5D TMPRSS15 CD5L HHIPL1 CD163	2.03e-08	25	64	5	SM00202
Domain	-	SSC5D TMPRSS15 CD5L HHIPL1 CD163	2.03e-08	25	64	5	3.10.250.10
Domain	SRCR_1	SSC5D TMPRSS15 CD5L HHIPL1 CD163	2.51e-08	26	64	5	PS00420
Domain	SRCR_2	SSC5D TMPRSS15 CD5L HHIPL1 CD163	2.51e-08	26	64	5	PS50287
Domain	SRCR-like_dom	SSC5D TMPRSS15 CD5L HHIPL1 CD163	2.51e-08	26	64	5	IPR017448
Domain	SRCR	SSC5D TMPRSS15 CD5L HHIPL1 CD163	3.07e-08	27	64	5	IPR001190
Domain	EGF_extracell	NELL1 NELL2 LRP2 LRP1B ITGB7 NOTCH1	5.52e-08	60	64	6	IPR013111
Domain	EGF_2	NELL1 NELL2 LRP2 LRP1B ITGB7 NOTCH1	5.52e-08	60	64	6	PF07974
Domain	TB	FBN1 LTBP1 FBN3	1.33e-06	7	64	3	PF00683
Domain	-	FBN1 LTBP1 FBN3	2.12e-06	8	64	3	3.90.290.10
Domain	TB	FBN1 LTBP1 FBN3	3.18e-06	9	64	3	PS51364
Domain	TB_dom	FBN1 LTBP1 FBN3	3.18e-06	9	64	3	IPR017878
Domain	EGF_3	NELL1 SCUBE2 SCUBE3	8.26e-06	12	64	3	PF12947
Domain	EGF_dom	NELL1 SCUBE2 SCUBE3	8.26e-06	12	64	3	IPR024731
Domain	CUB	TMPRSS15 SCUBE2 SCUBE3 PDGFC	2.37e-05	49	64	4	PF00431
Domain	CUB	TMPRSS15 SCUBE2 SCUBE3 PDGFC	2.57e-05	50	64	4	SM00042
Domain	-	TMPRSS15 SCUBE2 SCUBE3 PDGFC	3.00e-05	52	64	4	2.60.120.290
Domain	CUB	TMPRSS15 SCUBE2 SCUBE3 PDGFC	3.24e-05	53	64	4	PS01180
Domain	Serum_albumin/AFP/Afamin	AFP ALB	3.46e-05	3	64	2	IPR021177
Domain	FBN	FBN1 FBN3	3.46e-05	3	64	2	IPR011398
Domain	VWC_out	NELL1 NELL2 FCGBP	3.58e-05	19	64	3	SM00215
Domain	CUB_dom	TMPRSS15 SCUBE2 SCUBE3 PDGFC	4.32e-05	57	64	4	IPR000859
Domain	ALBUMIN	AFP ALB	6.90e-05	4	64	2	SM00103
Domain	Serum_albumin_N	AFP ALB	6.90e-05	4	64	2	IPR014760
Domain	ALBUMIN_1	AFP ALB	6.90e-05	4	64	2	PS00212
Domain	Serum_albumin_CS	AFP ALB	6.90e-05	4	64	2	IPR020857
Domain	Serum_albumin	AFP ALB	6.90e-05	4	64	2	PF00273
Domain	ALBUMIN_2	AFP ALB	6.90e-05	4	64	2	PS51438
Domain	ConA-like_dom	NELL1 NELL2 EYS TMPRSS15 COMP TRIM47	1.03e-04	219	64	6	IPR013320
Domain	Serum_albumin-like	AFP ALB	1.15e-04	5	64	2	IPR020858
Domain	hEGF	EYS FBN3 NOTCH1	1.18e-04	28	64	3	PF12661
Domain	ALB/AFP/VDB	AFP ALB	1.72e-04	6	64	2	IPR000264
Domain	VWC	NELL1 NELL2 FCGBP	2.97e-04	38	64	3	SM00214
Domain	-	NELL1 NELL2 EYS COMP	3.16e-04	95	64	4	2.60.120.200
Domain	-	LRP2 HHIPL1 LRP1B	3.21e-04	39	64	3	2.120.10.30
Domain	LDLR_class-A_CS	TMPRSS15 LRP2 LRP1B	3.46e-04	40	64	3	IPR023415
Domain	Laminin_G_2	NELL1 NELL2 EYS	3.46e-04	40	64	3	PF02210
Domain	VWF_dom	NELL1 NELL2 FCGBP	4.00e-04	42	64	3	IPR001007
Domain	LamG	NELL1 NELL2 EYS	4.60e-04	44	64	3	SM00282
Domain	Ldl_recept_a	TMPRSS15 LRP2 LRP1B	4.91e-04	45	64	3	PF00057
Domain	-	TMPRSS15 LRP2 LRP1B	5.24e-04	46	64	3	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP2 HHIPL1 LRP1B	5.24e-04	46	64	3	IPR011042
Domain	LDLRA_1	TMPRSS15 LRP2 LRP1B	5.95e-04	48	64	3	PS01209
Domain	Ephrin_rec_like	SCUBE2 SCUBE3	6.23e-04	11	64	2	PF07699
Domain	LDLRA_2	TMPRSS15 LRP2 LRP1B	6.32e-04	49	64	3	PS50068
Domain	LDrepeatLR_classA_rpt	TMPRSS15 LRP2 LRP1B	6.32e-04	49	64	3	IPR002172
Domain	LDLa	TMPRSS15 LRP2 LRP1B	6.32e-04	49	64	3	SM00192
Domain	SEA	TMPRSS15 ADGRF5	1.02e-03	14	64	2	SM00200
Domain	TIL_dom	FCGBP LRP2	1.02e-03	14	64	2	IPR002919
Domain	Ldl_recept_b	LRP2 LRP1B	1.02e-03	14	64	2	PF00058
Domain	LDLRB	LRP2 LRP1B	1.02e-03	14	64	2	PS51120
Domain	Laminin_G	NELL1 NELL2 EYS	1.04e-03	58	64	3	IPR001791
Domain	-	TMPRSS15 ADGRF5	1.18e-03	15	64	2	3.30.70.960
Domain	LY	LRP2 LRP1B	1.18e-03	15	64	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP1B	1.18e-03	15	64	2	IPR000033
Domain	-	HMCN1 MATN2 ITGB7	2.09e-03	74	64	3	3.40.50.410
Domain	SEA	TMPRSS15 ADGRF5	2.55e-03	22	64	2	PF01390
Domain	ZF_BBOX	MYCBP2 TRIM47 TRIM23	2.61e-03	80	64	3	PS50119
Domain	Znf_B-box	MYCBP2 TRIM47 TRIM23	2.71e-03	81	64	3	IPR000315
Domain	TSPN	NELL1 NELL2	2.79e-03	23	64	2	SM00210
Domain	SEA	TMPRSS15 ADGRF5	2.79e-03	23	64	2	PS50024
Domain	SEA_dom	TMPRSS15 ADGRF5	2.79e-03	23	64	2	IPR000082
Domain	VWFA	HMCN1 MATN2 ITGB7	2.80e-03	82	64	3	PS50234
Domain	VWA	HMCN1 MATN2 ITGB7	3.00e-03	84	64	3	SM00327
Domain	Ephrin_rec_like	SCUBE2 SCUBE3	3.30e-03	25	64	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SCUBE2 SCUBE3	3.30e-03	25	64	2	IPR011641
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	SSC5D TMPRSS15 CD5L STON2 LRP2 HHIPL1 LRP1B CD163	5.26e-05	381	50	8	M48063
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	FBN1 AFP HRC LTBP1 ALB	6.41e-05	120	50	5	MM14982
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	FBN1 AFP HRC LTBP1 ALB	7.50e-05	124	50	5	M27285
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	FBN1 LTBP1 FBN3	9.14e-05	25	50	3	M39713
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 LTBP1 FBN3	3.00e-04	37	50	3	M27134
Pathway	REACTOME_HDL_REMODELING	ABCG1 ALB	3.41e-04	8	50	2	MM15568
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	FBN1 LTBP1	3.41e-04	8	50	2	M47850
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 LTBP1 FBN3	5.02e-04	44	50	3	M26969
Pathway	REACTOME_HDL_REMODELING	ABCG1 ALB	5.45e-04	10	50	2	M27849
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	FBN1 COMP SCUBE3 LTBP1 ITGB7 FBN3	6.39e-04	300	50	6	M610
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	NELL1 NELL2 FBN1 MATN2 GRN LTBP1 NOTCH1 TRIM23	5.21e-11	118	64	8	21078624
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	NELL1 NELL2 FBN1 MYCBP2 UBAP2L DBF4B NOTCH2NLA GRN LTBP1 NOTCH1 CD163	5.89e-09	560	64	11	21653829
Pubmed	CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.	AFP CHD1L ALB	1.18e-07	6	64	3	27100146
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	IGF1R LRP2 LRP1B ITGB7 NOTCH1	1.24e-06	101	64	5	23382219
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	NELL1 NELL2 UBAP2L MATN2 NOTCH2NLA LRP2 GRN LTBP1 NOTCH1	1.68e-06	608	64	9	16713569
Pubmed	Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.	AFP ALB NOTCH1	3.27e-06	16	64	3	19185577
Pubmed	Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.	COMP GRN	3.33e-06	2	64	2	17307734
Pubmed	Differential expression of albumin and alpha-fetoprotein genes in fetal tissues of mouse and rat.	AFP ALB	3.33e-06	2	64	2	6199242
Pubmed	Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.	IGF1R NOTCH1	3.33e-06	2	64	2	20154720
Pubmed	The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.	FBN1 LTBP1	3.33e-06	2	64	2	28669633
Pubmed	Linkage of the evolutionarily-related serum albumin and alpha-fetoprotein genes within q11-22 of human chromosome 4.	AFP ALB	3.33e-06	2	64	2	6192711
Pubmed	Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development.	AFP ALB	3.33e-06	2	64	2	7899085
Pubmed	Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2.	NELL1 NELL2	3.33e-06	2	64	2	10548494
Pubmed	Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.	AFP ALB	3.33e-06	2	64	2	8682297
Pubmed	Megalin/gp330 mediates uptake of albumin in renal proximal tubule.	LRP2 ALB	3.33e-06	2	64	2	8898021
Pubmed	The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes.	AFP ALB	3.33e-06	2	64	2	2452956
Pubmed	Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes.	AFP ALB	3.33e-06	2	64	2	6206499
Pubmed	Localization of the L1Md family of repeated sequences in the mouse albumin-alpha-fetoprotein gene complex.	AFP ALB	3.33e-06	2	64	2	6206473
Pubmed	Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions.	NELL1 NELL2	3.33e-06	2	64	2	22157752
Pubmed	Mapping of the hooded, Gc protein, and albumin gene loci in linkage group VI of the laboratory rat.	AFP ALB	3.33e-06	2	64	2	3242495
Pubmed	Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.	IGF1R LRP2	3.33e-06	2	64	2	16306401
Pubmed	Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures.	AFP ALB	3.33e-06	2	64	2	8607965
Pubmed	Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia.	IGF1R NOTCH1	3.33e-06	2	64	2	25786252
Pubmed	Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.	NELL1 NELL2	3.33e-06	2	64	2	25726761
Pubmed	Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage.	COMP NOTCH1	3.33e-06	2	64	2	29981303
Pubmed	Murine alpha-fetoprotein and albumin: two evolutionarily linked proteins encoded on the same mouse chromosome.	AFP ALB	3.33e-06	2	64	2	6170120
Pubmed	The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.	AFP ALB	3.33e-06	2	64	2	19782060
Pubmed	The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage.	NELL1 NELL2	3.33e-06	2	64	2	10231576
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	3.33e-06	2	64	2	15221638
Pubmed	The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.	AFP ALB	3.33e-06	2	64	2	6161929
Pubmed	The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.	AFP ALB	3.33e-06	2	64	2	6161930
Pubmed	High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.	IGF1R NOTCH1	3.33e-06	2	64	2	21807868
Pubmed	alpha-Fetoprotein and albumin genes are in tandem in the mouse genome.	AFP ALB	3.33e-06	2	64	2	6170978
Pubmed	Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.	NELL1 NELL2	3.33e-06	2	64	2	8975702
Pubmed	Scube regulates synovial angiogenesis-related signaling.	SCUBE2 SCUBE3	3.33e-06	2	64	2	24084593
Pubmed	Mechanisms of albumin uptake by proximal tubular cells.	LRP2 ALB	3.33e-06	2	64	2	11158855
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	FBN1 DSC1 AFP LTBP1 PDGFC TRIM23	6.41e-06	247	64	6	39238192
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	SSC5D FBN1 COMP MATN2 GRN LTBP1	6.56e-06	248	64	6	24006456
Pubmed	Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.	SFTPB AFP ALB	6.63e-06	20	64	3	28838957
Pubmed	Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma.	ALB NOTCH1	9.99e-06	3	64	2	27698452
Pubmed	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.	NELL1 NELL2	9.99e-06	3	64	2	32198364
Pubmed	Impaired differentiation of fetal hepatocytes in homozygous jumonji mice.	AFP ALB	9.99e-06	3	64	2	12915229
Pubmed	Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.	SCUBE2 SCUBE3	9.99e-06	3	64	2	12270931
Pubmed	Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease.	LRP2 ALB	9.99e-06	3	64	2	28356267
Pubmed	Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.	AFP ALB	9.99e-06	3	64	2	12297623
Pubmed	Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2.	NELL1 NELL2	9.99e-06	3	64	2	34238763
Pubmed	Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.	IGF1R NOTCH1	9.99e-06	3	64	2	22424712
Pubmed	Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.	LRP2 ALB	9.99e-06	3	64	2	10811843
Pubmed	Linkage between vitamin D-binding protein and alpha-fetoprotein in the mouse.	AFP ALB	9.99e-06	3	64	2	8835525
Pubmed	The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.	SCUBE2 SCUBE3	9.99e-06	3	64	2	31991528
Pubmed	Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.	NELL1 NELL2	9.99e-06	3	64	2	30700556
Pubmed	Alpha-fetoprotein related gene (ARG): a new member of the albumin gene family that is no longer functional in primates.	AFP ALB	9.99e-06	3	64	2	19733224
Pubmed	Molecular Analysis of AFP and HSA Interactions with PTEN Protein.	AFP ALB	9.99e-06	3	64	2	26078940
Pubmed	Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice.	AFP ALB	9.99e-06	3	64	2	12105862
Pubmed	Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.	NELL1 NELL2	9.99e-06	3	64	2	35940226
Pubmed	LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.	FBN1 LTBP1	9.99e-06	3	64	2	17293099
Pubmed	Elevation of LncRNA ENST00000453774.1 Prevents Renal Fibrosis by Upregulating FBN1, IGF1R, and KLF7.	IGF1R FBN1	9.99e-06	3	64	2	34614499
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	FBN1 HMCN1 SFTPB MATN2 LTBP1	1.46e-05	167	64	5	22159717
Pubmed	Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene.	AFP ALB	2.00e-05	4	64	2	16467207
Pubmed	Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.	NOTCH2NLA NOTCH2NLC	2.00e-05	4	64	2	29561261
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN3	2.00e-05	4	64	2	25034023
Pubmed	A lethal deletion on mouse chromosome 7 affects regulation of liver-cell-specific functions: posttranscriptional control of serum protein and transcriptional control of aldolase B synthesis.	AFP ALB	2.00e-05	4	64	2	3857594
Pubmed	Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.	NOTCH2NLA NOTCH2NLC	2.00e-05	4	64	2	32330268
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 LTBP1	2.00e-05	4	64	2	12429738
Pubmed	A highly conserved mouse gene with a propensity to form pseudogenes in mammals.	AFP ALB	2.00e-05	4	64	2	3405219
Pubmed	p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs.	ALB NOTCH1	2.00e-05	4	64	2	32555153
Pubmed	Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.	AFP ALB	2.00e-05	4	64	2	19301403
Pubmed	Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.	AFP ALB	2.00e-05	4	64	2	19015022
Pubmed	Characterization of a mouse Scube3 reporter line.	SCUBE2 SCUBE3	2.00e-05	4	64	2	20957652
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	FBN1 COMP GRN	2.57e-05	31	64	3	31550482
Pubmed	Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.	AFP ALB	3.32e-05	5	64	2	18669658
Pubmed	NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.	NELL2 ADAM28	3.32e-05	5	64	2	32499443
Pubmed	Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.	NOTCH2NLA NOTCH2NLC	3.32e-05	5	64	2	29856954
Pubmed	Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.	NOTCH2NLA NOTCH2NLC	3.32e-05	5	64	2	29856955
Pubmed	Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.	SCUBE2 SCUBE3	3.32e-05	5	64	2	23383134
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 LTBP1	3.32e-05	5	64	2	34411563
Pubmed	Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.	UBAP2L DBF4B RAD54B DGKA ALB	3.55e-05	201	64	5	25192599
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	IFT140 ZNF366 LRP2 LTBP1	3.58e-05	100	64	4	25807483
Pubmed	Proteomics characterization of extracellular space components in the human aorta.	FBN1 COMP MATN2 LTBP1	3.72e-05	101	64	4	20551380
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	NELL1 COMP MATN2 DGKA NOTCH1	4.37e-05	210	64	5	16537572
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	DSC1 DBF4B ALB DDX39B	4.67e-05	107	64	4	32989256
Pubmed	Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.	ITGB7 NOTCH1	4.98e-05	6	64	2	24829201
Pubmed	Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.	FBN1 LTBP1	4.98e-05	6	64	2	19349279
Pubmed	Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.	NELL1 NELL2	4.98e-05	6	64	2	26586761
Pubmed	BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein.	FBN1 LTBP1	4.98e-05	6	64	2	17015622
Pubmed	Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development.	AFP ALB	4.98e-05	6	64	2	15519652
Pubmed	Over-expression of PDGF-C using a lung specific promoter results in abnormal lung development.	SFTPB PDGFC	4.98e-05	6	64	2	16830225
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	UBAP2L SYNE2 COPG2 LRP1B NOTCH1 ZC3HAV1	6.68e-05	375	64	6	32788342
Pubmed	Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.	FBN1 NOTCH1	6.96e-05	7	64	2	29093270
Pubmed	Immunohistochemical analysis of development of desmin-positive hepatic stellate cells in mouse liver.	AFP ALB	6.96e-05	7	64	2	11197537
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE2 SCUBE3	6.96e-05	7	64	2	25639508
Pubmed	Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma.	AFP ALB	6.96e-05	7	64	2	34880251
Pubmed	Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D.	SFTPB ADGRF5	6.96e-05	7	64	2	23922714
Pubmed	The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.	NELL2 IGF1R LTBP1	7.46e-05	44	64	3	27224923
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	DSC1 UBAP2L ALB NMT1 ZC3HAV1	9.05e-05	245	64	5	35652658
Pubmed	Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size.	SFTPB ADGRF5	9.27e-05	8	64	2	23590306
Pubmed	The role of notch signaling in the development of intrahepatic bile ducts.	AFP ALB	1.19e-04	9	64	2	15578515
Pubmed	Neighbor of Punc E 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development.	AFP ALB	1.19e-04	9	64	2	22497843
Pubmed	KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.	AFP ALB	1.19e-04	9	64	2	23746980
Pubmed	Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.	AFP ALB	1.19e-04	9	64	2	21596989
Interaction	NTN5 interactions	FBN1 LRP2 LTBP1 LRP1B NOTCH1	1.03e-08	24	63	5	int:NTN5
Interaction	ZNF408 interactions	NELL2 FBN1 NOTCH2NLA LRP2 GRN LTBP1 LRP1B TRIM23	1.64e-08	145	63	8	int:ZNF408
Interaction	ZFP41 interactions	NELL2 FBN1 LRP2 GRN LTBP1 LRP1B	2.34e-08	57	63	6	int:ZFP41
Interaction	ATXN7 interactions	NELL1 NELL2 FBN1 MATN2 GRN TRIM23	1.15e-06	109	63	6	int:ATXN7
Interaction	MATN2 interactions	NELL1 NELL2 COMP MATN2 SCUBE3 ALB	1.42e-06	113	63	6	int:MATN2
Interaction	HOXA1 interactions	NELL1 NELL2 FBN1 DBF4B NOTCH2NLA GRN LTBP1 NOTCH1 CD163	1.55e-06	356	63	9	int:HOXA1
Interaction	CACNA1A interactions	NELL1 NELL2 MATN2 GRN LTBP1 NOTCH1	2.34e-06	123	63	6	int:CACNA1A
Interaction	IGFL3 interactions	MYCBP2 LRP2 GRN LRP1B NOTCH1	3.70e-06	75	63	5	int:IGFL3
Interaction	EGFL7 interactions	NELL1 NELL2 IGF1R GRN NOTCH1	4.22e-06	77	63	5	int:EGFL7
Interaction	DKK2 interactions	LRP2 LRP1B NOTCH1 TRIM23	1.65e-05	49	63	4	int:DKK2
Interaction	NELL2 interactions	NELL1 NELL2 MATN2 LTBP1	2.26e-05	53	63	4	int:NELL2
Interaction	IGFBP3 interactions	IGF1R RAD54B LRP2 LTBP1	3.96e-05	61	63	4	int:IGFBP3
Interaction	FBXO2 interactions	NELL2 IGF1R FBN1 SYNE2 LRP2 GRN LRP1B NOTCH1	4.06e-05	411	63	8	int:FBXO2
Interaction	NUFIP2 interactions	NELL1 NELL2 COMP UBAP2L MATN2 NOTCH2NLA GRN ZC3HAV1	4.50e-05	417	63	8	int:NUFIP2
Interaction	SCUBE1 interactions	SCUBE2 SCUBE3	9.56e-05	5	63	2	int:SCUBE1
Interaction	NICOL1 interactions	NELL1 NELL2	9.56e-05	5	63	2	int:NICOL1
Interaction	MBD1 interactions	NELL1 NELL2 GRN NOTCH1	9.89e-05	77	63	4	int:MBD1
Interaction	ZNF517 interactions	LRP2 GRN LRP1B	1.00e-04	29	63	3	int:ZNF517
Interaction	APOB interactions	NELL1 MATN2 LRP2 ALB TRIM23	1.28e-04	156	63	5	int:APOB
Interaction	RIBC2 interactions	RAD54B LRP2 TRIM23	1.35e-04	32	63	3	int:RIBC2
Interaction	TIMP2 interactions	FBN1 DSC1 AFP LTBP1 PDGFC TRIM23	2.25e-04	277	63	6	int:TIMP2
Interaction	SCUBE3 interactions	MATN2 SCUBE3	2.66e-04	8	63	2	int:SCUBE3
Interaction	LINC00526 interactions	NOTCH2NLA TRIM23	2.66e-04	8	63	2	int:LINC00526
Interaction	ATN1 interactions	NELL1 NELL2 LRP2 GRN LTBP1	2.96e-04	187	63	5	int:ATN1
Interaction	SERPING1 interactions	MATN2 GRN ALB	3.06e-04	42	63	3	int:SERPING1
Interaction	NELL1 interactions	NELL1 NELL2 MATN2	3.06e-04	42	63	3	int:NELL1
Cytoband	5q12.3	TRAPPC13 TRIM23	2.89e-04	18	64	2	5q12.3
GeneFamily	Low density lipoprotein receptors	LRP2 LRP1B	2.64e-04	13	34	2	634
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC5D CD163	1.17e-03	27	34	2	1253
GeneFamily	Ankyrin repeat domain containing	ESPN ASB1 NOTCH1	1.04e-02	242	34	3	403
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM47 TRIM23	1.37e-02	95	34	2	59
Coexpression	NABA_ECM_GLYCOPROTEINS	NELL1 NELL2 EYS FBN1 COMP HMCN1 MATN2 LTBP1 FBN3	1.02e-09	196	63	9	M3008
Coexpression	NABA_MATRISOME	NELL1 NELL2 EYS TMPRSS15 FBN1 SCUBE2 COMP HMCN1 SFTPB MATN2 SCUBE3 LTBP1 PDGFC ADAM28 FBN3	1.47e-08	1026	63	15	M5889
Coexpression	NABA_CORE_MATRISOME	NELL1 NELL2 EYS FBN1 COMP HMCN1 MATN2 LTBP1 FBN3	1.95e-08	275	63	9	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	NELL1 NELL2 FBN1 COMP HMCN1 MATN2 LTBP1	3.83e-07	191	63	7	MM17059
Coexpression	NABA_MATRISOME	NELL1 NELL2 TMPRSS15 FBN1 SCUBE2 COMP HMCN1 SFTPB MATN2 SCUBE3 LTBP1 PDGFC ADAM28	6.54e-07	1008	63	13	MM17056
Coexpression	NABA_CORE_MATRISOME	NELL1 NELL2 FBN1 COMP HMCN1 MATN2 LTBP1	3.85e-06	270	63	7	MM17057
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL	ESPN TRAPPC13 SSC5D SCUBE2 MATN2 WBP1L RAD54B NOTCH2NLA PDGFC TRIM47 NMT1	3.82e-05	1054	63	11	M45798
Coexpression	GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_DN	FBN1 DSC1 AFP SCUBE3 HRC	1.15e-04	198	63	5	M7261
Coexpression	GSE17721_POLYIC_VS_CPG_8H_BMDC_UP	ESPN ABCG1 WBP1L DGKA ITGB7	1.18e-04	199	63	5	M3945
Coexpression	GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_DN	AFP SYNE2 SCUBE3 ITGB7 CD163	1.18e-04	199	63	5	M7498
Coexpression	GSE9650_NAIVE_VS_EFF_CD8_TCELL_UP	ABCG1 IGF1R MYCBP2 DGKA NOTCH1	1.21e-04	200	63	5	M5819
Coexpression	GSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_IL6_TREATED_DN	DSC1 GRN PDGFC ITGB7 ADAM28	1.21e-04	200	63	5	M7453
Coexpression	KAECH_NAIVE_VS_DAY8_EFF_CD8_TCELL_UP	ABCG1 IGF1R MYCBP2 DGKA NOTCH1	1.21e-04	200	63	5	M3012
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_500	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	4.69e-06	146	63	6	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_500
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#2	NELL1 SSC5D NELL2 FBN1 HMCN1 CD248 AFP MATN2 LRP2 SCUBE3 ALB FBN3	1.96e-05	951	63	12	Arv_EB-LF_2500_K2
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	3.41e-05	207	63	6	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	MATN2 STON2 LRP2 DGKA GRN LTBP1 PDGFC	3.70e-05	311	63	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#3	SSC5D STON2 SCUBE3 DGKA GRN LTBP1 PDGFC	3.70e-05	311	63	7	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K3
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3	NELL1 SSC5D TMPRSS15 FBN1 HMCN1 CD248 AFP LRP2 SCUBE3 ALB PDGFC LRP1B	7.68e-05	1094	63	12	ratio_EB_vs_SC_2500_K3
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_500	NELL1 FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	1.48e-04	388	63	7	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_100	AFP ALB	2.40e-04	8	63	2	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100_k2
CoexpressionAtlas	ECTO blastocyst_vs_ECTO cord blood-Confounder_removed-fold2.0_adjp0.05	KCNA1 SCUBE2 LTBP1 PDGFC FBN3	2.45e-04	189	63	5	PCBC_ratio_ECTO blastocyst_vs_ECTO cord blood_cfr-2X-p05
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#2_top-relative-expression-ranked_200	HMCN1 CD248 MATN2	2.63e-04	42	63	3	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k2_200
CoexpressionAtlas	dev gonad_e11.5_M_GonMes_Sma_k-means-cluster#3_top-relative-expression-ranked_1000	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	3.17e-04	311	63	6	gudmap_dev gonad_e11.5_M_GonMes_Sma_k3_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#1_top-relative-expression-ranked_500	NELL1 KCNA1 SCUBE3 LTBP1	3.21e-04	110	63	4	gudmap_developingKidney_e15.5_Podocyte cells_500_k1
CoexpressionAtlas	kidney_P3_CapMes_Crym_top-relative-expression-ranked_1000	NELL1 FBN1 HMCN1 RAD54B SCUBE3 LTBP1 WDR54 PDGFC NOTCH1	3.46e-04	749	63	9	gudmap_kidney_P3_CapMes_Crym_1000
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#3	NELL1 AFP SCUBE3 ALB LRP1B	3.48e-04	204	63	5	ratio_EB_vs_SC_500_K3
CoexpressionAtlas	kidney_P1_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_100	HMCN1 PDGFC	3.84e-04	10	63	2	gudmap_kidney_P1_CapMes_Crym_k2_100
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_k-means-cluster#4_top-relative-expression-ranked_1000	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	4.14e-04	327	63	6	gudmap_dev gonad_e11.5_F_GonMes_Sma_k4_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#3_top-relative-expression-ranked_200	AFP ALB	4.68e-04	11	63	2	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200_k3
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	4.85e-04	337	63	6	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
CoexpressionAtlas	kidney_P0_CapMes_Crym_top-relative-expression-ranked_200	NELL1 HMCN1 HRC PDGFC	5.06e-04	124	63	4	gudmap_kidney_P0_CapMes_Crym_200
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#2_top-relative-expression-ranked_1000	GGNBP2 HMCN1 UBAP2L AFP	5.37e-04	126	63	4	gudmap_developingGonad_e14.5_ ovary_1000_k2
CoexpressionAtlas	kidney_P0_CapMes_Crym_k-means-cluster#1_top-relative-expression-ranked_100	HMCN1 PDGFC	5.61e-04	12	63	2	gudmap_kidney_P0_CapMes_Crym_k1_100
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-Ectoderm_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500	NELL1 NELL2 KCNA1 SCUBE2 LRP2 SCUBE3 FBN3	5.84e-04	487	63	7	PCBC_ECTO_blastocyst_500
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000	NELL1 NELL2 AFP MATN2 LRP2 SCUBE3 HRC ALB LRP1B FBN3	6.06e-04	986	63	10	PCBC_EB_fibroblast_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500	TRAPPC13 ABCG1 STON2 LRP2 SCUBE3 COPG2 PDGFC	6.12e-04	491	63	7	Facebase_RNAseq_e9.5_Olfactory Placode_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_200	MATN2 LTBP1 PDGFC	6.17e-04	56	63	3	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k4_200
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	FBN1 HMCN1 CD248 MATN2 LTBP1 PDGFC	6.28e-04	354	63	6	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_1000
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_EmbryoidBody_top-relative-expression-ranked_1000	NELL1 NELL2 AFP MATN2 LRP2 SCUBE3 HRC ALB LRP1B FBN3	6.45e-04	994	63	10	PCBC_EB_1000
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500	NELL1 CD248 AFP SCUBE3 ALB PDGFC LRP1B	6.66e-04	498	63	7	PCBC_ratio_EB_vs_SC_500
CoexpressionAtlas	kidney_P3_CapMes_Crym_k-means-cluster#1_top-relative-expression-ranked_1000	NELL1 HMCN1 LTBP1 WDR54 PDGFC	6.76e-04	236	63	5	gudmap_kidney_P3_CapMes_Crym_k1_1000
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC13 NELL2 IGF1R DSC1 CD248 DGKA ZC3HAV1	1.05e-08	189	64	7	e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC13 NELL2 IGF1R CD248 SYNE2 DGKA TRIM23	1.13e-08	191	64	7	696921a4f160b6b55698652488ed781e855e5e51
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SSC5D FBN1 KCNA1 COMP HMCN1 MATN2 LTBP1	1.44e-08	198	64	7	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-4\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SSC5D FBN1 COMP HMCN1 CD248 LTBP1 HHIPL1	1.55e-08	200	64	7	54b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC13 NELL2 IGF1R SYNE2 DGKA ZC3HAV1	2.57e-07	183	64	6	f2ef110bf29b1a8276ef216238363e542db262c1
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	2.65e-07	184	64	6	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	3.31e-07	191	64	6	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NELL2 IGF1R FCGBP DSC1 CD248 DGKA	3.51e-07	193	64	6	95f5611dd9583f339b7c9f52bb478af204fb89ad
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SSC5D FBN1 COMP CD248 MATN2 LTBP1	3.51e-07	193	64	6	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SSC5D FBN1 COMP CD248 MATN2 LTBP1	3.51e-07	193	64	6	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP CD248 MATN2 LTBP1	3.73e-07	195	64	6	1236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SSC5D FBN1 COMP CD248 MATN2 LTBP1	3.96e-07	197	64	6	4cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	SSC5D NELL2 COMP HMCN1 LTBP1 PDGFC	4.08e-07	198	64	6	196257c4420ac801ed9fbb444f11718adb7560ae
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SSC5D FBN1 COMP HMCN1 MATN2 LTBP1	4.20e-07	199	64	6	e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	4dbe21cb63569f28c7017cda065ea5ee00d7254e
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	bde938e5a18844fb8cc1d1be5a086809f7e2b97d
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	8256511b099c3eab8e33194f90c9ff354e7cfe8e
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	54806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCell	Biopsy_IPF-Mesenchymal-Myofibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	SSC5D FBN1 COMP HMCN1 CD248 LTBP1	4.33e-07	200	64	6	c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCell	COVID-19-kidney-Technical/muscle\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NELL1 HORMAD2 EYS TMPRSS15 LRP1B	1.72e-06	139	64	5	13247bcb21c57c808657e0f543d6f134eeea7cc1
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HORMAD2 ABCG1 GRN CD163 TRIM23	4.24e-06	167	64	5	881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP HMCN1 LTBP1	5.32e-06	175	64	5	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NELL2 IGF1R DSC1 CD248 SYNE2	5.78e-06	178	64	5	73936c2e7e8855b4ab65cad425686513dba331a3
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FCGBP CD5L GRN TRIM47 CD163	5.78e-06	178	64	5	e44b0aa82890ae84fc4d1343f1c65ae2fda69a11
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP HMCN1 LTBP1	6.27e-06	181	64	5	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	NELL2 SYNE2 DGKA DDX39B ZC3HAV1	6.27e-06	181	64	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D COMP CD248 MATN2 LTBP1	6.62e-06	183	64	5	2beb5414958d38a5341870d55229f3b1707e76bf
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ESPN SCUBE2 SYNE2 ADGRF5 TRIM47	6.79e-06	184	64	5	a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NELL1 NELL2 KCNA1 PDGFC LRP1B	6.79e-06	184	64	5	9a185e6ea86bbfbb48bfe88650a8c05ceba78d7f
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	NELL2 FCGBP DSC1 CD248 DGKA	6.79e-06	184	64	5	0299cd30a3ea8e861a9d529043c204048ae21d29
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ESPN SCUBE2 SYNE2 ADGRF5 TRIM47	6.79e-06	184	64	5	39c230d32e4259bc784e0edfd9e2884c96898564
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ESPN SCUBE2 SYNE2 ADGRF5 TRIM47	6.79e-06	184	64	5	2a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC13 NELL2 IGF1R SYNE2 DGKA	6.79e-06	184	64	5	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	6.97e-06	185	64	5	863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 HMCN1 CD248 LTBP1	6.97e-06	185	64	5	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	6.97e-06	185	64	5	27dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	SSC5D FBN1 CD248 MATN2 LTBP1	6.97e-06	185	64	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 KCNA1 HMCN1 MATN2	6.97e-06	185	64	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	6.97e-06	185	64	5	1c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 KCNA1 HMCN1 MATN2	6.97e-06	185	64	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	6.97e-06	185	64	5	ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	SCUBE2 SFTPB SCUBE3 ADGRF5 FBN3	7.35e-06	187	64	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCG1 COMP HMCN1 ADGRF5 NOTCH1	7.54e-06	188	64	5	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCG1 COMP HMCN1 ADGRF5 NOTCH1	7.54e-06	188	64	5	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NELL2 IGF1R SYNE2 DGKA ZC3HAV1	7.74e-06	189	64	5	9ab77c6fcb573854da5922412f53d2168bda6b58
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NELL2 IGF1R SYNE2 DGKA ZC3HAV1	7.74e-06	189	64	5	5a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCell	droplet-Kidney-nan-3m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 KCNA1 CD248 MATN2	7.94e-06	190	64	5	2abeb013bb83c578e67dcb985ba44ca63134950b
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	ABCG1 CD5L GRN PDGFC CD163	8.14e-06	191	64	5	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC13 NELL2 IGF1R SYNE2 DGKA	8.14e-06	191	64	5	d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	FBN1 COMP HMCN1 CD248 LTBP1	8.14e-06	191	64	5	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	FBN1 COMP HMCN1 CD248 LTBP1	8.14e-06	191	64	5	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 KCNA1 CD248 MATN2	8.14e-06	191	64	5	d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NELL2 IGF1R DSC1 CD248 DGKA	8.35e-06	192	64	5	ef8970e5389bd55c1624cd6dd01a7ca7abaa8950
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	8.35e-06	192	64	5	ad2e0f35d50fe4e6977eba8a7a2bd990f6946305
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	NELL2 SYNE2 DGKA DDX39B ZC3HAV1	8.35e-06	192	64	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	8.35e-06	192	64	5	284955fec5103194d416320f41fa4d87c7efc4fb
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF1R HMCN1 ZNF366 ADGRF5 TRIM47	8.35e-06	192	64	5	9ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	8.35e-06	192	64	5	0d3b2b9cd586a4adbc3755563dd50b140227c287
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SSC5D FBN1 CD248 MATN2 LTBP1	8.35e-06	192	64	5	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF1R HMCN1 ZNF366 ADGRF5 TRIM47	8.35e-06	192	64	5	a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP MATN2 LTBP1	8.35e-06	192	64	5	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	8.35e-06	192	64	5	67f50e5b1d449923002dc5b5d0c4d32c523034d3
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF1R HMCN1 ZNF366 ADGRF5 TRIM47	8.35e-06	192	64	5	66defad13bd8e79319741e43ddb056841710b1d7
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 CD248 MATN2 LTBP1	8.56e-06	193	64	5	0a665531d581d4e3941e29d3f95569da8f166447
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	NELL2 FCGBP DSC1 CD248 DGKA	8.56e-06	193	64	5	627d345baf1940218c61907305705298e473dbab
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	8.56e-06	193	64	5	d371403b51281a6e37652fa8dc1b2dd81d2ab371
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NELL2 FCGBP DSC1 CD248 DGKA	8.56e-06	193	64	5	6436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCell	distal-Hematologic-IGSF21+_Dendritic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FCGBP STON2 PDGFC ADAM28 CD163	8.56e-06	193	64	5	48ce11778252ae2ef902b30816061b59a3c81695
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	8.56e-06	193	64	5	3cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NELL2 FCGBP DSC1 CD248 DGKA	8.56e-06	193	64	5	d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D FBN1 CD248 MATN2 LTBP1	8.56e-06	193	64	5	24ce1f37cca655415410d2403a52d1ebb3332280
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COMP HMCN1 WBP1L TRIM47 NOTCH1	8.78e-06	194	64	5	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	COVID-19_Mild-CD8+_T_naive\|COVID-19_Mild / Disease condition and Cell class	NELL2 FCGBP DSC1 CD248 DGKA	8.78e-06	194	64	5	4e42df4f6db456ab914ddfb2a938dfc462f8b6bf
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COMP HMCN1 WBP1L TRIM47 NOTCH1	9.00e-06	195	64	5	df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 SCUBE3 HRC LTBP1 TRIM47	9.00e-06	195	64	5	43d372373367b71243c6ea958aedccde4478618f
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP HMCN1 LTBP1	9.00e-06	195	64	5	51db90e7611f7d69980878c046505ff34212079b
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ESPN NELL1 SCUBE2 SFTPB ADGRF5	9.23e-06	196	64	5	a4cc02ea41479d24044bd2ca6441f85d683c0ca9
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	FBN1 COMP HMCN1 CD248 LTBP1	9.23e-06	196	64	5	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ESPN NELL1 SCUBE2 SFTPB ADGRF5	9.23e-06	196	64	5	50aaca81b593ff71790bb75403b2e4c3ab03a6d2
ToppCell	IPF-Stromal-Myofibroblast\|IPF / Disease state, Lineage and Cell class	FBN1 COMP HMCN1 CD248 LTBP1	9.23e-06	196	64	5	2d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SFTPB LRP2 COX17 ADGRF5 CD163	9.23e-06	196	64	5	006d783a530aa6e1e6545dcc2e6b00bb300fe070
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	FBN1 COMP HMCN1 CD248 LTBP1	9.23e-06	196	64	5	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	(3)_Macrophage_MARCOneg\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	NELL1 FCGBP GRN PDGFC CD163	9.46e-06	197	64	5	b0ee2ce1179b60b4542559acb300a34295277dbc
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ABCG1 FCGBP CD5L GRN CD163	9.46e-06	197	64	5	72775eb6c24cfb956436642ac9cd6e4d5c01ea5f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP CD248 LTBP1	9.46e-06	197	64	5	71786e9432e2d649f5d86f639abb25e7102deb67
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-MYL4+_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SSC5D COMP SCUBE3 LTBP1 PDGFC	9.46e-06	197	64	5	4797f414330316e2ac2cf7cd2570d991877d7a38
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 COMP HMCN1 MATN2 LTBP1	9.46e-06	197	64	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SSC5D COMP HMCN1 LTBP1 PDGFC	9.69e-06	198	64	5	c55608633f66e3d434c5d81324efb07c5120d2c2
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 COMP HMCN1 CD248 LTBP1	9.69e-06	198	64	5	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCUBE2 COMP MATN2 SCUBE3 LRP1B	9.69e-06	198	64	5	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	367C\|World / Donor, Lineage, Cell class and subclass (all cells)	ABCG1 COMP HMCN1 GRN CD163	9.69e-06	198	64	5	ab3a178f392204e2d90eb5a3b5de7849986b1eaf
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SSC5D COMP HMCN1 LTBP1 PDGFC	9.69e-06	198	64	5	3e5459038fc6ed95f529eb4d1dc5113e16c19012
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCUBE2 COMP MATN2 SCUBE3 LRP1B	9.69e-06	198	64	5	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NELL1 FBN1 CD248 MATN2 ADAM28	9.93e-06	199	64	5	30ab0750d51f168b18c434c974d24a4e70f29cc7
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP CD248 LTBP1	9.93e-06	199	64	5	9672230aa0bc6a7289050c955f5154ca183a5159
ToppCell	medial-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SSC5D FBN1 COMP HMCN1 LTBP1	9.93e-06	199	64	5	95aae608fa35a9c82b12c6f18937ce636750ca44
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SSC5D FBN1 COMP CD248 LTBP1	9.93e-06	199	64	5	e18abe678da293bd01fae55e2f9ab6fdd643d02d
Computational	Metal / Ca ion binding.	NELL1 FBN1 COMP DGKA LTBP1	1.98e-04	133	44	5	MODULE_324
Computational	Genes in the cancer module 119.	TRAPPC13 MYCBP2 SYNE2 DGKA ITGB7	2.78e-04	143	44	5	MODULE_119
Computational	Genes in the cancer module 544.	COMP AFP RAD54B FBN3	4.43e-04	88	44	4	MODULE_544
Computational	Genes in the cancer module 481.	COMP AFP RAD54B FBN3	4.63e-04	89	44	4	MODULE_481
Disease	Zollinger-Ellison syndrome (is_marker_for)	IGF1R ALB	4.49e-06	2	63	2	DOID:0050782 (is_marker_for)
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN3	1.34e-05	3	63	2	DOID:65 (implicated_via_orthology)
Disease	Hantavirus hemorrhagic fever with renal syndrome (is_marker_for)	ALB CD163	1.25e-04	8	63	2	DOID:11266 (is_marker_for)
Disease	Liver Cirrhosis, Experimental	ABCG1 FBN1 CD5L AFP GRN LTBP1 ALB CD163	2.34e-04	774	63	8	C0023893
Disease	dementia (is_implicated_in)	IGF1R GRN	2.92e-04	12	63	2	DOID:1307 (is_implicated_in)
Disease	migraine disorder, endometriosis	NELL1 EYS LRP1B	5.19e-04	73	63	3	EFO_0001065, MONDO_0005277
Disease	lung adenocarcinoma	SSC5D SFTPB HHIPL1 PDGFC	5.31e-04	174	63	4	EFO_0000571
Disease	Disproportionate short stature	IFT140 FBN1 COMP	6.06e-04	77	63	3	C0878659
Disease	glomerulonephritis (biomarker_via_orthology)	FBN1 LTBP1	8.32e-04	20	63	2	DOID:2921 (biomarker_via_orthology)
Disease	waist-hip ratio	NELL1 SSC5D IGF1R SCUBE2 MYCBP2 SYNE2 ADGRF5 ASB1 PDGFC	1.13e-03	1226	63	9	EFO_0004343
Disease	FEV/FEC ratio	NELL2 FBN1 FCGBP HMCN1 SYNE2 SCUBE3 LTBP1 HHIPL1 TTC1	1.14e-03	1228	63	9	EFO_0004713
Disease	unipolar depression, neuroticism measurement	EYS ZNF366	1.20e-03	24	63	2	EFO_0003761, EFO_0007660
Disease	eye colour measurement	KCNA1 CD5L MYCBP2 LRP2	1.23e-03	218	63	4	EFO_0009764
Disease	Endogenous Hyperinsulinism	FBN1 CD163	1.41e-03	26	63	2	C1257963
Disease	Exogenous Hyperinsulinism	FBN1 CD163	1.41e-03	26	63	2	C1257964
Disease	Compensatory Hyperinsulinemia	FBN1 CD163	1.41e-03	26	63	2	C1257965
Disease	pneumonia (is_marker_for)	ALB CD163	1.64e-03	28	63	2	DOID:552 (is_marker_for)
Disease	glucose metabolism disease (implicated_via_orthology)	IGF1R DGKA	1.64e-03	28	63	2	DOID:4194 (implicated_via_orthology)
Disease	Hyperinsulinism	FBN1 CD163	1.64e-03	28	63	2	C0020459
Disease	Hyperglycemia, Postprandial	FBN1 CD163	1.88e-03	30	63	2	C1855520
Disease	Hyperglycemia	FBN1 CD163	1.88e-03	30	63	2	C0020456

Protein segments in the cluster

Peptide	Gene	Start	Entry
HTECCHGDLLECADD	ALB	266	P02768
LDREDLHCDIDETCH	ABCG1	616	P45844
HAVCDHELQCQCEEG	ADAM28	636	Q9UKQ2
VDCGFEHPSEVQHEC	DDX39B	61	Q13838
GCEHECVEEVDGHVS	CD248	241	Q9HCU0
EQFCDHPLEHCEDTR	ASB1	26	Q9Y576
ECHEHADCVLERDGS	COMP	236	P49747
VKDVECGEGHFCHDN	GRN	516	P28799
GFHDCTHQEDVAVIC	CD5L	331	O43866
VDECEVGGHNCDSHA	FBN3	1281	Q75N90
GFECHDLDECVSQEH	FBN3	1316	Q75N90
RDVDECADGQQDCHA	FBN3	2206	Q75N90
GEEHCGHLIEAHKEC	COX17	41	Q14061
HESSDCVTHDLLDCE	RAD54B	816	Q9Y620
ETDVNECDIPGHCQH	NOTCH2NLA	141	Q7Z3S9
DVALEHHEECDCVCR	PDGFC	326	Q9NRA1
HGVNCSEEIDECLSH	NOTCH1	1176	P46531
RQADHDDHECCERVV	KCNA1	26	Q09470
LCDGIHDCVDGSDEE	LRP1B	3651	Q9NZR2
QAIDHGCEHICVNSD	MATN2	571	O00339
EQDIDDCILNACEHN	EYS	731	Q5T1H1
EDCGLELNDEDGHRC	LIMD1	631	Q9UGP4
GHEHCSDCENEEDNS	NMT1	26	P30419
TEHDECITNQHNCDE	NELL2	481	Q99435
ACTEGICNHDEHGDD	GGNBP2	486	Q9H3C7
GTHNCEHDEDAGVVC	HHIPL1	761	Q96JK4
EIAHQGLDCDEEEEC	HORMAD2	256	Q8N7B1
GLDCDEEEECNDHIQ	HORMAD2	261	Q8N7B1
LHDAAENGELECCQI	ESPN	276	B1AK53
LCDGHLHCEDGSDEA	TMPRSS15	661	P98073
IDIHSCNHEAEKLGC	IGF1R	801	P08069
DQCEDIDECQHRHLC	LTBP1	1116	Q14766
EIHDDCLQAVGHECD	DGKA	306	P23743
VCDHDNDCQDGSDEH	LRP2	201	P98164
DGVDDCHDNSDEQLC	LRP2	1046	P98164
GSDEDRLLCENHHCD	LRP2	3581	P98164
ETDVNECDIPGHCQH	NOTCH2NLC	141	P0DPK4
DECSEGIIECHNHSR	NELL1	551	Q92832
QDIDECALGRHTCHA	HMCN1	5146	Q96RW7
GHLCECDDASCERHE	ITGB7	556	P26010
CECCQEAFEELHVHL	DBF4B	301	Q8NFT6
HEECRLEDGVQACHA	FCGBP	4836	Q9Y6R7
EDVDECEGNHRCQHG	FBN1	2566	P35555
AEDALIVHCVDDSGH	CHD1L	731	Q86WJ1
LAHLCEFIEDCEHTV	COPG2	436	Q9UBF2
VYLCGQDEEHKHCED	DSC1	831	Q08554
HNCDHAEDAGVICSK	CD163	246	Q86VB7
VDECAQGLDDCHADA	SCUBE2	46	Q9NQ36
HDGHNCLDVDECLEN	SCUBE2	121	Q9NQ36
DECVEGTDNCHIDAI	SCUBE3	31	Q8IX30
VDECEREDNAGCVHD	SCUBE3	71	Q8IX30
DGHNCLDVDECAEGN	SCUBE3	106	Q8IX30
EADREDEVEPGCHHI	IFT140	736	Q96RY7
HEHCCRGDVLDCLQD	AFP	266	P02771
HRGEFCEACQEGIVH	RTP1	186	P59025
CEACAAQEHRGHELV	TRIM47	201	Q96LD4
GHVGADDLCQECEDI	SFTPB	61	P07988
ICDVLLHDSDACANE	SYNE2	6086	Q8WXH0
CDNHDDGETAAIILC	MYCBP2	4261	O75592
SCHCDEENMGEHCDQ	HRC	641	P23327
AHICSHEEDAGVVCA	SSC5D	106	A1L4H1
KLHECRFHGCVDEDV	STON2	641	Q8WXE9
EEGDGDNVTCICDHL	ADGRF5	976	Q8IZF2
DECVIALHDCNGDVN	UBAP2L	66	Q14157
AQGSHCHEEEEEDNC	ZNF366	611	Q8N895
SICAEEKQHECHECE	ZNF484	271	Q5JVG2
DHDSEEICLDHLCKG	ZC3HAV1	506	Q7Z2W4
HQVHAIEFVCLEEGC	TRIM23	181	P36406
CCIDDVIHHEVKEIG	TRAPPC13	126	A5PLN9
AHLQEDQGEEECFHD	TTC1	51	Q99614
GIEVCVCNRGHHDDD	WBP1L	251	Q9NX94
EVEHCHGECVADTQL	WDR54	291	Q9H977