Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH2 domain binding	LILRA2 RACK1 SIGLEC10 SIGLEC11	1.49e-04	52	103	4	GO:0042169
GeneOntologyMolecularFunction	immune receptor activity	IL11RA EPOR IL12RB1 LILRA2 IL17RC CR1	2.15e-04	165	103	6	GO:0140375
GeneOntologyMolecularFunction	sialic acid binding	SELP SIGLEC10 SIGLEC11	2.82e-04	25	103	3	GO:0033691
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC RSPH9 STRCP1	4.07e-05	14	103	3	GO:0097732
GeneOntologyCellularComponent	kinocilium	STRC RSPH9 STRCP1	4.07e-05	14	103	3	GO:0060091
GeneOntologyCellularComponent	radial spoke 1	RSPH3 RSPH9	1.43e-04	4	103	2	GO:0120333
GeneOntologyCellularComponent	radial spoke 3	RSPH3 RSPH9	1.43e-04	4	103	2	GO:0120335
GeneOntologyCellularComponent	radial spoke head 1	RSPH3 RSPH9	1.43e-04	4	103	2	GO:0120336
GeneOntologyCellularComponent	radial spoke head 3	RSPH3 RSPH9	1.43e-04	4	103	2	GO:0120338
GeneOntologyCellularComponent	radial spoke head	RSPH3 RSPH9	2.38e-04	5	103	2	GO:0001535
GeneOntologyCellularComponent	external side of plasma membrane	SELP IL11RA EPOR IL12RB1 LILRA2 CUBN CR1 IGHD UMODL1 PKHD1	2.44e-04	519	103	10	GO:0009897
GeneOntologyCellularComponent	cell surface	SELP IL11RA EPOR IL12RB1 LILRA2 IL17RC CUBN CR1 IGHD UMODL1 PKHD1 TMEM102 STRC CEACAM20 STRCP1	3.49e-04	1111	103	15	GO:0009986
Domain	ig	IL11RA LILRA2 ICAM3 OBSCN IGHD SIGLEC10 SIGLEC11 CEACAM20	9.60e-06	190	102	8	PF00047
Domain	Immunoglobulin	IL11RA LILRA2 ICAM3 OBSCN IGHD SIGLEC10 SIGLEC11 CEACAM20	9.60e-06	190	102	8	IPR013151
Domain	Ig-like_fold	IL11RA EPOR IL12RB1 LILRA2 ADAMTSL1 ICAM3 OBSCN IGHD UMODL1 SIGLEC10 PKHD1 SIGLEC11 SEMA4A CEACAM20	2.93e-05	706	102	14	IPR013783
Domain	VPS13_C	VPS13C VPS13B	1.76e-04	4	102	2	PF16909
Domain	SHR-BD	VPS13C VPS13B	1.76e-04	4	102	2	IPR009543
Domain	VPS13_C	VPS13C VPS13B	1.76e-04	4	102	2	IPR031645
Domain	SHR-BD	VPS13C VPS13B	1.76e-04	4	102	2	PF06650
Domain	-	IL11RA EPOR IL12RB1 LILRA2 ADAMTSL1 ICAM3 OBSCN UMODL1 SIGLEC10 PKHD1 SIGLEC11 CEACAM20	2.64e-04	663	102	12	2.60.40.10
Domain	ATG_C	VPS13C VPS13B	2.92e-04	5	102	2	PF09333
Domain	Autophagy-rel_C	VPS13C VPS13B	2.92e-04	5	102	2	IPR015412
Domain	DH_1	OBSCN ARHGEF10L PLEKHG4B SOS2	3.90e-04	63	102	4	PS00741
Domain	RhoGEF	OBSCN ARHGEF10L PLEKHG4B SOS2	5.22e-04	68	102	4	SM00325
Domain	PH_dom-like	OBSCN DGKD EPS8L1 AGAP11 PHETA2 ARHGEF10L PLEKHG4B MAPK8IP2 SOS2	5.41e-04	426	102	9	IPR011993
Domain	RhoGEF	OBSCN ARHGEF10L PLEKHG4B SOS2	5.83e-04	70	102	4	PF00621
Domain	DH_2	OBSCN ARHGEF10L PLEKHG4B SOS2	5.83e-04	70	102	4	PS50010
Domain	DH-domain	OBSCN ARHGEF10L PLEKHG4B SOS2	6.15e-04	71	102	4	IPR000219
Domain	-	OBSCN ARHGEF10L PLEKHG4B SOS2	6.15e-04	71	102	4	1.20.900.10
Domain	VPS13_N	VPS13C VPS13B	8.09e-04	8	102	2	IPR026854
Domain	Chorein_N	VPS13C VPS13B	8.09e-04	8	102	2	PF12624
Domain	-	OBSCN DGKD AGAP11 PHETA2 ARHGEF10L PLEKHG4B MAPK8IP2 SOS2	1.36e-03	391	102	8	2.30.29.30
Domain	IG_LIKE	IL11RA LILRA2 ADAMTSL1 ICAM3 OBSCN IGHD SIGLEC10 SIGLEC11 CEACAM20	1.47e-03	491	102	9	PS50835
Domain	Ig-like_dom	IL11RA LILRA2 ADAMTSL1 ICAM3 OBSCN IGHD SIGLEC10 SIGLEC11 CEACAM20	1.73e-03	503	102	9	IPR007110
Domain	IGc2	LILRA2 ADAMTSL1 OBSCN SIGLEC10 SIGLEC11 CEACAM20	1.83e-03	235	102	6	SM00408
Domain	Ig_sub2	LILRA2 ADAMTSL1 OBSCN SIGLEC10 SIGLEC11 CEACAM20	1.83e-03	235	102	6	IPR003598
Domain	fn3	IL11RA EPOR IL12RB1 OBSCN UMODL1	1.95e-03	162	102	5	PF00041
Domain	IG	IL11RA LILRA2 ADAMTSL1 ICAM3 OBSCN SIGLEC10 SIGLEC11 CEACAM20	2.16e-03	421	102	8	SM00409
Domain	Ig_sub	IL11RA LILRA2 ADAMTSL1 ICAM3 OBSCN SIGLEC10 SIGLEC11 CEACAM20	2.16e-03	421	102	8	IPR003599
Domain	Dynein_HC_stalk	DNHD1 DYNC2H1	2.57e-03	14	102	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DYNC2H1	2.57e-03	14	102	2	IPR013602
Domain	DHC_N2	DNHD1 DYNC2H1	2.57e-03	14	102	2	PF08393
Domain	MT	DNHD1 DYNC2H1	2.57e-03	14	102	2	PF12777
Domain	Sushi	SELP PAMR1 CR1	2.88e-03	52	102	3	PF00084
Domain	DHC_fam	DNHD1 DYNC2H1	2.96e-03	15	102	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DYNC2H1	2.96e-03	15	102	2	IPR004273
Domain	Dynein_heavy	DNHD1 DYNC2H1	2.96e-03	15	102	2	PF03028
Domain	CCP	SELP PAMR1 CR1	3.21e-03	54	102	3	SM00032
Domain	FN3	IL11RA EPOR IL12RB1 OBSCN UMODL1	3.47e-03	185	102	5	SM00060
Domain	SUSHI	SELP PAMR1 CR1	3.55e-03	56	102	3	PS50923
Domain	Sushi_SCR_CCP_dom	SELP PAMR1 CR1	3.74e-03	57	102	3	IPR000436
Domain	Ig_I-set	ADAMTSL1 OBSCN SIGLEC10 SIGLEC11 CEACAM20	3.88e-03	190	102	5	IPR013098
Domain	I-set	ADAMTSL1 OBSCN SIGLEC10 SIGLEC11 CEACAM20	3.88e-03	190	102	5	PF07679
Domain	Ig/MHC_CS	IGHD SIGLEC10 SIGLEC11	3.92e-03	58	102	3	IPR003006
Domain	PH	OBSCN DGKD AGAP11 PHETA2 PLEKHG4B SOS2	4.21e-03	278	102	6	SM00233
Domain	PH_DOMAIN	OBSCN DGKD AGAP11 PHETA2 PLEKHG4B SOS2	4.29e-03	279	102	6	PS50003
Domain	IG_MHC	IGHD SIGLEC10 SIGLEC11	4.32e-03	60	102	3	PS00290
Domain	PH_domain	OBSCN DGKD AGAP11 PHETA2 PLEKHG4B SOS2	4.36e-03	280	102	6	IPR001849
Domain	FN3	IL11RA EPOR IL12RB1 OBSCN UMODL1	4.72e-03	199	102	5	PS50853
Domain	TSP_1	ADAMTSL1 ADGRB2 ADAMTS20	4.95e-03	63	102	3	PF00090
Domain	TSP1	ADAMTSL1 ADGRB2 ADAMTS20	5.41e-03	65	102	3	SM00209
Domain	TSP1_rpt	ADAMTSL1 ADGRB2 ADAMTS20	5.41e-03	65	102	3	IPR000884
Domain	TSP1	ADAMTSL1 ADGRB2 ADAMTS20	5.41e-03	65	102	3	PS50092
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1 OTOG	4.46e-06	11	106	3	31776257
Pubmed	The neuronal protein Kidins220/ARMS associates with ICAM-3 and other uropod components and regulates T-cell motility.	ICAM3 KIDINS220	9.20e-06	2	106	2	21381019
Pubmed	Ultrastructural localization of GPR179 and the impact of mutant forms on retinal function in CSNB1 patients and a mouse model.	GRM6 GPR179	9.20e-06	2	106	2	24084093
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	9.20e-06	2	106	2	34910522
Pubmed	Role of soluble P-selectin and methylenetetrahydrofolate reductase gene polymorphisms (677C>T) in Egyptian patients with venous thromboembolism.	SELP MTHFR	9.20e-06	2	106	2	22688557
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	9.20e-06	2	106	2	11687802
Pubmed	Genetic basis of tissue specificity of vasculitis in MRL/lpr mice.	IL11RA IL12RB1	9.20e-06	2	106	2	12746919
Pubmed	A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.	DYNC2H1 GOLGB1	9.20e-06	2	106	2	24046448
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1 OTOG	1.81e-05	17	106	3	20856818
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.76e-05	3	106	2	30801007
Pubmed	SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.	SIGLEC10 SIGLEC11	2.76e-05	3	106	2	24859880
Pubmed	The role of Siglec-G on B cells in autoimmune disease and leukemia.	SIGLEC10 SIGLEC11	2.76e-05	3	106	2	38042621
Pubmed	The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.	SIGLEC10 SIGLEC11	2.76e-05	3	106	2	24790146
Pubmed	Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.	SIGLEC10 SIGLEC11	2.76e-05	3	106	2	17572677
Pubmed	Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.	SIGLEC10 SIGLEC11	2.76e-05	3	106	2	23836061
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	DNHD1 KIDINS220 RACK1 PKHD1 GOLGB1 OTOG	4.42e-05	208	106	6	33230847
Pubmed	Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	17912374
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	5.50e-05	4	106	2	18849963
Pubmed	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	20200274
Pubmed	Siglec-G regulates B1 cell survival and selection.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	20729333
Pubmed	Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	30143587
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	DYNC2H1 OBSCN	5.50e-05	4	106	2	26147384
Pubmed	Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	24600033
Pubmed	Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	20038598
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13B	5.50e-05	4	106	2	15498460
Pubmed	Phosphorylation of HSF1 by PIM2 Induces PD-L1 Expression and Promotes Tumor Growth in Breast Cancer.	PIM2 HSF1	5.50e-05	4	106	2	31409638
Pubmed	Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	24695850
Pubmed	Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.	SIGLEC10 SIGLEC11	5.50e-05	4	106	2	25252961
Pubmed	Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese patients with Schubert-Bornschein congenital stationary night blindness.	GRM6 GPR179	5.50e-05	4	106	2	27428514
Pubmed	Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.	GRM6 GPR179	5.50e-05	4	106	2	22896717
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 ADGRB2 CUBN ADAMTS20	8.39e-05	75	106	4	20637190
Pubmed	LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina.	GRM6 GPR179	9.15e-05	5	106	2	31959619
Pubmed	CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	19264983
Pubmed	Complement-dependent P-selectin expression and injury following ischemic stroke.	SELP CR1	9.15e-05	5	106	2	17082645
Pubmed	Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	25987743
Pubmed	B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	32737150
Pubmed	A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	21623346
Pubmed	Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	36969253
Pubmed	The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	27548433
Pubmed	Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.	SIGLEC10 SIGLEC11	9.15e-05	5	106	2	26947073
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	9.15e-05	5	106	2	24920589
Pubmed	Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.	RSPH3 RSPH9	1.37e-04	6	106	2	34871179
Pubmed	Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.	GRM6 GPR179	1.37e-04	6	106	2	23714322
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC10 SIGLEC11	1.37e-04	6	106	2	14559209
Pubmed	GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.	GRM6 GPR179	1.37e-04	6	106	2	24790204
Pubmed	NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans.	ERCC4 NR1H2	1.37e-04	6	106	2	18026184
Pubmed	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	SELP IL12RB1 NOD1 MTHFR	1.85e-04	92	106	4	19247692
Pubmed	GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.	RACK1 SOS2	1.91e-04	7	106	2	10820259
Pubmed	LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.	GRM6 GPR179	1.91e-04	7	106	2	25997951
Pubmed	Arf4 is required for Mammalian development but dispensable for ciliary assembly.	PKHD1 GOLGB1	1.91e-04	7	106	2	24586199
Pubmed	Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma.	EPOR SOS2	1.91e-04	7	106	2	15953601
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	SELP IL12RB1 ERCC4 NOD1 MTHFR	2.27e-04	179	106	5	19074885
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	2.55e-04	8	106	2	21165971
Pubmed	Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue distribution.	SELP CR1	2.55e-04	8	106	2	7898049
Pubmed	Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.	CUBN MTHFR	2.55e-04	8	106	2	19303062
Pubmed	Phagocytosis imprints heterogeneity in tissue-resident macrophages.	SELP NR1H2	2.55e-04	8	106	2	28432199
Pubmed	Rhythmic modulation of the hematopoietic niche through neutrophil clearance.	SELP NR1H2	2.55e-04	8	106	2	23706740
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	EPN3 DNHD1 DYNC2H1 VPS13C EPS8L1 CUBN CR1 RACK1 GLB1 SLC12A9 PKHD1	2.78e-04	1016	106	11	19056867
Pubmed	The composition and signaling of the IL-35 receptor are unconventional.	IL11RA IL12RB1	3.27e-04	9	106	2	22306691
Pubmed	Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.	SIGLEC10 SIGLEC11	3.27e-04	9	106	2	23374343
Pubmed	Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.	GRM6 GPR179	3.27e-04	9	106	2	30282023
Pubmed	Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.	CUBN MTHFR	3.27e-04	9	106	2	19744961
Pubmed	The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex.	EPOR RACK1	4.08e-04	10	106	2	12960323
Pubmed	CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.	RSPH3 RSPH9	4.08e-04	10	106	2	34792097
Pubmed	The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.	RACK1 INCA1	4.08e-04	10	106	2	21750715
Pubmed	Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.	RACK1 INCA1	4.08e-04	10	106	2	15159402
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC10 SIGLEC11	4.08e-04	10	106	2	25320078
Pubmed	Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.	SELP MTHFR	4.08e-04	10	106	2	16928730
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	SOX15 CUBN NR1H2 PAX4	4.79e-04	118	106	4	16971476
Pubmed	The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.	GRM6 GPR179	4.97e-04	11	106	2	28262416
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	4.97e-04	11	106	2	31448880
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	TRIM15 PIM2 CENPL DYNC2H1 VPS13C RACK1 PI4KA HSF1 GOLGB1	5.10e-04	754	106	9	35906200
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZSWIM8 APEH SYNPO ARID1A ARCN1 TRIM66 USP2 NR1H2 HECTD1 MAPK8IP2 LRRFIP1 SOS2	5.53e-04	1285	106	12	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPN3 ZNF316 OBSCN ADGRB2 APEH ARID1A ARHGEF10L MTHFR PI4KA ZNF398 HECTD1	5.62e-04	1105	106	11	35748872
Pubmed	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	CUBN MTHFR	5.95e-04	12	106	2	20852008
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC10 SIGLEC11	7.02e-04	13	106	2	35921817
Pubmed	p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.	GATA6 RACK1	7.02e-04	13	106	2	16458891
Pubmed	Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.	ADGRB2 MAPK8IP2	7.02e-04	13	106	2	12508107
Pubmed	Multiple loci influencing hippocampal degeneration identified by genome scan.	SELP VPS13B	7.02e-04	13	106	2	22745009
Pubmed	Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.	APEH GLB1	7.02e-04	13	106	2	10508511
Pubmed	Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.	GRM6 GPR179	7.02e-04	13	106	2	36179691
Pubmed	Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.	SELP CUBN NR1H2	7.90e-04	59	106	3	20855565
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	DNHD1 ADAMTSL1 PAMR1 IL17RC XYLT2 SIGLEC10 FAM124A SIGLEC11 SEMA4A CEACAM20	8.71e-04	985	106	10	12975309
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	VPS13C WDR81 KIDINS220 PI4KA RAB11FIP5 VPS13B GOLGB1	9.14e-04	504	106	7	34432599
Pubmed	The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.	SIGLEC10 SIGLEC11	9.41e-04	15	106	2	22496360
Pubmed	T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.	EPN3 XYLT2	1.07e-03	16	106	2	32675240
Pubmed	Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.	SELP BAZ2A	1.07e-03	16	106	2	12781685
Pubmed	A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.	EPOR ARID1A	1.21e-03	17	106	2	16287714
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ARID1A KIDINS220 RAB11FIP5 VPS13B GOLGB1	1.30e-03	263	106	5	34702444
Pubmed	NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA.	PI4KA HECTD1 LRRFIP1	1.30e-03	70	106	3	31751430
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	WDR81 DGKD	1.36e-03	18	106	2	24068962
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	DYNC2H1 VPS13C	1.36e-03	18	106	2	27984743
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	ERCC4 IL17RC ARHGEF10L VPS13B	1.39e-03	157	106	4	12466305
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	ARCN1 KIDINS220 RACK1 HECTD1 LRRFIP1	1.43e-03	269	106	5	29511261
Pubmed	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.	CUBN MTHFR	1.69e-03	20	106	2	23824729
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EPN3 EPS8L1 KIDINS220 RACK1 PI4KA GOLGB1 LRRFIP1	1.76e-03	565	106	7	25468996
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ERCC4 PRAMEF22 SGPP2 OBSCN GATA6 CUBN RACK1 PI4KA VPS13B GOLGB1	1.78e-03	1084	106	10	11544199
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	ADGRB2 GRM6 ADGRD2	1.84e-03	79	106	3	12679517
Pubmed	Report of the sixth international workshop on human chromosome 3 mapping 1995.	APEH GLB1	1.86e-03	21	106	2	8641130
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	CUBN PKHD1	1.86e-03	21	106	2	27591083
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL11RA IL12RB1 IL17RC	4.82e-04	42	66	3	602
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP PAMR1 CR1	1.18e-03	57	66	3	1179
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ARHGEF10L SOS2	1.80e-03	66	66	3	722
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 OBSCN SIGLEC11 CEACAM20	2.84e-03	161	66	4	593
Drug	Beta-sistosterol [83-46-5]; Up 200; 9.6uM; PC3; HT_HG-U133A	SELP ERCC4 ADGRB2 IL17RC TESPA1 TRIM66 USP2 HSF1 SOS2	3.20e-07	200	103	9	4073_UP
Drug	MK-886; Down 200; 1uM; MCF7; HG-U133A	EPOR LILRA2 TCP11L1 CUBN XYLT2 KBTBD4 PAX4 SOS2	3.46e-06	199	103	8	264_DN
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.21e-05	2	103	2	DOID:0110471 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13B	3.61e-05	3	103	2	DOID:0111590 (implicated_via_orthology)
Disease	Klatskin's tumor (is_implicated_in)	GATA6 ARID1A	1.20e-04	5	103	2	DOID:4927 (is_implicated_in)
Disease	Night blindness, congenital stationary, type 1	GRM6 GPR179	7.78e-04	12	103	2	C3501847
Disease	Night Blindness, Congenital Stationary, Type 1A	GRM6 GPR179	7.78e-04	12	103	2	C3495587
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	GRM6 GPR179	7.78e-04	12	103	2	C1864877
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	GRM6 GPR179	7.78e-04	12	103	2	C1850362
Disease	X-Linked Csnb	GRM6 GPR179	7.78e-04	12	103	2	C3711543
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	GRM6 GPR179	7.78e-04	12	103	2	C1848172
Disease	tetralogy of Fallot (is_implicated_in)	GATA6 MTHFR	9.18e-04	13	103	2	DOID:6419 (is_implicated_in)
Disease	Cone-rod synaptic disorder, congenital nonprogressive	GRM6 GPR179	9.18e-04	13	103	2	C4041558
Disease	anemia (is_implicated_in)	EPOR MTHFR	1.07e-03	14	103	2	DOID:2355 (is_implicated_in)
Disease	Replication Error Phenotype	ARID1A MTHFR	1.23e-03	15	103	2	C1721098
Disease	Microsatellite Instability	ARID1A MTHFR	1.23e-03	15	103	2	C0920269
Disease	Malignant neoplasm of breast	EPOR CTU2 DYNC2H1 OBSCN CUBN ARID1A GRM6 MTHFR VPS13B GOLGB1 LRRFIP1	1.33e-03	1074	103	11	C0006142
Disease	Monogenic diabetes	GATA6 PAX4	1.40e-03	16	103	2	C3888631
Disease	urolithiasis	DGKD VPS13B HCRTR2	1.41e-03	63	103	3	MONDO_0024647
Disease	Night blindness, congenital stationary	GRM6 GPR179	1.59e-03	17	103	2	C0339535
Disease	melanoma	EPOR ERCC4 CUBN ADAMTS20 PAX4	1.81e-03	248	103	5	C0025202
Disease	small cell lung carcinoma	ADAMTSL1 DYNC2H1 IL17RC	2.79e-03	80	103	3	EFO_0000702

Protein segments in the cluster

Peptide	Gene	Start	Entry
ECWATPSSNARDPIT	UMODL1	1156	Q5DID0
IASGCSWTLENPDPT	ADGRB2	61	O60241
AAPWNSVLVTPTSDC	FAM222A	346	Q5U5X8
TLLSLEDAVWASCGP	ARHGEF10L	976	Q9HCE6
GKWPSLATSACAPIS	AGAP11	181	Q8TF27
PVPESHACALAWLDT	ALDH16A1	21	Q8IZ83
EPLFTSSLWGPSCDE	AZIN1	346	O14977
SDLQIRGWTCPSPDS	BAZ2A	1531	Q9UIF9
LSASLCTVWSPPAAA	CEACAM20	16	Q6UY09
LAPPSTHCSADPWDI	EPN3	311	Q9H201
WTCLPSAAGAPALAS	CFAP46	2596	Q8IYW2
IASSEPSLSPAACWI	DNHD1	1626	Q96M86
PESLSPCELHTCASW	ADAMTS20	1066	P59510
SPVHTDLLWASLPEC	NWD1	516	Q149M9
GTPAASWCLLESDVS	NPFFR2	6	Q9Y5X5
AEPPQCTSLAWSADG	RACK1	281	P63244
APWAASSAAACELVL	RAB11FIP5	96	Q9BXF6
LSSEWSAPSDPLDIL	LILRA2	301	Q8N149
WAVCPSAEAQDPFST	ARID1A	2091	O14497
ATALVSASSPCPQAW	IL11RA	16	Q14626
TCLPWNDEPLAAETS	MTHFR	451	P42898
CSLIASSPEENWPAC	KIDINS220	1656	Q9ULH0
VCARHSWASDAPSEP	LINS1	586	Q8NG48
PATELESPAEECSWA	JMY	216	Q8N9B5
SVCPWETTAPADSVS	GPR179	1956	Q6PRD1
ELFDPSSCPGEWLSE	HIPK4	561	Q8NE63
SSCPGEWLSEPDCTL	HIPK4	566	Q8NE63
VRPASWQETALCSPA	MAPK8IP2	161	Q13387
LEWAPCSSDDPELCA	GLB1	621	P16278
SEEPSFIPEAWSACT	ADAMTSL1	521	Q8N6G6
VETPLPSERCSSHWA	FAM124A	441	Q86V42
VSDPDTDALICWSPS	HSF1	26	Q00613
SCNTLHTRDWASPDP	FAM214B	151	Q7L5A3
ADAPELSHVLCWAPT	PI4KA	1601	P42356
SDLDLSRVPDSSCPW	NOD1	291	Q9Y239
SFCDDAWPSVLVQPA	POM121L12	246	Q8N7R1
QPSGLSLASEDPWSC	NHLRC2	411	Q8NBF2
SWPVDCTLDGLFPAS	ICAM3	236	P32942
LCWATAPERCLSDTP	PAX4	281	O43316
PSCVDVAWPCLDASL	PAX4	316	O43316
SSCLQCPWLTEEGPA	OBSCN	7916	Q5VST9
PEDSSCRWAATPQDS	P2RY4	341	P51582
SWVLAPASCFLDPNS	PRSS36	356	Q5K4E3
LEDSPPCRNWSSASE	HCRTR2	6	O43614
SSDPDVPFSICTWVI	CUBN	3296	O60494
SPAEVTSSVRPDSWC	GATA6	576	Q92908
VCPFLIDPSSQATEW	DYNC2H1	3276	Q8NCM8
DCSLNEPGSTATWPL	HECTD1	1186	Q9ULT8
WSGDPHEVPSSLCSL	GRM6	506	O15303
WSVPCSPQSLDISFA	CENPL	241	Q8N0S6
PFSITCLDNLVWSSP	CR1	531	P17927
PFSITCLDNLVWSSP	CR1	981	P17927
CNLELLASSDPPVWA	PIK3CD-AS1	91	Q5SR53
ASSDPPEAASWLLCE	IGHD	281	P01880
SVSVDWAPSLLSTCP	IL12RB1	461	P42701
SGHWSAPLPTCEAIS	SELP	371	P16109
LADTPWLCQSAEPGD	DGKD	1086	Q16760
WCSLPTADTSSFVPL	EPOR	106	P19235
PRWDSCDSLNGLDPS	EPS8L1	576	Q8TE68
WCLPSNDITSDVSPN	DYNAP	61	Q8N1N2
ESFIPLTINCWPSES	ARCN1	371	P48444
EVFSLPPSVLWCSAQ	CTU2	151	Q2VPK5
TLQSWLLDAPCSLPA	IL17RC	381	Q8NAC3
TRTPLEPSNCWSDLD	LRRFIP1	401	Q32MZ4
SWEPTAPSDICTAET	PAMR1	651	Q6UXH9
SPWSPLDQEEACASR	INCA1	191	Q0VD86
GSSWAAVECPDTLDP	OTOG	1141	Q6ZRI0
AFWDCLSVQLSEDPP	TCP11L1	111	Q9NUJ3
SLNCTEWSLLPPATE	RSPH9	76	Q9H1X1
FCLPSHTVDPSEWAE	RNF157	171	Q96PX1
SDWLRDISTCPNSPS	SOS2	1246	Q07890
PAAAEEVVPEWASCL	SYNPO	686	Q8N3V7
FTRLCLPEAWSSAPS	KBTBD4	451	Q9NVX7
WSPLSDSVTCPLEVA	PIM2	71	Q9P1W9
EASSACSTDWVIPDP	NR1H2	51	P55055
TIWSGARPLSCSPEA	PRAMEF22	116	A3QJZ6
WDPESRTCCLLSAPN	SEMA4A	516	Q9H3S1
NLTEASIWCETLPAP	PKHD1	1241	P08F94
PSDCVLAADWLPSLL	STRC	166	Q7RTU9
WTFIDCLDSASPLFP	SGPP2	236	Q8IWX5
PQPWDRSSAVACISL	SNAI3	56	Q3KNW1
PFSSDCLPDLSVWAE	APEH	636	P13798
WDCASPDPAALFSVA	ADGRD2	151	Q7Z7M1
APSILCSVPWDACEL	SHANK2-AS3	31	Q9BTD1
PDRTLGCWATDAAPA	RSPH3	56	Q86UC2
AWSLEPPAATAAASS	SOX15	11	O60248
PVSPETSCFSTLHDW	PHETA2	216	Q6ICB4
PAHSPWSSDIRACVE	PLEKHG4B	1226	Q96PX9
PAPTSEWDSECLTSL	ZNF398	6	Q8TD17
AVDLSCLSLEWASAP	SLC12A9	431	Q9BXP2
CWASTSPGTDLPLSE	TRIM15	396	Q9C019
PSEAREAWPTLCSAQ	TMEM102	251	Q8N9M5
IASSECLPFWPESLS	VPS13C	2901	Q709C8
FLCPDLEEQSPTWAA	NEURL3	96	Q96EH8
LSSTEPPAAAEWACL	ZSWIM8	321	A7E2V4
PAALAEEESPWICSD	ZNF316	681	A6NFI3
ASCLDWPVPAFDIIT	UBR3	1701	Q6ZT12
APGADSSQCWSLPAI	VPS13B	3191	Q7Z7G8
PSDCVLAADWLPSLL	STRCP1	166	A6NGW2
CTHSLPIEDPQWSTD	TESPA1	391	A2RU30
LWCPSPHATAELFEE	ERCC4	801	Q92889
CSTVFDPFWDLSLPI	USP2	431	O75604
CAADSQPPATLSWVL	SIGLEC10	276	Q96LC7
LLETSCNTDPGSPWS	TRIM66	231	O15016
SAPWDLPSTPCAEEA	WDR86	146	Q86TI4
LCAADSQPPATLSWV	SIGLEC11	286	Q96RL6
LEPCRLTSWSSLSPD	XYLT2	836	Q9H1B5
PVLEATPCEASWTRD	WDR81	636	Q562E7
PERVASDSWTECTLP	TTLL13	766	A6NNM8
ESNLCPDWPSHSEDA	GOLGB1	1281	Q14789