Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sialic acid binding	SELE SELP SIGLEC14	1.20e-05	25	36	3	GO:0033691
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A1 SLC5A7 SLC17A5 SLC5A6	6.10e-05	119	36	4	GO:0015294
GeneOntologyMolecularFunction	symporter activity	SLC6A1 SLC5A7 SLC17A5 SLC5A6	1.49e-04	150	36	4	GO:0015293
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL SLC5A6	1.93e-04	301	36	5	GO:0022853
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A1 SLC5A7 CNGA3 SLC5A6	2.47e-04	171	36	4	GO:0015081
GeneOntologyMolecularFunction	monocarboxylate:sodium symporter activity	SLC6A1 SLC5A6	3.27e-04	15	36	2	GO:0140161
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL ANO5 CNGA3 SLC5A6	3.52e-04	758	36	7	GO:0015318
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A1 SLC5A7 SLC5A6	4.17e-04	81	36	3	GO:0015370
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL ANO5 CNGA3 SLC5A6	4.62e-04	793	36	7	GO:0015075
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC6A1 SLC5A6	5.30e-04	19	36	2	GO:0015355
GeneOntologyMolecularFunction	oligosaccharide binding	SELE SELP	5.88e-04	20	36	2	GO:0070492
GeneOntologyMolecularFunction	monosaccharide binding	SELP ALKBH3 SIGLEC14	6.65e-04	95	36	3	GO:0048029
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL CNGA3 SLC5A6	8.16e-04	627	36	6	GO:0022890
GeneOntologyMolecularFunction	carboxylic acid binding	SELE SELP ALKBH3 SIGLEC14	8.73e-04	239	36	4	GO:0031406
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL ANO5 SVOP CNGA3 SLC5A6	9.95e-04	1180	36	8	GO:0022857
GeneOntologyMolecularFunction	organic acid binding	SELE SELP ALKBH3 SIGLEC14	1.09e-03	254	36	4	GO:0043177
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL CNGA3 SLC5A6	1.10e-03	664	36	6	GO:0008324
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL SLC5A6	1.56e-03	477	36	5	GO:0022804
GeneOntologyMolecularFunction	transporter activity	SLC6A1 SLC5A7 SLC17A5 ATP5MGL ANO5 SVOP CNGA3 SLC5A6	1.76e-03	1289	36	8	GO:0005215
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A1 SLC5A6	1.81e-03	35	36	2	GO:0005343
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A1 SLC5A7 SLC17A5 SLC5A6	1.92e-03	296	36	4	GO:0015291
GeneOntologyMolecularFunction	carbohydrate binding	SELE SELP ALKBH3 SIGLEC14	2.27e-03	310	36	4	GO:0030246
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC6A1 ANO5 SLC5A6	2.52e-03	151	36	3	GO:0008509
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC6A1 ANO5 SLC5A6	3.58e-03	171	36	3	GO:0015103
GeneOntologyMolecularFunction	O-acyltransferase activity	CPT2 MBOAT2	5.07e-03	59	36	2	GO:0008374
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC6A1 SLC17A5 SLC5A6	6.09e-03	207	36	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC6A1 SLC17A5 SLC5A6	6.18e-03	208	36	3	GO:0005342
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A1 SLC5A7 CNGA3 SLC5A6	9.49e-03	465	36	4	GO:0046873
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLC6A1 SLC5A6	1.15e-02	90	36	2	GO:0008028
MousePheno	decreased mast cell number	SELE SELP NDST2	7.88e-06	18	31	3	MP:0000336
MousePheno	abnormal mast cell number	SELE SELP NDST2	2.79e-05	27	31	3	MP:0020203
MousePheno	abnormal mast cell morphology	SELE SELP NDST2	1.07e-04	42	31	3	MP:0000359
MousePheno	spinning	SELE SELP	2.12e-04	10	31	2	MP:0001411
Domain	Selectin_superfamily	SELE SELP	1.08e-05	3	36	2	IPR002396
Domain	NA_SOLUT_SYMP_1	SLC5A7 SLC5A6	1.97e-04	11	36	2	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A7 SLC5A6	2.36e-04	12	36	2	PS00457
Domain	SSF	SLC5A7 SLC5A6	2.36e-04	12	36	2	PF00474
Domain	Na/solute_symporter	SLC5A7 SLC5A6	2.36e-04	12	36	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A7 SLC5A6	2.36e-04	12	36	2	PS50283
Domain	EGF	SELE SELP F12	1.82e-03	126	36	3	PF00008
Domain	-	ROS1 HHIPL1	2.56e-03	39	36	2	2.120.10.30
Domain	C-type_lectin_CS	SELE SELP	3.10e-03	43	36	2	IPR018378
Domain	6-blade_b-propeller_TolB-like	ROS1 HHIPL1	3.54e-03	46	36	2	IPR011042
Domain	Sushi	SELE SELP	4.51e-03	52	36	2	PF00084
Domain	CCP	SELE SELP	4.85e-03	54	36	2	SM00032
Domain	SUSHI	SELE SELP	5.21e-03	56	36	2	PS50923
Domain	Sushi_SCR_CCP_dom	SELE SELP	5.39e-03	57	36	2	IPR000436
Domain	Ig_2	CEACAM16 SIGLEC14	8.71e-03	73	36	2	PF13895
Domain	MFS	SLC17A5 SVOP	9.65e-03	77	36	2	IPR011701
Domain	MFS_1	SLC17A5 SVOP	9.65e-03	77	36	2	PF07690
Domain	EGF_3	SELE SELP F12	1.03e-02	235	36	3	PS50026
Domain	EGF	SELE SELP F12	1.03e-02	235	36	3	SM00181
Domain	C_TYPE_LECTIN_1	SELE SELP	1.04e-02	80	36	2	PS00615
Domain	Lectin_C	SELE SELP	1.14e-02	84	36	2	PF00059
Domain	CLECT	SELE SELP	1.14e-02	84	36	2	SM00034
Domain	C_TYPE_LECTIN_2	SELE SELP	1.17e-02	85	36	2	PS50041
Domain	C-type_lectin-like	SELE SELP	1.19e-02	86	36	2	IPR001304
Domain	EGF-like_dom	SELE SELP F12	1.21e-02	249	36	3	IPR000742
Domain	EGF_1	SELE SELP F12	1.29e-02	255	36	3	PS00022
Domain	EGF-like_CS	SELE SELP F12	1.37e-02	261	36	3	IPR013032
Domain	EGF_2	SELE SELP F12	1.43e-02	265	36	3	PS01186
Domain	-	SELE SELP	1.50e-02	97	36	2	3.10.100.10
Domain	C-type_lectin-like/link	SELE SELP	1.56e-02	99	36	2	IPR016186
Pathway	BIOCARTA_MONOCYTE_PATHWAY	SELE SELP	1.78e-04	11	26	2	MM1436
Pathway	BIOCARTA_MONOCYTE_PATHWAY	SELE SELP	1.78e-04	11	26	2	M4956
Pathway	WP_PLATELETMEDIATED_INTERACTIONS_WITH_VASCULAR_AND_CIRCULATING_CELLS	SELE SELP	4.37e-04	17	26	2	M39807
Pubmed	Macrophages, not neutrophils, infiltrate skeletal muscle in mice deficient in P/E selectins after mechanical reloading.	SELE SELP	1.10e-06	2	37	2	12829442
Pubmed	Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness).	SELE SELP	1.10e-06	2	37	2	11053286
Pubmed	Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow.	SELE SELP	1.10e-06	2	37	2	15367439
Pubmed	Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis.	SELE SELP	1.10e-06	2	37	2	11981814
Pubmed	Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.	SELE SELP	1.10e-06	2	37	2	8598043
Pubmed	Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses.	SELE SELP	1.10e-06	2	37	2	17456770
Pubmed	Anti-P- and E-selectin therapy prevents abortion in the CBA/J x DBA/2J combination by blocking the migration of Th1 lymphocytes into the foetal-maternal interface.	SELE SELP	1.10e-06	2	37	2	16579979
Pubmed	E-selectin gene S128R polymorphism is associated with poor prognosis in patients with stage II or III colorectal cancer.	SELE SELP	1.10e-06	2	37	2	19361981
Pubmed	Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation.	SELE SELP	1.10e-06	2	37	2	9746773
Pubmed	Migration of activated CD8(+) T lymphocytes to sites of viral infection does not require endothelial selectins.	SELE SELP	1.10e-06	2	37	2	10666212
Pubmed	Circulating levels of P-selectin and E-selectin relate to cardiovascular magnetic resonance-derived aortic characteristics in young adults from the general population, a cross-sectional study.	SELE SELP	1.10e-06	2	37	2	30068374
Pubmed	E and P selectins are not required for resistance to severe murine lyme arthritis.	SELE SELP	1.10e-06	2	37	2	9712820
Pubmed	The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo.	SELE SELP	1.10e-06	2	37	2	15466915
Pubmed	The selectins E and P in normal labour. A preliminary report on evaluation of their prognostic values for preeclampsia.	SELE SELP	1.10e-06	2	37	2	18217430
Pubmed	Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice.	SELE SELP	1.10e-06	2	37	2	10447722
Pubmed	E-selectin and P-selectin expression in endothelium of leprosy skin lesions.	SELE SELP	1.10e-06	2	37	2	26051909
Pubmed	Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow.	SELE SELP	1.10e-06	2	37	2	23499761
Pubmed	Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation.	SELE SELP	1.10e-06	2	37	2	12881311
Pubmed	Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines.	SELE SELP	1.10e-06	2	37	2	12096034
Pubmed	A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late-phase inflammation in contact sensitivity.	SELE SELP	1.10e-06	2	37	2	15117973
Pubmed	Regulatory T cells dynamically regulate selectin ligand function during multiple challenge contact hypersensitivity.	SELE SELP	1.10e-06	2	37	2	25274531
Pubmed	E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung.	SELE SELP	1.10e-06	2	37	2	20010946
Pubmed	Heterogeneous effect of two selectin gene polymorphisms on coronary artery disease risk: a meta-analysis.	SELE SELP	1.10e-06	2	37	2	24498435
Pubmed	Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha.	SELE SELP	1.10e-06	2	37	2	1378846
Pubmed	Angiogenesis in P- and E-selectin-deficient mice.	SELE SELP	1.10e-06	2	37	2	9789257
Pubmed	E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis.	SELE SELP	1.10e-06	2	37	2	16936251
Pubmed	Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins.	BACE1 CHRM2	1.10e-06	2	37	2	16181410
Pubmed	Th1 cell-mediated resistance to cutaneous infection with Leishmania major is independent of P- and E-selectins.	SELE SELP	1.10e-06	2	37	2	14568948
Pubmed	Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.	SELE SELP	1.10e-06	2	37	2	8642341
Pubmed	Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin.	SELE SELP	1.10e-06	2	37	2	8874194
Pubmed	Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.	SELE SELP	1.10e-06	2	37	2	8647940
Pubmed	Increased soluble selectins as a reflection of activated platelets and endothelium in Legg-Calve-Perthes disease.	SELE SELP	1.10e-06	2	37	2	25000467
Pubmed	Selectins mediate small cell lung cancer systemic metastasis.	SELE SELP	1.10e-06	2	37	2	24699516
Pubmed	Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin.	SELE SELP	1.10e-06	2	37	2	10477616
Pubmed	Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation.	SELE SELP	1.10e-06	2	37	2	21544708
Pubmed	E- and P-selectins are essential for the development of cockroach allergen-induced airway responses.	SELE SELP	1.10e-06	2	37	2	12165540
Pubmed	Serum adhesion molecules in acute pancreatitis: time course and early assessment of disease severity.	SELE SELP	1.10e-06	2	37	2	18580442
Pubmed	Host defense against systemic infection with Streptococcus pneumoniae is impaired in E-, P-, and E-/P-selectin-deficient mice.	SELE SELP	1.10e-06	2	37	2	9329976
Pubmed	Soluble selectin levels in patients with lung cancer.	SELE SELP	1.10e-06	2	37	2	11936588
Pubmed	New discoveries with mice mutant in endothelial and platelet selectins.	SELE SELP	1.10e-06	2	37	2	10605793
Pubmed	Differential expression of E- and P-selectin in the microvasculature of sickle cell transgenic mice.	SELE SELP	1.10e-06	2	37	2	15280076
Pubmed	Subset-specific reductions in lung lymphocyte accumulation following intratracheal antigen challenge in endothelial selectin-deficient mice.	SELE SELP	1.10e-06	2	37	2	12193727
Pubmed	E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.	SELE SELP	1.10e-06	2	37	2	18056394
Pubmed	Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells.	SELE SELP	1.10e-06	2	37	2	15676218
Pubmed	E and P Selectins as Potential Markers in the Assessment of the Severity of Acute Pancreatitis.	SELE SELP	1.10e-06	2	37	2	29517629
Pubmed	Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia.	SELE SELP	1.10e-06	2	37	2	17939599
Pubmed	Accelerated development of arthritis in mice lacking endothelial selectins.	SELE SELP	1.10e-06	2	37	2	16207337
Pubmed	Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.	SELE SELP	3.30e-06	3	37	2	10500197
Pubmed	Higher-affinity oligosaccharide ligands for E-selectin.	SELE SELP	3.30e-06	3	37	2	7680663
Pubmed	Role of selectins in the triggering, growth, and dissemination of T-lymphoma cells: implication of L-selectin in the growth of thymic lymphoma.	SELE SELP	3.30e-06	3	37	2	15705798
Pubmed	E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model.	SELE SELP	3.30e-06	3	37	2	23922938
Pubmed	Maspin, E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters.	SELE SELP	3.30e-06	3	37	2	18597952
Pubmed	The selectins: vascular adhesion molecules.	SELE SELP	3.30e-06	3	37	2	7542213
Pubmed	Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature.	SELE SELP	3.30e-06	3	37	2	14507656
Pubmed	Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice.	SELE SELP	3.30e-06	3	37	2	11468173
Pubmed	The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.	SELE SELP	3.30e-06	3	37	2	22681228
Pubmed	Candidate gene analysis of selectin cluster in patients with multiple sclerosis.	SELE SELP	3.30e-06	3	37	2	19240957
Pubmed	P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand.	SELE SELP	3.30e-06	3	37	2	19177138
Pubmed	Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.	SELE SELP	3.30e-06	3	37	2	9128259
Pubmed	Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis.	SELE SELP	3.30e-06	3	37	2	12505044
Pubmed	The roles of P- and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas.	SELE SELP	3.30e-06	3	37	2	21889879
Pubmed	Does colorectal cancer clinical advancement affect adhesion molecules (sP-selectin, sE-selectin and ICAM-1) concentration?	SELE SELP	3.30e-06	3	37	2	19136145
Pubmed	β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.	SELE SELP	3.30e-06	3	37	2	23235150
Pubmed	Intestinal inflammation in adhesion molecule-deficient mice: an assessment of P-selectin alone and in combination with ICAM-1 or E-selectin.	SELE SELP	3.30e-06	3	37	2	10410991
Pubmed	Cell-cell contact mechanisms.	SELE SELP	3.30e-06	3	37	2	1375831
Pubmed	Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics.	SELE SELP	3.30e-06	3	37	2	15299021
Pubmed	P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.	SELE SELP	3.30e-06	3	37	2	11071658
Pubmed	P-selectin, and not E-selectin, negatively regulates murine megakaryocytopoiesis.	SELE SELP	3.30e-06	3	37	2	12370396
Pubmed	Effect of extracellular pH on selectin adhesion: theory and experiment.	SELE SELP	3.30e-06	3	37	2	23442851
Pubmed	Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy.	SELE SELP	3.30e-06	3	37	2	34433625
Pubmed	PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.	SELE SELP	3.30e-06	3	37	2	24740164
Pubmed	Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion.	SELE SELP	3.30e-06	3	37	2	9612391
Pubmed	Plasma selectins in patients with obstructive sleep apnea.	SELE SELP	3.30e-06	3	37	2	22836626
Pubmed	Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: endothelial cell interactions under flow conditions.	SELE SELP	3.30e-06	3	37	2	21159528
Pubmed	Selectin-mediated recruitment of bone marrow stromal cells in the postischemic cerebral microvasculature.	SELE SELP	3.30e-06	3	37	2	21257828
Pubmed	Selectins: a family of adhesion receptors.	SELE SELP	3.30e-06	3	37	2	1717161
Pubmed	T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice.	SELE SELP	3.30e-06	3	37	2	12391189
Pubmed	Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence.	SELE SELP	3.30e-06	3	37	2	10841555
Pubmed	Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice.	SELE SELP	3.30e-06	3	37	2	11050049
Pubmed	Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition.	SELE SELP	3.30e-06	3	37	2	12707029
Pubmed	Patients with an Inflamed Atherosclerotic Plaque have Increased Levels of Circulating Inflammatory Markers.	SELE SELP	3.30e-06	3	37	2	27237221
Pubmed	Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion.	SELE SELP	3.30e-06	3	37	2	14568956
Pubmed	Lectin adhesion proteins (P-, L- and E-selectins) as biomarkers in colorectal cancer.	SELE SELP	3.30e-06	3	37	2	27775438
Pubmed	Periprocedural soluble P- and E-selectin levels fail as predictors of clinical restenosis in patients treated with elective coronary stenting.	SELE SELP	3.30e-06	3	37	2	17143564
Pubmed	Role of primary and secondary capture for leukocyte accumulation in vivo.	SELE SELP	3.30e-06	3	37	2	9440702
Pubmed	L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells.	SELE SELP	3.30e-06	3	37	2	14592723
Pubmed	Selectin synthesis and inflammation.	SELE SELP	3.30e-06	3	37	2	8851663
Pubmed	Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice.	SELE SELP	3.30e-06	3	37	2	11120753
Pubmed	Selectins in human amniotic fluid and cord blood plasma. A preliminary report.	SELE SELP	3.30e-06	3	37	2	20580062
Pubmed	A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions.	SELE SELP	3.30e-06	3	37	2	15304396
Pubmed	P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin.	SELE SELP	3.30e-06	3	37	2	9564894
Pubmed	Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy.	SELE SELP	3.30e-06	3	37	2	16779968
Pubmed	Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography.	SELE SELP	3.30e-06	3	37	2	22068558
Pubmed	No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules.	SELE SELP	3.30e-06	3	37	2	18381812
Pubmed	Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.	SELE SELP	3.30e-06	3	37	2	15086468
Pubmed	Differentiated serum levels of Krüppel-like factors 2 and 4, sP-selectin, and sE-selectin in patients with gestational diabetes mellitus.	SELE SELP	3.30e-06	3	37	2	36655409
Pubmed	Evaluation of variants in the selectin genes in age-related macular degeneration.	SELE SELP	3.30e-06	3	37	2	21521525
Pubmed	PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.	SELE SELP	3.30e-06	3	37	2	38243063
Pubmed	IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules.	SELE SELP	3.30e-06	3	37	2	11929781
Pubmed	Hydrocortisone reduced in vivo, inflammation-induced slow rolling of leukocytes and their extravasation into human conjunctiva.	SELE SELP	3.30e-06	3	37	2	12200386
Interaction	SELPLG interactions	SELE SELP BACE1	2.65e-06	16	35	3	int:SELPLG
Cytoband	1q22-q25	SELE SELP	1.90e-06	3	37	2	1q22-q25
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	SELE SELP	4.89e-03	129	37	2	chr1q24
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	OR1Q1 RALGPS1	5.58e-03	138	37	2	chr9q33
GeneFamily	CD molecules\|Selectins\|Sushi domain containing\|C-type lectin domain containing	SELE SELP	5.96e-06	3	26	2	945
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE SELP	1.58e-03	41	26	2	1298
GeneFamily	Solute carriers	SLC6A1 SLC5A7 SLC17A5 SLC5A6	2.29e-03	395	26	4	752
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE SELP	3.02e-03	57	26	2	1179
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEACAM16 SLC5A7 ANO5 CHRM2	1.07e-05	166	37	4	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEACAM16 SLC5A7 ANO5 CHRM2	1.07e-05	166	37	4	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	11.5-Airway-Epithelial-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	SLC5A7 CHRM2 SVOP F12	1.90e-05	192	37	4	a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCell	15-Airway-Epithelial-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	SLC5A7 CHRM2 SVOP F12	2.02e-05	195	37	4	56356a9aeb67b50a74425be2cd9c50d31416c1b3
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SELE SELP HHIPL1	5.35e-05	88	37	3	52d4e572e6800eaa073ef62adaf4e42882ce1eed
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SELE SELP HHIPL1	5.35e-05	88	37	3	eadf8f0fb1181c504942c48d55d309ca4e5f6485
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SELE SELP HHIPL1	5.35e-05	88	37	3	72b789cbccce675f37e0553f63df93643af12b4e
Drug	Biotin	SELE SELP SLC5A6	1.63e-06	15	36	3	ctd:D001710
Drug	NSC295110	SELE SELP	7.28e-06	3	36	2	CID005458605
Drug	Glycopyrrolate [596-51-0]; Down 200; 10uM; MCF7; HT_HG-U133A	FOCAD PAOX CPD FA2H RALGPS1	1.43e-05	198	36	5	3427_DN
Drug	succinyl chloride	SELE SELP	2.42e-05	5	36	2	CID000010970
Drug	GSC-150	SELE SELP	2.42e-05	5	36	2	CID000196962
Drug	LNFPIII	SELE SELP	2.42e-05	5	36	2	CID003586141
Drug	O-Sialic Acid	SELE SELP	2.42e-05	5	36	2	DB03721
Drug	stearyl sulfate	SELE SELP	3.63e-05	6	36	2	CID000008912
Drug	Sri 8835	SELE SELP	3.63e-05	6	36	2	CID000479975
Drug	ONO-4057	SELE SELP	3.63e-05	6	36	2	CID006438358
Drug	sulfur trioxide-trimethylamine	SELE SELP	3.63e-05	6	36	2	CID000222852
Drug	dimethyl(methylthio)sulfonium	SELE SELP	5.08e-05	7	36	2	CID002737115
Drug	SKF 100330A	SLC6A1 CHRM2	5.08e-05	7	36	2	CID000134985
Drug	Val-lys	BACE1 STT3B	6.77e-05	8	36	2	CID000168058
Drug	formalin	SELE SELP ALKBH3 PAOX	7.52e-05	143	36	4	CID000000712
Drug	Le(x	SELE SELP	8.69e-05	9	36	2	CID004571095
Drug	trestatin A	SELE SELP	8.69e-05	9	36	2	CID003054994
Drug	AC1NP3ER	SELE SELP	8.69e-05	9	36	2	CID005123418
Drug	miripirium chloride	SLC5A7 SELP DYM	1.06e-04	58	36	3	CID000017671
Drug	dinitrobenzenesulfonic acid	SELE SELP	1.09e-04	10	36	2	ctd:C007488
Drug	GP515	SELE SELP	1.32e-04	11	36	2	CID000132663
Drug	F-OH	PAOX CPD F12	1.35e-04	63	36	3	CID000123334
Drug	CC-I	SLC6A1 SELE SELP	1.42e-04	64	36	3	CID000448159
Drug	DB04780	SELE SELP FA2H F12	1.47e-04	170	36	4	CID005459389
Drug	talsaclidine	BACE1 CHRM2	1.59e-04	12	36	2	CID000071792
Drug	phenylacetonitrile	PAOX DYM	1.59e-04	12	36	2	CID000008794
Drug	4-F-GlcNAc	SELE SELP	1.59e-04	12	36	2	CID000164285
Drug	Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	BACE1 SLC17A5 MBOAT2 FA2H	1.79e-04	179	36	4	1112_UP
Disease	major depressive disorder (is_marker_for)	SLC5A7 CHRM2	1.84e-04	17	35	2	DOID:1470 (is_marker_for)
Disease	Epilepsy	SLC6A1 CHRM2 SLC5A6	2.94e-04	109	35	3	C0014544
Disease	partial thromboplastin time	SELP F12	3.71e-04	24	35	2	EFO_0004310
Disease	metabolite measurement	PAOX MPV17L2 CPT2 FA2H F12	4.90e-04	560	35	5	EFO_0004725
Disease	L-Selectin measurement	SELE SELP	6.22e-04	31	35	2	EFO_0008202
Disease	Developmental delay (disorder)	SLC5A6 STT3B	8.87e-04	37	35	2	C0424605

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGSLWYTPIRREWYY	BACE1	246	P56817
PLYTRIPWYFLSGAT	ANO5	451	Q75V66
YSWYAGPTLSVSYLV	CEACAM16	51	Q2WEN9
RLTAWYGELPYTYSR	ALKBH3	131	Q96Q83
SMNLYTLYTVIGYWP	CHRM2	76	P08172
TYLKPRLAAFWYYTT	ATP5MGL	21	Q7Z4Y8
IYLTASYTYPFRGWP	ABHD16B	16	Q9H3Z7
LIRFVPSSLSWYGAY	CPT2	191	P23786
TRYWVILSGSTLLYY	RALGPS1	456	Q5JS13
LGWDTYLSYLKYRSP	MPV17L2	176	Q567V2
LSIKPSLTFYSSWYY	MBOAT2	436	Q6ZWT7
LYVYYSVGIRSSEWI	HHIPL1	266	Q96JK4
SILSYSPSYYWIGIR	SELE	61	P16581
VTSSTSYFLPYWLFG	LHFPL1	21	Q86WI0
WVPLVLYLSWSYYRT	FA2H	176	Q7L5A8
VIYSISYSTRPGWFD	CDHR2	276	Q9BYE9
PYVWSLVYNSAVGLY	DYM	641	Q7RTS9
YKTGDYWRLLVPGTY	CPD	826	O75976
KVLPYYSSYYWIGIR	SELP	81	P16109
VVAGYSYWTLAYALR	CERCAM	466	Q5T4B2
YNWTFYTLLTLLPTY	SLC17A5	301	Q9NRA2
PRGQLLSWFYYKSYS	FOCAD	1016	Q5VW36
RWHSAPYTRGSYSYV	PAOX	426	Q6QHF9
FYGTLSWVYFRPLSS	OR1Q1	251	Q15612
PGVYTDVAYYLAWIR	F12	596	P00748
TVYGLWYLSSDLVYI	SLC5A7	401	Q9GZV3
LYYGILSAFAPVYSW	SVOP	161	Q8N4V2
WAIYYLYNSFTTTLP	SLC6A1	146	P30531
PTGLQRFYSLSYLWY	SLC5A6	516	Q9Y289
GRLSRKYIYSLYWST	CNGA3	346	Q16281
LSVIYLTYTGYIAPW	STT3B	366	Q8TCJ2
YSTHLQRWLTYYPSG	NDST2	756	P52849
SVGGYLYWTTLYSVE	ROS1	796	P08922
YALFNLSVTPYTYWG	ROS1	1011	P08922
TWYGITSPTPTYLVY	ROS1	1476	P08922
TYTSTGYPTLFWYVE	TRAV40	41	A0A0B4J280
LYTVAYYFTTGRLLW	XKR5	21	Q6UX68
LLTYGLTWIYYTRCG	SIGLEC14	371	Q08ET2
YPVGYEATRIYWSLR	KMT2D	5206	O14686