Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	GPR89B CLCNKA CLCNKB GPR89A	6.75e-06	17	150	4	GO:0008308
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	GPR89B EEF1AKMT4-ECE2 MGAM DMXL2 ZFYVE16 ABCA13 SEC24A TICAM1 SLC44A2 MPEG1 LAMP2 APOB ASB14 GPR161 WASH6P GBP5 ABCA5 PKD1 SORCS2 GPR89A UNC13C NOSTRIN	1.47e-04	1307	149	22	GO:0030659
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	1.51e-04	3	149	2	GO:0043291
GeneOntologyCellularComponent	vesicle membrane	GPR89B EEF1AKMT4-ECE2 MGAM DMXL2 ZFYVE16 ABCA13 SEC24A TICAM1 SLC44A2 MPEG1 LAMP2 APOB ASB14 GPR161 WASH6P GBP5 ABCA5 PKD1 SORCS2 GPR89A UNC13C NOSTRIN	1.79e-04	1325	149	22	GO:0012506
HumanPheno	Abnormal glomerular filtration rate	CASR CLCNKA CLCNKB PKD1 SLC37A4	1.55e-05	29	58	5	HP:0012212
HumanPheno	Decreased glomerular filtration rate	CASR CLCNKA CLCNKB PKD1 SLC37A4	1.55e-05	29	58	5	HP:0012213
Domain	Rav1p_C	DMXL2 DMXL1	5.82e-05	2	143	2	IPR022033
Domain	Rav1p_C	DMXL2 DMXL1	5.82e-05	2	143	2	PF12234
Domain	Cl_channel-K	CLCNKA CLCNKB	5.82e-05	2	143	2	IPR002250
Domain	ABC_A	ABCA13 ABCA8 ABCA5	9.19e-05	12	143	3	IPR026082
Domain	VWF_A	COL12A1 VWF SEC24A MATN1 ITIH2 ANAPC1	1.13e-04	99	143	6	IPR002035
Domain	-	COL12A1 VWF SEC24A MATN1 ITIH2	2.59e-04	74	143	5	3.40.50.410
Domain	HJURP_C	MEF2A MEF2C	3.46e-04	4	143	2	IPR022102
Domain	MADS_MEF2-like	MEF2A MEF2C	3.46e-04	4	143	2	IPR033896
Domain	PC1	PKD1L3 PKD1	3.46e-04	4	143	2	IPR000434
Domain	HJURP_C	MEF2A MEF2C	3.46e-04	4	143	2	PF12347
Domain	MADS_BOX_1	MEF2A MEF2C	8.56e-04	6	143	2	PS00350
Domain	MADS	MEF2A MEF2C	8.56e-04	6	143	2	SM00432
Domain	Hydantoinase/dihydroPyrase	DPYSL3 CRMP1	8.56e-04	6	143	2	IPR011778
Domain	SRF-TF	MEF2A MEF2C	8.56e-04	6	143	2	PF00319
Domain	MADS_BOX_2	MEF2A MEF2C	8.56e-04	6	143	2	PS50066
Domain	VWA	COL12A1 VWF MATN1 ITIH2	8.89e-04	56	143	4	PF00092
Domain	TIR_dom	TICAM1 TLR5 IL17RD	8.93e-04	25	143	3	IPR000157
Domain	PKD	PKD1 SORCS2	1.19e-03	7	143	2	PF00801
Domain	TF_MADSbox	MEF2A MEF2C	1.19e-03	7	143	2	IPR002100
Domain	-	DPYSL3 CRMP1	1.58e-03	8	143	2	2.30.40.10
Domain	LAMININ_IVA	LAMA3 LAMC1	1.58e-03	8	143	2	PS51115
Domain	Laminin_B	LAMA3 LAMC1	1.58e-03	8	143	2	PF00052
Domain	LamB	LAMA3 LAMC1	1.58e-03	8	143	2	SM00281
Domain	Laminin_IV	LAMA3 LAMC1	1.58e-03	8	143	2	IPR000034
Domain	Cl-channel_core	CLCNKA CLCNKB	2.02e-03	9	143	2	IPR014743
Domain	-	CLCNKA CLCNKB	2.02e-03	9	143	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	2.02e-03	9	143	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	2.02e-03	9	143	2	IPR001807
Domain	PKD/Chitinase_dom	PKD1 SORCS2	2.02e-03	9	143	2	IPR022409
Domain	PKD	PKD1 SORCS2	2.02e-03	9	143	2	SM00089
Domain	P-loop_NTPase	SPAST KIF27 ABCA13 NOA1 MSH2 FANCM ABCA8 NLRC4 RRAGC EEF2 GBP4 GBP5 ABCA5 HFM1 KIF5B	2.17e-03	848	143	15	IPR027417
Domain	LRR_TYP	LRWD1 IGSF10 TLR5 LRRTM2 PKD1 SLITRK6	2.44e-03	177	143	6	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRWD1 IGSF10 TLR5 LRRTM2 PKD1 SLITRK6	2.44e-03	177	143	6	IPR003591
Domain	Amidohydro_1	DPYSL3 CRMP1	2.52e-03	10	143	2	PF01979
Domain	GBP_C	GBP4 GBP5	2.52e-03	10	143	2	PF02841
Domain	Metal-dep_hydrolase_composite	DPYSL3 CRMP1	2.52e-03	10	143	2	IPR011059
Domain	-	RGPD1 GOLGA4	2.52e-03	10	143	2	1.10.220.60
Domain	Grip	RGPD1 GOLGA4	3.06e-03	11	143	2	SM00755
Domain	G_GB1_RHD3_dom	GBP4 GBP5	3.06e-03	11	143	2	IPR030386
Domain	GRIP	RGPD1 GOLGA4	3.06e-03	11	143	2	PF01465
Domain	Guanylate-bd_N	GBP4 GBP5	3.06e-03	11	143	2	IPR015894
Domain	PKD	PKD1 SORCS2	3.06e-03	11	143	2	PS50093
Domain	PKD_dom	PKD1 SORCS2	3.06e-03	11	143	2	IPR000601
Domain	PKD_channel	PKD1L3 PKD1	3.06e-03	11	143	2	PF08016
Domain	Guanylate-bd_C	GBP4 GBP5	3.06e-03	11	143	2	IPR003191
Domain	GBP	GBP4 GBP5	3.06e-03	11	143	2	PF02263
Domain	Amidohydro-rel	DPYSL3 CRMP1	3.06e-03	11	143	2	IPR006680
Domain	PKD1_2_channel	PKD1L3 PKD1	3.06e-03	11	143	2	IPR013122
Domain	-	PKD1 SORCS2	3.06e-03	11	143	2	2.60.40.670
Domain	G_GB1_RHD3	GBP4 GBP5	3.06e-03	11	143	2	PS51715
Domain	TPR	TTC28 RGPD1 TTC27 TEX11 CDC27	3.16e-03	129	143	5	SM00028
Domain	TPR_repeat	TTC28 RGPD1 TTC27 TEX11 CDC27	3.60e-03	133	143	5	IPR019734
Domain	VWFA	COL12A1 VWF MATN1 ITIH2	3.63e-03	82	143	4	PS50234
Domain	GRIP_dom	RGPD1 GOLGA4	3.65e-03	12	143	2	IPR000237
Domain	GRIP	RGPD1 GOLGA4	3.65e-03	12	143	2	PS50913
Domain	VWA	COL12A1 VWF MATN1 ITIH2	3.96e-03	84	143	4	SM00327
Domain	-	SPAST ABCA13 NOA1 MSH2 FANCM ABCA8 NLRC4 RRAGC EEF2 GBP4 GBP5 ABCA5 HFM1	4.84e-03	746	143	13	3.40.50.300
Domain	Cys-rich_flank_reg_C	IGSF10 TLR5 PKD1 SLITRK6	5.06e-03	90	143	4	IPR000483
Domain	LRRCT	IGSF10 TLR5 PKD1 SLITRK6	5.06e-03	90	143	4	SM00082
Domain	ABC_tran	ABCA13 ABCA8 ABCA5	5.91e-03	48	143	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA13 ABCA8 ABCA5	5.91e-03	48	143	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA13 ABCA8 ABCA5	6.26e-03	49	143	3	PS00211
Domain	CBS	CLCNKA CLCNKB	6.51e-03	16	143	2	SM00116
Domain	GRAM	TBC1D9 GRAMD2A	6.51e-03	16	143	2	SM00568
Domain	Laminin_N	LAMA3 LAMC1	6.51e-03	16	143	2	IPR008211
Domain	LamNT	LAMA3 LAMC1	6.51e-03	16	143	2	SM00136
Domain	LAMININ_NTER	LAMA3 LAMC1	6.51e-03	16	143	2	PS51117
Domain	Laminin_N	LAMA3 LAMC1	6.51e-03	16	143	2	PF00055
Domain	ABC_transporter-like	ABCA13 ABCA8 ABCA5	6.62e-03	50	143	3	IPR003439
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	HEXB PIGN GPR89B DPYSL3 COL12A1 LEMD2 LAMC1 LAMP2 LBR DMXL1 IGSF10 EEF2 NEGR1 FANCI LTN1 ADAM17 KIF5B TRIM13 SLC37A4 PLXNA1	2.85e-07	1201	151	20	35696571
Pubmed	Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis.	VWF MEF2A MEF2C	3.20e-07	4	151	3	8817457
Pubmed	Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.	FANCM BRCA2 FANCI	3.20e-07	4	151	3	19737859
Pubmed	Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.	VWF ITGA8 LAMC1 MEF2C	3.30e-07	14	151	4	36347239
Pubmed	Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.	MYF5 MEF2A MEF2C	2.77e-06	7	151	3	8026334
Pubmed	Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.	MYF5 MEF2A MEF2C	2.77e-06	7	151	3	9418854
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	TBXAS1 VWF BCHE APOB F8 ITIH2 GOLGA4	8.28e-06	165	151	7	14718574
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DMXL2 ZFYVE16 VPS8 LBR DMXL1 RRAGC GPR89A ADAM17 TRIM13 PLXNA1 GOLGA4	1.38e-05	504	151	11	34432599
Pubmed	Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.	NLRC4 GBP4 GBP5	1.72e-05	12	151	3	35906252
Pubmed	Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.	MYF5 MEF2A MEF2C	1.72e-05	12	151	3	16424906
Pubmed	Intracellular interaction of von Willebrand factor and factor VIII depends on cellular context: lessons from platelet-expressed factor VIII.	VWF F8	1.87e-05	2	151	2	15731176
Pubmed	Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.	MEF2A MEF2C	1.87e-05	2	151	2	16469744
Pubmed	Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.	MEF2A MEF2C	1.87e-05	2	151	2	25336633
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	1.87e-05	2	151	2	27335120
Pubmed	A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.	VWF F8	1.87e-05	2	151	2	38320121
Pubmed	Rise of levels of von Willebrand factor and factor VIII with age: Role of genetic and acquired risk factors.	VWF F8	1.87e-05	2	151	2	33221577
Pubmed	Mechano-covalent protection of coagulation factor VIII by von Willebrand factor.	VWF F8	1.87e-05	2	151	2	36240294
Pubmed	Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study.	VWF F8	1.87e-05	2	151	2	19110358
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	1.87e-05	2	151	2	8812470
Pubmed	Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project.	VWF F8	1.87e-05	2	151	2	23690449
Pubmed	Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates.	VWF SLC44A2	1.87e-05	2	151	2	33556175
Pubmed	Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study.	VWF F8	1.87e-05	2	151	2	22219226
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	1.87e-05	2	151	2	25919862
Pubmed	von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.	VWF F8	1.87e-05	2	151	2	26635035
Pubmed	The role of VWF in the immunogenicity of FVIII.	VWF F8	1.87e-05	2	151	2	18549909
Pubmed	The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor.	VWF F8	1.87e-05	2	151	2	9218428
Pubmed	The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor.	VWF F8	1.87e-05	2	151	2	7756647
Pubmed	Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort.	VWF F8	1.87e-05	2	151	2	18535282
Pubmed	Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.	VWF F8	1.87e-05	2	151	2	20624989
Pubmed	Association of the factor VIII light chain with von Willebrand factor.	VWF F8	1.87e-05	2	151	2	3134349
Pubmed	The influence of von Willebrand factor on factor VIII activity measurements.	VWF F8	1.87e-05	2	151	2	18983499
Pubmed	Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium.	VWF F8	1.87e-05	2	151	2	14517489
Pubmed	Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities.	VWF F8	1.87e-05	2	151	2	15471879
Pubmed	The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor.	VWF F8	1.87e-05	2	151	2	8562925
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	1.87e-05	2	151	2	38069401
Pubmed	GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.	GPR89B GPR89A	1.87e-05	2	151	2	22572823
Pubmed	Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.	NLRC4 TLR5	1.87e-05	2	151	2	16648852
Pubmed	Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.	MEF2A XIRP2	1.87e-05	2	151	2	20093629
Pubmed	Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins.	MEF2A MEF2C	1.87e-05	2	151	2	21741404
Pubmed	von Willebrand factor variant p.Arg924Gln marks an allele associated with reduced von Willebrand factor and factor VIII levels.	VWF F8	1.87e-05	2	151	2	20492463
Pubmed	Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.	MEF2A XIRP2	1.87e-05	2	151	2	17046827
Pubmed	Solution structure of the major factor VIII binding region on von Willebrand factor.	VWF F8	1.87e-05	2	151	2	24700780
Pubmed	Human exonuclease I interacts with the mismatch repair protein hMSH2.	MSH2 EXO1	1.87e-05	2	151	2	9788596
Pubmed	Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies.	VWF F8	1.87e-05	2	151	2	21940821
Pubmed	Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings.	VWF F8	1.87e-05	2	151	2	26473492
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	1.87e-05	2	151	2	20805576
Pubmed	Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment.	VWF F8	1.87e-05	2	151	2	20194895
Pubmed	VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease.	VWF F8	1.87e-05	2	151	2	23349392
Pubmed	NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.	NLRC4 TLR5	1.87e-05	2	151	2	25232720
Pubmed	Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma.	MEF2A MEF2C	1.87e-05	2	151	2	17611778
Pubmed	Interaction between VWF and FVIII in treating VWD.	VWF F8	1.87e-05	2	151	2	25605439
Pubmed	Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms.	ASXL1 JAK2	1.87e-05	2	151	2	38340948
Pubmed	von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model.	VWF F8	1.87e-05	2	151	2	37756521
Pubmed	GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.	GPR89B GPR89A	1.87e-05	2	151	2	18794847
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	1.87e-05	2	151	2	15044642
Pubmed	ASXL1 and JAK2V617F gene mutation screening in Iranian patients with chronic myeloid leukemia.	ASXL1 JAK2	1.87e-05	2	151	2	27640403
Pubmed	Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies.	VWF F8	1.87e-05	2	151	2	17958741
Pubmed	Von Willebrand factor processing.	VWF F8	1.87e-05	2	151	2	28139814
Pubmed	Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa.	NLRC4 TLR5	1.87e-05	2	151	2	27855208
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	1.87e-05	2	151	2	8041726
Pubmed	Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis.	VWF F8	1.87e-05	2	151	2	32032127
Pubmed	Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor.	VWF F8	1.87e-05	2	151	2	12958606
Pubmed	ASXL1 mutation confers poor prognosis in primary myelofibrosis patients with low JAK2V617F allele burden but not in those with high allele burden.	ASXL1 JAK2	1.87e-05	2	151	2	33046688
Pubmed	Factor VIII antibody immune complexes modulate the humoral response to factor VIII in an epitope-dependent manner.	VWF F8	1.87e-05	2	151	2	37720212
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	1.87e-05	2	151	2	18648499
Pubmed	Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIII.	VWF F8	1.87e-05	2	151	2	23168412
Pubmed	Physiological Roles of the von Willebrand Factor-Factor VIII Interaction.	VWF F8	1.87e-05	2	151	2	32189311
Pubmed	The dermal-epidermal junction of human skin contains a novel laminin variant.	LAMA3 LAMC1	1.87e-05	2	151	2	1383241
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	1.87e-05	2	151	2	8544406
Pubmed	CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.	DPYSL3 CRMP1	1.87e-05	2	151	2	27836492
Pubmed	Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.	NLRC4 TLR5	1.87e-05	2	151	2	27546231
Pubmed	Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia.	JAK2 GOLGA4	1.87e-05	2	151	2	34697799
Pubmed	Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor.	VWF F8	1.87e-05	2	151	2	32544272
Pubmed	Axonal morphogenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization.	DPYSL3 CRMP1	1.87e-05	2	151	2	12814366
Pubmed	Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa.	NLRC4 TLR5	1.87e-05	2	151	2	25402425
Pubmed	Von Willebrand factor accelerates platelet adhesion and thrombus formation on a collagen surface in platelet-reduced blood under flow conditions.	VWF F8	1.87e-05	2	151	2	15459008
Pubmed	A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models.	VWF F8	1.87e-05	2	151	2	23335368
Pubmed	High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor.	VWF F8	1.87e-05	2	151	2	30471183
Pubmed	TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin.	NLRC4 TLR5	1.87e-05	2	151	2	21072873
Pubmed	Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding.	VWF F8	1.87e-05	2	151	2	12719775
Pubmed	The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.	VWF F8	1.87e-05	2	151	2	30642920
Pubmed	Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.	VWF F8	1.87e-05	2	151	2	16823491
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	1.87e-05	2	151	2	24863058
Pubmed	The D' domain of von Willebrand factor requires the presence of the D3 domain for optimal factor VIII binding.	VWF F8	1.87e-05	2	151	2	30111575
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	1.87e-05	2	151	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	1.87e-05	2	151	2	9916791
Pubmed	Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.	ATG7 LAMP2	1.87e-05	2	151	2	33891876
Pubmed	Heterogeneity and reciprocity of FVIII and VWF expression, and the response to shear stress in cultured human endothelial cells.	VWF F8	1.87e-05	2	151	2	35950488
Pubmed	Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin.	NLRC4 TLR5	1.87e-05	2	151	2	25914934
Pubmed	Coagulation factor VIII regulates von Willebrand factor homeostasis invivo.	VWF F8	1.87e-05	2	151	2	37726033
Pubmed	A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.	VWF F8	1.87e-05	2	151	2	22855607
Pubmed	Sources of variation in factor VIII, von Willebrand factor and fibrinogen measurements: implications for detecting deficiencies and increased plasma levels.	VWF F8	1.87e-05	2	151	2	20627205
Pubmed	Evaluation of von Willebrand factor phenotypes and genotypes in Hemophilia A patients with and without identified F8 mutations.	VWF F8	1.87e-05	2	151	2	25780857
Pubmed	Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.	VWF F8	1.87e-05	2	151	2	25779970
Pubmed	Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.	VWF F8	1.87e-05	2	151	2	27749002
Pubmed	von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins.	VWF F8	1.87e-05	2	151	2	17119108
Pubmed	Correlation between von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity and factor VIII activity in plasma.	VWF F8	1.87e-05	2	151	2	17786534
Pubmed	Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice.	VWF F8	1.87e-05	2	151	2	28581694
Pubmed	ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms.	ASXL1 JAK2	1.87e-05	2	151	2	36005555
Pubmed	Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.	JAK2 PKD1	1.87e-05	2	151	2	30872773
Cytoband	1p22.2	GBP4 GBP5 HFM1	1.08e-04	28	151	3	1p22.2
GeneFamily	ATP binding cassette subfamily A	ABCA13 ABCA8 ABCA5	7.19e-05	14	108	3	805
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2A MEF2C	2.10e-04	4	108	2	649
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCM BRCA2 FANCI	2.19e-04	20	108	3	548
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2A MEF2C	3.49e-04	5	108	2	1086
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	1.54e-03	10	108	2	302
GeneFamily	X-linked mental retardation\|RNA helicases	FANCM HFM1	1.88e-03	11	108	2	1168
GeneFamily	Laminin subunits	LAMA3 LAMC1	2.24e-03	12	108	2	626
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	TBC1D9 GRAMD2A	2.64e-03	13	108	2	1146
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC1 CDC27	3.07e-03	14	108	2	402
GeneFamily	Olfactory receptors, family 8	OR8H2 OR8H3 OR8D1	3.13e-03	49	108	3	155
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	TICAM1 IL17RD	3.53e-03	15	108	2	1296
GeneFamily	Aminopeptidases\|CD molecules	LVRN XPNPEP2	4.53e-03	17	108	2	104
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC28 RGPD1 TTC27 CDC27	5.01e-03	115	108	4	769
GeneFamily	Lipases\|Arylacetamide deacetylase family	DAGLB LIPF	7.55e-03	22	108	2	464
CoexpressionAtlas	B cells, B1a.PC, IgD+ IgM+ CD19+ CD43+ CD5+ CD45R+, Peritoneal Cavity, avg-3	DMXL2 MPEG1 LAMC1 PKD1L3 MEF2C NLRC4 TBC1D9 GRAMD2A GBP4 SORCS2 KYNU	1.22e-05	325	142	11	GSM538222_500
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM COL12A1 ABCA13 PCLO APOB TEX11 XIRP2 UNC13C ATP1A4 UNC79 ANO3	3.87e-11	184	151	11	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM COL12A1 ABCA13 PCLO APOB TEX11 XIRP2 UNC13C ATP1A4 UNC79 ANO3	3.87e-11	184	151	11	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM COL12A1 ABCA13 PCLO APOB TEX11 XIRP2 UNC13C ATP1A4 UNC79 ANO3	3.87e-11	184	151	11	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO TBC1D9 NEGR1 UNC13C UNC79 ANO3 CDH12 CNR1	1.92e-07	180	151	8	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 SLC44A2 LAMA3 MEF2A F8 MEF2C HSD3B1 NOSTRIN	3.53e-07	195	151	8	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C GBP4 DCHS1 NOSTRIN	4.11e-07	199	151	8	8b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCell	facs-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 MEF2C TBC1D9 GRAMD2A NOSTRIN KYNU TCTN1	1.75e-06	168	151	7	d2afc097ae1243574210be6a751685f949ea941a
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 MEF2C TBC1D9 GRAMD2A NOSTRIN KYNU TCTN1	1.75e-06	168	151	7	d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 MEF2C TBC1D9 GRAMD2A NOSTRIN KYNU TCTN1	1.75e-06	168	151	7	c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXAS1 DMXL2 RADX MPEG1 TBC1D9 RRAGC KYNU	2.39e-06	176	151	7	270d7908dbd84028958d257f94941dc685e20255
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C DCHS1 NOSTRIN	2.67e-06	179	151	7	8f9e538c822940785130297712b75131812a4603
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 MEF2A F8 MEF2C IGSF10 GBP4 GVINP1	2.77e-06	180	151	7	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 MEF2A F8 MEF2C IGSF10 GBP4 GVINP1	2.77e-06	180	151	7	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	COL12A1 PCLO LMTK2 LAMA3 ABCA8 GRAMD2A THNSL2	3.09e-06	183	151	7	6821dca076318115d360ff426eb1218cfe104063
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D9 NEGR1 UNC13C UNC79 ANO3 CDH12 CNR1	3.57e-06	187	151	7	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	COVID-19-kidney-Glomerular_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE2A SLC44A2 ITGA8 SHROOM2 F8 MEF2C NOSTRIN	4.54e-06	194	151	7	660535b492445063d965095a50e1e299ce04c50a
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HEXB TBXAS1 DMXL2 ATG7 ZFYVE16 ADAM17 KYNU	4.70e-06	195	151	7	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SFTA2 COL12A1 LAMA3 GRAMD2A SPRING1 PLXNA1 SCAI	4.70e-06	195	151	7	2a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LVRN COL12A1 LAMC1 ATP8B2 ABCA8 IGSF10 NEGR1	4.70e-06	195	151	7	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SFTA2 COL12A1 LAMA3 GRAMD2A SPRING1 PLXNA1 SCAI	4.70e-06	195	151	7	68f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCLO MEF2C ABCA5 NEGR1 PKD1 UNC79 SCAI	4.86e-06	196	151	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE2A VWF STARD8 GBP4 HFM1 NOSTRIN CNR1	5.02e-06	197	151	7	a78111171819db746af7b162c77f9a324453f3ce
ToppCell	distal-Endothelial-Bronchial_Vessel_1-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PDE2A VWF LAMC1 MEF2C XIRP2 NOSTRIN IL17RD	5.19e-06	198	151	7	5bdffabf80716dd80c1265c3d126c7a25340251c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 PCLO MEF2C ABCA5 NEGR1 PKD1 UNC79	5.19e-06	198	151	7	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C GBP4 NOSTRIN	5.19e-06	198	151	7	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 PCLO MEF2C NEGR1 UNC79 CDH12 SCAI	5.19e-06	198	151	7	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Kidney-Endothelial\|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.	PDE2A VWF F8 MEF2C GBP4 DCHS1 NOSTRIN	5.37e-06	199	151	7	b543f0686522df43737e9ffa5c9733e42b8a9f4d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	DPYSL3 HIVEP2 SPAST TTC28 PCLO MEF2C CRMP1	5.55e-06	200	151	7	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF F8 MEF2C GBP4 DCHS1 NOSTRIN	5.55e-06	200	151	7	b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PCLO MEF2C ABCA5 NEGR1 PKD1 UNC79 SCAI	5.55e-06	200	151	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF F8 MEF2C GBP4 DCHS1 NOSTRIN	5.55e-06	200	151	7	dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF F8 MEF2C GBP4 DCHS1 NOSTRIN	5.55e-06	200	151	7	ced14d83222dbebca85c40540e76824e683354f3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF F8 MEF2C GBP4 DCHS1 NOSTRIN	5.55e-06	200	151	7	7a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIVEP2 RGPD1 ATP8B2 RESF1 GBP5 CCR7	1.39e-05	153	151	6	7480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIVEP2 RGPD1 ATP8B2 RESF1 GBP5 CCR7	1.55e-05	156	151	6	53ded973358e3e48054130131e959f0d1f4ef60f
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VWF LAMA3 GBP4 GVINP1 CLCNKB	1.63e-05	93	151	5	312291db0fab96952017f9faf2057c28f3719556
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VWF LAMA3 GBP4 GVINP1 CLCNKB	1.63e-05	93	151	5	4eca07c288fe15531a685522c61746671c1c87fb
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VWF LAMA3 GBP4 GVINP1 CLCNKB	1.63e-05	93	151	5	8f65381291fc92b56bf0fc2caac013a54560737b
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A ITGA8 XPNPEP2 ABCA8 IGSF10 NEGR1	1.79e-05	160	151	6	8a41e2c96e0e170ac35daf6c403bf961b8d7c30b
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A ITGA8 XPNPEP2 ABCA8 IGSF10 NEGR1	1.79e-05	160	151	6	c8dc575562b463fd30832d322c28006f18f7ab9c
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	1.79e-05	160	151	6	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	TCGA-Bladder-Solid_Tissue_Normal\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A ITGA8 XPNPEP2 ABCA8 IGSF10 NEGR1	1.79e-05	160	151	6	d6678996e12eaf2b735f1dfae32418cb2fabf268
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EEF1AKMT4-ECE2 COL12A1 ABCA8 GPR161 NEGR1 ANO3	1.99e-05	163	151	6	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EEF1AKMT4-ECE2 COL12A1 ABCA8 GPR161 NEGR1 ANO3	1.99e-05	163	151	6	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	GBP4 GBP5 XIRP2 LRRTM2 CFAP74 ANO3	2.06e-05	164	151	6	362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 ABCA13 MPEG1 NEGR1 KYNU TCTN1	2.21e-05	166	151	6	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYF5 ABCA13 MPEG1 NEGR1 KYNU TCTN1	2.21e-05	166	151	6	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 RADX MPEG1 TBC1D9 UNC13C KYNU	2.36e-05	168	151	6	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF MEF2C GVINP1 DCHS1 NOSTRIN	2.36e-05	168	151	6	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL12A1 XPNPEP2 ITIH2 FANCI KYNU	2.55e-05	102	151	5	0bbc6344d0baee47326a16a89773bb5c68a7b040
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	COL12A1 XPNPEP2 ITIH2 FANCI KYNU	2.55e-05	102	151	5	11fbdb428824023603e9d4ee41e957ba84e7c29e
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LVRN COL12A1 LAMC1 ATP8B2 ABCA8 ADH4	2.69e-05	172	151	6	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB TBXAS1 STARD8 MPEG1 MEF2C GBP5	2.69e-05	172	151	6	c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	SFTA2 COL12A1 LAMA3 ABCA8 SPRING1 PLXNA1	2.78e-05	173	151	6	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 TTC27 ABCA8 NEGR1 ATP1A4 CNR1	2.78e-05	173	151	6	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAGLB HEXB TBXAS1 MPEG1 MEF2C NLRC4	2.97e-05	175	151	6	53e6f1f8dd482dfa2539e068dacefbb6e08443bc
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF SHROOM2 TLR5 SORCS2 HFM1 IL17RD	3.06e-05	176	151	6	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXAS1 DMXL2 LIPF MPEG1 TBC1D9 RRAGC	3.06e-05	176	151	6	b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF SHROOM2 TLR5 SORCS2 HFM1 IL17RD	3.06e-05	176	151	6	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB TBXAS1 STARD8 MATN1 MEF2C NLRC4	3.37e-05	179	151	6	fae869fb0a91428481bf8a9c111dcc639e2b4278
ToppCell	AT1_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL12A1 LAMA3 ABCA8 GRAMD2A PLXNA1 SCAI	3.37e-05	179	151	6	1603117b52623663458a977c94bf7f9f6c1114b8
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAGLB HEXB TBXAS1 MPEG1 MEF2C NLRC4	3.48e-05	180	151	6	a600bc705993d3a010550a25d3b54358946f061f
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYSL3 PDE2A TTC28 ITGA8 F8 JAK2	3.58e-05	181	151	6	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 DMXL2 RADX LIPF MPEG1 TBC1D9	3.70e-05	182	151	6	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL12A1 VWF LAMC1 F8 ABCA8 NEGR1	3.70e-05	182	151	6	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	DPYSL3 ZFYVE16 MLYCD ARMH3 KYNU SCAI	3.81e-05	183	151	6	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	VWF ITGA8 F8 MEF2C GBP4 NOSTRIN	3.81e-05	183	151	6	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPYSL3 COL12A1 TEX11 SORCS2 HFM1 MACROH2A2	3.81e-05	183	151	6	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF MSH2 FANCI EXO1 NOSTRIN	3.93e-05	184	151	6	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 DMXL2 RADX LIPF MPEG1 TBC1D9	4.05e-05	185	151	6	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 DMXL2 RADX LIPF MPEG1 TBC1D9	4.05e-05	185	151	6	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 LAMC1 TIPARP SERPINB5 GBP5 USP47	4.05e-05	185	151	6	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D9 CRMP1 NEGR1 UNC79 CDH12 CNR1	4.17e-05	186	151	6	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CASR TBC1D9 CLCNKA CLCNKB ABCA5 UNC13C	4.43e-05	188	151	6	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 COL12A1 ITGA8 ABCA8 NEGR1 ANO3	4.84e-05	191	151	6	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DPYSL3 ITGA8 LAMC1 ABCA8 NEGR1 ANO3	4.84e-05	191	151	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DPYSL3 PDE2A VWF CASR F8 DCHS1	4.84e-05	191	151	6	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL12A1 LAMA3 ABCA8 GRAMD2A SPRING1 SCAI	4.84e-05	191	151	6	a15e34ad7dbf3f2f13d5e23ce3ffb6d08fd1f9f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 COL12A1 ITGA8 ABCA8 NEGR1 ANO3	4.84e-05	191	151	6	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 ABCA13 PCLO CASR CLCNKA CLCNKB	4.98e-05	192	151	6	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM COL12A1 ITGA8 SHROOM2 CLCNKA UNC13C	4.98e-05	192	151	6	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DPYSL3 BCHE ABCA8 IGSF10 NEGR1 IL17RD	4.98e-05	192	151	6	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE2A TTC28 MEF2A F8 MEF2C NOSTRIN	4.98e-05	192	151	6	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DPYSL3 ITGA8 LAMC1 ABCA8 NEGR1 ANO3	4.98e-05	192	151	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	COL12A1 VWF TTC28 LAMC1 ABCA8 NEGR1	4.98e-05	192	151	6	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 ABCA13 PCLO CASR CLCNKA CLCNKB	4.98e-05	192	151	6	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 COL12A1 ABCA8 ADH4 NEGR1 ATP1A4	5.12e-05	193	151	6	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 COL12A1 ABCA8 ADH4 NEGR1 ATP1A4	5.12e-05	193	151	6	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	COL12A1 ITGA8 LAMC1 BCHE MEF2C SLITRK6	5.12e-05	193	151	6	e1de67ddada87229f5db0ec193a6da8745a86a64
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	COL12A1 ITGA8 LAMC1 BCHE MEF2C SLITRK6	5.12e-05	193	151	6	b6f5a85210e60798205eaf5884cdb540f549d08a
ToppCell	Monocytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	DMXL2 MPEG1 MEF2C GBP4 GBP5 KYNU	5.27e-05	194	151	6	fa6a2794baa6be6298f415330ff51b26a5402571
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	5.27e-05	194	151	6	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	5.27e-05	194	151	6	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	5.27e-05	194	151	6	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MPEG1 MEF2A MEF2C TBC1D9 CCR7 KYNU	5.27e-05	194	151	6	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	5.27e-05	194	151	6	e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell	ASK440-Endothelial-Endothelium\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	DPYSL3 VWF F8 GBP4 DCHS1 NOSTRIN	5.43e-05	195	151	6	304f0dc91bb57e98b0ca31d6bfb3ff9364e4da56
ToppCell	normal_Lung-Epithelial_cells-AT1\|normal_Lung / Location, Cell class and cell subclass	SFTA2 COL12A1 LAMA3 GRAMD2A PLXNA1 SCAI	5.43e-05	195	151	6	569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	ITGA8 LAMC1 ABCA8 IGSF10 NEGR1 ANO3	5.43e-05	195	151	6	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PDE2A VWF ITGA8 F8 MEF2C NOSTRIN	5.43e-05	195	151	6	a436483fec137584611f86b7a498a4dc2aa19cd3
Disease	Bartter disease type 4B	CLCNKA CLCNKB	2.47e-05	2	147	2	cv:C4310805
Disease	von Willebrand's disease 2 (is_marker_for)	VWF F8	2.47e-05	2	147	2	DOID:0060574 (is_marker_for)
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:0110144 (implicated_via_orthology)
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	2.47e-05	2	147	2	613090
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	2.47e-05	2	147	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	2.47e-05	2	147	2	C4310805
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:0110146 (is_implicated_in)
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	2.47e-05	2	147	2	DOID:445 (implicated_via_orthology)
Disease	Prostatic Neoplasms	TBXAS1 LMTK2 LAMC1 NIPAL3 JAK2 BRCA2 TLR5 HSD3B1 CDC27 IL17RD CDH12 GOLGA4	6.39e-05	616	147	12	C0033578
Disease	Malignant neoplasm of prostate	TBXAS1 LMTK2 LAMC1 NIPAL3 JAK2 BRCA2 TLR5 HSD3B1 CDC27 IL17RD CDH12 GOLGA4	6.39e-05	616	147	12	C0376358
Disease	Bone marrow hypocellularity	FANCM BRCA2 FANCI	9.36e-05	18	147	3	C1855710
Disease	Liver Cirrhosis, Experimental	COL12A1 VWF ZFYVE16 SLC44A2 XPNPEP2 TBC1D9 ADH4 JAK2 GBP4 ADAM17 SLC37A4 KYNU CNR1	1.40e-04	774	147	13	C0023893
Disease	myeloproliferative neoplasm (implicated_via_orthology)	ASXL1 JAK2	1.47e-04	4	147	2	DOID:2226 (implicated_via_orthology)
Disease	Muscle Spasticity	SPAST CNR1	2.44e-04	5	147	2	C0026838
Disease	Fanconi Anemia	FANCM BRCA2 FANCI	2.57e-04	25	147	3	C0015625
Disease	Pancytopenia	FANCM BRCA2 FANCI	2.90e-04	26	147	3	C0030312
Disease	Malignant neoplasm of breast	TBXAS1 PDE2A VWF STARD8 SPAST NOA1 TICAM1 BCHE SHROOM2 EEF2 SERPINB5 BRCA2 EXO1 CDC27 ZNF281	3.17e-04	1074	147	15	C0006142
Disease	Grand Mal Status Epilepticus	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0311335
Disease	Status Epilepticus, Subclinical	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0751522
Disease	Simple Partial Status Epilepticus	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0751524
Disease	Non-Convulsive Status Epilepticus	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0751523
Disease	MYELODYSPLASTIC SYNDROME	ASXL1 FANCM BRCA2 FANCI	3.55e-04	67	147	4	C3463824
Disease	Petit mal status	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0270823
Disease	Complex Partial Status Epilepticus	LAMP2 MEF2C CCR7 CNR1	3.55e-04	67	147	4	C0393734
Disease	essential thrombocythemia (is_implicated_in)	VWF JAK2	3.65e-04	6	147	2	DOID:2224 (is_implicated_in)
Disease	MEDULLOBLASTOMA	GPR161 BRCA2	3.65e-04	6	147	2	155255
Disease	Bartter syndrome	CLCNKA CLCNKB	3.65e-04	6	147	2	cv:C0004775
Disease	familial combined hyperlipidemia (is_marker_for)	VWF APOB	3.65e-04	6	147	2	DOID:13809 (is_marker_for)
Disease	Adult only	MSH2 BRCA2	3.65e-04	6	147	2	C3842001
Disease	Medulloblastoma	GPR161 BRCA2	3.65e-04	6	147	2	cv:C0025149
Disease	Status Epilepticus	LAMP2 MEF2C CCR7 CNR1	3.76e-04	68	147	4	C0038220
Disease	Miller Dieker syndrome	FANCM BRCA2 FANCI	4.03e-04	29	147	3	C0265219
Disease	platelet-to-lymphocyte ratio	VWF TTC28 LEMD2 MEF2C JAK2 CCR7 NOSTRIN ARMH3	4.91e-04	363	147	8	EFO_0008446
Disease	Colorectal Neoplasms	STARD8 ABCA13 MSH2 ABCA8 SERPINB5 ABCA5 EXO1	4.96e-04	277	147	7	C0009404
Disease	LDL cholesterol change measurement	APOB PKD1L3	5.09e-04	7	147	2	EFO_0007804
Disease	intellectual disability (implicated_via_orthology)	HIVEP2 ITGA8 MEF2A MEF2C	5.46e-04	75	147	4	DOID:1059 (implicated_via_orthology)
Disease	ovarian neoplasm	ATG7 ITGA8 MSH2 TIPARP BRCA2	5.71e-04	134	147	5	C0919267
Disease	interleukin 18 measurement	SPAST TTC27 NLRC4 NOSTRIN	5.74e-04	76	147	4	EFO_0004581
Disease	Abnormality of radial ray	FANCM BRCA2 FANCI	5.92e-04	33	147	3	C4228778
Disease	mean platelet volume	DAGLB HIVEP2 VWF STARD8 TTC28 PCDHGA9 CASR MEF2C ADH4 JAK2 MORF4L2 KYNU FBXO34 NIN	5.99e-04	1020	147	14	EFO_0004584
Disease	Malignant neoplasm of ovary	ATG7 ITGA8 MSH2 TIPARP BRCA2	6.32e-04	137	147	5	C1140680
Disease	myelofibrosis (is_implicated_in)	ASXL1 JAK2	6.77e-04	8	147	2	DOID:4971 (is_implicated_in)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF ITGA8	6.77e-04	8	147	2	DOID:4783 (biomarker_via_orthology)
Disease	Glioma	GPR161 BRCA2	8.67e-04	9	147	2	cv:C0017638
Disease	venous thromboembolism, factor VII measurement	VWF SLC44A2 ADH4	8.99e-04	38	147	3	EFO_0004286, EFO_0004619
Disease	medulloblastoma (is_implicated_in)	GPR161 BRCA2	1.08e-03	10	147	2	DOID:0050902 (is_implicated_in)
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	1.08e-03	10	147	2	DOID:12387 (implicated_via_orthology)
Disease	thrombosis (implicated_via_orthology)	TBXAS1 JAK2	1.08e-03	10	147	2	DOID:0060903 (implicated_via_orthology)
Disease	Fanconi anemia (is_implicated_in)	BRCA2 FANCI	1.08e-03	10	147	2	DOID:13636 (is_implicated_in)
Disease	cytochrome p450 3a4 measurement	BCHE APOB	1.32e-03	11	147	2	EFO_0020303
Disease	hyperhomocysteinemia (implicated_via_orthology)	BCHE F8	1.32e-03	11	147	2	DOID:9279 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	ATG7 ATP1A4	1.57e-03	12	147	2	DOID:863 (implicated_via_orthology)
Disease	11beta-hydroxyandrosterone glucuronide measurement	SPAST NLRC4	1.57e-03	12	147	2	EFO_0800573
Disease	integral membrane protein 2B measurement	BCHE APOB	1.57e-03	12	147	2	EFO_0802634
Disease	disks large homolog 3 measurement	TEX11 MEF2C	1.57e-03	12	147	2	EFO_0802472
Disease	Fanconi anemia	BRCA2 FANCI	2.16e-03	14	147	2	cv:C0015625
Disease	Alcoholic Intoxication, Chronic	VWF TIPARP ADH4 ANAPC1 CDH12 CNR1	2.31e-03	268	147	6	C0001973
Disease	Proteinuria	VWF UNC13C	2.48e-03	15	147	2	HP_0000093
Disease	myelodysplastic syndrome (implicated_via_orthology)	ASXL1 ATG7	2.48e-03	15	147	2	DOID:0050908 (implicated_via_orthology)
Disease	Hypertriglyceridemia	BCHE APOB	2.48e-03	15	147	2	C0020557
Disease	ovarian cancer (is_implicated_in)	ITGA8 APOB BRCA2	2.77e-03	56	147	3	DOID:2394 (is_implicated_in)
Disease	Colorectal Carcinoma	STARD8 ABCA13 LAMC1 APOB MSH2 ABCA8 SERPINB5 ABCA5 DCHS1 EXO1	2.80e-03	702	147	10	C0009402
Disease	visceral adipose tissue measurement	HIVEP2 LEMD2 PKD1L3 ARMH2 PKD1 THNSL2 SLITRK6 UNC79	2.92e-03	481	147	8	EFO_0004765
Disease	keratinocyte carcinoma	TICAM1 BRCA2 EXO1 THNSL2	2.92e-03	118	147	4	EFO_0010176
Disease	response to efavirenz, virologic response measurement	PIGN IGSF10 SLC37A4	3.06e-03	58	147	3	EFO_0006904, EFO_0006906
Disease	neuroimaging measurement, brain volume measurement	EEF1AKMT4-ECE2 RGPD1 LAMC1 NOSTRIN TUBD1 SCAI	3.18e-03	286	147	6	EFO_0004346, EFO_0006930
Disease	noggin measurement	HIVEP2 MEF2C	3.58e-03	18	147	2	EFO_0021995
Disease	hair colour measurement	ASXL1 ZFYVE16 NIPAL3 PKD1L3 GPR161 FOLH1B UNC13C THNSL2 PLXNA1	3.80e-03	615	147	9	EFO_0007822
Disease	urate measurement, bone density	DPYSL3 TTC28 ABCA8 TIPARP GBP4 GBP5 A2ML1 CDH12 PDZD2	3.96e-03	619	147	9	EFO_0003923, EFO_0004531
Disease	X-11470 measurement	SPAST TTC27	3.99e-03	19	147	2	EFO_0021241
Disease	hippuric acid measurement	A2ML1 CDH12	3.99e-03	19	147	2	EFO_0010496
Disease	chemerin measurement	ATG7 UNC13C	3.99e-03	19	147	2	EFO_0004573
Disease	sodium-coupled monocarboxylate transporter 1 measurement	BCHE APOB	3.99e-03	19	147	2	EFO_0802076
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	MSH2 EXO1	3.99e-03	19	147	2	C2936783
Disease	age at menopause	MGAM TTC28 FANCM TIPARP FANCI EXO1	4.15e-03	302	147	6	EFO_0004704
Disease	verbal-numerical reasoning measurement	DMXL2 MEF2C NEGR1 ARMH3	4.25e-03	131	147	4	EFO_0008394
Disease	body weight	MGAM HIVEP2 NBEAL1 RGPD1 SLC44A2 TEX11 ACYP2 NEGR1 PKD1 FOLH1B TRIM13 UNC79 PLXNA1 PDZD2	4.27e-03	1261	147	14	EFO_0004338
Disease	anti-Mullerian hormone measurement	TTC28 MEF2C	4.42e-03	20	147	2	EFO_0004769
Disease	atherosclerosis (biomarker_via_orthology)	CASR JAK2	4.42e-03	20	147	2	DOID:1936 (biomarker_via_orthology)
Disease	Deep Vein Thrombosis	F8 JAK2	4.86e-03	21	147	2	C0149871
Disease	Venous Thrombosis	F8 JAK2	4.86e-03	21	147	2	C0042487
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	VWF SLC44A2	4.86e-03	21	147	2	EFO_0004286, EFO_0004792
Disease	Ovarian Failure, Premature	XPNPEP2 HFM1	4.86e-03	21	147	2	C0085215

Protein segments in the cluster

Peptide	Gene	Start	Entry
NASRQESFSSILAYK	ABCA5	1556	Q8WWZ7
FSNEKTISKLEYSNF	ACYP2	81	P14621
EDNGLKNSTFTYFTS	ARSD	341	P51689
FKSTEQKYLTLNTES	BCHE	521	P06276
TLSNSVFTFSYKKAQ	HSD3B1	321	P14060
TFSQYTVVSDINLAK	ADH4	151	P08319
FESTIKSETNSYLLL	ARMH2	156	H3BNL8
SYASSSRLLSNKNQF	CASR	166	P41180
LAAVTVKLYSSFDFN	CALHM3	26	Q86XJ0
VAVTSTNAAKIFNLY	DPYSL3	381	Q14195
NFLKDSYTALTSITA	GVINP1	491	Q7Z2Y8
SCFLNYLQKTEQTDT	GVINP1	676	Q7Z2Y8
STQKRYTFTNTFIID	GVINP1	2016	Q7Z2Y8
SSASSLKNVYFLLFD	MACROH2A2	341	Q9P0M6
LSDYSQLNESTTKES	FBXO34	491	Q9NWN3
DELIKNTQTYTFTIS	A2ML1	1406	A8K2U0
NTTVDYTLFESLCSK	CCR7	36	P32248
IYFNILENNSSSKTE	ABCA13	1561	Q86UQ4
DVQTSNLLITFLKYS	ARMH3	361	Q5T2E6
YFAVSNSDLSSVKLL	ASB14	361	A6NK59
EFETSSTYISILNQK	DMXL2	1761	Q8TDJ6
TSEIQELFDIFTYSK	LVRN	491	Q6Q4G3
KLDDISSNYTESFST	DMXL1	1996	Q9Y485
KLQLSSTSFNYSSSS	ASXL1	1446	Q8IXJ9
YSKSLSQSTSLFQST	ANO3	46	Q9BYT9
IQAVLASDYSFSQFK	ATP8B2	856	P98198
TSTILENYFKLLNSD	NBEAL1	291	Q6ZS30
INLETLQSAFYTEKF	JAK2	256	O60674
ENSFTIQYILDTSDK	TIPARP	191	Q7Z3E1
EKFSLSQESSYIATQ	LBR	151	Q14739
TSYSINTELSLFSKV	MPEG1	111	Q2M385
NSLDQEKVSSVFYTT	OR8D1	266	Q8WZ84
SYNESETKSTLLFGQ	KIF5B	306	P33176
NASFTYLTALTDSNI	LRWD1	626	Q9UFC0
RFTSKYVSSVLSFQE	LTN1	1596	O94822
YFQTTSTNLSLSNKI	RADX	611	Q6NSI4
FIISQDKSEKAYSSN	ANAPC1	131	Q9H1A4
EYSSISEKLSSTNFA	C8orf76	76	Q96K31
EVLIEYNFSISSFSK	FANCI	751	Q9NVI1
TYSLQQLSEDSKAFR	DCHS1	1141	Q96JQ0
KTLANLLTSNYISFT	OR8H2	81	Q8N162
SNVYATDKNSLSSLD	MYF5	191	P13349
LSSNKIFYLPNTTFT	LRRTM2	116	O43300
SAVSEASFSYKENLI	NIPAL3	21	Q6P499
QSSSAALSKFIAVYF	IL17RD	466	Q8NFM7
AALKYLIDNSFTVSS	MATN1	356	P21941
LQSDFTKYLTTADSS	LAMA3	2076	Q16787
VLTLSSFTSIFYLKN	NEGR1	336	Q7Z3B1
LYQESTSKSALSQEF	NLRC4	561	Q9NPP4
DTSSQLKKFYNQVST	ITIH2	481	P19823
QEYIANVTSSSSAKF	LEMD2	306	Q8NC56
ASAKLDVFQSYQSAT	GOLGA4	796	Q13439
TADISLKSSVYANAF	MGAM	1016	O43451
NLYNTLDSSITDKSE	KIAA1109	4531	Q2LD37
ALNSTFDYSEFSLEK	FANCM	1376	Q8IYD8
NKITAAIFYSISLTQ	MLYCD	281	O95822
DSKNFNTSRLDVYLS	LIPF	266	P07098
SSSNFDESLNSLKYA	KIF27	321	Q86VH2
SAESSQKKTSLYFDE	PCLO	1681	Q9Y6V0
SAYNISNSSTFTKSL	PLXNA1	1606	Q9UIW2
QTYSQEFSLTADSRK	PCDHGA9	751	Q9Y5G4
KDSLISESELSQYFA	PDZD2	856	O15018
SFQVASKSVLAALYS	PDE2A	706	O00408
FQLESTFDLKRYLSS	HMX1	216	Q9NP08
TYSLSFDSLFSAVKN	FOLH1B	316	Q9HBA9
NSASLFTASDYKVAS	MORF4L2	266	Q15014
NFTKAASTYSIDSVS	LAMP2	101	P13473
SFQDRLLTADQTKYS	LMTK2	316	Q8IWU2
YSSTLKFQAGFLNTT	LYPD4	171	Q6UWN0
IIFNSTNKLFQYAST	MEF2C	46	Q06413
LLSSSFVYNSVSTIN	GBP4	136	Q96PP9
LLSSTFVYNTVNKID	GBP5	121	Q96PP8
SKAISDAQITASSYF	F8	2201	P00451
IIFNSSNKLFQYAST	MEF2A	46	Q02078
NISLNYSLDESTFKE	ITGA8	601	P53708
KTLANLLTSNYISFT	OR8H3	81	Q8N146
LAYLSFADISSISNS	OR1S2	76	Q8NGQ3
ITNEDTNYISLTQKF	HFM1	76	A2PYH4
SSNQTEFKFDLTLNY	HFM1	501	A2PYH4
FITSSQSAAYAISKF	SLC37A4	51	O43826
FTVYISADSKSSNSN	EEF1AKMT4-ECE2	351	P0DPD8
NITYDFSFKSSVITL	APOB	3336	P04114
DTFVSLSYLQIFKIS	IGSF10	171	Q6WRI0
TLYNTNTLESFKTAD	ATG7	86	O95352
VEYSDTDFQSQKSLL	BRCA2	746	P51587
ETSTSLKDLFSQTLY	COL12A1	1616	Q99715
LKDLFSQTLYTVSVS	COL12A1	1621	Q99715
FFYAISSSKSSNVIV	GPR89A	366	B7ZAQ6
FFYAISSSKSSNVIV	GPR89B	366	P0CG08
SKALQEYSQSFIVSL	DAGLB	476	Q8NCG7
SQFSLEKYLSQEEQS	HAUS3	196	Q68CZ6
VNITEFYNKSLSSFK	CNR1	76	P21554
SYLLTLSNKFVFSLT	GPR161	56	Q8N6U8
AKTANDTSTEAYNLL	LAMC1	1201	P11047
TAVFLSTSNEAVYKI	SLC44A2	381	Q8IWA5
STAQYNFSIIASKVS	CDH12	451	P55289
KSTAISLFYELSEND	EEF2	71	P13639
TTNTSQKYIFVSLLS	GRAMD2A	151	Q8IUY3
LNTTYSFLTTFFKEI	HEXB	326	P07686
NLESSNSKYSLNTDS	CDC27	216	P30260
NSKYSLNTDSSVSYI	CDC27	221	P30260
FTNSKLTSLNEEYTK	MSH2	551	P43246
KSLYDKAATSFSEQQ	CFAP74	681	Q9C0B2
VAVTSTNAAKIFNLY	CRMP1	381	Q14194
KSTLFNTLLESDYCT	NOA1	351	Q8NC60
YQSAAVFKLSLTASN	PKD1	986	P98161
SFAKDTVLTYLTNFS	OR2B2	321	Q9GZK3
VLYNALFSSQSSKDT	RGPD1	376	P0DJD0
LSTENKSEFLLTDYF	NOSTRIN	271	Q8IVI9
SLVYFLSSTFKQEER	SPRING1	26	Q9H741
TNKIYKDDISNSSFV	RRAGC	96	Q9HB90
KYKTTNQSTEFLSFQ	SLITRK6	736	Q9H5Y7
SDFQQKISSVLSYNE	NIN	1696	Q8N4C6
GDTSYNSQIAKIFSS	RESF1	901	Q9HCM1
TDTQLVSFQSALLYT	SEC24A	796	O95486
STSSTSLNLKADFNY	SMG1	1216	Q96Q15
SLTVQDDYIFFKATS	SORCS2	346	Q96PQ0
FTALYSLELSKDQAT	PKD1L3	1171	Q7Z443
QIKTLSTSEQFYSRF	SHROOM2	1246	Q13796
SLSCTTQFLQYFLEK	THNSL2	116	Q86YJ6
QTVTSDVNKLSSFYS	SERPINB5	71	P36952
TQTTQLSLSFKLDYF	MT-ND5	71	P03915
SFNLEASLSKFSYID	VPS8	26	Q8N3P4
ATFFNISAASLTSKY	SPAST	401	Q9UBP0
SEDDLLSQYSLSFTK	EXO1	426	Q9UQ84
FTSKLTTTFLQIYQL	STARD8	656	Q92502
VKQSFDLEEYSLSQS	ABCA8	1571	O94911
LYLTSSTERFSQNFK	ADAM17	81	P78536
ESALLKFIEQSYSSV	ATP1A4	461	Q13733
FNSEQETITSLYKTS	CLCNKA	256	P51800
FNSEQETITSLYKTS	CLCNKB	256	P51801
RYKFENQSLDSISSS	XIRP2	1026	A4UGR9
FSKYEKSAVLVSNSQ	TUBD1	386	Q9UJT1
ITNTLSFATYLLATN	TBXAS1	346	P24557
LSNFSSYLTKTADFI	TRIM13	351	O60858
SYLTKTADFIEQSVF	TRIM13	356	O60858
KVLLQYAAIVSSDFS	UNC13C	1771	Q8NB66
STSEVLKYTLFQIFS	VWF	1356	P04275
LESSSEQKFYNFVIL	TICAM1	386	Q8IUC6
TAFSNYSATLKSQLS	TRIM75	221	A6NK02
SDFLQQTTSKIYSDK	TBC1D9	396	Q6ZT07
TLNAESYVSFTTKLD	TCTN1	186	Q2MV58
SQSYSYSSILNKSET	USP47	171	Q96K76
YLQQAFEKSTNASFT	ZNF281	671	Q9Y2X9
IIVDSSNSVAYKNFT	SCAI	431	Q8N9R8
FLNHLTSFKESYETQ	TEX11	896	Q8IYF3
KLTSIQFSYNTDITQ	PIGN	761	O95427
LSTDYKLSLFDLQTS	TTC28	1156	Q96AY4
KESFLTNSSYESSFL	SFTA2	31	Q6UW10
TNSSYESSFLELLEK	SFTA2	36	Q6UW10
SFSSLYKATFDNVTS	WDR4	356	P57081
LNSFTSSQVKEYLQS	TEX26	251	Q8N6G2
FANKSRFSSETLSYL	XPNPEP2	276	O43895
KTLSFFSLAANSLYS	TLR5	196	O60602
FNSTTTAEEKIDSYL	TTC27	56	Q6P3X3
TEYQRLFQSKSTDSE	HIVEP2	1996	P31629
SVSSLLLFNTTENLY	WASH6P	151	Q9NQA3
FLTEQYLQTTNIKSF	ZFYVE16	536	Q7Z3T8
LKDQDLSILSTSYQF	ZFYVE16	1436	Q7Z3T8
LSILSTSYQFAKEIA	ZFYVE16	1441	Q7Z3T8
SGTDIANTLKYFSQT	UNC79	31	Q9P2D8
DVYKFTNLLTSILDS	KYNU	446	Q16719