| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | activin receptor activity, type I | 5.84e-08 | 5 | 37 | 3 | GO:0016361 | |
| GeneOntologyMolecularFunction | activin receptor activity | 4.88e-07 | 9 | 37 | 3 | GO:0017002 | |
| GeneOntologyMolecularFunction | activin binding | 1.27e-06 | 12 | 37 | 3 | GO:0048185 | |
| GeneOntologyMolecularFunction | transmembrane receptor protein serine/threonine kinase activity | 6.53e-06 | 20 | 37 | 3 | GO:0004675 | |
| GeneOntologyMolecularFunction | I-SMAD binding | 4.46e-04 | 17 | 37 | 2 | GO:0070411 | |
| GeneOntologyMolecularFunction | transmembrane receptor protein kinase activity | 5.21e-04 | 85 | 37 | 3 | GO:0019199 | |
| GeneOntologyMolecularFunction | SMAD binding | 5.39e-04 | 86 | 37 | 3 | GO:0046332 | |
| GeneOntologyMolecularFunction | PDZ domain binding | 1.52e-03 | 123 | 37 | 3 | GO:0030165 | |
| GeneOntologyMolecularFunction | growth factor binding | 2.99e-03 | 156 | 37 | 3 | GO:0019838 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase binding | 3.39e-03 | 337 | 37 | 4 | GO:0031625 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase binding | 4.21e-03 | 358 | 37 | 4 | GO:0044389 | |
| GeneOntologyCellularComponent | activin receptor complex | 1.10e-07 | 6 | 38 | 3 | GO:0048179 | |
| GeneOntologyCellularComponent | plasma membrane protein complex | 6.86e-05 | 785 | 38 | 8 | GO:0098797 | |
| Domain | GS | 1.59e-07 | 7 | 32 | 3 | SM00467 | |
| Domain | GS_dom | 1.59e-07 | 7 | 32 | 3 | IPR003605 | |
| Domain | TGF_beta_GS | 1.59e-07 | 7 | 32 | 3 | PF08515 | |
| Domain | GS | 1.59e-07 | 7 | 32 | 3 | PS51256 | |
| Domain | Activin_recp | 5.44e-07 | 10 | 32 | 3 | IPR000472 | |
| Domain | Activin_recp | 5.44e-07 | 10 | 32 | 3 | PF01064 | |
| Domain | TGFB_receptor | 9.95e-07 | 12 | 32 | 3 | IPR000333 | |
| Domain | GPCR_2-like | 4.73e-03 | 60 | 32 | 2 | IPR017981 | |
| Domain | GPCR_2_secretin-like | 4.73e-03 | 60 | 32 | 2 | IPR000832 | |
| Domain | G_PROTEIN_RECEP_F2_4 | 4.89e-03 | 61 | 32 | 2 | PS50261 | |
| Domain | - | 8.47e-03 | 81 | 32 | 2 | 3.90.550.10 | |
| Domain | Nucleotide-diphossugar_trans | 9.93e-03 | 88 | 32 | 2 | IPR029044 | |
| Pathway | KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY | 8.40e-05 | 8 | 25 | 2 | M47849 | |
| Pathway | KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY | 8.40e-05 | 8 | 25 | 2 | M47846 | |
| Pathway | KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY | 8.40e-05 | 8 | 25 | 2 | M47847 | |
| Pathway | REACTOME_REGULATION_OF_SIGNALING_BY_NODAL | 1.97e-04 | 12 | 25 | 2 | M26952 | |
| Pathway | REACTOME_SIGNALING_BY_ACTIVIN | 3.13e-04 | 15 | 25 | 2 | MM14593 | |
| Pathway | REACTOME_SIGNALING_BY_ACTIVIN | 4.04e-04 | 17 | 25 | 2 | M26965 | |
| Pathway | REACTOME_SIGNALING_BY_NODAL | 7.47e-04 | 23 | 25 | 2 | M511 | |
| Pathway | WP_CYTOKINECYTOKINE_RECEPTOR_INTERACTION | 9.66e-04 | 254 | 25 | 4 | M48344 | |
| Pathway | REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS | 1.15e-03 | 118 | 25 | 3 | MM15588 | |
| Pubmed | 6.71e-08 | 8 | 38 | 3 | 16845371 | ||
| Pubmed | 2.63e-07 | 12 | 38 | 3 | 23342175 | ||
| Pubmed | 1.16e-06 | 2 | 38 | 2 | 35323108 | ||
| Pubmed | 1.16e-06 | 2 | 38 | 2 | 30804470 | ||
| Pubmed | Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. | 1.16e-06 | 2 | 38 | 2 | 15459392 | |
| Pubmed | 3.48e-06 | 3 | 38 | 2 | 22056140 | ||
| Pubmed | ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. | 3.48e-06 | 3 | 38 | 2 | 15485907 | |
| Pubmed | Activin isoforms signal through type I receptor serine/threonine kinase ALK7. | 3.48e-06 | 3 | 38 | 2 | 15196700 | |
| Pubmed | 3.48e-06 | 3 | 38 | 2 | 33342936 | ||
| Pubmed | 6.96e-06 | 4 | 38 | 2 | 26289399 | ||
| Pubmed | 6.96e-06 | 4 | 38 | 2 | 11356828 | ||
| Pubmed | 6.96e-06 | 4 | 38 | 2 | 21356369 | ||
| Pubmed | 6.96e-06 | 4 | 38 | 2 | 9738003 | ||
| Pubmed | 1.16e-05 | 5 | 38 | 2 | 18029401 | ||
| Pubmed | 1.74e-05 | 6 | 38 | 2 | 14517293 | ||
| Pubmed | 1.74e-05 | 6 | 38 | 2 | 8622651 | ||
| Pubmed | Roles of pathway-specific and inhibitory Smads in activin receptor signaling. | 2.43e-05 | 7 | 38 | 2 | 9892009 | |
| Pubmed | 2.43e-05 | 7 | 38 | 2 | 22202673 | ||
| Pubmed | 2.43e-05 | 7 | 38 | 2 | 16344855 | ||
| Pubmed | 2.43e-05 | 7 | 38 | 2 | 12065756 | ||
| Pubmed | 3.04e-05 | 55 | 38 | 3 | 15342483 | ||
| Pubmed | 3.24e-05 | 8 | 38 | 2 | 20663871 | ||
| Pubmed | Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. | 4.16e-05 | 9 | 38 | 2 | 12857866 | |
| Pubmed | Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. | 4.16e-05 | 9 | 38 | 2 | 14729481 | |
| Pubmed | 5.20e-05 | 10 | 38 | 2 | 15611116 | ||
| Pubmed | Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. | 6.35e-05 | 11 | 38 | 2 | 19758997 | |
| Pubmed | 6.35e-05 | 11 | 38 | 2 | 7791754 | ||
| Pubmed | 6.35e-05 | 11 | 38 | 2 | 21852401 | ||
| Pubmed | Synergistic interaction between Gdf1 and Nodal during anterior axis development. | 7.62e-05 | 12 | 38 | 2 | 16564040 | |
| Pubmed | 7.62e-05 | 12 | 38 | 2 | 25872870 | ||
| Pubmed | Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. | 9.00e-05 | 13 | 38 | 2 | 11278302 | |
| Pubmed | 1.05e-04 | 14 | 38 | 2 | 21791611 | ||
| Pubmed | 1.38e-04 | 16 | 38 | 2 | 11279102 | ||
| Pubmed | 2.90e-04 | 23 | 38 | 2 | 29742433 | ||
| Pubmed | GDF11 controls the timing of progenitor cell competence in developing retina. | 3.43e-04 | 25 | 38 | 2 | 15976303 | |
| Pubmed | Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis. | 3.43e-04 | 25 | 38 | 2 | 24835278 | |
| Pubmed | Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. | 3.72e-04 | 26 | 38 | 2 | 23034635 | |
| Pubmed | Conditionals by inversion provide a universal method for the generation of conditional alleles. | 4.01e-04 | 27 | 38 | 2 | 23918385 | |
| Pubmed | 4.61e-04 | 331 | 38 | 4 | 20634891 | ||
| Pubmed | DNA Damage Regulates Translation through β-TRCP Targeting of CReP. | 6.76e-04 | 35 | 38 | 2 | 26091241 | |
| Pubmed | 7.15e-04 | 36 | 38 | 2 | 38070861 | ||
| Pubmed | 7.42e-04 | 162 | 38 | 3 | 23012479 | ||
| Pubmed | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. | 7.87e-04 | 382 | 38 | 4 | 19170196 | |
| Interaction | ACVR1C interactions | 2.89e-06 | 16 | 36 | 3 | int:ACVR1C | |
| GeneFamily | Type 1 receptor serine/threonine kinases | 7.17e-08 | 7 | 24 | 3 | 345 | |
| CoexpressionAtlas | DevelopingKidney_e15.5_Proximal Tubules_emap-28005_top-relative-expression-ranked_1000 | 3.17e-05 | 758 | 36 | 8 | gudmap_developingKidney_e15.5_Proximal Tubules_1000 | |
| ToppCell | 343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells) | 6.83e-06 | 144 | 38 | 4 | 5e948d4cb913ccd8f82262a1b4d20967aadab3ab | |
| ToppCell | droplet-Lung-LUNG-1m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.41e-05 | 173 | 38 | 4 | 53e97835d7a518c278e7b90a0734eb0095d6aa33 | |
| ToppCell | droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.41e-05 | 173 | 38 | 4 | 3612772632ddf11eb48579cae9a8ccab6b3f1f52 | |
| ToppCell | droplet-Lung-LUNG-1m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.41e-05 | 173 | 38 | 4 | 889a880de5fc19d26b82cfef3067869a28ef17ca | |
| ToppCell | droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.41e-05 | 173 | 38 | 4 | 4dc261ebcdb9bdcfca1451da1bd254f0dc5de203 | |
| ToppCell | kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group | 1.54e-05 | 177 | 38 | 4 | c9e8149639551a4c8daa90fcb2b895fdcff2e2ba | |
| ToppCell | renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group | 1.61e-05 | 179 | 38 | 4 | d3438fed0d85d5ed5afa8ff820c45143d77b6c0d | |
| ToppCell | droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.75e-05 | 183 | 38 | 4 | ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f | |
| ToppCell | droplet-Lung-nan-3m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.79e-05 | 184 | 38 | 4 | 3261d767d5e3d9e9fbac22ad73ca14e44beed89c | |
| ToppCell | droplet-Lung-nan-21m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.87e-05 | 186 | 38 | 4 | 8f77e552e613b6e124443c7f6ef5c1316a5ff8db | |
| ToppCell | droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.87e-05 | 186 | 38 | 4 | f1aa0c58336d23bcbe52a59e7af954d20085bdb6 | |
| ToppCell | mLN-T_cell-gd_T|T_cell / Region, Cell class and subclass | 2.30e-05 | 196 | 38 | 4 | 8f476408cd5a4ea9d25c763c66565343d7989b38 | |
| Drug | TAAD | 5.15e-06 | 21 | 37 | 3 | CID000133445 | |
| Drug | ap1-6 | 6.84e-06 | 23 | 37 | 3 | CID003030073 | |
| Disease | transforming growth factor beta measurement | 4.98e-04 | 27 | 36 | 2 | EFO_0004818 | |
| Disease | stimulant use measurement | 5.36e-04 | 28 | 36 | 2 | EFO_0600076 | |
| Disease | obsessive-compulsive symptom measurement | 6.58e-04 | 31 | 36 | 2 | EFO_0007802 | |
| Disease | follicle stimulating hormone measurement | 7.46e-04 | 33 | 36 | 2 | EFO_0004768 | |
| Disease | Borderline personality disorder | 8.40e-04 | 35 | 36 | 2 | HP_0012076 | |
| Disease | neutrophil count | 1.23e-03 | 1382 | 36 | 7 | EFO_0004833 | |
| Disease | major depressive episode | 1.51e-03 | 47 | 36 | 2 | EFO_0007634 | |
| Disease | neutrophil count, eosinophil count | 2.22e-03 | 213 | 36 | 3 | EFO_0004833, EFO_0004842 | |
| Disease | Abnormality of chromosome segregation | 2.45e-03 | 60 | 36 | 2 | HP_0002916 | |
| Disease | neutrophil count, basophil count | 2.56e-03 | 224 | 36 | 3 | EFO_0004833, EFO_0005090 | |
| Disease | SARS-CoV-2 antibody measurement, response to COVID-19 vaccine | 2.61e-03 | 62 | 36 | 2 | EFO_0803360, EFO_0803362 | |
| Disease | magnesium measurement | 2.96e-03 | 66 | 36 | 2 | EFO_0004845 | |
| Disease | opioid dependence | 3.00e-03 | 237 | 36 | 3 | EFO_0005611 | |
| Disease | common carotid intimal medial thickness | 3.04e-03 | 67 | 36 | 2 | EFO_0004860 | |
| Disease | FEV/FEC ratio | 3.42e-03 | 1228 | 36 | 6 | EFO_0004713 | |
| Disease | granulocyte count | 3.65e-03 | 254 | 36 | 3 | EFO_0007987 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| MNLSSLAWEQMGRYR | 281 | A8MTB9 | |
| ENRALWMMIKRCFGY | 1131 | Q4VNC1 | |
| KMMRECWYANGAARL | 471 | P36896 | |
| VMGRIMRECWYANGA | 456 | Q8NER5 | |
| ANCSFWNYSERTMMG | 786 | O95490 | |
| FNWYNMRNCILADEM | 981 | Q9P2D1 | |
| ALTEAVRWYRMNMGG | 246 | Q17RG1 | |
| NMMGYNTDRLAWTRN | 666 | Q9H1A4 | |
| GNFWLLSLMRCYTEM | 1696 | Q71F56 | |
| QSLMEYAWGRAAAAM | 66 | Q96FX8 | |
| CYEDMGNNTANWRML | 196 | P25025 | |
| MMRGSGRWNDAFCDR | 261 | P06734 | |
| CYQMGLMSRYVESWR | 146 | Q6IPT4 | |
| MSCESSMVLGYWDIR | 1 | P21266 | |
| LMRQYGFAWPDRMRC | 121 | Q9H461 | |
| MCSPSRAGMYQGQWR | 146 | Q9H6K1 | |
| RAGMYQGQWRMCTAT | 151 | Q9H6K1 | |
| MGSAYHWEARRRQMA | 1 | A0A1B0GVQ3 | |
| RQSCMNTFASWFGYM | 701 | Q16394 | |
| RWMVYRQIMDSSECF | 776 | Q5TEA3 | |
| CRSRTKNMMWYGVLG | 791 | Q16760 | |
| MAMAYLAWRLARRSC | 1 | O75521 | |
| DCGASSNRLEMQWNM | 3591 | Q8NDH2 | |
| MLDSRAAYSNFWCGM | 191 | Q8NBJ5 | |
| NLSGCRSYWTMLMGQ | 1661 | Q9Y238 | |
| WGAAEIMEAYSMARQ | 231 | O43448 | |
| RQDQYDCALWMMTFS | 481 | Q96RN1 | |
| WNACYDMLMSSGQRR | 1741 | Q6ZNJ1 | |
| MVWSEAMARGCFLNA | 116 | A6NGN4 | |
| RTGSRTYMCSWQGEM | 426 | Q9NY99 | |
| SVYMEAKNRGWCEDM | 881 | Q5T5J6 | |
| VMAKIMRECWYANGA | 466 | P36897 | |
| SFVCWSRGFMEMNGR | 121 | Q9Y679 | |
| SGHNSLFWYRQTMMR | 46 | P01733 | |
| YDRSLRVWSMDNMIC | 621 | Q6Q0C0 | |
| RKVYGMENRDMWCTA | 386 | Q6ZNC4 | |
| CWAAMGSLYAEMTEN | 66 | E9PQX1 | |
| CMHSALDMTRYWRQL | 186 | Q96PM5 | |
| MTRGAWMCRQYDDGL | 1 | B1AL88 |