Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	PHOX2A GSX1 MYPOP KMT2D USF3 ATF5 FEZF1 NFKB2 YLPM1 TLX3 ZBTB22 GBX1 VAX2 ZFHX3 MLXIP SIX2 ETV3L	1.68e-04	1412	90	17	GO:0000981
Domain	Homeobox_CS	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	2.79e-05	186	88	7	IPR017970
Domain	-	PHOX2A GSX1 MYPOP TLX3 GBX1 VAX2 ZFHX3 SIX2	5.67e-05	283	88	8	1.10.10.60
Domain	Homeobox	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	1.19e-04	234	88	7	PF00046
Domain	HOMEOBOX_1	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	1.25e-04	236	88	7	PS00027
Domain	HOX	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	1.29e-04	237	88	7	SM00389
Domain	HOMEOBOX_2	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	1.35e-04	239	88	7	PS50071
Domain	Homeobox_dom	PHOX2A GSX1 TLX3 GBX1 VAX2 ZFHX3 SIX2	1.35e-04	239	88	7	IPR001356
Domain	Homeodomain-like	PHOX2A GSX1 MYPOP TLX3 GBX1 VAX2 ZFHX3 SIX2	1.71e-04	332	88	8	IPR009057
Domain	HTH_motif	PHOX2A GSX1 VAX2 SIX2	3.15e-04	69	88	4	IPR000047
Domain	Kinase_OSR1/WNK_CCT	WNK4 WNK2	3.25e-04	6	88	2	IPR024678
Domain	OSR1_C	WNK4 WNK2	3.25e-04	6	88	2	PF12202
Domain	Homeobox_metazoa	GSX1 TLX3 GBX1 VAX2	8.63e-04	90	88	4	IPR020479
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 CNPPD1 PRR12 PRKD2 FAM193B KMT2D ITPRIPL2 SETD1B SH3RF1 CELSR2 PPRC1 CDK12 MEX3D NFKB2 OBSCN FBRSL1 C15orf39 MLLT6 MLXIP SRCAP MBD6 ARID1A CNTROB EP300 WNK2	2.38e-16	1105	96	25	35748872
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRRG2 USF3 ATF5 POM121 YLPM1 ARHGEF18 MLLT6 NYAP1 CCDC141 ZNF804A PRRC1 WNK4 WNK2 MRTFA SON	9.94e-13	430	96	15	35044719
Pubmed	Interaction network of human early embryonic transcription factors.	TET2 PRR12 KMT2D TLE5 FBRSL1 C15orf39 ZFHX3 MBD6 ARID1A EP300	5.04e-08	351	96	10	38297188
Pubmed	Human transcription factor protein interaction networks.	TET2 PRR12 KMT2D TLE5 NFKB2 YLPM1 TLX3 FBRSL1 C15orf39 MLLT6 ZFHX3 EIF3G SRCAP MBD6 FIGN ARID1A EP300 CNOT3	6.53e-08	1429	96	18	35140242
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2D SETD1B HDAC6 SRCAP MBD6 ARID1A EP300	2.84e-07	157	96	7	30186101
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	TDRD7 FAM193B POM121 TLE5 MLLT6 MBD6 RTL8C CNTROB ZNF804A SSPOP WNK2	9.81e-07	608	96	11	16713569
Pubmed	A census of human transcription factors: function, expression and evolution.	PHOX2A GSX1 MYPOP KMT2D USF3 ATF5 NFKB2 TLX3 GBX1 VAX2 ZFHX3 MLXIP SIX2	1.32e-06	908	96	13	19274049
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	KMT2D SETD1B SRCAP ARID1A CNOT3	1.41e-06	69	96	5	28481362
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	NPIPB4 CELSR2 NPIPB3 WASF1 SNX19	3.53e-06	83	96	5	9039502
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	PRR12 KMT2D CDK12 ARID1A EP300	3.53e-06	83	96	5	28794006
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TET2 PRR12 TLE5 FBRSL1 C15orf39 EP300	4.23e-06	152	96	6	38360978
Pubmed	CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.	CDK12 ARID1A	7.54e-06	2	96	2	37357968
Pubmed	ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma.	HDAC6 ARID1A	7.54e-06	2	96	2	35167193
Pubmed	Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma.	HDAC6 ARID1A	7.54e-06	2	96	2	30787326
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	7.54e-06	2	96	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	7.54e-06	2	96	2	34910522
Pubmed	Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor.	HDAC6 CCDC141	7.54e-06	2	96	2	27737934
Pubmed	Somatic mutations in KMT2D and TET2 associated with worse prognosis in Epstein-Barr virus-associated T or natural killer-cell lymphoproliferative disorders.	TET2 KMT2D	7.54e-06	2	96	2	31311407
Pubmed	Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells.	EP300 MRTFA	7.54e-06	2	96	2	26476216
Pubmed	Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.	FEZF1 ZFHX3 GFRA3	9.05e-06	15	96	3	31812516
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TET2 PRR12 KMT2D FBRSL1 C15orf39 MYO15A ARID1A EP300	1.51e-05	398	96	8	35016035
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	PRR12 PRRG2 MYO15A ZNF804A SNX19 EP300 GFRA3	2.18e-05	303	96	7	25056061
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.26e-05	3	96	2	30801007
Pubmed	Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity.	HDAC6 EP300	2.26e-05	3	96	2	19344692
Pubmed	p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.	ATF5 EP300	2.26e-05	3	96	2	21791614
Pubmed	The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.	KMT2D EP300	2.26e-05	3	96	2	37410700
Pubmed	Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells.	EP300 MRTFA	2.26e-05	3	96	2	25746323
Pubmed	ARID1A-mutated ovarian cancers depend on HDAC6 activity.	HDAC6 ARID1A	2.26e-05	3	96	2	28737768
Pubmed	CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.	WASF1 TRIP10	2.26e-05	3	96	2	19631450
Pubmed	Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene.	EP300 MRTFA	2.26e-05	3	96	2	24096006
Pubmed	Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.	KMT2D ARID1A	2.26e-05	3	96	2	27387124
Pubmed	Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.	SETD1B MRTFA	2.26e-05	3	96	2	22927943
Pubmed	Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.	SRCAP EP300	2.26e-05	3	96	2	10347196
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	2.26e-05	3	96	2	11948212
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	TET2 KMT2D	2.26e-05	3	96	2	26551667
Pubmed	Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.	PPRC1 NFKB2	2.26e-05	3	96	2	26942574
Pubmed	P300 transcriptional repression is mediated by SUMO modification.	HDAC6 EP300	2.26e-05	3	96	2	12718889
Pubmed	A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.	KMT2D EP300	2.26e-05	3	96	2	28732206
Pubmed	The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development.	FIGNL2 FIGN	2.26e-05	3	96	2	11017077
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PRKD2 MALT1 HDAC6 MEX3D NFKB2 FBRSL1 C15orf39 PHETA1 MLXIP CNTROB CNOT3 MRTFA	2.93e-05	1038	96	12	26673895
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	PHOX2A GSX1 FEZF1 GBX1 ZFHX3	3.14e-05	130	96	5	19386638
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2D YLPM1 ZFHX3 ARID1A EP300 SON	3.45e-05	220	96	6	35785414
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2D ARID1A	4.51e-05	4	96	2	34645806
Pubmed	CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.	PIWIL2 EP300	4.51e-05	4	96	2	33190089
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	4.51e-05	4	96	2	18849963
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2D EP300	4.51e-05	4	96	2	28398509
Pubmed	Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.	SRCAP EP300	4.51e-05	4	96	2	11581372
Pubmed	Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma.	KMT2D ARID1A	4.51e-05	4	96	2	26138514
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK4 WNK2	4.51e-05	4	96	2	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK4 WNK2	4.51e-05	4	96	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK4 WNK2	4.51e-05	4	96	2	11498583
Pubmed	ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.	ARID1A EP300	4.51e-05	4	96	2	33176148
Pubmed	An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.	HDAC6 EP300	4.51e-05	4	96	2	23133622
Pubmed	p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation.	ATF5 EP300	4.51e-05	4	96	2	24216764
Pubmed	Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.	HDAC6 EP300	4.51e-05	4	96	2	22778253
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PRR12 MYPOP KMT2D ZC3H13 YLPM1 TLX3 ZFC3H1 MLXIP SRCAP ARID1A SIX2 EP300 SON	5.66e-05	1294	96	13	30804502
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	ATF5 NFKB2 ARID1A	6.35e-05	28	96	3	30037996
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRR12 FAM193B USF3 POM121 SH3RF1 ARHGEF18 ZFC3H1 CNOT3	6.86e-05	493	96	8	15368895
Pubmed	cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.	CTAGE9 CTAGE4	7.50e-05	5	96	2	12839582
Pubmed	Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.	HDAC6 EP300	7.50e-05	5	96	2	23962722
Pubmed	HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity.	HDAC6 EP300	7.50e-05	5	96	2	23402884
Pubmed	RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription.	HDAC6 EP300	7.50e-05	5	96	2	15102857
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	7.50e-05	5	96	2	24920589
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TET2 PRR12 KMT2D TLE5 YLPM1 ARID1A	1.03e-04	268	96	6	33640491
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK4 WNK2	1.12e-04	6	96	2	21733846
Pubmed	Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.	HDAC6 EP300	1.57e-04	7	96	2	26719334
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK4 WNK2	1.57e-04	7	96	2	20525693
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D NFKB2	1.57e-04	7	96	2	19219072
Pubmed	Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.	HDAC6 EP300	1.57e-04	7	96	2	17872950
Pubmed	LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.	KMT2D EP300	1.57e-04	7	96	2	37166352
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	GSX1 ATF5 NFKB2 TLX3 ZBTB22 VAX2 MLXIP EP300 CNOT3 MRTFA	1.58e-04	877	96	10	20211142
Pubmed	Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.	KLHL29 CELSR2 ZFHX3	1.73e-04	39	96	3	21347282
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HDAC6 CDK12 ZC3H13 MLXIP	1.74e-04	100	96	4	10048485
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK4 WNK2	2.09e-04	8	96	2	23838290
Pubmed	Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.	HDAC6 EP300	2.09e-04	8	96	2	24413532
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	TLE5 SIX2	2.09e-04	8	96	2	12441302
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	2.09e-04	8	96	2	21165971
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK4 WNK2	2.09e-04	8	96	2	23387299
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2D SETD1B	2.09e-04	8	96	2	23130995
Pubmed	Differential expression of HDAC and HAT genes in atrophying skeletal muscle.	HDAC6 EP300	2.09e-04	8	96	2	26372908
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2D SETD1B	2.09e-04	8	96	2	22266653
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PPRC1 ARHGEF18 ZFC3H1 SSPOP	2.10e-04	105	96	4	9628581
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	POM121 SETD1B YLPM1 ZFC3H1 SRCAP ARID1A TRIP10	2.24e-04	440	96	7	34244565
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KLHL29 MALT1 USF3 TLE5 OBSCN FBRSL1 ARHGEF18 IGSF9 ZFHX3 ARID1A SSPOP EP300 WNK2	2.28e-04	1489	96	13	28611215
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD1B SH3RF1 NFKB2 FBRSL1 C15orf39 SRCAP ARID1A CNOT3	2.29e-04	588	96	8	38580884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PRKD2 MALT1 HDAC6 P3H3 FBRSL1 VAX2 ZFHX3 SRCAP ARID1A EP300 SON	2.59e-04	1116	96	11	31753913
Pubmed	Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.	HDAC6 EP300	2.68e-04	9	96	2	25770209
Pubmed	Identification of novel CBP interacting proteins in embryonic orofacial tissue.	TRIP10 CNOT3	2.68e-04	9	96	2	15752756
Pubmed	GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.	HDAC6 NFKB2	2.68e-04	9	96	2	15469820
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	GBX1 MYO15A	2.68e-04	9	96	2	23144817
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2D SETD1B	2.68e-04	9	96	2	22665483
Pubmed	Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development.	PHOX2A TLX3	2.68e-04	9	96	2	15240857
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR12 KMT2D POM121 CDK12 YLPM1 ARID1A EP300	2.82e-04	457	96	7	32344865
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2D HDAC6 CDK12 ZC3H13 YLPM1 EIF3G CNOT3 MRTFA SON	2.96e-04	774	96	9	15302935
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ZBTB22 EIF3G ARID1A CNTROB EP300 SON	3.26e-04	332	96	6	37433992
Pubmed	Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.	TDRD7 PIWIL2	3.34e-04	10	96	2	19584108
Pubmed	Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.	TLX3 GBX1	3.34e-04	10	96	2	33996801
Pubmed	Human ALKBH4 interacts with proteins associated with transcription.	ZFHX3 EP300	3.34e-04	10	96	2	23145062
Pubmed	EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.	ARID1A EP300	3.34e-04	10	96	2	35210568
Pubmed	Hoxb1 controls anteroposterior identity of vestibular projection neurons.	PHOX2A TLX3	4.08e-04	11	96	2	22485187
Interaction	TLE3 interactions	TET2 PRR12 KMT2D POM121 TLE5 CDK12 TLX3 FBRSL1 C15orf39 MLLT6 ZFHX3 FIGN ARID1A SIX2 EP300 SON	9.60e-12	376	90	16	int:TLE3
Interaction	TOP3B interactions	VWA5B2 CNPPD1 PRR12 PRKD2 FAM193B KMT2D ITPRIPL2 SETD1B SH3RF1 CELSR2 PPRC1 CDK12 MEX3D NFKB2 OBSCN FBRSL1 C15orf39 MLLT6 MLXIP SRCAP MBD6 ARID1A CNTROB EP300 WNK2	3.49e-09	1470	90	25	int:TOP3B
Interaction	PAX9 interactions	PRR12 KMT2D TLE5 FBRSL1 C15orf39 ZFHX3 FIGN ARID1A EP300	6.65e-09	130	90	9	int:PAX9
Interaction	HNF1B interactions	TET2 PRR12 KMT2D TLE5 TLX3 MLLT6 ZFHX3 MBD6 ARID1A EP300	1.30e-08	190	90	10	int:HNF1B
Interaction	CRX interactions	TET2 PRR12 KMT2D TLE5 TLX3 FBRSL1 C15orf39 MLLT6 ZFHX3 ARID1A EP300	1.78e-08	254	90	11	int:CRX
Interaction	TBR1 interactions	TET2 PRR12 KMT2D TLE5 FBRSL1 ZFHX3 ARID1A EP300	4.02e-08	113	90	8	int:TBR1
Interaction	EGR2 interactions	TET2 PRR12 KMT2D TLE5 FBRSL1 C15orf39 ZFHX3 ARID1A EP300	7.24e-08	171	90	9	int:EGR2
Interaction	GCM1 interactions	TET2 PRR12 KMT2D FBRSL1 ARID1A EP300	5.87e-07	68	90	6	int:GCM1
Interaction	PAX8 interactions	TET2 PRR12 KMT2D TLE5 FBRSL1 ARID1A EP300	6.52e-07	111	90	7	int:PAX8
Interaction	TLX3 interactions	TET2 PRR12 KMT2D TLE5 TLX3 FBRSL1 C15orf39 ZFHX3 ARID1A EP300	6.98e-07	291	90	10	int:TLX3
Interaction	PAX6 interactions	PRR12 KMT2D TLE5 FBRSL1 VAX2 MLLT6 ZFHX3 SRCAP ARID1A TRIP10 EP300	7.04e-07	366	90	11	int:PAX6
Interaction	PAX7 interactions	PRR12 KMT2D TLE5 FBRSL1 ZFHX3 ARID1A EP300	1.38e-06	124	90	7	int:PAX7
Interaction	SOX7 interactions	TET2 PRR12 KMT2D C15orf39 ARID1A EP300	1.79e-06	82	90	6	int:SOX7
Interaction	IRF4 interactions	PRR12 KMT2D TLE5 TLX3 ARID1A EP300	2.21e-06	85	90	6	int:IRF4
Interaction	GSC interactions	PRR12 KMT2D TLE5 C15orf39 ZFHX3 EP300	2.53e-06	87	90	6	int:GSC
Interaction	FOXI1 interactions	PRR12 KMT2D TLE5 FBRSL1 ARID1A EP300	3.51e-06	92	90	6	int:FOXI1
Interaction	FEV interactions	PRR12 KMT2D TLE5 FBRSL1 C15orf39 ZFHX3 ARID1A EP300	3.53e-06	203	90	8	int:FEV
Interaction	ERG interactions	TET2 PRR12 KMT2D TLE5 FBRSL1 C15orf39 ARID1A EP300	7.05e-06	223	90	8	int:ERG
Interaction	SP7 interactions	TET2 PRR12 KMT2D TLE5 YLPM1 FBRSL1 C15orf39 ARID1A EP300	8.70e-06	304	90	9	int:SP7
Interaction	TBXT interactions	PRR12 KMT2D TLE5 FBRSL1 ARID1A EP300	1.34e-05	116	90	6	int:TBXT
Interaction	TLX1 interactions	PRR12 KMT2D TLE5 FBRSL1 ZFHX3 ARID1A EP300	1.35e-05	175	90	7	int:TLX1
Interaction	GATA3 interactions	PRR12 KMT2D TLE5 FBRSL1 MLLT6 ARID1A EP300	2.07e-05	187	90	7	int:GATA3
Interaction	NFIA interactions	PRR12 KMT2D TLE5 TLX3 ARID1A EP300 SON	2.14e-05	188	90	7	int:NFIA
Interaction	NUP43 interactions	TDRD7 KMT2D POM121 SETD1B CDK12 ZC3H13 MLLT6 ZFHX3 ZFC3H1 SRCAP ARID1A SON	2.15e-05	625	90	12	int:NUP43
Interaction	GATA2 interactions	PRR12 KMT2D TLE5 FBRSL1 ZFHX3 ARID1A EP300	3.08e-05	199	90	7	int:GATA2
Interaction	TLX2 interactions	PRR12 KMT2D TLE5 FBRSL1 ZFHX3 ARID1A	4.21e-05	142	90	6	int:TLX2
Interaction	SOCS7 interactions	PRKD2 SH3RF1 CELSR2 P3H3	6.76e-05	49	90	4	int:SOCS7
Interaction	NFIX interactions	PRR12 KMT2D TLE5 TLX3 ZFHX3 SRCAP ARID1A	7.09e-05	227	90	7	int:NFIX
Interaction	KLF3 interactions	KMT2D TLE5 FBRSL1 ZFHX3 MBD6 ARID1A EP300	7.29e-05	228	90	7	int:KLF3
Interaction	EYA4 interactions	TET2 PRR12 TLE5 FBRSL1 C15orf39 SIX2 EP300	1.09e-04	243	90	7	int:EYA4
Interaction	TEAD1 interactions	PRR12 KMT2D FBRSL1 ZFHX3 ARID1A EP300	1.38e-04	176	90	6	int:TEAD1
Interaction	RBPJL interactions	CELSR2 TLX3 EP300	1.43e-04	23	90	3	int:RBPJL
Interaction	KLF5 interactions	TET2 PRR12 KMT2D TLE5 ARID1A EP300	2.41e-04	195	90	6	int:KLF5
Interaction	ARHGAP12 interactions	PRR12 YLPM1 WASF1 TRIP10	2.43e-04	68	90	4	int:ARHGAP12
Interaction	FOXL1 interactions	PRR12 KMT2D HDAC6 TLE5 FBRSL1 ZFHX3	2.48e-04	196	90	6	int:FOXL1
Interaction	ETV4 interactions	PRR12 KMT2D ARID1A EP300	2.58e-04	69	90	4	int:ETV4
Interaction	SPATA1 interactions	C15orf39 EP300 WNK2	3.54e-04	31	90	3	int:SPATA1
Interaction	NFIC interactions	TET2 PRR12 KMT2D TLX3 FBRSL1 ARID1A	3.59e-04	210	90	6	int:NFIC
Interaction	GOLGA2 interactions	PRR12 FAM193B KMT2D POM121 TLE5 GGN MLLT6 ZFHX3 EIF3G ZFC3H1 EP300	4.17e-04	733	90	11	int:GOLGA2
Interaction	SOX15 interactions	PRR12 KMT2D TLE5 ARID1A EP300	4.26e-04	141	90	5	int:SOX15
Interaction	NFIB interactions	PRR12 KMT2D TLE5 TLX3 ARID1A	4.40e-04	142	90	5	int:NFIB
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5	6.54e-05	37	96	3	16p12.2
Cytoband	19p13.3	TLE5 MEX3D ARHGEF18 PEAK3 TRIP10	1.47e-04	237	96	5	19p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PRR36 TLE5 MEX3D ARHGEF18 EIF3G PEAK3 GDF1 TRIP10	2.76e-04	797	96	8	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	ITPRIPL2 NPIPB4 NPIPB3 NPIPB5	4.83e-04	172	96	4	chr16p12
Cytoband	15q15.3	STRC STRCP1	1.26e-03	25	96	2	15q15.3
Coexpression	GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_AND_A3R_INH_PRETREAT_IN_MAST_CELL_DN	FAM193B KMT2D HDAC6 SH3RF1 CELSR2 ARHGEF18 ZFC3H1 MBD6	6.63e-07	199	95	8	M7319
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	MYPOP KMT2D ATF5 PPRC1 FBRSL1 NPIPB3 SRCAP CNTROB CNOT3	3.94e-06	338	95	9	M17094
Coexpression	GSE39820_CTRL_VS_TGFBETA3_IL6_IL23A_CD4_TCELL_DN	CNPPD1 MALT1 ATF5 MEX3D PHETA1 PIWIL2 TRIP10	8.22e-06	199	95	7	M5614
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	CNPPD1 PRR12 PRRG2 ATF5 HDAC6 SH3RF1 CELSR2 HCN4 TLE5 PPRC1 MEX3D ZBTB22 IGSF9 MLLT6 ZFHX3 MBD6 FIGN WASF1 SIX2 WNK4 WNK2	5.97e-08	1275	90	21	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD7 TET2 FAM193B MYPOP ITPRIPL2 EP300	4.44e-07	133	96	6	f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD7 TET2 FAM193B MYPOP ITPRIPL2 EP300	4.44e-07	133	96	6	292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	FAM193B GBX1 MLLT6 MBD6 FIGN	7.93e-06	126	96	5	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	VWA5B2 PRR12 PRR36 ZFHX3 SRCAP SON	4.62e-06	104	94	6	ctd:C000595015
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	ATF5 SETD1B PPRC1 ARID1A ZNF804A EP300 CNOT3	9.16e-06	178	94	7	4184_DN
Drug	Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; PC3; HT_HG-U133A	CELSR2 P3H3 NFKB2 C15orf39 ZFHX3 SIX2 MRTFA	1.71e-05	196	94	7	4580_DN
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; HL60; HT_HG-U133A	KLHL29 ANGPTL2 HDAC6 NFKB2 YLPM1 MYO15A ARID1A	1.89e-05	199	94	7	3095_UP
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	8.79e-06	2	88	2	DOID:0110471 (implicated_via_orthology)
Disease	T-Cell Lymphoma	KMT2D ARID1A EP300	1.40e-05	16	88	3	C0079772
Disease	triglyceride measurement, coronary artery disease	SETD1B FBRSL1	5.26e-05	4	88	2	EFO_0001645, EFO_0004530
Disease	Sezary Syndrome	TET2 KMT2D ARID1A	7.12e-05	27	88	3	C0036920
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK2	1.31e-04	6	88	2	DOID:4479 (implicated_via_orthology)
Disease	creatinine measurement	TET2 PRKD2 CELSR2 CDK12 OBSCN ARHGEF18 VAX2 ZFHX3 REPS2 ARID1A MRTFA	1.81e-04	995	88	11	EFO_0004518
Disease	Adenoid Cystic Carcinoma	SRCAP ARID1A EP300 SON	2.33e-04	100	88	4	C0010606
Disease	familial sick sinus syndrome	ZFHX3 CCDC141	2.43e-04	8	88	2	MONDO_0012061
Disease	sick sinus syndrome	ZFHX3 CCDC141	2.43e-04	8	88	2	MONDO_0001823
Disease	neuroticism measurement, cognitive function measurement	KLHL29 TET2 YLPM1 ZFHX3 FIGN ARID1A ZNF804A GFRA3	2.92e-04	566	88	8	EFO_0007660, EFO_0008354
Disease	HYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA	FEZF1 CCDC141	4.75e-04	11	88	2	146110
Disease	Hypogonadotropic hypogonadism 7 with or without anosmia	FEZF1 CCDC141	4.75e-04	11	88	2	cv:C0342384
Disease	Diffuse Large B-Cell Lymphoma	MALT1 KMT2D EP300	6.01e-04	55	88	3	C0079744
Disease	lung non-small cell carcinoma (is_implicated_in)	TET2 KMT2D ZFHX3 ARID1A	8.09e-04	139	88	4	DOID:3908 (is_implicated_in)
Disease	stomach cancer (is_marker_for)	TET2 KMT2D CDK12 ARID1A	8.76e-04	142	88	4	DOID:10534 (is_marker_for)
Disease	breast carcinoma (is_marker_for)	KMT2D ZFHX3 EP300	1.02e-03	66	88	3	DOID:3459 (is_marker_for)
Disease	omega-3 polyunsaturated fatty acid measurement, diet measurement	GSX1 CCDC141	1.03e-03	16	88	2	EFO_0008111, EFO_0010119
Disease	1-Methylhistidine measurement	KIF2B CDK12	1.16e-03	17	88	2	EFO_0021543
Disease	Idiopathic hypogonadotropic hypogonadism	FEZF1 CCDC141	1.30e-03	18	88	2	C0342384
Disease	Colorectal Neoplasms	CNPPD1 TET2 PHETA1 ARID1A EP300	1.46e-03	277	88	5	C0009404
Disease	autosomal dominant compelling helio-ophthalmic outburst syndrome	SH3RF1 KIF2B ZFHX3	1.60e-03	77	88	3	EFO_0007887
Disease	e-selectin measurement	LINC02908 CELSR2	1.95e-03	22	88	2	EFO_0004575
Disease	Granulomatous Slack Skin	NFKB2 ARID1A	1.95e-03	22	88	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	NFKB2 ARID1A	2.14e-03	23	88	2	C0079773
Disease	uric acid measurement	TET2 PRKD2 FBRSL1 VAX2 MLXIP ARID1A CNTROB	2.33e-03	610	88	7	EFO_0004761
Disease	Prostatic Neoplasms	TET2 KMT2D HDAC6 CDK12 ZFHX3 ARID1A CNOT3	2.47e-03	616	88	7	C0033578
Disease	Malignant neoplasm of prostate	TET2 KMT2D HDAC6 CDK12 ZFHX3 ARID1A CNOT3	2.47e-03	616	88	7	C0376358
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	KLHL29 TET2 PHOX2A KIF2B FEZF1 MTFR1 ZFHX3 FIGN	2.71e-03	801	88	8	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	Kallmann Syndrome	FEZF1 CCDC141	2.73e-03	26	88	2	C0162809
Disease	smoking cessation	KLHL29 CDK12 ZFHX3 CCDC141 ZNF804A	2.92e-03	325	88	5	EFO_0004319

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSPPPLSGQPSLQPP	NT5C1B	166	Q96P26
TPTAPLLPPQPATPL	EP300	926	Q09472
LPPPPALPASSLVLP	FBRSL1	386	Q9HCM7
TLPLALPGAPAPLPP	MLLT6	846	P55198
ALLPGPPAPSPLPAT	ARHGEF18	1331	Q6ZSZ5
TLPPLPLPPLLPGDD	CDK12	626	Q9NYV4
TSPEPELLPGAPLPP	EIF3G	41	O75821
PGLIPPPLAPISGPL	CTAGE4	691	Q8IX94
PGLIPPPLAPISGPL	CTAGE9	691	A4FU28
PGLSDPLPLPPGTLP	CD300LD-AS1	226	Q96MU5
LPPPLPTMPTLTSLP	ANGPTL2	251	Q9UKU9
TGVPLPTPPPPLLLL	CELSR2	6	Q9HCU4
LLPLEPPLPPGTLPQ	ATF5	76	Q9Y2D1
LLVPLPVNPPSSPTP	CNOT3	496	O75175
LLTPLPPSALPSAPP	NPIPB3	346	Q92617
LLLLPPPGSPEPPGL	P3H3	11	Q8IVL6
SSLGNPPPPPPSELK	ARID1A	11	O14497
PSPLHSSGLLQPPPP	FIGN	211	Q5HY92
ALTPPPLPPSNNLPA	MBD6	266	Q96DN6
LPLPLSLGQPPPSPL	MBD6	541	Q96DN6
LSLLGTPPAPPPAPA	GPR62	146	Q9BZJ7
LPPSAAPTGPLLAPP	MALT1	11	Q9UDY8
PAPPLSPALSGLPRP	MYO15A	676	Q9UKN7
LPSLPLTRAPVPPGP	GDF1	21	P27539
GSLSTNPEPLPPPLP	PEAK3	46	Q6ZS72
PGPPALPLLKASFPP	GSX1	71	Q9H4S2
PGSLPLLDPNASPPP	MEX3D	121	Q86XN8
PPPGGLELQSPPPLL	PRKD2	21	Q9BZL6
PPLLSPVLIPSPSPS	KRTAP4-16	191	G5E9R7
SPSPSPSLPSLSPPL	KRTAP4-16	201	G5E9R7
LLTPLPPSALPSAPP	NPIPB5	346	A8MRT5
PTPLPVAPPLTPGLG	GGN	456	Q86UU5
LLTPLPPSALPSAPP	NPIPB4	346	C9JG80
SLLLPPASSPPPPQV	HCN4	1051	Q9Y3Q4
ALLAGDPSQPPPPPL	OBSCN	5811	Q5VST9
PPPLPPPALGLHQST	MTFR1	191	Q15390
PSLLPPLGLSQSGPP	POM121	631	Q96HA1
LLSPSPAPPPISPVL	MLXIP	436	Q9HAP2
SLLASLTPPPLPPPD	CNPPD1	311	Q9BV87
LAPAPLPAGLPPLAP	GBX1	61	Q14549
LPPLPGSPESPLAPS	CCDC141	1216	Q6ZP82
LPPSPLPLAAGDPLP	GFRA3	21	O60609
CSGPLLPPPSSQPLP	FAM193B	341	Q96PV7
PPPPSAPSLLLEDPG	LINC02908	116	Q6ZV77
SLGPPAPPALPPLQG	KANK4	181	Q5T7N3
LTPGLPAPTPLPAPA	FIGNL2	231	A6NMB9
DPPPLLTLPRPPLSG	HDAC6	801	Q9UBN7
LPGVASFTPPLPPPL	ETV3L	226	Q6ZN32
TDHPLPPLPSPLLPT	RTL8C	116	O15255
SLPPPPLQPPSLPLS	PPRC1	891	Q5VV67
QLLSTTLPPPNPPAP	CNTROB	566	Q8N137
PPPPLSPLALAPSSA	KIF2B	91	Q8N4N8
PPPLPSAPLLELPEG	ITPRIPL2	326	Q3MIP1
PPPPPAANLLLLGPS	NYAP1	386	Q6ZVC0
PQPQSLPLPPSLPSA	PHETA1	141	Q8N4B1
LPLPPSLPSALAPVP	PHETA1	146	Q8N4B1
SLPSAPAPVPALPLP	PHETA1	161	Q8N4B1
LPSLPTPPASTLPGP	SSPOP	1531	A2VEC9
PPQLSSPPALPQSPL	PIWIL2	181	Q8TC59
LQPPLPTPGPLQPGL	FEZF1	456	A0PJY2
LATPLPLAPPSPSAP	PRR36	366	Q9H6K5
ASPPLQGLPSPPLSP	PRR36	821	Q9H6K5
QGLPSPPLSPLATPP	PRR36	826	Q9H6K5
PPALATPPLQALPSP	PRR36	1011	Q9H6K5
APTPLPPLLPAPLAS	SETD1B	1496	Q9UPS6
APNTLLPAPPSGPPI	PRRC1	116	Q96M27
VPLSPLPGPKQTPPL	TDRD7	316	Q8NHU6
PPLYQAGLTPPLSPP	PRR12	1296	Q9ULL5
SPAPPLAPLPVLAPS	SRCAP	1601	Q6ZRS2
PIPSLSLPPSPGPQA	PROB1	946	E7EW31
PLPPPPLLPPSLTNG	MRTFA	181	Q969V6
PLLPSLPPLGPSPLC	STRC	576	Q7RTU9
LPPLGPSPLCLTPGP	STRC	581	Q7RTU9
ALGTLNPPLPPPPLL	SH3RF1	391	Q7Z6J0
PPPLSPLGGPVPSAL	TRIP10	331	Q15642
PAPSPGLKLEPPLTP	C15orf39	351	Q6ZRI6
PLTPLPVGLQPPSLP	TLE5	141	Q08117
LPLTPPSPSLSPSPL	PHF21B	211	Q96EK2
ATKSGLLPPPPALPP	REPS2	506	Q8NFH8
SLPPPPAPGLASPRL	PHOX2A	191	O14813
SPLSPLNPLGPPTPL	PRRG2	151	O14669
LPLLPAPPPGSVRLP	USF3	591	Q68DE3
AAPPSPLPGPGPLLQ	IGSF9	911	Q9P2J2
PTLPPVLLSSSPPGP	SNX19	496	Q92543
SSSPALLLSPPPPGL	SIX2	226	Q9NPC8
LPGAVPPPLPSALPA	TLX3	96	O43711
LPPPSLSSAGPPPVL	YLPM1	591	P49750
LSSAGPPPVLPPPSL	YLPM1	596	P49750
ALPTVLTPLAPPGPP	VWA5B2	151	Q8N398
PLSSASASPPLPPPL	VAX2	231	Q9UIW0
PLLPSLPPLGPSPLC	STRCP1	576	A6NGW2
LPPLGPSPLCLTPGP	STRCP1	581	A6NGW2
PPPPPLPSALSTSSL	WASF1	326	Q92558
PSLAAPLPPASPALP	WNK2	841	Q9Y3S1
APESSPPLPLSSLPP	WNK2	1326	Q9Y3S1
PSQLLLSPPPPLPQV	TET2	401	Q6N021
LSLPPPPQVSSLPPL	ZFC3H1	566	O60293
PGLLSQSPPAPPSPL	WNK4	946	Q96J92
QSPPAPPSPLPSLPL	WNK4	951	Q96J92
LPGPLSTPVPELPGP	SON	416	P18583
AALPLPLSLAPPPLP	ZBTB22	11	O15209
GSTPSPLSSLLPPPP	ZC3H13	1091	Q5T200
PLSSLLPPPPPVATA	ZC3H13	1096	Q5T200
LPQLVSLPSLPQPPP	ZFHX3	2471	Q15911
PAALPPPSTPLQPLP	ZNF804A	1071	Q7Z570
LLPPPPPAQPSATLP	KLHL29	261	Q96CT2
PLFPPPGEPSLSPLL	KMT2D	881	O14686
GLSPLRPPSVLPPPA	KMT2D	2606	O14686
PLLPGTPVDSLPPPL	MYPOP	296	Q86VE0
PPLTPPSPAGPGLSL	NFKB2	756	Q00653