Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	maintenance of centrosome location	ASPM GPSM2	4.18e-05	6	35	2	GO:0051661
GeneOntologyBiologicalProcess	T cell activation involved in immune response	KMT2A RARA IFNA6 IFNA14	1.12e-04	148	35	4	GO:0002286
GeneOntologyBiologicalProcess	peptidyl-lysine monomethylation	KMT2A CSKMT	1.52e-04	11	35	2	GO:0018026
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	ASPM GPSM2 KIF3B TTLL3 BRSK1 DNAH5 SON	1.76e-04	720	35	7	GO:0000226
GeneOntologyBiologicalProcess	peptidyl-amino acid modification	KMT2A CSKMT GALNT6 SLF1 TTLL3 BRSK1 IFNA6 IFNA14	1.84e-04	976	35	8	GO:0018193
GeneOntologyBiologicalProcess	maintenance of organelle location	ASPM GPSM2	2.16e-04	13	35	2	GO:0051657
HumanPheno	Broad lateral eyebrow	KMT2A SON	1.80e-05	3	13	2	HP:0007933
HumanPheno	Broad eyebrow	KMT2A HERC1 SON	4.57e-05	29	13	3	HP:0011229
HumanPheno	Hyperextensibility at elbow	KMT2A SON	8.97e-05	6	13	2	HP:0010485
Domain	Interferon_alpha/beta/delta	IFNA6 IFNA14	4.82e-04	17	36	2	IPR000471
Domain	Interferon	IFNA6 IFNA14	4.82e-04	17	36	2	PF00143
Domain	IFabd	IFNA6 IFNA14	4.82e-04	17	36	2	SM00076
Domain	INTERFERON_A_B_D	IFNA6 IFNA14	4.82e-04	17	36	2	PS00252
Domain	-	IFNA6 IFNA14	4.18e-03	50	36	2	1.20.1250.10
Domain	4_helix_cytokine_core	IFNA6 IFNA14	4.34e-03	51	36	2	IPR012351
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_TAT_TO_TLR2_4_NFKB_SIGNALING_PATHWAY	IFNA6 IFNA14	4.04e-04	17	25	2	M47564
Pathway	KEGG_MEDICUS_REFERENCE_CGAS_STING_SIGNALING_PATHWAY	IFNA6 IFNA14	4.54e-04	18	25	2	M47539
Pathway	BIOCARTA_IFNA_PATHWAY	IFNA6 IFNA14	5.07e-04	19	25	2	MM1571
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY	IFNA6 IFNA14	5.07e-04	19	25	2	M47450
Pathway	KEGG_MEDICUS_REFERENCE_TLR7_9_IRF7_SIGNALING_PATHWAY	IFNA6 IFNA14	5.63e-04	20	25	2	M47617
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_II_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	IFNA6 IFNA14	6.21e-04	21	25	2	M47909
Pathway	KEGG_MEDICUS_REFERENCE_TLR7_8_9_IRF5_SIGNALING_PATHWAY	IFNA6 IFNA14	6.82e-04	22	25	2	M47897
Pathway	KEGG_MEDICUS_REFERENCE_RIG_I_NFKB_SIGNALING_PATHWAY	IFNA6 IFNA14	6.82e-04	22	25	2	M47616
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	IFNA6 IFNA14	7.47e-04	23	25	2	MM15634
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_IFN_SIGNALING_PATHWAY	IFNA6 IFNA14	7.47e-04	23	25	2	M47452
Pathway	KEGG_MEDICUS_REFERENCE_MDA5_IRF7_3_SIGNALING_PATHWAY	IFNA6 IFNA14	8.14e-04	24	25	2	M47782
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	IFNA6 IFNA14	8.14e-04	24	25	2	M47908
Pathway	KEGG_MEDICUS_REFERENCE_RIG_I_IRF7_3_SIGNALING_PATHWAY	IFNA6 IFNA14	8.14e-04	24	25	2	M47576
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	IFNA6 IFNA14	9.56e-04	26	25	2	M982
Pathway	BIOCARTA_CYTOKINE_PATHWAY	IFNA6 IFNA14	1.11e-03	28	25	2	MM1378
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION	IFNA6 IFNA14	1.27e-03	30	25	2	M936
Pathway	KEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY	IFNA6 IFNA14	1.36e-03	31	25	2	M47964
Pathway	WP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY	IFNA6 IFNA14	1.36e-03	31	25	2	M39897
Pathway	BIOCARTA_INFLAM_PATHWAY	IFNA6 IFNA14	1.54e-03	33	25	2	MM1379
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	IFNA6 IFNA14	1.64e-03	34	25	2	MM15631
Pathway	KEGG_REGULATION_OF_AUTOPHAGY	IFNA6 IFNA14	1.73e-03	35	25	2	M6382
Pathway	REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES	IFNA6 IFNA14	1.73e-03	35	25	2	M48246
Pathway	WP_INTERFERONMEDIATED_SIGNALING	IFNA6 IFNA14	1.94e-03	37	25	2	M39785
Pathway	WP_CYTOKINES_AND_INFLAMMATORY_RESPONSE	IFNA6 IFNA14	2.15e-03	39	25	2	MM15914
Pathway	BIOCARTA_IL1R_PATHWAY	IFNA6 IFNA14	2.37e-03	41	25	2	MM1493
Pathway	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	KIF3B IFNA6 IFNA14	3.26e-03	170	25	3	M941
Pathway	KEGG_AUTOIMMUNE_THYROID_DISEASE	IFNA6 IFNA14	3.79e-03	52	25	2	M13103
Pathway	KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY	IFNA6 IFNA14	4.23e-03	55	25	2	M11844
Pubmed	Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.	RHOXF2B RHOXF2	1.10e-06	2	37	2	12087094
Pubmed	Rhox homeobox gene cluster: recent duplication of three family members.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16496311
Pubmed	Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16465597
Pubmed	Cloning and characterization of the 5'-flanking region of the Ehox gene.	RHOXF2B RHOXF2	1.10e-06	2	37	2	16414020
Pubmed	The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.	RHOXF2B RHOXF2	3.30e-06	3	37	2	18077458
Pubmed	SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.	KMT2A SON	3.30e-06	3	37	2	26990989
Pubmed	The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development.	RHOXF2B RHOXF2	3.30e-06	3	37	2	18562707
Pubmed	Rhox: a new homeobox gene cluster.	RHOXF2B RHOXF2	6.60e-06	4	37	2	15707895
Pubmed	Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.	RHOXF2B RHOXF2	1.10e-05	5	37	2	14648851
Pubmed	Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.	RHOXF2B RHOXF2	4.93e-05	10	37	2	21972064
Pubmed	Effect of interferon-alpha on immediate early gene expression of murine cytomegalovirus.	IFNA6 IFNA14	6.02e-05	11	37	2	8389790
Pubmed	Type I interferon dependence of plasmacytoid dendritic cell activation and migration.	IFNA6 IFNA14	6.02e-05	11	37	2	15795237
Pubmed	Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.	IFNA6 IFNA14	6.02e-05	11	37	2	9794439
Pubmed	Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis.	IFNA6 IFNA14	6.02e-05	11	37	2	18835032
Pubmed	Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha.	IFNA6 IFNA14	6.02e-05	11	37	2	10448195
Pubmed	High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptor.	IFNA6 IFNA14	6.02e-05	11	37	2	6444699
Pubmed	Recombinant rabies virus expressing IFNα1 enhanced immune responses resulting in its attenuation and stronger immunogenicity.	IFNA6 IFNA14	6.02e-05	11	37	2	25310498
Pubmed	The mouse IFN-alpha (Ifa) locus: correlation of physical and linkage maps by in situ hybridization.	IFNA6 IFNA14	6.02e-05	11	37	2	3456887
Pubmed	IFN-alpha can both protect against and promote the development of type 1 diabetes.	IFNA6 IFNA14	6.02e-05	11	37	2	19120292
Pubmed	Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression.	IFNA6 IFNA14	6.02e-05	11	37	2	36681180
Pubmed	Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).	IFNA6 IFNA14	7.22e-05	12	37	2	16565497
Pubmed	AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis.	IFNA6 IFNA14	7.22e-05	12	37	2	22685550
Pubmed	Sequence and expression of a novel murine interferon alpha gene--homology with enhancer elements in the regulatory region of the gene.	IFNA6 IFNA14	7.22e-05	12	37	2	3017340
Pubmed	Mapping of murine interferon-alpha genes to chromosome 4.	IFNA6 IFNA14	7.22e-05	12	37	2	6689487
Pubmed	Regulation of effector and memory T-cell functions by type I interferon.	IFNA6 IFNA14	7.22e-05	12	37	2	21320124
Pubmed	MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.	IFNA6 IFNA14	7.22e-05	12	37	2	33123150
Pubmed	Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus.	IFNA6 IFNA14	7.22e-05	12	37	2	20038206
Pubmed	Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice.	IFNA6 IFNA14	7.22e-05	12	37	2	18716002
Pubmed	Murine alpha/beta interferons inhibit benzo(a)pyrene activation and mutagenesis in mice.	IFNA6 IFNA14	7.22e-05	12	37	2	8304945
Pubmed	Characterization of murine interferon-alpha 12 (MuIFN-alpha12): biological activities and gene expression.	IFNA6 IFNA14	7.22e-05	12	37	2	17451966
Pubmed	The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoter.	IFNA6 IFNA14	7.22e-05	12	37	2	11846978
Pubmed	A major X-linked locus affects kidney function in mice.	RHOXF2B RHOXF2	7.22e-05	12	37	2	23011808
Pubmed	Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes.	IFNA6 IFNA14	7.22e-05	12	37	2	25897172
Pubmed	A novel anti-viral role for STAT3 in IFN-α signalling responses.	IFNA6 IFNA14	7.22e-05	12	37	2	27988795
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	RHOXF2B RHOXF2	7.22e-05	12	37	2	29500366
Pubmed	Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway.	IFNA6 IFNA14	7.22e-05	12	37	2	16611902
Pubmed	Obesity worsens the outcome of influenza virus infection associated with impaired type I interferon induction in mice.	IFNA6 IFNA14	7.22e-05	12	37	2	30967261
Pubmed	Identification of distal silencing elements in the murine interferon-A11 gene promoter.	IFNA6 IFNA14	7.22e-05	12	37	2	8760352
Pubmed	Evolution of the interferon alpha gene family in eutherian mammals.	IFNA6 IFNA14	7.22e-05	12	37	2	17512142
Pubmed	A polymorphic trinucleotide repeat sequence mapping to distal mouse chromosome 4.	IFNA6 IFNA14	7.22e-05	12	37	2	8672140
Pubmed	Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.	IFNA6 IFNA14	7.22e-05	12	37	2	9425112
Pubmed	IFN-alpha-mediated suppression of low-affinity FC(epsilon) receptors on Peyer's patch lymphocytes and augmentation of soluble CD23: implications for IgE responses.	IFNA6 IFNA14	7.22e-05	12	37	2	8656058
Pubmed	Repression of the murine interferon alpha 11 gene: identification of negatively acting sequences.	IFNA6 IFNA14	7.22e-05	12	37	2	1886773
Pubmed	Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.	IFNA6 IFNA14	7.22e-05	12	37	2	22912583
Pubmed	The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration.	IFNA6 IFNA14	7.22e-05	12	37	2	23747509
Pubmed	Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice.	IFNA6 IFNA14	7.22e-05	12	37	2	17434974
Pubmed	Behavioral effects of mouse interferons-alpha and -gamma and human interferon-alpha in mice.	IFNA6 IFNA14	7.22e-05	12	37	2	1422836
Pubmed	Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.	IFNA6 IFNA14	7.22e-05	12	37	2	18937499
Pubmed	The physical separation of Lps and Ifa loci in BXH recombinant inbred mice.	IFNA6 IFNA14	7.22e-05	12	37	2	2572648
Pubmed	Structure and expression of a new murine interferon-alpha gene: MuIFN-alpha I9.	IFNA6 IFNA14	7.22e-05	12	37	2	3758677
Pubmed	Developmental control of IFN-alpha expression in murine embryos.	IFNA6 IFNA14	7.22e-05	12	37	2	7925651
Pubmed	The role of type 1 interferons in coagulation induced by gram-negative bacteria.	IFNA6 IFNA14	7.22e-05	12	37	2	32016282
Pubmed	Role of interferons in the regulation of cell proliferation, differentiation, and development.	IFNA6 IFNA14	7.22e-05	12	37	2	7530016
Pubmed	Interferon-alpha/beta can impede development of carcinogen-induced squamous-cell tumors in the esophagus of C57B1 mice.	IFNA6 IFNA14	7.22e-05	12	37	2	7601556
Pubmed	Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs.	IFNA6 IFNA14	7.22e-05	12	37	2	17277125
Pubmed	Nonviral interferon alpha gene therapy inhibits growth of established tumors by eliciting a systemic immune response.	IFNA6 IFNA14	7.22e-05	12	37	2	9794206
Pubmed	Multiple pathways of interferon-induced gene expression in murine macrophages.	IFNA6 IFNA14	7.22e-05	12	37	2	7684767
Pubmed	Isolation and mapping of four new DNA markers from mouse chromosome 4.	IFNA6 IFNA14	7.22e-05	12	37	2	1360280
Pubmed	Structure and expression of cloned murine IFN-alpha genes.	IFNA6 IFNA14	7.22e-05	12	37	2	6188104
Pubmed	Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.	IFNA6 IFNA14	7.22e-05	12	37	2	26277892
Pubmed	GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.	IFNA6 IFNA14	7.22e-05	12	37	2	19406830
Pubmed	Mapping the genetic region coding for herpes simplex virus resistance to mouse interferon alpha/beta.	IFNA6 IFNA14	7.22e-05	12	37	2	8245849
Pubmed	Isolation and characterization of a functional murine interferon alpha gene which is not expressed in fibroblasts upon virus induction.	IFNA6 IFNA14	8.53e-05	13	37	2	2471809
Pubmed	HIV-1 Gag-virus-like particles inhibit HIV-1 replication in dendritic cells and T cells through IFN-α-dependent upregulation of APOBEC3G and 3F.	IFNA6 IFNA14	8.53e-05	13	37	2	22739040
Pubmed	IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.	IFNA6 IFNA14	8.53e-05	13	37	2	21263073
Pubmed	Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells.	IFNA6 IFNA14	8.53e-05	13	37	2	8438572
Pubmed	Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1.	IFNA6 IFNA14	8.53e-05	13	37	2	38660315
Pubmed	Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro.	IFNA6 IFNA14	8.53e-05	13	37	2	9343822
Pubmed	Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.	IFNA6 IFNA14	8.53e-05	13	37	2	20065291
Pubmed	Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype.	IFNA6 IFNA14	8.53e-05	13	37	2	12930842
Pubmed	Effects of IFN alpha on late stages of HIV-1 replication cycle.	IFNA6 IFNA14	8.53e-05	13	37	2	9865497
Pubmed	Cutting edge: IL-12 and type I IFN differentially program CD8 T cells for programmed death 1 re-expression levels and tumor control.	IFNA6 IFNA14	8.53e-05	13	37	2	23804712
Pubmed	Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.	IFNA6 IFNA14	8.53e-05	13	37	2	9181467
Pubmed	Evidence for a different susceptibility of primate lentiviruses to type I interferons.	IFNA6 IFNA14	8.53e-05	13	37	2	23255800
Pubmed	Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.	IFNA6 IFNA14	8.53e-05	13	37	2	22431588
Pubmed	Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.	IFNA6 IFNA14	8.53e-05	13	37	2	17723216
Pubmed	Mouse interferon alpha and beta genes are linked at the centromere proximal region of chromosome 4.	IFNA6 IFNA14	8.53e-05	13	37	2	3973562
Pubmed	Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.	IFNA6 IFNA14	8.53e-05	13	37	2	2014240
Pubmed	Distinction of mouse interferon-alpha subtypes by polymerase chain reaction utilizing consensus primers and type-specific oligonucleotide probes.	IFNA6 IFNA14	8.53e-05	13	37	2	7523540
Pubmed	Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.	IFNA6 IFNA14	8.53e-05	13	37	2	7510216
Pubmed	An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein.	IFNA6 IFNA14	8.53e-05	13	37	2	18005734
Pubmed	Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication.	IFNA6 IFNA14	8.53e-05	13	37	2	12050368
Pubmed	Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.	IFNA6 IFNA14	8.53e-05	13	37	2	19635904
Pubmed	Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5.	IFNA6 IFNA14	8.53e-05	13	37	2	20427526
Pubmed	Sequencing and bacterial expression of a novel murine alpha interferon gene.	IFNA6 IFNA14	8.53e-05	13	37	2	18726328
Pubmed	Partial inhibition of human immunodeficiency virus replication by type I interferons: impact of cell-to-cell viral transfer.	IFNA6 IFNA14	8.53e-05	13	37	2	19706714
Pubmed	Organization, structure and expression of murine interferon alpha genes.	IFNA6 IFNA14	8.53e-05	13	37	2	2987810
Pubmed	Isolation and bacterial expression of a murine alpha leukocyte interferon gene.	IFNA6 IFNA14	8.53e-05	13	37	2	6094686
Pubmed	Segregation of restriction fragment length polymorphism in an interspecies cross of laboratory and wild mice indicates tight linkage of the murine IFN-beta gene to the murine IFN-alpha genes.	IFNA6 IFNA14	8.53e-05	13	37	2	2993652
Pubmed	Anti-retroviral effects of type I IFN subtypes in vivo.	IFNA6 IFNA14	8.53e-05	13	37	2	19130550
Pubmed	Isolation and characterization of a novel interferon-alpha-encoding gene, IFN-alpha 11, within a murine IFN cluster.	IFNA6 IFNA14	8.53e-05	13	37	2	1655578
Pubmed	Distinct signature type I interferon responses are determined by the infecting virus and the target cell.	IFNA6 IFNA14	8.53e-05	13	37	2	18572754
Pubmed	Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.	IFNA6 IFNA14	8.53e-05	13	37	2	15723075
Pubmed	Type I IFN protects against antigen-induced arthritis.	IFNA6 IFNA14	8.53e-05	13	37	2	21469099
Pubmed	Differential constitutive expression of interferon genes in early mouse embryos.	IFNA6 IFNA14	9.94e-05	14	37	2	7654369
Pubmed	Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.	IFNA6 IFNA14	9.94e-05	14	37	2	2552026
Pubmed	Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.	IFNA6 IFNA14	9.94e-05	14	37	2	14983024
Pubmed	Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.	IFNA6 IFNA14	9.94e-05	14	37	2	22815848
Pubmed	Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7.	IFNA6 IFNA14	9.94e-05	14	37	2	22095711
Pubmed	Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling.	IFNA6 IFNA14	9.94e-05	14	37	2	18981154
Cytoband	9p22	IFNA6 IFNA14	1.87e-04	25	37	2	9p22
Cytoband	Xq24	RHOXF2B RHOXF2	1.23e-03	64	37	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	RHOXF2B RHOXF2	1.97e-03	81	37	2	chrXq24
GeneFamily	Interferons	IFNA6 IFNA14	9.61e-04	32	26	2	598
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC45A2 WAPL SLF1 ARMH3	8.19e-06	155	37	4	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC5 SLITRK3 SLF1 TTLL3	9.99e-06	163	37	4	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	SLC45A2 DEPDC5 PDZD7 FAM81A	1.13e-05	168	37	4	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC45A2 WAPL SLF1 ARMH3	1.21e-05	171	37	4	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TRIM15 GALNT6 HERC1 ZUP1	1.64e-05	185	37	4	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
Disease	hair colour measurement, hair morphology measurement	MRPL13 SLC45A2	7.95e-05	12	33	2	EFO_0007821, EFO_0007822
Disease	phosphatidylcholine 38:6 measurement	DEPDC5 FASTKD2	1.44e-04	16	33	2	EFO_0010388
Disease	resting heart rate, chronic obstructive pulmonary disease	HERC1 CASZ1	5.17e-04	30	33	2	EFO_0000341, EFO_0004351
Disease	Paroxysmal atrial fibrillation	HERC1 ARMH3 CASZ1	7.04e-04	156	33	3	C0235480
Disease	Persistent atrial fibrillation	HERC1 ARMH3 CASZ1	7.04e-04	156	33	3	C2585653
Disease	familial atrial fibrillation	HERC1 ARMH3 CASZ1	7.04e-04	156	33	3	C3468561
Disease	Atrial Fibrillation	HERC1 ARMH3 CASZ1	7.58e-04	160	33	3	C0004238
Disease	age at onset, alcohol dependence	FAM81A CASZ1	1.02e-03	42	33	2	EFO_0004847, MONDO_0007079
Disease	Malignant neoplasm of salivary gland	ASPM SON	1.17e-03	45	33	2	C0220636
Disease	Salivary Gland Neoplasms	ASPM SON	1.27e-03	47	33	2	C0036095
Disease	Liver carcinoma	ASPM KMT2A DEPDC5 RARA	2.37e-03	507	33	4	C2239176
Disease	congenital heart disease (implicated_via_orthology)	KMT2A SON	2.72e-03	69	33	2	DOID:1682 (implicated_via_orthology)
Disease	skin pigmentation	SLC45A2 TTLL3	2.72e-03	69	33	2	EFO_0003784

Protein segments in the cluster

Peptide	Gene	Start	Entry
QMTSHARKHMRRMLG	CASZ1	1316	Q86V15
MNFRVNLHRMPMRHR	ARMH3	416	Q5T2E6
MIRKRMREMHRAATF	ASPM	2326	Q8IZT6
RRPSRPHMFPKMLMK	RARA	366	P10276
MENMHLRRVRTMPRH	FAM81A	1	Q8TBF8
RSDRMMRKGTAMKGL	DEPDC5	1001	O75140
RTLMLMAQMRRISPF	IFNA14	36	P01570
PKLGRRHSMENMELM	GPSM2	401	P81274
LGPRGMLGRMMRRFH	GLTPD2	76	A6NH11
MLGRMMRRFHASLKP	GLTPD2	81	A6NH11
SPETRLRFMRAMHGM	ASMTL	421	O95671
LRFMRAMHGMTKLTA	ASMTL	426	O95671
LMRHMVKRAVMRSPI	HERC1	2566	Q15751
SSRLHMMVRRMGRVP	PDZD7	156	Q9H5P4
MAALRRMLHLPSLMM	CSKMT	1	A8MUP2
MRLLRRRHMPLRLAM	GALNT6	1	Q8NCL4
MLSRHGKRRPERKSM	BRSK1	386	Q8TDC3
ARRATSMDLPMPMRF	KMT2A	3806	Q03164
SMDLPMPMRFRHLKK	KMT2A	3811	Q03164
PTSRLIMHSMAMFGR	SLC45A2	31	Q9UMX9
MRAMTDCGKPHREMR	DNAH5	2276	Q8TE73
SLGHRRTMMLLAQMR	IFNA6	31	P05013
SLRRSLRMGFMTMPA	NYAP1	51	Q6ZVC0
MAALLMPRRNKGMRT	RGS8	1	P57771
HIMSRSPMVERRMMG	SYNPO	531	Q8N3V7
PRGFLAMKMRHLNAM	FASTKD2	651	Q9NYY8
MKPSIAEMLHRGRML	SLITRK3	1	O94933
TLAGRRGMRPKMMMP	NEO1	1226	Q92859
MPMVGRMSTQERLKH	PPP1R16A	11	Q96I34
RHQRALMARNMLPFM	RHOXF2B	191	P0C7M4
KRPLSQHARMSMMIR	KIF3B	636	O15066
DFHRKILTLPEMMRM	TRIM15	266	Q9C019
AMPSFRMHLRAHGMV	WAPL	686	Q7Z5K2
RHQRALMARNMLPFM	RHOXF2	191	Q9BQY4
FTIKKPMAMCHRRMG	TTLL3	536	Q9Y4R7
IFLGLKMGRNVMRHM	SLF1	631	Q9BQI6
MLPKNLHRRTMMERL	MRPL13	111	Q9BYD1
FQRHMKMHTRMRPYK	ZNF844	351	Q08AG5
RMPPSEFHRRKADMM	ZUP1	291	Q96AP4
LAPRPLMLASRRSMM	SON	986	P18583