Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	PGA4 PGA5 PGA3	1.66e-05	37	27	3	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	PGA4 PGA5 PGA3	1.80e-05	38	27	3	GO:0070001
GeneOntologyCellularComponent	multivesicular body lumen	PGA4 PGA5 PGA3	6.70e-08	7	27	3	GO:0097486
GeneOntologyCellularComponent	late endosome lumen	PGA4 PGA5 PGA3	3.15e-07	11	27	3	GO:0031906
GeneOntologyCellularComponent	endosome lumen	PGA4 PGA5 PGA3	2.29e-05	43	27	3	GO:0031904
GeneOntologyCellularComponent	multivesicular body	PGA4 PGA5 PGA3	1.96e-04	88	27	3	GO:0005771
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	OSBPL2 OSBPL1A	6.38e-04	29	27	2	GO:0097038
GeneOntologyCellularComponent	late endosome	PGA4 PGA5 PGA3 OSBPL1A	9.79e-04	348	27	4	GO:0005770
Domain	Aspartic_peptidase_N	PGA4 PGA5 PGA3	8.35e-08	7	26	3	IPR012848
Domain	A1_Propeptide	PGA4 PGA5 PGA3	8.35e-08	7	26	3	PF07966
Domain	Aspartic_peptidase_A1	PGA4 PGA5 PGA3	2.86e-07	10	26	3	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	2.86e-07	10	26	3	IPR033121
Domain	Asp	PGA4 PGA5 PGA3	2.86e-07	10	26	3	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	2.86e-07	10	26	3	PS51767
Domain	-	PGA4 PGA5 PGA3	5.22e-07	12	26	3	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5 PGA3	5.22e-07	12	26	3	PS00141
Domain	Aspartic_peptidase_AS	PGA4 PGA5 PGA3	6.79e-07	13	26	3	IPR001969
Domain	Peptidase_aspartic_dom	PGA4 PGA5 PGA3	1.61e-06	17	26	3	IPR021109
Domain	Oxysterol_BP	OSBPL2 OSBPL1A	1.22e-04	12	26	2	PF01237
Domain	Oxysterol-bd	OSBPL2 OSBPL1A	1.22e-04	12	26	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL2 OSBPL1A	1.22e-04	12	26	2	IPR018494
Domain	OSBP	OSBPL2 OSBPL1A	1.22e-04	12	26	2	PS01013
Domain	Znf_PHD-finger	KMT2D NFX1	5.38e-03	79	26	2	IPR019787
Domain	EGF	CNTNAP4 NOTCH1	1.32e-02	126	26	2	PF00008
Pathway	WP_GASTRIC_ACID_PRODUCTION	PGA4 PGA5 PGA3	3.40e-07	11	19	3	M39726
Pathway	REACTOME_SURFACTANT_METABOLISM	PGA4 PGA5 PGA3	8.24e-06	30	19	3	M27566
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH1 NFX1	1.33e-04	13	19	2	M47534
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	OSBPL2 OSBPL1A	8.86e-04	33	19	2	M5967
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	OSBPL2 OSBPL1A	8.86e-04	33	19	2	MM14737
Pubmed	Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2032552
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3017318
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	21989121
Pubmed	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8053437
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	9855083
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2478370
Pubmed	Analysis of the promoter of a human pepsinogen A gene.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	1812762
Pubmed	O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	7923573
Pubmed	Family and population studies on the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2566575
Pubmed	Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	9061458
Pubmed	Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	12588289
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3815274
Pubmed	Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2229438
Pubmed	Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	25314140
Pubmed	Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	19890696
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	10675278
Pubmed	Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	23897256
Pubmed	An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	11566730
Pubmed	The effect of acute and chronic protein loading on urinary pepsinogen A excretion.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	1956484
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	7926498
Pubmed	Transcription regulation of human and porcine pepsinogen A.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8540382
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3780036
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	9561228
Pubmed	Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8244094
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	21455714
Pubmed	Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	21407214
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	19800305
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2901984
Pubmed	Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	22992016
Pubmed	The role of serum pepsinogen in the detection of gastric cancer.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	20981206
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3839486
Pubmed	Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	6774973
Pubmed	Gastric chief cell-specific transcription of the pepsinogen A gene.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8504820
Pubmed	Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	21970995
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	24170207
Pubmed	Primary structure of human pepsinogen gene.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	6300126
Pubmed	Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	22304859
Pubmed	Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	24004680
Pubmed	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8038355
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3467902
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	4586732
Pubmed	Serum pepsinogens in gastric cancer screening.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	20428942
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3014868
Pubmed	Human pepsinogen A isozymogen patterns in serum and gastric mucosa.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2227273
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2892778
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	24383519
Pubmed	The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	9525001
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	1455184
Pubmed	Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	7886402
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2831884
Pubmed	Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	23034090
Pubmed	A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	24125879
Pubmed	Serum pepsinogen and gastric cancer screening.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	17379991
Pubmed	Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	8751234
Pubmed	Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	3554488
Pubmed	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	2799289
Pubmed	CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	19872561
Pubmed	Human pepsinogen A (PGA): an informative gene complex located at 11q13.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	1968039
Pubmed	Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	21547904
Pubmed	Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.	PGA4 PGA5 PGA3	4.17e-10	3	27	3	23521833
Pubmed	Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.	PGA4 PGA5 PGA3	1.67e-09	4	27	3	23047493
Pubmed	Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.	PGA4 PGA5 PGA3	1.67e-09	4	27	3	8322031
Pubmed	Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.	PGA4 PGA5 PGA3	1.67e-09	4	27	3	17136346
Pubmed	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PGA4 PGA5 PGA3	1.67e-09	4	27	3	12698190
Pubmed	Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.	PGA4 PGA5 PGA3	1.67e-09	4	27	3	11915945
Pubmed	Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.	PGA4 PGA5 PGA3	4.17e-09	5	27	3	22066020
Pubmed	Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.	PGA4 PGA5 PGA3	3.38e-07	18	27	3	36057966
Pubmed	Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.	NOTCH1 NFX1	5.80e-07	2	27	2	25723053
Pubmed	Crystal structure of human pepsin and its complex with pepstatin.	PGA4 PGA5	5.80e-07	2	27	2	7663352
Pubmed	Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.	OSBPL2 OSBPL1A	5.80e-07	2	27	2	11279184
Pubmed	NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.	NOTCH1 NFX1	5.80e-07	2	27	2	24109236
Pubmed	Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.	PGA4 PGA5	5.80e-07	2	27	2	2415509
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	5.80e-07	2	27	2	2714789
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	5.80e-07	2	27	2	3197840
Pubmed	Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.	KMT2D NOTCH1	1.74e-06	3	27	2	27566587
Pubmed	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.	PGA4 PGA5	1.74e-06	3	27	2	2515193
Pubmed	Multiple roles of epithelial heparan sulfate in stomach morphogenesis.	PGA4 PGA5 PGA3	2.69e-06	35	27	3	29700203
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	PGA4 PGA5 PGA3	3.19e-06	37	27	3	21362171
Pubmed	Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.	PGA4 PGA5 PGA3	4.36e-06	41	27	3	23676500
Pubmed	Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.	OSBPL2 OSBPL1A	8.69e-06	6	27	2	10588946
Pubmed	The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.	OSBPL2 OSBPL1A	1.62e-05	8	27	2	17428193
Pubmed	The OSBP-related protein family in humans.	OSBPL2 OSBPL1A	3.18e-05	11	27	2	11483621
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	SLC12A3 NOTCH1	3.81e-05	12	27	2	27633993
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL2 OSBPL1A	3.81e-05	12	27	2	11735225
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL2 OSBPL1A	3.81e-05	12	27	2	12215260
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVFC1-1 ERVFC1	3.81e-05	12	27	2	14557543
Pubmed	Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.	SLC12A3 NOTCH1	8.81e-05	18	27	2	29113990
Pubmed	Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.	SLC12A3 NOTCH1	9.84e-05	19	27	2	34667084
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	KMT2D NOTCH1	4.01e-04	38	27	2	27930960
Pubmed	HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.	SLC12A3 NOTCH1	4.45e-04	40	27	2	23362348
Pubmed	Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.	SLC12A3 NOTCH1	5.88e-04	46	27	2	23555292
Cytoband	11q12.2	ZP1 PGA4 PGA3	1.63e-06	39	27	3	11q12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	MTA2 ZP1 PGA4 PGA5 PGA3	1.64e-06	345	27	5	chr11q12
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL2 OSBPL1A	5.46e-05	12	17	2	670
GeneFamily	PHD finger proteins	KMT2D NFX1	3.17e-03	90	17	2	88
Coexpression	NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON	TMEM134 PGA4 PGA5 PGA3	1.46e-05	158	25	4	M1493
ToppCell	wk_08-11-Hematologic-Myeloid-Neutrophil\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PGA4 CD244 PGA5 PGA3	3.27e-06	185	25	4	655fb705d7a029844ecb4f6a53e948e37ee81006
Disease	level of Phosphatidylcholine (18:0_20:4) in blood serum	PGA5 NXPH2	2.44e-04	31	22	2	OBA_2045094
Disease	Squamous cell carcinoma of esophagus	KMT2D NOTCH1	2.27e-03	95	22	2	C0279626
Disease	Bladder Neoplasm	KMT2D NOTCH1	4.85e-03	140	22	2	C0005695
Disease	Malignant neoplasm of urinary bladder	KMT2D NOTCH1	4.92e-03	141	22	2	C0005684
Disease	epilepsy (implicated_via_orthology)	SLC12A3 SLC13A2	6.52e-03	163	22	2	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QESYCSNWRCPTRVQ	C14orf28	151	Q4W4Y0
QSWSTFHCNCTNTGY	CNTNAP4	566	Q9C0A0
CYQEQTQSHVSWLCS	NXPH2	211	O95156
TCESCHTTQSAQWYA	MTA2	366	O94776
WVPSVYCSSLACTNH	PGA5	101	P0DJD9
CWEVYVCSQHSPANR	MDN1	2391	Q9NU22
QTHTQYRCECPSGWT	NOTCH1	1076	P46531
SPSQRCSRNWHYCSG	MAGEB5	246	Q9BZ81
FCYSTPNASWCNQTR	ERVFC1-1	331	P60608
RVTAPVWSCQSCYHV	NFX1	366	Q12986
EAYTWTNPTCCVHNI	OSBPL1A	701	Q9BXW6
WVPSVYCSSLACTNH	PGA3	101	P0DJD8
DVTQNPWHCDCSLTY	GP9	81	P14770
VHQVACYSCTSGQWS	KLHL22	511	Q53GT1
CQQTCWEPTSCQTSY	KRTAP13-1	56	Q8IUC0
PFCYTTPNSSWCNQT	ERVFC1	301	P60507
HSFPSWAQSNTTAQC	SLC13A2	566	Q13183
TYTCNVSNPVSWESH	CD244	196	Q9BZW8
WVPSVYCSSLACTNH	PGA4	101	P0DJD7
HNEAYTWTNPTCCVH	OSBPL2	226	Q9H1P3
CATTSCYQTQLSDWH	CNFN	11	Q9BYD5
NCSICYHWVTSRPQE	ZP1	76	P60852
WHNTVRCCNQYQESP	SPEM2	6	Q0P670
CSYGWNFTECTQQHS	SLC12A3	421	P55017
YRCSWCGKSFSHNTN	ZNF75D	421	P51815
TQRSYNTCCSWTQHP	TMEM134	101	Q9H6X4
LNTRTQHWTCSVCTY	ZRANB1	146	Q9UGI0
WQNSYTHCGPCASLV	KMT2D	1491	O14686