Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3CG PIP5K1A PIPSL PIP5K1C	3.34e-06	26	80	4	GO:0052742
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A PIPSL PIP5K1C	5.11e-06	9	80	3	GO:0016308
GeneOntologyMolecularFunction	lipid kinase activity	PIK3CG PIP5K1A PIPSL PIP5K1C	2.16e-05	41	80	4	GO:0001727
GeneOntologyMolecularFunction	cholesterol-protein transferase activity	SHH IHH	4.74e-05	3	80	2	GO:0140853
GeneOntologyMolecularFunction	very-low-density lipoprotein particle binding	IHH PCSK9	1.57e-04	5	80	2	GO:0034189
GeneOntologyMolecularFunction	patched binding	SHH IHH	4.37e-04	8	80	2	GO:0005113
GeneOntologyBiologicalProcess	phosphatidylinositol phosphate biosynthetic process	SYNJ2 PIK3CG PIP5K1A PIPSL PIP5K1C	4.75e-06	66	77	5	GO:0046854
GeneOntologyBiologicalProcess	intein-mediated protein splicing	SHH IHH	4.12e-05	3	77	2	GO:0016539
GeneOntologyBiologicalProcess	protein splicing	SHH IHH	4.12e-05	3	77	2	GO:0030908
GeneOntologyBiologicalProcess	phosphatidylinositol metabolic process	GPLD1 SYNJ2 PIK3CG PIP5K1A PIPSL PIP5K1C	4.19e-05	170	77	6	GO:0046488
Domain	INTEIN_N_TER	SHH IHH	1.68e-05	2	77	2	PS50817
Domain	Intein_N	SHH IHH	1.68e-05	2	77	2	IPR006141
Domain	Hedgehog_sig/DD-Pept_Zn-bd_dom	SHH IHH	5.02e-05	3	77	2	IPR009045
Domain	Hedgehog_signalling_dom	SHH IHH	5.02e-05	3	77	2	IPR000320
Domain	HintN	SHH IHH	5.02e-05	3	77	2	SM00306
Domain	HintC	SHH IHH	5.02e-05	3	77	2	SM00305
Domain	Hedgehog	SHH IHH	5.02e-05	3	77	2	IPR001657
Domain	Hint_dom	SHH IHH	5.02e-05	3	77	2	IPR001767
Domain	-	SHH IHH	5.02e-05	3	77	2	3.30.1380.10
Domain	Hint_dom_N	SHH IHH	5.02e-05	3	77	2	IPR003587
Domain	Hint_dom_C	SHH IHH	5.02e-05	3	77	2	IPR003586
Domain	HH_signal	SHH IHH	5.02e-05	3	77	2	PF01085
Domain	Hint	SHH IHH	5.02e-05	3	77	2	PF01079
Domain	WD40	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	9.57e-05	259	77	7	PF00400
Domain	WWE	DTX4 DTX2	1.00e-04	4	77	2	SM00678
Domain	WWE-dom_subgr	DTX4 DTX2	1.00e-04	4	77	2	IPR018123
Domain	-	SHH IHH	1.00e-04	4	77	2	2.170.16.10
Domain	Hedgehog/Intein_dom	SHH IHH	1.00e-04	4	77	2	IPR028992
Domain	WD40	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	1.18e-04	268	77	7	SM00320
Domain	WD40_repeat	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	1.30e-04	272	77	7	IPR001680
Domain	WD_REPEATS_1	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	1.48e-04	278	77	7	PS00678
Domain	WD_REPEATS_2	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	1.52e-04	279	77	7	PS50082
Domain	WD_REPEATS_REGION	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	1.52e-04	279	77	7	PS50294
Domain	WD40_repeat_dom	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	2.23e-04	297	77	7	IPR017986
Domain	PInositol-4-P-5-kinase	PIP5K1A PIP5K1C	3.48e-04	7	77	2	IPR023610
Domain	-	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	4.44e-04	333	77	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	4.60e-04	335	77	7	IPR015943
Domain	PIPKc	PIP5K1A PIP5K1C	4.62e-04	8	77	2	SM00330
Domain	-	PIP5K1A PIP5K1C	4.62e-04	8	77	2	3.30.800.10
Domain	PIP5K	PIP5K1A PIP5K1C	4.62e-04	8	77	2	PF01504
Domain	PIPK	PIP5K1A PIP5K1C	4.62e-04	8	77	2	PS51455
Domain	PInositol-4-P-5-kinase_N	PIP5K1A PIP5K1C	4.62e-04	8	77	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1A PIP5K1C	4.62e-04	8	77	2	IPR027483
Domain	-	PIP5K1A PIP5K1C	4.62e-04	8	77	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1A PIP5K1C	4.62e-04	8	77	2	IPR002498
Domain	LisH	TBL1Y TBL1XR1	5.93e-04	9	77	2	PF08513
Domain	Filamin	TRIM45 MYCBP2	9.01e-04	11	77	2	PF00630
Domain	FILAMIN_REPEAT	TRIM45 MYCBP2	9.01e-04	11	77	2	PS50194
Domain	NBPF_dom	NBPF11 NBPF14	9.01e-04	11	77	2	IPR010630
Domain	NBPF	NBPF11 NBPF14	9.01e-04	11	77	2	PS51316
Domain	Filamin/ABP280_rpt	TRIM45 MYCBP2	9.01e-04	11	77	2	IPR001298
Domain	Filamin/ABP280_repeat-like	TRIM45 MYCBP2	9.01e-04	11	77	2	IPR017868
Domain	DUF1220	NBPF11 NBPF14	9.01e-04	11	77	2	PF06758
Domain	WWE	DTX4 DTX2	1.08e-03	12	77	2	PS50918
Domain	WWE	DTX4 DTX2	1.08e-03	12	77	2	PF02825
Domain	WWE-dom	DTX4 DTX2	1.08e-03	12	77	2	IPR004170
Domain	-	MAN2A1 FUCA2	1.48e-03	14	77	2	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A1 FUCA2	1.70e-03	15	77	2	IPR013780
Domain	P4Hc	OGFOD1 OGFOD3	1.94e-03	16	77	2	SM00702
Domain	Pro_4_hyd_alph	OGFOD1 OGFOD3	1.94e-03	16	77	2	IPR006620
Domain	FE2OG_OXY	OGFOD1 OGFOD3	3.35e-03	21	77	2	PS51471
Domain	Oxoglu/Fe-dep_dioxygenase	OGFOD1 OGFOD3	4.01e-03	23	77	2	IPR005123
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	SYNJ2 PIK3CG PIP5K1A PIP5K1C ITPR2	2.20e-05	76	63	5	M9052
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	SYNJ2 PIK3CG PIP5K1A PIP5K1C	7.15e-05	50	63	4	MM14641
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	SYNJ2 PIK3CG PIP5K1A PIP5K1C	9.00e-05	53	63	4	M662
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	SYNJ2 PIK3CG PIP5K1A PIP5K1C	9.69e-05	54	63	4	M3896
Pathway	REACTOME_FORMATION_OF_LATERAL_PLATE_MESODERM	SHH IHH	1.95e-04	5	63	2	M46432
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_HH_LIGAND_SECRETION	SHH IHH	2.91e-04	6	63	2	M47892
Pathway	REACTOME_SIGNALING_BY_NOTCH1	DTX4 DTX2 TBL1XR1 CNTN1	3.30e-04	74	63	4	M616
Pathway	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	DTX4 DTX2 CNTN1	3.50e-04	31	63	3	M592
Pathway	REACTOME_PI_METABOLISM	SYNJ2 PIK3CG PIP5K1A PIP5K1C	3.84e-04	77	63	4	MM14590
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH IHH	4.07e-04	7	63	2	MM15187
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH IHH	4.07e-04	7	63	2	MM15224
Pathway	REACTOME_PI_METABOLISM	SYNJ2 PIK3CG PIP5K1A PIP5K1C	5.35e-04	84	63	4	M676
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH IHH	5.41e-04	8	63	2	M27444
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH IHH	5.41e-04	8	63	2	M27496
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	SHH IHH	6.93e-04	9	63	2	M47893
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF8 NBPF10 NBPF11 NBPF14	1.75e-07	21	83	4	16079250
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PIK3CG PIP5K1A PIP5K1C	2.61e-07	6	83	3	28581524
Pubmed	DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.	DTX4 WRN DTX3L DTX2	5.91e-07	28	83	4	32937373
Pubmed	Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium.	PIK3CG SHH IHH	3.68e-06	13	83	3	22275805
Pubmed	Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.	CD8B CD8B2	5.63e-06	2	83	2	5558567
Pubmed	Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.	SHH IHH	5.63e-06	2	83	2	28574612
Pubmed	Cloning and modeling of CD8 beta in the amphibian ambystoma Mexicanum. Evolutionary conserved structures for interactions with major histocompatibility complex (MHC) class I molecules.	CD8B CD8B2	5.63e-06	2	83	2	12034498
Pubmed	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.	SHH IHH	5.63e-06	2	83	2	20854074
Pubmed	Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.	SHH IHH	5.63e-06	2	83	2	23468532
Pubmed	Cholesterol modification of hedgehog signaling proteins in animal development.	SHH IHH	5.63e-06	2	83	2	8824192
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	12682053
Pubmed	Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.	SHH IHH	5.63e-06	2	83	2	15238161
Pubmed	Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.	CD8B CD8B2	5.63e-06	2	83	2	3035575
Pubmed	Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).	CD8B CD8B2	5.63e-06	2	83	2	3498943
Pubmed	An immunological role for the CD8 beta-chain.	CD8B CD8B2	5.63e-06	2	83	2	1534146
Pubmed	Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.	CD8B CD8B2	5.63e-06	2	83	2	8108731
Pubmed	Duality of the murine CD8 compartment.	CD8B CD8B2	5.63e-06	2	83	2	24594598
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	32376619
Pubmed	Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.	CD8B CD8B2	5.63e-06	2	83	2	7889415
Pubmed	Murine Ly-3 restriction fragment length polymorphism and transcript size differences.	CD8B CD8B2	5.63e-06	2	83	2	2576243
Pubmed	AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas.	CD8B CD8B2	5.63e-06	2	83	2	3025647
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	19153220
Pubmed	New insight into hedgehog signaling in hematological malignancies.	SHH IHH	5.63e-06	2	83	2	24991722
Pubmed	Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.	CD8B CD8B2	5.63e-06	2	83	2	2452747
Pubmed	Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes.	CD8B CD8B2	5.63e-06	2	83	2	9233619
Pubmed	The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.	SHH IHH	5.63e-06	2	83	2	26201092
Pubmed	Differential requirements for shh in mammary tissue and hair follicle morphogenesis.	SHH IHH	5.63e-06	2	83	2	12217324
Pubmed	Stalk region of beta-chain enhances the coreceptor function of CD8.	CD8B CD8B2	5.63e-06	2	83	2	12847256
Pubmed	The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.	CD8B CD8B2	5.63e-06	2	83	2	9647223
Pubmed	Hedgehog signaling regulates expansion of pancreatic epithelial cells.	SHH IHH	5.63e-06	2	83	2	15766752
Pubmed	Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.	SHH IHH	5.63e-06	2	83	2	29088246
Pubmed	Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.	SHH IHH	5.63e-06	2	83	2	19856079
Pubmed	Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.	SHH IHH	5.63e-06	2	83	2	24344235
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	23300084
Pubmed	The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.	CD8B CD8B2	5.63e-06	2	83	2	408079
Pubmed	IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.	SHH IHH	5.63e-06	2	83	2	36853961
Pubmed	Transcriptional diversity at the duplicated human CD8 beta loci.	CD8B CD8B2	5.63e-06	2	83	2	8436166
Pubmed	Characterization of the mouse CD8 beta chain-encoding gene promoter region.	CD8B CD8B2	5.63e-06	2	83	2	8781121
Pubmed	Structure and expression of the Lyt-3a gene of C.AKR mice.	CD8B CD8B2	5.63e-06	2	83	2	3169881
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1A PIP5K1C	5.63e-06	2	83	2	19889969
Pubmed	Esr, a second locus in the house mouse controlling esterase-5.	CD8B CD8B2	5.63e-06	2	83	2	7103930
Pubmed	Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.	SHH IHH	5.63e-06	2	83	2	14520411
Pubmed	Increased production of sonic hedgehog by ballooned hepatocytes.	SHH IHH	5.63e-06	2	83	2	21547909
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CFAP20DC DPYSL2 ABR MYCBP2 SYNJ2 KIZ PIP5K1A LTBR MCCC2 TARS2 ZHX2 TBL1XR1 SESN1 ARAP1	1.09e-05	1489	83	14	28611215
Pubmed	Hedgehog signaling maintains resident hepatic progenitors throughout life.	SHH IHH	1.69e-05	3	83	2	16322088
Pubmed	Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.	SHH IHH	1.69e-05	3	83	2	21537345
Pubmed	[Hedgehog signaling pathway and its impact on development of cancer therapy].	SHH IHH	1.69e-05	3	83	2	18788453
Pubmed	Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.	SHH IHH	1.69e-05	3	83	2	19109233
Pubmed	Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).	SHH IHH	1.69e-05	3	83	2	26691363
Pubmed	Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.	CD8B CD8B2	1.69e-05	3	83	2	3258885
Pubmed	The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease.	SHH IHH	1.69e-05	3	83	2	18063705
Pubmed	Ly-36: a new mouse lymphocyte alloantigen defined by a Mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to Ly-2/3 region on chromosome 6.	CD8B CD8B2	1.69e-05	3	83	2	3378837
Pubmed	CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.	CD8B CD8B2	1.69e-05	3	83	2	22081144
Pubmed	Recent duplication of the two human CD8 beta-chain genes.	CD8B CD8B2	1.69e-05	3	83	2	1541829
Pubmed	Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.	CD8B CD8B2	1.69e-05	3	83	2	100557
Pubmed	Zinc is essential for binding of p56(lck) to CD4 and CD8alpha.	CD8B CD8B2	1.69e-05	3	83	2	9830036
Pubmed	Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.	CD8B CD8B2	1.69e-05	3	83	2	16356863
Pubmed	Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.	CD8B CD8B2	1.69e-05	3	83	2	4547628
Pubmed	The hedgehog signaling pathway in the mouse ovary.	SHH IHH	1.69e-05	3	83	2	17392501
Pubmed	Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.	CD8B CD8B2	1.69e-05	3	83	2	2998983
Pubmed	The world according to hedgehog.	SHH IHH	1.69e-05	3	83	2	9009843
Pubmed	Molecular biology and function of CD4 and CD8.	CD8B CD8B2	1.69e-05	3	83	2	2493728
Pubmed	Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene.	CD8B CD8B2	1.69e-05	3	83	2	9218488
Pubmed	A new mouse lymphocyte alloantigen (Ly-35) controlled by the Ly-2/3 region on chromosome 6.	CD8B CD8B2	1.69e-05	3	83	2	3346044
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1A PIP5K1C	1.69e-05	3	83	2	14681219
Pubmed	Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.	CD8B CD8B2	1.69e-05	3	83	2	23311920
Pubmed	CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.	PIP5K1A PIP5K1C	1.69e-05	3	83	2	33079727
Pubmed	Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.	CD8B CD8B2	1.69e-05	3	83	2	12810689
Pubmed	Hedgehog signal transduction: from flies to vertebrates.	SHH IHH	1.69e-05	3	83	2	10579908
Pubmed	A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.	CD8B CD8B2	1.69e-05	3	83	2	9126989
Pubmed	CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.	CD8B CD8B2	1.69e-05	3	83	2	11754824
Pubmed	The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney.	CD8B CD8B2	1.69e-05	3	83	2	7236294
Pubmed	Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells.	CD8B CD8B2	1.69e-05	3	83	2	31980555
Pubmed	An essential role for the stalk region of CD8 beta in the coreceptor function of CD8.	CD8B CD8B2	1.69e-05	3	83	2	19109142
Pubmed	Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse.	CD8B CD8B2	1.69e-05	3	83	2	9878266
Pubmed	Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.	CD8B CD8B2	1.69e-05	3	83	2	19625641
Pubmed	The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.	CD8B CD8B2	1.69e-05	3	83	2	18929574
Pubmed	Recombination between kappa chain genetic markers in the mouse.	CD8B CD8B2	1.69e-05	3	83	2	6437974
Pubmed	Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.	CD8B CD8B2	1.69e-05	3	83	2	11131152
Pubmed	The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.	SHH IHH	1.69e-05	3	83	2	11476578
Pubmed	Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.	CD8B CD8B2	1.69e-05	3	83	2	10795739
Pubmed	Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.	CD8B CD8B2	1.69e-05	3	83	2	8064243
Pubmed	Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.	CD8B CD8B2	1.69e-05	3	83	2	24807710
Pubmed	CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?	CD8B CD8B2	1.69e-05	3	83	2	19088062
Pubmed	CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR.	CD8B CD8B2	1.69e-05	3	83	2	17506031
Pubmed	Bop: a new T-cell-restricted gene located upstream of and opposite to mouse CD8b.	CD8B CD8B2	1.69e-05	3	83	2	7590968
Pubmed	Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.	CD8B CD8B2	1.69e-05	3	83	2	11719190
Pubmed	Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.	CD8B CD8B2	1.69e-05	3	83	2	2875941
Pubmed	Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.	CD8B CD8B2	1.69e-05	3	83	2	14568922
Pubmed	The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle.	CD8B CD8B2	1.69e-05	3	83	2	9013956
Pubmed	The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.	CD8B CD8B2	1.69e-05	3	83	2	9973530
Pubmed	Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation.	CD8B CD8B2	1.69e-05	3	83	2	8423051
Pubmed	T cells develop normally in the absence of both Deltex1 and Deltex2.	DTX4 DTX2	1.69e-05	3	83	2	16923970
Pubmed	Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments.	CD8B CD8B2	1.69e-05	3	83	2	2784466
Pubmed	Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.	SHH IHH	1.69e-05	3	83	2	11784093
Pubmed	PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.	PIP5K1A PIP5K1C	1.69e-05	3	83	2	23342003
Pubmed	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.	PIP5K1A PIP5K1C	1.69e-05	3	83	2	22942276
Pubmed	Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.	SHH IHH	1.69e-05	3	83	2	12587916
Pubmed	Isolation of P1 bacteriophage clones containing large contiguous segments of the human and mouse loci for the T-cell coreceptor molecule CD8.	CD8B CD8B2	1.69e-05	3	83	2	7710778
Cytoband	1q21.1	NBPF8 NBPF10 NBPF11 NBPF14	5.11e-06	62	83	4	1q21.1
Cytoband	7q22.3	NAMPT PIK3CG	6.01e-04	20	83	2	7q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p11	NBPF8 NBPF26	6.63e-04	21	83	2	chr1p11
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	NBPF10 PIP5K1A NBPF11 TARS2 NBPF14	8.52e-04	404	83	5	chr1q21
GeneFamily	Neuroblastoma breakpoint family	NBPF8 NBPF10 NBPF26 NBPF11 NBPF14	5.23e-09	23	52	5	662
GeneFamily	WD repeat domain containing	DMXL2 TBL1Y ARPC1A WDR55 EML1 TBL1XR1 SEC13	9.50e-06	262	52	7	362
Coexpression	GSE18893_TCONV_VS_TREG_2H_CULTURE_DN	GPLD1 NAMPT MAN2A1 ABR WFS1 ARPC1A DTX3L	3.45e-06	200	83	7	M7293
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_200	TRANK1 MYBL1	1.44e-05	2	81	2	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_200
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|390C / Donor, Lineage, Cell class and subclass (all cells)	EPHB6 DMXL2 PPP1R3F PDP2 PIP5K1C NCAPH	1.21e-06	183	83	6	228092290dbb08785c4eda224e3ad03e99e10fab
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NAMPT NBPF26 LTBR ADA2 ARAP1	1.65e-06	193	83	6	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	RSV-Healthy-2\|Healthy / Virus stimulation, Condition and Cluster	TRIM45 CATSPER1 CD8B WRN NCAPH	1.91e-05	175	83	5	c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCell	RSV-Healthy-2\|RSV / Virus stimulation, Condition and Cluster	TRIM45 CATSPER1 CD8B WRN NCAPH	1.91e-05	175	83	5	0e97189585b7afaf3bd622c3ef10c86412393829
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD8B COQ6 WRN OGFOD3 PEAK1	2.31e-05	182	83	5	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	COQ6 WRN OGFOD3 TARS2 PIP5K1C	2.37e-05	183	83	5	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	TRANK1 MARF1 NBPF10 DTX3L ADA2	2.37e-05	183	83	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	droplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GADD45B PECR FADS3 ENPP1 OGFOD3	2.49e-05	185	83	5	e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DMXL2 MYCBP2 CDIN1 PDP2 ITPR2	2.56e-05	186	83	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	control-Myeloid-CD14_Monocytes_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DMXL2 DPYSL2 PKDREJ ADA2 HSP90AB1	2.76e-05	189	83	5	7f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAN2A1 SYNJ2 KIZ WRN ITPR2	2.98e-05	192	83	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAN2A1 SYNJ2 KIZ WRN ITPR2	3.05e-05	193	83	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NBPF26 LTBR ADA2 ARAP1	3.13e-05	194	83	5	a94f9f7179a5733e3c378ff8b337e288785433a1
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NBPF26 LTBR ADA2 ARAP1	3.29e-05	196	83	5	89ff93cbfbe39fbdf2498e8fdc5d61a0ecb26fc9
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NBPF26 LTBR ADA2 ARAP1	3.29e-05	196	83	5	09574bfeb1d3da53b5471cfb0602946d328b3b5c
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	GADD45B TRANK1 CD8B DTX3L ADA2	3.29e-05	196	83	5	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 DPYSL2 NAMPT NBPF14 ADA2	3.29e-05	196	83	5	5bcb57c57d5da0440220a1133a96aa89407bd871
ToppCell	B_cells-Plasmablasts\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	WFS1 NANS FUCA2 ADA2 SEC13	3.45e-05	198	83	5	c6cab47885be74a64351f843a741dea6d911bde4
ToppCell	control-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 DPYSL2 NAMPT LTBR ARAP1	3.45e-05	198	83	5	35499a5231818e3432cf69b5c4a58c02f7771db8
ToppCell	(22)_CD8+_T_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	CD6 CD8B CD8B2 MYBL1 HSP90AB1	3.53e-05	199	83	5	e1261507f0adade3ba534d5b465c9c559fc3aed0
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	TRANK1 NBPF10 DTX3L PEAK1 MYBL1	3.62e-05	200	83	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Severe-B_intermediate-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TRANK1 MARF1 NBPF10 NBPF11	9.08e-05	126	83	4	42a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCell	NS-moderate-d_07-13-Epithelial-unknown_epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NBPF8 GADD45B ENPP1 MUC16	1.02e-04	130	83	4	1491e8975520e99c527a5b5bee64875d124f7bf4
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 CD6 CD8B PEAK1	1.29e-04	138	83	4	19ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 CD6 CD8B PEAK1	1.29e-04	138	83	4	321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD8-positive,_alpha-beta_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD6 CD8B CD8B2 MYBL1	1.40e-04	141	83	4	bb77b8d12e33dc82859abd79e56a574781f815dc
ToppCell	Dividing_Macrophages-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TRIM45 CFAP20DC NCAPH MYBL1	1.87e-04	152	83	4	e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCell	Healthy/Control-CD8+_T_naive\|World / Disease group and Cell class	TCP10L CD8B CD8B2 EML1	2.17e-04	158	83	4	70680b29428b6bf882b1fae36f924b775961176b
ToppCell	Healthy/Control-CD8+_T_naive\|Healthy/Control / Disease group and Cell class	TCP10L CD8B CD8B2 EML1	2.27e-04	160	83	4	e1386c21fcbbf57fa32d8bdfba3cb1887477ff73
ToppCell	metastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	GADD45B CD8B KIZ MUC16	2.33e-04	161	83	4	e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD6 CD8B ENPP1 TARS2	2.39e-04	162	83	4	58fe827198c172eeaa26273b0fad7991a718b0bf
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD6 CD8B MYBL1 HSP90AB1	2.39e-04	162	83	4	3b89c3758835b7b9f9d4fb0bc8ed06da382fe48b
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRANK1 DTX3L CNTN1 ITPR2	2.44e-04	163	83	4	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	368C-Myeloid-Dendritic-cDC1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CLCN2 CD8B ENPP1 PCSK9	2.44e-04	163	83	4	299ac2463b7f58eee419d822a2a2d64b973d87e9
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD6 CD8B WRN MYBL1	2.50e-04	164	83	4	30c3c25b05a403a509b2e755c2f0878fecb10a02
ToppCell	10x5'-Liver-Hematopoietic_progenitors\|Liver / Manually curated celltypes from each tissue	CFAP20DC CATSPER1 LTBR NCAPH	2.62e-04	166	83	4	ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell	10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Liver / Manually curated celltypes from each tissue	CFAP20DC CATSPER1 LTBR NCAPH	2.62e-04	166	83	4	a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TRANK1 MARF1 NBPF10 NBPF11	2.68e-04	167	83	4	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.68e-04	167	83	4	94642b3dae035fedb6e8b9745f440096a4539f3c
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.68e-04	167	83	4	42b299273a6c72a625b204d55f4f3c4eebd6d185
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.68e-04	167	83	4	ecf5bc634e1e01efd783617eb81d1704e903ea21
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD6 CD8B PDP2 MYBL1	2.74e-04	168	83	4	50991eb794742592a0c96cd9a72460ab339e74ff
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.80e-04	169	83	4	e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.80e-04	169	83	4	d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNJ2 ENPP1 IGDCC4 MYBL1	2.80e-04	169	83	4	58f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 PIK3CG CNTN1 ITPR2	2.87e-04	170	83	4	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3CG CDIN1 NCAPH MYBL1	2.93e-04	171	83	4	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like\|blood / Manually curated celltypes from each tissue	GADD45B SESN1 MYBL1 HSP90AB1	3.13e-04	174	83	4	51be6f29308c01593978cbee92114151a5916c9c
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MUC16 ZNF112 CNTN1 PCSK9	3.13e-04	174	83	4	4da79da7a09ee1e345102c5331675ebcdbe56171
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	ADAMTSL1 MARF1 NBPF10 ADA2	3.20e-04	175	83	4	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like-MAIT\|blood / Manually curated celltypes from each tissue	GADD45B SESN1 MYBL1 HSP90AB1	3.20e-04	175	83	4	b4e4b66e89f79999768a6192c8404cb2465f920b
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD6 CD8B PCSK9 ITPR2	3.27e-04	176	83	4	acd05ca8952710feedbfe377b1330f3c2406d044
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRANK1 MARF1 DTX3L MYBL1	3.34e-04	177	83	4	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 NAMPT ZHX2 ITPR2	3.34e-04	177	83	4	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRANK1 MARF1 DTX3L MYBL1	3.34e-04	177	83	4	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	TRANK1 MARF1 DTX3L MYBL1	3.34e-04	177	83	4	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TRANK1 MARF1 DTX3L MYBL1	3.34e-04	177	83	4	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TRANK1 MARF1 DTX3L MYBL1	3.34e-04	177	83	4	d5aeda113afaa2425874394610344570c9078478
ToppCell	3'-Adult-SmallIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD6 MYCBP2 ADA2 MYBL1	3.41e-04	178	83	4	da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|343B / Donor, Lineage, Cell class and subclass (all cells)	PECR CD6 WRN NCAPH	3.41e-04	178	83	4	5289ac61637224ae70ffbc2d164d73116f10af40
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|343B / Donor, Lineage, Cell class and subclass (all cells)	CD8B COQ6 WRN PEAK1	3.41e-04	178	83	4	ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD6 MYCBP2 ADA2 MYBL1	3.41e-04	178	83	4	580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCell	Control-T/NK-NK\|Control / Disease group,lineage and cell class （2021.01.30）	SYNJ2 ENPP1 IGDCC4 MYBL1	3.41e-04	178	83	4	079fd19bdeed86bf985c4083af432432d66ad546
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD6 CD8B CD8B2 MYBL1	3.56e-04	180	83	4	557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EML1 CNTN1 PCSK9 GGT7	3.56e-04	180	83	4	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	Adult-Immune-natural_killer_cell-D175\|Adult / Lineage, Cell type, age group and donor	CD6 CD8B NCAPH MYBL1	3.56e-04	180	83	4	fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EML1 CNTN1 PCSK9 GGT7	3.56e-04	180	83	4	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD6 CD8B ENPP1 GGT7	3.63e-04	181	83	4	41969fe4d94ee77b12ecde32170aaf0b13e49644
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD6 CD8B ENPP1 GGT7	3.63e-04	181	83	4	3f50e61dc2a52d71a5801584617607e6246adcf2
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD8_Naive\|Leuk-UTI / Disease, Lineage and Cell Type	CD6 CD8B KIZ HSP90AB1	3.71e-04	182	83	4	3500a826d86beb98980e2b24e074b02e8e2f957e
ToppCell	CD8+_Memory_T_cell-RSV-2\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	NAMPT CATSPER1 NANS NCAPH	3.71e-04	182	83	4	f5f17a80552f0ad05ed1a2529a04ee55deb1e130
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	GPLD1 PECR MYCBP2 TBL1Y	3.79e-04	183	83	4	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 CLCN2 ENPP1 PCSK9	3.79e-04	183	83	4	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	COQ6 WRN TARS2 PIP5K1C	3.79e-04	183	83	4	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TBL1Y NBPF10 NBPF14 ITPR2	3.87e-04	184	83	4	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NBPF26 LTBR ARAP1	3.87e-04	184	83	4	bc0dfe29337f02594e7e0092c9e47dda94b45ad5
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	DMXL2 MYCBP2 CDIN1 PDP2	3.95e-04	185	83	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 ZNF112 CNTN1 MYBL1	4.03e-04	186	83	4	aa88d9573a237b2b8e6025fee31f69fbce824497
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB6 ZNF112 CNTN1 MYBL1	4.03e-04	186	83	4	ecc5acd111a6ee50d59544d1bdd7ed94e2812aae
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	COQ6 WRN OGFOD3 PEAK1	4.03e-04	186	83	4	bbb8edea8d8bdc1a469faec1563e40b1f62d7f3d
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB6 ZNF112 CNTN1 MYBL1	4.03e-04	186	83	4	26458ff8cad5577de4306cffa0ca69eb26940e0d
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB6 ZNF112 CNTN1 MYBL1	4.03e-04	186	83	4	a71397efc68d2916ddc373d92cfd07be58033e1c
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell\|TCGA-Uvea / Sample_Type by Project: Shred V9	WDR55 MCCC2 NCAPH ITPR2	4.03e-04	186	83	4	e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EPHB6 DMXL2 PPP1R3F NCAPH	4.03e-04	186	83	4	74eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	EPHB6 DPYSL2 NANS HSP90AB1	4.11e-04	187	83	4	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	DMXL2 PDP2 PIP5K1C NCAPH	4.11e-04	187	83	4	1eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCell	ASK454-Epithelial-Type_1\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FADS3 WFS1 PPP1R3F ZNF112	4.19e-04	188	83	4	13f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 ADAMTSL1 GJC1 EML1	4.19e-04	188	83	4	d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	PECR NAMPT MYCBP2 ITPR2	4.19e-04	188	83	4	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	NAMPT NBPF10 NBPF26 NBPF14	4.28e-04	189	83	4	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	Non-neuronal-Non-dividing-OPC-OPC\|World / Primary Cells by Cluster	KIZ PEAK1 CNTN1 ITPR2	4.28e-04	189	83	4	ddf5be73912570c32c50f4ac2902da9b590526f8
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GADD45B CD6 CD8B MYBL1	4.28e-04	189	83	4	f1129eb122bbc051457c5545f1a267beb988b0f2
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CytoT_GZMK+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GADD45B CD6 CD8B MYBL1	4.28e-04	189	83	4	0b012ee301419fa9ccc387c3ff66c2344b349a97
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	ANO2 ADAMTSL1 NAMPT ITPR2	4.28e-04	189	83	4	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	Non-neuronal-Non-dividing-OPC\|World / Primary Cells by Cluster	KIZ PEAK1 CNTN1 ITPR2	4.28e-04	189	83	4	13848a031ab896b4b24c8319e4745b9b17ff9cfd
ToppCell	Non-neuronal-Non-dividing-OPC-OPC-30\|World / Primary Cells by Cluster	KIZ PEAK1 CNTN1 ITPR2	4.28e-04	189	83	4	313d165fad541ec6e8dd524b88856e2c93eeb681
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF10 NBPF26 ZHX2 NBPF14	4.36e-04	190	83	4	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 NAMPT LTBR ARAP1	4.36e-04	190	83	4	18c020ca9a23399214133ec255ab870e0060f2e1
ToppCell	facs-Marrow-KLS-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM45 DTX4 LTBR FUCA2	4.36e-04	190	83	4	c03c735a0ed850bf460a1847f5e2dd61753e577d
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF10 NBPF26 ZHX2 NBPF14	4.36e-04	190	83	4	1c3d601422efa60fad8565f9ccd9032b847e4a91
Drug	Amitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; HL60; HT_HG-U133A	DMXL2 SYNJ2 DTX4 ZNF91 PIP5K1C ARAP1 ITPR2	4.11e-06	188	79	7	1865_DN
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1	2.17e-05	3	80	2	DOID:0050155 (implicated_via_orthology)
Disease	autism spectrum disorder (is_marker_for)	SHH IHH	1.51e-04	7	80	2	DOID:0060041 (is_marker_for)
Disease	primary bacterial infectious disease (implicated_via_orthology)	SHH IHH	2.58e-04	9	80	2	DOID:0050338 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	PIP5K1A PIPSL PIP5K1C HSP90AB1 HSP90AB3P	8.22e-04	268	80	5	DOID:162 (implicated_via_orthology)
Disease	diabetes mellitus	MYCBP2 WFS1 ARAP1	8.47e-04	68	80	3	EFO_0000400
Disease	Carcinoma of bladder	PEAK1 TBL1XR1	1.08e-03	18	80	2	C0699885
Disease	age at onset, smoking initiation	MYCBP2 ITPR2	1.20e-03	19	80	2	EFO_0004847, EFO_0005670
Disease	TYPE 2 DIABETES MELLITUS	WFS1 ENPP1	2.62e-03	28	80	2	125853
Disease	Type 2 diabetes mellitus	WFS1 ENPP1	2.62e-03	28	80	2	cv:C0011860

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESKAHLTSAADIWSH	ABR	811	Q12979
VHTQDISTKHSEDWG	CATSPER1	381	Q8NEC5
WSTSHEHAAELVSMD	COQ6	271	Q9Y2Z9
KHLVHLDWVSKEDGS	DMXL2	1166	Q8TDJ6
AGETDSAHSKHPEQW	ANO2	716	Q9NQ90
GESDTVIWNEVHHKT	DTX4	566	Q9Y2E6
WVSHDSTVSVADASK	ARPC1A	221	Q92747
TWSKDGDTLLEHDHL	IGDCC4	71	Q8TDY8
TSSKALWEIEVVHHD	ITPR2	276	Q14571
HKEDAGAVCSEHQSW	CD6	251	P30203
KVCEALEHGHVEWSS	OGFOD1	306	Q8N543
VETTGWVTSSEHASH	MUC16	3951	Q8WXI7
DWEDHLAVKHFSVEG	HSP90AB1	311	P08238
TSGSENLHRVEKVHW	OGFOD3	281	Q6PK18
TVDVWTLHAELHEGL	KIAA0100	221	Q14667
HCRKSGVSDHWALDD	MCCC2	266	Q9HCC0
FQHHDAITGTAKDWV	MAN2A1	566	Q16706
IELAKSPESHGHWRE	DNAAF2	596	Q9NVR5
SLHVDISEWHKGIQE	DPYSL2	136	Q16555
GETDTVVWNEIHHKT	DTX2	571	Q86UW9
TSDWEDHLAVKHFSV	HSP90AB3P	251	Q58FF7
WEKDGQHLISSTHVT	ADAMTSL1	911	Q8N6G6
GHVLTGCSSHWEVED	PCSK9	556	Q8NBP7
GCSSHWEVEDLGTHK	PCSK9	561	Q8NBP7
ARGHHVEKVDVLSWV	GGT7	621	Q9UJ14
HHWFTEAKGESSEKP	PEAK1	971	Q9H792
AEHISSKGWHAVLET	PECR	116	Q9BY49
ESCVHGKHDSSWVEE	ENPP1	866	P22413
SQEKHSPWEGVSDHL	KIZ	336	Q2M2Z5
MEEHALTVHESLSSW	GOLGA3	1446	Q08378
EHSWKALVHDGDTVS	PIP5K1A	416	Q99755
WKALIHDGDTVSVHR	PIPSL	366	A2A3N6
LVVGHLAEADWHKTD	PDP2	426	Q9P2J9
LTSKHHEGFTLWGSE	FUCA2	131	Q9BTY2
HHEFLTLWDSAKGTI	CD8B2	66	A6NJW9
GVSDVITWNDIHHKT	DTX3L	696	Q8TDB6
EGHIIHWIESKASFG	CDIN1	206	Q9Y2V0
HWIESKASFGDECSH	CDIN1	211	Q9Y2V0
HHEFLALWDSAKGTI	CD8B	66	P10966
EEIHNHSTFVGKIWL	GJC1	11	P36383
HTDAWKSHGLVEVAS	GADD45B	126	O75293
SSSEISVHWEHVLEK	CNTN1	821	Q12860
SGEHHDEEWSVKTYQ	ADA2	256	Q9NZK5
WEGTTHLSVEELKRH	MARF1	1426	Q9Y4F3
GHTDELWGLAIHASK	EML1	541	O00423
KEIGHEKHRDWVSSQ	FADS3	346	Q9Y5Q0
EQHGTDDWTLIASHL	MYBL1	51	P10243
KLRVTEGWDEDGHHS	IHH	126	Q14623
GTWEKSHEHAGHDSS	SEC13	91	P55735
EGKAVFWHSSTHVLG	TARS2	126	Q9BW92
FTSNVIHKHGDSVWE	TRIM45	226	Q9H8W5
EHIEGLLKAEEHSWS	SESN1	181	Q9Y6P5
KLRVTEGWDEDGHHS	SHH	121	Q15465
DHEHKTLGHWVTISD	SYNJ2	1466	O15056
SLWADVHGKLRSHID	TCP10L	66	Q8TDR4
LIGSSSHVEWEDAVH	NBPF8	476	Q3BBV2
LIGSSSHVEWEDAVH	NBPF10	511	Q6P3W6
LIGSSSHVEWEDAVH	NBPF11	511	Q86T75
LIGSSSHVEWEDAVH	NBPF14	171	Q5TI25
LIGSSSHVEWEDAVH	NBPF26	171	B4DH59
NSEASSWKESESEHH	SSMEM1	156	Q8WWF3
HTWKALVHDGDTVSV	PIP5K1C	411	O60331
TKSDLGDIHSIRVWH	PKDREJ	1286	Q9NTG1
EVIAHGKHTTSSDVW	EPHB6	831	O15197
ERHITLDKTWKGSDH	NANS	236	Q9NR45
ADISDIIHSTEKGDW	MYCBP2	4086	O75592
EHSTITAWGKDHEKD	NAMPT	246	P43490
TAWGKDHEKDAFEHI	NAMPT	251	P43490
TWDPTLDHLAKHDGE	WRN	346	Q14191
VDKTTIIWDAHTGEA	TBL1XR1	286	Q9BZK7
TCWGFTVVHETEKHE	ARAP1	1356	Q96P48
SHLWLEASKESEHDQ	CFAP20DC	326	Q6ZVT6
HTAVGDHEEFRSWKE	NCAPH	381	Q15003
DTETTEVHALWGPHS	CLCN2	866	P51788
IHGKDHESVFTVSLW	PIK3CG	341	P48736
AFSHKVQLWHEEDSG	nan	156	Q6ZTK2
HEAVVSLHVSKVWDD	THOC2	861	Q8NI27
KGGKFHDVSESTHWT	GPLD1	76	P80108
GITSHMAADVSWHSL	GPLD1	121	P80108
EKAVHVRASHDGWAS	PPP1R3F	176	Q6ZSY5
VDKTTIIWDAHTGEA	TBL1Y	296	Q9BQ87
TPHQEDGKAWHLAET	LTBR	401	P36941
WSSTLTNHKEIHTED	ZNF91	221	Q05481
DSVSWLSHHNDKLEV	ZNF112	211	Q9UJU3
ELSWLTAASKHPEEH	ZHX2	291	Q9Y6X8
EGETKELWSSGHHLK	WDR55	71	Q9H6Y2
EQSVWIHSHVGSKEH	TRANK1	2816	O15050
KVEEDHGWDQESSLH	ZKSCAN8	26	Q15776
VKIEHDWRSTVHGAV	WFS1	861	O76024