Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	IGHMBP2 NAV1 DDX51 CHD6 CHD1L ABCC6 KIF7	1.57e-04	441	53	7	GO:0016887
Domain	ARHGEF5_35	ARHGEF35 ARHGEF5	8.51e-06	2	55	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF35 ARHGEF5	8.51e-06	2	55	2	IPR029212
Domain	DEXDc	IGHMBP2 DDX51 CHD6 CHD1L	2.98e-04	109	55	4	SM00487
Domain	Helicase_ATP-bd	IGHMBP2 DDX51 CHD6 CHD1L	3.08e-04	110	55	4	IPR014001
Domain	SH3_2	ARHGEF5 MAP3K9 RUSC2	2.08e-03	86	55	3	IPR011511
Domain	SH3_2	ARHGEF5 MAP3K9 RUSC2	2.08e-03	86	55	3	PF07653
Domain	DEATH	UNC5CL NFKB1	2.85e-03	27	55	2	SM00005
Domain	P-loop_NTPase	IGHMBP2 NAV1 NLRC5 DDX51 CHD6 CHD1L ABCC6 KIF7	3.20e-03	848	55	8	IPR027417
Domain	Helicase_C	DDX51 CHD6 CHD1L	3.86e-03	107	55	3	PF00271
Domain	HELICc	DDX51 CHD6 CHD1L	3.86e-03	107	55	3	SM00490
Domain	Helicase_C	DDX51 CHD6 CHD1L	3.97e-03	108	55	3	IPR001650
Domain	SNF2_N	CHD6 CHD1L	3.99e-03	32	55	2	IPR000330
Domain	SNF2_N	CHD6 CHD1L	3.99e-03	32	55	2	PF00176
Domain	HELICASE_CTER	DDX51 CHD6 CHD1L	4.07e-03	109	55	3	PS51194
Domain	HELICASE_ATP_BIND_1	DDX51 CHD6 CHD1L	4.07e-03	109	55	3	PS51192
Domain	Death	UNC5CL NFKB1	4.24e-03	33	55	2	PF00531
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PANK2 LIMD1 ARHGEF5 MAP3K9 NAV1 AKAP13 PUM1 CIC SPICE1 RUSC2	1.04e-06	861	56	10	36931259
Pubmed	NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway.	NFKB1 NLRC5	7.63e-06	3	56	2	34438368
Pubmed	HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis.	NFKB1 NLRC5	7.63e-06	3	56	2	30872089
Pubmed	Adipose tissue inflammation and VDR expression and methylation in colorectal cancer.	NFKB1 DNMT3A	7.63e-06	3	56	2	29719581
Pubmed	TIP150 interacts with and targets MCAK at the microtubule plus ends.	MAPRE1 MTUS2	7.63e-06	3	56	2	19543227
Pubmed	Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.	UNC5CL NFKB1	7.63e-06	3	56	2	14769797
Pubmed	NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4/NF-κB.	NFKB1 NLRC5	7.63e-06	3	56	2	28499247
Pubmed	AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.	NFKB1 AKAP13	7.63e-06	3	56	2	17878165
Pubmed	Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis.	MAPRE1 MTUS2	1.52e-05	4	56	2	23595990
Pubmed	Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells.	TRIM33 CHD1L	1.52e-05	4	56	2	33053171
Pubmed	E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.	TRIM33 NFKB1	1.52e-05	4	56	2	36096861
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KHNYN CIC RUSC2 PDZD2	2.46e-05	104	56	4	9205841
Pubmed	Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch.	NFKB1 NLRC5	2.54e-05	5	56	2	26620909
Pubmed	Modulation of SRF-dependent gene expression by association of SPT16 with MKL1.	MAP3K9 MRTFA	2.54e-05	5	56	2	18036521
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	TRIM33 THBS4 EMG1 SRP68 CHD6 PUM1 MRTFA KHSRP	2.67e-05	754	56	8	35906200
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SPTBN4 MAN1A2 CGREF1 DDX51 LMTK3 PUM1 CD99L2 KIF7 DNMT3A	3.43e-05	1021	56	9	26760575
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	NFKB1 ACBD5 NAV1 AKAP13 PUM1	3.66e-05	232	56	5	25515538
Pubmed	New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.	ZNF469 AKAP13	3.80e-05	6	56	2	20719862
Pubmed	Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.	TRIM33 CHD1L	3.80e-05	6	56	2	23926104
Pubmed	De novo gene disruptions in children on the autistic spectrum.	LMTK3 CIC	3.80e-05	6	56	2	22542183
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TRIM33 LIMD1 NFKB1 KHNYN SRP68 PUM1 MRTFA SPICE1 RUSC2	3.90e-05	1038	56	9	26673895
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KHNYN NAV1 CHD6 PUM1 RUSC2 PDZD2	4.90e-05	407	56	6	12693553
Pubmed	CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.	DRD3 CLIC6	5.32e-05	7	56	2	14499480
Pubmed	Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.	MAPRE1 NAV1	5.32e-05	7	56	2	25065758
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF469 ARHGEF5 AKAP13 LMTK3 CIC MRTFA	6.64e-05	430	56	6	35044719
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ELOA2 SRP68 DDX51 CHD6 ABCC6 CIC KIF7	7.20e-05	638	56	7	31182584
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NAV1 SRP68 CHD6 CHD1L KIF7 SPICE1 DNMT3A	7.70e-05	645	56	7	25281560
Pubmed	iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.	MAPRE1 NFKB1	9.10e-05	9	56	2	29743530
Pubmed	TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.	SPTBN4 NAV1	9.10e-05	9	56	2	26671463
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	MAPRE1 MTUS2	1.14e-04	10	56	2	23001180
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRIM33 MAN1A2 CGREF1 IGHMBP2 ACBD5 EMG1 SRP68 DDX51 CHD6 CIC	1.24e-04	1497	56	10	31527615
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	LMTK3 CIC	2.29e-04	14	56	2	28263302
Pubmed	Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.	CGREF1 UNC5CL CLIC6 KHSRP	2.91e-04	197	56	4	21386911
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	AKAP13 KIF7	3.83e-04	18	56	2	26921296
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ARHGEF5 EMG1 CHD6 CHD1L CIC DNMT3A	4.31e-04	608	56	6	36089195
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	TRIM33 NFKB1 CHD1L PUM1 CIC KHSRP KIF7	4.37e-04	857	56	7	25609649
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	DRD3 FSD2 CHD1L MTUS2 MRTFA	4.74e-04	402	56	5	24722188
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	COL6A1 NAV1 CHD6 CIC MRTFA	5.65e-04	418	56	5	34709266
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	PUM1 KIF7 SPICE1	5.89e-04	101	56	3	24613305
Pubmed	Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.	MOG DNMT3A	6.87e-04	24	56	2	27149841
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	LIMD1 NAV1 PUM1 KIF7 SPICE1	7.57e-04	446	56	5	24255178
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	NFKB1 LMTK3 MRTFA RUSC2	7.91e-04	257	56	4	30945288
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TRIM33 ZSWIM9 NFKB1 AKAP13 CIC DNMT3A	8.28e-04	689	56	6	36543142
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	CHD6 MRTFA	8.71e-04	27	56	2	17525332
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CHD6 LMTK3 MTUS2 MOG KHSRP	1.00e-03	475	56	5	31040226
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MAPRE1 LIMD1 SRP68 AKAP13 PUM1 KHSRP	1.07e-03	724	56	6	36232890
Pubmed	A genetic linkage map of the mouse: current applications and future prospects.	DRD3 NFKB1	1.08e-03	30	56	2	8211130
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MAPRE1 NAV1 SRP68 AKAP13 CHD6 PUM1	1.14e-03	733	56	6	34672954
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	THBS4 CREBZF	1.15e-03	31	56	2	31550482
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SPTBN4 NAV1 PDZD2	1.22e-03	130	56	3	12421765
Pubmed	Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.	COL6A1 NFKB1	1.46e-03	35	56	2	16452166
Pubmed	Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.	ZNF469 AKAP13	1.46e-03	35	56	2	23291589
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF35 ARHGEF5 AKAP13	2.56e-04	66	34	3	722
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	MAPRE1 ZNF469 CHD6 DNMT3A RUSC2	3.88e-06	188	56	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
Disease	corneal topography	COL6A1 ZNF469 THBS4 AKAP13	4.16e-05	109	52	4	EFO_0004345
Disease	corneal hysteresis	COL6A1 ZNF469	5.67e-04	20	52	2	EFO_0010066
Disease	eye measurement	ZNF469 AKAP13	1.04e-03	27	52	2	EFO_0004731
Disease	lymphocyte percentage of leukocytes	NFKB1 KHNYN NLRC5 MRTFA DNMT3A SP140	1.08e-03	665	52	6	EFO_0007993
Disease	lymphocyte measurement	NFKB1 KHNYN NLRC5	1.17e-03	117	52	3	EFO_0803546
Disease	corneal resistance factor	COL6A1 ZNF469 THBS4 AKAP13 CIC	1.17e-03	451	52	5	EFO_0010067
Disease	psoriasis	NFKB1 AKAP13 CLIC6 RUSC2	1.37e-03	273	52	4	EFO_0000676

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPMAGGDKDDGFDRR	AMIGO1	426	Q86WK6
EGRGAPAEAGKEQKE	DNMT3A	141	Q9Y6K1
GEDGRNNSGAPHREK	ACBD5	381	Q5T8D3
ERKAQGQGGPEQGEE	ARHGEF5	311	Q12774
GQGGPEQGEERKREL	ARHGEF5	316	Q12774
GGEKEEGDDGQDLRR	AKAP13	2481	Q12802
DGEGRPAKSQEEGKR	CCDC96	186	Q2M329
ERKAQGQGGPEQGEE	ARHGEF35	311	A5YM69
GQGGPEQGEERKREL	ARHGEF35	316	A5YM69
EFGNDKAREPSVGGR	AQP8	11	O94778
PRGEAEGQAEAKGDA	CGREF1	221	Q99674
RADAGEDRVGDGPQQ	CLIC6	351	Q96NY7
GNCEEKRGVNPGEQD	MTUS2	376	Q5JR59
RRQEKSAGDADPENG	ELOA2	656	Q8IYF1
DGLFRVDKGAGNNPE	LIMD1	26	Q9UGP4
QDPGDSQKKRGEARG	GPR179	1281	Q6PRD1
NGDQRAPGIEEKAAE	LMTK3	931	Q96Q04
PNGSAAEDGRLKEGD	PDZD2	621	O15018
DQAAQGAGGRKEDEG	KIF7	471	Q2M1P5
RNGKDQDGDQAPEYR	MOG	81	Q16653
RAPDLQESDGQRKGA	NLRC5	826	Q86WI3
RKGGFGPRDADSDEN	PUM1	236	Q14671
SAGEQAAGDPEGRRQ	PANK2	146	Q9BZ23
ALDDQDDGRRKPGIG	CD99L2	76	Q8TCZ2
GDDNNDIAPRGVKGA	COL6A1	556	P12109
PGDQEGAAKGSKDRE	CHD6	101	Q8TD26
APQGKRRKADGEDAG	DDX51	86	Q8N8A6
PAAEGGSRDQEEGKN	CHD1L	556	Q86WJ1
RKNPGVGNGDDEAAE	MAPRE1	181	Q15691
GIRGGDPEDNDIREK	MAN1A2	166	O60476
CGDRGDVGDRGDKQQ	KHNYN	376	O15037
PGKRDGEGQEQGKED	CCDC168	4376	Q8NDH2
AGEGRNQQKLRGEDD	GOLM1	336	Q8NBJ4
SGDEGSPQRREKANG	MAP3K9	611	P80192
GPGFQERGGELKREE	DRD3	266	P35462
DEGADEPRGAGRKAA	NAV1	21	Q8NEY1
GGQKRQLEDGDQPES	KHSRP	106	Q92945
ARGQEGPGDVDRAAQ	RUSC2	1211	Q8N2Y8
GPGDVDRAAQGERVK	RUSC2	1216	Q8N2Y8
SARIGGDGNNKDDDP	TRIM33	871	Q9UPN9
LDQARQPGDRGEGET	ABCC6	851	O95255
RGAGDGKAQRDLQEE	FSD2	56	A1L4K1
DRQQGAGEPGRADKD	SHISA2	91	Q6UWI4
SPGGRAELEGRDKDQ	MRTFA	511	Q969V6
RGAGGEENKENERPS	SRP68	31	Q9UHB9
EPRGEQGDGLRELNK	SPICE1	691	Q8N0Z3
NKEEQEGGGARVPSA	CIC	636	Q96RK0
PNRDQRDKDGDGVGD	THBS4	586	P35443
DEPGRGAQGENERVR	ZSWIM9	456	Q86XI8
VDGADRDEKDFRNPG	ZSCAN32	381	Q9NX65
EGGQEAAAPARQGRK	IGHMBP2	681	P38935
KGQRGGAARPADQET	SERINC4	396	A6NH21
PERGGARDNQGLELD	UNC5CL	501	Q8IV45
PGRKQQFGDEGELEA	CREBZF	51	Q9NS37
DEGNPKREGGDRRAS	SPTBN4	2546	Q9H254
DGFKPRERSGGEQAQ	EMG1	6	Q92979
GDAQAEGKDDPLRTG	ZNF469	801	Q96JG9
RKAARQEAGGDGAPA	ZNF469	1111	Q96JG9
GEKQGEEEGRNSPRK	SP140	266	Q13342
APKRGEEGDQAGRLD	THAP10	96	Q9P2Z0
EGGGDRQLGDREKEL	NFKB1	181	P19838