Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	chromatin organization	RBM15 OGT BRCA2 ASF1B ASIP TET1 ZFP57 NAP1L2 MECOM CHD6 TP53BP1 BAHCC1 TDRD12	3.01e-07	896	53	13	GO:0006325
GeneOntologyBiologicalProcess	protein-DNA complex organization	RBM15 OGT BRCA2 ASF1B ASIP TET1 ZFP57 NAP1L2 MECOM CHD6 TP53BP1 BAHCC1 TDRD12	1.03e-06	999	53	13	GO:0071824
GeneOntologyBiologicalProcess	epigenetic programming in the zygotic pronuclei	ASIP TET1 ZFP57	1.06e-05	17	53	3	GO:0044725
GeneOntologyBiologicalProcess	chromatin remodeling	RBM15 BRCA2 ASF1B ASIP TET1 ZFP57 NAP1L2 MECOM CHD6 TDRD12	1.62e-05	741	53	10	GO:0006338
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	HOXA9 RBM15 HOXB9 OGT ZNF33B WNT1 TET1 PEG3 LPIN2 MECOM CHD6 TP53BP1 MEOX1	3.71e-05	1390	53	13	GO:0045944
GeneOntologyBiologicalProcess	hematopoietic stem cell proliferation	BRCA2 WNT1 MECOM	1.84e-04	43	53	3	GO:0071425
Domain	HXA9/HXB9/HXC9	HOXA9 HOXB9	4.55e-05	4	52	2	IPR017112
Domain	Hox9_act	HOXA9 HOXB9	4.55e-05	4	52	2	PF04617
Domain	Hox9_activation_N	HOXA9 HOXB9	4.55e-05	4	52	2	IPR006711
Domain	ERAP1-like_C_dom	TRHDE ENPEP	2.11e-04	8	52	2	IPR024571
Domain	ERAP1_C	TRHDE ENPEP	2.11e-04	8	52	2	PF11838
Domain	Peptidase_M1	TRHDE ENPEP	4.93e-04	12	52	2	IPR001930
Domain	Peptidase_M1	TRHDE ENPEP	5.82e-04	13	52	2	PF01433
Domain	Peptidase_M1_N	TRHDE ENPEP	5.82e-04	13	52	2	IPR014782
Domain	HTH_motif	HOXA9 HOXB9 MEOX1	9.37e-04	69	52	3	IPR000047
Domain	Nucleotide_cyclase	ADCY10 ADCY4	1.13e-03	18	52	2	IPR029787
Domain	-	ADCY10 ADCY4	1.13e-03	18	52	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY10 ADCY4	1.26e-03	19	52	2	PS00452
Domain	Guanylate_cyc	ADCY10 ADCY4	1.26e-03	19	52	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY10 ADCY4	1.26e-03	19	52	2	PS50125
Domain	A/G_cyclase	ADCY10 ADCY4	1.26e-03	19	52	2	IPR001054
Domain	CYCc	ADCY10 ADCY4	1.26e-03	19	52	2	SM00044
Domain	Homeobox_metazoa	HOXA9 HOXB9 MEOX1	2.02e-03	90	52	3	IPR020479
Pubmed	Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells.	OGT TET1	2.28e-06	2	53	2	23729667
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EPS15 OGT BRCA2 TET1 NAV1 MECOM CHD6	3.30e-06	418	53	7	34709266
Pubmed	Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence.	HOXA9 HOXB9 MEOX1	4.36e-06	21	53	3	22675207
Pubmed	Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.	HK2 BRCA2	6.83e-06	3	53	2	25176644
Pubmed	GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6.	HOXB9 WNT1	6.83e-06	3	53	2	31310747
Pubmed	53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice.	BRCA2 TP53BP1	6.83e-06	3	53	2	32139898
Pubmed	Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models.	OGT TET1	6.83e-06	3	53	2	34685658
Pubmed	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.	HOXA9 TET1	6.83e-06	3	53	2	23716660
Pubmed	Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development.	EPS15 WNT1	6.83e-06	3	53	2	7566980
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	BRCA2 CHD6 TP53BP1	9.52e-06	27	53	3	17525332
Pubmed	Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).	OGT TET1	1.36e-05	4	53	2	24394411
Pubmed	Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.	OGT TET1	1.36e-05	4	53	2	23352454
Pubmed	Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.	HOXA9 HOXB9	1.36e-05	4	53	2	9892669
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	OGT TET1	1.36e-05	4	53	2	25568311
Pubmed	Interaction network of human early embryonic transcription factors.	HOXB9 OGT TET1 MECOM AHDC1 BAHCC1	1.56e-05	351	53	6	38297188
Pubmed	Association of β-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 with the prognosis of esophageal squamous cell carcinoma.	HOXA9 WNT1	2.27e-05	5	53	2	21259057
Pubmed	Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.	BRCA2 TP53BP1	2.27e-05	5	53	2	38244928
Pubmed	Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer.	OGT HK2	2.27e-05	5	53	2	20845477
Pubmed	Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions.	HOXA9 HOXB9	2.27e-05	5	53	2	9013929
Pubmed	PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.	OGT TET1	2.27e-05	5	53	2	34667079
Pubmed	Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.	HOXA9 HOXB9 MEOX1	3.17e-05	40	53	3	28009287
Pubmed	TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator.	OGT TET1	3.40e-05	6	53	2	25517638
Pubmed	BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks.	BRCA2 TP53BP1	3.40e-05	6	53	2	38554279
Pubmed	BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.	BRCA2 TP53BP1	3.40e-05	6	53	2	38696471
Pubmed	K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.	EPS15 CORO7	4.76e-05	7	53	2	24768539
Pubmed	Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.	BRCA2 TP53BP1	4.76e-05	7	53	2	19626602
Pubmed	Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.	WNT1 MEOX1	4.76e-05	7	53	2	16540515
Pubmed	Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos.	HOXB9 MEOX1	4.76e-05	7	53	2	9694798
Pubmed	High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.	WNT1 MEOX1	4.76e-05	7	53	2	9799734
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	RBM15 HOXB9 ASF1B NAV1 MECOM CHD6 MED13L	5.37e-05	645	53	7	25281560
Pubmed	Wnt-3a regulates somite and tailbud formation in the mouse embryo.	WNT1 MEOX1	6.34e-05	8	53	2	8299937
Pubmed	53BP1 promotes ATM activity through direct interactions with the MRN complex.	BRCA2 TP53BP1	6.34e-05	8	53	2	20010693
Pubmed	Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.	BRCA2 TP53BP1	8.15e-05	9	53	2	23657012
Pubmed	Chromosomal localization of acquired MMTV proviral integration sites in T-cell lymphomas.	WNT1 MECOM	8.15e-05	9	53	2	9434954
Pubmed	BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.	BRCA2 TP53BP1	8.15e-05	9	53	2	30704900
Pubmed	Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias.	HOXA9 MECOM	1.24e-04	11	53	2	8563752
Pubmed	Mitochondrial retention of Opa1 is required for mouse embryogenesis.	HOXB9 WNT1	1.24e-04	11	53	2	20652258
Pubmed	Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice.	WNT1 MEOX1	1.24e-04	11	53	2	10589677
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	OGT TET1 BAHCC1	1.30e-04	64	53	3	22865885
Pubmed	Notch1 is required for the coordinate segmentation of somites.	HOXB9 MEOX1	1.49e-04	12	53	2	7789282
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	AHDC1 TP53BP1	1.49e-04	12	53	2	28700933
Pubmed	Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.	HOXB9 MEOX1	1.49e-04	12	53	2	9435295
Pubmed	Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape.	HOXA9 HOXB9	1.49e-04	12	53	2	27856734
Pubmed	Role of Tet1 in erasure of genomic imprinting.	TET1 PEG3	1.49e-04	12	53	2	24291790
Pubmed	Axial Hox9 activity establishes the posterior field in the developing forelimb.	HOXA9 HOXB9	1.49e-04	12	53	2	21383175
Pubmed	NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.	BRCA2 CHD6	1.76e-04	13	53	2	28416489
Pubmed	Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.	HOXB9 MEOX1	1.76e-04	13	53	2	20941375
Pubmed	The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.	BRCA2 TP53BP1	1.76e-04	13	53	2	29499138
Pubmed	Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development.	HOXA9 HOXB9	1.76e-04	13	53	2	24525295
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY10 ADCY4	2.05e-04	14	53	2	14993377
Pubmed	Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos.	HOXB9 MEOX1	2.36e-04	15	53	2	9334279
Pubmed	Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis.	HOXB9 MEOX1	2.36e-04	15	53	2	18304314
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	OGT HK2 TET1 TP53BP1	2.64e-04	203	53	4	22083510
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM15 OGT BRCA2 NAV1 MECOM TP53BP1	2.66e-04	588	53	6	38580884
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY4 USH2A	2.70e-04	16	53	2	17567809
Pubmed	Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development.	HOXB9 MEOX1	2.70e-04	16	53	2	10191046
Pubmed	A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.	HOXA9 HOXB9	2.70e-04	16	53	2	31747609
Pubmed	Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.	HOXB9 MEOX1	2.70e-04	16	53	2	18332127
Pubmed	Hox genes and the evolution of vertebrate axial morphology.	HOXA9 HOXB9	2.70e-04	16	53	2	7768176
Pubmed	MicroRNA-140 plays dual roles in both cartilage development and homeostasis.	ASPN MEOX1	3.05e-04	17	53	2	20466812
Pubmed	Hox patterning of the vertebrate rib cage.	HOXA9 HOXB9	3.05e-04	17	53	2	17626057
Pubmed	PEG3 control on the mammalian MSL complex.	HOXB9 PEG3	3.43e-04	18	53	2	28609438
Pubmed	The HOX homeodomain proteins block CBP histone acetyltransferase activity.	HOXA9 HOXB9	3.43e-04	18	53	2	11585930
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CCNG2 SEMA4D EPS15 OGT ZNF33B FRMPD1 NAV1 CHD6 AHDC1	3.81e-04	1489	53	9	28611215
Pubmed	Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.	OGT TET1	3.83e-04	19	53	2	22984288
Pubmed	Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.	OGT TET1	3.83e-04	19	53	2	28554894
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PEG3 FRMPD1 NAV1 CHD6 MED13L	3.87e-04	407	53	5	12693553
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	SEMA4D PLB1 SOCS4 MECOM AHDC1	4.01e-04	410	53	5	25814554
Pubmed	PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.	OGT NAV1	4.25e-04	20	53	2	32079660
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	WNT1 MEOX1	4.70e-04	21	53	2	9449667
Pubmed	Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.	HOXA9 HOXB9	5.65e-04	23	53	2	28041967
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	NAV1 CHD6 AHDC1	6.26e-04	109	53	3	33554859
Pubmed	Directed differentiation of telencephalic precursors from embryonic stem cells.	HOXB9 WNT1	6.68e-04	25	53	2	15696161
Pubmed	ZFP57 dictates allelic expression switch of target imprinted genes.	PEG3 ZFP57	6.68e-04	25	53	2	33500348
Pubmed	A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.	CCNG2 TP53BP1	6.68e-04	25	53	2	21536733
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	BRCA2 TP53BP1	6.68e-04	25	53	2	32737294
Pubmed	Fine mapping of human HOX gene clusters.	HOXA9 HOXB9	7.23e-04	26	53	2	8646877
Pubmed	Neural induction and patterning in the mouse in the absence of the node and its derivatives.	HOXB9 WNT1	7.23e-04	26	53	2	10642791
Pubmed	Global gene expression analysis of murine limb development.	HOXA9 PEG3 ZFP57	7.69e-04	117	53	3	22174793
Pubmed	The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.	ASIP MECOM	7.80e-04	27	53	2	8390965
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	BRCA2 TET1	7.80e-04	27	53	2	23395962
Pubmed	TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.	TET1 MEOX1	8.40e-04	28	53	2	27760115
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	EPS15 NAV1 MECOM CEP295 CHD6 CORO7	8.49e-04	733	53	6	34672954
Pubmed	The human HOX gene family.	HOXA9 HOXB9	9.01e-04	29	53	2	2574852
Pubmed	The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.	ASIP CORO7	9.01e-04	29	53	2	12438443
Pubmed	A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.	WNT1 MEOX1	9.01e-04	29	53	2	33567267
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	OGT ASF1B TET1 NSL1 AHDC1	9.36e-04	495	53	5	27705803
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	RBM15 TRAF4 PLB1 SLC12A4 BRCA2 CHD6	9.83e-04	754	53	6	35906200
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	BRCA2 TP53BP1	1.03e-03	31	53	2	19690177
Pubmed	Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.	HOXA9 HOXB9	1.10e-03	32	53	2	17535249
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	BRCA2 TET1	1.10e-03	32	53	2	27739607
Pubmed	Ndrg2 regulates vertebral specification in differentiating somites.	HOXA9 HOXB9	1.10e-03	32	53	2	22819676
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXA9 HOXB9	1.10e-03	32	53	2	37167859
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	WNT1 MEOX1	1.17e-03	33	53	2	32439762
Pubmed	Global control of motor neuron topography mediated by the repressive actions of a single hox gene.	HOXA9 HOXB9	1.39e-03	36	53	2	20826310
Pubmed	Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.	WNT1 ASIP	1.39e-03	36	53	2	6690234
Pubmed	Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.	WNT1 ASIP	1.39e-03	36	53	2	8094303
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	BRCA2 TP53BP1	1.47e-03	37	53	2	19116388
Interaction	MALRD1 interactions	MALRD1 CEP295	6.53e-06	2	52	2	int:MALRD1
Interaction	SCAI interactions	OGT NSL1 AHDC1 TP53BP1	1.73e-05	60	52	4	int:SCAI
Interaction	UBQLN3 interactions	EPS15 BRCA2	1.96e-05	3	52	2	int:UBQLN3
Interaction	PHF21A interactions	EPS15 OGT BRCA2 TET1 NAV1 MECOM CHD6	2.70e-05	343	52	7	int:PHF21A
Interaction	RBBP7 interactions	OGT BRCA2 ASF1B TET1 TBC1D2 USP43 MECOM BAHCC1	4.32e-05	507	52	8	int:RBBP7
Cytoband	Xq13	OGT NAP1L2	1.01e-04	13	53	2	Xq13
GeneFamily	HOXL subclass homeoboxes	HOXA9 HOXB9 MEOX1	1.63e-04	52	37	3	518
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY10 ADCY4	1.81e-04	10	37	2	53
GeneFamily	Tudor domain containing	TP53BP1 TDRD12	2.59e-03	37	37	2	780
Coexpression	GSE10240_CTRL_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN	HOXA9 HK2 TET1 LPIN2 TP53BP1 BAHCC1	2.48e-06	200	51	6	M304
Coexpression	GRESHOCK_CANCER_COPY_NUMBER_UP	HOXA9 EPS15 RBM15 BRCA2 TET1 MECOM	3.78e-05	323	51	6	M9150
Coexpression	GSE8515_CTRL_VS_IL6_4H_STIM_MAC_DN	MECOM CORO7 USH2A ENPEP BAHCC1	3.85e-05	195	51	5	M5765
CoexpressionAtlas	kidney_P3_CapMes_Crym_top-relative-expression-ranked_500	HOXA9 HOXB9 ASPN LPIN2 MECOM ENPEP MEOX1	2.42e-05	370	50	7	gudmap_kidney_P3_CapMes_Crym_500
ToppCell	CV-Severe-3\|CV / Virus stimulation, Condition and Cluster	HOXA9 SEMA4D BRCA2 ASF1B WNT1	2.41e-06	184	52	5	1c9bda00bb6efd98f68781ca06655bf6c4282f27
ToppCell	CV-Severe-3\|Severe / Virus stimulation, Condition and Cluster	HOXA9 SEMA4D BRCA2 ASF1B WNT1	2.61e-06	187	52	5	68cb43a73945f5e252530da25613f6b3f484b4d5
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TRHDE BRCA2 SOCS4 USH2A ZNF774	3.62e-06	200	52	5	fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell	MS-CD8-memory_CD4\|MS / Condition, Cell_class and T cell subcluster	SLC12A4 TET1 TBC1D2 TDRD12	3.14e-05	154	52	4	aec893cf3e1cf90e18a9117183fc7a1f397425a9
ToppCell	CV-Mild-4\|Mild / Virus stimulation, Condition and Cluster	HOXA9 CCNG2 HK2 NAP1L2	3.65e-05	160	52	4	2e24f8de5086b086863d3bf4d9afbd9bc93f4d5e
ToppCell	CV-Mild-4\|CV / Virus stimulation, Condition and Cluster	HOXA9 CCNG2 HK2 NAP1L2	3.65e-05	160	52	4	be89efeeecb0de96ce136a7a62738f15dc0badb2
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP ASF1B MEOX1 TDRD12	4.52e-05	169	52	4	1558606be0a8bcd4fd0ce609701a1411e4ca2f9f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RBM15 BRCA2 ASF1B CEP295	4.52e-05	169	52	4	b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP ASF1B MEOX1 TDRD12	4.52e-05	169	52	4	1b2354de1ce4080118d9f01e7c5fd6079e705125
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXA9 BRCA2 ASF1B NSL1	4.73e-05	171	52	4	1efce222989460bb59bd9fa955e7d9a60c73994c
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	TRHDE HOXA9 MECOM BAHCC1	4.84e-05	172	52	4	a66402d15853f0c9e3d06394ff9ac08d1da128ff
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_MEMP\|lymph-node_spleen / Manually curated celltypes from each tissue	TRHDE HOXA9 MALRD1 MECOM	5.29e-05	176	52	4	23a8ec42ebd42c539865a12d09773af90f3f8848
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADCY4 HOXB9 MECOM MEOX1	5.77e-05	180	52	4	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRHDE ADCY4 HOXB9 MECOM	6.42e-05	185	52	4	62cfcb0e2a9e6718e6b200dfbb1a81eaead229b5
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLC12A4 TET1 CEP295 CORO7	6.83e-05	188	52	4	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	Monocytes-Tissue-resident_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CHRNA6 FCGBP HK2 NAV1	7.12e-05	190	52	4	07215e8f292cb54c670037aaf28393cddbe5548c
ToppCell	(01)_Dendritic_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	HOXA9 TRAF4 ASIP NAV1	7.27e-05	191	52	4	1f4c8078e1a6cd14937c714330af608caced2acf
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	CHRNA6 FCGBP HK2 LPIN2	7.56e-05	193	52	4	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA9 ASPN PEG3 ENPEP	8.19e-05	197	52	4	2744cc94883c5d0424677cf5093bbab622933e9b
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 HOXB9 ASPN TRIM38	8.19e-05	197	52	4	488e85991c5e668afb7672942726d9295b8fc7d8
Disease	alpha fetoprotein measurement	SEMA4D TET1 USP43 TP53BP1	2.54e-05	100	50	4	EFO_0010583
Disease	obesity (implicated_via_orthology)	WNT1 ASIP LPIN2 MED13L CORO7	3.18e-05	215	50	5	DOID:9970 (implicated_via_orthology)
Disease	ovarian neoplasm	HOXB9 BRCA2 MECOM TP53BP1	7.96e-05	134	50	4	C0919267
Disease	Malignant neoplasm of ovary	HOXB9 BRCA2 MECOM TP53BP1	8.68e-05	137	50	4	C1140680
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	BRCA2 ASIP MECOM	9.54e-05	52	50	3	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	pulse pressure measurement	HOXA9 MALRD1 ZNF33B TET1 NAV1 MED13L CORO7 ENPEP AHDC1	4.91e-04	1392	50	9	EFO_0005763
Disease	remission, hepatitis C virus infection	MALRD1 ASIP	6.96e-04	23	50	2	EFO_0003047, EFO_0009785
Disease	Pancytopenia	BRCA2 MECOM	8.91e-04	26	50	2	C0030312
Disease	hypertension, COVID-19	MECOM ENPEP	9.61e-04	27	50	2	EFO_0000537, MONDO_0100096
Disease	cardiovascular disease	PLB1 NAV1 MECOM ENPEP BAHCC1	1.04e-03	457	50	5	EFO_0000319
Disease	cutaneous melanoma	ASIP MED13L CORO7	1.15e-03	121	50	3	EFO_0000389
Disease	intracranial volume measurement	CCNG2 MECOM	1.44e-03	33	50	2	EFO_0004886
Disease	Malignant neoplasm of urinary bladder	HOXA9 BRCA2 CHD6	1.78e-03	141	50	3	C0005684
Disease	aortic stenosis, aortic valve calcification	NAV1 MECOM	2.32e-03	42	50	2	EFO_0000266, EFO_0005239

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFSPTHARKAFPCFD	TRHDE	266	Q9UKU6
FPLPYDSDCHSSFSD	BAHCC1	2311	Q9P281
SPPSDQECTFFFNFK	CCNG2	321	Q16589
SLFFFPTSSDCPFQA	ADCY4	681	Q8NFM4
SPPDKAFSTHAFSEN	AHDC1	46	Q5TGY3
PPNFNFDEFFTKCTT	ADCY10	221	Q96PN6
ALCSAKPFFSPSHIA	ASPN	11	Q9BXN1
CFFTANSHLPPEEKL	ASIP	16	P42127
HAFPPCEFSQQFLDS	RBM15	921	Q96T37
PKDSFFNFFSPHGIT	NAP1L2	366	Q9ULW6
TPFSFHQKPDFLATA	MEOX1	41	P50221
DHQKFPCSTPHSAFS	MECOM	226	Q03112
FSSCHRKPDAKPENF	NSL1	221	Q96IY1
NPEDSAPSSFCKFFK	NXF3	381	Q9H4D5
PVNKSEHLSCAFTFF	MED13L	156	Q71F56
IDCFSESKHTEPSFP	KIAA2026	971	Q5HYC2
GFTFSFPCHQTKLDE	HK2	151	P52789
FFLECNSFTSPDPHK	CORO7	766	P57737
AEHPDFSPCSFQSKA	HOXA9	46	P31269
DHEPTDARKSFPCFD	ENPEP	221	Q07075
PKCGESFIHSSFLFE	PEG3	1166	Q9GZU2
HAEHLEFPSCSFQPK	HOXB9	41	P17482
CHIKFNPPATDFTYA	MALRD1	2056	Q5VYJ5
DITFFPFDHQNCSLK	CHRNA6	161	Q15825
SPFHSPFRFEISFEC	ASF1B	16	Q9NVP2
HFSKFLDPDFQPSCS	BRCA2	3056	P51587
ASVNFDYKSPSPFDC	CHD6	26	Q8TD26
FTTCHAHVPPESFFK	FCGBP	4291	Q9Y6R7
AEKSFLCFAPESHPE	FRMPD1	1291	Q5SYB0
DPFASDCFFRQSTDP	EPS15	651	P42566
SFFGSPLAHDPFSCL	CEP295	1886	Q9C0D2
HNPDKFEVFCYALSP	OGT	581	O15294
HFFCDSPPLFKLSCS	OR5F1	176	O95221
EKHSTSDFLIGPCFF	NAV1	1731	Q8NEY1
SFIFGNHKSCFSSPP	USH2A	126	O75445
SKSCHYNISVDPFPF	USH2A	581	O75445
GCHIFTFPKASFSDT	TRIM38	431	O00635
DATCVIHFSFPASPK	TDRD12	746	Q587J7
NFSFDAHDPCVFHSP	SOCS4	341	Q8WXH5
FQPACDHLNLTSFKF	SEMA4D	131	Q92854
EGLPDNSFFAPDCFH	PLB1	641	Q6P1J6
NSFFAPDCFHFSSKS	PLB1	646	Q6P1J6
FFCHSPNLTTDSCDP	SLC12A4	341	Q9UP95
FCPHDFPTVFGKISS	TET1	1201	Q8NFU7
TSFPKSCDNFNLLHP	UHRF1BP1L	641	A0JNW5
TCPHCLKQSNTFDPF	USP43	251	Q70EL4
QIPPSKDSHYEFSDC	ZNF33B	266	Q06732
PPNYCFHCSKSFSSF	ZFP57	326	Q9NU63
DKFPQTKTSPYCSFH	SPEM3	531	A0A1B0GUW6
PHAKDSFSSNFVPSD	SPATA31D1	361	Q6ZQQ2
PFSCPDCHKSFSQSS	ZNF774	346	Q6NX45
CESSSETPFHFTLPK	TP53BP1	896	Q12888
AKPNLECFSPAFYTH	TRAF4	326	Q9BUZ4
PHDLVYFEKSPNFCT	WNT1	286	P04628
SFFPHSGKDCLLCFP	ZHX1-C8orf76	171	Q96EF9
NKHFTCPTSSFPDKL	TBC1D2	681	Q9BYX2
KEQNSAFPCPEFSSF	LPIN2	866	Q92539