Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24	3.16e-10	37	153	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24	3.98e-10	38	153	8	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.05e-06	11	153	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	3.12e-06	14	153	4	GO:0003964
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	4.36e-06	5	153	3	GO:0030156
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 SMARCA5 POLA1 CHD8 BTAF1 ERVK-7 ERVK-10 RECQL4 ERVK-8 SMARCA1 CHD6	5.81e-06	262	153	11	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA5 CHD8 BTAF1 SMARCA1 CHD6	8.85e-06	37	153	5	GO:0140658
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 POLA1 ERVK-7 ERVK-10 ERVK-8	1.01e-05	38	153	5	GO:0034061
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.79e-05	21	153	4	GO:0035613
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 POLA1 KDM5C TRIM71 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ECE1 AOPEP RECQL4 ERVK-8 ERVK-5 ERVK-19 KDM1B DMD ERVK-24 RABGGTA	1.66e-04	891	153	18	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.80e-04	37	153	4	GO:0016891
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 DNAH3 SMARCA5 ABCC5 CHD8 BTAF1 ATP6V0D1 STARD9 RECQL4 SMARCA1 MYH15 CHD6 ATP6V0D2 KIF13A	2.75e-04	614	153	14	GO:0140657
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 DNAH3 STARD9 MYH15 KIF13A MYO16	2.98e-04	118	153	6	GO:0003774
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-8	4.21e-04	46	153	4	GO:0016893
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	4.43e-04	127	153	6	GO:0008094
GeneOntologyMolecularFunction	protein-arginine deiminase activity	PADI4 PADI1	5.75e-04	5	153	2	GO:0004668
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	5.75e-04	5	153	2	GO:0140444
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 EXOSC10 POLRMT ERVK-7 ERVK-10 ERVK-8	6.36e-04	136	153	6	GO:0004540
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	8.34e-04	55	153	4	GO:0042974
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM1B	8.57e-04	6	153	2	GO:0034647
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 POLA1 POLRMT ERVK-7 ERVK-10 ERVK-8	1.14e-03	152	153	6	GO:0016779
GeneOntologyMolecularFunction	helicase activity	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	1.38e-03	158	153	6	GO:0004386
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-6 EXOSC10 SMARCA5 POLA1 POLRMT CHD8 BTAF1 ERVK-7 ERVK-10 RECQL4 ERVK-8 SMARCA1 CHD6	1.42e-03	645	153	13	GO:0140640
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM1B	1.58e-03	8	153	2	GO:0032453
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 USP28 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ECE1 FAP AOPEP ERVK-8 ERVK-19 ERVK-24 ZRANB1	1.60e-03	654	153	13	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ECE1 FAP ERVK-8 ERVK-19 ERVK-24	1.80e-03	430	153	10	GO:0004175
GeneOntologyMolecularFunction	cytoskeletal protein binding	SYNE1 SPTBN2 ARFGEF2 MAST2 OPA1 SPTBN4 EML5 STARD9 SYNE2 TAGLN3 CLTC MYH15 MTCL1 FHDC1 GNAS DMD KIF13A MYO16	1.91e-03	1099	153	18	GO:0008092
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 DNAH3 STARD9 KIF13A	2.05e-03	70	153	4	GO:0003777
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 EXOSC10 POLRMT ERVK-7 ERVK-10 ERVK-8 LAS1L	2.06e-03	231	153	7	GO:0004518
GeneOntologyBiologicalProcess	cellular process involved in reproduction in multicellular organism	DNHD1 PRAMEF5 TCP11X2 MAST2 CEP128 RIMBP3 FANCG MEIOC MTOR RIMBP3C CFAP70 GNAS KDM1B RIMBP3B PRAMEF11 PRAMEF6	1.54e-06	527	150	16	GO:0022412
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.83e-06	13	150	4	GO:0015074
GeneOntologyBiologicalProcess	germ cell development	DNHD1 PRAMEF5 TCP11X2 CEP128 RIMBP3 FANCG MEIOC MTOR RIMBP3C CFAP70 GNAS KDM1B RIMBP3B PRAMEF11 PRAMEF6	2.47e-06	482	150	15	GO:0007281
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 SMARCA5 POLA1 POLRMT WDR18 ERVK-7 ERVK-10 NFIA NFIX RECQL4 TONSL ERVK-8	3.12e-06	312	150	12	GO:0006260
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-6 POLA1 POLRMT WDR18 ERVK-7 ERVK-10 RECQL4 TONSL ERVK-8	6.34e-06	178	150	9	GO:0006261
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 POLA1 ERVK-7 ERVK-10 ERVK-8	2.53e-05	48	150	5	GO:0000731
GeneOntologyBiologicalProcess	spermatid differentiation	DNHD1 TCP11X2 MAST2 CEP128 RIMBP3 FANCG MEIOC RIMBP3C CFAP70 RIMBP3B	3.12e-05	272	150	10	GO:0048515
GeneOntologyBiologicalProcess	multicellular organism growth	SPTBN2 POU1F1 POU3F2 SPTBN4 MTOR NFIX GNAS DMD RASAL2	8.92e-05	249	150	9	GO:0035264
GeneOntologyBiologicalProcess	spermatid development	DNHD1 TCP11X2 CEP128 RIMBP3 FANCG MEIOC RIMBP3C CFAP70 RIMBP3B	1.31e-04	262	150	9	GO:0007286
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C CFAP70 RIMBP3B	4.21e-05	28	147	4	GO:0002177
GeneOntologyCellularComponent	plasma membrane proton-transporting V-type ATPase complex	ATP6V0D1 ATP6V0D2	4.91e-05	2	147	2	GO:0033181
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	3.31e-04	47	147	4	GO:0031462
HumanPheno	Limited elbow movement	TBX15 SFRP4 SYNE1 MAP3K20 PIK3C2A SYNE2 RECQL4 TONSL DMD	1.73e-05	168	47	9	HP:0002996
HumanPheno	Type 1 muscle fiber atrophy	SYNE1 MAP3K20 SPTBN4 SYNE2	1.77e-05	18	47	4	HP:0011807
HumanPheno	Abnormality of lower limb joint	TBX15 SFRP4 SYNE1 KDM5C SPTBN2 MAP3K20 POLRMT ARFGEF2 POU1F1 POU3F4 SPG11 ECE1 SPTBN4 FANCG ARSL PIK3C2A NFIX SCN1A RECQL4 TONSL GNAS DMD	3.31e-05	1027	47	22	HP:0100491
MousePheno	megacephaly	TRIM71 CHD8 ADGRA2 NFIX SMARCA1	1.75e-06	25	117	5	MP:0000434
Domain	Spectrin	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	7.65e-07	23	144	5	PF00435
Domain	ACTININ_2	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	7.65e-07	23	144	5	PS00020
Domain	ACTININ_1	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	7.65e-07	23	144	5	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	7.65e-07	23	144	5	IPR001589
Domain	TF_POU_3	POU3F1 POU3F2 POU3F4	1.79e-06	4	144	3	IPR016362
Domain	Spectrin_repeat	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	2.60e-06	29	144	5	IPR002017
Domain	SNF2_N	SMARCA5 CHD8 BTAF1 SMARCA1 CHD6	4.33e-06	32	144	5	IPR000330
Domain	SNF2_N	SMARCA5 CHD8 BTAF1 SMARCA1 CHD6	4.33e-06	32	144	5	PF00176
Domain	SPEC	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	4.33e-06	32	144	5	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 SPTBN2 SPTBN4 SYNE2 DMD	4.33e-06	32	144	5	IPR018159
Domain	POU	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	SM00352
Domain	POU_dom	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	IPR000327
Domain	Pou	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	PF00157
Domain	POU_1	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	PS00035
Domain	POU_2	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	PS00465
Domain	POU_3	POU1F1 POU3F1 POU3F2 POU3F4	5.74e-06	16	144	4	PS51179
Domain	POU	POU1F1 POU3F1 POU3F2 POU3F4	7.46e-06	17	144	4	IPR013847
Domain	DEAH_ATP_HELICASE	SMARCA5 CHD8 RECQL4 SMARCA1 CHD6	1.04e-05	38	144	5	PS00690
Domain	CH	SYNE1 SPTBN2 SPTBN4 SYNE2 TAGLN3 DMD	1.07e-05	65	144	6	SM00033
Domain	CH	SYNE1 SPTBN2 SPTBN4 SYNE2 TAGLN3 DMD	1.65e-05	70	144	6	PF00307
Domain	-	SYNE1 SPTBN2 SPTBN4 SYNE2 TAGLN3 DMD	1.79e-05	71	144	6	1.10.418.10
Domain	CH	SYNE1 SPTBN2 SPTBN4 SYNE2 TAGLN3 DMD	2.11e-05	73	144	6	PS50021
Domain	CH-domain	SYNE1 SPTBN2 SPTBN4 SYNE2 TAGLN3 DMD	2.46e-05	75	144	6	IPR001715
Domain	-	POU1F1 POU3F1 POU3F2 POU3F4	5.18e-05	27	144	4	1.10.260.40
Domain	SLIDE	SMARCA5 SMARCA1	5.90e-05	2	144	2	IPR015195
Domain	ISWI_HAND-dom	SMARCA5 SMARCA1	5.90e-05	2	144	2	IPR015194
Domain	vATP-synt_AC39	ATP6V0D1 ATP6V0D2	5.90e-05	2	144	2	PF01992
Domain	ATPase_V0-cplx_dsu	ATP6V0D1 ATP6V0D2	5.90e-05	2	144	2	IPR016727
Domain	ATPase_V0-cplx_csu/dsu	ATP6V0D1 ATP6V0D2	5.90e-05	2	144	2	IPR002843
Domain	SLIDE	SMARCA5 SMARCA1	5.90e-05	2	144	2	PF09111
Domain	HAND	SMARCA5 SMARCA1	5.90e-05	2	144	2	PF09110
Domain	ISWI	SMARCA5 SMARCA1	5.90e-05	2	144	2	IPR029915
Domain	Lambda_DNA-bd_dom	POU1F1 POU3F1 POU3F2 POU3F4	6.93e-05	29	144	4	IPR010982
Domain	DNA/RNA_helicase_DEAH_CS	SMARCA5 CHD8 RECQL4 CHD6	1.47e-04	35	144	4	IPR002464
Domain	DUF4482	KIAA0408 MTCL1	1.76e-04	3	144	2	PF14818
Domain	DBINO	SMARCA5 SMARCA1	1.76e-04	3	144	2	IPR020838
Domain	DUF4482	KIAA0408 MTCL1	1.76e-04	3	144	2	IPR027882
Domain	DBINO	SMARCA5 SMARCA1	1.76e-04	3	144	2	PF13892
Domain	Helicase_C	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	1.80e-04	107	144	6	PF00271
Domain	HELICc	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	1.80e-04	107	144	6	SM00490
Domain	Helicase_C	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	1.90e-04	108	144	6	IPR001650
Domain	HELICASE_CTER	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	2.00e-04	109	144	6	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	2.00e-04	109	144	6	PS51192
Domain	DEXDc	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	2.00e-04	109	144	6	SM00487
Domain	Helicase_ATP-bd	SMARCA5 CHD8 BTAF1 RECQL4 SMARCA1 CHD6	2.10e-04	110	144	6	IPR014001
Domain	ARM-type_fold	RALGAPA1 ARFGEF2 TSC2 BTAF1 PPP6R1 CSE1L PIK3C2A MTOR AOPEP CLTC	3.04e-04	339	144	10	IPR016024
Domain	CTF_NFI	NFIA NFIX	3.51e-04	4	144	2	PF00859
Domain	CTF_NFI_1	NFIA NFIX	3.51e-04	4	144	2	PS00349
Domain	KASH	SYNE1 SYNE2	3.51e-04	4	144	2	IPR012315
Domain	CTF_NFI_2	NFIA NFIX	3.51e-04	4	144	2	PS51080
Domain	KASH	SYNE1 SYNE2	3.51e-04	4	144	2	PS51049
Domain	Spectrin_bsu	SPTBN2 SPTBN4	3.51e-04	4	144	2	IPR016343
Domain	CTF/NFI_DNA-bd-dom	NFIA NFIX	3.51e-04	4	144	2	IPR020604
Domain	KASH	SYNE1 SYNE2	3.51e-04	4	144	2	SM01249
Domain	NfI_DNAbd_pre-N	NFIA NFIX	3.51e-04	4	144	2	PF10524
Domain	KASH	SYNE1 SYNE2	3.51e-04	4	144	2	PF10541
Domain	CTF/NFI	NFIA NFIX	3.51e-04	4	144	2	IPR000647
Domain	CTF/NFI_DNA-bd_N	NFIA NFIX	3.51e-04	4	144	2	IPR019548
Domain	CTF/NFI_DNA-bd_CS	NFIA NFIX	3.51e-04	4	144	2	IPR019739
Domain	Ank	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	3.96e-04	228	144	8	PF00023
Domain	PRAME_family	PRAMEF5 PRAMEF27 PRAMEF6	3.97e-04	19	144	3	IPR026271
Domain	PAD	PADI4 PADI1	5.81e-04	5	144	2	PF03068
Domain	PAD_N	PADI4 PADI1	5.81e-04	5	144	2	PF08526
Domain	PAD_M	PADI4 PADI1	5.81e-04	5	144	2	PF08527
Domain	PAD	PADI4 PADI1	5.81e-04	5	144	2	IPR004303
Domain	PAD_C	PADI4 PADI1	5.81e-04	5	144	2	IPR013530
Domain	Prot_Arg_deaminase_cen_dom	PADI4 PADI1	5.81e-04	5	144	2	IPR013733
Domain	PAD_N	PADI4 PADI1	5.81e-04	5	144	2	IPR013732
Domain	-	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	6.89e-04	248	144	8	1.25.40.20
Domain	ANK	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	7.45e-04	251	144	8	SM00248
Domain	ANK_REPEAT	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	7.84e-04	253	144	8	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	8.04e-04	254	144	8	IPR020683
Domain	ANK_REP_REGION	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	8.04e-04	254	144	8	PS50297
Domain	BRK	CHD8 CHD6	8.68e-04	6	144	2	SM00592
Domain	BRK_domain	CHD8 CHD6	8.68e-04	6	144	2	IPR006576
Domain	BRK	CHD8 CHD6	8.68e-04	6	144	2	PF07533
Domain	Ankyrin_rpt	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	9.83e-04	262	144	8	IPR002110
Domain	Chromo	CHD8 CDY1 CHD6	1.02e-03	26	144	3	PF00385
Domain	CHROMO_1	CHD8 CDY1 CHD6	1.28e-03	28	144	3	PS00598
Domain	CHROMO_2	CHD8 CDY1 CHD6	1.28e-03	28	144	3	PS50013
Domain	Ank_2	ANKRD20A2P ANKRD20A3P ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	1.41e-03	215	144	7	PF12796
Domain	PH	ARHGEF28 PLEKHG7 SPTBN2 PLEKHG2 AFAP1L1 SPTBN4 RASAL2 ADAP2	1.43e-03	278	144	8	SM00233
Domain	PH_DOMAIN	ARHGEF28 PLEKHG7 SPTBN2 PLEKHG2 AFAP1L1 SPTBN4 RASAL2 ADAP2	1.47e-03	279	144	8	PS50003
Domain	PH_domain	ARHGEF28 PLEKHG7 SPTBN2 PLEKHG2 AFAP1L1 SPTBN4 RASAL2 ADAP2	1.50e-03	280	144	8	IPR001849
Domain	Chromodomain-like	CHD8 CDY1 CHD6	1.89e-03	32	144	3	IPR016197
Domain	PH_dom-spectrin-type	SPTBN2 SPTBN4	2.05e-03	9	144	2	IPR001605
Domain	Chromo/shadow_dom	CHD8 CDY1 CHD6	2.07e-03	33	144	3	IPR000953
Domain	CHROMO	CHD8 CDY1 CHD6	2.07e-03	33	144	3	SM00298
Domain	TPR-like_helical_dom	USP28 FANCG TTC23 MTOR TONSL CLTC CFAP70	2.23e-03	233	144	7	IPR011990
Domain	P-loop_NTPase	DNHD1 DNAH3 SMARCA5 ABCC5 CHD8 BTAF1 OPA1 STARD9 RECQL4 SMARCA1 MYH15 CHD6 GNAS KIF13A MYO16	2.33e-03	848	144	15	IPR027417
Domain	Rap_GAP	RALGAPA1 TSC2	2.55e-03	10	144	2	PF02145
Domain	Rap_GAP_dom	RALGAPA1 TSC2	3.10e-03	11	144	2	IPR000331
Domain	RAPGAP	RALGAPA1 TSC2	3.10e-03	11	144	2	PS50085
Domain	MAD_homology1_Dwarfin-type	NFIA NFIX	3.70e-03	12	144	2	IPR003619
Domain	DWA	NFIA NFIX	3.70e-03	12	144	2	SM00523
Domain	MH1	NFIA NFIX	3.70e-03	12	144	2	PF03165
Domain	C2	INPP4A UNC13D SYT15 PIK3C2A RASAL2	4.21e-03	137	144	5	SM00239
Domain	C2	INPP4A UNC13D SYT15 PIK3C2A RASAL2	4.90e-03	142	144	5	PS50004
Domain	Dynein_HC_stalk	DNHD1 DNAH3	5.06e-03	14	144	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH3	5.06e-03	14	144	2	IPR013602
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 STIM2 SRSF10 ARHGEF28 MAP3K20 TSC2 PLEKHG2 MAST2 SRRT PIK3C2A MTOR STARD9 SYNE2 FAM53B MPHOSPH9 MTCL1 GNAS KIF13A RGL2 RASAL2 EXOC4	3.84e-10	861	157	21	36931259
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	4.00e-10	4	157	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10 ERVK-5 ERVK-19	4.00e-10	4	157	4	7983737
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-5 ERVK-19 ERVK-24	4.74e-10	94	157	9	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19	1.36e-09	12	157	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-21 ERVK-19	1.99e-09	5	157	4	12629516
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	2.76e-08	8	157	4	12634303
Pubmed	Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway.	PNPLA2 TSC2 MTOR	3.60e-07	4	157	3	23858058
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F1 POU3F2 POU3F4	3.60e-07	4	157	3	1565620
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	3.60e-07	4	157	3	19091768
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7 ERVK-5	8.97e-07	5	157	3	11401426
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 AOPEP SYNE2	8.97e-07	5	157	3	22632968
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F1 POU3F2 POU3F4	8.97e-07	5	157	3	9105675
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	8.97e-07	5	157	3	17855024
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.16e-06	18	157	4	18664271
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU1F1 POU3F1 POU3F2	1.79e-06	6	157	3	2739723
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-9 ERVK-19	1.79e-06	6	157	3	15063128
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	1.83e-06	20	157	4	26694250
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	2.74e-06	22	157	4	31729367
Pubmed	POU homeodomain genes and myogenesis.	POU1F1 POU3F1 POU3F4	3.12e-06	7	157	3	8900043
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	STIM2 KDM5C PDCD7 DMXL1 SYNE2 GNAS	3.98e-06	92	157	6	15840729
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	4.70e-06	25	157	4	37451217
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F1 POU3F2 POU3F4	7.43e-06	9	157	3	15872005
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	7.52e-06	28	157	4	25089626
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	USP28 SYNE1 SPTBN2 WDR18 CHD8 TSC2 PPP6R1 OPA1 SPTBN4 MTOR SYNE2 TAGLN3 CLTC MTCL1 WNK2 RASAL2	8.18e-06	963	157	16	28671696
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ARHGEF28 POLRMT CHD8 BTAF1 PPP6R1 ECE1 INTS3 MAST2 SRRT RECQL4 TONSL RASAL2 EXOC4	8.76e-06	650	157	13	38777146
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-21 ERVK-19	1.06e-05	10	157	3	12970426
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 EXOSC10 SMARCA5 SYNE1 MAST2 CLTC DMD KIF13A	1.20e-05	234	157	8	36243803
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EXOSC10 SMARCA5 ARFGEF2 WDR18 CHD8 BTAF1 INTS3 CSE1L MTCL1 GNAS LAS1L EXOC4	1.45e-05	582	157	12	20467437
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	1.88e-05	35	157	4	19389355
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F1 POU3F2 POU3F4	1.93e-05	12	157	3	8276397
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RALGAPA1 STIM2 ARFGEF2 BCAT2 TSC2 SPG11 ECE1 DMXL1 SYNE2 WDR41 RASAL2	1.99e-05	504	157	11	34432599
Pubmed	Expression, purification and characterization of human vacuolar-type H(+)-ATPase subunit d1 and d2 in Escherichia coli.	ATP6V0D1 ATP6V0D2	2.02e-05	2	157	2	24631925
Pubmed	BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2.	POU3F2 POU3F4	2.02e-05	2	157	2	31371344
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	2.02e-05	2	157	2	11792814
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	2.02e-05	2	157	2	24931616
Pubmed	Loss of TSC2 confers resistance to ceramide and nutrient deprivation.	TSC2 MTOR	2.02e-05	2	157	2	23604129
Pubmed	Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes.	PNPLA2 MTOR	2.02e-05	2	157	2	25422441
Pubmed	Microglial ASD-related genes are involved in oligodendrocyte differentiation.	CHD8 TSC2	2.02e-05	2	157	2	34497307
Pubmed	Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes.	PNPLA2 MTOR	2.02e-05	2	157	2	19190264
Pubmed	mTORC2 is required for proliferation and survival of TSC2-null cells.	TSC2 MTOR	2.02e-05	2	157	2	21482669
Pubmed	Mannan and peptidoglycan induce COX-2 protein in human PMN via the mammalian target of rapamycin.	PTGS2 MTOR	2.02e-05	2	157	2	17683115
Pubmed	Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.	TSC2 MTOR	2.02e-05	2	157	2	23699409
Pubmed	TSC2 regulates VEGF through mTOR-dependent and -independent pathways.	TSC2 MTOR	2.02e-05	2	157	2	12957289
Pubmed	Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.	TSC2 MTOR	2.02e-05	2	157	2	24591652
Pubmed	mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.	TSC2 MTOR	2.02e-05	2	157	2	34667149
Pubmed	Cyclooxygenase-2 or tumor necrosis factor-α inhibitors attenuate the mechanotransductive effects of pulsed focused ultrasound to suppress mesenchymal stromal cell homing to healthy and dystrophic muscle.	PTGS2 DMD	2.02e-05	2	157	2	25534849
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	2.02e-05	2	157	2	22768332
Pubmed	Development of hypomelanotic macules is associated with constitutive activated mTORC1 in tuberous sclerosis complex.	TSC2 MTOR	2.02e-05	2	157	2	28336152
Pubmed	Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin.	TSC2 MTOR	2.02e-05	2	157	2	29364507
Pubmed	Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.	TSC2 MTOR	2.02e-05	2	157	2	22287548
Pubmed	Heterotrimeric G protein Gαs subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction.	PLEKHG2 GNAS	2.02e-05	2	157	2	28108261
Pubmed	Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.	TSC2 MTOR	2.02e-05	2	157	2	25972538
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.02e-05	2	157	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.02e-05	2	157	2	9460924
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	2.02e-05	2	157	2	17267447
Pubmed	A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2).	TSC2 MTOR	2.02e-05	2	157	2	22492229
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	2.02e-05	2	157	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	2.02e-05	2	157	2	24586179
Pubmed	Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins.	MTOR DMD	2.02e-05	2	157	2	23115080
Pubmed	Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.	TSC2 MTOR	2.02e-05	2	157	2	21886784
Pubmed	mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.	TSC2 MTOR	2.02e-05	2	157	2	27023784
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	2.02e-05	2	157	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	2.02e-05	2	157	2	31578382
Pubmed	Genome sequencing detects a balanced pericentric inversion with breakpoints that impact the DMD and upstream region of POU3F4 genes.	POU3F4 DMD	2.02e-05	2	157	2	37929330
Pubmed	Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity.	POU1F1 MTOR	2.02e-05	2	157	2	25720574
Pubmed	Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.	TSC2 MTOR	2.02e-05	2	157	2	24740570
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EXOSC10 POLA1 KDM5C CHD8 INTS3 SRRT CSE1L CLTC LAS1L	2.17e-05	332	157	9	32786267
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F1 POU3F2 POU3F4	2.50e-05	13	157	3	8543156
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F1 POU3F2 POU3F4	3.17e-05	14	157	3	17141158
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	3.17e-05	14	157	3	17662146
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SMARCA5 USP28 KDM5C POLRMT WDR18 BTAF1 PPP6R1 INTS3 NFIA NFIX RECQL4 SMARCA1 KDM1B ANKRD20A1	3.70e-05	857	157	14	25609649
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RALGAPA1 MAP3K20 TSC2 PPP6R1 MAST2 FAM193A PIK3C2A MPHOSPH9 MTCL1 RASAL2	3.81e-05	446	157	10	24255178
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	RALGAPA1 SYNE1 SPTBN2 OPA1 MTOR CLTC GNAS RASAL2	4.44e-05	281	157	8	28706196
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RALGAPA1 FAM184A EXOSC10 STIM2 SYNE1 SPTBN2 POLRMT SPG11 PPP6R1 DMXL1 FAM193A PIK3C2A SYNE2 CLTC WDR41 GNAS LAS1L RASAL2 EXOC4	4.45e-05	1487	157	19	33957083
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EXOSC10 SMARCA5 POLA1 SPTBN2 POLRMT WDR18 CHD8 CSE1L MTOR SYNE2 CLTC LAS1L	4.46e-05	653	157	12	22586326
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F1 POU3F2 POU3F4	4.84e-05	16	157	3	9118797
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF5 PRAMEF11 PRAMEF6	5.86e-05	17	157	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF5 PRAMEF11 PRAMEF6	5.86e-05	17	157	3	37781892
Pubmed	Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.	TSC2 MTOR	6.06e-05	3	157	2	17562867
Pubmed	Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration.	NFIX DMD	6.06e-05	3	157	2	29057908
Pubmed	Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.	TSC2 MTOR	6.06e-05	3	157	2	15624760
Pubmed	Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.	TSC2 MTOR	6.06e-05	3	157	2	17018601
Pubmed	Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.	POU3F2 POU3F4	6.06e-05	3	157	2	8703082
Pubmed	mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.	TSC2 MTOR	6.06e-05	3	157	2	29056426
Pubmed	Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma.	TSC2 MTOR	6.06e-05	3	157	2	26831717
Pubmed	Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous: Clinicopathologic and Molecular Study.	TSC2 MTOR	6.06e-05	3	157	2	32091432
Pubmed	Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.	POU1F1 MTOR	6.06e-05	3	157	2	25456069
Pubmed	Low-grade oncocytic tumor of kidney harboring TSC/MTOR mutation: clinicopathologic, immunohistochemical and molecular characteristics support a distinct entity.	TSC2 MTOR	6.06e-05	3	157	2	35099634
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	6.06e-05	3	157	2	9971820
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2	6.06e-05	3	157	2	16079285
Pubmed	Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.	NFIA NFIX	6.06e-05	3	157	2	31128945
Pubmed	Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.	TSC2 MTOR	6.06e-05	3	157	2	26735435
Pubmed	Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.	TSC2 MTOR	6.06e-05	3	157	2	23878397
Pubmed	Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.	TSC2 MTOR	6.06e-05	3	157	2	23592839
Pubmed	XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons.	TSC2 MTOR	6.06e-05	3	157	2	23348097
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	6.06e-05	3	157	2	28533432
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	TSC2 MTOR	6.06e-05	3	157	2	23966835
Pubmed	Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL3.	PLEKHG2 GNAS	6.06e-05	3	157	2	28489964
Pubmed	Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice.	TSC2 MTOR	6.06e-05	3	157	2	34032632
Interaction	GPR17 interactions	USP28 ARFGEF2 TSC2 SPG11 BTAF1 PPP6R1 INTS3 OPA1 FANCG CSE1L MTOR TONSL EXOC4	1.51e-07	283	146	13	int:GPR17
Interaction	YWHAG interactions	KIAA0408 RALGAPA1 STIM2 SRSF10 ARHGEF28 MAP3K20 TSC2 ZNF395 PLEKHG2 MAST2 AFAP1L1 CSE1L PIK3C2A MTOR STARD9 SYNE2 RECQL4 CLTC FAM53B MPHOSPH9 MTCL1 GNAS KIF13A RGL2 ZRANB1 RASAL2 EXOC4	2.79e-07	1248	146	27	int:YWHAG
Interaction	YWHAH interactions	RALGAPA1 STIM2 SRSF10 ARHGEF28 MAP3K20 TSC2 ZNF395 PLEKHG2 MAST2 CEP128 SRRT PIK3C2A MTOR STARD9 SYNE2 RECQL4 FAM53B MPHOSPH9 MTCL1 RGL2 ZRANB1 WNK2 RASAL2 EXOC4	1.26e-06	1102	146	24	int:YWHAH
Interaction	ANKRD20A4P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	7.33e-06	6	146	3	int:ANKRD20A4P
Interaction	POU3F4 interactions	POU3F1 POU3F2 POU3F4	7.33e-06	6	146	3	int:POU3F4
Interaction	SFN interactions	KIAA0408 RALGAPA1 SRSF10 ARHGEF28 MAP3K20 TSC2 MAST2 PIK3C2A NFIA MTOR RECQL4 CLTC FAM53B MPHOSPH9 KIF13A ZRANB1 RASAL2	1.13e-05	692	146	17	int:SFN
Interaction	ANKRD20A2P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	1.28e-05	7	146	3	int:ANKRD20A2P
Interaction	COMTD1 interactions	USP28 BTAF1 PPP6R1 ECE1 INTS3 CSE1L MTOR ZRANB1 EXOC4	1.56e-05	200	146	9	int:COMTD1
Interaction	LAMTOR1 interactions	SPTBN2 ARFGEF2 ABCC5 TSC2 SPG11 ECE1 OPA1 DMXL1 PIK3C2A CLTC ATP6V0D2 WDR41 GNAS DMD ZRANB1 RASAL2 EXOC4	1.95e-05	722	146	17	int:LAMTOR1
Interaction	YWHAB interactions	RALGAPA1 STIM2 SRSF10 ARHGEF28 MAP3K20 TSC2 ZNF395 MAST2 AFAP1L1 PIK3C2A MTOR STARD9 RECQL4 CLTC FAM53B MPHOSPH9 MTCL1 RGL2 ZRANB1 RASAL2	4.41e-05	1014	146	20	int:YWHAB
Interaction	NUP43 interactions	SRSF10 POLA1 KDM5C WDR18 CHD8 CSMD3 SRRT NFIA SYNE2 RECQL4 TONSL SMARCA1 CHD6 LAS1L ZRANB1	4.99e-05	625	146	15	int:NUP43
Interaction	ANKRD20A1 interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	5.89e-05	11	146	3	int:ANKRD20A1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PADI4 EXOSC10 SRSF10 PRAMEF5 C1orf167 ECE1 MTOR MTHFR PRAMEF27 PRAMEF11 PADI1 PRAMEF6	4.16e-06	681	156	12	chr1p36
GeneFamily	POU class homeoboxes and pseudogenes	POU1F1 POU3F1 POU3F2 POU3F4	5.39e-06	23	93	4	523
GeneFamily	PRAME family	PRAMEF5 PRAMEF27 PRAMEF11 PRAMEF6	6.44e-06	24	93	4	686
GeneFamily	Ankyrin repeat domain containing	ANKRD20A2P ANKRD20A3P ANKRD54 ANKRD20A4P TONSL TRPV3 MYO16 ANKRD20A1	3.51e-05	242	93	8	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG7 SPTBN2 PLEKHG2 AFAP1L1 SPTBN4 RASAL2 ADAP2	9.31e-05	206	93	7	682
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.56e-04	4	93	2	1252
GeneFamily	Peptidyl arginine deiminases	PADI4 PADI1	2.59e-04	5	93	2	677
GeneFamily	SUMO specific peptidases\|5FMC ribosome biogenesis complex	WDR18 LAS1L	3.87e-04	6	93	2	1301
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN2 SPTBN4	5.41e-04	7	93	2	1113
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	SMARCA5 SMARCA1 CHD6	2.56e-03	53	93	3	532
GeneFamily	V-type ATPases	ATP6V0D1 ATP6V0D2	6.17e-03	23	93	2	415
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM1B	6.71e-03	24	93	2	485
Coexpression	BENPORATH_ES_WITH_H3K27ME3	SFRP4 SYNE1 SLC26A4 POU3F1 POU3F2 POU3F4 ANKRD20A2P ANKRD20A3P ANKRD20A8P CSMD3 ADGRA2 RIMBP3 SPTBN4 NFIA NFIX RIMBP3C RIMBP3B TSLP ANKRD20A1 ADAP2	4.43e-06	1115	147	20	M10371
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN	BTAF1 INTS3 FAM193A PIK3C2A MPHOSPH9 DMD	7.97e-06	84	147	6	M13008
Coexpression	GSE12845_IGD_NEG_BLOOD_VS_PRE_GC_TONSIL_BCELL_DN	HTR3A POLA1 PPP6R1 CSE1L TTC23 CLTC GNAS RGL2	1.67e-05	198	147	8	M3195
Coexpression	BENPORATH_PRC2_TARGETS	SLC26A4 POU3F1 POU3F4 ANKRD20A2P ANKRD20A3P ANKRD20A8P CSMD3 RIMBP3 NFIX RIMBP3C RIMBP3B TSLP ANKRD20A1 ADAP2	1.86e-05	650	147	14	M8448
Coexpression	BENPORATH_SUZ12_TARGETS	SLC26A4 POU3F1 POU3F4 ANKRD20A2P ANKRD20A3P ANKRD20A8P CSMD3 ADGRA2 RIMBP3 EML5 NFIA NFIX RIMBP3C GNAS RIMBP3B TSLP ANKRD20A1 ADAP2	2.09e-05	1035	147	18	M9898
Coexpression	BENPORATH_EED_TARGETS	SFRP4 INPP4A SLC26A4 POU3F1 POU3F2 POU3F4 ANKRD20A2P ANKRD20A3P ANKRD20A8P CSMD3 RIMBP3 EML5 NFIX RIMBP3C RIMBP3B TSLP ANKRD20A1 ADAP2	2.83e-05	1059	147	18	M7617
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 FAM184A SYNE1 C1orf87 SYNE2 CFAP70 DMD	4.40e-06	197	148	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	POU3F1 ECE1 NFIA AOPEP SYNE2 CHD6 TSLP	4.55e-06	198	148	7	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX MTCL1 DMD	4.86e-06	200	148	7	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX MTCL1 DMD	4.86e-06	200	148	7	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	NIPSNAP3B C1orf167 DMXL1 SYT15 ANGPTL5 SLFNL1	9.13e-06	145	148	6	80684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	NIPSNAP3B C1orf167 DMXL1 SYT15 ANGPTL5 SLFNL1	9.13e-06	145	148	6	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	droplet-Spleen-nan-3m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 SYNE1 PTGS2 TTC23 RASAL2 RUFY4	2.25e-05	170	148	6	dbd6c9c7be824a1ff1b31af791064127cafbd194
ToppCell	ASK454-Endothelial-Lymphatic\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	DNAH3 SLC26A4 AFAP1L1 FAM193A TTC23 LAS1L	3.01e-05	179	148	6	fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	NPDC1 ANKRD20A3P ECE1 AFAP1L1 CCM2L MTCL1	3.96e-05	188	148	6	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	POLA1 MAST2 CEP128 CSE1L TONSL MPHOSPH9	4.20e-05	190	148	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1 ADAP2	4.45e-05	192	148	6	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	RALGAPA1 SMARCA5 PIK3C2A CLTC KDM1B POMK	4.58e-05	193	148	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	ABCC5 BCAT2 ECE1 NFIA SYNE2 WNK2	4.58e-05	193	148	6	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPDC1 AFAP1L1 SYT15 CCM2L PIK3C2A RASAL2	4.72e-05	194	148	6	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SFRP4 POU3F2 ECE1 NFIX GNAS DMD	4.72e-05	194	148	6	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ECE1 AFAP1L1 CCM2L PIK3C2A RASAL2	4.72e-05	194	148	6	ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ECE1 AFAP1L1 CCM2L PIK3C2A RASAL2	4.99e-05	196	148	6	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ECE1 AFAP1L1 CCM2L PIK3C2A RASAL2	4.99e-05	196	148	6	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ECE1 AFAP1L1 CCM2L PIK3C2A RASAL2	4.99e-05	196	148	6	473980c827443464d08a0be28c53e3536369b12a
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KIAA0408 SFRP4 PNMT MAP3K20 AOPEP MTCL1	5.28e-05	198	148	6	2d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	DNAH3 PLEKHG7 C1orf87 CCDC148 EML5 CFAP70	5.28e-05	198	148	6	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.43e-05	199	148	6	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Sigmoid-T_cell-Tcm\|T_cell / Region, Cell class and subclass	FAM184A NIPSNAP3B KRBOX1 MTOR WDR41 POMK	5.43e-05	199	148	6	acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.58e-05	200	148	6	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.58e-05	200	148	6	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.58e-05	200	148	6	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.58e-05	200	148	6	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIAA0408 SFRP4 SYNE1 MAP3K20 NFIX DMD	5.58e-05	200	148	6	08bf8c00eee6468215edb3611296bfc8784c4d56
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 KDM5C TSC2 CSMD3 PTGS2 SPTBN4 MTOR SYNE2	3.40e-07	148	131	8	C0279702
Disease	Colorectal Carcinoma	DNAH3 SFRP4 SYNE1 SPTBN2 ABCC5 CSMD3 PTGS2 FANCG CSE1L MTHFR GNAS DMD LAS1L RASAL2 EXOC4	5.69e-07	702	131	15	C0009402
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 KDM5C CSMD3 PTGS2 SPTBN4 MTOR SYNE2	1.75e-06	128	131	7	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 KDM5C CSMD3 PTGS2 SPTBN4 MTOR SYNE2	1.75e-06	128	131	7	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 KDM5C CSMD3 PTGS2 SPTBN4 MTOR SYNE2	1.75e-06	128	131	7	C1266044
Disease	Papillary Renal Cell Carcinoma	DNHD1 KDM5C CSMD3 PTGS2 SPTBN4 MTOR SYNE2	1.75e-06	128	131	7	C1306837
Disease	Renal Cell Carcinoma	DNHD1 KDM5C CSMD3 PTGS2 SPTBN4 MTOR SYNE2	1.75e-06	128	131	7	C0007134
Disease	cognitive function measurement	CXorf38 MAP3K20 FBXL17 ABCC5 IRAK1BP1 POU3F2 GCNT4 CSMD3 ADGRA2 FAP CSE1L FAM193A NFIA NFIX MYH15 ATP6V0D2 FHDC1 WNK2 EXOC4	1.94e-05	1434	131	19	EFO_0008354
Disease	midregional pro atrial natriuretic peptide measurement	C1orf167 MTHFR	1.96e-05	2	131	2	EFO_0008468
Disease	cognitive function measurement, self reported educational attainment	PLEKHG7 ARFGEF2 POU3F2 BTAF1 CSE1L FAM193A NFIX MYH15 EXOC4	3.11e-05	355	131	9	EFO_0004784, EFO_0008354
Disease	Intellectual Disability	RALGAPA1 INPP4A SYNE1 KDM5C CHD8 NFIA MTOR SCN1A GNAS LAS1L	3.25e-05	447	131	10	C3714756
Disease	Sclerocystic Ovaries	PNPLA2 SRSF10 SPTBN4 TONSL GNAS DMD	4.61e-05	144	131	6	C1136382
Disease	Polycystic Ovary Syndrome	PNPLA2 SRSF10 SPTBN4 TONSL GNAS DMD	4.61e-05	144	131	6	C0032460
Disease	Focal Cortical Dysplasia of Taylor, Type IIb	TSC2 MTOR	5.85e-05	3	131	2	C1846389
Disease	FOCAL CORTICAL DYSPLASIA OF TAYLOR	TSC2 MTOR	5.85e-05	3	131	2	C1846385
Disease	Focal Cortical Dysplasia of Taylor, Type IIa	TSC2 MTOR	5.85e-05	3	131	2	C1846386
Disease	Endocrine System Diseases	MTOR GNAS	5.85e-05	3	131	2	C0014130
Disease	Isolated focal cortical dysplasia type II	TSC2 MTOR	5.85e-05	3	131	2	cv:C1846385
Disease	FOCAL CORTICAL DYSPLASIA, TYPE II	TSC2 MTOR	5.85e-05	3	131	2	607341
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN2 SPTBN4	1.17e-04	4	131	2	DOID:0050882 (implicated_via_orthology)
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.17e-04	4	131	2	cv:CN293514
Disease	blood pressure	SYNE1 MYO16 EXOC4	1.24e-04	22	131	3	EFO_0004325
Disease	cortical thickness	SPTBN2 ARFGEF2 ECE1 MAST2 ADGRA2 AFAP1L1 NFIA MTHFR NFIX FAM53B MTCL1 KIF13A MYO16 WNK2 EXOC4	1.30e-04	1113	131	15	EFO_0004840
Disease	Autistic Disorder	HTR3A KDM5C CHD8 TSC2 CSMD3 PTGS2 MTHFR	1.72e-04	261	131	7	C0004352
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	1.94e-04	5	131	2	C1450051
Disease	leiomyosarcoma	PTGS2 DMD	1.94e-04	5	131	2	C0023269
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	1.94e-04	5	131	2	C0410190
Disease	Leiomyosarcoma, Epithelioid	PTGS2 DMD	1.94e-04	5	131	2	C0205815
Disease	Leiomyosarcoma, Myxoid	PTGS2 DMD	1.94e-04	5	131	2	C0205816
Disease	acute kidney failure (implicated_via_orthology)	ECE1 PTGS2 MTOR	2.31e-04	27	131	3	DOID:3021 (implicated_via_orthology)
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	2.90e-04	6	131	2	cv:C0410189
Disease	Congenital muscular dystrophy (disorder)	SYNE2 POMK	2.90e-04	6	131	2	C0699743
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	2.90e-04	6	131	2	C0410189
Disease	migraine with aura (is_implicated_in)	MTHFR TRPV3	2.90e-04	6	131	2	DOID:10024 (is_implicated_in)
Disease	Profound Mental Retardation	INPP4A KDM5C CHD8 SCN1A GNAS	3.99e-04	139	131	5	C0020796
Disease	Mental Retardation, Psychosocial	INPP4A KDM5C CHD8 SCN1A GNAS	3.99e-04	139	131	5	C0025363
Disease	Mental deficiency	INPP4A KDM5C CHD8 SCN1A GNAS	3.99e-04	139	131	5	C0917816
Disease	Precocious Puberty	PTGS2 GNAS	4.05e-04	7	131	2	C0034013
Disease	Cryptogenic sexual precocity	PTGS2 GNAS	4.05e-04	7	131	2	C0271527
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6	4.05e-04	7	131	2	DOID:0050834 (implicated_via_orthology)
Disease	Central Precocious Puberty	PTGS2 GNAS	4.05e-04	7	131	2	C0342543
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	4.05e-04	7	131	2	C0751337
Disease	Testotoxicosis	PTGS2 GNAS	5.38e-04	8	131	2	C1504412
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	POLA1 KDM5C	5.38e-04	8	131	2	C0796250
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5C CHD8 TSC2 SCN1A CHD6	6.00e-04	152	131	5	DOID:0060041 (implicated_via_orthology)
Disease	Thyroid carcinoma	TSC2 PTGS2 MTOR	9.91e-04	44	131	3	C0549473
Disease	Adrenal Gland Neoplasms	PTGS2 GNAS	1.05e-03	11	131	2	C0001624
Disease	Adrenal Cancer	PTGS2 GNAS	1.05e-03	11	131	2	C0750887
Disease	Rheumatoid Arthritis	PADI4 ABCC5 POU3F1 PTGS2 MTHFR	1.10e-03	174	131	5	C0003873
Disease	Endogenous depression	PTGS2 MTHFR GNAS	1.13e-03	46	131	3	C0011573
Disease	vital capacity	TBX15 SYNE1 SPTBN2 ARFGEF2 WDR18 UNC13D TRIM71 AFAP1L1 CSE1L NFIA MTCL1 WDR41 MYO16 ADAP2	1.22e-03	1236	131	14	EFO_0004312
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	1.25e-03	12	131	2	DOID:11726 (implicated_via_orthology)
Disease	Gastrointestinal Diseases	CHD8 MTHFR	1.25e-03	12	131	2	C0017178
Disease	Functional Gastrointestinal Disorders	CHD8 MTHFR	1.25e-03	12	131	2	C0559031
Disease	Cholera Infantum	CHD8 MTHFR	1.25e-03	12	131	2	C1565321
Disease	Mouth Diseases	PTGS2 FANCG	1.25e-03	12	131	2	C0026636
Disease	Condition, Preneoplastic	BCAT2 TSC2 PTGS2 AOPEP	1.49e-03	110	131	4	C0282313
Disease	Precancerous Conditions	BCAT2 TSC2 PTGS2 AOPEP	1.49e-03	110	131	4	C0032927
Disease	phoneme awareness	ARFGEF2 CSE1L	1.72e-03	14	131	2	EFO_0021812
Disease	pulmonary hypertension (implicated_via_orthology)	ECE1 PTGS2 MTOR	1.80e-03	54	131	3	DOID:6432 (implicated_via_orthology)
Disease	schizophrenia (biomarker_via_orthology)	KDM5C PTGS2	1.98e-03	15	131	2	DOID:5419 (biomarker_via_orthology)
Disease	Schizophrenia	SRSF10 HTR3A SPTBN2 PTGS2 OPA1 EML5 MTOR MTHFR ERVK-8 GNAS MYO16	1.98e-03	883	131	11	C0036341
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	PLEKHG7 ARFGEF2 FBXL17 POU3F2 FAM193A NFIX EXOC4	2.06e-03	398	131	7	EFO_0003756, EFO_0003888, EFO_0004337
Disease	central nervous system disease (implicated_via_orthology)	SMARCA5 SMARCA1	2.25e-03	16	131	2	DOID:331 (implicated_via_orthology)
Disease	age at menopause	FBXL17 ADGRA2 OPA1 MTHFR CHD6 ZRANB1	2.35e-03	302	131	6	EFO_0004704
Disease	partial epilepsy	SMARCA5 SCN1A	2.55e-03	17	131	2	EFO_0004263
Disease	QT interval	STIM2 ARHGEF28 PNMT MAST2 NFIA AOPEP KDM1B EXOC4	2.71e-03	534	131	8	EFO_0004682
Disease	portal hypertension (implicated_via_orthology)	PTGS2 MTOR	3.18e-03	19	131	2	DOID:10762 (implicated_via_orthology)
Disease	polycystic kidney disease (biomarker_via_orthology)	MTOR GNAS	3.18e-03	19	131	2	DOID:0080322 (biomarker_via_orthology)
Disease	Bladder Neoplasm	PTGS2 MTOR MTHFR CHD6	3.57e-03	140	131	4	C0005695
Disease	Malignant neoplasm of urinary bladder	PTGS2 MTOR MTHFR CHD6	3.66e-03	141	131	4	C0005684
Disease	chronic obstructive pulmonary disease	FAM184A ARHGEF28 MAP3K20 AFAP1L1 TTC23 MPHOSPH9 MTCL1 KIF13A TSLP	3.68e-03	688	131	9	EFO_0000341
Disease	mean corpuscular hemoglobin concentration	ARFGEF2 FBXL17 ABCC5 TSC2 PPP6R1 ECE1 DMXL1 SYT15 FANCG MTHFR MYO16 ADAP2	3.83e-03	1105	131	12	EFO_0004528
Disease	cardiovascular system disease (is_implicated_in)	PTGS2 MTHFR	3.89e-03	21	131	2	DOID:1287 (is_implicated_in)
Disease	status epilepticus (implicated_via_orthology)	PTGS2 MTOR	3.89e-03	21	131	2	DOID:1824 (implicated_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	ARHGEF28 ANKRD54 CCDC148 NFIA ATP6V0D2 WDR41 DMD	3.90e-03	447	131	7	EFO_0000694, MONDO_0100096
Disease	Manic Disorder	POU3F2 MTHFR STARD9	3.92e-03	71	131	3	C0024713
Disease	cholangiocarcinoma (is_implicated_in)	MTHFR GNAS	4.26e-03	22	131	2	DOID:4947 (is_implicated_in)
Disease	anxiety disorder (implicated_via_orthology)	TSC2 SCN1A	4.26e-03	22	131	2	DOID:2030 (implicated_via_orthology)
Disease	e-selectin measurement	FBXL17 NPDC1	4.26e-03	22	131	2	EFO_0004575
Disease	bipolar disorder	INPP4A SYNE1 SPTBN2 NFIA STARD9 NFIX WNK2 RASAL2	4.32e-03	577	131	8	MONDO_0004985
Disease	electroencephalogram measurement	DNAH3 DMD MYO16	4.41e-03	74	131	3	EFO_0004357

Protein segments in the cluster

Peptide	Gene	Start	Entry
KWNCVEERICHLQRE	ANKRD20A1	726	Q5TYW2
TWKQLRRCLQEDVER	FAM74A1	71	Q5RGS3
QLLRKCLQALWLREA	C1orf167	541	Q5SNV9
LWCQQKKRARQERET	C1orf167	631	Q5SNV9
EQANERECEVLRKIW	CDY1	506	Q9Y6F8
EWRCVIIDEAHRLKN	CHD8	941	Q9HCK8
WLCEELKERENREKN	CEP128	876	Q6ZU80
QELCADLKAKVRQWR	CCDC148	361	Q8NFR7
KWNCVEERICHLQRE	ANKRD20A8P	726	Q5CZ79
LWQQDAEPRDELRCK	ANKRD54	71	Q6NXT1
CARWELSEKRVNLEQ	ARSL	181	P51690
CTWVIIAEERNRIQI	CSMD3	91	Q7Z407
RCIWLQREIEDLTQQ	CXorf49;	486	A8MYA2
LLWLAQREDKACSRI	ADGRA2	501	Q96PE1
KWNCVEERICHLQRE	ANKRD20A4P	726	Q4UJ75
LVLERIAWLLCLREQ	HTR3A	346	P46098
RDSWEEIQQRLLTVC	ARFGEF2	1676	Q9Y6D5
CQEKLTRVEKEWRRF	CCDC96	316	Q2M329
EKDRAALCQLWRAII	ADCK5	391	Q3MIX3
QKRIDGIIDFQRLWC	ANGPTL5	196	Q86XS5
QDAEVRHRWCELIVK	AOPEP	741	Q8N6M6
EQLKVLGDRWANICR	DMD	531	P11532
DILLKWQRLTEEQCL	DMD	556	P11532
RWQDLKIRALDTCKA	DNHD1	3776	Q96M86
RCLLLTWRDNEELIL	CCM2L	116	Q9NUG4
VLKTLQCWEQVLLRR	DMXL1	2526	Q9Y485
RRVAEEWLECQKRID	FAM193A	126	P78312
WTENLRQECSKLREE	FAM184A	641	Q8NB25
CETWIDRFRKLENAL	C1orf87	471	Q8N0U7
QANDCLVLKEQWIRA	ADAP2	101	Q9NPF8
RKDLWKVSLRDCRNV	ANTKMT	131	Q9BQD7
RIDCLRQADKVWRLD	NFIA	116	Q12857
CIDWNRNVLKRELGL	PADI1	546	Q9ULC6
EEELVFQKRQLLRVW	RIMBP3B	1476	A6NNM3
EEELVFQKRQLLRVW	RIMBP3C	1476	A6NJZ7
KLQDTCRTQLVWLVR	INTS3	136	Q68E01
VRCDPEIQELRQWQK	IQCK	231	Q8N0W5
ELCLEQNNKTEVWER	UROS	71	P10746
VEWAVLKCRLEQLEE	MTCL1	1176	Q9Y4B5
WLNVDKSLECIIQRV	INPP4A	531	Q96PE3
NKNVDILWQAAEICR	INPP4A	871	Q96PE3
KWNCVEERICHLQRE	ANKRD20A2P	726	Q5SQ80
WLQERERECQSQEEL	ARHGEF28	1471	Q8N1W1
NWVEIRLDARKFVCE	ANO7	736	Q6IWH7
FVERCIDWNRELLKR	PADI4	541	Q9UM07
KLRELECWKQELQDE	FHDC1	411	Q9C0D6
DALAKWEECQRQLLL	PNPLA2	431	Q96AD5
CLWQVVEDTLELLNR	MTHFR	631	P42898
RIDCLRQADKVWRLD	NFIX	116	Q14938
RRQACLVAVENAWRK	IRAK1BP1	171	Q5VVH5
EERECELLWKVEKIR	TRIM71	376	Q2Q1W2
VALQELLDWRRKLCE	MYO16	1796	Q9Y6X6
NDRWRDLDRKCPLQI	FAM53B	46	Q14153
EQEIDRWRVKCVQEV	PDCD7	271	Q8N8D1
EHIQNCRKWDTEIRL	PIK3C2A	491	O00443
RAEVRKALANCKEWQ	NIPSNAP3B	96	Q9BS92
VEDWKITNQILVDRC	MPHOSPH9	481	Q99550
LQLEKEVVRVWFCNR	POU3F1	376	Q03052
KDNCRRAENVLRLWI	RASAL2	161	Q9UJF2
LCREVKLWRKININE	KIAA0408	46	Q6ZU52
WLREHNRVCDVLKQE	PTGS2	291	P35354
CRQLENSLRETWELE	LAS1L	186	Q9Y4W2
SCLDLWREKNDRLVR	FANCG	11	O15287
KQELKGLDIVRRDWC	POLA1	1071	P09884
QLEKEVVRVWFCNRR	POU3F4	316	P49335
RKLWQLVCKNEEELI	MTERF2	116	Q49AM1
WCRLQREIRLTQKAD	NPDC1	206	Q9NQX5
ELECNDVVLFWRIQR	OPA1	871	O60313
CRRLERLWQEELNEV	ABCC5	146	O15440
IEQVRAICLRAWEKI	ERVK-10	416	P87889
IEQVRAICLRAWEKI	ERVK-19	416	Q9YNA8
IEQVRAICLRAWEKI	ERVK-21	416	P62683
IEQVRAICLRAWEKI	ERVK-24	416	P63145
IEQVRAICLRAWGKI	ERVK-5	416	Q9HDB9
IEQVRAICLRAWEKI	ERVK-6	416	Q7LDI9
IEQVRAICLRAWEKI	ERVK-7	416	P63130
IEQVRAICLRAWEKI	ERVK-8	416	P62685
IEQVRAICLRAWEKI	ERVK-9	416	P63126
IEQVRAICLRAWEKI	HERVK_113	416	P62684
CKRDELRKLWIEGIE	EXOC4	106	Q96A65
LQVVWQRSRDICLKK	EXOSC10	466	Q01780
KWNCVEERICHLQRE	ANKRD20A3P	726	Q5VUR7
ECRKWRQLTKEIQLT	KDM1B	146	Q8NB78
QEWLEDLVIRLLCVF	BTAF1	336	O14981
RRVKCQALNKWEPEL	CR1	276	P17927
RRVKCQALNKWEPEL	CR1	726	P17927
RRVKCQALNKWEPEL	CR1	1176	P17927
CRKWEEKLIRIQDNL	DNAH3	1066	Q8TD57
IKCLAEKLEEQQRDW	GCNT4	421	Q9P109
WPKDRVIINRLDNIC	CHD6	2091	Q8TD26
QAECIKKRIIWDLES	CFAP70	271	Q5T0N1
NWIINDRCVEVIAKE	FBXL17	576	Q9UF56
AEWRCEIEATLERLK	MAP3K20	281	Q9NYL2
DTKWLTLEVCREFQR	MBNL3	11	Q9NUK0
KLQRQLSQDDCKLWR	MAST2	86	Q6P0Q8
IVSKIFRNRQCWEDR	KRBOX1	111	C9JBD0
QCQVCAEWKREILRH	CXorf38	76	Q8TB03
AVKLWDQELRRCRAF	EML5	1631	Q05BV3
QRCWAARTQVEKRLV	ECE1	56	P42892
QQEALKRGCEQVLWL	BCAT2	241	O15382
TLRDQWEKALCRALR	POLRMT	436	O00411
WEKALCRALRETKNR	POLRMT	441	O00411
ERLQGCQRIVEDWQK	MTOR	1621	P42345
TWKQLRGCLQEDVQR	FAM74A4	71	Q5TZK3
LNCVRERWSDALIKR	KIF13A	1091	Q9H1H9
LNEQRLVSWVNLICK	RUNDC1	546	Q96C34
IRLEECCEQWRALEK	MEIOC	756	A2RUB1
LLEKWIRVAEECRLL	RGL2	331	O15211
LKNETLVGDCRRVIW	SYT15	251	Q9BQS2
VFWERCNELQDIEKI	SMARCA1	901	P28370
KKENCIRSIVDQWIR	TCP11X2	321	Q5H9J9
NERVELLQRQWEELC	SYNE1	7751	Q8NF91
RQWEDLCLRVAIRKQ	SYNE2	5896	Q8WXH0
LENKLVDWIILQCAE	TAGLN3	26	Q9UI15
EEELVFQKRQLLRVW	RIMBP3	1476	Q9UFD9
LNLEKEVVRVWFCNR	POU1F1	251	P28069
RLQDWEDQVRCDIRQ	RECQL4	1131	O94761
QCEWLIKSKIQLEAR	MYH15	916	Q9Y2K3
WNCRREVLQQLETQK	RABGGTA	66	Q92696
RDERRKWIQCFNDVT	GNAS	871	Q5JWF2
EEIQVELQCADLWKR	TBX15	111	Q96SF7
VLELIQEKDRLWQRL	RUFY4	496	Q6ZNE9
CPRRWKLQVLDLQDV	PRAMEF27	96	A3QJZ7
ETVRLWDVQSKQCIR	WDR18	291	Q9BV38
WLSCEELRTEVRQLK	POMK	71	Q9H5K3
IKENQQCLLREETWL	STARD9	686	Q9P2P6
LQLEKEVVRVWFCNR	POU3F2	391	P20265
IEQVRAICLRAWEKI	ERVK-9	416	P63128
CLKLIERNETARWKN	SCN1A	1396	P35498
IQEWCRQRWLVELGK	SLFNL1	361	Q499Z3
KEICWNLQNIRLREC	SRRT	476	Q9BXP5
WAKQLTVIREDQLLC	AFAP1L1	236	Q8TED9
EELLQWFLQEEKREC	CLTC	1551	Q00610
KGECWQDKERQLRAR	PNMT	136	P11086
DERVCLQWLKRVQNV	FAP	301	Q12884
LDKLEELEKQIWLCR	SPG11	1791	Q96JI7
RRWKLQVLDLQDVCE	PRAMEF6	96	Q5VXH4
AENSRDRKILNCWLK	nan	376	Q6ZTK2
KRNWRIVEDEPNKIC	CSE1L	71	P55060
LCELWQNLAKIRDNL	RALGAPA1	1091	Q6GYQ0
LCQLRRELDDLEQWI	SPTBN2	1696	O15020
LDRKWICGRQIEIQF	SRSF10	71	O75494
CDIPRLWRQNKIDAV	SLC26A4	466	O43511
CLRERLFRWQQIEKI	STIM2	426	Q9P246
FIVLVNCIDWLKRRD	TAS2R9	26	Q9NYW1
NCIDWLKRRDISLID	TAS2R9	31	Q9NYW1
LWDKIAAQLRELQLC	TONSL	1326	Q96HA7
CLVEKWRDQLSKRSI	SFRP4	271	Q6FHJ7
RRWKLQVLDLQDVCE	PRAMEF5	96	Q5TYX0
VWLLEQKLQVCCRVE	ZNF395	106	Q9H8N7
QKLQVCCRVEEVWLA	ZNF395	111	Q9H8N7
LDCIQEVEVNCKWIL	PRAMEF11	206	O60813
VRKKLGEIRQCWAEL	SPTBN4	1381	Q9H254
KCLEQVSQLQGLWRR	TSLP	136	Q969D9
VKTCLQRWRSEIEQD	USP28	541	Q96RU2
QCRLVERILTSWEEN	PPP6R1	436	Q9UPN7
DDFRLCLRINEVKWT	TRPV3	726	Q8NET8
LKWCEQNEQCRRLHV	PLEKHG7	416	Q6ZR37
LQCGRIIKEEWIEIE	TTC23	171	Q5W5X9
QEEKRLWIHCLQRLF	PLEKHG2	396	Q9H7P9
VAWCELQDRKLTKLE	WNK2	221	Q9Y3S1
VFWERCNELQDIEKI	SMARCA5	886	O60264
VVLRLQDLRCREDQW	UNC13D	246	Q70J99
VRIWELREKQQLAAE	WDR41	346	Q9HAD4
EQQEKLLREWLDCCV	ZRANB1	641	Q9UGI0
RVLLQCLKQESDWKV	TSC2	691	P49815
VREVCVQDVKLENQW	ZNF311	181	Q5JNZ3
KEQEIRNIVWIAECI	ATP6V0D2	321	Q8N8Y2
LKEQECRNIVWIAEC	ATP6V0D1	321	P61421
LQRQVEQARWLDEVK	KDM5C	921	P41229